LOCUS       c00217_gnlPro..        10884 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|MDNPHBBN_217.
ACCESSION   c00217_gnlPro..
VERSION     c00217_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 00:43:23
            Original ID  :: gnl|Prokka|MDNPHBBN_217
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 10884
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10884
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[863:9647]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      864..9647
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..10884
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..10884
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             2..721
                     /locus_tag="ctg217_1"
                     /transl_table=11
                     /translation="CSGAQIGVLTVEYTGNDSTEDYATQAFNAWGIGSSSKNNGVLILL
                     VMESAQYADGDYYLTYGDGFRNTTLAKQSSAIAQTMKDQFAAKNYDGAVTTCARNVANT
                     IADIYGVSLSGGNGSTVQPGYQGGQSSGGSTLTDILTLVVSVVLLIVIIRSMAYVFASP
                     CGWLWCFGGPRPPRGRRRGPHNPPPPGGFYGGFGGMGGGSFGGGAGRGGFGGGSFGGGF
                     GGMGSGSSHGGGGGRGR"
     CDS             864..2069
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: PALP"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg217_2"
                     /sec_met_domain="PALP (E-value: 2.6e-94, bitscore: 305.1,
                     seeds: 146, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLTLDKIYHAAFVLKDVARKTDLIEAPKLSKDCQLYLKTENLQAT
                     GSFKVRGAYYKISQLSEEESAKGVIACSAGNHAQGVALAATRRGIRSIVCMPDGAPLMK
                     VENTKNLGAEVCLVPGTYDEAHDKAVQLQKEYDMTFIHPYDDEQVIAGQGTIGLEILDQ
                     LPDVDAVVVPVGGGGLISGIAFAIKTLRPEVKVYGVQAEGAPSMYRSLHEHKYQTLKSA
                     STFADGIQVKTPGELTYQLCEQYVDDIVTVTEDETAAAILSLMENQKLVAEGAGAVPVA
                     AVLFHKLPVEGKKVACVISGGNIDVNILNRVITRGLVMSGRKANLTIALEDKPGQLKKV
                     AEVVSRCGSNVVSVQHDGSDPNMPISSCFLKLTLETRDAAQIEQIRTELTKAGFQLVTE
                     RV"
     CDS             2256..2630
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Ribonuc_L-PSP"
                     /gene_functions="regulatory (smcogs)
                     SMCOG1038:Endoribonuclease L-PSP (Score: 150.2; E-value:
                     8.5e-47)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg217_3"
                     /sec_met_domain="Ribonuc_L-PSP (E-value: 1.2e-47, bitscore:
                     150.2, seeds: 29, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKVVSTANAPAAIGPYSQALDLGNMVFVSGQIPVDPATGTMADTV
                     EQQAAQSLANLKAILAEAGLSMNNVVKTVIFLADINDFAAVNAEYAKAFAEPFPARSCV
                     QVAAIPKGAKLEIECIAVRD"
     CDS             complement(2718..3935)
                     /locus_tag="ctg217_4"
                     /transl_table=11
                     /translation="MKLREWNAHLHGLVVFRALLNDPVVAKLLDLTDRMEAGSSSYGPV
                     CDAVAAFEAALFEYTTNWGSYLSSAVLEAETICVRQAAAGQLDALLQSALDSELQFLQQ
                     LCGLTLDELFQTAYSEQAQRPELAFLPRWQTCELDLAAAYAQRMSEVGKKGYGMFAKHH
                     VFTVENGQLVPVKYPDPQRLSELPGYEKEREKVIANTKALLAGMPANNVLLYGDAGTGK
                     SSAVKAIANEFAPEGLRLVEVKKNQLYQIPDLMDKLAANPLKFILFIDDLSFTANDDNF
                     AALKAILEGSVGGRAQNIAVYATSNRRHLIKETLSDRTGDDIHEADTRQELMSLSARFG
                     LTVTFQRPEKARFETILEQLAKQHNIQMPTEQLLLKAEAFALRAGGRSPRVAKQFIEQC
                     EAGVQK"
     CDS             4462..6126
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg217_5"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.5e-51, bitscore:
                     163.5, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQLNGSQIFVEVLCEQGVDTLFGYPGGAVLNLYDELYKNADRITH
                     VLTAHEQGAAHAADGYARATGRTGVVLATSGPGATNLVTGIATAYMDSVPMVAFTGNVP
                     TSSIGKDGFQEAYIEGITVPITKHNFTVRRVEDLADTMRAAFRIAQSGRKGPVLVDIPK
                     DVTAAVCEFTPKQPEPIRTVTTYNEEQVHWAADLINAAQRPLVYFGGGVRSAASCQPLR
                     DLLHKAEIPATYTLMAAGVVPYGDPMNLGMLGMHGCYTSNRAVAECDVLIAVGTRFSDR
                     VALNPKTFAKNATIIQIDIDASELGKNVDVDLSIVGDAAYVLNAMLPQIKPAKHPDWMT
                     MIQSWQAQDYHPVSDPTRLMPHQVIGEVCNQCGPDAVYVTDVGQHQMWAAQYLRHTKSR
                     GFITSGGLGTMGFGYGAAIGAQMALGRQQRVVMFTGDASFHMNLNEACTAVSYELPIIT
                     VIFNNSVLGMVRQWQTSFYGKRYSQTDPHRKTDFVKLADGFGLKGYRCTNLPEFQEAFA
                     DALQQKGPTWIECIIDKDEKVLPMIPGGGDINDIIME"
     CDS             6142..6705
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg217_6"
                     /sec_met_domain="ALS_ss_C (E-value: 1.2e-28, bitscore:
                     88.6, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKSDQRRVISLLVDNQSGVLARVSSLFCRRGFNIDSLTVSATNDP
                     AVSRITVTITSDEKALQQLVLQTERLEVTRQVFVLDSEKALERELLLLKVESDVHNRTE
                     LREIACIYKAKIIDLSPDSMVFELIGRPDKLDAFLKMFEGYNILEQCRTGVTALERGGM
                     HQHIQKPPQEVRSVQLPPPGARRA"
     CDS             6804..7823
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg217_7"
                     /sec_met_domain="IlvN (E-value: 4.6e-75, bitscore: 240.0,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 6.7e-66, bitscore: 210.3,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAIKKYYDSDCNLGVLDGKTVAVIGFGSQGHAHSENLAESGVNVV
                     VGLRKGSAHWAKASEFAATHDNFKVMEVEEAAKAGDVVMMLVPDELCADIYNTQVAPYM
                     TEGKALAFAHGFNIHFKTITAPKNVDVIMIAPKGPGHIVRRLYTEGEGCPSLICVEQDY
                     TGKAKDIALAYASGIGAGRAGILQTTFKEETETDLFGEQAVLCGGVSELIHAGFDTLVE
                     AGYEPEMAYFETCHEMKLIVDLINEGGFSKMRYSISNTAEYGDYRTGKRLITEETRKEM
                     KKVLTEIQDGTFASEFLTEMSPKGGRKVHFLAKRRMEAELPIEKVGAELRSMMSWLKK"
     CDS             7989..9647
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ILVD_EDD"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg217_8"
                     /sec_met_domain="ILVD_EDD (E-value: 1.2e-223, bitscore:
                     732.5, seeds: 918, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRSDNVTKGSERAPNRSLFYALGYTPEELERPLIGVVSAYSEIVP
                     GHMNLDKIAEAVKAGVQMAGGTPILIPAIGVCDGIAMGHVDMKYSLASRELICDSVETM
                     LMAHQLDGLVLVPNCDKIVPGMVMAAVRMDVPAVVCSGGPMLAGTYGGEEVSLSKMFEA
                     VGAYKAGMITDEQLEDCTCNCCPSCGSCSGMYTANSMNCLCEAIGIALPGNGTIPAVYS
                     KRLQLAKHAGMAVMEMVRKGITARQIINERSIRNALTCDMALGCSTNTVLHLLAIAYEA
                     GVPIDLKLFNEISAKTPNLCHLAPAGPTHMPDLYAAGGIPAVQAELAKKGLLDLDVPTV
                     TGKTLGENIKGAHILNEKAIRPIENPYSETGGLQILWGNIAPDGCVVKRSAVAPEMQQH
                     SGPARVFNSEEEAIAAIYAGKIVPGDVVVIRYEGPKGGPGMREMLNPTSALAGMKLDKT
                     VALITDGRFSGASRGAAIGHVSPEAASGGPIGLIEEGDTISIDIPNASITLEVSDAVLA
                     ERKAKYVAPEPNIKTGWLSRYARMVTSANLGAVLK"
     CDS             complement(9684..10355)
                     /locus_tag="ctg217_9"
                     /transl_table=11
                     /translation="MESTISAAPQISIDREKTLRSHRRYWVLRRAQDIVFSLLALILLA
                     PLALLISLAIVLDSPGDGAIFRQRRVGRDGKLFWLYKFRTMCPDAEEQLNELLSQNQMD
                     GPVFKIKGDPRITRVGRFLRKTSLDELPQLLNVLQGDMSIVGPRPALPREVELYSDYQR
                     QRLYVTPGLSCYWQIAPHRNEMSFDEWVALDMKYIQERSFWVDWKIIFLTVRAMLMKYG
                     E"
ORIGIN
        1 ctgcagcggc gcgcagatcg gtgtactgac agtagaatac acaggcaatg attccacaga
       61 ggattacgcc acacaggctt tcaacgcgtg gggcatcggt tcgtcctcta agaacaacgg
      121 cgttctgatt ttgctggtga tggaatcggc gcagtatgcg gacggcgact actacctgac
      181 ctacggcgac ggtttccgca acaccacgct ggcaaaacag tccagcgcca tcgcccagac
      241 gatgaaggat cagtttgccg caaagaatta tgacggcgca gtgaccacct gtgcccgcaa
      301 cgtggcaaac accatcgcgg atatttacgg agtcagcctt tccggcggca acggcagcac
      361 cgtgcagccc ggctatcagg gcgggcagag cagcggcggc agcaccctga ccgacatcct
      421 gactcttgtg gtcagcgttg tgctgcttat cgtcattatc cggtcgatgg cctatgtttt
      481 tgccagtccc tgcggctggc tgtggtgctt cggtgggccg cggcctcccc gtggacggcg
      541 gcgcggcccg cataacccgc ccccgccggg cggcttctac ggcggctttg gcggcatggg
      601 cggcggctcc ttcgggggcg gtgccgggcg cggcggtttc ggcggcggca gctttggcgg
      661 cggcttcggt ggcatgggca gcggttccag ccatggcggc ggtggtggcc gtgggcggta
      721 atgagaataa aaagagaaag gcggtggctt taccactgcc tttctctttt ttacgccttt
      781 tatcgtgaat ggaattcatt tgacaaaaca atttttgtaa cttatactgg atgacatcac
      841 gaaaaataaa ggaagtatct gtcatgctga ctctggataa gatctaccac gccgcctttg
      901 tgctgaagga tgtagcgcgc aagaccgacc tcatcgaagc ccccaagctg tccaaggact
      961 gccagctgta ccttaagacc gagaacctgc aggccaccgg cagctttaag gtgcggggcg
     1021 cttactataa aatcagccag ctttctgagg aggagagcgc caagggcgtg attgcctgct
     1081 ctgcgggcaa ccatgcgcag ggggtggcgc tggccgctac ccggcgcggc atccgcagca
     1141 tcgtctgtat gccggacggc gcacccctga tgaaggtgga aaacaccaaa aatctgggcg
     1201 cggaggtctg tcttgtgccc ggcacctacg acgaagccca cgacaaggcc gtgcagctgc
     1261 aaaaggagta cgacatgacc tttatccacc cctacgatga cgagcaggtc atcgccgggc
     1321 agggaaccat cggcttggag atccttgacc agctgccgga tgtggacgct gtggtggtgc
     1381 cggtgggcgg cggcggactg atctccggca ttgcctttgc catcaagacc ctgcgcccgg
     1441 aggtcaaggt gtacggcgta caggccgagg gtgcccccag tatgtaccgc agcctgcacg
     1501 agcacaagta ccagaccctg aaatctgctt ccacctttgc ggacggtatt caggtcaaga
     1561 ccccgggcga gctgacctat cagctatgcg agcagtatgt ggacgatatc gttaccgtga
     1621 ccgaggacga gacggcggcg gccattctct ccctgatgga gaaccagaag ctggtggctg
     1681 agggtgcagg cgctgtgccg gtggcagcag tactgttcca caagctgccg gtggagggca
     1741 aaaaggtggc ctgcgtcatc tccggcggca acattgatgt gaacatcctg aaccgcgtca
     1801 ttacccgcgg tcttgtgatg agcggccgca aggcaaacct gaccatcgcg ctggaggaca
     1861 agcccggcca gctgaaaaag gtggccgagg tggtatcccg ctgcggcagc aatgtggtgt
     1921 cggtgcagca tgacggctcc gaccccaata tgcccatctc cagctgcttc ctcaagctga
     1981 cgctggagac ccgcgatgcc gcccagatcg agcagatccg caccgagctg accaaggccg
     2041 gtttccagct ggtcaccgag cgggtgtaaa cttcatcgtt tgcaagagtg aaagccttcc
     2101 cccggacggg gaaggtggat gcgaacgtag tgagcagacg gatgagggcg caggcaagca
     2161 gcagcttacg ggaaattacc ccctcgtctg gctctatccg aagaaaaaag cgaatttgtt
     2221 ctaaacttga tgtaatataa aggagaaaat atactatgaa agtcgtatct accgccaacg
     2281 cacctgccgc catcggccct tacagtcagg cactggatct gggcaacatg gtgtttgttt
     2341 ccgggcagat cccggtagac cccgccaccg gcaccatggc cgataccgtg gagcagcagg
     2401 ccgcccagag ccttgctaac ctgaaggcga ttctggccga ggcggggctt tccatgaaca
     2461 acgtggtcaa gacggtgatc tttctggccg atatcaacga ttttgccgca gtgaacgcag
     2521 agtacgccaa ggcctttgcc gagccgttcc ccgcccgcag ctgcgtgcag gtggcagcca
     2581 tccccaaggg tgcaaagctg gagatcgagt gcatcgccgt gcgggactga gcgagtaaag
     2641 acaagaaaag cgggacaccg gagcatctgc ggatgctttg gtgtcccgct ttttgataac
     2701 atttaaaact ggtgcgttta cttctgcaca ccggcctcgc attgctcgat gaattgcttg
     2761 gccacccggg ggctgcggcc gccggcacgc agggcaaagg cctcggcctt gagcagcagc
     2821 tgctcggtgg gcatctgaat gttgtgctgc ttggcaagct gctccagaat ggtctcgaac
     2881 cgtgcctttt ccggccgctg gaaggtgacc gtcaggccga accgggcgga aaggctcatc
     2941 agctcctgcc gggtgtcggc ttcatggatg tcgtcgccgg tgcggtctga gagagtctcc
     3001 ttgatgaggt ggcggcggtt ggaggtggcg tacaccgcaa tgttctgggc acggccgcct
     3061 acgctgccct ccaaaatggc cttcagggcg gcaaagttgt cgtcgttggc ggtaaagctc
     3121 aggtcgtcga tgaacaaaat gaacttgagc gggtttgccg ccagcttatc catcaggtcg
     3181 gggatctggt acagctggtt cttttttacc tctaccagcc gcagtccctc gggcgcaaac
     3241 tcgttggcaa tggcctttac cgcgctggat ttgccggtac cggcgtcacc gtacagcagc
     3301 acattgttgg cgggcatccc ggctagcagt gcctttgtgt tggcaatcac cttttcccgc
     3361 tccttctcgt agcctggcag ctcggaaagg cgctgcgggt cggggtattt taccggcaca
     3421 agctggccgt tctccaccgt gaatacatgg tgctttgcaa acataccgta gccctttttg
     3481 cccacctcgc tcatgcgctg ggcgtaggcg gcggcaaggt caagctcaca ggtctgccac
     3541 cggggcagga acgccaactc cggccgctgc gcctgctccg agtaggcggt ctggaacagt
     3601 tcgtccagcg tcagcccgca cagctgctgc aaaaactgca gctcgctgtc caaggcgctt
     3661 tgcagcagcg cgtccagctg cccggcagcg gcctgccgca cgcagatggt ctcggcctcc
     3721 agcacggcgc tgctcaggta gctgccccag ttggtggtgt actcgaacaa agcggcctca
     3781 aaggcggcta cggcatcgca caccgggccg taggaggagc tgccggcctc catgcggtcg
     3841 gtcaggtcta aaagctttgc cacaacaggg tcgttcagca gggcgcggaa cacaacaagc
     3901 ccatgcagat gggcattcca ttctctcagt ttcataggtc gatccctttt cctctccatt
     3961 ggcacatacc ctacaaaacg caggtacgcg gatatcaaaa gtatacagcg gttcaggctt
     4021 ggatgcaagg ggtgttaaaa atgcttcatc tttcgggtga ttcaggttac aaattgtcga
     4081 ttgacaaaag cccggtttat agtataattt acatcaacaa atgcgcagat gggaaaaagt
     4141 accacacgat ccccactgtt cagagagctg ccgtctggtg caaggcagtc agcgtttcgt
     4201 gcggaaaatc atcccggagc agcctgccca acgggtgcaa aacccttgta agcagcgccg
     4261 gttgcagccg ttaccgtgca gggctttgtt ggaagcccgt gagagggtgt gcacagcacg
     4321 ccaacgagag tggtaccgca gagagcttga tgttacaagg tctttgtctc ttgaagaaag
     4381 caggggacaa gggctttttc tttttcaaaa gctctccctg agggaatgga taagaagtgg
     4441 aacaggaata ggagcaacac catgcagttg aatggttctc agatctttgt agaggtcctg
     4501 tgcgagcagg gagtggacac tctttttggc taccccggcg gcgctgtgct gaacctttac
     4561 gacgagctgt ataagaatgc cgaccgcatc acccatgtgc ttaccgccca cgagcagggc
     4621 gcagcccatg cagcggacgg ctacgcccgc gccaccggcc gcaccggcgt ggtgctggcc
     4681 accagcggcc cgggtgccac caatctggtc accggcattg ccaccgccta tatggactcg
     4741 gtgcccatgg tggcctttac cggcaacgtg cccaccagca gtatcggcaa ggacggcttt
     4801 caggaagcgt acatcgaggg catcaccgtg cccatcacaa agcataattt cacggtgcgc
     4861 cgggtagagg acttggctga caccatgcgg gcggccttcc gcattgcgca gagcggccgc
     4921 aagggcccgg tgctggtgga catccccaag gacgtgaccg cagcggtgtg cgagttcacc
     4981 cccaagcagc cggagcccat ccgcaccgta actacctata atgaggagca ggtgcactgg
     5041 gcggcagacc tcatcaacgc cgcacagcgt ccgctggtgt actttggcgg cggcgtgcgc
     5101 agcgcagcca gctgccagcc gttgcgggat ctgctgcaca aggcggagat ccctgctacc
     5161 tacaccctga tggcggcagg cgttgtgccc tacggcgacc cgatgaatct ggggatgctg
     5221 gggatgcacg gctgctacac ctccaaccgg gcggtggcag agtgcgatgt gctcatcgcg
     5281 gtgggtaccc gcttctccga ccgtgtggcg ctgaacccca agacctttgc caaaaacgcc
     5341 accatcatcc agatcgacat tgacgccagc gagctgggca agaacgtgga cgtggatctt
     5401 tccatcgtgg gcgatgcagc ctatgtgctg aacgccatgc tgccccagat caagcccgcc
     5461 aagcacccgg actggatgac gatgatccag agctggcagg cacaggatta ccaccctgtg
     5521 tccgacccca cccggctgat gccccatcag gtcatcggcg aggtgtgcaa ccagtgcggc
     5581 cccgacgccg tgtatgttac cgacgtgggt cagcaccaga tgtgggcggc gcagtacctg
     5641 cgccacacca agagccgcgg ctttatcacc agcggcggcc ttggcaccat gggctttggc
     5701 tacggcgctg ccattggtgc ccagatggca ctgggacgcc agcagcgtgt ggtgatgttt
     5761 accggcgacg cctccttcca catgaacctg aacgaagcct gcaccgccgt cagctacgag
     5821 ctgcccatca tcacggtcat cttcaataac tcggtgctgg gcatggtacg ccagtggcag
     5881 accagctttt acggcaagcg ttacagccag accgaccccc accgcaagac cgattttgtc
     5941 aagctggcag acggctttgg cctgaagggc taccgctgca ccaatctgcc ggagtttcag
     6001 gaagcctttg cagatgccct gcagcagaaa ggccccacct ggatcgagtg catcattgac
     6061 aaggacgaaa aggtgctgcc catgatcccc ggcggcggcg atatcaacga catcatcatg
     6121 gaataaggag gacacagcat catgaaatct gatcagcgca gggtcatcag cctgctggtg
     6181 gacaaccaga gcggcgttct ggcccgggtg tccagcctgt tctgccgccg cggcttcaat
     6241 atcgacagcc ttacggtgtc cgccaccaac gacccggcag tcagccgcat cacagtgacc
     6301 attaccagcg atgaaaaggc cttgcagcag ctggtattgc agaccgagcg gctggaagtc
     6361 acccggcagg tgttcgtgct ggacagcgaa aaagcgctgg agcgggagct gctgctgctc
     6421 aaggtggaat cggacgtgca caaccgcaca gagctgcggg agatcgcctg catctacaag
     6481 gcaaagatca tcgatctttc cccggacagc atggtgtttg agttgatcgg ccggccggac
     6541 aagctggacg catttttgaa aatgttcgag ggctacaaca tccttgagca gtgccgcacc
     6601 ggcgttactg cactggagcg cggcgggatg caccagcata tccagaagcc gccgcaggag
     6661 gtgcgctccg tccagctgcc cccgccgggc gcaagacggg cataattaca ttgcttttcc
     6721 gctcagggtg agcgaaagat agaacagagc atacaagacc ggaagataaa ccaaccagtt
     6781 aatgtaaaag gagactaacg attatggcta tcaagaaata ctacgattcc gactgcaacc
     6841 tcggcgtgct ggacggcaag accgtcgctg tcatcggctt cggcagccag ggtcatgcac
     6901 actctgagaa tctggctgag agcggcgtca acgttgtggt cggcctgcgc aagggttctg
     6961 ctcactgggc aaaggcttct gagttcgctg ccacccatga caacttcaag gtcatggagg
     7021 tggaagaggc tgccaaggcc ggcgatgttg tcatgatgct ggtgcccgat gagctgtgcg
     7081 ccgatatcta caacacccag gttgctccct acatgaccga gggcaaggca ctggcctttg
     7141 cacacggctt caacatccac ttcaagacca tcaccgctcc caagaacgtg gacgtcatca
     7201 tgatcgctcc caagggcccc ggccacatcg tgcgccgcct gtacaccgag ggcgagggct
     7261 gcccctctct gatctgcgtg gagcaggact acaccggtaa ggccaaggat atcgcactgg
     7321 cttatgcttc cggcatcggc gcaggccgtg caggcattct gcagaccacc ttcaaggagg
     7381 agaccgagac cgatctgttc ggcgagcagg ccgtgctgtg cggcggtgtt tccgagctga
     7441 tccacgccgg cttcgatacg ctggtggagg ccggctacga gcccgagatg gcctactttg
     7501 agacctgcca cgagatgaag ctgatcgttg acctgatcaa cgagggcggc ttctccaaga
     7561 tgcgctactc catctccaac actgccgagt acggcgacta ccgcaccggc aagcgcctga
     7621 ttaccgagga gacccgcaag gagatgaaga aggttctgac cgagatccag gacggcacct
     7681 ttgcttctga gttcctgacc gagatgagcc ccaagggcgg ccgcaaggtg cacttccttg
     7741 ccaagcgccg catggaggct gagctgccca tcgagaaggt gggtgctgag ctgcgcagca
     7801 tgatgagctg gctgaagaag taagaggaga accctctcag accgcttttc ggcggtcagc
     7861 tcccccgaaa gggggagttt ttgttgaaaa gggaacctta tagctcctcc gcgaaacctc
     7921 tccctctcgg gagaggtggc acggcgcaac cgtgacggag agggctttat cagaaaagag
     7981 gatttgcaat gagaagtgac aacgtgacca agggctcgga gcgcgcgccc aaccgcagcc
     8041 tgttttatgc gctgggctac accccggagg aactggagcg ccccctcatc ggcgtggtga
     8101 gcgcctacag cgagatcgtg cccggacaca tgaatctgga taagatcgcc gaggctgtca
     8161 aggccggtgt gcagatggcc ggtggtaccc ccatcctgat ccccgccatc ggtgtatgcg
     8221 atggcatcgc tatgggtcat gtggacatga agtactcttt ggcctcccgt gaactgatct
     8281 gcgacagcgt ggagaccatg ctgatggcac accagctgga cggccttgtg ctggtgccca
     8341 actgcgataa gatcgtgccc ggcatggtga tggcagcggt gcgcatggat gtgcccgctg
     8401 tggtctgctc cggcggtccc atgctggccg gtacttacgg cggcgaggaa gtgagccttt
     8461 ccaagatgtt cgaggccgtg ggtgcctata aggccggtat gatcaccgac gagcagctgg
     8521 aggactgcac ctgcaactgc tgtcccagct gcggcagctg ctccggtatg tacaccgcca
     8581 acagcatgaa ctgcctgtgc gaggccatcg gcattgccct gcccggcaac ggcaccatcc
     8641 cggctgtgta ctccaagcgt ctgcagctgg caaagcacgc cggtatggct gtgatggaga
     8701 tggtgcgcaa gggcatcacc gcgcgccaga tcatcaacga gcgctccatc cgcaacgcac
     8761 tgacctgtga tatggcgctg ggctgctcca ccaacacggt gctgcacctg ctggctatcg
     8821 cctacgaggc cggtgtgcct atcgacctga agctgttcaa cgagatcagc gccaagaccc
     8881 ccaacctgtg ccatctggca ccggcaggtc ccacccatat gccggatctg tacgcagcgg
     8941 gcggcatccc ggcagtacag gcggagctgg ccaagaaggg cctgctggat ctggatgtgc
     9001 ccaccgtcac cggcaagacc cttggcgaga atatcaaggg tgcccatatc ctgaacgaaa
     9061 aggccatccg tcccatcgag aacccctact ctgagaccgg cggtctgcag atcctgtggg
     9121 gcaacattgc cccggacggc tgtgtggtca agcgcagcgc tgtcgccccg gagatgcagc
     9181 agcattccgg cccggcgcgg gtgttcaaca gcgaggagga ggccattgcc gccatctacg
     9241 cgggcaagat cgtcccgggc gatgtggtgg tcatccgcta cgaaggcccc aagggcggcc
     9301 cgggcatgcg ggagatgctc aaccccacct ctgcgctggc aggcatgaag ctggataaga
     9361 cggtggccct catcaccgac ggccgcttct ccggcgcatc ccgcggtgct gccatcggcc
     9421 atgtcagccc ggaggcggcc tccggcggcc ccatcggcct gatcgaagaa ggggatacca
     9481 tttccattga tatccccaac gcctccatca cgctggaggt cagcgatgca gtgctggccg
     9541 agcgcaaggc aaagtacgtt gcgcccgagc ccaacatcaa gaccggctgg ctgagccgtt
     9601 acgcccgcat ggtcaccagt gcaaatctgg gtgcagtgct gaaataaacg taacgaaagc
     9661 gccttgcaca acaggcgctt ttgtcactct ccgtatttca tgagcatggc gcggacggtg
     9721 aggaagatga tcttccagtc cacccagaag ctgcgctcct ggatgtattt catatccagc
     9781 gccacccact cgtcaaagct catctcgtta cggtggggtg cgatttgcca gtagcagctc
     9841 agtccggggg tgacgtacag ccgctggcgc tggtagtcgc tgtacagctc tacctcccgg
     9901 ggcagtgcgg ggcgcggccc cacgatgctc atatcgccct gcagcacgtt gagcagctgt
     9961 ggcagctcgt ccagactggt cttgcgcaga aaacgtccca cccgggtaat gcgggggtcg
    10021 cccttgatct tgaacaccgg gccgtccatc tggttctggc tcagcagctc attcagctgc
    10081 tcctcggcgt ccgggcacat ggtacgaaac ttatacagcc agaacagctt gccgtcccgt
    10141 cctacccgcc gctgccggaa aatagctccg tctccggggc tgtccagcac gatggcaagg
    10201 ctgatcagca gtgccagcgg cgcaagcagg atcagcgcca gcagggagaa tacgatgtcc
    10261 tgtgcacgcc gcagcaccca gtaacgccgg tggctgcgca gcgtcttttc ccggtcgata
    10321 gaaatttgcg gggcggcgct gattgttgac tccatgcaat gacccactcc tgcctgtaaa
    10381 atgtgtagaa tctttacatt attttaacat aaaacaggac gcaattcaac cggatgaagc
    10441 gcggcgggcg ggggacagta agcctgctga aaaaaagtga aaaaaggtgg ttgacaaaac
    10501 ccttttctca tgctaaaata aacaagtcgt ccggcgcacg gatgcacaac aactgaatat
    10561 gggcgtgttc ccgagtggcc aatggggaca gactgtaaat ctgctgcttt cagcttcggt
    10621 ggttcgaatc cacccgcgcc caccaaaaag cctcagcgta tgcgagtacg ctgaggtttt
    10681 tgttttgtaa caaggctaaa cttatagggc gggtggattc gaacagcaac agcgacgacc
    10741 gctgccagcg gcagaaacag ggaggagctg ttggggctgc ggccagcagg atgcgcgtgc
    10801 cgcccaaggc acgatgcagc cgctgggagc cgcgacccgg gttccttttc tgcgcggctc
    10861 gcgacatcca cccgcgccca ccaa
//
