LOCUS       gnlProkkaKJGHMJMK_24   12529 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|KJGHMJMK_24.
ACCESSION   gnlProkkaKJGHMJMK_24
VERSION     gnlProkkaKJGHMJMK_24
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 19:22:16
            Original ID  :: gnl|Prokka|KJGHMJMK_24
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 8104
            Orig. end    :: 20633
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12529
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[10000:11747]"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11747
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
     cand_cluster    1..12529
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /kind="single"
                     /product="ranthipeptide"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..12529
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="ranthipeptide"
                     /region_number="1"
                     /rules="(TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085
                     or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /tool="antismash"
     CDS             complement(1024..3654)
                     /locus_tag="ctg24_12"
                     /transl_table=11
                     /translation="MLIEIDQAAISQDLALVGGERSHVQLKLLDGIAQNVGLDVLQVAL
                     EYFPHIGDEHIVPQTKGGGTCQLQGQHTPVDEVRAVTLGSVLGNDIGTGTQHTLAAGGL
                     LTGRAIAGLDRKDGRGNLDIVPVQLLAAGHGVHLCQQSSIPCTGTAGVLFGLHSLGAAH
                     ILRVLAAEGELGQTQGVRAVRRGLTGGDQLVGGGDGVGDIRSYLQQQVVAQRCDLRPVL
                     DVGAKLEQGIVIALAKALIHAGVVAGSIVLVLRHGGIIVNVGGGGQDAAVCGGGCNAAG
                     IHQCHTGQLAAAGLGALAAGEVAGGVTDGQCTVGGHIACAEAGAAEGGADGSAAGHQLA
                     NDAGAHQFHHDGLTAGVNAQGVVAAAAGMTLEDGSSLVDAVVQTACAACNDALIHTQLA
                     VFDLAAQIQLHVLAADQLLHILFAGVEDVLQVCVQLLNGKGVGGVHGQGDHGTDGRKIH
                     LHHAVIVGKVCRCKLFIVCCTAMHCQKTLGDFIGLPDGGQAGSLGGHGINGVAGILPQG
                     GNARAHELHDLVFDVATLEQLAHKGNGYIVGAAARRQTAGQVDGHHTRAGNIIGAAQQL
                     LCQLAAALADSHGAQCAVAGVGVRAKDHFAAAGKALTHILVDDCHVRGHKDTAVLFGSG
                     QAKAVVVLIDGAAHSAQAVVAVGKHIRDGELFQPGSTGGLDNAHKGDVMACHGIKLDLQ
                     VLGIAAGVVCLHNIVGHGTGLSRGNGSGIKALCCQCCGCIAICGHPLSARIVRTAGAAF
                     DHIQHLDSPLFLYFPARRNCGHCPGSAAIHPENSRPLSLHPLGGRWRTAPDEGYFLATA
                     PSSVACGDSFSKTYNPCPVTAKAVFNFYYSMKGRKEKAFFMNPYCAFAAASCCFSFCSL
                     RNTTK"
     CDS             3717..4532
                     /locus_tag="ctg24_13"
                     /transl_table=11
                     /translation="MPIERLASIAARTGLHAIALSDHDTLLSAQYAYAHTGQDGVELIP
                     AVELTGYDFDRQHRVHLLCYYPDVDCPALREHCAIMKERRNACALQSAKELEQLYPQFT
                     TDLAWETTKASGVLFKSGLMQALELLGLTDGSIYGETYHKLFGWNPRGIVLHSPEYLPV
                     RQVLATAKASGGAVVFAHPTVYKSMPLLRELAAEGAVDGIEVYHPSNSPEDSAECLALC
                     KQYGLVATAGTDFHGRNHKHPHPIGTCTAPDEAAAQLRAIAEKRKRERT"
     CDS             4538..4801
                     /locus_tag="ctg24_14"
                     /transl_table=11
                     /translation="MSKEFSFPNKGTCSKQTNFVLNDDHTIASIEVIGGCNGNLKGICQ
                     LLTGMKAEDAIARLDGTLCGFRSTSCPDQIAKNLKKALEEMN"
     CDS             5297..7012
                     /locus_tag="ctg24_15"
                     /transl_table=11
                     /translation="MDHKSAYIIGSGLAALTAACYLVRDGQMKGEHVHVFEKNALAGGA
                     CDGYKYDIGYVMRGGREMDNHFEVMWDMLHSIPSLETEGASVLDEYYWLNKEDPNFSLC
                     RATVNRGEDAHTDGKFGLSDKGAMEIMKLFFTPDEQLQDKKITDFFDDEVLNTNFWMYW
                     RTMFAFENWHSALEMKLYLKRYIHHIGGLPDFTALRFTRYNQYESIILPMVRYLESFGV
                     QFHYNTKVTDVKFDIQKGRKLASSVTVEHEGETTNIDLTENDLLFITNGGCVESCTVGA
                     QDKATGFDPTIQPGNGWDLWKKIAAQDPSFGHPEKFCSEPELSNWESATITTLDDKIPQ
                     YIRKICKRDPFSGHTVTGGIVTVKDSSWLLSWTLNRQQQFKDQPKNQLCVWVYGLFSDK
                     PGDYVKKPMRDCTGREICMEWLYHIGVPEDQIAELAEHSANTVPVMMPYIDAFFMPRAM
                     GDRPDVVPEGAVNFAFLGQFAETARDTIFTTEYSMRTGMEAVYTLLNIDRGVPEVWGST
                     YDVRALIDATVKLRDGKKITDMDLPLIPRLALKEALKKIEGTDLEKFLKEYNAI"
     CDS             7346..9061
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1283:2`,3`-cyclic-nucleotide 2`-phosphodiesterase
                     (Score: 249.4; E-value: 1.3e-75)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg24_16"
                     /transl_table=11
                     /translation="MTAAAASMAIGAPAASACWYGDKSDVTILYTNDVHTYIDKQSPKL
                     TYAAIADLKQSYQNAGKDVLLVDAGDHVQGTAYGSMDEGASIIKLMNAAGYDVATPGNH
                     EFDYGMDRAKAIMKEADFPYLSCNWVDLRTTLHVLPSVKVFVRGGRRIAFVGVTTPETF
                     TKSTPAYFMDKAQRKYIYDIQGGEDGKKLYDAVQKAIDKAKLLADVVIGLGHLGVDPSS
                     SPWTSEEVIAHTSGFDAFIDGHSHTVMENKQVQDASGKAVTLTQTGSYFANVGEMTIAA
                     DGTITTKLIPTHEGMDAGIAAMQTGWVNTVDDMLGEKIAVGDSDFYVSDPATGKRRIRS
                     AETNLGDFVADGIYTYFNEVEKLHCDVAIMNGGGIRADVPAGDWTFKTCKQVSPFGNVA
                     CLMSVTGKQIQDALEFAARFAGEDGKENGGFLQVAGATYEIHTDIPNTVQTDEKNVWIG
                     SATGTPRVQNVKIYDKASGSYLPLDLGATYALAGMNYTLRNLGDGFAMFDGAELIKDYV
                     SEDYLVMSTYAMIFDGADAAGLPHLSSANSPLAAYPGYLLNYEQPYGAGRITIL"
     CDS             complement(9149..9262)
                     /locus_tag="ctg24_17"
                     /transl_table=11
                     /translation="MHSGSAVDSDSTCGSSILSSPTRLKPSEEVQVAFLFI"
     CDS             9498..9785
                     /locus_tag="ctg24_18"
                     /transl_table=11
                     /translation="MPERTTQNAQTLLSPRVPRDTEHERYHPELEEELKECLFCLKRNE
                     MMFDMEVDTDLIEQRIYERQALLCRYRYLLARARELGLHTVLTRYQPMGG"
     CDS             9955..10053
                     /locus_tag="ctg24_19"
                     /transl_table=11
                     /translation="MRYCLSEKILTKGALRDILLQDKSVPELCPAR"
     CDS             10001..10228
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: SCIFF"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR03973"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg24_20"
                     /sec_met_domain="TIGR03973 (E-value: 9.1e-26, bitscore:
                     80.1, seeds: 29, tool: rule-based-clusters)"
                     /sec_met_domain="SCIFF (E-value: 5.3e-25, bitscore: 77.7,
                     seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MISYYKIKAYRNYVRRDKILRVREVSIMERIKTIATRDLTKSVKT
                     GGCGECQTSCQSACKTSCGVANQQCENSNK"
     CDS             10296..11747
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: Ranthipeptide_rSAM_RRE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR04085"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg24_21"
                     /sec_met_domain="Ranthipeptide_rSAM_RRE (E-value: 7.2e-31,
                     bitscore: 97.0, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 1.1e-15, bitscore: 48.6,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 8.9e-17, bitscore: 52.5,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 2e-20, bitscore: 63.6,
                     seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVHQYQLNGYNIVLDTCSGSVHVVDEVAYDVIAMYPEHTADEIVA
                     AMLAKYGSRPDVTEEDLRQCIDDVTSLKENGKLWSPDVYKDMAFDFKNRNTVVKALCLH
                     VAHSCNLSCSYCFASQGRYHGDRALMSFEVGKRAMDFLIENSGTRRNLEVDFFGGEPLM
                     NFDMVKKLVAYCREQEKIHNKNFRFTMTTNGVLIDDDVIDFCNKECHNVVLSLDGRKEV
                     NDRFRVDCAGNGSYDRIVPKFQEFVKKRGDKNYYMRGTYTHYNTDFTNDIFHMADLGFT
                     ELSMEPVVCDPSDPSALTEADLPILKEQYEILAKEMIKRDREGRGFTFYHYMIDLTGGP
                     CIYKRISGCGSGTEYMAVTPWGDLYPCHQFVGDPKYLLGDIWKGVTNTAVRDEFKHCNA
                     YARKECQDCWAKLYCSGGCAANSYHATGSITGVYEYGCELFKKRMECAIMIKVAENQEL
                     AAKGIEVPIELGSTCNACADGEACE"
     CDS             11744..12529
                     /locus_tag="ctg24_22"
                     /transl_table=11
                     /translation="MSMTTPIVDFVRSYAKSGTARLHMPGHKGQSLLGFEPLDITEICG
                     ADELYAPEGIIAESEANATRLFGTAHSYYSTEGSSQCIRAMLFLALQGAPQSGKRPVLL
                     AARNAHKALLYAAALLDFDIRWLWPSAQAEGALCSCPVTAEALTGALHAMAQQGNTPFG
                     VYVTSPDYLGGVQDIPALAAVCRAQGVPLLVDNAHGAYLRFLPQNCHPIAQGAAMCCDS
                     AHKTLPVVTGGAYLHLAHDAPVQDEAAVRGALALFGSTSP"
ORIGIN
        1 caccgccaat accgtgtggc tgtccatcgc ttttgccacg gtgctcacca tcgttacggt
       61 ggctatgacc cggctggtgc tggtgtggac gaacaccccg gctgacatca tcgaccttgc
      121 ggatgtgtat atccgcacca tttttgcagg catccccttt accttgcttt ataatgtgac
      181 cagcgccctg atgcgtgcac tgggcgacag caagcgcccg ctgtatttcc tgctggtggc
      241 cagcgtgctg aacatcgggc tggaccttgc ctgcatcatc ctgttcaaca tgggcgtgtt
      301 cggcgcggct tttgccaccg tgttcagtca ggctgtggca ggcatcggca gccttattta
      361 catcatgcgc cactacccgg aactgcgctg gaataaggaa gaagggcgca tcagcgctcc
      421 gcactgcgca aagctttgcg ccatgggcct ccccatgggt ctgcagtgca gtattactgc
      481 catcggcagc gtggtgctgc agggcgcggt gaacggtctg ggcagcgata tcgtagccgc
      541 gcagaccgcc ggcggcaagg ctgcgcagtt cctcagcgtg ccgctggaga gtatcggcac
      601 tgccatgacc acctacacca gccagaatat gggcgcgaag gatctgggcc gcgtgaaccg
      661 cggcgtgaac accgcactgg gcatcggctg cgtgtacagc gtggcctcct tcctcattct
      721 gcgcgtgctg gacaagcccc tgatcggcct gtttctggat gcaggcgaga ccgccattat
      781 ggccaatgcg caggacttca tcttctggaa cagcttgttc tacatcccgc tggcggtgct
      841 tatcatctat cgctacacca ttcagggtct ggggcactcc ggccttgcca tgtttgccgg
      901 tgtggctgaa atgatcgccc gcgccatggt gggcttctgg ttcgtgccgc tgtggggcta
      961 ctttgccgcc tgcatcgcaa acccggtggc atggctcttt gcctgcttct tcctgatccc
     1021 ggcctatttt gtggtgttcc gcagactgca aaaggaaaag cagcaggaag ccgccgcaaa
     1081 ggcgcagtaa gggttcataa aaaatgcttt ttcttttcgc cctttcatgc tataataaaa
     1141 gttaaatacg gcttttgccg taacagggca ggggttataa gtctttgaaa agctgtcgcc
     1201 gcaggcgact gatgagggtg ctgttgccaa gaaatacccc tcatccggtg ctgtgcgcca
     1261 ccttcccccc aaggggtgaa ggctaagggg acggctgttt tcgggatgaa tagccgcact
     1321 gccggggcaa tgcccgcaat tgcggcgggc gggaaaatac aaaaagagag gcgaatcgag
     1381 atgttggata tgatcaaatg cagcaccggc ggtgcgtact atgcgcgcgg agagtgggtg
     1441 cccgcagatg gcaatgcacc cgcagcactg gcagcaaagg gctttgatgc cgctgccgtt
     1501 gccgcggcta agaccggtac catggcctac aatattatgc aggcacacaa caccagcggc
     1561 gatgccgaga acctgaagat caagtttgat gccatggcaa gccatgacat cacctttgtg
     1621 ggcattatcc agaccgcccg tgcttccggg ctggaaaagt tccccatccc ttatgtgctt
     1681 accaactgcc acaacagcct gtgcgctgtg ggcggcacca tcaatgagga cgaccaccgc
     1741 tttggcctgt ccgctgccaa aaagtacggc ggtatctttg tgcccccgca catggcagtc
     1801 atccaccagt atatgcgtga gcgctttgcc ggctgcggca aaatgatcct tggctcggac
     1861 tcccacaccc gctacggcgc actgggcacc atggctatcg gcgagggcgg cggcgagctg
     1921 gcaaagcagc tgctgggccg cacctatgat gttgcccgcc cgggtgtggt ggccatctac
     1981 ctgaccggca gtctgccggc gggctgcggc ccccacgatg tagccattgc ccttgtgggc
     2041 aagctgttca agagtggcta cgtcaaaaac aaggtcatgg agttcgtggg ccctggcatt
     2101 gcctccctgc ggcaggatac ccgcaacgcc attgatgcca tgaccaccga gactacctgc
     2161 ctgtcctcca tctgggagac cgatgaagtc acccagcgtt ttctggcagt gcatggccgt
     2221 gcagcagact ataaaaagct tgcaccggca gaccttgcct actatgacgg cgtggtggag
     2281 gtggatcttt ctgccatccg tcccatgatc gccctgccca tgcacccctc caacgccttt
     2341 accattgagg agctgaacgc aaacctggag gacatcctcc acgcctgcga acaggatgtg
     2401 cagaagctga tcggccgcaa ggacgtgcag ctggatctgt gcagcaagat cgaaaacggc
     2461 aagctgcgtg tggatcaggg cgtcattgca ggctgcgcag gcggtctgta cgacagcatc
     2521 tacgaggctg cttccatcct caagggtcat accggcggct gcggcgacta cgccttgagc
     2581 gtttaccccg gcagtcagcc catcatgatg gaactggtgc gcaccggcgt cattggcgag
     2641 ttgatggcca gcggcgctac catccgcacc gccttctgcg gcccctgctt cggcgcaggc
     2701 gatgtgcccg ccaacggtgc actgtccatc cgtcacacca cccgcaactt ccccagccgc
     2761 gagggctcca agcccggcag cggccagctg tccggtgtgg cactgatgga tgcccgcagc
     2821 attgcagcca ccaccgcaaa cggcggcatc ctgacccccg ccaccgacat tgactatgat
     2881 cccaccgtgc cggagtacca gtacgatgct tccagctacg acacccgcgt gtatcaaggc
     2941 tttggcaagg gcgattacga tgccctgctc aagtttggcc ccaacatcaa ggactggccg
     3001 gagatcgcac cgctgggcga caacctgctg ctgaaggtag cttcttatat caccgacccc
     3061 gtcaccacca ccgacgagct gatcccctcc ggtgagacct cttcttaccg ctctaacccc
     3121 ctgggtctgg ccgagttcac cctcagccgc aaggacccgg agtatgtggg ccgcgccaag
     3181 gctgtgcagg ccgaagagaa cgcccgccgt gccggtgcag gggatgctgc tctgctggca
     3241 aaggtgaacg ccgtgcccgg ctgcgagcag ctgaactgga acgatatcca gattgcctct
     3301 accatctttg cggtcaagcc cggcgatggc tctgcccgtg agcaggccgc cagctgccag
     3361 cgtgtgctgg gtgccggtgc caatatcgtt accgagtacg ctaccaagcg ttaccgctct
     3421 aacctcatca actggggtat gctgcccctg cagctggcag gtgccacccc ctttggtctg
     3481 ggggactatg tgctcatccc caatgtgcgg gaagtactca agggcgacct gcagaacatc
     3541 aaggcctacg ttctgggcga taccgtcaag gagtttgagc tgtacatggc tccgctcacc
     3601 accgacgagc gccagatcct ggctgatggc tgcctgatca atttctataa gcactaagga
     3661 agtaacccgc tatgtcctgt gacctgcata tccattccac ctgctcagac ggtgctgtgc
     3721 ccatcgagcg gctggcgtcc atcgctgccc gcaccgggct gcacgccatc gccctttcgg
     3781 accacgatac cctgctcagc gcccagtacg cctatgccca caccgggcag gacggggtag
     3841 agctgattcc cgccgtggag ctgaccggct atgactttga tcggcagcac cgggtgcacc
     3901 tgctgtgcta ctacccggac gtggactgcc cggcgctgcg ggagcattgc gccatcatga
     3961 aggagcgccg caacgcctgc gctttgcaga gcgcaaagga gctggagcag ctgtacccgc
     4021 agtttaccac cgaccttgca tgggagacca caaaggccag cggggtgctg ttcaaaagcg
     4081 ggctgatgca ggcactggaa ctgctgggtc tgaccgatgg cagcatctac ggcgagacct
     4141 accacaagct gttcgggtgg aacccccggg gcatcgtgtt gcactcgccg gagtatctgc
     4201 cggtgcggca ggtgctggct accgccaagg caagcggcgg cgcggtggtg tttgcgcacc
     4261 ccacggtgta taaaagtatg cccctgctgc gggagctggc agcagagggc gcagtggacg
     4321 gcatagaggt gtaccacccc agcaacagcc cggaggatag cgccgagtgc cttgctctgt
     4381 gcaagcagta cggccttgtg gcgaccgcag gtacggactt ccatggccgc aaccacaagc
     4441 acccccaccc catcggtacc tgtaccgcac cggacgaagc cgcagcgcag ctgcgcgcca
     4501 tcgccgaaaa acgtaaaaga gagaggacgt aaagaccatg agcaaggaat tttccttccc
     4561 gaacaagggc acctgctcta agcagaccaa ctttgtgctg aacgatgacc acaccattgc
     4621 atccatcgag gtcatcggcg gctgcaacgg caacctgaaa ggcatctgcc agctgctcac
     4681 cggcatgaag gcagaggacg ccattgcccg tctggatggc acgctgtgcg gcttccgcag
     4741 caccagctgc ccggaccaga tcgcaaagaa cctgaaaaag gctctggaag agatgaacta
     4801 aaaccgatag agagccgctg cacagacctt tgtgcggcgg ctctcttttt gttgtacatg
     4861 gggagcatcc tcgccctctc cgtctttgct tcgcaaatcc acctctccca aagggagagg
     4921 ccttggcaaa gagatgaact ttgcgtggac tgccaagggc tcccactttg ggggagctgg
     4981 catcgcgcag cgatgactga gagggcgagc ccgctgaaaa tggcaagagc aaggcaacga
     5041 ctaagctgaa agattttgca tatcgctttt atgtcacaat ttgtacgcat ttccagcaaa
     5101 taagggcgga tgtaaaaaat ctatacaccg ggcaaagttt gtttgttgtt ccggttcact
     5161 ttgcggggta tactgttgcc atagagaaca gcacgatgaa ggctgtgaaa agatattttt
     5221 gaagcaggga ggctttttta tgtactattc cagtggcaat tatgaagctt ttgcacaccc
     5281 caaaaagccg gagggcgtgg atcataaatc cgcttatatc atcggctccg gtctggctgc
     5341 gctgaccgct gcctgctatc tggtgcgcga cggtcagatg aagggcgagc acgtccatgt
     5401 gtttgaaaag aacgcactgg ccggcggcgc ctgcgatggc tacaagtacg atatcggcta
     5461 tgtgatgcgc ggcggccgcg agatggacaa ccacttcgaa gttatgtggg atatgctgca
     5521 ctccatcccg tctctggaga ccgagggtgc cagcgtgctg gacgagtatt actggctgaa
     5581 caaggaggac cccaacttct ccttgtgccg cgccaccgtc aaccgcggcg aggatgctca
     5641 caccgatggc aaattcggcc tgtccgataa gggtgccatg gagatcatga agctgttctt
     5701 taccccggac gagcagctgc aggataaaaa gatcaccgat ttcttcgatg acgaggtgct
     5761 caacaccaac ttctggatgt actggcgcac catgttcgcc ttcgagaact ggcacagcgc
     5821 tctggagatg aagctgtacc tcaagcgcta tatccaccac atcggcggtc tgccggactt
     5881 taccgccctg cgctttaccc gctataatca gtacgaatcc attatcctgc ccatggtgcg
     5941 ctatctggaa agcttcggcg tgcagttcca ctacaatacc aaggtcaccg atgtgaagtt
     6001 cgacatccag aagggccgca agctggcaag ctctgttacc gtggagcacg agggcgagac
     6061 caccaacatc gacctgaccg agaacgatct gctgttcatc accaacggcg gctgcgtgga
     6121 aagctgcacc gtgggtgcac aggataaggc taccggcttc gaccccacca tccagcccgg
     6181 caacggctgg gatctgtgga agaagatcgc cgcacaggac ccctccttcg gtcacccgga
     6241 aaagttctgc tccgagccgg aactgagcaa ctgggagagc gccaccatca ccacgctgga
     6301 cgacaaaatc cctcagtata tccgcaagat ctgcaagcgc gaccccttca gcggccatac
     6361 cgtcaccggc ggcatcgtca ccgtcaagga ctccagctgg ctgctcagct ggacgctgaa
     6421 ccgtcagcag cagttcaagg atcagcccaa gaatcagctg tgcgtctggg tgtacggcct
     6481 gttcagcgat aagcccggcg attacgtcaa gaagcccatg cgcgactgca caggccgcga
     6541 gatctgcatg gagtggctgt accacatcgg cgtgccggag gatcagatcg cggagctggc
     6601 agagcacagc gccaacaccg tgcctgtgat gatgccctat atcgacgctt tcttcatgcc
     6661 ccgtgctatg ggcgaccgtc ccgatgttgt gcccgagggt gctgtgaact ttgccttcct
     6721 tggccagttt gccgagaccg cccgcgatac catctttacc accgagtact ccatgcgcac
     6781 cggtatggag gctgtgtaca ccctgctgaa catcgaccgc ggcgtgcccg aggtctgggg
     6841 cagcacctac gatgtgcgcg ctctgatcga tgccaccgtg aagctgcgcg acggcaagaa
     6901 gatcaccgac atggatctgc cgctgatccc gcgtctggct ttgaaggaag ctttgaagaa
     6961 aatcgagggc accgaccttg agaagttcct caaggagtat aacgctatct gatatttccc
     7021 tctcctccga tagacccggc aacgggtcaa caccccccta aaaaagacct ctccgctgct
     7081 ctacgacagg gcacgggaag gtcttttttg catgggattt gtgtaaaaat ggtacaatat
     7141 atgttaaaat aaagcggaac gtgaaaataa tttgtgccaa aagaatgatt ttggcttgtc
     7201 tgcggcggcg ttctgtgcta tgctagagct attgaaaggg caggagggaa gagcctgcct
     7261 caaatgcgat acgccaaaga taaaaggagg tcgttttcct gtgaaacaac ttatttcccg
     7321 tcgcagcttt ttaaaggctg ctggtgtgac cgctgccgct gcatccatgg ctatcggtgc
     7381 gcctgccgca tcggcctgct ggtatggtga caagtctgac gttaccatcc tgtacaccaa
     7441 cgatgtccat acctacatcg acaagcagag ccccaagctg acctacgctg ccattgccga
     7501 cctgaagcag agctatcaga acgccggcaa ggatgtgctg ctggtggatg caggcgacca
     7561 tgtgcagggc accgcctacg gctccatgga cgagggtgct tccatcatca agctgatgaa
     7621 cgctgccggt tacgatgtcg ccacccccgg caaccacgag tttgactacg gcatggaccg
     7681 tgccaaggcc atcatgaagg aagccgattt cccgtacctg tcctgtaact gggtagacct
     7741 gcgcactacg ctgcatgtgc tgccctccgt caaggtgttc gtgcgcggcg gcagacgcat
     7801 cgcctttgtg ggcgtgacca cccccgagac ctttaccaag tccaccccgg cctactttat
     7861 ggataaggca cagcgcaagt acatctacga tattcagggc ggcgaggacg gcaaaaagct
     7921 ctatgacgcc gtgcagaagg ccattgataa ggcaaagctt ctggcagacg tggtcatcgg
     7981 tctgggtcat ctgggcgtag acccctcttc ctctccgtgg accagtgagg aagtcattgc
     8041 ccacaccagc ggctttgacg cctttatcga cggccactcc cataccgtaa tggagaacaa
     8101 gcaggtgcag gatgcttccg gcaaggctgt caccctgacc cagaccggct cttactttgc
     8161 aaacgttggc gagatgacca tcgctgcgga cggcaccatt accaccaagc tcatccccac
     8221 ccacgagggc atggacgcag gcatcgccgc catgcagact ggctgggtga acaccgtgga
     8281 cgatatgctg ggcgagaaga tcgctgtggg cgacagcgat ttctacgtct ctgaccccgc
     8341 caccggcaag cgccgcatcc gctctgccga gacaaacctc ggcgactttg tggctgacgg
     8401 catctacacc tacttcaacg aggtggaaaa gctgcactgt gatgtggcca tcatgaacgg
     8461 cggcggcatc cgcgccgatg tgcccgcagg cgactggacc ttcaagacct gtaagcaggt
     8521 cagccccttt ggcaacgtgg cctgcctgat gtcggtcacc ggcaagcaga tccaggacgc
     8581 attggagttt gcagcccgct ttgcaggcga ggacggcaag gagaacggcg gcttcctgca
     8641 ggtggccggt gctacctacg agatccacac cgatatcccc aacactgtgc agaccgacga
     8701 gaagaacgtc tggatcggca gcgccaccgg caccccgcgc gtgcagaacg tgaagatcta
     8761 cgataaggcc tccggcagct atctgccgct ggatctaggc gctacttacg cactggccgg
     8821 catgaactac accctgcgta atctgggcga tggctttgcc atgtttgacg gcgcagagct
     8881 gatcaaggac tatgtgtccg aggattatct ggtgatgtct acctacgcta tgatttttga
     8941 cggcgcagat gctgcgggtc tgccgcacct gtccagcgcc aatagcccgc tggccgcata
     9001 ccccggctac ctgctcaact acgagcagcc ctacggcgca ggccgcatta ccattctgta
     9061 aatttatatt tcccgtgaaa aggcgaaccc ggaaagtcct gtggactttc cgggttcgct
     9121 ctatctataa tagtttttcc gcgcggaatc atataaacag aaaagccacc tgaacttctt
     9181 cagatggctt taatctggtt ggggatgaga gaatcgaact cccacaagta gagtcagagt
     9241 ctaccgcact accactatgc aaatccccaa tattctgttg tgttttgcgg ggtgagccgc
     9301 tcaacgtgtg ctattatacg ggaaaagccc ggagttgtca agcatatttt tgaaaaaagt
     9361 tgtacttttt tggaaaatgc cgcagcagcg ccggataatc tatgccggag cgctgccaca
     9421 cttcggcagg ttctgcgcac cgcaccgcct atactggaag gtacaaaacc ttgcaaagta
     9481 ccagaaggag gatgcctatg ccggaacgaa ccacacaaaa cgcccagacc ctgctttcgc
     9541 cccgcgtccc gcgggatacc gagcacgagc gctaccaccc ggagctggag gaggaactga
     9601 aggaatgcct gttctgtttg aagcgcaacg agatgatgtt tgatatggag gtggatacgg
     9661 acctcatcga gcagcgcatc tacgagcggc aggcgctttt gtgccgctac cggtacttac
     9721 tggcgcgcgc ccgggagctg gggctgcata cggtgcttac ccgctaccag cccatgggcg
     9781 ggtaaaaagg cttagggcaa caccgcacaa ttcccgcctt acggcttaag caccactccg
     9841 gcggttgcgg cacggcatct gcgttgccaa aatgctcgat aatacacaaa gtattatctg
     9901 cgcttttggc ttagcatctg ccgcacctca ctcgccgtat cggcacctag aattatgcgg
     9961 tattgcctta gcgaaaaaat cttgacaaaa ggcgcgctgc gtgatatcct attacaagat
    10021 aaaagcgtac cggaactatg tccggcgcga taaaattttg agagttagag aggtttctat
    10081 catggagcgt attaagacta ttgctactcg tgacctgacc aagagcgtta agaccggtgg
    10141 ctgcggcgag tgccagactt cctgccagtc cgcctgcaag acctcctgcg gcgtggctaa
    10201 ccagcagtgc gagaacagca acaagtaatt tttgcaaacc ctatgccgcc tttgccgggc
    10261 ggcatttttt tgtgtaatct ggaatggagt gtaaaatggt acatcagtat caattgaacg
    10321 gttataacat cgtgctggac acctgcagcg gctcggtgca cgttgtggac gaggtggcct
    10381 acgatgtcat cgccatgtac ccggagcata ccgcagacga gatcgttgcc gccatgctgg
    10441 caaagtacgg cagccgcccg gacgtgaccg aggaggatct gcgccagtgc atcgacgacg
    10501 tgaccagcct gaaggaaaac ggcaagctgt ggagcccgga tgtctataag gacatggcct
    10561 tcgactttaa aaaccgcaac actgtggtaa aggcgctgtg cctgcacgtt gcccatagct
    10621 gcaacctgag ctgctcttac tgctttgcct cgcagggacg ctaccatggc gaccgcgccc
    10681 tgatgagctt tgaggtgggc aagcgcgcca tggacttcct catcgagaac agcggcaccc
    10741 gccgcaatct ggaagtggac ttctttggcg gcgagccgct gatgaacttt gatatggtca
    10801 aaaagctggt ggcctactgc cgcgagcagg agaagatcca taacaagaac ttccgcttta
    10861 ccatgaccac caacggtgtg ctcattgatg acgacgtcat cgacttctgc aataaggagt
    10921 gccacaatgt ggtgctgagt ctggatggcc gcaaggaggt caacgaccgc ttccgcgtgg
    10981 actgcgcagg caacggcagc tacgaccgca tcgtgcccaa gttccaggag ttcgtcaaga
    11041 agcgcggcga caagaactac tatatgcgcg gcacctatac ccactataac accgacttta
    11101 ccaacgatat cttccacatg gcagacctcg gctttaccga gctgagcatg gagccggtgg
    11161 tctgcgaccc cagcgacccc agcgccttga ctgaggccga cctgcccatc ctgaaggagc
    11221 agtacgagat ccttgccaag gagatgatca agcgcgaccg cgagggcaga ggctttacct
    11281 tctaccacta catgatcgac ctgaccggcg gcccctgcat ctataagcgc atctccggct
    11341 gcggctccgg caccgagtac atggctgtta ccccttgggg cgatctgtac ccctgccacc
    11401 agttcgtggg tgaccccaag tacctgctgg gcgatatctg gaagggcgtt accaacaccg
    11461 ctgtgcggga tgagttcaag cactgcaacg cctacgcccg caaggagtgt caggactgct
    11521 gggcaaagct gtactgctcc ggcggctgcg ctgccaactc ctaccacgcc accggcagca
    11581 ttaccggcgt gtacgagtac ggctgcgagc tgttcaaaaa gcgcatggag tgcgccatca
    11641 tgatcaaggt agccgagaat caggaactgg ctgctaaggg tattgaggtg cccattgagc
    11701 tgggctctac ctgcaacgcc tgcgctgacg gcgaagcctg cgaatgagca tgaccacccc
    11761 catcgtggat tttgtgcgca gctatgcaaa gtccggcacc gcccggctgc acatgcccgg
    11821 ccacaagggg cagagccttt taggctttga gccgctggat atcaccgaga tctgcggcgc
    11881 agacgagctt tacgcgccgg agggcattat tgccgaaagc gaagccaacg ccacccggct
    11941 gttcggcacg gcgcacagct attatagtac cgagggctcg tcccagtgca tccgcgccat
    12001 gctgtttctg gcgctgcagg gtgcaccgca aagcggcaag cgcccggtgc tgctggctgc
    12061 ccgcaacgcc cacaaggcgc tgctatatgc ggcggcgctg ctggattttg acatccgatg
    12121 gctttggccg tctgcgcagg cagagggtgc actgtgcagc tgccccgtca cagccgaagc
    12181 gctgacaggg gctttgcacg cgatggcaca gcaggggaac accccctttg gcgtatacgt
    12241 caccagcccg gattatctgg gcggagtaca ggatattccg gcgctggccg ctgtctgccg
    12301 ggcgcagggc gtgcctttgc tggtggataa cgcccacggg gcctacctgc gctttctgcc
    12361 gcaaaactgc caccccatcg cgcagggcgc ggccatgtgc tgcgactctg cccacaagac
    12421 cctgccggtg gtcaccggcg gcgcgtatct gcatctggcg cacgatgccc ctgtgcagga
    12481 cgaagcggct gtgcgggggg cgctggcgct gttcggctct accagcccc
//
