GCA_035809395.1 - 14 region(s)

Identified secondary metabolite regions using strictness 'relaxed'

gnlProkkaGABLIMEM_1 (original name was: gnl|Prokka|GABLIMEM_1)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1.1	other	315,977	357,395	bacilysin	Other	100%
Region 1.2	sactipeptide	360,377	381,988	subtilosin A	RiPP:Thiopeptide	100%
Region 1.3	CDPS	597,522	618,268	pulcherriminic acid	Other	100%
Region 1.4	NRP-metallophore,NRPS	942,893	994,670	bacillibactin	NRP	100%

gnlProkkaGABLIMEM_2 (original name was: gnl|Prokka|GABLIMEM_2)

Region	Type	From	To	Most similar known cluster		Similarity
Region 2.1	NRPS,betalactone	65,758	104,727	fengycin	NRP	86%

gnlProkkaGABLIMEM_3 (original name was: gnl|Prokka|GABLIMEM_3)

Region	Type	From	To	Most similar known cluster		Similarity
Region 3.1	NRPS	1	15,448	plipastatin	NRP	30%

gnlProkkaGABLIMEM_6 (original name was: gnl|Prokka|GABLIMEM_6)

Region	Type	From	To	Most similar known cluster		Similarity
Region 6.1	NRPS	193,784	219,037	surfactin	NRP:Lipopeptide	43%

gnlProkkaGABLIMEM_8 (original name was: gnl|Prokka|GABLIMEM_8)

Region	Type	From	To	Most similar known cluster		Similarity
Region 8.1	NRPS	175,881	204,379	surfactin	NRP:Lipopeptide	43%

gnlProkkaGABLIMEM_10 (original name was: gnl|Prokka|GABLIMEM_10)

Region	Type	From	To	Most similar known cluster		Similarity
Region 10.1	terpene	198,565	219,368
Region 10.2	transAT-PKS,PKS-like,T3PKS,NRPS	831,649	946,440	bacillaene	Polyketide+NRP	100%

gnlProkkaGABLIMEM_12 (original name was: gnl|Prokka|GABLIMEM_12)

Region	Type	From	To	Most similar known cluster		Similarity
Region 12.1	lanthipeptide-class-ii	1	14,096
Region 12.2	T3PKS	126,308	167,405	1-carbapen-2-em-3-carboxylic acid	Other	16%
Region 12.3	terpene	215,862	237,760

gnlProkkaGABLIMEM_17 (original name was: gnl|Prokka|GABLIMEM_17)

Region	Type	From	To	Most similar known cluster		Similarity
Region 17.1	NRPS	1	9,889	surfactin	NRP:Lipopeptide	8%

Compact view

gnlProkkaGABLIMEM_1 - Region 1 - other

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Location: 315,977 - 357,395 nt. (total: 41,419 nt) Show pHMM detection rules used

other: (LmbU or Neocarzinostat or bcpB or frbD or mitE or vlmB or prnB or CaiA or bacilysin or orf2_PTase)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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Gene overview

KnownClusterBlast

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Similar known gene clusters from MIBiG 3.1

gnlProkkaGABLIMEM_1 - Region 2 - sactipeptide

Download region GenBank file

Download region SVG

Location: 360,377 - 381,988 nt. (total: 21,612 nt) Show pHMM detection rules used

sactipeptide: (subtilosin or thuricin or TIGR04404 or Subtilosin_A or skfc)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

KnownClusterBlast

Sactipeptides

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Similar known gene clusters from MIBiG 3.1

Sactipeptide predictions

Sactipeptide(s) for ctg1_371

ctg1_371

Leader:

MKKAVIVENK

Core:

GCATCSIGAACLVDGPIPDFEIAGATGLFGLWG

antiSMASH-DB 4.0 matches for ctg1_371

100.0% NC_000964.3and 235 others:

NC_014479.1 Sactipeptides: BSUW23_RS18740_sactipeptideNC_014639.1 Sactipeptides: BATR1942_RS15950_sactipeptideNC_014976.1 Sactipeptides: BSN5_RS09700_sactipeptideNC_016047.1 Sactipeptides: GYO_RS41165_sactipeptideNC_017195.1 Sactipeptides: I33_RS18040_sactipeptideNC_017743.1 Sactipeptides: MY9_RS18920_sactipeptideNC_019896.1 Sactipeptides: A7A1_RS01935_sactipeptideNC_020244.1 Sactipeptides: C663_RS18295_sactipeptideNZ_BDDH01000003.1 Sactipeptides: A7P71_RS10610_sactipeptideNZ_CABIVP010000002.1 Sactipeptides: FY199_RS09010_sactipeptideNZ_CP007409.1 Sactipeptides: Q433_RS18950_sactipeptideNZ_CP009796.1 Sactipeptides: OB04_RS19085_sactipeptideNZ_CP011101.1 Sactipeptides: bslm_RS18365_sactipeptideNZ_CP011534.1 Sactipeptides: ABA10_RS18725_sactipeptideNZ_CP011802.1 Sactipeptides: D068_RS17505_sactipeptideNZ_CP016767.1 Sactipeptides: BCV50_RS14935_sactipeptideNZ_CP017072.1 Sactipeptides: BGM23_RS02945_sactipeptideNZ_CP017112.1 Sactipeptides: BS16045_RS19810_sactipeptideNZ_CP017313.1 Sactipeptides: BH660_RS14630_sactipeptideNZ_CP017314.1 Sactipeptides: BSBS38_RS19215_sactipeptideNZ_CP017676.1 Sactipeptides: BKN48_RS08085_sactipeptideNZ_CP018173.1 Sactipeptides: BAX60_RS03615_sactipeptideNZ_CP020367.1 Sactipeptides: BSK2_RS19060_sactipeptideNZ_CP020722.1 Sactipeptides: B7470_RS09560_sactipeptideNZ_CP020915.1 Sactipeptides: B9L64_RS11255_sactipeptideNZ_CP021169.1 Sactipeptides: B9N48_RS18685_sactipeptideNZ_CP021498.1 Sactipeptides: S101444_RS19170_sactipeptideNZ_CP021892.1 Sactipeptides: S100333_RS19720_sactipeptideNZ_CP021903.1 Sactipeptides: CD007_RS18975_sactipeptideNZ_CP021911.1 Sactipeptides: CDO84_RS18225_sactipeptideNZ_CP021921.1 Sactipeptides: S101392_RS19440_sactipeptideNZ_CP022391.1 Sactipeptides: CFK25_RS18875_sactipeptideNZ_CP022890.1 Sactipeptides: CJZ70_RS01210_sactipeptideNZ_CP023257.1 Sactipeptides: CLD04_RS19470_sactipeptideNZ_CP023409.1 Sactipeptides: Bateq7PJ16_RS20450_sactipeptideNZ_CP025941.1 Sactipeptides: C0W65_RS07300_sactipeptideNZ_CP026010.1 Sactipeptides: BS11774_RS03710_sactipeptideNZ_CP026030.1 Sactipeptides: C2H91_RS12110_sactipeptideNZ_CP026035.1 Sactipeptides: C2H96_RS13375_sactipeptideNZ_CP026036.1 Sactipeptides: C2H93_RS16885_sactipeptideNZ_CP026521.1 Sactipeptides: C1T29_RS22385_sactipeptideNZ_CP028201.1 Sactipeptides: C7M16_RS17535_sactipeptideNZ_CP028202.1 Sactipeptides: C7M17_RS17600_sactipeptideNZ_CP028217.1 Sactipeptides: C7M29_RS06900_sactipeptideNZ_CP028218.1 Sactipeptides: C7M30_RS12605_sactipeptideNZ_CP028812.1 Sactipeptides: DAE22_RS20770_sactipeptideNZ_CP029364.1 Sactipeptides: DIC78_RS12275_sactipeptideNZ_CP029461.1 Sactipeptides: DJ572_RS18795_sactipeptideNZ_CP029465.1 Sactipeptides: DKG76_RS19825_sactipeptideNZ_CP029609.1 Sactipeptides: DL538_RS20030_sactipeptideNZ_CP031675.1 Sactipeptides: DYS67_RS19275_sactipeptideNZ_CP031783.1 Sactipeptides: D0808_RS00710_sactipeptideNZ_CP031784.1 Sactipeptides: D0819_RS14700_sactipeptideNZ_CP032853.1 Sactipeptides: D9C10_RS17955_sactipeptideNZ_CP032855.1 Sactipeptides: D9C11_RS09165_sactipeptideNZ_CP035161.1 Sactipeptides: EQH88_RS19675_sactipeptideNZ_CP035167.1 Sactipeptides: EQJ08_RS19095_sactipeptideNZ_CP035226.1 Sactipeptides: EQW70_RS20085_sactipeptideNZ_CP035231.1 Sactipeptides: EQZ01_RS19685_sactipeptideNZ_CP035391.1 Sactipeptides: ES965_RS19370_sactipeptideNZ_CP035395.1 Sactipeptides: ES968_RS19740_sactipeptideNZ_CP035401.1 Sactipeptides: ETA19_RS19595_sactipeptideNZ_CP035402.1 Sactipeptides: ES969_RS19660_sactipeptideNZ_CP035403.1 Sactipeptides: ETA15_RS19805_sactipeptideNZ_CP035406.1 Sactipeptides: ETK61_RS20735_sactipeptideNZ_CP035413.1 Sactipeptides: ETL58_RS19505_sactipeptideNZ_CP039935.1 Sactipeptides: FCJ76_RS19255_sactipeptideNZ_CP045006.1 Sactipeptides: F9B13_RS01950_sactipeptideNZ_CP045425.1 Sactipeptides: GCU76_RS20710_sactipeptideNZ_CP045816.1 Sactipeptides: GII86_RS19920_sactipeptideNZ_CP045824.1 Sactipeptides: GII78_RS20125_sactipeptideNZ_CP046591.1 Sactipeptides: GO004_RS15965_sactipeptideNZ_CP046860.1 Sactipeptides: GPJ55_RS11605_sactipeptideNZ_CP047645.1 Sactipeptides: GSN02_RS19265_sactipeptideNZ_CP049924.1 Sactipeptides: G4G26_RS18960_sactipeptideNZ_CP050705.1 Sactipeptides: HCU65_RS18920_sactipeptideNZ_CP051462.1 Sactipeptides: HC662_RS19240_sactipeptideNZ_CP051464.1 Sactipeptides: HC660_RS18970_sactipeptideNZ_CP054050.1 Sactipeptides: HNV25_RS02005_sactipeptideNZ_CP054177.1 Sactipeptides: HR084_RS18935_sactipeptideNZ_CP054584.1 Sactipeptides: HT135_RS19775_sactipeptideNZ_CP060193.1 Sactipeptides: H7F27_RS02180_sactipeptideNZ_CP060417.1 Sactipeptides: H8S71_RS18495_sactipeptideNZ_CP061284.1 Sactipeptides: ICJ61_RS19715_sactipeptideNZ_CP061870.1 Sactipeptides: IE382_RS22305_sactipeptideNZ_CP062497.1 Sactipeptides: IHV08_RS19770_sactipeptideNZ_CP063276.1 Sactipeptides: IM743_RS18070_sactipeptideNZ_CP065858.1 Sactipeptides: I7X10_RS03370_sactipeptideNZ_CP069789.1 Sactipeptides: JR441_RS19085_sactipeptideNZ_CP070483.1 Sactipeptides: JQX68_RS19175_sactipeptideNZ_CP070976.1 Sactipeptides: JYG31_RS19675_sactipeptideNZ_CP071043.1 Sactipeptides: JS609_RS19245_sactipeptideNZ_CP073265.1 Sactipeptides: KCX77_RS18900_sactipeptideNZ_CP075344.1 Sactipeptides: KIL00_RS20100_sactipeptideNZ_CP076083.1 Sactipeptides: KFF76_RS18635_sactipeptideNZ_CP079759.1 Sactipeptides: KXZ66_RS19695_sactipeptideNZ_CP080508.1 Sactipeptides: K0V03_RS08595_sactipeptideNZ_CP089148.1 Sactipeptides: LRO88_RS20980_sactipeptideNZ_CP090125.1 Sactipeptides: LXE94_RS19505_sactipeptideNZ_CP093289.1 Sactipeptides: MNG38_RS19730_sactipeptideNZ_CP093546.1 Sactipeptides: MOW04_RS19180_sactipeptideNZ_CP095736.1 Sactipeptides: MX663_RS20090_sactipeptideNZ_CP096590.1 Sactipeptides: M0696_RS18995_sactipeptideNZ_CP096889.1 Sactipeptides: EFK13_RS19225_sactipeptideNZ_CP098738.1 Sactipeptides: NDR85_RS18965_sactipeptideNZ_CP100651.1 Sactipeptides: NLW79_RS19990_sactipeptideNZ_CP100752.1 Sactipeptides: NLV76_RS19060_sactipeptideNZ_CP101718.1 Sactipeptides: NPA28_RS19075_sactipeptideNZ_CP101936.1 Sactipeptides: NP434_RS18980_sactipeptideNZ_CP103352.1 Sactipeptides: NX823_RS19780_sactipeptideNZ_CP104878.1 Sactipeptides: N8A75_RS20105_sactipeptideNZ_CP107539.1 Sactipeptides: OEG95_RS19105_sactipeptideNZ_CP110264.1 Sactipeptides: OMK57_RS18975_sactipeptideNZ_CP114899.1 Sactipeptides: O6U12_RS19480_sactipeptideNZ_CP116773.1 Sactipeptides: PNF29_RS01990_sactipeptideNZ_FTMW01000001.1 Sactipeptides: BW968_RS02045_sactipeptideNZ_JAAUXF010000005.1 Sactipeptides: HC742_RS19325_sactipeptideNZ_JABRUZ010000003.1 Sactipeptides: HRF55_RS03085_sactipeptideNZ_JABRVH010000018.1 Sactipeptides: HRF53_RS09100_sactipeptideNZ_JABUKD010000002.1 Sactipeptides: HRW04_RS09345_sactipeptideNZ_JAEACL010000001.1 Sactipeptides: I5F14_RS00800_sactipeptideNZ_JAHVOC010000002.1 Sactipeptides: KXD37_RS07830_sactipeptideNZ_JAJFDG010000003.1 Sactipeptides: LJF29_RS11575_sactipeptideNZ_JAJHUI010000011.1 Sactipeptides: LK399_RS16325_sactipeptideNZ_JALAJC010000012.1 Sactipeptides: MOB18_RS16080_sactipeptideNZ_JALAKW010000005.1 Sactipeptides: MOB93_RS12665_sactipeptideNZ_JALAKZ010000001.1 Sactipeptides: MOB76_RS02240_sactipeptideNZ_JALALA010000011.1 Sactipeptides: MOB82_RS15020_sactipeptideNZ_JALALE010000020.1 Sactipeptides: MOB33_RS20855_sactipeptideNZ_JALALO010000006.1 Sactipeptides: MOB75_RS09230_sactipeptideNZ_JALAMD010000002.1 Sactipeptides: MOB22_RS02315_sactipeptideNZ_JALAME010000005.1 Sactipeptides: MOC02_RS13805_sactipeptideNZ_JALAMJ010000012.1 Sactipeptides: MOB80_RS16635_sactipeptideNZ_JALAMO010000007.1 Sactipeptides: MOB98_RS08535_sactipeptideNZ_JALAMR010000019.1 Sactipeptides: MOC09_RS17975_sactipeptideNZ_JALAMZ010000002.1 Sactipeptides: MOC43_RS01370_sactipeptideNZ_JALANN010000012.1 Sactipeptides: MOC49_RS18290_sactipeptideNZ_JALANX010000001.1 Sactipeptides: MOC25_RS03365_sactipeptideNZ_JALAPT010000001.1 Sactipeptides: MOC95_RS01580_sactipeptideNZ_JALAPV010000005.1 Sactipeptides: MOC91_RS13515_sactipeptideNZ_JALAPW010000003.1 Sactipeptides: MOD18_RS06235_sactipeptideNZ_JALAPX010000003.1 Sactipeptides: MOC97_RS06805_sactipeptideNZ_JALAPZ010000002.1 Sactipeptides: MOC81_RS03830_sactipeptideNZ_JALAQA010000008.1 Sactipeptides: MOD07_RS14955_sactipeptideNZ_JALAQC010000001.1 Sactipeptides: MOD00_RS01290_sactipeptideNZ_JALAQD010000002.1 Sactipeptides: MOD08_RS05770_sactipeptideNZ_JALAQE010000002.1 Sactipeptides: MOD19_RS04725_sactipeptideNZ_JALASB010000002.1 Sactipeptides: MOD42_RS03685_sactipeptideNZ_JALASC010000024.1 Sactipeptides: MOD69_RS20580_sactipeptideNZ_JALASM010000006.1 Sactipeptides: MOD51_RS10970_sactipeptideNZ_JALASR010000006.1 Sactipeptides: MOD87_RS10780_sactipeptideNZ_JALAST010000011.1 Sactipeptides: MOE17_RS14670_sactipeptideNZ_JALASW010000005.1 Sactipeptides: MOE15_RS06925_sactipeptideNZ_JALATC010000001.1 Sactipeptides: MOD56_RS03380_sactipeptideNZ_JALATD010000001.1 Sactipeptides: MOE02_RS03350_sactipeptideNZ_JALATE010000006.1 Sactipeptides: MOD98_RS11440_sactipeptideNZ_JALATF010000003.1 Sactipeptides: MOD44_RS09960_sactipeptideNZ_JALATG010000002.1 Sactipeptides: MOE16_RS03490_sactipeptideNZ_JALATJ010000007.1 Sactipeptides: MOD90_RS15770_sactipeptideNZ_JALATU010000001.1 Sactipeptides: MOE27_RS01985_sactipeptideNZ_JALATV010000005.1 Sactipeptides: MOD97_RS07020_sactipeptideNZ_JALAUA010000008.1 Sactipeptides: MOD32_RS16030_sactipeptideNZ_JALAUD010000001.1 Sactipeptides: MOE28_RS03345_sactipeptideNZ_JALAUJ010000006.1 Sactipeptides: MOE37_RS12685_sactipeptideNZ_JALAUK010000012.1 Sactipeptides: MOE38_RS11825_sactipeptideNZ_JALAUV010000003.1 Sactipeptides: MOE71_RS06545_sactipeptideNZ_JALAUW010000015.1 Sactipeptides: MOE83_RS13210_sactipeptideNZ_JALAVA010000002.1 Sactipeptides: MOE81_RS02625_sactipeptideNZ_JALAVE010000001.1 Sactipeptides: MOE67_RS03645_sactipeptideNZ_JALAVI010000011.1 Sactipeptides: MOE80_RS14660_sactipeptideNZ_JALAVK010000006.1 Sactipeptides: MOE96_RS10120_sactipeptideNZ_JALAVL010000002.1 Sactipeptides: MOE60_RS03290_sactipeptideNZ_JALAVM010000009.1 Sactipeptides: MOE49_RS16195_sactipeptideNZ_JALAVO010000008.1 Sactipeptides: MOE63_RS14665_sactipeptideNZ_JALAVQ010000003.1 Sactipeptides: MOE59_RS02420_sactipeptideNZ_JALAVS010000002.1 Sactipeptides: MOE46_RS02250_sactipeptideNZ_JALAVT010000005.1 Sactipeptides: MOF25_RS08325_sactipeptideNZ_JALAVU010000004.1 Sactipeptides: MOE78_RS09660_sactipeptideNZ_JALAVV010000004.1 Sactipeptides: MOE66_RS02855_sactipeptideNZ_JALAVW010000001.1 Sactipeptides: MOE86_RS01005_sactipeptideNZ_JALAVX010000009.1 Sactipeptides: MOE40_RS07525_sactipeptideNZ_JALAVZ010000002.1 Sactipeptides: MOF00_RS02525_sactipeptideNZ_JALAWB010000008.1 Sactipeptides: MOE87_RS15020_sactipeptideNZ_JALAWK010000002.1 Sactipeptides: MOF06_RS12140_sactipeptideNZ_JALAWW010000010.1 Sactipeptides: MOF23_RS17300_sactipeptideNZ_JALAXQ010000012.1 Sactipeptides: MOF24_RS14120_sactipeptideNZ_JALAXV010000001.1 Sactipeptides: MOF15_RS00375_sactipeptideNZ_JALAYA010000016.1 Sactipeptides: MOF34_RS08915_sactipeptideNZ_JALAYD010000019.1 Sactipeptides: MOF39_RS20725_sactipeptideNZ_JALNTO010000006.1 Sactipeptides: MTN95_RS11045_sactipeptideNZ_JAMDFN010000008.1 Sactipeptides: M3M31_RS18245_sactipeptideNZ_JAMYDW010000003.1 Sactipeptides: NHM07_RS10830_sactipeptideNZ_JANBMP010000002.1 Sactipeptides: NL430_RS07940_sactipeptideNZ_JANDGG010000001.1 Sactipeptides: NKU38_RS03365_sactipeptideNZ_JANFAP010000001.1 Sactipeptides: NEC81_RS02065_sactipeptideNZ_JAQFFE010000015.1 Sactipeptides: PG051_RS13540_sactipeptideNZ_JAQOXM010000001.1 Sactipeptides: PO770_RS01950_sactipeptideNZ_JH600279.1 Sactipeptides: GYU_RS0104160_sactipeptideNZ_JXHL01000020.1 Sactipeptides: B4069_RS07025_sactipeptideNZ_JXHP01000031.1 Sactipeptides: B4073_RS09425_sactipeptideNZ_JXHR01000010.1 Sactipeptides: B4146_RS06925_sactipeptideNZ_KZ848487.1 Sactipeptides: DSL71_RS14015_sactipeptideNZ_LPVE01000021.1 Sactipeptides: AU385_RS06600_sactipeptideNZ_LSBB01000001.1 Sactipeptides: AXI57_RS01770_sactipeptideNZ_LUUT01000004.1 Sactipeptides: A6751_RS18460_sactipeptideNZ_MOEO01000004.1 Sactipeptides: BLL41_RS09830_sactipeptideNZ_MUXL01000002.1 Sactipeptides: B0W20_RS08845_sactipeptideNZ_MZZI01000001.1 Sactipeptides: B2G85_RS18515_sactipeptideNZ_NBBO01000003.1 Sactipeptides: B6K89_RS01830_sactipeptideNZ_NERK01000024.1 Sactipeptides: B9T64_RS18540_sactipeptideNZ_NJRD01000003.1 Sactipeptides: CE053_RS09115_sactipeptideNZ_NJRE01000002.1 Sactipeptides: CE047_RS07205_sactipeptideNZ_NKAK01000003.1 Sactipeptides: CE489_RS10400_sactipeptideNZ_NMOM01000004.1 Sactipeptides: CFI07_RS07245_sactipeptideNZ_PHIE01000002.1 Sactipeptides: CVV77_RS10760_sactipeptideNZ_PJCT01000002.1 Sactipeptides: CW370_RS11825_sactipeptideNZ_PVQM01000002.1 Sactipeptides: C6W22_RS11490_sactipeptideNZ_PVQN01000002.1 Sactipeptides: C6W23_RS05885_sactipeptideNZ_PVRK01000001.1 Sactipeptides: C6350_RS02025_sactipeptideNZ_PVWC01000004.1 Sactipeptides: C6372_RS11675_sactipeptideNZ_QRFZ01000012.1 Sactipeptides: DXT72_RS19010_sactipeptideNZ_SDKE01000003.1 Sactipeptides: EUA35_RS12130_sactipeptideNZ_SHOB01000002.1 Sactipeptides: ES060_RS14270_sactipeptideNZ_SIRN01000006.1 Sactipeptides: EYH65_RS15720_sactipeptideNZ_SNWK01000001.1 Sactipeptides: DFO69_RS02055_sactipeptideNZ_SOBO01000012.1 Sactipeptides: DFO78_RS18210_sactipeptideNZ_SORJ01000001.1 Sactipeptides: BJ795_RS03350_sactipeptideNZ_VBRP01000025.1 Sactipeptides: FE220_RS07065_sactipeptideNZ_VFNF01000001.1 Sactipeptides: FB592_RS03405_sactipeptideNZ_VIOH01000001.1 Sactipeptides: FLN47_RS01935_sactipeptideNZ_VLJK01000012.1 Sactipeptides: L605_RS10195_sactipeptideNZ_VLJL01000006.1 Sactipeptides: L604_RS05585_sactipeptideNZ_VLJX01000001.1 Sactipeptides: L609_RS01950_sactipeptideNZ_VTEK01000003.1 Sactipeptides: FZC71_RS10310_sactipeptideNZ_WTKJ01000004.1 Sactipeptides: NWT17_RS06185_sactipeptide

Sactipeptides: BSU_37350_sactipeptide

1

GCATCSIGAACLVDGPIPDFEIAGATGLFGLWG

33

GCATCSIGAACLVDGPIPDFEIAGATGLFGLWG

1

GCATCSIGAACLVDGPIPDFEIAGATGLFGLWG

33

97.0% NZ_CP092751.1: Sactipeptides: MKF32_RS18515_sactipeptide

1

GCATCSIGAACLVDGPIPDFEIAGATGLFGLWG

33

GCATCSIGA CLVDGPIPDFEIAGATGLFGLWG

1

GCATCSIGAVCLVDGPIPDFEIAGATGLFGLWG

33

93.9% NZ_CP048852.1: Sactipeptides: G4P54_RS19300_sactipeptide

1

GCATCSIGAACLVDGPIPDFEIAGATGLFGLWG

33

GCATCSIGA CLVDGPIPDFE+AGATGLFGLWG

1

GCATCSIGAVCLVDGPIPDFEVAGATGLFGLWG

33

with 15 more sequence matches

90.9% NZ_JALAKO010000018.1and 1 other:

NZ_JALAOG010000035.1 Sactipeptides: MOC96_RS18415_sactipeptide

Sactipeptides: MOB26_RS11095_sactipeptide

1

GCATCSIGAACLVDGPIPDFEIAGATGLFGLWG

33

GCATCSIGA CLVDGPIPDFEI G TGLFGLWG

1

GCATCSIGAVCLVDGPIPDFEIGGVTGLFGLWG

33

87.9% NZ_CP026362.1and 3 others:

NZ_CP033052.1 Sactipeptides: D9779_RS19215_sactipeptideNZ_JALAPG010000031.1 Sactipeptides: MOC70_RS13155_sactipeptideNZ_JALAQI010000016.1 Sactipeptides: MOD13_RS11485_sactipeptide

Sactipeptides: BV11031_RS20865_sactipeptide

1

GCATCSIGAACLVDGPIPDFEIAGATGLFGLWG

33

GCATCSIGA CLVDG IPDFEI G TGLFGLWG

1

GCATCSIGAVCLVDGFIPDFEIGGVTGLFGLWG

33

78.8% NZ_NXEM01000021.1: Sactipeptides: CPT06_RS05595_sactipeptide

1

GCATCSIGAACLVDGPIPDFEIAGATGLFGLWG

33

GC TCSIGA CLV+GPIPDF+ G TGLFGLWG

1

GCTTCSIGAVCLVNGPIPDFKTGGVTGLFGLWG

33

72.7% NC_014925.1and 17 others:

NZ_ANOI01000001.1 Sactipeptides: F779_RS13290_sactipeptideNZ_CP031604.1 Sactipeptides: DNJ55_RS07055_sactipeptideNZ_CP031605.1 Sactipeptides: DRC71_RS00165_sactipeptideNZ_CP035741.1 Sactipeptides: EW136_RS01865_sactipeptideNZ_CP039747.1 Sactipeptides: EFT29_RS00935_sactipeptideNZ_CP054206.2 Sactipeptides: HP560_RS11995_sactipeptideNZ_CP060700.1 Sactipeptides: H9Q12_RS10940_sactipeptideNZ_CP065920.1 Sactipeptides: JC281_RS11580_sactipeptideNZ_CP076465.1 Sactipeptides: KDE16_RS00560_sactipeptideNZ_JANPRJ010000013.1 Sactipeptides: NVR03_RS10250_sactipeptideNZ_JANPRN010000039.1 Sactipeptides: NVR04_RS07875_sactipeptideNZ_JTKO01000012.1 Sactipeptides: NO87_RS10650_sactipeptideNZ_LR134267.1 Sactipeptides: EL085_RS11430_sactipeptideNZ_MQMO01000006.1 Sactipeptides: BSR38_RS07375_sactipeptideNZ_MQNF01000024.1 Sactipeptides: BSR36_RS12515_sactipeptideNZ_QQPJ01000025.1 Sactipeptides: DV949_RS11300_sactipeptideNZ_SEZW01000001.1 Sactipeptides: EWV33_RS08610_sactipeptide

Sactipeptides: SPSINT_RS00615_sactipeptide

1

GCATCSIGAACLVDGPIPDFEIAGATGLFGL

31

GC+TCSIGAACL+DGP+PDFE+ G TG+FGL

1

GCSTCSIGAACLIDGPLPDFEVMGITGIFGL

31

69.7% NZ_CP027770.1: Sactipeptides: C7J90_RS04260_sactipeptide

1

GCATCSIGAACLVDGPIPDFEIAGATGLFGL

31

GC+ CSIGAACL+DGP PDFE+ G TG FGL

1

GCSACSIGAACLIDGPFPDFEVMGITGTFGL

31

69.7% NZ_CP066885.1: Sactipeptides: JGZ27_RS11325_sactipeptide

1

GCATCSIGAACLVDGPIPDFEIAGATGLFGL

31

GC+TCSIG ACL+DGP+PDFE+ G TG+FGL

1

GCSTCSIGVACLIDGPLPDFEVMGITGIFGL

31

69.7% NZ_CP094808.1and 3 others:

NZ_CP094809.1 Sactipeptides: MUA95_RS01320_sactipeptideNZ_CP094813.1 Sactipeptides: MUA84_RS01300_sactipeptideNZ_VKCY01000004.1 Sactipeptides: FNK43_RS05155_sactipeptide

Sactipeptides: MUA11_RS01375_sactipeptide

1

GCATCSIGAACLVDGPIPDFEIAGATGLFGL

31

GC+ C+IGAACL DGPIPDFE+AG TG FG+

1

GCSACAIGAACLADGPIPDFEVAGITGTFGI

31

66.7% NZ_ATDF02000020.1and 1 other:

NZ_KV827785.1 Sactipeptides: HMPREF2580_RS10900_sactipeptide

Sactipeptides: M462_RS08950_sactipeptide

1

GCATCSIGAACLVDGPIPDFEIAGATGLFGL

31

GC+ C++GAACL DGPIPDFE+AG TG FG+

1

GCSACAVGAACLADGPIPDFEVAGITGTFGM

31

63.6% NC_022584.1and 2 others:

NZ_CP047883.1 Sactipeptides: M594_RS05585_sactipeptideNZ_KV802690.1 Sactipeptides: HMPREF2764_RS03300_sactipeptide

Sactipeptides: N596_RS03165_sactipeptide

1

GCATCSIGAACLVDGPIPDFEIAGATGLFGLWG

33

GC+ C+IGA CL DGPIPDFEIAG + +F +G

1

GCSVCAIGAVCLADGPIPDFEIAGVSAVFTAFG

33

63.6% NZ_CP063367.1and 1 other:

NZ_LR134263.1 Sactipeptides: EL101_RS12790_sactipeptide

Sactipeptides: IPU22_RS12430_sactipeptide

1

GCATCSIGAACLVDGPIPDFEIAGATGLFGL

31

GC+ C++GA CL DGPIPDFE+AG TG FG+

1

GCSACAVGAVCLADGPIPDFEVAGITGTFGI

31

60.6% NZ_LGRV01000006.1: Sactipeptides: AEA09_RS16245_sactipeptide

1

GCATCSIGAACLVDGPIPDFEIAGATGLFGLWG

33

GC+ CSIGA CL+ GP+PDFE+A +G+F +WG

1

GCSACSIGAICLITGPVPDFEVASISGIFSVWG

33

54.5% NZ_CP066713.1: Sactipeptides: JGZ50_RS11620_sactipeptide

2

CATCSIGAACLVDGPIPDFEIAGATGLF

29

C+TCSIGAACL+DGP+PDF G F

1

CSTCSIGAACLIDGPLPDFRSHGNYWNF

28

42.4% NZ_PIZD01000012.1: Sactipeptides: allorf_25390_25524_sactipeptide

2

CATCSIGAACLVDGPIPDFEIAGATGLFGLW

32

C+ C++GA CL DGP PD E+ G + G +

3

CSFCAVGAGCLADGPFPDAEVVGVALIAGAF

33

18.2% NZ_CP016898.1: Lassopeptides: BEN76_RS17395_lassopeptide

14

DGPIPDFEIAGATGLF

29

GP+P++ + G G F

3

KGPLPEYFLMGGGGNF

18

17.1% NC_017030.1: Lanthipeptides: allorf_07530736_07530897_lanthipeptide

1

GCATCSIGAACLVDGPI

17

G +I C VDGP+

11

GVLRPAIARPCFVDGPV

27

Sactipeptides

Core peptide predictions

ctg1_371: Putative sactipeptide; RODEO score: 33.0; Core sequence, approximate: GCATCSIGAACLVDGPIPDFEIAGATGLFGLWG

gnlProkkaGABLIMEM_1 - Region 3 - CDPS

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Location: 597,522 - 618,268 nt. (total: 20,747 nt) Show pHMM detection rules used

CDPS: (CDPS or cycdipepsynth)

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NRPS/PKS substrates

NRPS/PKS substrate predictions

gnlProkkaGABLIMEM_1 - Region 4 - NRP-metallophore,NRPS

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Location: 942,893 - 994,670 nt. (total: 51,778 nt) Show pHMM detection rules used

NRP-metallophore: (VibH_like or Cy_tandem or (cds(Condensation and AMP-binding) and ((IBH_Asp and not SBH_Asp) or IBH_His or TBH_Asp or CyanoBH_Asp1 or CyanoBH_Asp2 or IPL or SalSyn or (EntA and EntC) or (GrbD and GrbE) or (FbnL and FbnM) or PvdO or PvdP or (Orn_monoox and not (KtzT or MetRS-like)) or Lys_monoox or VbsL)))
NRPS: cds(Condensation and (AMP-binding or A-OX))

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 4, location 942892 - 994670:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Gly - Thr)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ctg1_973

Search NORINE for peptide: strict or relaxed

AMP-binding (31..435): diOH-Bz

nrpys: diOH-Bz

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Small clusters prediction:: Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
Single AA prediction:: dhb (diOH-Bz)

Stachelhaus prediction details:

Stachelhaus sequence:: PLPAQGVVNK
Nearest Stachelhaus code(s):: diOH-Bz PLPAQGVVNK (100% 8Å match); diOH-Bz or Sal PLPAQGVVNK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

ctg1_975

Search NORINE for peptide: strict or relaxed

AMP-binding (463..861): Gly

nrpys: Gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: gly (Gly)

Stachelhaus prediction details:

Stachelhaus sequence:: DILQLGLIWK
Nearest Stachelhaus code(s):: Gly DILQLGLIWK (97% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1519..1935): Thr

nrpys: Thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: thr (Thr)
Single AA prediction:: thr (Thr)

Stachelhaus prediction details:

Stachelhaus sequence:: DFWNIGMVHK
Nearest Stachelhaus code(s):: Thr DFWNIGMVHK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

gnlProkkaGABLIMEM_2 - Region 1 - NRPS,betalactone

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Location: 65,758 - 104,727 nt. (total: 38,970 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))
betalactone: (HMGL-like and AMP-binding)

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		NT	AA		NT	AA

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 65757 - 104727:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (D-Val) + (Pro - Glu - D-Tyr) + (Ile)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ctg2_97

AMP-binding (13..445): X

nrpys: Asp, Asn, Glu, Gln, Aad

SVM prediction details:

Predicted physicochemical class:: N/A
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: -GLHIAAPVK
Nearest Stachelhaus code(s):: Z-ahmohOrn FGLHIASTCK (56% 8Å match); Ile DGLFIGIPVK (32% 8Å match)
Stachelhaus code match:: 60% (weak)

ctg2_102

Search NORINE for peptide: strict or relaxed

AMP-binding (475..867): Ile

nrpys: Ile

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: ile (Ile)

Stachelhaus prediction details:

Stachelhaus sequence:: DAFFYGITFK
Nearest Stachelhaus code(s):: Ile DAFFYGITFK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

ctg2_103

Search NORINE for peptide: strict or relaxed

AMP-binding (468..865): Pro

nrpys: Pro

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Cyclic aliphatic chain (polar NH2 group) (Pro, Hpr)
Small clusters prediction:: pro (Pro)
Single AA prediction:: pro (Pro)

Stachelhaus prediction details:

Stachelhaus sequence:: DVQFIAHVVK
Nearest Stachelhaus code(s):: Pro DVQFIAHVVK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1499..1900): Glu

nrpys: Glu

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: glu,gln (Glu, Gln)
Single AA prediction:: glu (Glu)

Stachelhaus prediction details:

Stachelhaus sequence:: DAWHFGSVEK
Nearest Stachelhaus code(s):: Glu DAWHFGSVEK (100% 8Å match); Gln DAWHFGSVEK (94% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (2538..2932): Tyr

nrpys: Tyr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: Polar aromatic ring (Tyr, bOH-Tyr)
Single AA prediction:: tyr (Tyr)

Stachelhaus prediction details:

Stachelhaus sequence:: DGTITAEVAK
Nearest Stachelhaus code(s):: Tyr DGTITAEVAK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

ctg2_104

Search NORINE for peptide: strict or relaxed

AMP-binding (386..779): Val

nrpys: Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: val (Val)

Stachelhaus prediction details:

Stachelhaus sequence:: DVFWIGGTFK
Nearest Stachelhaus code(s):: Val DVFWIGGTFK (100% 8Å match); Ala or Val DVFWIGGTFK (91% 8Å match)
Stachelhaus code match:: 100% (strong)

gnlProkkaGABLIMEM_3 - Region 1 - NRPS

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Location: 1 - 15,448 nt. (total: 15,448 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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Predicted core structure(s)

For candidate cluster 1, location 0 - 15448:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Glu - D-Orn) + (Tyr - D-Thr)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ctg3_2

Search NORINE for peptide: strict or relaxed

AMP-binding (474..865): Tyr

nrpys: Tyr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: Polar aromatic ring (Tyr, bOH-Tyr)
Single AA prediction:: tyr (Tyr)

Stachelhaus prediction details:

Stachelhaus sequence:: DGTITAEVAK
Nearest Stachelhaus code(s):: Tyr DGTITAEVAK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1505..1903): Thr

nrpys: Thr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
Small clusters prediction:: thr (Thr)
Single AA prediction:: thr (Thr)

Stachelhaus prediction details:

Stachelhaus sequence:: DFWNIGMVHK
Nearest Stachelhaus code(s):: Thr DFWNIGMVHK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

ctg3_3

Search NORINE for peptide: strict or relaxed

AMP-binding (2..364): Glu

nrpys: Glu

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: glu,gln (Glu, Gln)
Single AA prediction:: glu (Glu)

Stachelhaus prediction details:

Stachelhaus sequence:: DAWHFGGVDK
Nearest Stachelhaus code(s):: Glu DAWHFGGVDK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1003..1408): Orn

nrpys: Orn

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Long positively charged side chain (Orn, Lys, Arg)
Small clusters prediction:: Orn and hydroxy-Orn specific (Orn, OH-Orn)
Single AA prediction:: orn (Orn)

Stachelhaus prediction details:

Stachelhaus sequence:: DVGEIGSIDK
Nearest Stachelhaus code(s):: Orn DVGEIGSIDK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

gnlProkkaGABLIMEM_6 - Region 1 - NRPS

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Location: 193,784 - 219,037 nt. (total: 25,254 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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		NT	AA		NT	AA

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NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 193783 - 219037:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Leu)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ctg6_231

Search NORINE for peptide: strict or relaxed

AMP-binding (469..867): Leu

nrpys: Leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: leu (Leu)

Stachelhaus prediction details:

Stachelhaus sequence:: DAFFLGCVFK
Nearest Stachelhaus code(s):: Leu DAFFLGCVFK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

gnlProkkaGABLIMEM_8 - Region 1 - NRPS

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Location: 175,881 - 204,379 nt. (total: 28,499 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

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NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 175880 - 204379:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Glu - Leu)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ctg8_188

Search NORINE for peptide: strict or relaxed

AMP-binding (466..867): Glu

nrpys: Glu

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: glu,gln (Glu, Gln)
Single AA prediction:: gln (Gln)

Stachelhaus prediction details:

Stachelhaus sequence:: DAKDLGVVDK
Nearest Stachelhaus code(s):: Glu DAKDLGVVDK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1510..1908): Leu

nrpys: Leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: leu (Leu)

Stachelhaus prediction details:

Stachelhaus sequence:: DAFMMGMVFK
Nearest Stachelhaus code(s):: Leu DAFMMGMVFK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (2550..2833): Leu

nrpys: Leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: leu (Leu)

Stachelhaus prediction details:

Stachelhaus sequence:: DAWFLGN--K
Nearest Stachelhaus code(s):: Leu DAWFLGNVVK (82% 8Å match)
Stachelhaus code match:: 80% (moderate)

gnlProkkaGABLIMEM_10 - Region 1 - terpene

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Location: 198,565 - 219,368 nt. (total: 20,804 nt) Show pHMM detection rules used

terpene: (Terpene_synth or Terpene_synth_C or phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Similar known gene clusters from MIBiG 3.1

No matches found.

gnlProkkaGABLIMEM_10 - Region 2 - NRPS,PKS-like,T3PKS,transAT-PKS

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Location: 831,649 - 946,440 nt. (total: 114,792 nt) Show pHMM detection rules used

transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))
PKS-like: (t2pks2 or ksIII)
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)
NRPS: cds(Condensation and (AMP-binding or A-OX))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

Select a gene to view the details available for it

Gene overview

NRPS/PKS domains

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Detailed domain annotation

Selected features only

Show module domains

Similar known gene clusters from MIBiG 3.1

Module view

Legend

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 2, location 831648 - 946440:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Gly - ccmal - ohmal - mal) + (ccmal - mal - ohmal - mal) + (Me-ccmal - ohmal - mal) + (Ala - ccmal - ccmal - Me-ccmal) + (mal - mal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ctg10_875

PKS_AT (4..284): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 95.2
Methoxymalonyl-CoA: 53.7
inactive: 37.1
Methylmalonyl-CoA: 34.6
Propionyl-CoA: 22.3
Ethylmalonyl-CoA: 10.2
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Isobutyryl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

ctg10_877

PKS_AT (7..293): pk

ATSignature: (unknown)

No matches above 50%

minowa: inactive

Prediction, score:

inactive: 27.7
Malonyl-CoA: 22.4
Isobutyryl-CoA: 10.5
Benzoyl-CoA: 9.0
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Propionyl-CoA: 0.0
Methylmalonyl-CoA: 0.0
Methoxymalonyl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

ctg10_878

PKS_AT (4..288): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 66.7%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 96.2
inactive: 40.7
Methoxymalonyl-CoA: 29.2
Methylmalonyl-CoA: 22.2
Propionyl-CoA: 16.2
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

ctg10_884

Search NORINE for peptide: strict or relaxed

CAL_domain (60..471): pk

minowa: fatty_acid

Prediction, score:

fatty_acid: 16.3
NH2: 10.3
shikimic_acid: 0.0
Acetyl-CoA: 0.0
AHBA: 0.0

AMP-binding (1159..1554): Gly

nrpys: Gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: gly (Gly)

Stachelhaus prediction details:

Stachelhaus sequence:: DILQLGMIWK
Nearest Stachelhaus code(s):: Gly DILQLGMIWK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

ctg10_887

Search NORINE for peptide: strict or relaxed

AMP-binding (497..905): Ala

nrpys: Ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DVSNMAIIYK
Nearest Stachelhaus code(s):: Ala DVSNMAIIYK (91% 8Å match)
Stachelhaus code match:: 100% (strong)

gnlProkkaGABLIMEM_12 - Region 1 - lanthipeptide-class-ii

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Location: 1 - 14,096 nt. (total: 14,096 nt) Show pHMM detection rules used

Region on contig edge.

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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Gene overview

KnownClusterBlast

Lanthipeptides

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Similar known gene clusters from MIBiG 3.1

No matches found.

Lanthipeptide predictions

Lanthipeptide(s) for ctg12_3

ctg12_1

Leader:

MQWKNQMENLNAATYNPVGSVLSELTDTEMDTVAGG

ctg12_2

Leader:

MQWKNQMENLNAATYNPVGSVLSELTDTEMDTVAGG

Shared core:

AQALGFTDGNCLASITADCTPWIWGC

Core with dehydrations:

AQALGFDhbDGNCysLADhaIDhbADCysDhbPWIWGCys

MIBiG 3.1 matches for ctg12_1

26.7% BGC0002110 (QKV49893.1): Lanthipeptide: birimositide

1

AQALGFTDGNCLASITADCTP

21

+ ALG G C ++T +C P

9

SNALGNNGGWC--TLTKECQP

27

15.4% BGC0001155 (AGY49587.1): Thiopeptide: GE2270

10

NCLASITADCTP

21

NC+ C+P

3

NCVCGFCCSCSP

14

antiSMASH-DB 4.0 matches for ctg12_1

100.0% NZ_JABRUZ010000012.1: Lanthipeptides: HRF55_RS15035_lanthipeptide

1

AQALGFTDGNCLASITADCTPWIWGC

26

AQALGFTDGNCLASITADCTPWIWGC

1

AQALGFTDGNCLASITADCTPWIWGC

26

96.2% NZ_CP011686.1and 7 others:

NZ_CP011686.1 Lanthipeptides: ABH13_RS05745_lanthipeptideNZ_JALAKW010000008.1 Lanthipeptides: MOB93_RS17005_lanthipeptideNZ_JALAKW010000008.1 Lanthipeptides: MOB93_RS17000_lanthipeptideNZ_JALAME010000008.1 Lanthipeptides: MOC02_RS17820_lanthipeptideNZ_JALAME010000008.1 Lanthipeptides: MOC02_RS17815_lanthipeptideNZ_JALATF010000002.1 Lanthipeptides: MOD44_RS02115_lanthipeptideNZ_JALAYD010000020.1 Lanthipeptides: MOF39_RS20940_lanthipeptide

Lanthipeptides: ABH13_RS05750_lanthipeptide

1

AQALGFTDGNCLASITADCTPWIWGC

26

AQALGFTDGNCLA+ITADCTPWIWGC

1

AQALGFTDGNCLATITADCTPWIWGC

26

88.5% NZ_JH600294.1and 1 other:

NZ_JH600294.1 Lanthipeptides: GYU_RS0115740_lanthipeptide

Lanthipeptides: GYU_RS0115745_lanthipeptide

1

AQALGFTDGNCLASITADCTPWIWGC

26

AQALGFTDGNCL +ITADCTPW+WGC

1

AQALGFTDGNCLTTITADCTPWLWGC

26

with 14 more sequence matches

85.2% NZ_NVFD01000061.1: Lanthipeptides: COL35_RS24665_lanthipeptide

1

AQALGFTDGNCLASITADCTPWIWGC

26

AQALGFTDGNCLA+ITADCTPWI C

1

AQALGFTDGNCLATITADCTPWIGIC

26

81.5% NZ_CM000728.1and 4 others:

NZ_JH792121.1 Lanthipeptides: IGO_RS31525_lanthipeptideNZ_JH792158.1 Lanthipeptides: IK3_RS31375_lanthipeptideNZ_NUQX01000026.1 Lanthipeptides: COE81_RS20175_lanthipeptideNZ_NVFD01000061.1 Lanthipeptides: COL35_RS30950_lanthipeptide

Lanthipeptides: BCERE0017_RS32175_lanthipeptide

1

AQALGFTDGNCLASITADCTPWIWGC

26

AQALGFTDGNCLA+ITAD TPWI C

1

AQALGFTDGNCLATITADYTPWIGIC

26

77.8% NZ_CM000728.1and 2 others:

NZ_JH792121.1 Lanthipeptides: IGO_RS26860_lanthipeptideNZ_NUQX01000026.1 Lanthipeptides: COE81_RS20170_lanthipeptide

Lanthipeptides: BCERE0017_RS28125_lanthipeptide

1

AQALGFTDGNCLASITADCTPWIWGC

26

AQALGFTDGNCLA+ITADCT W+ C

1

AQALGFTDGNCLATITADCTDWLPIC

26

76.9% NZ_BMLN01000009.1: Lanthipeptides: IEX28_RS15335_lanthipeptide

1

AQALGFTDGNCLASITADCTPWIWGC

26

A A GFTDGNCL SITADCTPW+ C

1

ATAQGFTDGNCLKSITADCTPWLGLC

26

75.9% NZ_CM000728.1and 3 others:

NZ_JH792121.1 Lanthipeptides: allorf_129150_129275_lanthipeptideNZ_NUQX01000026.1 Lanthipeptides: COE81_RS20180_lanthipeptideNZ_NVFD01000061.1 Lanthipeptides: COL35_RS24660_lanthipeptide

Lanthipeptides: BCERE0017_RS28130_lanthipeptide

1

AQALGFTDGNCLASITADCTPWIWGC

26

QALGFTDGNCL SITADCTPW+ GC

1

VQALGFTDGNCLYSITADCTPWLLGC

26

74.1% NZ_CP058552.1: Lanthipeptides: HW560_RS06640_lanthipeptide

1

AQALGFTDGNCLASITADCTP-WIWGC

26

AQA GFTDGNC+++ITADCTP W W C

1

AQAQGFTDGNCVSTITADCTPGWTWVC

27

48.3% NZ_CP011420.1: Lanthipeptides: VK72_RS10865_lanthipeptide

3

ALGFTDGNCLASITADCTP--WIWGC

26

A GFTDG+C+ +ITA C +I GC

3

AYGFTDGDCIRTITAGCDTVCYIKGC

28

30.8% NZ_CP093846.1and 2 others:

NZ_QOIM01000024.1 Lanthipeptides: DQ392_RS34305_lanthipeptideNZ_QOIN01000048.1 Lanthipeptides: DTL70_RS33655_lanthipeptide

Lanthipeptides: MMF93_RS21475_lanthipeptide

8

DGNCLASITADCTPWIWGC

26

+G C S T+ CT + GC

2

NGGCATSRTSLCTDTLSGC

20

30.8% NZ_PYGA01000041.1and 1 other:

NZ_PYGA01000041.1 Lanthipeptides: CLV63_RS33905_lanthipeptide

Lanthipeptides: CLV63_RS33905_lanthipeptide

8

DGNCLASITADCTPWIWGC

26

+G C S T+ CT + GC

4

NGGCETSRTSLCTDTLSGC

22

25.0% NZ_CP051884.1and 2 others:

NZ_CP051884.1 Lanthipeptides: allorf_3265908_3266039_lanthipeptideNZ_CP051884.1 Lanthipeptides: allorf_3265908_3266039_lanthipeptide

Lanthipeptides: allorf_3265908_3266039_lanthipeptide

8

DGNCLASITADCTPW

22

DG A+ T D PW

7

DGVTRAAQTGDPRPW

21

22.4% NZ_KZ859514.1: Lanthipeptides: DPQ64_RS18690_lanthipeptide

4

LGFTDGNCLASITADCTPW

22

LG TD CL S T DC P+

29

LGCTD-TCLCSTTVDCDPY

46

19.2% NZ_BMRY01000010.1and 81 others:

NZ_BMRY01000010.1 Lanthipeptides: IE140_RS27680_lanthipeptideNZ_BMRY01000010.1 Lanthipeptides: IE140_RS27680_lanthipeptideNZ_BMRY01000010.1 Lanthipeptides: IE140_RS27680_lanthipeptideNZ_BMSZ01000004.1 Lanthipeptides: IE135_RS08610_lanthipeptideNZ_BMSZ01000004.1 Lanthipeptides: IE135_RS08610_lanthipeptideNZ_BMSZ01000004.1 Lanthipeptides: IE135_RS08610_lanthipeptideNZ_BMSZ01000004.1 Lanthipeptides: IE135_RS08610_lanthipeptideNZ_BNBJ01000007.1 Lanthipeptides: IE304_RS13825_lanthipeptideNZ_BNBJ01000007.1 Lanthipeptides: IE304_RS13825_lanthipeptideNZ_BNBJ01000007.1 Lanthipeptides: IE304_RS13825_lanthipeptideNZ_BNBJ01000007.1 Lanthipeptides: IE304_RS13825_lanthipeptideNZ_CP010833.1 Lanthipeptides: TK78_RS36080_lanthipeptideNZ_CP010833.1 Lanthipeptides: TK78_RS36080_lanthipeptideNZ_CP010833.1 Lanthipeptides: TK78_RS36080_lanthipeptideNZ_CP010833.1 Lanthipeptides: TK78_RS36080_lanthipeptideNZ_CP013738.1 Lanthipeptides: WQO_RS36380_lanthipeptideNZ_CP013738.1 Lanthipeptides: WQO_RS36380_lanthipeptideNZ_CP013738.1 Lanthipeptides: WQO_RS36380_lanthipeptideNZ_CP013738.1 Lanthipeptides: WQO_RS36380_lanthipeptideNZ_CP021707.1 Lanthipeptides: CCZ36_RS34740_lanthipeptideNZ_CP021707.1 Lanthipeptides: CCZ36_RS34740_lanthipeptideNZ_CP021707.1 Lanthipeptides: CCZ36_RS34740_lanthipeptideNZ_CP021707.1 Lanthipeptides: CCZ36_RS34740_lanthipeptideNZ_CP029361.1 Lanthipeptides: DIJ69_RS34965_lanthipeptideNZ_CP029361.1 Lanthipeptides: DIJ69_RS34965_lanthipeptideNZ_CP029361.1 Lanthipeptides: DIJ69_RS34965_lanthipeptideNZ_CP029361.1 Lanthipeptides: DIJ69_RS34965_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS11695_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS11695_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS11695_lanthipeptideNZ_CP079114.1 Lanthipeptides: KV381_RS11695_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS06820_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS06820_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS06820_lanthipeptideNZ_CP084357.1 Lanthipeptides: LEL86_RS06820_lanthipeptideNZ_CP090837.1 Lanthipeptides: LZ559_RS11615_lanthipeptideNZ_CP090837.1 Lanthipeptides: LZ559_RS11615_lanthipeptideNZ_CP090837.1 Lanthipeptides: LZ559_RS11615_lanthipeptideNZ_CP090837.1 Lanthipeptides: LZ559_RS11615_lanthipeptideNZ_CP117709.1 Lanthipeptides: PSQ21_RS10520_lanthipeptideNZ_DS999644.1 Lanthipeptides: SSGG_RS37575_lanthipeptideNZ_JAJUKK010000002.1 Lanthipeptides: LXH09_RS05290_lanthipeptideNZ_JAJUKK010000002.1 Lanthipeptides: LXH09_RS05290_lanthipeptideNZ_JAJUKK010000002.1 Lanthipeptides: LXH09_RS05290_lanthipeptideNZ_JAJUKK010000002.1 Lanthipeptides: LXH09_RS05290_lanthipeptideNZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27525_lanthipeptideNZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27525_lanthipeptideNZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27525_lanthipeptideNZ_JALDPQ010000065.1 Lanthipeptides: MQC87_RS27525_lanthipeptideNZ_JAMFLF010000007.1 Lanthipeptides: M1212_RS18745_lanthipeptideNZ_JAMFLF010000007.1 Lanthipeptides: M1212_RS18745_lanthipeptideNZ_JAMFLF010000007.1 Lanthipeptides: M1212_RS18745_lanthipeptideNZ_JAMFLF010000007.1 Lanthipeptides: M1212_RS18745_lanthipeptideNZ_JNLT01000008.1 Lanthipeptides: CD02_RS38865_lanthipeptideNZ_JNLT01000008.1 Lanthipeptides: CD02_RS38865_lanthipeptideNZ_JNLT01000008.1 Lanthipeptides: CD02_RS38865_lanthipeptideNZ_JNLT01000008.1 Lanthipeptides: CD02_RS38865_lanthipeptideNZ_KL573557.1 Lanthipeptides: BG84_RS1000000140065_lanthipeptideNZ_KZ679082.1 Lanthipeptides: allorf_2505302_2505508_lanthipeptideNZ_KZ679082.1 Lanthipeptides: allorf_2505302_2505508_lanthipeptideNZ_KZ679082.1 Lanthipeptides: allorf_2505302_2505508_lanthipeptideNZ_KZ819154.1 Lanthipeptides: allorf_5241449_5241619_lanthipeptideNZ_KZ819154.1 Lanthipeptides: allorf_5241449_5241619_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS35630_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS35630_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS35630_lanthipeptideNZ_KZ819178.1 Lanthipeptides: DBP20_RS35630_lanthipeptideNZ_LACR01000026.1 Lanthipeptides: YW5_RS36735_lanthipeptideNZ_LACR01000026.1 Lanthipeptides: YW5_RS36735_lanthipeptideNZ_LACR01000026.1 Lanthipeptides: YW5_RS36735_lanthipeptideNZ_LACR01000026.1 Lanthipeptides: YW5_RS36735_lanthipeptideNZ_LIXK01000002.1 Lanthipeptides: AMK23_RS37800_lanthipeptideNZ_LIXK01000002.1 Lanthipeptides: AMK23_RS37800_lanthipeptideNZ_LIXK01000002.1 Lanthipeptides: AMK23_RS37800_lanthipeptideNZ_LIXK01000002.1 Lanthipeptides: AMK23_RS37800_lanthipeptideNZ_NNBN01000010.1 Lanthipeptides: CG717_RS33255_lanthipeptideNZ_NNBN01000010.1 Lanthipeptides: CG717_RS33255_lanthipeptideNZ_WWGD01000003.1 Lanthipeptides: GTY72_RS37120_lanthipeptideNZ_WWGD01000003.1 Lanthipeptides: GTY72_RS37120_lanthipeptideNZ_WWGD01000003.1 Lanthipeptides: GTY72_RS37120_lanthipeptideNZ_WWGD01000003.1 Lanthipeptides: GTY72_RS37120_lanthipeptide

Lanthipeptides: IE140_RS27680_lanthipeptide

7

TDGNCLASITA

17

TDGNC++ ++

3

TDGNCISVLSV

13

16.7% NZ_CP084033.1: Lanthipeptides: LAZ93_RS17080_lanthipeptide

1

AQALGFTDGNCLASI

15

+ G T GNC+++I

18

TEHCGKTQGNCISNI

32

16.2% NZ_CP020567.1: Thiopeptides: B6264_RS31925_thiopeptide

6

FTDGNCLASIT

16

TDGN L+S++

2

LTDGNALSSVS

12

allorf_000530_000595

Leader:

MSNLNGS

Core:

PLRYYCELTCSRIK

Core with dehydrations:

PLRYYCysELDhbCysDhaRIK

antiSMASH-DB 4.0 matches for allorf_000530_000595

92.9% NZ_CP011686.1: Lanthipeptides: allorf_1118881_1119048_lanthipeptide

1

PLRYYCELTCSRIK

14

PLRYYCE TCSRIK

1

PLRYYCESTCSRIK

14

85.7% NZ_JALAKW010000008.1: Lanthipeptides: allorf_071714_071779_lanthipeptide

1

PLRYYCELTCSRIK

14

PLRYYCE TC RIK

1

PLRYYCESTCFRIK

14

85.7% NZ_JALAME010000008.1and 2 others:

NZ_JALATF010000002.1 Lanthipeptides: allorf_0066569_0066634_lanthipeptideNZ_JALAYD010000020.1 Lanthipeptides: allorf_21886_21951_lanthipeptide

Lanthipeptides: allorf_063190_063255_lanthipeptide

1

PLRYYCELTCSRIK

14

PLRYYCE TCS IK

1

PLRYYCESTCSGIK

14

with 3 more sequence matches

85.7% NZ_JH600294.1: Lanthipeptides: allorf_051667_051822_lanthipeptide

2

LRYYCELTCSRIK

14

LRYYCE TCSRIK

2

LRYYCESTCSRIK

14

33.3% NZ_CP119804.1: Lanthipeptides: allorf_2887586_2887705_lanthipeptide

1

PLRYYCEL

8

PLR++C L

2

PLRHFCSL

9

32.4% NZ_CM000728.1and 3 others:

NZ_JH792121.1 Lanthipeptides: allorf_128736_128903_lanthipeptideNZ_NUQX01000026.1 Lanthipeptides: allorf_180008_180175_lanthipeptideNZ_NVFD01000061.1 Lanthipeptides: allorf_18526_18693_lanthipeptide

Lanthipeptides: allorf_5591499_5591666_lanthipeptide

1

PLRYYCELTCSRIK

14

PLRYYCE T SRIK

20

PLRYYCESTSSRIK

33

allorf_009492_009611

Leader:

MSIQVSVKNTDADDLYMG

Core:

CIHVAAVAEQIKEQQRMKKAS

Core with dehydrations:

CysIHVAAVAEQIKEQQRMKKADha

antiSMASH-DB 4.0 matches for allorf_009492_009611

100.0% NZ_JALAKW010000008.1and 4 others:

NZ_JALAME010000008.1 Lanthipeptides: allorf_052618_052737_lanthipeptideNZ_JALATF010000002.1 Lanthipeptides: allorf_0055998_0056117_lanthipeptideNZ_JALAYD010000020.1 Lanthipeptides: allorf_32404_32523_lanthipeptideNZ_JH600294.1 Lanthipeptides: allorf_062075_062194_lanthipeptide

Lanthipeptides: allorf_061142_061261_lanthipeptide

1

CIHVAAVAEQIKEQQRMKKAS

21

CIHVAAVAEQIKEQQRMKKAS

1

CIHVAAVAEQIKEQQRMKKAS

21

16.0% NZ_KQ061217.1: Lanthipeptides: allorf_2978446_2978673_lanthipeptide

3

HVAAVAEQIKEQQRMKKA

20

HV+ VA + + +QRM+ A

28

HVSMVASRQRHRQRMRFA

45

allorf_010054_010287

Leader:

MRSFVKVKWCQQKVVHFM

Core:

RLLVAPVIHCMSKNRSLSQDFGFVYISLNLLNAQSNAGALSVVRTAGSPNVLTNLFIKA

Core with dehydrations:

RLLVAPVIHCysMDhaKNRDhaLDhaQDFGFVYIDhaLNLLNAQDhaNAGALDhaVVRDhbAGDhaPNVLDhbNLFIKA

allorf_010179_010328

Leader:

MDIQLRKKRDHQAAYA

Core:

FMKRLVKTFGEPAVLTTDKAPALLCAFNKLREI

Core with dehydrations:

FMKRLVKDhbFGEPAVLDhbDhbDKAPALLCysAFNKLREI

antiSMASH-DB 4.0 matches for allorf_010179_010328

15.6% NZ_QLLX01000002.1and 1 other:

NZ_QLLX01000002.1 Lanthipeptides: allorf_337484_337657_lanthipeptide

Lanthipeptides: allorf_337484_337657_lanthipeptide

4

RLVKTFGEP

12

RLVK +GEP

11

RLVKPYGEP

19

12.7% NZ_CP029607.1: Lanthipeptides: allorf_6468650_6468883_lanthipeptide

3

KRLVKTFGEPAVLTTDKAPA

22

+R + P+V TTD PA

15

ERPPASVRPPSVWTTDAPPA

34

allorf_010416_010550

Leader:

MNVFIFLLPNLIDKVSVFM

Core:

NPAHDDCWVNRNTTLFQDFGYITIA

Core with dehydrations:

NPAHDDCysWVNRNDhbDhbLFQDFGYIDhbIA

MIBiG 3.1 matches for allorf_010416_010550

17.9% BGC0000517 (BAB04173.1): Lanthipeptide: haloduracin β or haloduracin α

8

WVNRNTTLFQDFGYITI

24

W N + L Y T+

3

WYNISCRLGNKGAYCTL

19

antiSMASH-DB 4.0 matches for allorf_010416_010550

26.9% NZ_LMFT01000038.1and 1 other:

NZ_LMFT01000038.1 Lanthipeptides: allorf_017162_017272_lanthipeptide

Lanthipeptides: allorf_017162_017272_lanthipeptide

2

PAHDDCWVNRNTTL

15

PAH+ WV R T +

8

PAHEAAWV-RGTEM

20

12.5% NZ_CP011924.1: Lanthipeptides: PPIS_RS14760_lanthipeptide

6

DCWVNRN

12

DCW RN

23

DCWTGRN

29

12.5% NZ_CP022522.1and 5 others:

NZ_CP047240.1 Lanthipeptides: GSF13_RS24110_lanthipeptideNZ_CP074587.1 Lanthipeptides: KIJ96_RS09175_lanthipeptideNZ_JAFEKQ010000087.1 Lanthipeptides: JQ508_RS22480_lanthipeptideNZ_JAKKCU010000007.1 Lanthipeptides: L3V39_RS13170_lanthipeptideNZ_JH650747.1 Lanthipeptides: UY7_RS0119240_lanthipeptide

Lanthipeptides: PNC201_RS17775_lanthipeptide

4

HDDCWVNRNTTLFQ

17

+ DCW RN + +

21

YGDCWTGRNRSCRE

34

with 1 more sequence matches

11.4% NZ_CP021646.1and 5 others:

NZ_CP024625.1 Lanthipeptides: CTT31_RS17865_lanthipeptideNZ_CP031759.1 Lanthipeptides: D0N37_RS18595_lanthipeptideNZ_CP047238.1 Lanthipeptides: GSF04_RS22995_lanthipeptideNZ_CP068023.1 Lanthipeptides: JJQ94_RS23815_lanthipeptideNZ_CP081860.1 Lanthipeptides: K5642_RS18070_lanthipeptide

Lanthipeptides: B1L02_RS18305_lanthipeptide

4

HDDCWVNRN

12

+ DCW RN

25

YGDCWTGRN

33

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Lanthipeptides

Core peptide predictions

ctg12_1 - Class II

Cleavage pHMM score: 4.60

RODEO score: 0

Monoisotopic mass: 2641.2 Da

Molecular weight: 2643.0 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 2661.0 Da N = 1

ctg12_2 - Class II

Cleavage pHMM score: 4.60

RODEO score: 0

Monoisotopic mass: 2641.2 Da

Molecular weight: 2643.0 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 2661.0 Da N = 1

allorf_000530_000595 - Class II

Cleavage pHMM score: -6.70

RODEO score: 0

Monoisotopic mass: 1707.9 Da

Molecular weight: 1709.0 Da

Number of bridges: 2

allorf_009492_009611 - Class II

Cleavage pHMM score: -6.40

RODEO score: 0

Monoisotopic mass: 2349.3 Da

Molecular weight: 2350.8 Da

Number of bridges: 1

allorf_010054_010287 - Class II

Cleavage pHMM score: -3.80

RODEO score: 0

Monoisotopic mass: 6165.4 Da

Molecular weight: 6169.1 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 6187.2 Da N = 1; 6205.2 Da N = 2; 6223.2 Da N = 3; 6241.2 Da N = 4; 6259.2 Da N = 5; 6277.3 Da N = 6; 6295.3 Da N = 7; 6313.3 Da N = 8

allorf_010179_010328 - Class II

Cleavage pHMM score: -2.50

RODEO score: 0

Monoisotopic mass: 3666.1 Da

Molecular weight: 3668.4 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 3686.4 Da N = 1; 3704.4 Da N = 2

allorf_010416_010550 - Class II

Cleavage pHMM score: -4.50

RODEO score: 0

Monoisotopic mass: 2856.3 Da

Molecular weight: 2858.1 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 2876.1 Da N = 1; 2894.1 Da N = 2

gnlProkkaGABLIMEM_12 - Region 2 - T3PKS

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Location: 126,308 - 167,405 nt. (total: 41,098 nt) Show pHMM detection rules used

T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

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Gene overview

NRPS/PKS domains

KnownClusterBlast

Gene/CDS overview

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Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Detailed domain annotation

Selected features only

Show module domains

Similar known gene clusters from MIBiG 3.1

gnlProkkaGABLIMEM_12 - Region 3 - terpene

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Location: 215,862 - 237,760 nt. (total: 21,899 nt) Show pHMM detection rules used

terpene: (Terpene_synth or Terpene_synth_C or phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

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Gene details

Select a gene to view the details available for it

Gene overview

KnownClusterBlast

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Similar known gene clusters from MIBiG 3.1

No matches found.

gnlProkkaGABLIMEM_17 - Region 1 - NRPS

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Location: 1 - 9,889 nt. (total: 9,889 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

NRPS/PKS domains

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Detailed domain annotation

Selected features only

Show module domains

Similar known gene clusters from MIBiG 3.1

Module view

Legend

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 9889:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Val - Asp)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ctg17_2

Search NORINE for peptide: strict or relaxed

AMP-binding (470..864): Val

nrpys: Val

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: val (Val)

Stachelhaus prediction details:

Stachelhaus sequence:: DAFWIGGTFK
Nearest Stachelhaus code(s):: Val DAFWIGGTFK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1501..1904): Asp

nrpys: Asp

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: asp,asn (Asp, Asn)
Single AA prediction:: asp (Asp)

Stachelhaus prediction details:

Stachelhaus sequence:: DLTKVGHIGK
Nearest Stachelhaus code(s):: Asp DLTKVGHIGK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (2546..2829): Leu

nrpys: Leu

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: leu (Leu)

Stachelhaus prediction details:

Stachelhaus sequence:: DAWFLGN--K
Nearest Stachelhaus code(s):: Leu DAWFLGNVVK (82% 8Å match)
Stachelhaus code match:: 80% (moderate)