LOCUS gnlProkkaKNDAHMHA_3 25587 bp DNA linear UNK 01-JAN-1980 DEFINITION gnl|Prokka|KNDAHMHA_3. ACCESSION gnlProkkaKNDAHMHA_3 VERSION gnlProkkaKNDAHMHA_3 KEYWORDS . SOURCE ORGANISM . COMMENT ##antiSMASH-Data-START## Version :: 7.1.0 Run date :: 2025-04-28 19:32:38 Original ID :: gnl|Prokka|KNDAHMHA_3 NOTE: This is a single region extracted from a larger record! Orig. start :: 0 Orig. end :: 25587 ##antiSMASH-Data-END## FEATURES Location/Qualifiers protocluster 1..25587 /aStool="rule-based-clusters" /category="NRPS" /contig_edge="True" /core_location="[1759:5587]" /cutoff="20000" /detection_rule="cds(Condensation and (AMP-binding or A-OX))" /neighbourhood="20000" /product="NRPS" /protocluster_number="1" /tool="antismash" proto_core 1760..5587 /aStool="rule-based-clusters" /tool="antismash" /cutoff="20000" /detection_rule="cds(Condensation and (AMP-binding or A-OX))" /neighbourhood="20000" /product="NRPS" /protocluster_number="1" cand_cluster 1..25587 /SMILES="NC(CC(C)C)C(=O)O" /candidate_cluster_number="1" /contig_edge="True" /detection_rules="cds(Condensation and (AMP-binding or A-OX))" /kind="single" /product="NRPS" /protoclusters="1" /tool="antismash" region 1..25587 /candidate_cluster_numbers="1" /contig_edge="True" /product="NRPS" /region_number="1" /rules="cds(Condensation and (AMP-binding or A-OX))" /tool="antismash" CDS 2..1723 /NRPS_PKS="Domain: PCP (29-97). E-value: 2.9e-28. Score: 89.8. Matches aSDomain: nrpspksdomains_ctg3_1_PCP.1" /NRPS_PKS="Domain: Epimerization (107-410). E-value: 9e-162. Score: 531.4. Matches aSDomain: nrpspksdomains_ctg3_1_Epimerization.1" /NRPS_PKS="Domain: TIGR01720 (414-563). E-value: 1.1e-54. Score: 176.3. Matches aSDomain: nrpspksdomains_ctg3_1_TIGR01720.1" /gene_functions="biosynthetic-additional (rule-based-clusters) PP-binding" /gene_functions="biosynthetic-additional (rule-based-clusters) Condensation" /gene_functions="biosynthetic-additional (smcogs) SMCOG1127:condensation domain-containing protein (Score: 135.1; E-value: 6.5e-41)" /gene_kind="biosynthetic-additional" /locus_tag="ctg3_1" /sec_met_domain="PP-binding (E-value: 1.1e-17, bitscore: 58.1, seeds: 164, tool: rule-based-clusters)" /sec_met_domain="Condensation (E-value: 1e-85, bitscore: 281.2, seeds: 42, tool: rule-based-clusters)" /transl_table=11 /translation="MNGKVDRKALPEPDIEAGSGEYKAPTTDMEELLAGIWQDVLGMSE VGVTDNFFSLGGDSIKGIQMASRLNQHGWKLEMKDLFQHPTIEELTQYVERAEGKQADQ GPVEGEVILTPIQRWFFEKNFTNKHHWNQSVMLHAAKGFDPERVEKTLQALIEHHDALR MVYREENGDIVQAYQPISESKVSFEIVDLYGSDEEMLRSQIKILANKLQSSLDLQNGPL LKAEQYRTEAGDHLLIAVHHLVVDGVSWRILLEDFASGYMQAEKEESLVFPQKTNSFKD WAEELAAFSQSAHLLQQAEYWSQIAAEQVSPLPKDCKTEQRIVKDTSSVLCELTEEDTK HLLTDVHQPYGTEINDILLSALGLTMKEWTKGAKIGINLEGHGREDIIPNVNISRTVGW FTAQYPVVLDISDADASAVIKTVKENLRRIPDKGVGYGILRYFTETAETKGFTPEISFN YLGQFDSEVKTDFFEPSAFDMGRQVSGESEALYALSFSGMIRNGRFVLSCSYNEKEFER ATVEEQMERFKENLLMLIRHCTEKEDKEFTPSDFSAEDLEMDEMGDIFDMLEENLK" aSDomain 89..292 /aSDomain="PCP" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ctg3_1_PCP.1" /evalue="2.90E-28" /label="ctg3_1_PCP.1" /locus_tag="ctg3_1" /protein_end="97" /protein_start="29" /score="89.8" /tool="antismash" /translation="EELLAGIWQDVLGMSEVGVTDNFFSLGGDSIKGIQMASRLNQHGW KLEMKDLFQHPTIEELTQYVERA" aSModule 89..1690 /domains="nrpspksdomains_ctg3_1_PCP.1" /domains="nrpspksdomains_ctg3_1_Epimerization.1" /domains="nrpspksdomains_ctg3_1_TIGR01720.1" /incomplete /locus_tags="ctg3_1" /tool="antismash" /type="unknown" aSDomain 323..1231 /aSDomain="Epimerization" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ctg3_1_Epimerization.1" /evalue="9.00E-162" /label="ctg3_1_Epimerization.1" /locus_tag="ctg3_1" /protein_end="410" /protein_start="107" /score="531.4" /tool="antismash" /translation="EGEVILTPIQRWFFEKNFTNKHHWNQSVMLHAAKGFDPERVEKTL QALIEHHDALRMVYREENGDIVQAYQPISESKVSFEIVDLYGSDEEMLRSQIKILANKL QSSLDLQNGPLLKAEQYRTEAGDHLLIAVHHLVVDGVSWRILLEDFASGYMQAEKEESL VFPQKTNSFKDWAEELAAFSQSAHLLQQAEYWSQIAAEQVSPLPKDCKTEQRIVKDTSS VLCELTEEDTKHLLTDVHQPYGTEINDILLSALGLTMKEWTKGAKIGINLEGHGREDII PNVNISRTVGWFTAQYPVVLDI" CDS_motif 338..367 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg3_1_0001" /evalue="3.50E-05" /label="NRPS-E1" /locus_tag="ctg3_1" /protein_end="122" /protein_start="112" /score="16.4" /tool="antismash" /translation="LTPIQRWFFE" CDS_motif 428..502 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg3_1_0002" /evalue="2.10E-06" /label="C2_LCL_024-062" /locus_tag="ctg3_1" /protein_end="167" /protein_start="142" /score="20.2" /tool="antismash" /translation="FDPERVEKTLQALIEHHDALRMVYR" CDS_motif 707..772 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg3_1_0003" /evalue="3.70E-12" /label="NRPS-E2" /locus_tag="ctg3_1" /protein_end="257" /protein_start="235" /score="38.3" /tool="antismash" /translation="LLIAVHHLVVDGVSWRILLEDF" CDS_motif 1175..1225 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg3_1_0004" /evalue="1.40E-08" /label="NRPS-E5" /locus_tag="ctg3_1" /protein_end="408" /protein_start="391" /score="26.7" /tool="antismash" /translation="NISRTVGWFTAQYPVVL" aSDomain 1244..1690 /aSDomain="TIGR01720" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ctg3_1_TIGR01720.1" /evalue="1.10E-54" /label="ctg3_1_TIGR01720.1" /locus_tag="ctg3_1" /protein_end="563" /protein_start="414" /score="176.3" /tool="antismash" /translation="ASAVIKTVKENLRRIPDKGVGYGILRYFTETAETKGFTPEISFNY LGQFDSEVKTDFFEPSAFDMGRQVSGESEALYALSFSGMIRNGRFVLSCSYNEKEFERA TVEEQMERFKENLLMLIRHCTEKEDKEFTPSDFSAEDLEMDEMGD" CDS_motif 1265..1324 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg3_1_0005" /evalue="8.60E-12" /label="NRPS-E6" /locus_tag="ctg3_1" /protein_end="441" /protein_start="421" /score="37.1" /tool="antismash" /translation="VKENLRRIPDKGVGYGILRY" CDS_motif 1358..1387 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg3_1_0006" /evalue="1.50E-03" /label="NRPS-E7" /locus_tag="ctg3_1" /protein_end="462" /protein_start="452" /score="10.9" /tool="antismash" /translation="PEISFNYLGQ" aSDomain 1760..1855 /aSDomain="NRPS-COM_Nterm" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ctg3_2_NRPS-COM_Nterm.1" /evalue="1.40E-16" /label="ctg3_2_NRPS-COM_Nterm.1" /locus_tag="ctg3_2" /protein_end="32" /protein_start="0" /score="51.3" /tool="antismash" /translation="MSQFSKDQVQDMYYLSPMQEGMLFHAILNPGQ" CDS 1760..5587 /NRPS_PKS="Domain: NRPS-COM_Nterm (0-32). E-value: 1.4e-16. Score: 51.3. Matches aSDomain: nrpspksdomains_ctg3_2_NRPS-COM_Nterm.1" /NRPS_PKS="Domain: Condensation_DCL (9-308). E-value: 9.8e-119. Score: 387.7. Matches aSDomain: nrpspksdomains_ctg3_2_Condensation_DCL.1" /NRPS_PKS="Domain: AMP-binding (469-867). E-value: 6e-113. Score: 369.3. Matches aSDomain: nrpspksdomains_ctg3_2_AMP-binding.1" /NRPS_PKS="Domain: PCP (973-1042). E-value: 1.5e-25. Score: 81.1. Matches aSDomain: nrpspksdomains_ctg3_2_PCP.1" /NRPS_PKS="Domain: Thioesterase (1060-1265). E-value: 8.1e-37. Score: 119.7. Matches aSDomain: nrpspksdomains_ctg3_2_Thioesterase.1" /gene_functions="biosynthetic (rule-based-clusters) NRPS: AMP-binding" /gene_functions="biosynthetic (rule-based-clusters) NRPS: Condensation" /gene_functions="biosynthetic-additional (rule-based-clusters) PP-binding" /gene_functions="biosynthetic-additional (smcogs) SMCOG1127:condensation domain-containing protein (Score: 332.2; E-value: 1e-100)" /gene_kind="biosynthetic" /locus_tag="ctg3_2" /sec_met_domain="Condensation (E-value: 3.2e-93, bitscore: 305.8, seeds: 42, tool: rule-based-clusters)" /sec_met_domain="AMP-binding (E-value: 2.1e-123, bitscore: 405.7, seeds: 400, tool: rule-based-clusters)" /sec_met_domain="PP-binding (E-value: 8e-18, bitscore: 58.6, seeds: 164, tool: rule-based-clusters)" /transl_table=11 /translation="MSQFSKDQVQDMYYLSPMQEGMLFHAILNPGQSFYLEQITMKVKG SLNIKCLEESMNVIMDRYDVFRTVFIHEKVKRPVQVVLKKRQFHIEEIDLTHLTGSEQT AKINEYKEQDKIRGFDLTRDIPMRAAIFKKAEESFEWVWSYHHIILDGWCFGIVVQDLF KVYNALREQKPYSLPPVKPYKDYIKWLEKQDKQASLHYWREYLEDFEGQTTFAEQRKKQ KDGYEPKELLFSLPEAETKAFTELAKSQHTTLSTALQAVWSVLISRYQQSGDLAFGTVV SGRPAEIKGVEHMVGLFINVVPRRVKLSEGITFNGLLKQLQEQSLQSEPHQYVPLYDIQ SQADQPKLIDHIIVFENYPLQDAKNEESSENGFDMVDVHVFEKSNYDLNLMASPGDEML IKLAYNENVFDEAFILRLKSQLLTAIQQLIQNPDQPVSTINLVDDREREFLLTGLNPPA QAHETKPLTDWFKEAVNVNPDAPALTYSGQTLSYRELDEEANRLARRLQKQGAGKGSVV ALYTKRSLELVIGILGVLKAGAAYLPVDPKLPEDRISYMLADSAAACLLTHQEMKEQAA ELPYTGTTLFIDDQTRFEEQASDPANAIDPNDPAYIMYTSGTTGKPKGNMTTHANIQGL VKHVDYMAFSEKDTFLSVSNYAFDAFTFDFYASMLNAARLIIADEHTLLDTERLTDLIL QENVNVMFATTALFNLLTDAGEDWMKGLRCILFGGERASVPHVRKALRVMGPGKLINCY GPTEGTVFATAHVVHDLPDSISSLPIGKPISNASVYILNEQSQLQPFGAIGELCISGMG VSKGYVNRADLTKEKFIKNPFKPGETLYRTGDLARWLPDGTIEYVGRIDDQVKIRGHRI ELEEIEKQLQEYPGVKDAVVVADRPESGDASINAYLVNRTQLSAEDVKAHLKKQLPAYM VPQTFTFLDELPLTTNGKVNKRLLPKPDQDQLAEEWIGPRNEMEETIAQIWSEVLGRKQ IGIHDDFFALGGHSLKAMTAASRIKKELGIDLPVKLLFEAPTIAGISAYVKNGGPDGMQ DVTIMNQDQEQIIFAFPPVLGYGLMYQNLSSRLPSYKLCAFDFIEEEDRLDRYADLIQK LQPEGPLTLFGYSAGCSLAFEAAKKLEEQGRIVQRIIMVDSYKKRGVSDLDGRTVESDV EALMNVNRDNEALNSEAVKQGLKQKTHAFYSYYVNLISTGQVKADIDLLTSGADFDMPE WLASWEEATTGAYRMKRGFGSHAEMLQGETLDRNAEILLEFLNTQTVTVS" aSDomain 1787..2683 /aSDomain="Condensation" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ctg3_2_Condensation_DCL.1" /domain_subtypes="Condensation_DCL" /evalue="9.80E-119" /label="ctg3_2_Condensation_DCL.1" /locus_tag="ctg3_2" /protein_end="308" /protein_start="9" /score="387.7" /tool="antismash" /translation="QDMYYLSPMQEGMLFHAILNPGQSFYLEQITMKVKGSLNIKCLEE SMNVIMDRYDVFRTVFIHEKVKRPVQVVLKKRQFHIEEIDLTHLTGSEQTAKINEYKEQ DKIRGFDLTRDIPMRAAIFKKAEESFEWVWSYHHIILDGWCFGIVVQDLFKVYNALREQ KPYSLPPVKPYKDYIKWLEKQDKQASLHYWREYLEDFEGQTTFAEQRKKQKDGYEPKEL LFSLPEAETKAFTELAKSQHTTLSTALQAVWSVLISRYQQSGDLAFGTVVSGRPAEIKG VEHMVGLFINVVPRRVKL" aSModule 1787..5554 /complete /domains="nrpspksdomains_ctg3_2_Condensation_DCL.1" /domains="nrpspksdomains_ctg3_2_AMP-binding.1" /domains="nrpspksdomains_ctg3_2_PCP.1" /domains="nrpspksdomains_ctg3_2_Thioesterase.1" /final_module /locus_tags="ctg3_2" /monomer_pairings="Leu -> Leu" /tool="antismash" /type="nrps" CDS_motif 1796..1837 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg3_2_0001" /evalue="3.00E-05" /label="C1_DCL_004-017" /locus_tag="ctg3_2" /protein_end="26" /protein_start="12" /score="15.8" /tool="antismash" /translation="YYLSPMQEGMLFHA" CDS_motif 1859..1975 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg3_2_0002" /evalue="2.50E-12" /label="C2_DCL_024-062" /locus_tag="ctg3_2" /protein_end="72" /protein_start="33" /score="39.1" /tool="antismash" /translation="FYLEQITMKVKGSLNIKCLEESMNVIMDRYDVFRTVFIH" CDS_motif 2192..2257 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg3_2_0003" /evalue="1.70E-11" /label="C3_DCL_135-156" /locus_tag="ctg3_2" /protein_end="166" /protein_start="144" /score="36.5" /tool="antismash" /translation="YHHIILDGWCFGIVVQDLFKVY" CDS_motif 2303..2341 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg3_2_0004" /evalue="5.50E-04" /label="C4_DCL_171-183" /locus_tag="ctg3_2" /protein_end="194" /protein_start="181" /score="12.4" /tool="antismash" /translation="PYKDYIKWLEKQD" CDS_motif 2579..2674 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg3_2_0005" /evalue="1.30E-18" /label="C5_DCL_263-294" /locus_tag="ctg3_2" /protein_end="305" /protein_start="273" /score="59.4" /tool="antismash" /translation="DLAFGTVVSGRPAEIKGVEHMVGLFINVVPRR" CDS_motif 2723..2836 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg3_2_0006" /evalue="1.00E-17" /label="C67_DCL_14fromHMM" /locus_tag="ctg3_2" /protein_end="359" /protein_start="321" /score="56.6" /tool="antismash" /translation="QEQSLQSEPHQYVPLYDIQSQADQPKLIDHIIVFENYP" aSDomain 3167..4360 /aSDomain="AMP-binding" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ctg3_2_AMP-binding.1" /evalue="6.00E-113" /label="ctg3_2_AMP-binding.1" /locus_tag="ctg3_2" /protein_end="867" /protein_start="469" /score="369.3" /specificity="substrate consensus: Leu" /tool="antismash" /translation="FKEAVNVNPDAPALTYSGQTLSYRELDEEANRLARRLQKQGAGKG SVVALYTKRSLELVIGILGVLKAGAAYLPVDPKLPEDRISYMLADSAAACLLTHQEMKE QAAELPYTGTTLFIDDQTRFEEQASDPANAIDPNDPAYIMYTSGTTGKPKGNMTTHANI QGLVKHVDYMAFSEKDTFLSVSNYAFDAFTFDFYASMLNAARLIIADEHTLLDTERLTD LILQENVNVMFATTALFNLLTDAGEDWMKGLRCILFGGERASVPHVRKALRVMGPGKLI NCYGPTEGTVFATAHVVHDLPDSISSLPIGKPISNASVYILNEQSQLQPFGAIGELCIS GMGVSKGYVNRADLTKEKFIKNPFKPGETLYRTGDLARWLPDGTIEYVGRIDDQVKIR" CDS_motif 3353..3394 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg3_2_0007" /evalue="2.60E-05" /label="NRPS-A_a2" /locus_tag="ctg3_2" /protein_end="545" /protein_start="531" /score="17.4" /tool="antismash" /translation="LGVLKAGAAYLPVD" CDS_motif 3587..3646 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg3_2_0008" /evalue="1.40E-08" /label="NRPS-A_a3" /locus_tag="ctg3_2" /protein_end="629" /protein_start="609" /score="26.9" /tool="antismash" /translation="AYIMYTSGTTGKPKGNMTTH" CDS_motif 4154..4243 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg3_2_0009" /evalue="5.50E-13" /label="NRPS-A_a6" /locus_tag="ctg3_2" /protein_end="828" /protein_start="798" /score="41.1" /tool="antismash" /translation="PFGAIGELCISGMGVSKGYVNRADLTKEKF" CDS_motif 4325..4390 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg3_2_0010" /evalue="5.40E-12" /label="NRPS-A_a8" /locus_tag="ctg3_2" /protein_end="877" /protein_start="855" /score="37.6" /tool="antismash" /translation="YVGRIDDQVKIRGHRIELEEIE" aSDomain 4679..4885 /aSDomain="PCP" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ctg3_2_PCP.1" /evalue="1.50E-25" /label="ctg3_2_PCP.1" /locus_tag="ctg3_2" /protein_end="1042" /protein_start="973" /score="81.1" /tool="antismash" /translation="EETIAQIWSEVLGRKQIGIHDDFFALGGHSLKAMTAASRIKKELG IDLPVKLLFEAPTIAGISAYVKNG" aSDomain 4940..5554 /aSDomain="Thioesterase" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ctg3_2_Thioesterase.1" /evalue="8.10E-37" /label="ctg3_2_Thioesterase.1" /locus_tag="ctg3_2" /protein_end="1265" /protein_start="1060" /score="119.7" /tool="antismash" /translation="IFAFPPVLGYGLMYQNLSSRLPSYKLCAFDFIEEEDRLDRYADLI QKLQPEGPLTLFGYSAGCSLAFEAAKKLEEQGRIVQRIIMVDSYKKRGVSDLDGRTVES DVEALMNVNRDNEALNSEAVKQGLKQKTHAFYSYYVNLISTGQVKADIDLLTSGADFDM PEWLASWEEATTGAYRMKRGFGSHAEMLQGETLDRNAEILLE" CDS_motif 5084..5158 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg3_2_0011" /evalue="6.30E-10" /label="NRPS-te1" /locus_tag="ctg3_2" /protein_end="1133" /protein_start="1108" /score="31.5" /tool="antismash" /translation="QPEGPLTLFGYSAGCSLAFEAAKKL" CDS 5616..6344 /NRPS_PKS="Domain: Thioesterase (14-231). E-value: 3.7e-55. Score: 179.7. Matches aSDomain: nrpspksdomains_ctg3_3_Thioesterase.1" /gene_functions="biosynthetic-additional (rule-based-clusters) Abhydrolase_6" /gene_functions="biosynthetic-additional (rule-based-clusters) PF00561" /gene_functions="biosynthetic-additional (smcogs) SMCOG1004:thioesterase (Score: 213; E-value: 5.8e-65)" /gene_kind="biosynthetic-additional" /locus_tag="ctg3_3" /sec_met_domain="Abhydrolase_6 (E-value: 5.7e-15, bitscore: 50.3, seeds: 455, tool: rule-based-clusters)" /sec_met_domain="PF00561 (E-value: 2.4e-06, bitscore: 21.1, seeds: 48, tool: rule-based-clusters)" /transl_table=11 /translation="MSQLFKSFDASEKTQLICFPFAGGYSASFRPLHAFLQGECEMLAA EPPGHGTNQTSAIEDLEELTDLYKQELNLRPDRPFVLFGHSMGGMITFRLAQKLEREGI FPQAVIISAIQPPHIQRKKVSHLPDDQFLDHIIQLGGMPAELVENKEVMSFFLPSFRSD YRALEQFELYDLAQIQSPVHVFNGLDDKKCIRDAEGWKKWAKDITFHQFDGGHMFLLSQ TEEVAERIFAILNQHPIIQP" aSDomain 5658..6308 /aSDomain="Thioesterase" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ctg3_3_Thioesterase.1" /evalue="3.70E-55" /label="ctg3_3_Thioesterase.1" /locus_tag="ctg3_3" /protein_end="231" /protein_start="14" /score="179.7" /tool="antismash" /translation="QLICFPFAGGYSASFRPLHAFLQGECEMLAAEPPGHGTNQTSAIE DLEELTDLYKQELNLRPDRPFVLFGHSMGGMITFRLAQKLEREGIFPQAVIISAIQPPH IQRKKVSHLPDDQFLDHIIQLGGMPAELVENKEVMSFFLPSFRSDYRALEQFELYDLAQ IQSPVHVFNGLDDKKCIRDAEGWKKWAKDITFHQFDGGHMFLLSQTEEVAERIF" CDS_motif 5841..5912 /aSTool="nrps_pks_domains" /database="abmotifs" /detection="hmmscan" /domain_id="nrpspksmotif_ctg3_3_0001" /evalue="1.90E-08" /label="NRPS-te1" /locus_tag="ctg3_3" /protein_end="99" /protein_start="75" /score="26.7" /tool="antismash" /translation="PDRPFVLFGHSMGGMITFRLAQKL" CDS 6446..7672 /gene_functions="transport (smcogs) SMCOG1137:Major facilitator superfamily MFS 1 (Score: 340.8; E-value: 1.4e-103)" /gene_kind="transport" /locus_tag="ctg3_4" /transl_table=11 /translation="MRTSPRMKWFVLLFTFVFAIGMNSFRNSFQFFMLPMADAFHADRS LISVSVSIFMITTGIVQFFVGFFIDRFSVRKIMALGAVCISASFLVLPYSPNVHVFSAI YGVLGGIGYSCAVGVTTQYFISRWFDTHKGLALAILTNANSAGLLLLSPIWAAAPYHAG WQSTYTILGIVMAAVLLPLLVFGMKHPPHAQAETVKKSYDWRGFWNVMKQSRLIHILYF GVFTCGFTMGIIDAHLVPILKDAHVSHVNGMMAAFGAFIIIGGLLAGWLSDLLGSRSVM LSILFFIRLLSLICLLIPILGIHQSDLWYFGFILLFGLSYTGVIPLTAASISESYQTGL IGSLLGINFFIHQVAGALSVYAGGLFFDMTHGYLLIVAVCIVFVGLSAVIELVPFLDKQ KAKETHHSI" CDS complement(7687..8244) /locus_tag="ctg3_5" /transl_table=11 /translation="MIQYASESINLPGEITFKDVREIFFYQICKMSCFYFLLFCTIFAA VNFINGWPRIVYGSDALNLFMNSMLIIVMSVLFTLLLLLLLYVKFSRAYKKNERMKSKR TYTLNQEGIRICSKKYDLIFNWNEITAVFEYKNIFRINTSSSQYIAIPKHFFHSEEEMN RFKGIILKNTETKKLKFKKDQH" CDS complement(8298..9215) /gene_functions="transport (smcogs) SMCOG1166:transporter, EamA family (Score: 148.2; E-value: 5.3e-45)" /gene_kind="transport" /locus_tag="ctg3_6" /transl_table=11 /translation="MVKHQQAPAYIAAILYSFIIGLSFLFVKIALQTAEPFDILAHRST VPILFGWVKLSIRVKDVIAILPLALLYPALFFSFQAFGLVYSSSSEAGIIQAAIPIFTM VFAAYVLKERPTWTQKGFTVLSVAGVMFIFVMKGVDVESASLKGSLLILLSALSSAMYN TAARKMTQRFKLTELTYIMSAIGFVVFNAIALVRHGAAGTVGTYFLPFREPGFVLAIVY LGVLSSLVTSFLSNYTLSRIEAFKMSAFNQVSTIVTMIAGVVILNESLAWYHLAGAVCI MIGVVGSNINLEKKTKRPGMPAKK" CDS 9339..10673 /NRPS_PKS="Domain: Aminotran_1_2 (96-438). E-value: 6e-23. Score: 73.3. Matches aSDomain: nrpspksdomains_ctg3_7_Aminotran_1_2.1" /gene_functions="biosynthetic-additional (rule-based-clusters) Aminotran_1_2" /gene_functions="biosynthetic-additional (smcogs) SMCOG1019:aminotransferase (Score: 261.4; E-value: 2.3e-79)" /gene_kind="biosynthetic-additional" /locus_tag="ctg3_7" /sec_met_domain="Aminotran_1_2 (E-value: 2.4e-22, bitscore: 73.3, seeds: 48, tool: rule-based-clusters)" /transl_table=11 /translation="MEKYMSLVTRIEEMMQSTAYQEGDRLPSIRQLSARYQVSKSTVIR ALQELEKRHLIYSVPKSGYYIVKKTGKSKSGQPGPIDFATSAPDPDVFPYLDFQHCINK AIDTYKNDLFIYGTPKGLPSLICVLRKLLATQQVFADERHIFITSGVQQALSLLCAMPF PNGKEKIAIEQPGYHLMVEQLETLGIPAIGVKRTEEGLDIAEVERLFQTESIKFFYTMP RFHNPLGCSLSERDKQELVRLAEAYDVYLVEDDYLGDLEENKKADPLYAYDLSSHVIYL KSFSKMIFPGLRVGAAVLPEALTDTFYAYKKLNDIDCSMISQAALEIYLKSGMYGRHKE KIRDSYKERSLRLHQAIRTHRQLGSGRFTFSSGQAPCVHTHLVLPQDLPASRVIHRLKK QGVLLEAIDRHYLSDYPKENLLKINISNVKTEDIERGVNLLMSHL" aSDomain 9627..10652 /aSDomain="Aminotran_1_2" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ctg3_7_Aminotran_1_2.1" /evalue="6.00E-23" /label="ctg3_7_Aminotran_1_2.1" /locus_tag="ctg3_7" /protein_end="438" /protein_start="96" /score="73.3" /tool="antismash" /translation="DFQHCINKAIDTYKNDLFIYGTPKGLPSLICVLRKLLATQQVFAD ERHIFITSGVQQALSLLCAMPFPNGKEKIAIEQPGYHLMVEQLETLGIPAIGVKRTEEG LDIAEVERLFQTESIKFFYTMPRFHNPLGCSLSERDKQELVRLAEAYDVYLVEDDYLGD LEENKKADPLYAYDLSSHVIYLKSFSKMIFPGLRVGAAVLPEALTDTFYAYKKLNDIDC SMISQAALEIYLKSGMYGRHKEKIRDSYKERSLRLHQAIRTHRQLGSGRFTFSSGQAPC VHTHLVLPQDLPASRVIHRLKKQGVLLEAIDRHYLSDYPKENLLKINISNVKTEDIERG VN" CDS complement(10668..11342) /NRPS_PKS="Domain: ACPS (103-166). E-value: 6e-20. Score: 63.4. Matches aSDomain: nrpspksdomains_ctg3_8_ACPS.1" /gene_functions="biosynthetic-additional (smcogs) SMCOG1012:4'-phosphopantetheinyl transferase (Score: 188.7; E-value: 1.5e-57)" /gene_kind="biosynthetic-additional" /locus_tag="ctg3_8" /transl_table=11 /translation="MKIYGIYMDRPLSQEENERFMTFISPEKREKCRRFYHKEDAHRTL LGDVLVRSVISRQYQLDKSDIRFSTQEYGKPCIPDLPDAHFNISHSGRWVIGAFDSQPI GIDIEKTKPISLEIAKRFFSKTEYSDLLAKDKDEQTDYFYHLWSMKESFIKQEGKGLSL PLDSFSVRLHQDGQVSIELPDSHSPCYIKTYEVDPGYKMAVCAAHPDFPEDITMVSYEE LL" aSDomain complement(10845..11033) /aSDomain="ACPS" /aSTool="nrps_pks_domains" /database="nrpspksdomains.hmm" /detection="hmmscan" /domain_id="nrpspksdomains_ctg3_8_ACPS.1" /evalue="6.00E-20" /label="ctg3_8_ACPS.1" /locus_tag="ctg3_8" /protein_end="166" /protein_start="103" /score="63.4" /tool="antismash" /translation="IGIDIEKTKPISLEIAKRFFSKTEYSDLLAKDKDEQTDYFYHLWS MKESFIKQEGKGLSLPLD" CDS complement(11447..12094) /locus_tag="ctg3_9" /transl_table=11 /translation="MKQELVLRWTFYFAGLIILAFGVSLTIEGKALGISPWDAFHYSLF QHFGLTVGQWSIIIGALIVGFTSLFTRAWPKIGALLNMVLIGVFIDFFNFILPAPSTYT GSIIVFSLGVVLIGYGVGVYVSAGLGAGPRDSLMMLITEKTGWNVQWVRNGMELTILFA AWGMGGPIGFGTILTAILTGLILRFSLPQSIQLLNYAVARRTAAVKASPPVH" CDS complement(12415..13158) /gene_functions="transport (smcogs) SMCOG1000:ABC transporter ATP-binding protein (Score: 222.5; E-value: 1e-67)" /gene_kind="transport" /locus_tag="ctg3_10" /transl_table=11 /translation="MLTVKGLNKSFGENEILKKIDMKIEKGKVIAILGPSGSGKTTLLR CLNALEIPNRGELAFDDFSIDFSKKVKQADILKLRRKSGMVFQAYHLFPHRTALENVME GPVQVQKRNKEEVRKEAIQLLDKVGLKDKMDLYPFQLSGGQQQRVGIARALAIQPELML FDEPTSALDPELVGEVLKVIKDLANEGWTMVVVTHEIKFAQEVADEVIFIDGGVIVEQG PPEQIFSAPKEERTQRFLNRILNPL" CDS complement(13172..13876) /gene_functions="transport (smcogs) SMCOG1096:polar amino acid ABC transporter, inner membrane (Score: 244.4; E-value: 1.7e-74)" /gene_kind="transport" /locus_tag="ctg3_11" /transl_table=11 /translation="MFLNNLPALTLGTAIPWDLVQQSFWPILSGGIYYTIPLTILSFIF GMILALITALARMSKVRPLRWVFSVYVSAIRGTPLLVQLFIIFYLFPAFNVTLDPFPSA VIAFSLNVGAYASEIIRASILSVPKGQWEAGYTIGMTHQKTLFRVILPQAFRVSIPPLS NTFISLIKDTSLASQILVAELFRKAQEIGARNLDQILVIYIEAAFIYWIICFLLSLVQH VIERRLDRYVAK" CDS complement(13863..14669) /gene_functions="biosynthetic-additional (smcogs) SMCOG1091:glutamine-binding lipoprotein glnH (Score: 234.7; E-value: 1.6e-71)" /gene_kind="biosynthetic-additional" /locus_tag="ctg3_12" /transl_table=11 /translation="MKKALLALFMVVSIAALAACGAGNDNQSKDNAKDGDLWASIKKKG VLTVGTEGTYEPFTYHDKDTDKLTGYDVEVITEVAKRLGLKVDFKETQWDSMFAGLNSK RFDVVANQVGKTDRENQYDFSDKYTTSRAVVVTKKDNNDIKSEADVKGKTSAQSLTSNY NKLATNAGAKVEGVEGMAQALQMIQQGRVDMTYNDKLAVLNYLKTSGNKNVKIAFETGD PQSTYFTFRKGSGEVVDQVNKALKEMKEDGTLSKISKKWFGEDVSK" CDS complement(14785..15657) /gene_functions="regulatory (smcogs) SMCOG1014:LysR family transcriptional regulator (Score: 247.5; E-value: 2.8e-75)" /gene_kind="regulatory" /locus_tag="ctg3_13" /transl_table=11 /translation="MDIRQLRYFITIAQEQKITSAAKKLHMAQPPLSRQLKQLEDELGV VLFDRNKKKQMTLTYEGAVFLKRAKEILHRFEDAVIEVQELKEEVAGTLAVGSTIYCAA LMLEKVTQIKERYPHLTFNIWENEPATLLELLESRQIDAAVTTTLIKSDTVQFKQLDDI PCVLVLSDEAGYPCGDTIKMEDIPSFPLILLRPVNGKGVYNQVMNEFHRLNLEPRIVCE CHDSATLLSLVSSGFGASILPVTMIPVHMRNHVRTVHIENNPFIMTPAVMWRTDSYLPK PAQQFLDLF" CDS 15747..16361 /gene_functions="biosynthetic-additional (rule-based-clusters) Flavoprotein" /gene_kind="biosynthetic-additional" /locus_tag="ctg3_14" /sec_met_domain="Flavoprotein (E-value: 1.7e-32, bitscore: 105.9, seeds: 143, tool: rule-based-clusters)" /transl_table=11 /translation="MKAEFKRKGGGKVKLVVGMTGATGAIFGVRLLQWLKAAGVETHLV VSPWANVTIKHETGYTLQEVEQLATYTYSHKDQAAAISSGSFDTDGMIVAPCSMKSLAS IRTGMADNLLTRAADVMLKERKKLVLLTRETPLNQIHLENMLALTKMGTIILPPMPAFY NQPRSLEEMVDHIVFRTLDQFGIRLPEAKRWNGIEKQKGGA" CDS 16364..17785 /locus_tag="ctg3_15" /transl_table=11 /translation="MAYQDFREFLAALKKEGQLLTVNEEVKPEPDLGAAARAASNLGDK SPALLFNNIYGYHNARIAMNVIGSWPNHAMMLGMPKDTPVKEQFFEFAKRYDQFPMPVK REETAPFHENEITEDINLFDILPLFRINQGDGGYYLDKACVISRDLEDPDNFGKQNVGI YRMQVKGKDRLGIQPVPQHDIAIHLRQAEERGINLPVTIALGCEPVITTAASTPLLYDQ SEYEMAGAIQGEPYRIVKSKLSDLDVPWGAEVVLEGEIIAGEREYEGPFGEFTGHYSGG RSMPIIKIKRVYHRNNPIFEHLYLGMPWTECDYMIGINTCVPLYQQLKEAYPNEIVAVN AMYTHGLIAIVSTKTRYGGFAKAVGMRALTTPHGLGYCKMVIVVDEDVDPFNLPQVMWA LSTKMHPKHDAVIIPDLSVLPLDPGSNPSGITHKMILDATTPVAPETRGHYSQPLDSPL TTKEWEQKLMDLMNK" CDS 17802..18029 /locus_tag="ctg3_16" /transl_table=11 /translation="MHTCPRCDSKKGEVMSKSPVEGAWEVYQCQTCFFTWRSCEPESIT NPEKYNPAFKIDPKETETAIEVPAVPERKA" CDS 18026..18490 /locus_tag="ctg3_17" /transl_table=11 /translation="MIRVNSLSDRLFELLDGRCLSEKQHEAFVLQTVSEDGWPHAAMIS AGEIIALSRTDIRIALWKNTMTSANILRTGKAQFTAWWKGAAYYVKLECAPLPPLKDAE YDRDRFSCRIVSVKEDVAKYADLTSGVRIQLHSAEEVLSRWEKTLEDLKR" CDS 18556..19401 /gene_functions="biosynthetic-additional (rule-based-clusters) PF00561" /gene_functions="biosynthetic-additional (rule-based-clusters) Abhydrolase_6" /gene_functions="biosynthetic-additional (smcogs) SMCOG1036:alpha/beta hydrolase fold protein (Score: 70.6; E-value: 2.9e-21)" /gene_kind="biosynthetic-additional" /locus_tag="ctg3_18" /sec_met_domain="PF00561 (E-value: 1.1e-15, bitscore: 51.7, seeds: 48, tool: rule-based-clusters)" /sec_met_domain="Abhydrolase_6 (E-value: 1.3e-09, bitscore: 32.8, seeds: 455, tool: rule-based-clusters)" /transl_table=11 /translation="MERAGICHSDGFDLAYRIEGEGAPILVIGSAVYYPRLFSSDIKQK YQWVFVDHRGFAKLKRGLRAEDSRLDAVLADIERMRTFLQFEDIIILGHSGHAFMALEY ARTYPEHVRKVALFNTAPDNSEERQRKSESFFMETASLERKKRFEKDIVNLPQDIEKDP ERRFVHMCIRAEAKSFYQERPHAAALWDGVFTNMPIIDELWGNTFARIDLIQRLADVRM PVYIGLGRYDYLVAPVALWDAVDNLYPHVDKVIFERSGHQPMLEEPEAFSQSFSKWLDQ " CDS complement(19442..20920) /gene_functions="transport (smcogs) SMCOG1202:major facilitator transporter (Score: 53.3; E-value: 2.8e-16)" /gene_kind="transport" /locus_tag="ctg3_19" /transl_table=11 /translation="MASIDNESIIKSVPQKGFFGHPRGLFTLFFTEFWERFSYYGMRAI LLYYLYTETVNGGLGFDKGTAVAIMSIYGSLVYMSTIIGGWLADRVFGTANTVFYGGIF IMFGHIALAYPGSSIAFYISMVLIIVGTGLLKPNVSSVVGDLYTKEDPRRDSGFSIFYM GINLGGLLAPLIVGTLGQKYNYHLGFGAAAVGMLLGLIVFALTRKKNLGLAGSNVPNPL SKKSAIGTGIGVIIVAIAVIISVQTGVLTINRFIDLVSILGILIPVIYFIIMFTSKKAD KTEKSRLAAYVPLFIGAVMFWAIQEQGATILAVYADERIRLSLGGFELQSSWFQSLNPL FVVIFAPIFAWLWMKLGKRQPSTPVKFSIGIILAGLSFIIMVFPAMQGKEALVSPLWLV LSFLLVVLGELCLSPVGLSVTTKLAPAAFSAQTMSMWFLTNAAAQAINAQVAGLFDKIP ETMYFGTIGLISIVLGGILLLLSPVIKRAMKGVL" CDS 21201..22955 /locus_tag="ctg3_20" /transl_table=11 /translation="MAEFILNAADFGVPGDGKTDSTERINQCLSTAVSKGYHTVWFPKG TYLIDATLGGDLNQRFRNAGIIVPGNLEIMMDPECIMKVIPNSSWGYSAFYVGKQENIT ISGGQIIGERDEHTYASAGIRSTHEWGFGICIEGCSNVVIDDVKISDFTGDGIIVSPRG LKTNQDYRTSEQIIIRRCEVRRSRRNNISITGCDMVTVEECLIEDAGTGNGTAPKFGID IEGYGEGDVDYEEPINVSIRNNHFVGNVSSSVTNFNGYGILIEGNHSDNTISYGYGTQT VIKGNILRRPEDAAAAPRVGITGLGVSQGKETSDAVIAGNLITGFSTGIDVRGKSVLVT NNKISNFENTGILVYQSSDVKVDGNQIQNGLSETRRSIGLRAVLSDDIAFLNNCLIQVV DGVSVSGGNMIIKDNLLRKFSRGIWIAQGNAVIEGNTLNPGAFEAVPESYSVSVTNNAG AIIKNNTFKEFKNYPIYCSTSAKTSIIGNHLERSPLLVTIYISAGVHEIFDNTISVNRT AGNPIVIYLNGSAGSIISGNTINNLSAGTATAIQTNTSTNSKIIGNRIFKGTINKHSSD AIDGNIIV" CDS complement(22970..23191) /locus_tag="ctg3_21" /transl_table=11 /translation="MKILGVTGVILICLLAISVLMDMLQGFSLTKAIYNNMSSFKMTTF AEWVVLLFFVLVLVREMYVIYKSKKKNP" CDS 23317..24951 /locus_tag="ctg3_22" /transl_table=11 /translation="MPLFSKRKNNTSSKDKRNTEEKNQEQKQEKERPVLISPSMAKNIA ETKKEVGSSSDVIIREIKIGEQDHVHLAVIYIAGLVDNNTIHESLIDPLVQDESIQNTH AIQQILEKTLPLGGVKAEKSWDKLFSELMLGNALIFADGHDEALICSTQGGEQRSIQEP STQVSFRGPRQGFTESLQTNISMIRRYIKNPNLWVEKMKKGSVTNTDIALMYIQGICDE KVLKEVKQRLEKIDIDSILESGYIEQLIEDETFTTFPTMYHTERPDVVAGNLLEGRFAI IVDGTPFVLIAPALFVQFFQSVEDYYSRFDIATSIRILRVLVFFISLVAPAVYVAATTF HQEMIPTQLLVVIAAQREIVPFPAVVEALTMEVAFEILREAGVRLPRVVGSAVSIVGAL VIGQAAVQAGIVSPAMVIFVALTAIASFATPAFAMAISARLIRFIFIIASAVMGFYGLI LGIIMMFVHLCSLRSFGVPYMSPLAPFSSQGVKDALFRVPWWADEKRPESVSKEDKVRQ GKDQRPEPAASRGMVNKDLEEGDQNGT" ORIGIN 1 ggcaaacggc aaagtggacc gtaaagcctt gcctgagccg gacatcgaag cgggaagcgg 61 agaatacaaa gcgcctacga ccgacatgga agagctgctt gccggcatct ggcaggacgt 121 gcttggaatg tctgaagtcg gtgtcaccga caatttcttc tcgcttggcg gagattccat 181 caaaggaatt caaatggcga gccgcttgaa ccagcacggc tggaagctgg aaatgaaaga 241 tctcttccag cacccgacga tcgaagagct cacccagtac gtagagcgtg ccgaaggcaa 301 acaggcagac caaggcccgg tagagggcga agtcatcctg acgccgatcc agcgctggtt 361 ctttgaaaag aacttcacga acaagcacca ctggaaccaa tcggtgatgc ttcacgccgc 421 gaagggcttt gaccctgaac gggtggagaa aacattgcag gcgctgatcg agcatcatga 481 cgcgctccgc atggtctatc gtgaggaaaa cggggacatc gttcaggcgt atcaaccgat 541 cagtgagagc aaggtcagct tcgaaatcgt ggatctgtac ggctccgatg aagagatgct 601 gagaagccag attaaaattc tcgcgaacaa gctgcagagc agtctcgatc tgcaaaacgg 661 gccgcttcta aaggcggagc aatatcgcac agaagccggg gatcacctgc tcattgctgt 721 acaccatctg gtggtcgacg gtgtgtcatg gcggattttg cttgaagatt ttgcttcagg 781 ctacatgcag gctgagaaag aagagagcct tgtcttcccg caaaaaacaa actccttcaa 841 ggactgggcg gaagaactgg cggcattcag ccaatcagcg catcttttac agcaggctga 901 atactggtcg caaattgccg ctgaacaggt ttctccttta ccgaaggatt gtaaaacaga 961 gcagcggatc gtcaaggata catcatctgt cctatgtgaa ttaacggaag aagacactaa 1021 gcatctttta acagatgttc atcagccata tggaactgaa atcaacgata ttcttctcag 1081 cgcgctcggt ttgacaatga aagaatggac aaagggggcc aaaatcggca ttaaccttga 1141 gggacacggc cgggaggaca ttatcccgaa tgtgaatatc tccagaacgg tcggctggtt 1201 tacggcacaa taccctgttg tgctcgacat atctgacgca gatgcctcgg ctgtgatcaa 1261 aacagtcaaa gaaaacctgc gccgcattcc ggacaaaggt gttggctacg gcattcttcg 1321 ttatttcaca gaaacagcgg aaacaaaggg cttcacaccg gagatcagct tcaactattt 1381 gggccaattc gacagtgaag tcaaaaccga tttctttgaa ccgtccgctt tcgatatggg 1441 gcgccaagta agcggagaat cagaggcgct gtacgcttta agcttcagcg gcatgatcag 1501 aaacggccgg tttgtgcttt cctgctccta caatgagaag gagtttgaaa gagctacagt 1561 cgaggagcaa atggaacggt ttaaagaaaa cctcctgatg ctaatccgcc attgcacgga 1621 aaaagaagac aaggaattca caccaagcga cttcagcgcc gaagaccttg aaatggacga 1681 gatgggagat atctttgaca tgcttgagga gaatttaaaa taaaacgcaa gggaattaca 1741 gaaggcggga gcgaaacata tgagtcaatt tagcaaggat caggttcaag atatgtatta 1801 cctatcgccg atgcaggaag ggatgctttt tcatgccatc ctgaatcccg gccaaagctt 1861 ttaccttgaa caaatcacga tgaaagtaaa aggcagcttg aatatcaaat gtcttgaaga 1921 aagcatgaat gtgatcatgg accggtacga tgtatttcgt accgtgttca ttcacgaaaa 1981 agtaaaaaga cctgtccaag tcgtattgaa aaaacggcag ttccatatag aagaaatcga 2041 tctgacacac ttaacgggca gcgagcaaac agccaaaatc aatgagtaca aagaacagga 2101 taagatcagg ggttttgatt tgacgcggga tattccgatg cgggcagcca ttttcaaaaa 2161 agctgaagaa agctttgaat gggtgtggag ctaccaccac attattttgg acggatggtg 2221 cttcggcatc gtcgtacagg atctatttaa ggtatacaat gctctgcgcg aacaaaagcc 2281 gtacagcctg ccccccgtca aaccgtataa agactacatc aagtggcttg aaaagcagga 2341 taaacaagca tcactgcatt actggcgcga gtatttagag gactttgaag gacaaacgac 2401 gtttgcggag caaagaaaga aacaaaagga cggctatgag ccgaaagagc tgctcttttc 2461 actgccggag gcggaaacaa aggcttttac tgagcttgca aaatcgcagc ataccacttt 2521 aagtacggcg ctgcaggcag tctggagcgt attgatcagc cgctatcagc agtctggcga 2581 tttggccttc ggtacagttg tttcagggcg tcccgcggaa atcaaaggcg ttgaacatat 2641 ggtcgggctg tttatcaacg ttgtcccgag acgtgtgaag ctgtctgagg gtatcacatt 2701 taacggcttg ctcaagcagc tgcaggagca atcgctgcag tctgagccgc accaatatgt 2761 gccgctttat gacatccaaa gccaggccga tcagccgaaa ctgattgacc acatcattgt 2821 ttttgagaac tatccgcttc aggatgcgaa aaatgaagaa agcagtgaaa acggctttga 2881 tatggtggat gttcatgttt ttgagaagtc gaattatgat ctcaacctga tggcttcccc 2941 gggagatgag atgctgatta agcttgctta taacgagaat gtgtttgatg aggcgtttat 3001 cctgcgcttg aaatctcagc ttctcacagc aattcagcag ctcatccaga atccggatca 3061 gcctgtcagc acgatcaacc tcgttgacga cagggagaga gaatttttgc taaccggctt 3121 aaacccgccg gctcaagctc atgaaacaaa gcctctgacg gattggttca aggaagcagt 3181 gaacgtcaat ccggatgcgc cggcgcttac gtattccggc cagaccctgt cttatcgcga 3241 attagatgag gaagcgaacc gccttgcacg ccggctgcaa aaacaaggtg cgggcaaagg 3301 ctctgttgta gcgctgtaca cgaagcgctc acttgaactg gtgattggca ttctcggtgt 3361 attaaaggcg ggagcagcct atctgccggt tgatccgaag ctgccagagg accgaatctc 3421 gtatatgctg gctgacagtg cggcagcctg tcttctgacg catcaggaga tgaaagaaca 3481 agcggctgag ctgccgtata caggcacaac gctcttcatc gatgatcaaa cacggtttga 3541 agaacaggca agcgatcctg caaatgcgat tgatcctaat gatccggcat atatcatgta 3601 cacgtccggc acaaccggaa agccaaaggg caatatgacc actcatgcca atattcaagg 3661 attggtcaag catgtagact acatggcatt ctctgagaaa gatacattct tatctgtttc 3721 caattacgcc tttgacgcat ttacctttga tttctatgct tctatgctga atgcggcacg 3781 gctcattatc gcagatgaac atacgctgct tgatacagaa cggctcacag atctgatcct 3841 gcaagagaat gtcaatgtca tgtttgcgac aaccgcacta tttaatcttc tcacggatgc 3901 gggagaggat tggatgaagg gactacgctg tatattattc ggcggagagc gcgcctcagt 3961 gcctcatgtc agaaaagcgc tgcgggtcat ggggccgggc aagctgatta actgctacgg 4021 gccgactgag ggaacagtgt ttgcgactgc tcacgtcgtg catgatctac cggattccat 4081 ctcctcattg ccgatcggaa agccgatcag caatgccagt gtttatattc tgaacgagca 4141 aagccagctc cagccattcg gggcgatcgg tgaactgtgc atcagcggaa tgggcgtgtc 4201 aaaaggatat gtaaatcgtg ctgacctcac gaaggaaaag tttattaaga acccgttcaa 4261 gccgggagaa acgctttacc gcacagggga tttagcgcgc tggctgccgg atggaacgat 4321 tgaatacgtc ggccgtattg acgaccaggt caaaatacgt ggacaccgga ttgagcttga 4381 agaaatcgaa aagcagctgc aggaataccc aggtgtgaaa gatgcggtcg ttgtggcgga 4441 ccgccctgag tctggcgatg catcaatcaa tgcctacctc gtgaaccgga cgcagctttc 4501 agctgaggac gtgaaggcgc acctgaaaaa acagcttcct gcttacatgg tgccgcaaac 4561 ctttaccttc ttggatgagc ttcctttaac gacgaacggg aaagtcaata aacggctgct 4621 cccaaaacct gatcaggatc agctggcgga agaatggatc ggaccgcgga acgagatgga 4681 agaaacaatc gcacaaatat ggtctgaggt tctcggcaga aagcaaattg gcattcatga 4741 cgatttcttt gcgctcggag ggcattcctt aaaggcaatg accgccgctt cccgcattaa 4801 gaaagagctt gggattgatc ttccagtaaa gcttttgttt gaagcgccga cgatcgccgg 4861 catttcagcg tatgtgaaaa acgggggtcc tgatggcatg caggatgtaa cgataatgaa 4921 tcaggatcag gagcagatca ttttcgcatt cccgccggtc ttgggctatg gccttatgta 4981 ccaaaatctg tccagccgct tgccgtcata caagctgtgc gcctttgatt ttattgagga 5041 ggaagaccgg cttgaccgct atgcggattt gatccagaag ctgcagccgg aagggccttt 5101 aacattgttt gggtattcag cgggatgcag cctggcgttt gaagctgcga aaaagcttga 5161 ggaacaaggc cgtattgttc agcggatcat catggtcgat tcctataaaa aacgaggtgt 5221 cagtgatctg gacggacgca cggttgaaag tgatgtcgaa gcgttgatga atgtcaatcg 5281 ggacaatgaa gcgctcaaca gcgaagccgt caaacaaggc ctcaagcaaa aaacacatgc 5341 cttttactca tactacgtca atctgatcag cacaggccag gtgaaagcag atattgatct 5401 gctgacttcc ggcgctgatt ttgacatgcc ggaatggctt gcatcatggg aagaagctac 5461 aacaggtgct taccgtatga aaagaggctt cggatcacac gcagaaatgc tgcagggaga 5521 aacgctagat aggaatgcgg agattttgct cgaatttctt aatacacaaa ccgtaacggt 5581 ttcataaatg aagtgatgaa aggaggagac agccaatgag ccaactcttc aaatcatttg 5641 atgcgtcgga aaaaacacag ctcatctgtt ttccgtttgc cggcggctat tcggcgtcgt 5701 ttcgccctct ccatgctttt ttgcaggggg agtgcgagat gctcgctgcc gagccgccgg 5761 gacacggcac gaatcaaacg tcagccattg aggatctcga agagctgacg gatttgtaca 5821 agcaagaact gaaccttcgc cctgatcggc cgtttgtgct gttcggacac agtatgggcg 5881 gaatgatcac cttcaggctg gcgcaaaagc ttgagcgtga aggcatcttt ccgcaggcgg 5941 ttatcatttc tgcaatccag ccgcctcata ttcagcggaa gaaagtgtcc cacctgcctg 6001 atgatcagtt tctcgatcat attatccaat taggcggaat gcccgcagag cttgttgaaa 6061 ataaggaggt catgtccttt ttcctgcctt ctttccgatc agattaccgg gctcttgaac 6121 aatttgagct ttacgatctg gcccagattc agtcgcctgt tcatgtcttt aacgggcttg 6181 atgataaaaa atgcatacga gatgcggaag gctggaagaa atgggcaaaa gacatcacat 6241 tccatcaatt tgacggcggg cacatgttcc tgctgtcaca aacggaagaa gtcgcagaac 6301 ggatttttgc gatcttgaat cagcatccga tcattcaacc gtgatcaaaa gcggacagct 6361 tcggctgttc cgcttttttt tgtgttgaat gccaattttt gcatggtata atagtcgaaa 6421 tactcaaata aaggcaggtt gaaacatgcg cacgtctccc aggatgaaat ggtttgtatt 6481 gctgtttacg tttgttttcg ccatcggaat gaactcattc agaaattcct ttcaattttt 6541 tatgctgcca atggcagacg ccttccatgc cgacaggtcg ctgatttcgg tttctgtcag 6601 catttttatg atcacaaccg gcatcgtcca gttttttgtc ggttttttta ttgaccgttt 6661 cagtgtcaga aaaattatgg cgcttggagc tgtctgcatc agcgcaagct ttttggtgct 6721 tccttattca ccgaatgttc atgtgttttc cgccatttac ggtgtgcttg gcggaatcgg 6781 ctattcctgc gcggtcggcg tgacgaccca gtacttcatc agccgttggt ttgacacaca 6841 caaaggcctg gcgcttgcta ttttgaccaa tgccaactct gcgggcctgc tgcttctctc 6901 gcccatttgg gctgcggctc cgtatcatgc tggctggcag agcacctata cgattttggg 6961 aatcgtcatg gcggctgttc tgctgccgct cctcgtcttt gggatgaagc acccgccaca 7021 tgcgcaagcg gaaactgtga aaaaatctta tgattggcgg gggttttgga acgtgatgaa 7081 gcaatcccgc ctcattcata tcctgtactt cggcgtgttt acttgcggat ttacaatggg 7141 aattattgat gctcacctcg tcccgatact taaggatgcg catgtctctc atgtcaacgg 7201 aatgatggcc gcgttcgggg cgtttatcat cattggcgga ttattggcag gctggctgtc 7261 cgatctcctc gggagcagaa gcgtcatgct atccatctta tttttcattc ggctgctcag 7321 cctgatttgc ctgctcattc ccattctcgg aattcatcaa agcgaccttt ggtacttcgg 7381 gtttatcctg ttattcgggc tcagttacac aggcgtgatc ccgctgaccg cggcgtcaat 7441 ttcggaaagc tatcaaacag gattgatcgg atcgctgtta ggcatcaatt tctttatcca 7501 tcaggttgcc ggagctctca gcgtgtatgc gggcggtttg ttttttgaca tgactcatgg 7561 ttatttgctg attgtcgctg tgtgcatcgt gtttgtgggt ttatcggctg taatagagct 7621 ggtgccgttt ttagataaac aaaaggcaaa agaaacccac cattcaatat aaaaggatca 7681 gcactgtcaa tgctgatcct ttttaaattt gagttttttt gtttcggtat ttttaaggat 7741 aatccccttg aatctgttca tctcctcttc ggaatgaaaa aaatgttttg ggatcgcaat 7801 atattggctg ctggatgtat tgatgcgaaa gatattctta tattcgaaaa cagctgtgat 7861 ttcattccaa ttgaaaatga ggtcatattt tttagaacat atacgaattc cttcttggtt 7921 cagagtatat gttcttttag atttcatccg ttcgttcttc ttgtatgctc tggaaaactt 7981 cacatataga agcaggagga gcagcagtgt aaacagaacg gacatcacga taatcaacat 8041 actgttcata aacaagttaa gcgcgtcact gccataaacg atacggggcc atccgttaat 8101 gaagttaact gcagcaaata tggtgcaaaa caacagaaag taaaagcatg acattttgca 8161 gatttgataa aaaaagattt ctcttacatc cttaaaagtg atttctcctg gaagattgat 8221 actttcacta gcatattgaa tcatacggta aacctacacc tctaaccatg tttttccttt 8281 tagtctagca taatttctca tttttttgca ggcataccag ggcgctttgt ttttttctcc 8341 agattgatat tgctccccac cacgccaatc ataatacaaa cagcgccggc aagatgatac 8401 caggccaggc tttcgttgag aatcacaact cctgcaatca tcgtcacaat ggtagatacc 8461 tgattaaaag cgctcatttt aaacgcctca attcgcgaca gcgtatagtt agacagaaat 8521 gaagtgacaa gtgaagacag cacgcccaaa tacacaatgg cgagaacgaa gccgggctcc 8581 cggaacggca gaaaataagt gccgactgtt cccgccgctc catgacgcac aagggcgatg 8641 gcgttgaaga cgacaaagcc gatggctgac atgatgtagg tgagctctgt cagcttgaac 8701 cgctgcgtca tttttctggc agcagtattg tacatcgctg aagacaaagc ggacaatagg 8761 atcagcaaag acccttttaa gctggctgat tccacgtcaa cgcctttcat cacaaaaata 8821 aacatgacgc cggcaacgga taaaaccgtg aacccctttt gcgtccacgt tgggcgttcc 8881 tttaaaacat aagcggcaaa gaccatcgtg aaaatcggaa tggctgcttg aataattccc 8941 gcttcagagg aggacgagta cacaaggccg aatgcctgaa agctgaaaaa taacgcggga 9001 tacagcaggg cgagcggcaa aatggcaatg acgtccttta cgcggattga tagctttacc 9061 cagccgaata agatcggtac agtggaccga tgcgccaaaa tatcaaacgg ctctgctgtt 9121 tgcagtgcga tttttacgaa tagaaaggat aaaccgataa tgaacgaata taaaatagcc 9181 gctatataag cgggggcttg ctgatgttta accataatgg gaagggctcc tttacctgaa 9241 ttgcagcgcc ggtcgctccc tttattgtat ggccgcggtc agaacggtac aatgagaaaa 9301 acaatgaact gtaccggtac aaaacagggg gagaaggcat ggagaaatat atgagtctag 9361 taacgaggat agaggagatg atgcaaagca ccgcctatca agaaggagac aggcttccat 9421 ctatccgtca gctgtccgcc cgctaccaag tcagcaaaag cacagtgatc cgcgcgctgc 9481 aggagctgga aaagcgccac cttatctatt ctgttccgaa aagcggctat tatattgtga 9541 aaaagacagg gaaatcaaaa agcgggcagc ctggccccat cgactttgcc acatctgcgc 9601 cggacccaga tgtgtttccg tatcttgatt ttcagcactg tatcaacaaa gcgattgata 9661 catacaaaaa cgatttgttt atttatggga cgccaaaggg gcttccatca ctcatctgcg 9721 tactccgaaa gctcttggcc actcaacagg tatttgcgga tgaacggcat attttcatta 9781 catcaggtgt ccagcaggcg ttatccttgc tttgtgccat gccgttccca aatgggaaag 9841 agaagatcgc cattgaacag ccgggctacc atttgatggt cgaacagctt gagacgcttg 9901 ggattcccgc tatcggggtg aaacgaacgg aagaagggct tgatatagcc gaggttgagc 9961 ggttatttca aacagaatcg attaaatttt tttatacgat gccgcgcttc cataacccgc 10021 ttgggtgctc attgtcagag cgtgataaac aggagcttgt gagactggca gaagcgtatg 10081 atgtctacct cgttgaggat gattacctcg gtgatctgga ggaaaataaa aaggcagatc 10141 cgctgtacgc atatgatctg tcctcacatg tcatctattt gaaaagcttc tcgaaaatga 10201 tattccccgg ccttcgcgtg ggggcggctg ttttgcccga agcgctgact gacacgttct 10261 atgcgtacaa aaagctgaac gacatcgact gttcgatgat ttctcaagcg gcattggaga 10321 tttacctgaa aagcggtatg tacggcaggc ataaggagaa aatcagagat tcttataaag 10381 agcggtcgct gaggctacat caagccattc gaactcacag gcagctggga agcggccgct 10441 ttacgttctc cagcgggcag gcaccctgcg tgcacaccca cctggtgctt cctcaggatc 10501 tgcccgcctc aagagtgatt catagactga aaaaacaagg ggttctcctt gaggcgatag 10561 accgtcatta tttatcagat tatccgaaag aaaatctatt aaaaatcaat atttccaatg 10621 tgaaaacgga agatattgag cgcggtgtca acctgttgat gagccatcta taaaagctct 10681 tcgtacgaga ccattgtgat atcctcgggg aaatcagggt gtgcggcgca tacagccatt 10741 ttgtagccgg gatcgacctc atacgttttg atatagcatg gggaatggct gtccggaagc 10801 tcaatggata cttgtccgtc ctgatgcagg cgcactgaaa aggaatcaag cggaagcgat 10861 aagcctttgc cttcctgttt gataaagctt tctttcattg accatagatg ataaaaatag 10921 tctgtctgct cgtccttgtc ttttgctaaa aggtcgctgt actctgtttt tgaaaagaag 10981 cgcttggcga tctcaaggct gatcggtttc gttttttcga tatctatgcc gatcggctgt 11041 gaatcaaacg caccaatgac ccagcggccg gagtgagaaa tgttgaaatg agcgtcggga 11101 agatcaggga tgcacggctt cccgtattcc tgcgtgctaa agcggatatc ggatttgtcc 11161 aactgatact gcctgcttat gactgagcga acgagcacat ctcccagcag ggtgcggtga 11221 gcatcttctt tatgataaaa tctccggcat ttctcccgtt tttcaggtga tatgaaagtc 11281 atgaaccgtt cattttcttc ctgtgaaagc gggcggtcca tataaattcc gtaaatcttc 11341 attctagatc ctccgtctgc aaaagattgt caaaaccatc ctatcatact tccacaagac 11401 tcatatagag gagaaaataa aaaaacaaag ccaaggcggc tttgttttag tgtacaggcg 11461 gagatgcttt cacagcggct gtccgccttg ccacagcata attcagcaac tggattgact 11521 ggggcaatga aaaacgcaaa ataagtccgg tgaggatggc agtcaaaatg gtgccaaaac 11581 cgatcggtcc gcccatgccc catgccgcaa acaaaatggt taattccatg ccgttccgca 11641 cccattgcac attccagccg gttttttctg taatcagcat catcagtgaa tcacgcggcc 11701 ccgcaccaag gcctgctgat acataaacac cgacgccgta accgatcagc accacgccta 11761 gagagaagac gatgatcgag cctgtgtagg tcgagggggc aggcagaatg aaattgaaaa 11821 aatctataaa tacaccaatg agcaccatat tcaggagggc cccaattttc ggccaagctc 11881 tcgtaaacaa tgacgtgaat ccgacgatga gcgctccaat aatgatggac cactggccga 11941 cggtaagccc gaagtgctga aacaggctgt aatgaaatgc atcccacgga ctaatgccga 12001 gtgcttttcc ttctatcgtc agggatacac caaaagccaa aatgatcaaa ccggcaaaat 12061 aaaatgtcca gcgcagaaca agttcttgct tcacgtgagg tcccttcttt cgtaaaaatc 12121 agtcgattgt cattgtagca catctgacag aagggcggaa taggcgaaag gggctcaaca 12181 aaaaaacagg gccgctacgg gcgccctgtt tcagcgtgtt ggcaaaccct tgcattcgtt 12241 gtcaggtctg tgcttcggta ctcacgaatt taacattcgc tgtgctccaa tgctcgccct 12301 tcctagactt caaaggtttt caatcacgct gaaaatcaca aaattctaaa acgaaaatcg 12361 ttttagaatt ttgtcaataa tctgaaacag ggcgctggcg ccctgttttt cttattacag 12421 cgggttcaaa atccggttca agaaccgctg tgtccgttct tcttttggtg cggagaaaat 12481 ttgctccggc ggtccttgct ccacgataac gccgccgtcg atgaagatga cttcatccgc 12541 aacttcctgc gcgaacttga tttcgtgggt cacgacgacc atggtccagc cttcattggc 12601 caagtccttg ataaccttca gcacctctcc gacaagctcg ggatcaagcg ctgaggtcgg 12661 ttcgtcaaac agcatgagct caggctgaat cgccagtgcg cgggcgatgc cgacgcgctg 12721 ctgctgtccg ccggaaagct ggaatggata taaatccatt ttgtccttca atccgacttt 12781 atcaagaagc tgaatcgctt cttttctgac ttcctctttg ttccgttttt gcacctgaac 12841 agggccctcc atcacgtttt cgagggctgt gcggtgcggg aacaggtgat acgcctgaaa 12901 caccattccg gattttcggc gaagctttag gatatccgcc tgtttcacct ttttggagaa 12961 atcgatggag aaatcatcaa atgcaagctc tccgcgattt gggatctcca gagcgttcag 13021 gcagcggagc agcgtcgttt tccctgaacc tgaaggccca agtatggcga tgacttttcc 13081 tttttcaatc ttcatatcta tcttttttaa aatttcattt tcaccgaatg atttgtttaa 13141 tcctttaacg gtaagcatac tcggaacctc cttatttggc cacgtagcgg tcaagacgcc 13201 gttcgatgac atgctggacg agtgagagca ggaagcagat aatccaataa ataaaggctg 13261 cttcaatata gatcactaaa atttgatcaa gattccgcgc gccgatttcc tgggcttttc 13321 tgaacagctc agcgaccaga atttgagagg cgagggatgt atctttaatc aggctgataa 13381 aggtattgga taatggcggg atcgacacac gaaacgcctg cggcaaaatg acgcggaaca 13441 gcgttttttg atgtgtcatg ccaattgtgt agccggcttc ccattgccct ttcggcacgg 13501 ataaaataga tgcccgaatg atttcagatg cataggcgcc gacgtttaat gaaaaggcga 13561 taactgcgct tggaaatgga tctaatgtga cgttaaaggc cgggaacaga tagaaaatga 13621 tgaacaattg aacgagaaga ggagtgccgc gtattgcgga tacgtatacg ctgaacaccc 13681 atctcaaagg tctcactttc gacattctgg caagcgccgt aatcagcgcc aggatcattc 13741 cgaatataaa ggaaagaatc gtaaggggaa tcgtatagta gattccccct gaaagtatcg 13801 gccagaatga ctgctgcacc agatcccacg ggatcgccgt gccaagcgtc aatgccggca 13861 gattatttag aaacatcttc gccgaaccat tttttagaaa ttttagaaag agtcccgtcc 13921 tctttcattt cttttaatgc tttgttgact tgatcaacaa cctcgccgct tcctttacgg 13981 aacgtgaaat atgttgactg aggatcacct gtttcaaacg cgattttcac gtttttattg 14041 ccagatgttt ttaagtagtt caatacggca agcttatcgt tgtatgtcat atcgacgcgg 14101 ccttgctgga tcatttgaag ggcctgcgcc atgccttcaa cgccttctac tttagcgccg 14161 gcatttgtag ctaatttgtt gtagttgctt gtcagtgatt gagctgacgt ttttcctttt 14221 acatctgctt cagacttaat atcgttgttg tcttttttcg ttacgacaac ggctcttgat 14281 gttgtgtatt tatctgagaa atcatattga ttttcacgat ctgtttttcc gacttggttg 14341 gcaacaacgt caaaccgttt ggaattcagg ccggcaaaca tactgtccca ttgtgtttcc 14401 ttaaagtcga ctttaagccc gaggcgtttt gcgacttctg tgataacttc gacatcatag 14461 ccagtcagtt tatcagtgtc tttgtcgtgg taagtgaacg gttcatatgt tccttccgtt 14521 ccgactgtga gcacaccttt tttcttaatt gaagcccaaa gatcgccatc tttggcatta 14581 tcttttgact gattgtcatt tcctgctccg caagctgcaa gagctgcaat acttacgacc 14641 atgaataaag ccaataatgc ttttttcatc ttattcccca cttttctggt tgattttatt 14701 gaaataaaaa aatagcttac aaatctaaag gataactttt ttttagtatg agtcaagtaa 14761 ttggttttca taaggcaaaa tcttttaaaa taaatccaaa aattgctgtg ccggtttagg 14821 caaataactg tccgttctcc acatgacagc cggtgtcata atgaagggat tattttcgat 14881 atgaacggtg cgaacgtgat ttctcatatg aacgggaatc attgtgacgg gcaaaataga 14941 cgcgccgaat ccggatgaca cgaggctgag caaagttgca gagtcgtggc attcacaaac 15001 aatgcgcggc tccaggttca aacgatgaaa ttcattcatg acctgattat agacgccttt 15061 tccgttgaca ggccgcagca ggatcagcgg aaatgaagga atgtcctcca tcttaatggt 15121 gtctccgcac ggatatccgg cttcatctga aagcacaagc acacatggaa tgtcatcaag 15181 ctgcttgaat tgtactgtgt cacttttgat cagtgttgtc gtgaccgccg catcgatttg 15241 ccggctttcc agcagttcca acagtgtcgc gggctcattt tcccaaatat taaaggtgag 15301 atgggggtat ctctctttga tctgtgttac tttttcaagc atcagagccg cgcaataaat 15361 cgttgagccc acggcaagtg tgccggcaac ttcctccttc agctcctgta cctcaatgac 15421 tgcatcttca aacctatgca gaatctcttt tgctcttttt agaaaaacag ctccttcata 15481 tgtaagagtc atttgttttt tcttgttacg gtcaaacaga acaacaccaa gttcgtcctc 15541 cagctgtttg agctgcctgc ttaaaggcgg ctgcgccatg tgaagctttt tggctgctga 15601 cgtaattttc tgttcttggg caatggtaat gaagtatcga agctggcgaa tatccaaaag 15661 aaagcgcctc cttatcatac cttttaggta ttaaatatag atttaataga tatttttcat 15721 atggatatat caggagtatg attgaaatga aagcagaatt caagcgtaaa ggagggggca 15781 aagtgaaact cgttgtcgga atgacagggg caacaggggc cattttcggg gtcaggctgc 15841 tgcagtggct gaaggccgcc ggagtggaaa cccatctcgt tgtgtctcct tgggcaaacg 15901 tcacgatcaa acacgaaaca ggctatacct tacaagaagt agaacaactg gccacataca 15961 cttactcaca taaggatcag gcggcagcca tttcaagcgg gtcgtttgat accgatggaa 16021 tgattgttgc gccgtgcagc atgaaatctc tcgcaagcat tcgcaccgga atggcggata 16081 atctgctgac acgtgcggcg gatgtcatgc tcaaggagag aaaaaaactc gtcctcttaa 16141 cgagagagac gcctttgaac caaattcatc tcgaaaatat gctagcgctt acgaaaatgg 16201 gcaccatcat tcttcctccg atgccggcat tttataatca gccgagaagc ttagaggaaa 16261 tggttgacca tattgttttt agaacgttgg accaattcgg cattcggctt cctgaagcga 16321 agcgctggaa tgggattgaa aaacaaaaag gaggagcttg atcatggctt atcaagattt 16381 cagagaattt ctcgctgccc ttaaaaaaga aggacagcta cttacagtga atgaagaggt 16441 aaagccggaa ccggatttag gggccgccgc acgggcagcc agcaatcttg gcgataaaag 16501 ccctgcgctc ttatttaaca acatttacgg ctatcataac gcgcgaattg cgatgaatgt 16561 catcggctct tggccaaacc atgccatgat gctgggcatg ccgaaagaca caccggtaaa 16621 agaacagttt tttgaattcg caaagcgtta tgaccagttt ccgatgccgg tcaaacgtga 16681 ggaaacagcg ccatttcatg aaaatgaaat cacagaagat atcaatttgt tcgatatact 16741 gcctcttttc agaattaacc agggtgatgg aggctactat ttagacaaag catgtgtcat 16801 ttcccgtgat cttgaggacc ctgacaactt cggcaaacaa aatgtcggca tttacagaat 16861 gcaggtcaaa ggaaaagacc gtctcggcat tcagcctgtc ccgcagcacg atattgcaat 16921 ccatctgcgc caagctgaag aacgcggcat caatcttccg gtcaccattg cgctcggctg 16981 tgagccggtc attacaacgg cggcatcgac tccgcttctc tatgatcaat cagaatacga 17041 aatggcaggc gcgattcaag gcgaaccata tcgcatcgtc aaatcaaagc tgtctgatct 17101 tgatgttccg tggggcgctg aagtggtgct tgaaggtgag attattgccg gagagcgcga 17161 atatgaaggg ccgttcggtg aattcacagg ccattattcc ggcggacgca gcatgccgat 17221 tatcaaaatt aaacgcgtct atcacagaaa caatccgatc tttgaacatt tatacttagg 17281 catgccttgg acagaatgcg attacatgat cggcattaac acatgcgtgc cgctttatca 17341 gcagttaaaa gaagcgtatc cgaacgaaat tgtggcagtg aacgccatgt acacacacgg 17401 tttaatcgcg attgtttcca caaaaacccg ctatggcgga tttgcgaaag cggtcggcat 17461 gcgcgcactc acaacgccgc acggactcgg ctactgcaaa atggtcattg tcgttgatga 17521 ggatgtcgat ccattcaacc ttccgcaggt catgtgggcg ctttcgacca aaatgcatcc 17581 gaaacacgat gcggtcatca ttccggactt atctgtcctg ccgcttgatc cgggatccaa 17641 tccatcagga atcactcaca aaatgattct tgacgccact acaccggttg cgccggaaac 17701 aagaggccat tattcacagc cgcttgattc tccgctaaca acgaaagaat gggaacaaaa 17761 actaatggac ttaatgaata aataaggaaa ggatgttcga aatgcataca tgtcctcgat 17821 gcgactcaaa aaagggagaa gtcatgagca aatcgcctgt agaaggcgca tgggaagttt 17881 atcagtgcca aacatgcttt tttacatgga gatcctgtga accggaaagc attacgaatc 17941 ccgaaaaata caatccagcg tttaaaattg atccaaagga aacagaaaca gcaattgaag 18001 ttccggcggt gccggaacga aaggcttgat ccgcgtgaac agtttgtcag accgtctctt 18061 tgagctgctt gacgggagat gcctgagtga gaagcagcat gaggccttcg ttctgcaaac 18121 agtatcagag gatggctggc cgcatgccgc tatgatcagt gcaggtgaaa ttatcgcgct 18181 gagccgaact gatatccgaa tcgctctgtg gaaaaacaca atgacttcgg ccaacatcct 18241 tcgcacagga aaagcacagt tcacggcgtg gtggaaggga gcggcctatt atgtaaagct 18301 tgaatgcgcg cctttaccgc ctttgaaaga tgctgaatat gatagagacc gtttttcctg 18361 ccgcatcgtt tcagtgaagg aggacgttgc gaaatacgct gatttgactt caggtgtccg 18421 tatacagctt cacagcgctg aagaggtgct gagcagatgg gaaaagaccc tggaagattt 18481 aaagcggtaa tatcgatagc ctgacgccat gcgtcaggct ttttttatat aatgaaaaca 18541 aagggggcgt gagaaatgga acgtgcgggg atctgtcact cggacggctt tgatttagct 18601 tatcgaattg agggcgaggg cgcacccatc cttgtgatcg ggagtgcggt ttactacccg 18661 cgcctttttt cctcagatat caaacagaaa tatcaatggg tctttgtcga ccatagggga 18721 tttgctaagc ttaagcgagg gcttcgtgcg gaggattcga ggcttgatgc cgtcttggct 18781 gatatcgaaa ggatgagaac atttcttcag tttgaggata ttattatcct ggggcattcc 18841 gggcatgctt ttatggcttt ggaatatgcc aggacatatc ctgaacatgt ccggaaggtg 18901 gcgctcttca atactgcgcc tgataacagt gaagaaagac agcgaaaaag cgaatcattt 18961 ttcatggaaa cagccagtct tgagagaaag aaacgctttg aaaaagacat cgtgaatttg 19021 ccgcaggaca tcgaaaaaga tcctgaaagg cgcttcgtgc acatgtgtat tcgcgctgaa 19081 gcgaaaagct tttatcaaga gcggccgcat gctgcggcct tatgggacgg tgtattcacg 19141 aatatgccga tcattgatga attatggggc aatacatttg cccggattga tcttattcag 19201 cggttagctg atgttcgtat gccggtgtat attggattag ggagatatga ttatttggtt 19261 gcgcccgttg cgctatggga tgcagttgac aatttatatc cccatgtgga taaggttatt 19321 tttgaaagga gcggccatca gccaatgctg gaagaaccgg aagccttttc tcaaagcttc 19381 agcaaatggc tggatcaata aaaaaacagc ccgcagatca acatccgcgg gctgtttctg 19441 attataagac ccctttcatc gcgcgtttga taaccggcga gagcagcagg agaatgccgc 19501 caagaacgat agaaatcaaa ccgatggtgc cgaagtacat tgtttcagga attttatcaa 19561 acaatccggc tacttgggca ttgatcgctt gtgctgctgc gttcgtcaga aaccacatac 19621 tcattgtctg tgcagagaag gcagctggtg ccagtttcgt tgtcacggat aaaccgactg 19681 gagacaggca cagctctcca agcacgacaa gcaggaagct gagaacgagc caaagcgggc 19741 ttacgagtgc ttcttttcct tgcatagcag ggaataccat aatgataaat gacaatccgg 19801 ctaaaataat tccgattgag aatttaactg gtgtagacgg ctggcgtttg ccaagcttca 19861 tccagagcca tgcgaatatt ggcgcaaaaa tgacgacaaa caatggattt aatgattgga 19921 accaagatga ctgaagttcg aatccgccca atgaaagtct tatgcgttca tcagcgtata 19981 ccgcaagaat ggtcgctccc tgttcctgaa tggcccagaa catgacagca ccgataaaca 20041 aaggaacgta agcggcaaga cgggattttt ctgttttgtc cgcttttttg cttgtaaaca 20101 tgatgatgaa ataaatcaca ggaatcaaaa taccgagaat acttacaagg tcgataaaac 20161 gattgatcgt cagcacgcct gtttgtacag agataatcac tgcgatcgcc acgatgataa 20221 caccgattcc ggtgccaatc gcagattttt tagacagcgg attcggcaca ttggaacctg 20281 caagcccgag gtttttcttt cttgtcaaag caaatacgat aagtccgaga agcattccga 20341 ctgcggcagc tccgaatccg agatgatagt tgtacttctg tccgagtgtt ccgacaatta 20401 acggcgcgag taaaccaccg aggttaatcc ccatgtagaa aatactgaaa cctgagtcgc 20461 ggcgcgggtc ttctttcgtg taaagatccc caactacgct tgaaacgttt ggttttaata 20521 agcctgttcc gacaatgata agcaccatac tgatatagaa tgctatcgaa ctgcccggat 20581 aggcgagtgc aatgtggccg aacataatga atatgccgcc gtaaaacacg gtgtttgcgg 20641 taccgaatac ccggtcagcg agccatccgc caataatggt ggacatgtat acgagtgatc 20701 cgtaaatcga cataatggca accgcagtgc ccttgtcaaa gccgagccct ccgtttaccg 20761 tctctgtata caaatagtaa agtaagattg ctctcattcc atagtaagag aaacgctccc 20821 aaaattcggt gaaaaatagt gtaaatagtc ctcgcgggtg accaaagaac cctttttgcg 20881 ggacgctctt aatgatactt tcgttatcaa tcgaagccat gtcagccaaa ccctttctaa 20941 aaaaagtgta ttataaaaat catattctta tataatactt gtgtcaatat aatttatact 21001 catttcaaat agttccatat tggaaaaatt ataaatacct aaaaatagtg atttcctcct 21061 aatttttaaa ctttttatcg tgagattttc ttacacaact attcctttat atttttttta 21121 ataaaatttt agagaaatgt acaagcagat cgggcctttg tgagtaacat gatagtaatc 21181 atagagaagg aggctcgcaa ttggctgaat tcatattaaa tgcagcggat ttcggtgttc 21241 ctggagatgg taaaacggat tcgacagaac ggattaatca gtgcctcagt acagctgttt 21301 cgaaaggcta tcatactgtc tggtttccaa agggaacata tttaatagac gcaacgcttg 21361 gcggagatct taatcagagg tttcgaaacg cggggatcat tgttcccggc aaccttgaga 21421 ttatgatgga ccccgaatgt atcatgaaag tgatcccgaa tagttcgtgg ggttattccg 21481 cattttatgt gggcaagcaa gagaatataa ccatttccgg gggacaaatt atcggcgaac 21541 gggatgagca tacgtatgcc tcggcaggga taaggtcaac ccatgaatgg ggctttggca 21601 tatgtattga aggatgctcg aatgttgtca ttgatgatgt gaaaatttct gattttaccg 21661 gcgatgggat catagtcagc ccaaggggat taaagaccaa tcaagattat cgaacgtcag 21721 agcaaattat catccgccgc tgtgaggttc ggcggtcgag gagaaataac atttccatta 21781 ccggatgtga catggtcacg gtggaggaat gcttgattga agatgccgga acggggaatg 21841 gaacagcgcc gaaattcgga attgacattg aaggatatgg cgaaggtgat gttgattatg 21901 aggaaccgat taatgtatca attcgcaata accactttgt tggaaacgtt tcaagttctg 21961 tgaccaattt taacgggtat ggcattttaa tagaaggaaa tcactctgac aatacaatca 22021 gctacggata tgggacgcaa acagtgatca agggcaatat tctgagacgc cctgaagacg 22081 cggcggctgc gccaagagtc gggataaccg gactcggtgt atcacaagga aaagagacca 22141 gtgatgcagt gatcgctggc aacctcatta ccggattttc aactggaatt gatgtcagag 22201 gaaagagcgt tcttgtgacg aacaacaaaa tcagcaactt tgaaaacaca gggatattgg 22261 tttatcagtc ttccgatgta aaggtagacg gaaaccaaat tcaaaacgga ctgtctgaaa 22321 caaggcgcag catcggtctt cgcgcagtgc tgtcagatga catcgctttt ctgaataact 22381 gtctcattca agtcgttgac ggtgtgagcg tttcgggcgg aaacatgatc attaaagata 22441 atctcctgag aaaattcagc cgaggcattt ggattgctca agggaacgcg gtgattgaag 22501 ggaatacact gaatcctggc gcgtttgaag cagtgccgga atcatattct gtttccgtta 22561 caaacaatgc cggcgctatc atcaaaaaca atacatttaa agagtttaaa aattacccca 22621 tttactgctc cacaagtgca aaaacctcaa ttatcggcaa ccacttagag agatctccgc 22681 ttttggtcac catctatatc agcgccggtg tgcatgagat ttttgataat accatttcag 22741 tcaacagaac agccgggaat ccgattgtga tttatctcaa tggctctgca ggctctatca 22801 tctcaggaaa caccatcaat aacctctccg cgggcactgc gacagctatt caaacaaaca 22861 cgtcaaccaa ttccaaaatc atcggcaacc gcatttttaa agggactatc aacaaacaca 22921 gcagtgatgc aatagacggc aatattatcg tctgaaaaaa gcgccccctc taggggttct 22981 tttttttcga tttatagatc acgtacattt ctctcacaag tactaacaca aaaaataaaa 23041 gcacgaccca ttccgcaaat gttgtcatct taaagctgga catattgtta taaatggctt 23101 ttgttaaact gaacccttga agcatgtcca tcaatacaga aatagctaat aaacaaatta 23161 atatgactcc tgtcacgccc aatatcttca tgcttcatca tcctccgctt ttagtgtcta 23221 tcgttggcgg agaagttata ccgcatctaa acctaatgca taatctcaat tttaaaagga 23281 agaatatgag aaaacgacaa ggaaaggtat ttgtgtatgc ctttattttc taagcgaaag 23341 aacaatacaa gttcgaaaga caagcgcaat acagaagaaa agaatcagga acagaagcaa 23401 gaaaaagaaa ggccggttct catttctcca agtatggcaa agaatatagc ggaaacgaaa 23461 aaggaagtcg gaagcagctc tgacgtcatc attcgcgaga ttaaaatcgg ggagcaggat 23521 catgtccacc tagctgttat ctatattgct gggctggtcg ataataacac gatccatgag 23581 tcgttaattg acccattggt acaggatgag tctatccaga atactcatgc gatccagcaa 23641 attcttgaaa aaacgctccc gctgggcggg gtgaaagcgg aaaagagctg ggacaagctt 23701 ttttccgagt taatgctcgg caatgcgctc atttttgctg atggccatga tgaagctttg 23761 atttgcagca ctcaaggggg agagcagcgc tccatccaag agccgagcac ccaggtgtca 23821 ttccgcggcc cgcgccaagg gtttacagag tctctgcaaa ccaatatttc catgattcgg 23881 cgatacatta aaaatcccaa tttatgggtc gaaaaaatga aaaaaggttc tgttacgaat 23941 acggatatcg ctctcatgta cattcaagga atatgtgatg aaaaggtgct gaaggaagtg 24001 aaacagcgcc tggaaaaaat agatattgac agtattttgg aatctggata tattgagcag 24061 ctgattgaag atgaaacctt tacgacgttt ccgactatgt atcatacaga acgccctgat 24121 gttgtagcgg gtaatctgtt agaaggaaga ttcgcaatta ttgtggacgg aacaccgttt 24181 gtgcttatag ccccggcctt atttgtccag ttttttcagt ctgttgagga ttattattcg 24241 cgttttgaca ttgcgacaag cataagaatt cttcgtgttt tagtcttttt catttcgctt 24301 gtggctccgg ctgtatacgt ggcagccacg acgtttcatc aagaaatgat accgactcag 24361 ctgttagtgg tcattgcggc ccagcgggaa attgtcccgt ttccagctgt tgtggaggcg 24421 ttgacgatgg aggttgcttt tgagattctg agggaagcgg gagtcaggct gccccgggtt 24481 gtcggctcgg cagtgtcaat cgtaggcgcg ctcgtaatcg gccaggctgc cgtacaggct 24541 ggtatcgtct ctccggcaat ggtgattttc gtggcactca ccgcgattgc gagcttcgca 24601 acaccggcgt ttgcaatggc gatttcagcc cggcttattc ggtttatctt tattattgcc 24661 tcagctgtta tgggttttta cgggctgatt ttagggatca ttatgatgtt tgtccactta 24721 tgcagtcttc gttcattcgg cgttccatat atgtcgccgc ttgcaccttt ttcttcacaa 24781 ggcgtaaagg acgcgctttt ccgggttccg tggtgggccg atgaaaaaag gccggaatcg 24841 gtcagcaagg aagataaggt gcggcagggg aaagatcaac gcccagagcc ggccgcttca 24901 cgaggaatgg tgaacaaaga tttggaagaa ggggatcaga atggtacgta aatgtctatt 24961 agccgttctc atgcttttga gcgtcattgt gctgcccggc tgctgggata agcgggagct 25021 gacggatctt gcgattatct cggcgattgg catcgatcgg acaaacgaca gcaactacgt 25081 gctgcatctt caaattatca atccaggaaa tgttgccggc ggccttcagg gaggcggtgc 25141 tggagacagg ccgcctgtat ctgtctattc gattgaaggt aacaatataa cggaagcact 25201 cagaaaagcc tccatgaagg tatcacggcg gctttatttt gcccatacca atctagtcgt 25261 gatcaatgaa aagctggcaa aagaagaagg tttggatttt gtattagata atcttgaccg 25321 ggacacagaa ttcaggacaa cagcaacatt cgtcgttgcc cataaaacaa aagcagaaaa 25381 tattgtgaaa atcttgacgc cgattgataa aattccgtca aataaagtca ataaaacact 25441 cgatttcacg gaggcacaat acgggcgggt ggtcaaaatc aatattcagg acgttttgaa 25501 aacacttgcc gccaacacta tggcaccggt catccccgga tatatgatga ttggtgacga 25561 taaaaaagga gtcagcatgg aaaacac //