LOCUS       c00178_gnlPro..        16165 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|HODHBIKM_178.
ACCESSION   c00178_gnlPro..
VERSION     c00178_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 20:25:22
            Original ID  :: gnl|Prokka|HODHBIKM_178
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 889
            Orig. end    :: 17054
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16165
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[10889:15132]"
                     /cutoff="10000"
                     /detection_rule="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /neighbourhood="10000"
                     /product="Putrescine2spermidine"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..14243
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /neighbourhood="10000"
                     /product="Putrescine2spermidine"
                     /protocluster_number="1"
     cand_cluster    1..16165
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /kind="single"
                     /product="Putrescine2spermidine"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16165
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Putrescine2spermidine"
                     /region_number="1"
                     /rules="(minimum(2, [AdoMet_dc, Spermine_synt_N,
                     Spermine_synth]) or (Orn_DAP_Arg_deC and Sacchrp_dh_C))"
                     /tool="gutsmash"
     CDS             663..1514
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) BPD_transp_1"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg178_2"
                     /sec_met_domain="BPD_transp_1 (E-value: 4.8e-14, bitscore:
                     42.8, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLLIDLLRGSNCTLMNKMKKNLQSNILLLPALIAGFFCYLFPIL
                     IAFGKSFFLGTGTDFVGIQNYVDLFENEAFSLAVRNLFHLWAIIVPVNLVIGIFIAEVY
                     IKLRKEKLCLFFLVPSILPAACVVTIASSILQKSPSQWGETPVAFYVFLIIVLWKTLGF
                     SILIFIVAIKSIESEIIDAAMLDGVNPLQCFWYIKLPIIKSSLLICGILTIYNSFRCFR
                     EAYLIGGSHPNEQLYSIQHFLQNNFMNMNYARLEAASVLVVLFVGAVVLIGMYLARKKR
                     NN"
     CDS             1514..2254
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) BPD_transp_1"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg178_3"
                     /sec_met_domain="BPD_transp_1 (E-value: 1.4e-11, bitscore:
                     34.7, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNPRKEATYRMLSLIAAVIFVLPCVFLVFPIFDINPDDLWQMDSL
                     MEFICAYKNTAILAIVGVLIQIVIALPAGYAIARIPSPKAQTFFLLTCVFFLLLPQQAL
                     MLPQYLVLMNIGWLDSLKGLLIMTAFQPWMILLFWFAAKRIDSSLFDSAICDGASNWGL
                     FRKIYAPIVRPYVMIAAFLSIAESWNLLEQPMTFLQSKEKYPLSMILMQLSTDNAELKN
                     VLCLLFAIPLMILFGTMVKKIIDT"
     CDS             2423..2728
                     /locus_tag="ctg178_4"
                     /transl_table=11
                     /translation="MEKTMTLNLRVNPTVKQQAEDVLKLLGIPMATAIDMYLRQITLTG
                     GIPFSLSLPKAPAALNADTMTDDQLHAALQVGIKEIQNGDTVDAASAFAQFREQHR"
     CDS             2725..3045
                     /locus_tag="ctg178_5"
                     /transl_table=11
                     /translation="MKQYDVKISHAALSDMEQIYSYIADRLLEPDTAMGQYNRIAEAIQ
                     SLNILPERCALVESEPERTQGLRQMLVDNYSVFYIVGEDAVSVARVLYSASDLVRRLRR
                     MK"
     CDS             3059..4804
                     /locus_tag="ctg178_6"
                     /transl_table=11
                     /translation="MTAVIYARYSSDNQREESIEGQIRECTAYAEKNGITVVKHYIDRA
                     LSAKTDNRPDFQQMIKDSEKRLFDIVLVWKLDRFARNRYDSAHYEYQLERNHVKLVSAT
                     EPISDSPAGIMVKSMLTGMAEYYSAELSEKVVRGMTENVLKGKYNGGTIPIGFKVDEEK
                     FFQIDPLKAPFVVEAFQRYNDGATMKELMNWLNDSGVTTNRNQKFTYNSVQTLLTNKRY
                     IGENHFKDIVMPDSIPAIVDKDLFEEVQQKIKKNSRAPARHKAEDDYLLTTKLFCGMCG
                     AMMFGECGTGRNKVVHHYYKCATAKRFKTCKKKTVRKEWLEDLVIAETMKLIQDDAVID
                     AIVAEVMELQEQENTTLPLLEKQMREVENGIENMLNAIQAGVLTNSTKLRLEKLEAQQK
                     ELEVRIAEEKIARPRLSENQVRFWLTRFRKLDPNVKSHRETLINTFVNAVYLYDEKVLI
                     AFNYKDGTKTITFDEIAAKDAPEGNGSDLGCFAPPRTPVSNGYRSFCFTCLEKGAARVD
                     SNSCGAVAEDSAKTAQWAVFSSAARAIHTRPPRTPVSEPGTGVSVLSALKRGCKGGFEQ
                     HRPAE"
     CDS             5051..5527
                     /locus_tag="ctg178_7"
                     /transl_table=11
                     /translation="MIYDTLNNLPNYLGVSDNLDTVIEYIMARDITTLPAGRTRIDGDK
                     AVVTVSTVTPQTSDKALFQRHDNHITLETDLDGSELFEVSLAELTPTKPTDEAADTTVG
                     TAGTSIAGMLCEGRFALYLAGEPYKSGLKAQGCGKLKKAVFSIELDPDEEETEE"
     CDS             5547..5786
                     /locus_tag="ctg178_8"
                     /transl_table=11
                     /translation="MGFFAVLAASLFAVFIFTVFGGYSLLLWCQQSLWMVVPPALVLAV
                     LVWTFLKMDDKITALQKRVDELEAAQKSTEKLEK"
     CDS             complement(5873..7189)
                     /locus_tag="ctg178_9"
                     /transl_table=11
                     /translation="MDLALFGRYFLDFALLYPSAFLCLASLWEKLRTPRRTACIAAGCI
                     TLLCIGCAALCAVFGLNSNSLLPAIVLVSFWLLRWRVTPEVTVSQTAFLFSISAVMMAV
                     CSLLSTLLNAQTEISNPQTVCLAFTALLRLGLAAMLTVLFWFTAVQWSRWLLREYSGEA
                     FWQSAWPLPALYAVFLVYCMPLNPAVVLVGRLKIISVLAVSISLFGIFLLLYEMYRVAR
                     EFTRNARLDRENQLLAMESRRYMELQTYLDNTRRLRHDFRQHLHVIAGLTETGQLEELK
                     SYLHQYESELSEHRPSLCANAAVDALAGYYDHAAGQQSVPVEWKLALPRQLPMPEADLC
                     TILGNLLENALHASQKLPPEQRRVQVMAQMLSPAMLGLVVENRYDGMLKKQQGILRSTK
                     HEGTGIGLVSAETVVHKYNGNLHLETEEQIFRVNVLLNL"
     CDS             complement(7207..7950)
                     /locus_tag="ctg178_10"
                     /transl_table=11
                     /translation="MEKEGVWMALPIAIVEDQTPDAQRLEELLQQQLPEAECTWFACGD
                     DFLRAAAEPGLYAVVFLDICMAGTNGIETARRLRQADPEVLIVFVTSSPEYVWDAFPVH
                     PFDYLLKPYQEEKFVHLAAELRRALRCKEPELEIRIARQSIQLPLRKVLYAIARNHYVL
                     ITTEDGEYRAMCSFAQIEEKLTARENFMSCNRGVIINMDKVLRFGEDCIEILDGTRLPV
                     RQKDKCTLLAHFTQYQFRHMRQELH"
     CDS             8522..9988
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) OKR_DC_1_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) OKR_DC_1_7_arginine"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg178_11"
                     /sec_met_domain="OKR_DC_1_C (E-value: 6.3e-12, bitscore:
                     36.3, seeds: 113, tool: rule-based-clusters)"
                     /sec_met_domain="OKR_DC_1_7_arginine (E-value: 2.5e-123,
                     bitscore: 401.9, seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNENKARSRLDQRRAPIYEALERFRQMRVVPFDVPGHKRGRGNPE
                     LTAFLGQQCVGVDVNSMKPLDNLCHPVSVIREAEELAADAFGAAHAFLMVGGTTSSVQS
                     MVLTACKRGDEIILPRNVHRSVLNALVLCGAVPVYVNPEVDKRLGISLGMKREQVAKAI
                     KEHPNAVAVLVNNPTYYGICSDLRAIVKMAHDAGMLCLADEAHGTHFYFGGGLPVSAMA
                     AGADMASVSMHKSGGSLTQSSLLLIGPNVHQGYVRQIINLTQTTSGSYLLMSSLDISRR
                     NLALRGRQVFHQVADIAEYAREEINAVGGYYAFGKELCNGDSVFDFDTTKLSVHTLDIG
                     LAGIEVYDILRDEYDIQIEFGDIGNILAYLSIGDRPQEVERLVSALAEIKRRYRTDGSG
                     LLSQEYIDPVVAASPQEAFYAPKKSLPLRETEGMVCSEFVMCYPPGIPILAPGERITKE
                     ILNYIEYAKAKGCSMTGPEDPEILHLNVLA"
     CDS             10001..10858
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Spermine_synt_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Spermine_synth"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg178_12"
                     /sec_met_domain="Spermine_synth (E-value: 4.3e-54,
                     bitscore: 173.1, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="Spermine_synt_N (E-value: 4.5e-23,
                     bitscore: 71.4, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEFWFSEFHTPDVKHSIRVNKQLYSKQSDYQRIDIFETPEFGRVL
                     TLDGNVMLTERDEFIYDEMIVHVPMAVHKEAKDILVIGAGDGGVVRELTRYDRVERIDL
                     VEMDPQVVEACRAYLPGNACRMDDRRVHIYFENALKYIRRCEEEYDLIIVDSSDPFGPS
                     EGLFTREFYGSCFNALKEDGIMVNQQGSPFYAEDASAMQRSHKRIASTFPISRVYQAHI
                     PTFAAGYWLFGFASKKYHPIDDLDAEAWKALNMRTRYYTTKLHIGAFYLPAFLEEMLRE
                     VEEH"
     CDS             10858..11733
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Arginase"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg178_13"
                     /sec_met_domain="Arginase (E-value: 1.7e-77, bitscore:
                     250.9, seeds: 235, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHPNVETFIGCDSSYRAASIVLYGAPYDSTTSYRPGARFGPAAIR
                     HESYGLETYSPYQNADLTDFDVFDSGDLELCFGSSELALADIEARAEEILKDGKFPLLL
                     GGEHLVTLGAVRAAVKKYPDLHIVHFDAHADLRDDYLGAKLSHACVLRRCHELVGDGHI
                     HQFCIRSGDRAEFEFAAQHTEMHKFDFTGLAELTAQLCESKVPVYLTIDLDCLDPSCFP
                     GTGTPEAGGVSFLQLLDAIRTVTKANIIGADLNELAPTLDTTGVSTATACKVLRETLIA
                     LDKGWPGFQV"
     CDS             11773..13032
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Sacchrp_dh_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Sacchrp_dh_NADP"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg178_14"
                     /sec_met_domain="Sacchrp_dh_C (E-value: 5.2e-45, bitscore:
                     144.9, seeds: 375, tool: rule-based-clusters)"
                     /sec_met_domain="Sacchrp_dh_NADP (E-value: 1.9e-33,
                     bitscore: 105.9, seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKVLIIGCGGVASVAIHKCCQVPEVFTEICIASRTKAKCDKLAA
                     ELAPTTTTKITTAQVDADKVEEVIALIKAYQPDLVMNIALPYQDLTIMDACLACGVNYM
                     DTANYEPENTDDPEWRAIYEKRCKEAGFSAYFDYSWQWAYAKKFEEAGLTALLGSGFDP
                     GVTQAYCAYAKKHEFDTIDTIDILDCNGGDHGYAFATNFNPEINLREVSAPGSYWENGH
                     WVEIPAMSIKREYNFDQVGDKDMYLLHHEEIESLAKNIPEAKRIRFFMTFGQSYLDHMR
                     CLEDVGMLSTTPVNFNGQEIVPIQFLKALLPDPASLGPRTKGKTNIGCIFTGKKDGKDK
                     TYYIYNVCDHQECYKEVGSQAISYTTGVPAMCGALMLLTGKWTTKGVHTVEEFDPDPYL
                     DALDKYGLPRSESHNPALVD"
     CDS             13032..14243
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Putrescine2spermidine: Orn_DAP_Arg_deC"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg178_15"
                     /sec_met_domain="Orn_DAP_Arg_deC (E-value: 1.2e-14,
                     bitscore: 44.8, seeds: 500, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVRDSRPPFAGLANLSEAQLHRLPTPCYLLDEAQLRRNGEILLG
                     VQQRTGCRILLAQKAFSNFNVYPVLAPYLAGTEASGLYESRLGREELPEKENHVFCAAY
                     RADEFEELLQYADHIVFNSPSQLAKFGPAAKAAGKSIGLRINPECSTQEGHEIYDPCAP
                     GSRLGTTRAQWDAAVAAHPELPALLDGLHFHTLCEQDADALAVTLAAVEKKFADLLPRM
                     KWLNFGGGHHITRPGYALATLESCILSVRQKYGVQVYLEPGEAWALNAGYLVTTVLDTL
                     RNGDTSLAILDMSAACHTPDVIEMPYRPPLLDAGEAGEKAHTVRLGGPTCLAGDIIGDY
                     SFDAPLAEGDKLIFGDMAIYTTCKNNTFNGMPLPPIWLLGADGNCRELVHFGYQDFKMR
                     LGAQ"
     CDS             14314..14577
                     /locus_tag="ctg178_16"
                     /transl_table=11
                     /translation="MADKTKKHHTFPCSAFILVEITGPILITVTLLQSMHGALPAERNP
                     HSFGVNKKSTTHFCAVLFVSGGDYRDRTGDLLHAMQALSQLS"
     CDS             complement(14744..15310)
                     /locus_tag="ctg178_17"
                     /transl_table=11
                     /translation="MSKTYSKTRILVECALMIAIGTVLSNIKFFTMPNGGSITLLSMLP
                     FVLVSFRHGAKWGLFTGFVNACLQMIMGFYPPPASTFLYFLGEVLLDYVLAFMALGLAE
                     LFARPFKNRTVGVAVGTFAAGFLRFMCSFLSGVLVWGNLNDGLAAWTYSLTYNGSYMLP
                     ETLLTMVAAVLLCRVAPQIFDRQAR"
     CDS             15607..15855
                     /locus_tag="ctg178_18"
                     /transl_table=11
                     /translation="MKADPEQRAVQLGEYIAAHNATVRAAAAAFGCSKSTVHKDVAVRL
                     RSISPALYGQVRAVLARNKAERHLRGGAATRRRYSRR"
     CDS             complement(15937..16164)
                     /locus_tag="ctg178_19"
                     /transl_table=11
                     /translation="YVIDQVRDPDSEESWISGLQFRDTVAALTPREKRIMELRYLRGKT
                     QMEVAQEIGISQAQVSRLEKGALQQFHTGG"
ORIGIN
        1 tagttgtcgg caaacattag catacgagaa agaattccgt acgggtgaaa tttcttatga
       61 gatgcaaaat ggtttgtttg acagtttcaa tccagaagta gtccaagatt attttgcaaa
      121 cggtgaacct tttgctagtc ttgacccaag ctatatgacg gtgggacttc ttcggcagtg
      181 tgcagctctt ggaatcaaaa ccgtaacact tcccattccc aatgagctag gcggtgttac
      241 tgctgaaatc ggttcttacg caatgggaaa tcgaaacaca aagcatccaa cagaggtaaa
      301 agcactttta gcttatcttc ttagtgaaga atgccagtcg agttcggcgt ttgcagataa
      361 agatatgttt cctgtccgac gtggatgtct taaaaaatgt atggaagcac aatatcaatt
      421 cagtgtctat gatgcatccc atgaaaaaat agggcaagaa gatattgaaa accgaaaaga
      481 gatgtatggt gacaatttga ctgatgcaca gctagatcaa cttgaaacaa tatgtgacaa
      541 gatcaatgca gcgcaatatc acacaatttg gtaccgtgcc ttgcagcttg atcaaagtga
      601 ggatggcgga aatcttctaa gcgaaacgat ggttcagtat tggaatgatg aaattaccct
      661 tgatgagctt gttgatcgac ttactccgcg gctcaaattg taccttgatg aataaaatga
      721 aaaagaatct tcagagcaat atccttcttc tgccggcact tattgccgga tttttttgct
      781 atctgtttcc aatcttgatt gcttttggga aaagtttctt tcttggaaca ggaactgatt
      841 ttgtcggcat acaaaattat gtggatcttt ttgaaaatga ggcattttca ctcgctgtta
      901 gaaatctgtt tcatttgtgg gccatcattg tacccgtcaa tttggttatt ggcattttca
      961 ttgcggaagt ttatataaag ctccgaaaag aaaaactttg tctgttcttc cttgttcctt
     1021 caatacttcc ggcagcttgt gttgtgacaa ttgcatcaag catcttacaa aagtctccta
     1081 gccagtgggg tgaaacacca gttgcatttt atgtgttcct tataattgtg ttatggaaaa
     1141 cgctgggatt ctcgattttg atttttatag ttgctataaa atccatagaa tccgagatca
     1201 tagatgccgc catgctagat ggagtcaacc ctctacaatg tttttggtat ataaagcttc
     1261 caatcataaa gagttcttta ttgatttgtg gaatcttgac gatttacaat agctttcgat
     1321 gtttccgtga agcctatttg attggtggaa gtcatccgaa tgagcaacta tatagtattc
     1381 aacacttttt gcaaaacaat tttatgaata tgaactatgc acgactggaa gcggcatctg
     1441 ttttggttgt gctttttgtc ggggccgttg tgctgatcgg aatgtacttg gcaagaaaaa
     1501 agaggaataa ctgatgaacc cacgaaaaga agctacatat aggatgttat ctttgatagc
     1561 tgctgtgatt tttgtgctgc catgcgtatt tcttgttttc ccgatatttg atataaaccc
     1621 agatgacttg tggcagatgg attctctgat ggaattcatt tgcgcctata aaaataccgc
     1681 gattcttgca attgtcggag tgcttattca aattgtgatt gcactgcctg caggttatgc
     1741 gattgccaga atcccatctc cgaaagcgca gacatttttt cttttgacct gtgttttctt
     1801 tttgcttttg ccacagcaag cacttatgct ccctcaatat ctggttctga tgaatattgg
     1861 atggttggat tctctgaaag ggctattgat aatgacggct ttccagcctt ggatgatttt
     1921 actcttttgg ttcgcagcaa aaagaattga cagtagcctg ttcgattcag caatttgtga
     1981 cggcgcaagc aactgggggc tttttaggaa aatttatgct ccaattgtac gaccgtatgt
     2041 tatgattgcg gcattccttt ctatcgctga gagctggaat cttttggaac aacccatgac
     2101 atttttgcag agcaaagaaa agtatccgct ctctatgatt ttgatgcagc tttcaacgga
     2161 taatgctgaa ttaaaaaatg tcctatgttt gctttttgcg attccgctga tgattttgtt
     2221 cggtacaatg gtaaaaaaga taatcgatac atgaaaaata agaatgacta gcttgatttc
     2281 atttcagcaa cagggtggat attttgatct ttgaacaatt ctgcaataaa tatgttgtgc
     2341 aatatggaga aatttaatta taagtttgga agttgttgat ttgcaacgca aaatacgtta
     2401 caataagctt gaggtgataa ccatggaaaa aacgatgaca ctcaatctcc gtgtcaaccc
     2461 tactgtcaag cagcaagccg aggatgtgct gaagctgctc ggcatcccga tggcaaccgc
     2521 cattgatatg tacctgcgcc agatcaccct gactggcggc attcccttct ctctgtccct
     2581 gccgaaggct cctgcggctc tgaacgctga caccatgacc gatgaccagc ttcatgcagc
     2641 cttgcaggtg ggcattaagg agattcagaa cggtgatacc gtggatgctg caagcgcatt
     2701 cgcacagttc agggaacagc acagatgaag cagtatgacg taaaaatttc ccatgcagcc
     2761 ctcagtgata tggagcagat ttacagctac attgccgacc gtctgctgga gcctgacacg
     2821 gctatggggc agtataaccg cattgcagaa gctatccaat cgctgaacat cctgccggaa
     2881 cgctgtgcgc tggtggaaag tgaaccggag cgcacccaag ggctgcggca gatgctggtg
     2941 gataactact cggtgttcta cattgtgggc gaggatgccg tgtcggtggc ccgtgtgctg
     3001 tacagtgcat ccgaccttgt gcgccgcctg cggagaatga agtgaaaggg gtgtttgcat
     3061 gaccgccgtg atttacgccc gctattccag cgataaccag cgcgaagaat ccatcgaagg
     3121 gcagatccgg gaatgtactg cctatgcgga aaagaacggc atcactgtgg tcaaacacta
     3181 cattgaccgt gccctttccg ccaaaaccga taaccgcccg gacttccagc agatgatcaa
     3241 ggacagcgag aaacggttgt ttgacattgt gctggtctgg aagcttgacc gttttgcccg
     3301 aaaccgctat gattcggccc actatgagta ccagttggag cggaatcatg tcaagctggt
     3361 gtctgccacg gagcccatct ctgacagccc agcgggtatc atggtcaaga gcatgctcac
     3421 cggcatggct gaatactatt ccgcagaact ttctgaaaag gtcgtgcgcg gcatgactga
     3481 gaatgttctg aagggcaagt acaacggtgg cacaattccc attggtttta aggtggacga
     3541 ggagaagttc tttcaaatcg acccgctgaa agctcccttt gtggtagaag cctttcagcg
     3601 gtacaacgat ggtgcaacta tgaaagaact gatgaactgg ctgaacgaca gtggtgtgac
     3661 taccaaccgc aaccagaagt tcacctacaa cagtgttcag acgctgctga cgaacaaacg
     3721 gtacattggt gaaaaccact tcaaggatat cgtaatgccg gacagcatcc cggccatcgt
     3781 ggacaaggac ttgtttgaag aagtgcagca aaaaatcaag aagaacagcc gcgctcctgc
     3841 ccgtcacaag gccgaggacg attacttgct caccaccaag ctgttctgcg gaatgtgcgg
     3901 cgcgatgatg ttcggcgagt gcggcacagg ccggaacaag gtcgttcatc attattataa
     3961 gtgtgccacc gcgaagcgtt tcaagacctg caagaaaaag accgtccgta aagagtggct
     4021 ggaagatttg gtcatagctg aaaccatgaa gctgattcag gacgatgccg tgattgatgc
     4081 catcgttgca gaagtgatgg agttgcagga acaggaaaac accacgcttc ctttgctgga
     4141 aaagcagatg cgcgaggtgg agaacggcat tgagaatatg ctgaacgcta ttcaggcggg
     4201 tgtgctgacc aactccacca aattacgttt ggaaaagctg gaagcccagc agaaagagct
     4261 tgaggttcgg attgccgaag aaaaaatcgc ccggcctcgg ttgagtgaaa atcaggttcg
     4321 gttctggctg actcggttcc gcaagctcga cccgaacgtg aaaagccacc gggaaacgct
     4381 catcaataca ttcgtgaacg ccgtttatct ctatgatgaa aaagttttga ttgcattcaa
     4441 ctacaaagac ggcacaaaaa ccatcacttt cgatgaaatc gccgccaaag atgccccaga
     4501 gggcaatggt tcggatttgg gttgcttcgc tccaccaaga actccggtat ccaatgggta
     4561 ccggagtttc tgttttacct gccttgaaaa aggggctgca agggtggatt cgaacagctg
     4621 cggcgctgtc gcagaagaca gcgcaaaaac agcccagtgg gctgttttta gcagcgcggc
     4681 tcgcgcaatc cacacgcgcc caccaaggac tccagtatcc gaaccgggta ctggagtttc
     4741 tgttttatct gccttgaaaa ggggctgcaa gggtggattc gaacagcatc gacccgccga
     4801 atagtccggc gggggaaagc ccctgtgcaa cagcgacgac cgctgccagc ggcagaaaca
     4861 gggaggagct gttggggctg cggccagcag gatgcgcgtg ccgcccaagg cacgatgcag
     4921 ccgctgggag ccgcgacccg ggttcctttt ctgcgcggct cgcgacatct gcccgcacac
     4981 atattgcatc tgtccctgac ctgtgatacc atacaggtaa ctgaaacaac acagacggag
     5041 gactttttct atgatctacg ataccctgaa caacctgccc aactatctgg gcgtaagcga
     5101 caatctggac accgtgatcg agtacatcat ggcgcgggat atcaccaccc tgcctgccgg
     5161 gcgcacccgc atcgatgggg acaaggcggt ggtcaccgtg agcaccgtca cgccccagac
     5221 ctccgacaag gcactgttcc agcggcacga caatcacatt acgctggaga ctgatttgga
     5281 cggcagtgag ctgtttgagg taagccttgc ggagctgacg cccaccaagc caaccgatga
     5341 agccgccgac accaccgtag gcactgccgg taccagcatt gccggaatgc tgtgcgaggg
     5401 acgctttgcc ttgtatctgg cgggggaacc gtataaatct ggcttgaagg cgcagggttg
     5461 cggcaagctg aaaaaggccg tgttcagcat cgagctggac ccggatgagg aagaaacgga
     5521 agaataactg aaaggagact ttctgtatgg gattttttgc tgtactggct gcaagtctgt
     5581 ttgccgtatt tatttttact gtattcggcg gctattcgct gctgctctgg tgtcagcagt
     5641 ccctgtggat ggttgttcct cccgcgctgg tgctggctgt tctggtctgg acatttttga
     5701 aaatggacga taagatcacc gccctgcaaa agcgggtgga cgagctggaa gccgcacaaa
     5761 aaagcacgga gaagcttgaa aaataataca gcgccgccct tcgtagagaa acctctctgc
     5821 aaaggacggc gctgcttttt ttgtgaacgc tttcacgttg gcctgccggt ggttacagat
     5881 ttaacagaac attcacccgg aagatctgct cctcggtctc cagatgcaga ttgccgttat
     5941 atttgtgcac taccgtctcg gcagatacca gcccgatgcc ggtgccctcg tgcttggtgg
     6001 agcgcaagat accctgctgc tttttcagca tgccgtcgta acggttctcc accacaagcc
     6061 ccagcatggc gggactgagc atctgcgcca tcacctgcac ccggcgctgc tccggcggca
     6121 gcttctggct ggcgtgcagg gcgttttcca gcagattgcc cagaatggtg cacaggtcgg
     6181 cctccggcat gggaagctgc cgaggcagtg ccagcttcca ctccacagga acgctctgct
     6241 gcccggctgc atggtcgtaa tatccggcca gtgcatccac ggcggcattg gcgcacaggc
     6301 tgggacggtg ctcgctgagc tcgctttcat actggtgcag atagcttttc agctcctcca
     6361 gctgcccggt ctcggtcagt ccggcaatca catgcagatg ctgccggaag tcgtgccgca
     6421 gacggcgtgt gttgtccaga taggtctgta actccatgta ccggcgggat tccatggcca
     6481 gcagctggtt ttcccggtcc agccgggcat tgcgggtaaa ctcccgggca acgcggtaca
     6541 tctcgtacag cagcagaaag atgccgaaca gcgagatgga taccgccagc accgagatga
     6601 tcttcagccg cccgaccagc accacggcgg ggttcagcgg catacagtat accagaaaaa
     6661 cggcatagag ggcgggcagc ggccacgcag actgccagaa ggcttcaccg ctgtactccc
     6721 gcagcagcca ccggctccac tgcacggcgg tgaaccagaa cagcacggtg agcatcgcgg
     6781 caaggcccag ccgcagcagc gccgtgaagg caaggcagac ggtctgtggg ttggagatct
     6841 cggtctgggc gttgagcagc gtcgacagca gggaacacac cgccatcatc acggcagaga
     6901 tggaaaacag aaacgcggtc tggcttacgg tcacttccgg cgttacccgc cagcgcagca
     6961 gccagaagga gaccagcacg atggcgggca ggagagaatt gctgttcagc ccgaacacgg
     7021 cgcagagcgc ggcgcagccg atgcacagca gggtgatgca tccggcagcg atgcaggcgg
     7081 tgcgcctggg ggtgcgcagc ttttcccata gggatgccag acacagaaac gcgctggggt
     7141 acagcagtgc aaaatccaga aaataacggc cgaacagagc aagatccatg gcggctgctc
     7201 ctttcctcag tgcagctcct gccgcatgtg gcggaactgg tattgtgtaa agtgggcaag
     7261 cagagtgcat ttatcctttt gccgtaccgg caggcgggtg ccgtccagga tctcgatgca
     7321 gtcctccccg aaccgcagca ccttgtccat gttgatgata acgcctcggt tgcagctcat
     7381 aaagttttcc cgtgcggtaa gcttttcttc gatctgcgca aaactgcaca tggcgcggta
     7441 ctcgccatcc tcggtggtga taaggacgta gtggttccgg gcaatggcgt acagcacctt
     7501 gcgcagcggc agctgaatgc tttggcgggc aatgcggatc tccagttccg gctccttaca
     7561 acgcagcgcc cgccgcagct cggcggcaag gtgcacgaat ttttcctcct gatagggttt
     7621 gagcaggtaa tcgaaggggt gcaccggaaa ggcatcccat acatattccg gggaggaagt
     7681 tacgaatacg atcagcacct ccgggtcggc ctgccgcagt cggcgggcgg tctcgatgcc
     7741 gttggtgccc gccatgcaga tatccagaaa caccacggcg tataagccgg gctctgctgc
     7801 ggcacggaga aaatcatccc cgcaggcaaa ccatgtgcac tcggcttcgg gcagctgctg
     7861 ttgcagcaac tcctccagcc gctgggcgtc cggggtctga tcctctacga tggcgattgg
     7921 cagtgccatc catacaccct ctttctccat tcattgttcc tttattatag catactgcgg
     7981 cgggaagggc atctgctttt ttgcacaaaa cgctccattt tgcgcgccga gcgccgccct
     8041 gcacacccgc atcgggcgac tgccaaaaag ttttggttga cagacggggc gaatcatgtt
     8101 attcttttgt tgattttgag agacgccgcc ttgcagagtc ttttcaaagc aatttactcg
     8161 ggaccgccca aacggggcta aggccatacg gacagccggg tccactgccg accggcggcg
     8221 caagctgcca ttattgattg agtttgaagc tcaaatttta taagttggtt cctttacaac
     8281 catgaaattg cgcagcctat gcgcagactt gtgaaacggt caataagagt agtaaaagtg
     8341 tagttgctat atagactctc atcaccccgt ctttttggat cgcgaataac gcgcagcacc
     8401 ggcacttacg gctgggtgct ttatcagcgc ggaaaaagct gctccaagcg caggtctgca
     8461 tatttgtgca gtgtctgcgc ttttttgttg tgcaaaaaga agaacaggga cggaggaaat
     8521 gatgaacgag aacaaagcgc gttcccggct ggatcagcgc cgtgcgccca tttacgaggc
     8581 gctggagcgg ttccggcaga tgcgggtggt gccttttgac gtgcccggcc acaagcgggg
     8641 ccgcggcaac ccggagctga ccgcttttct gggtcagcag tgcgtgggcg tggacgtgaa
     8701 cagtatgaag ccgctggata acctttgcca cccggtgtcg gtcatccggg aagccgagga
     8761 gcttgccgcc gatgcctttg gcgcggcaca cgccttttta atggtgggcg gcaccaccag
     8821 cagcgtgcag agcatggtgc ttaccgcctg caagcggggc gatgagatca ttctgccccg
     8881 caatgtgcac cgcagcgtgc tgaacgcgct ggtgctgtgc ggcgcggtac cggtgtatgt
     8941 gaatccggag gtggataagc gcctgggcat ctcgctgggc atgaagcggg agcaggtggc
     9001 caaggccatc aaggagcacc ccaacgctgt ggctgtgctg gtgaacaacc ccacctacta
     9061 cggcatctgc tccgatctgc gtgccatcgt aaaaatggcg cacgatgccg gaatgctctg
     9121 ccttgcggac gaagcccacg gcacccactt ctactttggc ggcggtctgc cggtgtctgc
     9181 catggcggca ggcgcggata tggcctcggt gtctatgcac aagagcggcg gcagcctgac
     9241 ccagtccagc ctgctgctca tcggccccaa tgtgcatcag ggctatgtgc gccagatcat
     9301 caacttgacc cagactacct ccggcagcta cctgctgatg tccagtctgg atatctcccg
     9361 ccgcaatctg gcgctgcggg gacggcaggt gttccatcag gtggcggaca ttgccgagta
     9421 cgcccgcgag gagatcaatg ccgtgggcgg ctactacgcc tttggcaagg agctgtgcaa
     9481 cggcgattcc gtctttgatt tcgacaccac caagctcagc gtccatacgc tggatatcgg
     9541 tctggcgggc atcgaggtct atgatatcct gcgcgacgag tacgatattc agattgagtt
     9601 cggcgatatc ggcaacatcc ttgcctacct gtccatcggc gaccgtccgc aggaggtgga
     9661 gcgtctggtc agtgcactgg ccgagatcaa gcgccgctac cgcaccgacg gttctggtct
     9721 gctgagccag gaatacatcg accccgtggt ggcggccagc ccgcaggagg ctttctacgc
     9781 ccccaaaaag agcctgcccc tgcgggagac cgagggcatg gtgtgcagcg agttcgtcat
     9841 gtgctatccc ccgggcatcc ccatccttgc acccggcgag cgcatcacca aggagatctt
     9901 gaactacatc gagtacgcca aggccaaggg ctgcagcatg actggcccgg aggaccccga
     9961 aatcttgcac ctgaatgttc tggcataagg agggaaagag atggaatttt ggttttcaga
    10021 gtttcacacc ccggatgtga agcacagcat tcgtgtaaac aagcagctct actccaagca
    10081 gagcgattat cagcgcattg atatctttga gaccccggag ttcggccggg tgctcacgct
    10141 ggacggcaac gtgatgctga ccgagcgcga cgagttcatc tacgatgaaa tgatcgtcca
    10201 tgtgcccatg gcggtgcata aggaggccaa ggatattctg gtcatcggtg ccggagacgg
    10261 cggcgtggtg cgggagctga cccgctacga ccgtgtggag cgcatcgacc ttgtggagat
    10321 ggacccgcag gtggtggagg cctgccgcgc ttacctgccc ggcaatgcct gccgtatgga
    10381 tgaccgccgg gtgcatatct attttgagaa tgccctgaag tatatccgcc gctgcgagga
    10441 ggagtacgac ctcatcattg tggactcctc cgaccccttc ggcccctccg agggtctgtt
    10501 cacccgcgag ttctacggca gctgcttcaa cgccctgaaa gaggatggca tcatggtcaa
    10561 ccagcagggc agccccttct acgccgaaga tgccagtgcc atgcagcgca gccacaagcg
    10621 cattgcatcc accttcccca tcagccgtgt gtatcaggcg catatcccta cctttgcggc
    10681 agggtactgg ctgttcggct ttgcaagcaa aaaatatcat cccattgatg atctggacgc
    10741 agaagcgtgg aaggcactga atatgcgcac ccgctactat accaccaaac tgcatatcgg
    10801 agcattctac ctgccggctt ttctggagga gatgctgcgg gaagtggagg aacactgatg
    10861 caccccaacg ttgagacctt tatcggctgc gacagcagct accgcgccgc cagcatcgtg
    10921 ctgtacggtg cgccctacga ttccaccacc agctaccgcc ccggtgcacg gttcggcccg
    10981 gcggccatcc ggcacgagag ctatggtctg gagacttaca gcccctacca gaacgccgac
    11041 ctgaccgatt ttgacgtgtt cgacagcggc gatctggagc tgtgctttgg ctccagcgag
    11101 ttggcactgg ccgatatcga ggcccgggca gaggagatcc tgaaggacgg caagttcccg
    11161 ctgctgctgg gcggcgagca tctggtcacg ctgggcgccg tgcgggctgc ggtaaagaaa
    11221 taccccgacc tgcacatcgt ccacttcgac gcccacgccg acctgcggga cgactatctg
    11281 ggcgcgaagc tcagccacgc ttgtgtgctg cgccgctgcc acgagctggt aggggatggc
    11341 cacatccatc agttctgcat ccgcagcggc gaccgggcag aatttgagtt tgctgcccag
    11401 cacaccgaga tgcacaagtt cgattttacc ggtcttgccg agctgaccgc acagctgtgc
    11461 gagagcaagg tgccggtgta cctgaccatc gatctggact gccttgaccc ctcctgcttc
    11521 ccgggtaccg gtaccccgga agctggcggc gtaagctttt tgcagctgct ggatgccatc
    11581 cgcactgtga ccaaggccaa catcatcggt gcagacctga acgagcttgc ccccacgctg
    11641 gacaccaccg gcgtttccac cgccaccgcc tgcaaggtgc tgcgcgagac cctgatcgcg
    11701 ctggacaagg gctggccggg ctttcaggta taaatacgaa cctaccattt tacagataaa
    11761 ggagtaaccg acatgagcaa agttctgatc atcggctgcg gcggcgtggc ctccgttgcc
    11821 atccataagt gctgccaagt gcccgaggtg ttcaccgaga tctgcatcgc cagccgtacc
    11881 aaggcaaagt gcgataagct ggctgctgag ctggctccca ccactactac aaagatcacc
    11941 accgcacagg tggacgcaga caaggtggag gaggtcatcg ccctcatcaa ggcttaccag
    12001 cccgacctcg tgatgaacat cgccctgcct tatcaggatc tgaccatcat ggacgcctgc
    12061 cttgcctgcg gcgtcaacta catggacacc gccaactacg agcccgagaa caccgacgac
    12121 ccggagtggc gcgccatcta cgagaagcgc tgcaaggagg ccggcttctc tgcctacttc
    12181 gattacagct ggcagtgggc ctacgccaaa aagttcgagg aagccggcct gaccgccctg
    12241 ctgggcagcg gcttcgaccc gggtgtgacc caggcttact gtgcctacgc caaaaagcac
    12301 gagtttgata ccattgacac catcgatatt ctggactgca acggcggcga ccacggctat
    12361 gcctttgcca ccaactttaa cccggaaatc aacctgcgcg aggtgtccgc tcccggcagc
    12421 tactgggaga acggccactg ggtagagatc ccggctatga gcatcaagcg ggagtacaac
    12481 ttcgatcagg tgggcgacaa ggatatgtac ctgctgcacc acgaggagat cgagtctctg
    12541 gcaaagaaca tcccggaggc aaagcgcatc cgcttcttca tgacctttgg ccagagctat
    12601 ctggaccaca tgcgctgtct ggaggacgtg ggtatgctgt ccaccacccc cgtcaacttc
    12661 aacggacagg agatcgtgcc catccagttc ctcaaggcac tgctgccgga ccctgccagc
    12721 cttggccccc gcactaaggg caagaccaat atcggctgca tctttaccgg caaaaaggac
    12781 ggcaaggaca agacctacta catctataac gtctgcgacc atcaggagtg ctacaaggaa
    12841 gtgggcagtc aggccatcag ctacaccacc ggcgtgccgg ctatgtgcgg tgccctgatg
    12901 ctgctcaccg gcaagtggac caccaagggc gtgcacactg tcgaggagtt tgatcccgat
    12961 ccgtatctgg atgcactgga taagtacggc ctgccccgct ccgagagcca caacccggct
    13021 ctggtggact gatgcgggtg cgcgacagcc gcccgccctt tgcggggctg gcaaacctgt
    13081 ccgaggcgca gctgcaccgc ctgcccaccc cctgctatct gctggacgaa gcccagctgc
    13141 gccgcaacgg cgagatcctg ctgggggtgc agcagcgcac cggctgccgc attctgctgg
    13201 cgcagaaggc tttttccaac ttcaatgtct acccggtgct ggcaccctat ctggcaggta
    13261 ccgaggccag cggcctgtac gagagtcgct tgggcaggga agaactgccg gagaaggaga
    13321 accatgtgtt ctgcgccgcc taccgggcag atgagtttga ggaattgctg caatacgccg
    13381 accacatcgt gttcaactcg cccagccagc tggcaaagtt cggcccggcg gcaaaggcgg
    13441 cgggcaaaag catcggtctg cgcatcaacc cggagtgctc cacgcaggag gggcacgaaa
    13501 tttacgaccc ctgtgccccc ggcagccgtc tgggcaccac ccgtgctcag tgggacgccg
    13561 ccgtggcagc gcacccggag ctgcccgccc tgctggacgg tctgcacttc cataccctct
    13621 gcgagcagga cgccgatgcg ctggcggtaa cgctggccgc agtggagaaa aagtttgcag
    13681 acctgctgcc cagaatgaag tggctcaact tcggcggggg gcaccacatc acccgcccgg
    13741 gctatgccct tgctacgctg gaaagctgca ttctttcagt gcggcagaag tacggcgtac
    13801 aggtgtatct ggagcccggc gaggcttggg cgctgaacgc gggatatctc gtcaccaccg
    13861 tgctggacac cctgcgcaac ggggatacca gtcttgccat tctggatatg tccgcagcct
    13921 gccacacccc ggatgtcatc gagatgccct accgcccgcc gctgctggac gccggcgagg
    13981 caggagagaa ggcgcacacc gtccggctgg gcggccccac atgccttgcg ggggatatca
    14041 tcggggatta cagctttgac gcccctcttg ccgagggaga taagcttatc tttggcgata
    14101 tggccatcta caccacctgc aagaacaaca ccttcaacgg gatgcccctg ccgcccatct
    14161 ggctgctggg cgcagacggc aattgccggg agctggtgca ctttggctat caggacttca
    14221 aaatgcgctt gggcgcacag taaaataaaa agcgtttgtc acggcctgcg ggctgcgaca
    14281 aacgcttttt tcatgaaagg ggacgtaagg tgaatggcag ataaaacaaa aaagcaccac
    14341 acgtttccgt gtagtgcttt cattctggtg gagattaccg ggccgattct gatcacggtg
    14401 accctcttgc agtccatgca cggcgctctc ccggctgagc gaaaccctca ctcgtttggc
    14461 gtcaacaaaa aaagcaccac acatttctgt gcagtgcttt ttgtttctgg tggagattac
    14521 cgggatcgaa ccggtgacct cttgcatgcc atgcaagcgc tctcccagct gagctaaacc
    14581 cccagatgtc ttgccttgtg cctgacgacg tgtgttatta taccagccga ggatgcgctt
    14641 gtcaacagtt ttttgaaaaa attttgcagc aaaaatcccc gcagggcgtg tgcccggcgg
    14701 ggatcgggaa gcgggggagt gctctttttt gaaaaactac gccttagcgt gcctgacggt
    14761 caaagatctg cggagccacg cggcacagca gcacagcggc caccatggtg agcagggtct
    14821 cgggcagcat atagctgccg ttgtaggtca ggctgtaagt ccatgcggcc agaccatcgt
    14881 tcaggttgcc ccacaccagc acaccggaca aaaagctgca cataaagcgc aggaaaccgg
    14941 cagcaaaggt gcccacggct acgcccacgg tgcggttctt gaagggacgg gcaaacagct
    15001 cggccagacc cagtgccata aaggccagca catagtccag cagcacctca ccgaggaagt
    15061 agaggaaggt ggaagcggga ggagggtaga aacccatgat catttgcagg caggcgttga
    15121 caaagccggt gaacaggccc cactttgcgc cgtggcggaa ggacaccagc acaaagggca
    15181 gcatactcag cagggtaatg ctgccgccgt tgggcatggt gaagaacttg atgttggaaa
    15241 gcaccgtgcc aatagcgatc atcagggcgc attccaccag aatgcgggtc ttggaatagg
    15301 ttttagacat gatggaaaaa ttcctctctc atagtagtac acaaaaacaa aatgcgcctg
    15361 ctggcagcag acgcatgaag gtttgttgaa cgtaccggac ggttccgcaa actccctacg
    15421 ccggcattgc ccggatcagg taaagggtac tccgcgcgat gcggatctca gccttacggc
    15481 acccctgttt ttatgtccgc ccacagtata cgcgccgggg gacaaaatgt caagcccgca
    15541 gacatattcc gccccggcgg cgcgtatgtt ataccattgc aaagctggaa cgcagggagg
    15601 cgggatatga aagccgatcc ggaacagcgc gccgtgcagc tgggcgagta cattgccgcc
    15661 cacaacgcca cggtgcgggc agcggcggct gcgttcgggt gcagcaagtc caccgtgcac
    15721 aaggacgttg ccgtgcggct gcgcagcatc agccctgcgc tgtacgggca ggtgcgtgcc
    15781 gtgctggcgc gcaacaaggc cgagcgtcac ctgcggggcg gggctgccac ccggcgcaga
    15841 tacagccgcc gctaaacccc aaaaagaccg ctacattgtg cagcggtctt ttttgagcca
    15901 ctttttcatg gagggcgcag cgaaaagcgg ctgcttttat cccccggtgt ggaactgctg
    15961 caatgcgcct ttttccagcc ggcttacctg tgcctgactg atgccgatct cctgcgccac
    16021 ctccatctgg gtcttaccgc gcagataccg cagctccata atgcgctttt cccggggcgt
    16081 aagggcggct accgtgtccc ggaactgcaa cccgctgatc cagctttcct cgctgtccgg
    16141 gtcgcgcacc tgatcgatga catac
//
