LOCUS       gnlProkkaGKAFKPJL_20   15795 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|GKAFKPJL_20.
ACCESSION   gnlProkkaGKAFKPJL_20
VERSION     gnlProkkaGKAFKPJL_20
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2025-04-28 20:33:48
            Original ID  :: gnl|Prokka|GKAFKPJL_20
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15795
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15795
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[1337:5795]"
                     /cutoff="20000"
                     /detection_rule="((LANC_like and (Lant_dehydr_N or
                     Lant_dehydr_C)) and not (YcaO or TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1338..5795
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="((LANC_like and (Lant_dehydr_N or
                     Lant_dehydr_C)) and not (YcaO or TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     cand_cluster    1..15795
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="((LANC_like and (Lant_dehydr_N or
                     Lant_dehydr_C)) and not (YcaO or TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..15795
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="lanthipeptide-class-i"
                     /region_number="1"
                     /rules="((LANC_like and (Lant_dehydr_N or Lant_dehydr_C))
                     and not (YcaO or TIGR03604))"
                     /tool="antismash"
     CDS             105..275
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Antimicr18"
                     /gene_functions="biosynthetic-additional (lanthipeptides)
                     predicted lanthipeptide"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg20_1"
                     /sec_met_domain="Antimicr18 (E-value: 3e-07, bitscore:
                     23.8, seeds: 2, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEKNNIFDLDINKKMESTSEVSAQTWATIGKTIVQSVKKCRTFTC
                     GCSLGSCSNCN"
     CDS_motif       105..176
                     /prepeptide="leader"
                     /note="peptide class: {self.peptide_class}"
                     /note="predicted sequence: MEKNNIFDLDINKKMESTSEVSAQ"
                     /locus_tag="ctg20_1_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       177..275
                     /prepeptide="core"
                     /locus_tag="ctg20_1_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="14.10"
                     /molecular_weight="3235.8"
                     /monoisotopic_mass="3233.6"
                     /core_sequence="TWATIGKTIVQSVKKCRTFTCGCSLGSCSNCN"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MEKNNIFDLDINKKMESTSEVSAQ"
                     /leader_location="[104:176](+)"
                     /alternative_weights="3253.8"
                     /alternative_weights="3271.8"
                     /alternative_weights="3289.8"
                     /alternative_weights="3307.8"
     CDS             363..1337
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075:alkaline serine protease, subtilase family
                     (Score: 154.5; E-value: 9.1e-47)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg20_2"
                     /sec_met_domain="Peptidase_S8 (E-value: 6.6e-27, bitscore:
                     87.8, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNMTTNALPNQFSWNSYKVTNGYRLYDLQVGSPLIKIAVIDSGYD
                     PNHSEITGNIDKKKSCSFVDYENFNEDLYGHGTAVISVIVGKNQVKGVAPGITIISYKV
                     LDRNGFGKIEWVIHAILKAIEDCVHIINLSHVFTMFGLGNKGAFNKLQQAIDKARKKGI
                     IIVGAAGNQGVLLDMKSTSLYPTIKGINYVTSTNKNNYTSSYANIGSIIRFAAPSGELD
                     ETNNVTDLIIVAHPTNFPKTKFEKAIGLPDFYTVTCGTSISAAMFSSLIALVLTEYLIC
                     KQIHLSEKEILNIIQKNSSRVKDQNSIFEINAYSVIKFIKGLL"
     CDS             1338..4448
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155:Lantibiotic dehydratase domain protein (Score:
                     768.1; E-value: 2e-232)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg20_3"
                     /sec_met_domain="Lant_dehydr_N (E-value: 3.6e-133,
                     bitscore: 438.2, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 6e-09,
                     bitscore: 29.8, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 2.2e-32, bitscore:
                     106.0, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNTKYLSSDLFMYRKPILDLSFYKECLAFDNEFNEEEYIAKISNL
                     LNTNPTIAEAIYFASEPLYNSFLNIEKLKKKKRKSVIDSMLKFLIRMSTRPTPFGLFSG
                     IGVETFSGQDEYLTKDSEVIKNTRLDMCWIYFLIRKLESNLSILEQLTVENNSLVYNHG
                     DRIKLSYQSLLHSDDNDQSLEMLTLRKTAVMDYVYSQAEFGINYSTLRDSINKTYSVTD
                     DISNDFLNSLLKNEVIITNLRTSLVNSDPFENILNIISKMHNVEEELNYLVRLKKSIEE
                     YKKSSGELGISILKKIKKEMRVIGYEGDDFLRTDLYYVRNKKRYINNNQKDSIEKLAEI
                     LSLLGSVNSFQPLEAYRDEFIDKYGIFQEVPLLELIDEELGIGLPPEYHENRHKPSQPE
                     PSNEFHRIKNIISSWQAEVSLSKNHEIKLDDEKIKHLFNSEELNNIAVSQELELYFNIL
                     LDEHKENKLYLNPNCGSNSLFQTYGRFKYFLGESDKEYIKQFSHIEKDVIFAEVTYYPT
                     HGKTANIINAETCFDYEIAFSCNSSKDNKHSIALSDLYVGSTYNFIYLKSKKLDKIIIP
                     KLSHMFNYSMGPKVYRFLVDIGVQYQKQWSNIDSFFYDAPIKPRVIYNNIVLSPKKWNL
                     NKSIIPFECDSGEKFHYYIKDWKKRYKVPDFIYLIEFDNKLLLNLENISHIKIIYNEFK
                     KLSNNQSLHFLEAEKELFNNHNNEIEEYVFTLKSKLHQLELDSYMTNIQSEMPFKYIGD
                     NERLKFLGTEWIYVKLYGLGTRENEFIADELGSFIKKHLDKGTIKSSFFIRYSDPKQHL
                     RVRFKVEKNNIFDTVLPIIIKWLEEMRTKGFVNYYCFDPYNPEIERYGGEQSYKIAEDL
                     FFCDSLIVSEWIQINRSGNVNIDEVTFGVFNILQLLKLFNLNIEEQMTWLEINTKPQKY
                     ANKFRGKKSTLIELADLIYTNKKLDKYNKISSIIEIREKTAITYSKSIENNPDFLIKNI
                     IMSVIHMHCNRLYGINRDKENLVIGLAYHTIKNYNNALKYNNVLIPN"
     CDS             4473..5795
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140:Lanthionine synthetase C family protein (Score:
                     333.9; E-value: 2.2e-101)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg20_4"
                     /sec_met_domain="LANC_like (E-value: 9.3e-63, bitscore:
                     205.3, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQKCKNPDFLTDILLDIANSIKDKSETEKIILGDQNNPEDIIEVV
                     SLAAGYPGICVFLGYMDKVFPEDGWDVVAHDYLTDLISLIQTNKTYSLSLFNGLAGVLV
                     ALETCSRGGTRYTTIINQVLTLILENYKHYLSEDLLKLKKEGVSASEYDVISGWTGVGR
                     TLLHFDQISNKGDISLKKALHDIAEYLLLVSSIDTLSNMPNWLISNENLPLDIEKKTYK
                     KGYFNSGMAHGISGVLAFLSILKKENYKIKNLELGIKNIQNWIFEKVKTHKGIYYIPNV
                     IENEVVRNEAFFNHRDAWCYGTPGVSRAIFLSGIALNDQRVKMKALELFKTFFLRDEKD
                     RKIISPTICHGYAGILMLTLRMYKDTNDRFLADKMHDILNEMLTFYSQLNFSKFNNYEL
                     ISGKIVEEKKVGLLEGSTGIALVLISFIFGQDSWDKIFLIS"
     CDS             5808..6398
                     /locus_tag="ctg20_5"
                     /transl_table=11
                     /translation="MIQAVLEITIKFLTELISFELPVYMYIWFAVLFIFSMIVENVQLA
                     IAKDSILNSILKRLGIKILSLLVVLIIGVLGSNFFAQVVEDAVNKESNLAYYILSTTIA
                     TALTIIEPIIETMKKFIKEQSNLAFANFTVSVICLTVTFQAVSSIFSDYFILATPYKVV
                     LIISSAIGIVYLVKFDQNNLEVNSESVHSNKND"
     CDS             6416..8173
                     /gene_functions="resistance (resist) ABC_efflux (Score:
                     251.8; E-value: 8.4e-77)"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 316.8; E-value:
                     4.7e-96)"
                     /gene_kind="transport"
                     /locus_tag="ctg20_6"
                     /transl_table=11
                     /translation="MGNNHLLLLLKLVKWPKKILVYILFSLLFTTILSLVIPILTKNTV
                     DQFTDGTVNWALTIMLAGLFLINILLSGLSFYYLAFLGENATYYIRDKMFSHILDLPLT
                     FFDKNESGQIVSRVIDDVELMNTFISDKIPNFASQLIVVAGSLILLFVLDWKITLLMLI
                     SVPISLAVMIPLGNKMYKISLEKQNNMAIFTARISSAFSGIRLTKSYTAEKEEYGKGNV
                     ILKRIFKLNLKDTKIQAYMMPIMSTVILMIILLLVGYGGIRLSEGTISPGTFVAIIFYL
                     VQFVTPLSSLSNFFTEYKKTLGATKRLYEIYSLKPEAENKQISSNAFNLGNGDLKFENI
                     SFQYNDPSSEVFNKLNLRFPKNKITAVVGPSGAGKSTLFNLIERLYEAQNGEIYYESTP
                     IKDIDLTVWRKKIGYVMQDTLMITGTIKENLTYGLSGSVSQETIIKYSKLANAHDFIME
                     LPDNYETFIGERGIKLSGGQKQRIAIARALIKNPEILLLDEATSNLDSESEILVQQSIN
                     RLVRDRTTIIIAHRLSTIRDADNIVFLENGVVTGSGNHLDLINNHEKYREFVNGQLLNN
                     TSISASSLS"
     CDS             8375..9352
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg20_7"
                     /sec_met_domain="PF00561 (E-value: 2.1e-08, bitscore: 27.4,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTLWKVLKIVFVSLAALVLLVSVSVFIYHHFQLNKEAALLKGKG
                     TVVDVDGKKMNVYQEGSGKDTFVFMSGSGIAAPAYEMKGLYSKFSKENKIAVVDRAGYG
                     YSEVSHDDRDIDTVLEQTRKALMKSGNKPPYILMPHSISGIEAMYWAQKYPKEIKAIIA
                     MDIGLPQQYVTYKLSGVDRLKVRGFHLLTSIGFHRFMPSAVYNPEVIRQSFLTDEEKEI
                     YKAINFKQFFNADMEHELLQSYQNGSKSVNLPAPKETPVLILDAVSDQNRHSKYAIQNR
                     KDYEAFAAQFNTADIKELRGTHSIYLYQPDQIYKLSMEFMRKVR"
     CDS             9354..10025
                     /gene_functions="regulatory (smcogs) SMCOG1008:response
                     regulator (Score: 127.8; E-value: 7.7e-39)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg20_8"
                     /transl_table=11
                     /translation="MKGYHILIVEDDVMIGELLQKILQREGYRVIWKTDGADVLSVIQK
                     VDLVIMDVMLPGEDGYQMSAKIKELGLGIPVIFLSARNDMDSKLQGLQIGEDYMVKPFD
                     PRELLLRMRNMLEHHYGTFTQIKHLYIDAVTKKVFNESLHDEVLFTAIERKIFFYLYEN
                     RDSILTKEHFFEYLWQLEDRNPNIVNVHIKKIRAKINDQAGEMIENIYGEGYRLNTVVK
                     K"
     CDS             10022..11008
                     /gene_functions="regulatory (smcogs) SMCOG1003:sensor
                     histidine kinase (Score: 59.4; E-value: 5.8e-18)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg20_9"
                     /transl_table=11
                     /translation="MKLKTKYQLLLFTAVISVPMLLLAVSVLMSVIYDSMFKPMNHGMP
                     FHRSFAYPAMIVVFLISLLLLAFLFSKSIHSLLHKINLLNQTIRHLASDQRVPDKIEVK
                     RADEIGELIKSVNLLIERTTYRELELRQQEEIKKELLQKLRHDINTPLTALRLQLFYLE
                     DQCHGQAVFESLYQQIEYISELTNEFNLYSAETLESSYIVNEEVRLNELLETAVKKWDY
                     LYSMSGIELHYKAADQDVIWMSNALWMQRLFDNIFQNTLKHSKAEKMEVTIEHDNVFIR
                     DDGIGFDRNESSEGLGLKIIEDTCRLLAITYELHTNDSGTGFLFSKE"
     CDS             11067..11318
                     /locus_tag="ctg20_10"
                     /transl_table=11
                     /translation="MNSICLKKSSKRLSTSQAVLVTDIADTGITAAAGADIIAATAARA
                     KEDTTTVMAAVIVTNAGATAAVNPKKFLFRFWDKGFFM"
     CDS             complement(11311..12081)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs)
                     SMCOG1030:serine/threonine protein kinase (Score: 109.6;
                     E-value: 3.1e-33)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg20_11"
                     /sec_met_domain="Pkinase (E-value: 4.3e-33, bitscore:
                     108.0, seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MALKLLKKLLFDRPLKNGVILNHQYKIEECLGMGGYGLIYLCTDI
                     LTQTPYVLKQLRPTKAKKEKEKVRFQQEIKLLKSIHHPQIPGFIDEFIIDGQAYYVMQF
                     IEGENIEELLFFRKQPFTELMALQLISQLLEIIEYLHDRLIFHSDIRTPNIIINDGRLC
                     LIDFGLAKQLTPEEMEEIKVRKQDDFFDLGETLLFLLYSQYKGKKKKNGTWLEELTLTK
                     EVTLLLKRLLGIEEEYQHTASIREDLNRAIQSVT"
     CDS             complement(12167..13024)
                     /locus_tag="ctg20_12"
                     /transl_table=11
                     /translation="MVKKWLIPFAVMLSVLFTFTYSASAAGVTAITGNNSFDTAMPIGY
                     WKYKNIDTTILEAGQDEAYFTFTANKGEKVYVRSTYQSAYTGMKIEIYDKNRIPVSQGT
                     EVINPNTFSSFIYANADAQNTTDTFYVKVSRGTYTGNMYFTLSIEDRIKSGSGTFQFSG
                     VAENKGNTSLSPSGSDSSVIKVDLTNQSGIPRDAIVTRVQTTATQTPSQGNTRHLIMTN
                     ENNEWRRALVNSSTSGSYDISLSDQLSVAKVWSFKYNTLATARSTMSNVKAKIDYEYDV
                     TKQF"
     CDS             13156..14340
                     /locus_tag="ctg20_13"
                     /transl_table=11
                     /translation="MRLNRQFIRTQLMAQNILSKNAPAKRENATENPAAVLEKAYSRLK
                     SQSSTGGINQFNYSKISVSGNSGTFSKVYQSANDRTVTDTGEETVIQSQNPYESESDIR
                     IKILDEKYSRMNAINKTKSDPLGYIKDKYQNSKSPYFRSDLSAAERQAAYDNETEWLFK
                     GKAQNYNLQDAAFRNVTFHGEVEAENEKVYQRGQVNQQLQVLLNRNHIYIPEGTELTFT
                     ITPIDYQVRVSGTDDQDLIKQIEQVLQSGDNSKELFLHIMKSQSSDSAQFSEEAYQKYQ
                     AAREMYEVTGYHLKDLEVIDGRYVTPDGRDLLDVYKEELEKDPVQKQTASYAISYYRSE
                     LSKIAEAGYNAIPEFILSIDYSNGSLRDVGQRKSYGTGDTGWLEALKRQTGVNY"
ORIGIN
        1 aaataattaa aaaatgtccc aaaaaaagta ttgactaact ttttttggga tagtactatt
       61 gaattgcaac cggttgaaag tatcaaaaaa aggaggaaat ggaaatggag aagaataata
      121 tttttgacct agacattaat aaaaagatgg aatctactag tgaggtttct gctcaaactt
      181 gggctacaat cggaaaaact attgtgcagt ctgtgaaaaa atgtagaaca tttacttgtg
      241 gatgttcgct aggctcttgc agtaactgta actaattagg ggatgagcag agggagttaa
      301 aatacatact atattaaaac tccctcttct tctaaagaca aggagtaaac aattccataa
      361 atatgaatat gactacaaat gctttaccta accaattttc ttggaactct tataaagtaa
      421 caaatggata taggctatat gatcttcaag ttgggagccc tttaattaag atagctgtaa
      481 ttgatagtgg gtatgatcct aatcattccg agattactgg aaatattgat aaaaaaaaat
      541 cttgttcatt cgttgattat gagaatttta atgaagatct atatgggcac ggtacagctg
      601 ttattagtgt gattgtaggg aaaaatcaag ttaaaggagt agctcccgga attacaatta
      661 ttagttataa agttctagat agaaatggtt ttgggaaaat agaatgggta atacatgcta
      721 ttttaaaagc cattgaagat tgtgtccaca ttataaattt aagtcatgtt tttactatgt
      781 tcggattggg aaataaagga gcattcaata aacttcagca ggccattgat aaagccagaa
      841 agaaaggcat aataattgta ggggcagcag ggaatcaagg agttttatta gatatgaaga
      901 gtacaagttt ataccctaca attaagggaa ttaactatgt cacctcaaca aataaaaata
      961 attacacctc atcttacgca aatattgggt caattattcg atttgctgca ccatcagggg
     1021 aacttgatga aacaaataat gttacagact taataatagt tgcacatccc acaaattttc
     1081 caaaaacaaa gtttgaaaaa gcaattgggc ttccggactt ttatacagtt acatgtggaa
     1141 ctagtatatc agcagctatg ttttcgagtc taatagcatt agtattgact gaatatttga
     1201 tatgtaagca aattcaccta tcagaaaaag aaattcttaa tataatccaa aaaaactcct
     1261 cacgagtaaa agatcaaaat tctattttcg aaataaatgc ttatagtgta ataaaattta
     1321 tcaaaggatt gttataaatg aatacaaaat atttaagctc agacttgttt atgtatagaa
     1381 agccgatatt ggacttatcg ttttataaag agtgtttagc ttttgataat gaatttaacg
     1441 aagaggaata catagcgaag ataagtaact tattaaacac taatcccact atagcagagg
     1501 ccatttattt tgcaagtgaa ccactatata attctttttt aaatatagaa aaattaaaaa
     1561 agaaaaagcg caagagtgtt attgatagta tgctaaagtt tttaataaga atgagtacaa
     1621 gaccaactcc atttggcctt ttttcaggta ttggggttga aacattttca ggtcaggatg
     1681 aatatttaac taaagattct gaagttataa aaaatactcg tttggatatg tgttggatct
     1741 atttcttaat aagaaaatta gagagtaacc ttagtattct cgagcagtta actgtggaaa
     1801 ataactcact ggtttataat cacggtgata gaatcaaatt aagttatcaa agtctattac
     1861 acagtgacga taatgatcag tcattagaaa tgttaaccct tagaaagaca gcagtaatgg
     1921 attatgtcta ttcgcaagca gaattcggta tcaattactc tacgttaaga gatagtataa
     1981 ataaaacata tagtgttact gatgacatat caaatgattt tttaaatagt ctattaaaaa
     2041 atgaagttat tataactaac ttaagaacat ctcttgttaa ttctgatcct tttgaaaata
     2101 tattaaacat aattagtaaa atgcataatg tagaggaaga attgaattat ttagttcgat
     2161 taaaaaaatc gattgaagaa tacaaaaaat cttctgggga attaggtata agtattttaa
     2221 agaaaatcaa aaaggaaatg cgagtaatag gatacgaagg ggatgatttc cttagaacag
     2281 atttgtatta tgtgagaaat aaaaaacgat atattaataa taaccaaaaa gatagtatag
     2341 agaagctagc tgagattctt tctctattag gatcagtaaa ctctttccaa cctttagaag
     2401 cctatagaga tgagttcatt gataaatatg gtatttttca agaggtacct ctcctcgaac
     2461 tcatagatga agaattaggt attggtttac cacctgaata tcatgaaaac aggcataaac
     2521 catcacaacc agaaccgagt aatgaatttc ataggataaa aaatattata tcttcttggc
     2581 aagcggaggt gagtttatcc aaaaatcatg agattaaatt agatgatgaa aagattaaac
     2641 atttatttaa ctcggaagaa ttaaataaca ttgcggtatc acaagaatta gaactttatt
     2701 ttaatatttt acttgatgaa cacaaagaaa ataaactcta tttaaatcct aactgtggtt
     2761 ctaattctct ttttcaaaca tatggaagat tcaaatattt tttgggtgaa agtgataaag
     2821 agtacataaa acaattctca catatagaaa aagatgttat ttttgcagag gttacgtatt
     2881 atcctaccca tggaaaaact gctaacatta taaatgctga aacatgcttt gattatgaga
     2941 tagcttttag ctgtaattcg tccaaagata ataagcactc aattgcgttg tctgacttat
     3001 acgttgggtc aacatataac tttatttatc ttaagtcaaa aaagttggat aaaatcataa
     3061 taccaaaatt aagtcatatg tttaattatt caatgggccc taaagtttat agatttcttg
     3121 ttgatattgg tgttcagtat caaaaacaat ggtctaatat agatagtttc ttttatgatg
     3181 ctccaattaa accgagggtt atatataata atattgtatt atcacctaaa aagtggaact
     3241 tgaataaaag tattattcca tttgaatgtg actctggaga aaaattccat tactatataa
     3301 aagattggaa gaagagatat aaggtacctg attttatata tttaatagaa tttgataata
     3361 aacttctgct gaacttagaa aatatctcac acattaaaat tatctataat gaatttaaga
     3421 agctttcgaa taatcaatca ctacattttt tagaagcaga gaaagagttg tttaataatc
     3481 ataacaatga aatagaagaa tacgttttta ctttaaagtc aaagttacat caattagaac
     3541 ttgattctta tatgacaaat attcagagtg aaatgccttt taaatatatt ggtgacaatg
     3601 aaaggcttaa attcttaggt acagaatgga tttatgtgaa attatatgga ttaggcacta
     3661 gagaaaatga atttatagct gatgaacttg gctcgtttat aaaaaaacat ttagataaag
     3721 gtactattaa gtctagcttt ttcattagat atagtgaccc taagcagcat ttacgtgtta
     3781 gatttaaagt tgaaaagaat aacattttcg atactgtact cccgattata ataaaatggt
     3841 tagaagaaat gagaacaaag ggttttgtta attattattg tttcgatcca tacaaccctg
     3901 aaatagaaag atacggaggg gaacaatcat ataagattgc agaagattta tttttttgtg
     3961 actcattgat tgtttctgag tggatacaaa ttaacagatc tggaaatgtt aatattgatg
     4021 aagtgacctt tggagttttt aatattcttc aactattaaa attatttaat ttaaatattg
     4081 aagagcaaat gacatggtta gaaattaata caaaaccgca gaaatacgct aataaattca
     4141 gagggaaaaa aagtacttta attgagctgg cagacttaat ctatactaat aagaaacttg
     4201 ataaatataa taaaatctca agtattatag agatacgaga aaaaactgca atcacctatt
     4261 ctaagagcat agaaaataat ccagatttct taataaaaaa tattataatg agtgtaatac
     4321 acatgcattg taacagatta tatggaataa acagggacaa agaaaactta gttattgggt
     4381 tagcatatca taccattaaa aattataata atgctctaaa gtataataat gttttaatcc
     4441 ctaactaaat tttaattgaa aggaaagaat taatgcagaa atgcaagaat ccagattttt
     4501 taaccgatat ccttttagat atagctaatt caattaaaga taagtcagaa accgaaaaaa
     4561 taatacttgg tgatcaaaat aatcctgaag atataattga agtagtatca ttggcagcag
     4621 gatatccagg aatttgtgtg tttttaggtt atatggataa agttttccct gaagatggat
     4681 gggatgttgt ggcacacgac tatttaacag atttaatttc cttaattcag actaataaaa
     4741 catactcact atccctattt aatgggttgg caggtgtttt agtggctctt gaaacttgct
     4801 ctagaggcgg aacaagatat actacaataa taaatcaagt gctaacccta attttagaaa
     4861 actataaaca ttatttgtct gaggacttgt tgaagctaaa gaaagaggga gtgtccgctt
     4921 ctgaatatga tgttataagt ggttggacag gtgttggaag aaccctattg cattttgatc
     4981 aaatatcaaa taaaggagat atttcattaa aaaaagcatt gcatgatata gcagaatatt
     5041 tactgttagt tagcagtatt gatactctaa gtaatatgcc aaattggctt atatccaatg
     5101 aaaaccttcc tttagatatc gagaaaaaaa cttataaaaa aggatatttt aattctggca
     5161 tggcgcatgg aatttctgga gttttagcat ttttatcgat tctgaaaaaa gaaaactata
     5221 aaataaagaa tttagaatta ggtattaaaa acattcaaaa ttggatattc gaaaaggtaa
     5281 aaacacacaa aggaatttat tatataccta atgtaattga aaatgaagtt gttagaaatg
     5341 aggctttttt taaccacaga gatgcctggt gctatggtac accaggtgtg tcaagagcaa
     5401 tctttttatc aggtatagct ttgaacgatc aaagagttaa aatgaaagcc ctagaactgt
     5461 ttaagacatt ttttttacgt gatgagaaag atagaaaaat tatatccccc acaatttgtc
     5521 atggatatgc cggcatatta atgttgactc taagaatgta taaagatact aatgaccgat
     5581 ttctagctga taaaatgcat gatatactta atgaaatgtt aactttttac tctcaattaa
     5641 acttttccaa attcaataat tatgaattaa taagtgggaa aattgtagaa gagaaaaaag
     5701 tgggtttgtt agaaggaagt acgggaattg ccttagtttt aatttctttc atttttggtc
     5761 aagattcgtg ggacaagata tttctgataa gttaaagggg gataaaattg atacaagcag
     5821 tactagaaat cactattaaa tttctaacgg aattaatctc ttttgaattg ccagtatata
     5881 tgtatatttg gttcgcagtt cttttcatat tttcaatgat agtcgaaaat gtacaattgg
     5941 caatagctaa ggatagtata ttaaattcta ttttaaaaag attaggaata aaaattttaa
     6001 gtctattggt ggtcttaatt attggggttt taggatcaaa cttttttgct caggttgttg
     6061 aagacgcagt caataaagaa tctaacttag cttattatat tctgtctact acaatagcta
     6121 cagcattgac cataatcgaa ccaataattg agacgatgaa aaagtttata aaagaacaat
     6181 caaatcttgc ttttgcaaat tttacagtca gtgttatttg tcttactgta acgtttcaag
     6241 cagtctcaag catctttagt gattatttta ttttggccac cccttataaa gtggtgttaa
     6301 taatttcatc agcaattggt attgtatatt tggtgaaatt cgatcaaaat aatttagaag
     6361 ttaatagcga aagtgttcat tcaaataaaa atgattaatc taagaggtta tacatatggg
     6421 caataaccat ttactattac tgcttaaact tgttaaatgg ccaaaaaaaa tattagtata
     6481 tattttattt tcattactat ttacaactat actatccttg gtaataccaa tattgactaa
     6541 aaatactgtt gatcaattca ctgatggaac agtaaattgg gccttaacaa taatgttagc
     6601 aggtttattt ctcataaata ttttattaag tggattatct ttttattatc tagcattttt
     6661 aggtgagaat gcgacttact atatacgaga taaaatgttt tctcatattt tagatttacc
     6721 tctaacgttt tttgataaaa atgaatctgg tcaaattgta agtagagtta tagatgatgt
     6781 tgagttaatg aatactttta tttctgacaa gataccaaac tttgcttctc aattgatagt
     6841 agttgccgga tcattaattc ttctgtttgt gctggattgg aaaataacat tacttatgtt
     6901 gatttctgtt cctatttcat tagctgttat gattccattg gggaataaga tgtataaaat
     6961 ttctttagaa aaacaaaata atatggcaat atttactgca agaataagta gtgcattttc
     7021 aggaattaga cttacaaaaa gttatactgc agaaaaagaa gagtatggga aaggtaatgt
     7081 cattttaaaa agaattttta agcttaatct aaaagatact aagatacaag cttatatgat
     7141 gcctattatg tctactgtta tactaatgat aatattattg ttagtggggt atggggggat
     7201 aaggttatcg gaaggaacta tttcaccagg tacctttgtt gcaataattt tttacttagt
     7261 tcaatttgtt acacctcttt cctctctgtc taactttttt actgaatata aaaaaacact
     7321 aggtgcaaca aaaagattat atgaaatata ttcactaaaa cccgaggccg aaaataaaca
     7381 aattagcagt aatgcattta acttgggaaa tggggatctg aaatttgaga acatttcgtt
     7441 tcagtataac gatccttctt ctgaagtatt taacaaactg aatttgcgtt ttccaaaaaa
     7501 taagataaca gctgttgtag gtccttctgg agctggaaaa tcaactttat ttaatttaat
     7561 agaacgtttg tatgaagctc aaaatggtga aatctattat gaatcaactc ctataaaaga
     7621 cattgatttg actgtttgga gaaaaaaaat tggttatgta atgcaagata ctttgatgat
     7681 caccggcacg ataaaagaga acctgacgta cggtttatca ggctctgtat ctcaagaaac
     7741 tataattaaa tattctaaat tagccaatgc ccatgatttt attatggagc ttccagataa
     7801 ttatgaaacc tttattggag aaaggggtat aaaattatca ggtggtcaaa aacaaagaat
     7861 tgcaatagca agagcattaa ttaaaaaccc tgaaatactt ttattagatg aggcaacttc
     7921 taatttagac agtgaaagtg aaatattggt acaacaatct ataaatagac tagttcgaga
     7981 tagaaccact attattatag ctcatagatt gtcaacaatt agagatgcag ataacattgt
     8041 atttttagaa aatggagtgg ttacaggaag cggtaatcat ttggacctaa taaataacca
     8101 tgaaaaatac cgagagtttg ttaacggtca attgctaaat aacacttcaa taagcgcgag
     8161 ttctctaagt taattgtgca taaataatga gaccacttgg gtacactttt tatcggttct
     8221 ataaccataa aaagcagctg aacttttagt tcagctgctt tttgattgaa tcttgcgact
     8281 agaaagtcaa atgtgaaaat aaaactgttc caaagttaat cagaaattta ttttcatatt
     8341 gtatcctttc agtatcacgt gaaaggagca tcatatgaaa acattatgga aagtcctaaa
     8401 aattgttttt gtcagcttgg ctgctttggt tttgcttgta tccgtctcgg tatttattta
     8461 tcaccatttc cagctaaata aggaggcggc actgctgaaa ggtaaaggca cagtagtcga
     8521 tgttgacggt aaaaagatga atgtgtatca agagggaagc gggaaggata cgtttgtgtt
     8581 tatgtccggt tcggggattg ctgcgcctgc ttatgaaatg aaggggctgt acagcaagtt
     8641 ttcaaaagaa aataagattg ctgttgtaga tcgggcaggt tatggataca gtgaagtgtc
     8701 tcacgatgac agagatattg atacggtatt ggaacagacg aggaaagcgc ttatgaaaag
     8761 cggaaataag cctccttata ttttaatgcc tcattcgata tccgggattg aagcgatgta
     8821 ttgggcacag aaatatccta aggaaatcaa ggccattatt gcgatggata ttggattgcc
     8881 ccagcagtac gtcacgtata aattgagcgg agttgacaga ttgaaagtga gagggttcca
     8941 cctgttaacc tcgattggtt ttcatcggtt tatgccttcc gctgtatata atcctgaggt
     9001 gattcggcag tcgtttttaa ctgatgaaga aaaagaaatc tataaagcca ttaactttaa
     9061 gcaatttttt aatgcagata tggagcatga gcttttacag tcttaccaaa acggcagcaa
     9121 atctgtgaat ctgccggcac caaaggaaac tcccgtcttg attttagatg cggtctctga
     9181 ccaaaataga cattcaaagt atgctataca aaaccgaaaa gactatgaag cgtttgcggc
     9241 tcaattcaat actgccgata taaaggaact gaggggaaca cacagtattt atttatatca
     9301 gcctgatcaa atatataaac tgtccatgga gtttatgaga aaggttcgct aggatgaagg
     9361 gatatcatat tttaatcgtg gaagacgatg tgatgattgg tgaattgctg caaaagattt
     9421 tgcagcgtga gggatatcgt gtgatatgga aaacagatgg agcggatgtg ctttcggtga
     9481 ttcagaaggt ggatttggtc attatggatg tgatgctgcc gggtgaagac gggtatcaaa
     9541 tgtctgcaaa aatcaaagag ctggggctgg gcattccggt aatttttctt tcggcccgta
     9601 atgatatgga cagcaagctt caaggtttac agatcggcga ggattatatg gtaaagccct
     9661 ttgatccgag agagctgcta ttaagaatgc ggaatatgct tgagcatcat tatgggacct
     9721 ttacgcaaat caaacatttg tatattgatg cggtaacgaa aaaagtgttc aatgaaagcc
     9781 tgcatgatga ggtattattt actgcgattg agcggaaaat tttcttttat ttatatgaaa
     9841 atagagacag tatcctgaca aaggaacatt tctttgaata tctatggcaa ctcgaagata
     9901 gaaacccgaa tattgtcaat gtgcatatta aaaaaattag agctaaaatc aatgatcaag
     9961 cgggtgagat gattgaaaat atatatggag aagggtatcg gctgaatacc gttgtgaaga
    10021 aatgaagctt aagacaaaat atcagttgtt attgtttacg gccgtcatta gtgttccaat
    10081 gctattgctg gcggtaagtg ttttgatgtc ggtgatttat gacagcatgt ttaaaccgat
    10141 gaatcatggt atgccctttc acaggtcgtt tgcgtacccg gcaatgatcg ttgtattttt
    10201 gatatcactc ttattgttag cttttttatt ttcaaagtcg attcattctc tgttgcataa
    10261 aatcaatcta ttaaatcaaa ccattcggca tttggcgagt gatcaaaggg tgcccgataa
    10321 aattgaagtg aagcgtgctg atgaaatcgg ggaactgatc aagtcggtca atttgttaat
    10381 tgaacggacg acatatcgtg aactggagct gagacagcaa gaggaaatca aaaaggagct
    10441 tttgcaaaaa ctgcggcatg acattaatac acctttaacg gctctcaggc tgcagttatt
    10501 ttatttggaa gaccaatgtc atggtcaggc tgtattcgaa tcattgtatc agcaaatcga
    10561 atatatctcg gaattaacca atgaattcaa tctatattcc gctgagacgc tggaaagctc
    10621 ttatattgta aatgaagaag tgcgtctaaa cgagctatta gaaacagcgg tgaaaaagtg
    10681 ggattattta tacagtatga gtgggattga gctgcactat aaggcggcag atcaagatgt
    10741 gatatggatg agcaacgcgt tatggatgca aaggctgttt gataatattt ttcaaaatac
    10801 gttaaagcat tcaaaagctg aaaagatgga agtcacgatt gaacatgaca atgtttttat
    10861 tcgtgatgac ggtattggat ttgatcggaa tgagagcagt gagggacttg ggttaaagat
    10921 tattgaggat acatgcaggc tgcttgcgat tacttatgag ctgcatacaa atgatagcgg
    10981 aacggggttc ttgttttcaa aagagtgacc ccgctgatgt ttttctttct cctataaaat
    11041 ttatataata gggagaaaga aatggggtga acagcatatg tttaaaaaaa tcatcaaaac
    11101 gattaagtac ctctcaagca gttctagtga ccgatatcgc agacaccggc attacagcag
    11161 cagccggcgc agacattatc gcagctacag cagctcgggc aaaagaagac actacgaccg
    11221 ttatggcggc agtcatcgtt acaaacgccg gagctacagc agcagttaat ccaaaaaagt
    11281 tcttgttccg cttttgggac aagggttttt ttatgtgacc gattgaatgg cccggtttag
    11341 atcctcgcga atggaagcgg tgtgctgata ctcttcctca atgcccaata atcttttcag
    11401 cagcaaggtt acttcctttg tcagtgttaa ttcctccagc caagtgccgt ttttcttctt
    11461 ttttccttta tattgagagt acagcaggaa taacagcgtt tctccgagat cgaagaagtc
    11521 atcctgtttt cgtaccttta tttcctccat ttcttcagga gtcaattgtt tggcaaggcc
    11581 gaaatcgatg aggcagagcc tgccgtcatt gatgatgata ttaggcgttc tgatgtcgct
    11641 gtggaagata aggcgatcat gcaggtattc tataatctca agcagctgcg aaatcagttg
    11701 taacgccata agctctgtga acggctgttt tcgaaaaaat aataattctt ctatattctc
    11761 tccctcgatg aactgcatga cataataagc ctgtccgtct atgatgaact catctatgaa
    11821 gcccggaatt tgcgggtggt gaatgctttt gagcagtttt atttcctgtt ggaatcggac
    11881 tttctctttt tcctttttcg cttttgttgg ccgaagctgt tttaaaacat aaggtgtttg
    11941 agttaggata tcggtgcaca aataaatcaa accgtagcct cccataccga ggcactcttc
    12001 gattttgtat tgatgattta agataacgcc gttctttaga gggcggtcaa aaagcagttt
    12061 ttttagaagt tttaatgcca tgtctgcact tcccttggtt gtactgacta tagtttacct
    12121 tctagacgga gaataaaaaa gagccggata accggctcgg tataagttaa aactgctttg
    12181 tcacgtcgta ttcataatct atttttgctt ttacgttgct catcgtcgat ctggctgtcg
    12241 ctaatgtatt atatttaaaa ctccatacct ttgccacact gagttgatct gacaaagaga
    12301 tatcataaga ccctgaagtc gagctgttta caagagcacg gcgccattcg ttgttttcgt
    12361 tcgtcatgat caggtggcgt gtatttccct ggcttggtgt ttgagtggcg gttgtctgaa
    12421 ctctggttac aatggcatca cgcggtatcc cggattggtt tgttaaatca accttgatca
    12481 cgctggagtc agaacctgag gggctaaggc ttgtatttcc tttattttca gcaacgccgc
    12541 tgaattggaa cgttccgctg cctgatttga ttcggtcttc aattgaaagc gtaaagtaca
    12601 tgtttccagt ataggtgcct cgtgacactt tcacataaaa ggtatccgtc gtgttttggg
    12661 catctgcatt tgcataaata aaagaagaaa acgtattagg gtttatgact tctgtccctt
    12721 gagaaacagg tattctattc ttatcataaa tttcaatttt catccctgta tatgcgctct
    12781 ggtatgtact cctcacgtat actttttctc ccttattagc cgtaaaagtg aaataggctt
    12841 catcttgacc agcttccagt attgttgtat cgatattttt atatttccaa taaccgatcg
    12901 gcattgcggt atcaaatgaa ttgtttcctg tgatagcagt gactccggca gctgatgccg
    12961 aatacgtaaa ggtgaataag acagacagca taacagcgaa tggaataagc cattttttca
    13021 ccatgcaaac aacctccttt tatttccatc atacataata acgatttagg tgtaaataaa
    13081 tgttttttga ggttaatata tacattgtat ttgccgataa aaaagaataa gagagaatac
    13141 tcgggaggga attcaatgcg tctgaatcgg caatttatcc gcactcagct gatggcacag
    13201 aacatattga gcaagaatgc gcctgccaaa cgggagaatg cgactgaaaa tccagcggca
    13261 gttctggaaa aggcatacag caggcttaag tcacaatctt caactggggg aatcaatcag
    13321 ttcaattatt ctaaaatcag cgtgtcggga aacagcggga cattcagcaa agtgtatcaa
    13381 tcagcgaatg atcgaacagt gacagacaca ggggaagaaa cagtgattca atcccaaaac
    13441 ccctatgaat ctgagagtga tatcagaatc aaaatactag atgaaaaata cagcaggatg
    13501 aatgcgatta ataaaacaaa gtctgatcca ttaggctata ttaaggataa gtaccaaaat
    13561 tcaaagtctc cttatttcag aagtgatctg tcagctgcag agagacaggc cgcttacgat
    13621 aatgaaacag aatggttatt caaagggaag gcgcaaaact ataacctcca ggatgctgcg
    13681 tttcggaatg tcacatttca tggggaagtg gaagctgaga atgaaaaggt gtatcagcgg
    13741 ggacaggtta accagcagct gcaagtgctg ttgaatcgaa accatattta tattccagag
    13801 gggacagagc tgacgtttac aatcacaccg attgactatc aggtgcgggt gagcgggaca
    13861 gacgatcagg atctgatcaa gcagattgag caagtgctgc aatctggaga caacagcaaa
    13921 gaactatttt tgcacatcat gaaaagccaa agcagtgatt cagcacaatt ttccgaagag
    13981 gcctatcaaa agtatcaggc tgctcgtgag atgtacgaag ttacaggcta ccatttaaag
    14041 gatttagaag tgattgatgg gcggtatgtc acgcctgatg gacgtgactt attagacgtc
    14101 tataaagaag aacttgaaaa agatccagtg cagaaacaaa cggcttctta tgctatatct
    14161 tactatcgtt cagagctcag taaaatcgcg gaagccgggt ataatgccat tccggaattc
    14221 atcctatcaa ttgattacag caatggatct ctgagagatg tgggacaaag gaagagctat
    14281 gggaccggag ataccgggtg gcttgaagca ttaaagcgtc aaacgggtgt gaattattag
    14341 gtaagctgtt catgtagaac agcttatttt ttatgagaat ctaaggggtg tattaatttc
    14401 aatattcaaa taattttatt atttttatat aaaagatttt aaaagaagtg aacgattcaa
    14461 aactctgaac aaaggtgttt acctgaaaaa aacaattgta ttttccagag aaatttatta
    14521 tgatgaaata agtaatttag gagattatat aacaatttta agtttgaatt ttctgattgt
    14581 tatcgctgat tcatgtgaag gcaagcaggt ctgctgtttt ctcatttatg ttaggaggag
    14641 gaagaggagt ggcaaataaa gaattaaaga ggggcctggg cgcgcgccat attcagatga
    14701 tcgccttggg cggtacaatc ggtgttggct tgtttatggg ttctgccagc acgatttcat
    14761 ggactggccc atctgtcctt ctggcttatg caatatgcgg aatttttatc ttttttatta
    14821 tgcgtgcgat gggtgaaatg ctgtatgtcg agccgagcac aggctctttt gcgacgttcg
    14881 gccatcaata tattcatccg atggcaggtt atataacagc atggagcaac tggttccagt
    14941 ggattatcgt cggcatgtca gaaattatcg ctgtcggttc ttatatgaag tattggttcc
    15001 cggatttgcc tgcttggata cctggtatcg tggcaatggt gattcttggt gcggcgaatt
    15061 taatttctgt taagtcgttt ggggaatttg agttttggtt tgcgatgatt aaaatcgtga
    15121 cgattatctt gatgattatt gcgggaatcg gaattatttt cttcggtttt ggcaatggcg
    15181 gagatgcgat cggtttgtcg aacctgtggt ctcacggggg cttctttgca ggaggtttct
    15241 caggtttctt ctttgcactg tctcttgtca ttgcggccta tcaaggagtt gagctgatcg
    15301 ggattacagc gggtgaagcg aaggacccgc aaaacacgct aagaaatgcg attcaaagta
    15361 ttatctggcg tattttgatt ttctacattg gcgctatttt tgtgatcgtg acggtgtatc
    15421 cttgggatga gctcaactca ctcggaagtc cgtttgtgtc tacgttctcg aaaatcggaa
    15481 ttacggcagc ggccggcatt attaactttg tcgtaattac tgcggcaatg tccggctgta
    15541 atagcggtat tttcagcgcg ggccgcatgc tatatacact gggtgtcaat ggacaagcac
    15601 cgaaattctt taagaagatt tcacgcaatg gtgtgccgct gtatggcaca attgcggtgc
    15661 tgatcggttt ggctgtcggt gttgtactga actatatcgc gccgccgaag atctttgtct
    15721 atgtatacag cgcaagcgtg ctcccaggga tgattccttg gtttatcatt ttgatcagcc
    15781 atatcggatt cagaa
//
