LOCUS       c00015_gnlPro..        15366 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|GOCEDJGG_15.
ACCESSION   c00015_gnlPro..
VERSION     c00015_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 00:19:53
            Original ID  :: gnl|Prokka|GOCEDJGG_15
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15366
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15366
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2502:7793]"
                     /cutoff="10000"
                     /detection_rule="(not (POR or POR_N or PFOR_II) and
                     minimum(4, [Acyl-CoA_dh_1, Acyl-CoA_dh_2, ECH_2, ETF,
                     ETF_alpha, HCDH_N, Thiolase_N, ketoacyl-synt]) and HCDH and
                     minimum(1, [EC1_2-faecali, ECH1_Enoyl_CoA_DH1,
                     ECH1_Enoyl_CoA_DH2, ECH1_Enoyl_CoA_DH3, ECH1_Enoyl_CoA_DH4,
                     Thiolase_C]))"
                     /neighbourhood="10000"
                     /product="acetate2butyrate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      2503..7793
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(not (POR or POR_N or PFOR_II) and
                     minimum(4, [Acyl-CoA_dh_1, Acyl-CoA_dh_2, ECH_2, ETF,
                     ETF_alpha, HCDH_N, Thiolase_N, ketoacyl-synt]) and HCDH and
                     minimum(1, [EC1_2-faecali, ECH1_Enoyl_CoA_DH1,
                     ECH1_Enoyl_CoA_DH2, ECH1_Enoyl_CoA_DH3, ECH1_Enoyl_CoA_DH4,
                     Thiolase_C]))"
                     /neighbourhood="10000"
                     /product="acetate2butyrate"
                     /protocluster_number="1"
     cand_cluster    1..15366
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(not (POR or POR_N or PFOR_II) and
                     minimum(4, [Acyl-CoA_dh_1, Acyl-CoA_dh_2, ECH_2, ETF,
                     ETF_alpha, HCDH_N, Thiolase_N, ketoacyl-synt]) and HCDH and
                     minimum(1, [EC1_2-faecali, ECH1_Enoyl_CoA_DH1,
                     ECH1_Enoyl_CoA_DH2, ECH1_Enoyl_CoA_DH3, ECH1_Enoyl_CoA_DH4,
                     Thiolase_C]))"
                     /kind="single"
                     /product="acetate2butyrate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15366
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="acetate2butyrate"
                     /region_number="1"
                     /rules="(not (POR or POR_N or PFOR_II) and minimum(4,
                     [Acyl-CoA_dh_1, Acyl-CoA_dh_2, ECH_2, ETF, ETF_alpha,
                     HCDH_N, Thiolase_N, ketoacyl-synt]) and HCDH and minimum(1,
                     [EC1_2-faecali, ECH1_Enoyl_CoA_DH1, ECH1_Enoyl_CoA_DH2,
                     ECH1_Enoyl_CoA_DH3, ECH1_Enoyl_CoA_DH4, Thiolase_C]))"
                     /tool="gutsmash"
     CDS             complement(313..903)
                     /locus_tag="ctg15_1"
                     /transl_table=11
                     /translation="MTKSKFSTKYLVEMALLVAIILLMAFTPIGYIKTAGLEITLIVIP
                     VAVGAVTLGPAAGAILGGVFGITSFIQCFGMSAFGTLLLGVNPVFTFLVCVPTRILDGW
                     LTGLIYAGLKKTKIPSAGSVTLASLCCPLLNTTFFMGTLVTLFAGTMREQFGMTKVIPF
                     IAAFVGVNGVVEAIVCFVIGTAVSMALKKALRY"
     CDS             complement(998..2362)
                     /locus_tag="ctg15_2"
                     /transl_table=11
                     /translation="VRQTVTENRLFSKKDLRKLIIPLILEQTLAITVGMADTMMISSAG
                     EAAVSGVSLVDMFNNLIISVLAALATGGAVVTSQCIGAGRREEACRSARQLVFTEAAIT
                     IGISVLVLLFHRQILGLFFGQIEADVMQNAIIYLIISVFSFPLLAVYDSCAALYRSMGN
                     AQITLKISLLMNVINVVGNAIGVYVLKLGVAGVAIPSLVSRGVAGVVLFTFLHNPDNLV
                     FLTRGKFKVDATIVKRILFIGIPSGIENGIFQLGRVLVVSIIAAFGTSQIAANGVANSL
                     DSMGCIVGQAMSLAMITVIGRCVGAGEEGQVRYYTKKLLGETYFYTAVINSIILLLLPW
                     ILQIYGLGEETTRLSYILVMIHDGMAIFLWPASFVLPNMLRACNDVKYTMVVSIFSMIT
                     FRIGFSYLFGVHMGWMAVGVWAAMVIDWVFRVLCFVGRYLAGTWRKKCGLVAPTA"
     CDS             complement(2503..3543)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: ETF_alpha"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: ETF"
                     /gene_functions="electron_transport (smcogs)
                     SMCOG1008:Electron-transferring flavoprotein (Score: 163.8;
                     E-value: 1.3e-50)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg15_3"
                     /sec_met_domain="ETF (E-value: 2.8e-51, bitscore: 163.8,
                     seeds: 129, tool: rule-based-clusters)"
                     /sec_met_domain="ETF_alpha (E-value: 8.8e-39, bitscore:
                     121.4, seeds: 511, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGLEEYKGVFVFAQQVDNVLDGVAFELLGKGKELAKDLNTEVTAV
                     LIGSGVKELADQLAEYGADRVIVVDDPQLKDYRTEPYAHALASVINEYKPEIMLVGATA
                     IGRDLGPTVSARVKTGLTADCTMLEIGDFPLNAAPGQEQQHNQLLMTRPAFGGNTIATI
                     ACPYNRPQMATVRPGVMQKIAPIAGAKANVVEYNPGFTPNDRYVEILNIVKAVKNTANI
                     MDAKILVSGGRGVGSKENFKLLEDLAEVLGGTVSCSRAVVENGWLPVDLQVGQTGKTVR
                     PQIYFAIGISGAIQHVAGMEDSDLIVAINKDEDAPIFDVADYGLVGDLNKIVPALTTAL
                     KAELGK"
     CDS             complement(3571..4353)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: ETF"
                     /gene_functions="electron_transport (smcogs)
                     SMCOG1008:Electron-transferring flavoprotein (Score: 158.7;
                     E-value: 4.7e-49)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg15_4"
                     /sec_met_domain="ETF (E-value: 9.8e-50, bitscore: 158.7,
                     seeds: 129, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNIVVCIKQVPDTKGGVKFNPDGTLDRAAMLTIMNPDDKAGLEAA
                     LRLKEQYGAEVTVLTMGLPKADEVLREAMAMGADKGILVTDRVLGGADTWATSTTIAGA
                     LRNLDYDLIITGRQAIDGDTAQVGPQIAEHLGLPVISYAQDIKIDGEYVVVQRQYEDRY
                     HELKAKMPCLITALSELNQPRYMTPGGIFDAYDKEVTVWGRADLKDVDDSDLGLKGSPT
                     KIAKASDKVRKGAGEKVVLDPDESVAYLIGKFKEKHII"
     CDS             complement(4399..5553)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg15_5"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 6.1e-53, bitscore:
                     168.9, seeds: 49, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 2.5e-31, bitscore:
                     97.7, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 8.9e-41, bitscore:
                     129.0, seeds: 796, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDFTLDKKHEMARSLFREFAENEVKPLAQEVDETEEFPVENVKKM
                     QKLGFMGIPVPKEYGGQGCDPLTYVMCVEELSKVCATTGVVVSAHTSLCIDPIMTYGTE
                     DQKQKYVKPLATGEKLGAFALTEPGAGTDAQGAQTKAVLDGDEWVLNGSKCFITNGKVA
                     DVYIVIAITSVTEDKRGRKKKNFSAFIVDKGAPGFSFGTKEKKMGIRGSSTYELIFEDC
                     RIPKENLLGVEGKGFPIAMHTLDGGRIGIAAQALGIAEGALDRAIAYTKERKQFGRTIA
                     QQQNTQFKLADMAARIEAAQLLVYKAAMAKATQKVYSVEAAKAKLFAAETAMAVTTEVV
                     QLFGGYGYIREYDVERMMRDAKITEIYEGTSEVQRMVISGALLK"
     CDS             complement(5585..6457)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: HCDH_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: HCDH"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg15_6"
                     /sec_met_domain="HCDH (E-value: 2.2e-35, bitscore: 111.1,
                     seeds: 68, tool: rule-based-clusters)"
                     /sec_met_domain="HCDH_N (E-value: 1.2e-61, bitscore: 197.5,
                     seeds: 60, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKVGVIGAGTMGQGIAKAFAQVDGYEVALCDIKQEWADGGKEKIK
                     KGYARLVEKGKMTQEAVDGILAKITPGLKEDLCKDCDLIVEAAFEDMGVKKTTFQELDK
                     IAKPECIFASNTSSLSITEIGNGLTRPMVGMHFFNPADRMKLIEVIAGVNTPEETVEAI
                     KKISVEIGKTPVQVNEAAGFVVNRILIPMINEAAFIKMEGVSDIAGIDAAMKLGANHPM
                     GPLELGDFIGLDICLAIMDVLYKETGDSKYRACPLIRKMVRGGNLGAKSGKGFYVYNAD
                     RTKTPVDAQ"
     CDS             complement(6609..7793)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: Thiolase_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: Thiolase_N"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg15_7"
                     /sec_met_domain="Thiolase_N (E-value: 1.7e-98, bitscore:
                     318.8, seeds: 30, tool: rule-based-clusters)"
                     /sec_met_domain="Thiolase_C (E-value: 5.3e-52, bitscore:
                     164.5, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAKKVVLAGACRTAIGKMGGALSNTPAAELGSIVIKEALNRAGVK
                     PEQVDEVLMGCVIQAAQGQNVARQASIKAGLPIEVPAVTLNVVCGSGLKCVNEAATMIL
                     AGQADIVVAGGMENMSMAPYAMTKARFGYRMNNATIIDTMVNDALTDAFNHYHMMITAE
                     NVCEKYGLTREELDEFSANSQQKCEKAIAEGKFDDEIVPVPVKVKKETVMFAKDEGPRP
                     GTTAESLSKLKCCSGKEGGLVTAGNASGINDGAAAIVVMSEEKAKELGVKPMATWVAGA
                     LGGVEPEIMGVGPVASTRKVLERTGLTIDDMDLIEANEAFAAQSVAVARDLKFDMSKVN
                     VNGGAIALGHPVGASGCRILVTLLHEMQKRDAKRGLATLCIGGGMGCSTIVERD"
     CDS             complement(7814..7972)
                     /locus_tag="ctg15_8"
                     /transl_table=11
                     /translation="MHLVKKRGRNINFNCKVEFIFFSKKIVKKLTAFFGKIILKRNIFP
                     VHTGFCV"
     CDS             complement(8243..9460)
                     /locus_tag="ctg15_9"
                     /transl_table=11
                     /translation="MILLEPGFLKENPTFPEKEVLMIQIPWRRVAGAALVMCLLLANTS
                     YAETTQDNINDAKNQIEDLKDQKKDAEDTVNDISGKKDALESDLSGLNGQLSDIVAQIN
                     DLEGQISDKQGEIDQAKEDLAAAEAQSAKQYEDMKLRIQFMYENGSTPVWQMLAEAESF
                     SDFLNRTEYITDINAYDRKKLVEYQDLQEQIAAQKEDLESDMTELVAMQDDMKKKQANV
                     SSLINTTKANLAQTQEDLADAQSNVADLEDKINQMVEYEKQLEIQKAKEDAARLAAIKE
                     QEKEDTSTVVYVPTDSDQYLLGAIIQCEAGGESYDGKLAVGSVVINRVKSSYFPNSVSG
                     VIYQSGQFSPVVSGRLAYRLEAGVDGSCLQAAQDVLNGNITVGCLYFRQNNGIIQGTVI
                     GNHVFY"
     CDS             9522..10859
                     /locus_tag="ctg15_10"
                     /transl_table=11
                     /translation="MTIPEEGEIIMQFVKTADLKPGMRLAKPIYNRMGVLLYERDTRLT
                     IQGINSIENFGLIGIFILEPAEPLPPLSREDLEFEQFQTIYMFKLKDNMDKLVDNLVPS
                     TLLSLVDDIQRHYGSLDHKLNFTQTLRSSADFVYKHSISVGILSAMISNEMQLPAEDIR
                     ALITASLLYDFGYLYVPQAILDKGDDLSDSDRNFIQMNLERGYESIRPRYEECNLPKIS
                     LEIIQQFIFQKSQTLKIKDPSPETRLLCDILKVADQFDRLTAMNINNPPVSEVAAMSFL
                     RRHSRTYNPRVVAALAECIHILPTGACVDLSDGEKALVLVENAADFTRPMILKFSNNMI
                     YDLSDPVIGDSLRVTDIMKTMDNRIAIDEEALEHFVADQYIRETADRFRQKKLAIAQRK
                     QKAAQKKSMDDLLDNARVLTPPPIAPVPEEDASPIRKAPRKRMKLV"
     CDS             complement(10924..11793)
                     /locus_tag="ctg15_11"
                     /transl_table=11
                     /translation="MEEQKNKYENVTLEPDVGFDIRFVTMDHNSPFHWHREMEILYILN
                     GHATVHMEGEEYELNPLDAVVMDYARIHEVIYALPQTMGICIHVSRQLLRRYLPEAEPF
                     AIRCAGQRLRPGQQEYYNEICGYLKELTVLYVNQNETYRLKSTARILELLACLVEHFSE
                     PVSMVATQTRAGKMERLEQICMYVDHHYREEMTLQEAADELGLNREYFCRFFKQSTGTS
                     FMRYVNQVRLNYIYQDLLHTDDPVQEIMERHGFFNQKLFYRMFKERYHCTPRQARRMAE
                     NNPYVEAK"
     CDS             11898..12044
                     /locus_tag="ctg15_12"
                     /transl_table=11
                     /translation="MNKQKCTNSIKEEIIMLAKIKAFFMENIDGVAMGVEAMYGVDIHP
                     YYN"
     CDS             complement(12304..15366)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) CPSase_L_D2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg15_13"
                     /sec_met_domain="CPSase_L_D2 (E-value: 5.6e-84, bitscore:
                     270.6, seeds: 16, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="SNPATIMTDKDIADQVYIEPLTVPVLEQIIAKEKPDSILPTLGGQ
                     AGLNLGMELSEKGILDKYGVKLIGTTAETIFKAEDRQAFKDTMEKIGEPCAASEVVHNV
                     QDGIKFTNTIGYPVVLRPAYTLGGSGGGIAHDETELIEILTNGLRLSRVGEVLVERCIA
                     GWKEIEYEVMRDANGNCITVCNMENIDPVGVHTGDSIVVAPSQTLGDKEYQMLRTSALN
                     IISELNITGGCNVQYALNPESFEYCVIEVNPRVSRSSALASKATGYPIAKVAAKIALGY
                     TLDEIKNAITGKTYASFEPMLDYCVVKIPRLPFDKFITAKRTLTTQMKATGEVMSICNN
                     FEGALMKAIRSLEQHVDSLMSYDFTGLSREELVKQLHVVDDRRIWVIAEALRRGMDYDV
                     IHDITKIDKWFIDKLAILVEMEQKLKSEPLTVELLKEAKRIEFPDKVIAELTGKTETEI
                     HDMRYANGIVAAYKMVDTCAAEFEATTPYYYSVFGSENEAEETHPNKKVLVLGSGPIRI
                     GQGIEFDYCSVHCTWAFAKEGWETVIVNNNPETVSTDFDIADKLYFEPLTPEDVEAIVK
                     LEKPDGAVVQFGGQTAIKLTESLMKMGVKILGTKAEDVDAAEDRELFDEILEKTKIPRA
                     AGGTVFTAEEAKEVANRLGYPVLVRPSYVLGGQGMKIAFNDDEIEEFIGIINRIAQDHP
                     ILVDKYLQGKEIEVDAVCDGTDILIPGIMEHIERTGVHSGDSISVYPAPTISDHVKETI
                     VEYTKRLAQALHVIGLINIQFIAMNEEVYVIEVNPRSSRTVPYISKVTGIPIVDLATKV
                     IIGNTIRGLGYEPGLAPTADYIAIKMPVFSFEKLRGAEISLGPEMKSTGECLGIAKTFN
                     EALYKAFLGAGVTLPKYKQMIMTVKDADKPEAVGVAKRFEALGYKIYATRSTAKYLQEH
                     GVNALRVNKITQESPNVMDLILGHKIDLVIDTPTQGNGDKTRDGFLIRRNAIETGVYCI
                     TAMDTANALARSLETAMDTLTPVDIAKVKNL"
ORIGIN
        1 gtataaaacc gcgcgaaccg aaactcgccg gcatctgcta ttgaaaataa ggcagatgcc
       61 gactcagaca tcggcttcgc gcggttatgt tttgctcaga ggtgtcatta gggacacaca
      121 caaaagtcct acaaattgtc ttccgggatg cggacatgac ccgcggagta ctccaaactt
      181 ggaaagacac ggatcatcaa agatgcaaac attcggctgg ttagagatcc acattttttg
      241 aaccgaattt ccagctgcat ttccacatga aatccccaag tgtatttctt ctcgtaatat
      301 tacttattgt tcctagtagc ggagtgcttt tttcaatgcc atggaaaccg ctgttccgat
      361 aacgaaacat acaatcgcct cgacaacacc gttcacgccg acaaacgctg caataaacgg
      421 gatcactttc gtcatgccga actgctcacg cattgttcct gcgaacaggg ttaccagtgt
      481 tcccataaaa aatgtggtgt tcagcaacgg acagcaaagg ctggcaagcg ttaccgaacc
      541 tgcggaaggt attttcgtct tcttcagtcc cgcatagatc agtccggtca gccatccgtc
      601 cagaatacgt gtcggcacac ataccagaaa tgtgaatacc gggtttacgc ccagaaggag
      661 cgtaccaaac gcgctcattc caaaacactg gataaaactc gtgataccga acacaccgcc
      721 taagattgct cctgccgccg gtcccaatgt tacagctcct accgcaactg gtatgacaat
      781 cagggtaatc tcaagacctg ctgtctttat gtaaccaatc ggggtaaaag ccatgagtaa
      841 gatgatggca accaaaagcg ccatctccac gagatacttc gtagaaaatt tcgacttcgt
      901 catagtcttt tcctcttttc tgtatacttt gtttatggtt cctgtctgcc aggaactttt
      961 tgcatctttt gcagtatatc actatgtgaa atatttatca agcagttggc gccacaagac
     1021 cacatttttt ccgccaggtt cccgccagat atcttcccac aaaacagagt acgcggaaca
     1081 cccagtcaat taccatggca gcccacaccc cgactgccat ccatcccatg tgaacgccaa
     1141 acaggtagct gaaaccgatg cggaaggtaa tcatggaaaa aatcgacacg accatcgtgt
     1201 attttacatc gttgcaggcg cggagcatat tcggcagcac aaacgacgcc ggccacagga
     1261 agatcgccat tccatcatga atcatgacca gaatgtagga caggcgcgtc gtctcctctc
     1321 ccagtccata gatctgtaaa atccacggca gcagaagtaa aatgatgctg ttgatgaccg
     1381 ccgtataaaa ataggtctct cccagcagct ttttggtgta atagcgcacc tgtccttctt
     1441 ctccggctcc cacacaacgt ccgatcacag taatcatcgc aaggctcatc gcctgtccca
     1501 caatacatcc catggaatcc agactgttcg ccaccccgtt cgccgcgatc tggctggtgc
     1561 cgaacgcagc tatgatgctg accacaagca cacgtcccag ctggaagata ccgttttcaa
     1621 ttccgctcgg gatgccgata aaaagaatcc gcttcacaat cgttgcgtcc actttaaatt
     1681 ttcctctggt gagaaagacc agattgtccg gattatgcaa aaacgtaaaa agcaccactc
     1741 ctgccacacc gcgggaaacc aacgacggaa tggcgactcc cgctactccc agtttcagca
     1801 catacacgcc gattgcattt cccacaacgt tgatgacatt catcagcagc gatattttca
     1861 atgtgatctg cgcattcccc atcgaacggt acagcgccgc acacgagtca tacactgcga
     1921 gaagcggaaa tgagaacacg gagataatga gatagatgat cgcattctgc ataacatccg
     1981 cctcaatctg tccgaagaat aatccgagga tctgcctgtg aaaaagaagt accagtacac
     2041 tgataccgat cgtgatcgcc gcctctgtaa acacaagctg tctggcagac cggcaggctt
     2101 cctctctcct tcccgcaccg atacactgtg acgttaccac cgcaccgccg gtcgcaagcg
     2161 ccgccagcac actgatgatt aagttgttaa acatgtctac cagcgacacg ccggaaactg
     2221 ccgcttctcc cgcagaagaa atcatcatcg tatctgccat tcccacggtg atggcaagcg
     2281 tctgttctaa gatcagcgga ataatcagtt tccgcaaatc ttttttactg aataatcgat
     2341 tttctgttac tgtctgtctc acgttctttc actccttcgg aatgacaata atacgcaaaa
     2401 cggcaactgt caagctcgtg aaataaaaac ataaaaactc ccgcatgaca gacgccacat
     2461 ctgccacgcg ggagttcttt tcacctatgt acttttcttt gcttatttgc caagttctgc
     2521 ctttaacgca gtggtcagtg ccggaacgat cttgttgaga tctcctacca gaccataatc
     2581 tgcaacgtcg aagatcggtg catcctcatc cttgttgata gcaacgatga gatcagaatc
     2641 ctccatacct gcaacgtgct ggatagctcc tgaaataccg attgcgaagt agatctgcgg
     2701 acgtactgtc ttacctgtct gtcctacctg taaatctacc ggcagccagc cgttctccac
     2761 tacggcacgg gagcagctta cggtaccgcc aagtacctct gccagatcct cgagaagctt
     2821 gaagttctcc ttggaaccaa caccacgtcc accggatacc aggatctttg catccatgat
     2881 attcgctgta ttcttaacag cctttacaat gtttaagatc tctacatatc tgtcattcgg
     2941 ggtgaatccc ggattgtact ctaccacatt tgccttagcg cctgcaatcg gagcgatctt
     3001 ctgcataaca cctgggcgta cagtagccat ctgcggacgg ttgtacgggc acgcgatcgt
     3061 tgcgatcgtg ttaccaccaa atgcaggacg tgtcataaga agctgattgt gctgctgctc
     3121 ctgtcccggt gctgcgttca gcgggaaatc gccgatctca agcatcgtac agtcagcagt
     3181 aagacctgtc ttcacacgag cggaaacagt aggtccgagg tcacggccga ttgcagttgc
     3241 gccaaccagc atgatctccg gcttgtactc attgatcaca gatgccagtg catgtgcgta
     3301 cggctctgtt ctgtagtctt ttaactgcgg atcgtctacc acgatgactc tgtcagcgcc
     3361 gtactcagcg agctgatctg ccagctcctt aacgccggag ccaatcaata ctgcagttac
     3421 ttctgtgttt aaatcctttg ccagctcttt tccttttcca agtaactcga aagcaacgcc
     3481 gtctaatacg ttgtcaacct gctgtgcaaa gacaaatact cctttatatt cttctaaacc
     3541 cattttattc accacttttc cttatatttg ttagataatg tgcttctctt tgaacttgcc
     3601 gatcaggtat gctacggact catccggatc aaggacaacc ttctcgcctg cgcccttacg
     3661 taccttgtca gatgcctttg cgatctttgt cggtgatccc tttaatccaa gatcagaatc
     3721 atctacatcc ttaagatctg ctcttcccca tacggtaact tccttatcgt atgcgtcgaa
     3781 gattccgccc ggagtcatgt aacgcggctg attcagttcg gaaagtgctg tgatcaggca
     3841 cggcatcttt gcctttaact catggtatct gtcctcgtac tgacgctgaa caacgacata
     3901 ttctccatcg atcttgatgt cctgtgcgta ggaaataacc ggaagtccca gatgctctgc
     3961 gatctgcggt cctacctgag cggtatcacc atcgatcgcc tgacgtccgg tgatgatcag
     4021 atcgtaatcc agattgcgga gtgcgcctgc gattgtggtg gaggtagccc atgtatcagc
     4081 tccgcctaac acacgatctg ttacaaggat tcctttgtct gcgcccattg ccattgcctc
     4141 acgaagcacc tcgtctgcct tcggaagacc catggtaaga acggttactt ctgcgccgta
     4201 ctgctctttt aatctaagtg ctgcctcaag acctgctttg tcatccgggt tcatgatggt
     4261 aagcattgca gctctgtcta atgtaccgtc cgggttgaac ttaacgccgc ccttggtatc
     4321 tggtacctgt ttaatacata ctacgatatt catgtatttt tcactcctta tatttttata
     4381 ttatgccacg gattacgact atttcagtaa tgcaccagag ataaccattc tctgaacctc
     4441 actggttccc tcgtagatct ctgtgatctt tgcgtcacgc atcatacgct ctacatcgta
     4501 ctctctgatg taaccgtatc caccaaacag ctggacaacc tctgtggtaa cagccatagc
     4561 agtctctgct gcgaacagtt ttgcctttgc ggcctctacg gaatatacct tctgtgttgc
     4621 ctttgccata gcagctttgt atacaagaag ctgtgcagcc tcaattcttg cagccatgtc
     4681 agccagcttg aactgtgtat tctgctgctg ggcaatcgta cggccgaact gctttctctc
     4741 cttggtgtat gcgattgcgc ggtctaatgc gccctctgcg ataccaagtg cctgagcagc
     4801 aataccgata cgtccgccat ccagtgtgtg catagcgatc gggaatccct tgccctctac
     4861 accaagcagg ttctccttcg ggattctgca atcctcgaag atcagctcgt atgtagatga
     4921 tccgcggata cccatcttct tctccttggt tccgaaggag aagcccggag ctcccttatc
     4981 tacgataaat gcagagaagt tcttcttctt tctgcctctc ttatcctctg ttacgcttgt
     5041 gattgcgatt acgatataaa catctgcgac cttaccattt gtgatgaagc acttagagcc
     5101 gtttaatacc cactcgtctc cgtctaatac agccttggtc tgtgcgccct gcgcatcggt
     5161 acctgcaccc ggctcagtca gtgcgaatgc accgagcttc tcgcctgttg caagtggctt
     5221 aacgtatttc tgcttctgat cctctgtacc gtaggtcata atcggatcga tgcagagaga
     5281 agtatgtgca gaaacaacaa cacctgttgt agcgcatacc ttggacagct cctctacgca
     5341 cattacatag gtgagcggat cgcagccctg tccgccgtac tccttcggta ccgggatgcc
     5401 catgaagccg agcttctgca tcttcttcac attctcaacc gggaattcct ctgtctcatc
     5461 tacttcctga gcgagaggct ttacctcgtt ctcagcgaac tctctgaaca gggagcgcgc
     5521 catttcatgt ttcttgtcta aagtgaaatc catgatatca tttcctccat tattacctta
     5581 tattttactg agcatcaacc ggggtctttg tacggtcagc attgtataca tagaatccct
     5641 tgccgctctt tgcgccaaga ttgccgccgc gaaccatctt gcggattaac gggcatgcgc
     5701 ggtacttgct gtcgcctgtc tctttgtaga gaacatccat gattgcaagg cagatatcca
     5761 gaccaataaa atcacctaac tcaagcggtc ccatcggatg atttgcgccg agtttcattg
     5821 ctgcatcgat acctgcgata tcagatacac cttccatctt aatgaaagct gcctcattga
     5881 tcatcgggat taagatacgg tttacaacga agcctgctgc ctcatttacc tgtaccggag
     5941 tcttgccgat ctctacagag atcttcttga tcgcctcaac ggtctcttcc ggtgtattca
     6001 cacctgcgat aacctcgatt aacttcatac ggtctgccgg gttgaagaaa tgcataccta
     6061 ccattggacg ggtcagtccg ttgccgatct ctgtgatgga aaggctggat gtgttggatg
     6121 caaaaatgca ctctggcttt gcaatcttat ccagctcctg gaatgtagtc ttcttaacgc
     6181 ccatatcctc gaaagccgcc tctacgatga ggtcacaatc cttgcaaagg tcttccttta
     6241 agcctggggt aatctttgcg agaataccgt ctactgcttc ctgtgtcatt tttcctttct
     6301 cgacaagtct tgcatagcct ttcttgatct tctcttttcc gccgtcagcc cactcctgct
     6361 tgatgtcgca gagtgctact tcatatccgt ctacctgggc aaatgctttt gcaataccct
     6421 gtcccattgt tcctgcacca ataactccaa ctttcatgtc agtacctcct gaaatatcat
     6481 atatatattc taataactga ttctatacct tttaataaaa taggaacaaa gattcctatt
     6541 acgcaaagca agaacttctc cggtgccgcc cacaggctgg cgccggagaa gaagttctca
     6601 taactgcatt agtctctctc aacgatggta gagcatccca taccaccacc gatgcacaga
     6661 gtagcaagac ctctctttgc gtctctcttc tgcatctcat gtaataaggt aacaaggata
     6721 cggcatccgg aagctcctac cgggtgacca agtgcgattg caccgccgtt tacgtttacc
     6781 ttggacatat caaacttcag atctcttgca actgcaacag actgtgctgc gaatgcctcg
     6841 tttgcctcga tcagatccat atcatcgatg gtaagtcctg ttctctcaag tacctttctg
     6901 gtagatgcaa caggtccgac acccatgatc tcaggctcta ctccgccgag tgctccggct
     6961 acccatgttg ccatcggctt aacgccaagc tcttttgcct tctcctcgct cataacaacg
     7021 attgcagctg caccatcgtt aataccggaa gcgttacctg cggttaccag tccgccctct
     7081 ttgccggagc aacattttaa cttggacagt gactcagctg ttgtgccagg acgcggtccc
     7141 tcatcttttg cgaacataac ggtctctttc ttaaccttaa ccggaaccgg aacgatctcg
     7201 tcatcgaact tgccctcagc gattgccttc tcgcacttct gctggctgtt tgcggagaac
     7261 tcatcgagtt cttctcttgt aagaccatac ttctcacata cgttctcagc tgtgatcatc
     7321 atgtgatagt ggttgaatgc atcggtgagt gcatcgttta ccatggtatc aatgatggtc
     7381 gcattgttca tacgatatcc aaaacgagcc ttcgtcatgg cataaggagc catggacatg
     7441 ttctccatac cacctgcaac aacgatatct gcctgaccag ccagaatcat agtagctgct
     7501 tcattgacac atttcagtcc ggaaccacat acaacgttca gagtaactgc cggtacttcg
     7561 atcggaagtc ctgccttgat ggaagcctga cgtgcaacgt tctgtccctg tgctgcctgg
     7621 ataacacatc ccatcaatac ttcatctacc tgctccggct ttacgccagc tctgttcaat
     7681 gcctctttga ttacgattga tcccagctct gctgccggag tattgctcag tgctccaccc
     7741 atcttgccga tagcggtacg gcatgcgcct gctaaaacta ctttctttgc cattttgaat
     7801 tctcctttca gttttacaca caaaaccccg tatgtacggg gaatatgttc ctctttaaaa
     7861 taattttgcc aaaaaacgct gttaattttt taacaatctt tttgctaaaa aaaataaatt
     7921 caactttgca gttaaaattt atgtttctcc ctcttttttt cacaaggtgc attttaaata
     7981 atcggcgttt ttacaagctt tttaatactt tttcatgcta ccatatttca ctcttaaatg
     8041 caataacttt cttctttttt catctttcta atgttttctt tacgctcctt tttccccctc
     8101 tatacgtctg ttttacagtc tttttttgtt aaaaatttat catgcaaatt ttattttcca
     8161 aacaaaaaca aagcgattct tgtgtacttt tcacaaaaat cgccctgctg ccattctgcg
     8221 gttttccgca cttttttcac ttctaataga atacatggtt tccaattacg gttccctgta
     8281 tgatgccgtt attctgtctg aaatacaggc agcccaccgt aatattgccg tttagcacat
     8341 cctgcgccgc ctgaaggcag cttccgtcca cacccgcttc cagacgatac gccagtctgc
     8401 cgctcaccac cggcgagaac tgaccgctct ggtaaatcac acccgagaca gagttcggaa
     8461 aatacgaact cttcacacgg tttatcacaa cgcttccgac cgcaagcttc ccgtcgtagg
     8521 attctccgcc cgcctcgcac tggatgattg ctccaagcag gtactggtca ctgtccgtcg
     8581 gcacatagac cacggtggat gtatcctcct tctcctgctc cttaatcgcc gccagacgcg
     8641 cagcgtcctc cttcgccttc tggatctcca gctgcttctc gtactcgacc atctggttga
     8701 tcttatcctc caggtccgcg acgttggact gcgcatccgc cagatcttcc tgtgtctgcg
     8761 ccagattcgc cttggtggtg ttgatgagac tgctgacgtt cgcctgcttt ttcttcatgt
     8821 catcctgcat cgccaccagc tcggtcatat cactctccag atcttccttc tgggcggcta
     8881 tctgctcctg cagatcctgg tattccacaa gcttttttct gtcgtaggcg ttgatgtcgg
     8941 taatatattc cgtgcggttc aggaagtcgg aaaaagattc cgcctccgca agcatctgcc
     9001 ataccggcgt gcttccgttc tcatacatga actgaatccg cagcttcata tcctcatact
     9061 gtttcgcaga ctgtgcctcc gccgcagcca gatcctcctt cgcctggtca atctccccct
     9121 gtttgtccga aatctgcccc tccaggtcat tgatctgtgc gacaatatcg gaaagctgac
     9181 cgtttaaccc gctaagatcc gactccagtg cgtccttttt gccggagatg tcattgacgg
     9241 tatcctcggc atcctttttc tgatctttca gatcctcaat ctgattcttc gcatcattta
     9301 tgttgtcctg tgtcgtctcg gcataagatg tatttgccag aagcaggcac atcaccagcg
     9361 ccgctcccgc cacgcgtctc cacggaatct gtatcataag tacctctttc tccggaaaag
     9421 taggattttc tttcaaaaac cccggttcta agagtatcat atcagattgt atttcagctt
     9481 tcaatatgct atcatagagg gaagataaag aggattttgg tatgacaata ccggaagagg
     9541 gggagataat catgcaattt gtcaaaactg ctgatctaaa gcccggtatg cgccttgcaa
     9601 agccaatcta caacaggatg ggggttctgt tatacgaacg ggatacaagg ctcacgatcc
     9661 agggtattaa cagtattgag aattttggtc tgatcggcat ttttattctg gagccggctg
     9721 aaccgctgcc gccgctttcg cgggaagatc tggagtttga acagttccag accatctaca
     9781 tgttcaagtt aaaggacaac atggacaagc ttgtcgacaa tcttgtcccg tccacactgc
     9841 tctcgctggt cgatgatatc cagcggcatt acggcagtct tgaccacaag ctgaatttta
     9901 cgcagacact ccgcagttcc gcggactttg tatacaaaca ctcgatcagt gtcggtatcc
     9961 tatccgcaat gatctccaat gagatgcagc tcccggcaga agatatccgg gcgctgatca
    10021 cggcttccct gctgtatgat ttcggttatc tgtatgttcc acaggccatc ctcgacaagg
    10081 gcgacgacct ctcggacagc gaccggaatt ttatccagat gaatctggaa cgcggttatg
    10141 aatcaatccg cccgcgctat gaggagtgca atcttccgaa gatttcctta gagattatcc
    10201 agcagttcat cttccagaag agtcagacct taaagatcaa ggatccttcc ccggagacac
    10261 gtctgctctg tgatatttta aaggtggcag atcagtttga ccggcttacc gccatgaata
    10321 ttaacaatcc gccggtctcg gaggttgccg cgatgtcttt tttgcgcaga cacagccgga
    10381 cctacaatcc gcgcgtcgtt gccgcactgg cggaatgcat ccacattctc ccgaccggcg
    10441 cgtgcgttga tctctccgac ggtgagaagg cgctcgtcct cgtggaaaat gccgcggatt
    10501 ttacccgccc gatgatctta aagttctcca acaatatgat ctacgatctg agtgatccgg
    10561 tcatcggaga ttccctgcgt gtgacggaca tcatgaaaac catggacaac cggattgcga
    10621 tcgacgagga ggcgctcgag cattttgtcg cagaccagta catccgtgag acggctgacc
    10681 gtttccggca gaaaaagctt gccatcgcac agcgcaagca gaaagctgcc cagaagaaga
    10741 gcatggatga tcttttggac aatgccagag tgctcacacc tccgcccatt gcaccggtgc
    10801 cggaagagga cgcttccccg atcaggaaag ctccccgcaa gcgcatgaaa ctggtttaat
    10861 atttttcgca gccgaccgcc ggaacctgca tcgatttgca ggttccggcg tttttatgcg
    10921 cagttatttt gcttccacat aaggattgtt ttccgccatc cggcgcgcct ggcgcggagt
    10981 acagtggtaa cgctccttga acatccggta aaagagcttc tgattgaaaa agccatgccg
    11041 ctccatgatc tcctgtaccg gatcgtctgt gtgcagcaga tcctgataga tataattgag
    11101 ccgcacctga tttacatagc gcataaatga cgtgccagta ctctgcttaa agaaccggca
    11161 gaagtattcc cggttgagcc ccagttcatc cgccgcttcc tgcagcgtca tttcttcccg
    11221 gtagtgatga tccacataca tacagatctg ctccagccgc tccatcttcc ccgccctcgt
    11281 ctgcgttgcc accatggaga caggttccga aaaatgttcc accagacatg ccagcaattc
    11341 cagaatccgc gccgtgcttt ttaaccggta cgtctcattc tgattcacat aaagcaccgt
    11401 cagttctttt aaatacccgc agatttcatt gtaatattcc tgctgccctg gacggagacg
    11461 ctgtcccgcg cagcggatcg caaaaggttc cgcctccggc agatagcgcc gcagaagctg
    11521 ccttgacacg tggatacaga ttcccattgt ctgcggcagc gcatagatga cttcatgaat
    11581 tctggcatag tccatcacaa ccgcgtccaa cggattcagt tcgtattctt caccctccat
    11641 atgcacagta gcatgcccgt ttaatatgta gagaatctcc atctcccggt gccagtgaaa
    11701 cggagagtta tgatccatcg taacaaaccg gatatcaaag ccgacgtccg gttcgagcgt
    11761 aacattttca tatttatttt tctgttcttc cattttttct cctaaaagtc aatatcacct
    11821 aactttttgc taatatctta tctataatat taccatattt ccgtgtatta taatagctgt
    11881 caaagggaaa acctttgatg aacaagcaaa aatgtaccaa ttcaataaag gaggaaatta
    11941 ttatgttagc aaaaatcaaa gcattcttca tggagaatat cgacggagtc gcaatgggtg
    12001 ttgaagcaat gtacggagtt gacattcatc catattacaa ctaatcccgg agcaacgcca
    12061 tgacaacaga aaattttacc aaaaaagagc ctgtaacggt gcgatgagtt ctcatccatc
    12121 cgtatacagg ctctttctta tttcatagga aatacattgg cacattaatg tatggaagtg
    12181 ggtccttcct atgaaataaa aaccgctccg cgcggatgcg caactcgcgg tatggaaaat
    12241 atcgctttgc gaaccgctcg cgcgcggaga atctcgcaag cgagattctt tttttgttta
    12301 taattataaa ttcttcactt tcgcaatatc aaccggagtc agcgtatcca tcgctgtctc
    12361 aaggcttctt gcaagtgcgt ttgccgtatc catcgctgtg atacagtaca caccggtctc
    12421 gatcgcattt cggcggatca aaaagccgtc gcgcgtcttg tctccattgc cctgtgtcgg
    12481 ggtatcgatc acaagatcaa tcttatgacc aaggatcaga tccatgacgt tcggggattc
    12541 ctgtgtgatc ttattgacac gcagcgcatt caccccatgc tcctgcaaat atttcgcggt
    12601 gcttctggtc gcgtaaatct tgtagccgag cgcttcaaaa cgctttgcaa cgccaacggc
    12661 ctccggcttg tccgcatcct ttaccgtcat aatcatctgc ttatattttg gcagtgtcac
    12721 accggcacca aggaaagcct tatataatgc ctcgttgaat gtctttgcaa taccaaggca
    12781 ctcacctgtg gacttcatct ccggtccaag ggaaatctcc gctccgcgca gcttctcaaa
    12841 cgagaatacc ggcatcttga tggcaatgta atcagccgtc ggtgcaagtc ccggctcata
    12901 gccaagtccg cggattgtgt ttccgataat gaccttcgtt gcgagatcga caatcggaat
    12961 accggtcacc ttgctgatgt acggcacggt tcttgaagat ctcgggttta cctcgataac
    13021 atagacctct tcattcatcg cgataaactg gatgttgatc agtccgatga catgcagtgc
    13081 ctgtgccagg cgcttcgtat attccacgat cgtctctttt acatgatcgc tgatcgtcgg
    13141 tgccggatag acggaaatac tgtctcccga atggacaccg gttctctcga tatgctccat
    13201 gatacccgga atcaggatgt ccgttccatc acacacagcg tcgacctcga tctccttgcc
    13261 ctgcagatat ttatcaacaa ggatcgggtg atcctgtgca atccggttga tgatgccgat
    13321 gaattcctcg atctcgtcat cgttaaatgc aatcttcatg ccctgtccgc cgagtacata
    13381 ggacgggcgc acaagcaccg gatagcccag acggttcgcc acttccttcg cttcctccgc
    13441 ggtaaatacc gttccgcctg ctgctctcgg aattttggtc ttctcgagaa tctcatcgaa
    13501 aagctcacga tcctccgcag cgtcgacgtc ctccgccttg gttccgagga tcttcacacc
    13561 catcttcatc aggctctccg tcagcttgat cgcagtctgt ccaccaaact gcaccaccgc
    13621 accgtccggc ttctcaagtt ttacgatggc ttccacatcc tccggcgtca atggctcaaa
    13681 gtacagctta tccgcaatat caaagtctgt tgatacggtc tccgggttgt tgttgacgat
    13741 gacggtctcc cagccttctt ttgcgaatgc ccaggtacaa tgtacagagc agtaatcaaa
    13801 ctcaattccc tgtccgatac ggatcggtcc ggaaccaagt accagcacct tcttgttcgg
    13861 gtgcgtctct tccgcctcat tctcgctgcc gaatacggaa tagtagtacg gtgtggtcgc
    13921 ctcgaactcc gccgcacagg tatctaccat cttgtatgct gccacaatac cgtttgcgta
    13981 gcgcatatca tggatctctg tctcggtctt tccggtcagt tctgcgatca ccttatccgg
    14041 gaactcgatt cgttttgcct cttttaacag ttctaccgta agcggctcgc tctttaactt
    14101 ctgctccatc tcaaccagga ttgccagctt atcgatgaac cacttatcaa tcttggtgat
    14161 gtcgtgaatc acatcgtaat ccataccgcg gcgcagtgcc tctgcgatca cccagattct
    14221 ccggtcatcc acaacgtgaa gctgttttac cagttcctct ctggaaagtc cggtaaaatc
    14281 ataggacatc aggctgtcca catgctgctc taaggaacgg atcgccttca tcaaggctcc
    14341 ctcgaagtta ttgcagatac tcataacctc tccggttgcc ttcatctgtg tggtcagtgt
    14401 acgttttgcg gtaatgaatt tatcgaacgg cagtctcgga atcttgacaa cgcagtagtc
    14461 aagcatcggc tcaaagcttg cgtaggtttt tccggtgatg gcgttcttga tctcgtcaag
    14521 cgtatagcca agcgcgatct ttgcagcaac ttttgcaatc ggataaccgg tcgccttgga
    14581 tgcaagcgcg gaggaacggg acacacgcgg gtttacctcg atgacgcaat actcaaagct
    14641 ctccggattg agtgcatact gcacgttaca tccgcccgtg atatttaatt cagatataat
    14701 atttaaagca gaggtacgga gcatctgata ttccttgtcg cccagcgtct gtgacggtgc
    14761 gactacgatg gaatcgccgg tatgcacgcc gaccggatca atgttctcca tgttacatac
    14821 cgtgatgcag ttgccattcg catcacgcat tacctcatac tcgatctctt tccagcctgc
    14881 gatgcagcgc tccacgagca cctctccgac acggcttaag cggagtccgt ttgtcagaat
    14941 ctcgatcagc tcggtctcgt cgtgtgcaat accgccgccg cttccgccaa gcgtatacgc
    15001 cggacgaagc acaaccggat aaccgatggt attcgtaaac ttaataccat cctgcacatt
    15061 gtgcacaacc tcggatgccg cacaaggctc tccgatcttc tccatcgtgt ctttgaatgc
    15121 ctgacggtct tccgccttga aaatggtctc tgcagtcgta ccgatcagct tcacaccgta
    15181 cttatccaga attcctttct cggaaagctc catgccgagg tttaatccgg cctgtccgcc
    15241 aagggtcggg aggatagaat ccggtttttc ttttgcaatg atctgctcta acaccggcac
    15301 ggtgagcggc tcgatgtaaa cctggtctgc gatgtcttta tccgtcatga tggtcgccgg
    15361 gttgga
//
