LOCUS       c00249_gnlPro..        12806 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|HODHBIKM_249.
ACCESSION   c00249_gnlPro..
VERSION     c00249_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 20:25:22
            Original ID  :: gnl|Prokka|HODHBIKM_249
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12806
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12806
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[6290:12133]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      6291..12133
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..12806
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..12806
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             136..1023
                     /locus_tag="ctg249_1"
                     /transl_table=11
                     /translation="MELFLDVLGETLVDTAKMLPFLFLAYLLIEYIEHRHGERIEALLA
                     GGGRWGAVPGAVLGCVPQCGFSAIASNFYASRVITLGTLMAVYLATSDEAIPLLVSMPA
                     YWDKLAVLMVIKVVYAIVVGFVLDFVLRGVLPKGLRGGYTGHADEVDCHEEHSDAEGNE
                     KPIWQAALRHTLEIFVFIFAFSLVFGMIVEGVGEDVFAEMLGGMGFFQPVVAALVGLIP
                     NCAASVLLTQLYVEGALRFSSLVAGLCTGAGVGLAVLWRANPSWKQNLFITGLTWAAGA
                     FVGVAMQVVVAVFA"
     CDS             1162..2055
                     /locus_tag="ctg249_2"
                     /transl_table=11
                     /translation="MQYKILASDYDNTLMPFGEAKPRPAVVKAVKKLQAAGGKFVLSTG
                     RSYPGIRDKNQLGGIRYDYAITCNGACVVDRQGNVIAEHPLTSEEMYVLVDFCEDYNYP
                     LQFNFRDAYYAYCEYEYLHTGYQMMNSPGLDCVDGEDQDRHLVDMPHAAFAAMPPQEVE
                     RFHEKYGYLGLHWMQTGAQNADGYCYYDIVRGGMDKGVGLADLCAQMGLTLADAVAVGD
                     SANDVGMLKVAGLSACMANGTPDAKAAADRIIGDVREDGVAALIEELWFNGPRAEPSGK
                     DFGSAWGNIESAGGSL"
     CDS             2052..2540
                     /locus_tag="ctg249_3"
                     /transl_table=11
                     /translation="MSFAPVYDDRSRALILGTWPSPKSREMAFYYGHPQNRFWPLLAAL
                     TGEPLPVREDIAAKKQLLLRHGLALWDTLESCTITGASDASIRDVVPNDIAGLLRKAPI
                     RAVFCNGATAYRIYTKYQQPLTGIPAVRLPSTSPANAACSPARLEELWGAALADWIVK"
     CDS             2644..3273
                     /locus_tag="ctg249_4"
                     /transl_table=11
                     /translation="MSKIIRTQKPSVLPFYAMALVFVVLCAVLPVYKLWALLVALGGAA
                     VAFGVAKKNCPPRVVEHEVPFHTGVEDVDQMLTDIQQKLDTLHALNEALPDPQLSAAMT
                     RMEKAGRSIVEAVEANPAKAKQVRRFANYYLPDAVNVLQQYAKLAKQGVRGENAAAIRA
                     EVEHNAASIATAFENQLDALYAAESMDLSADLTVLQNMLKGQGLSK"
     CDS             3317..4468
                     /locus_tag="ctg249_5"
                     /transl_table=11
                     /translation="MADNTLNFDLDAPAVPTLTLDPTPAAVPQEEKPAAAPAPEAQVNL
                     TPEEQAMVDQFAQKIDITNSQQVLQYGSACQKKIGDFSEAALSKVSTKDLGEVGDMITD
                     LIGELKSFDANEEQQKGIMGFFKKKTSQLDALKTKYDKTETNVEKIQSMLEAHQVQLLK
                     DIAMLDKMYELNMAYFKELSMYILAGKKKLADVRANELQQAMDKAKVSGLPEDAQAARD
                     LADQCERFEKKLYDLELTRNISLQMGPQIRLLQNNNTMMAEKIQSTIVNTIPLWKNQMV
                     LALGLAHSQQAMQAERAVTNMTNDLLKKNAEALKLGTIETAKESQRGIVDIETLQQTNK
                     SLIETLDELNKIQSEGRAKRAAAEQELTRIEDELKTKMMEIRS"
     CDS             4470..5228
                     /locus_tag="ctg249_6"
                     /transl_table=11
                     /translation="MANADFSQNKQTVPGGFDAGSYREKAKPEQVVRLTPRQQKLAALE
                     AKLPAALSTRAAALALSVVVMLAAFFGFGSAKLRGKYNTARQWFTAGVAADNGYNLSEE
                     LTTRENTAANILTTASNTLGADSAEVLAAQTALNDFSACLQAVQNGGKSQSLTSLPYYQ
                     GSTMHALYQADQALGAAIDQLYAKLQEQAADPMKMDAVQGQYGQFNSAATIIGTLQYNT
                     AVYEYQKDVGGFPAGVLGALSGVKEVEPFA"
     CDS             5225..6148
                     /locus_tag="ctg249_7"
                     /transl_table=11
                     /translation="MKNFAKRISALVLAVVVSAAVLCPAAFAAQLPSLPKDQCVVDGAG
                     VLSSSTVQTITELNAQLESSCSGAQIGVLTVEYTGNDSTEDYATQAFNAWGIGSSSKNN
                     GVLILLVMESAQYADGDYYLTYGDGFRNTTLAKQSSAIAQTMEDQFAAKDYDGAVTTCA
                     RNVANTIADIYGVSLSGSAGNGSTVQPGYQGGQSSGGSALTDILTLVVSVVLLIVIIRS
                     MAYVFASPCGWLWCFGGPRPPRGRRRGPHNPPPPPGGFYGGFGGMGGGSFGGGAGRGGF
                     GGGSFGGGFGGMGGGSSHGGGGGRGR"
     CDS             6291..7496
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: PALP"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg249_8"
                     /sec_met_domain="PALP (E-value: 8.5e-94, bitscore: 304.0,
                     seeds: 146, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLTLDKIYHAAFVLKDVARKTDLIEAPKLSKDCQLYLKTENLQAT
                     GSFKVRGAYYKISQLSEEESAKGVIACSAGNHAQGVALAATRRGIRSIVCMPDGAPLMK
                     VENTKNLGAEVCLVPGTYDEAHDKAVQLQKEYDMTFIHPYDDEQVIAGQGTIGLEILDQ
                     LPDVDAVVVPVGGGGLISGIAFAIKTLRPEVKVYGVQAEGAPSMYRSLHEHKYQTLKAA
                     STFADGIQVKTPGELTYQLCEQYVDDIVTVTEDETAAAILSLMENQKLVAEGAGAVPVA
                     AVLFHKLPVEGKKVACVISGGNIDVNILNRVITRGLVMSGRKANLTIALEDKPGQLKKV
                     AEVVSRCGSNVVSVQHDGSDPNMPISSCFLKLTLETRDAAQIEQIRTELTKAGFQLVSE
                     RV"
     CDS             7684..8058
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Ribonuc_L-PSP"
                     /gene_functions="regulatory (smcogs)
                     SMCOG1038:Endoribonuclease L-PSP (Score: 150.2; E-value:
                     8.6e-47)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg249_9"
                     /sec_met_domain="Ribonuc_L-PSP (E-value: 1.8e-47, bitscore:
                     150.2, seeds: 29, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKVVSTTNAPAAIGPYSQALDLGNMVFVSGQLPVDPATGTMADTV
                     EQQAAQSLANLKAILAEAGLSMNNVVKTVIFLADINDFAAVNAEYAKAFAEPFPARSCV
                     QVAAIPKGAKLEIECIAVRD"
     CDS             complement(8146..9363)
                     /locus_tag="ctg249_10"
                     /transl_table=11
                     /translation="MKLREWNAHLHGLVVFRALLNDPVVAKLLDLTDRMEAGCSSYGPV
                     CDAVAAFEAALFEYTTNWGSYLSNAVLEAETICVRQAAAGQLDALLQSALDSELQFLQQ
                     LCGLTLDELFQTAYSEQAQRPELAFLPRWQTCELDLAAAYTQRMSEVGKKGYGMFAKHH
                     VFTVENGQLVPVKYPDPQRLSELPGYEKEREKVIANTKALLAGMPANNVLLYGDAGTGK
                     SSAVKAIANEFAPEGLRLVEVKKNQLYQIPDLMDKLAANPLKFILFIDDLSFTANDDNF
                     AALKAILEGSVGGRAQNIAVYATSNRRHLIKETLSDRTGDDIHEADTRQELMSLSARFG
                     LTVTFQRPEKARFETILEELAKQHNIQMPTEQLLLKAEAFALRAGGRSPRVAKQFIEQC
                     EAGVQK"
     CDS             9890..11554
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg249_11"
                     /sec_met_domain="TPP_enzyme_C (E-value: 2.2e-51, bitscore:
                     163.5, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQLNGSQIFVEVLCEQGVDTLFGYPGGAVLNLYDELYKNADRITH
                     VLTAHEQGAAHAADGYARATGRTGVVLATSGPGATNLVTGIATAYMDSVPMVAFTGNVP
                     TSSIGKDGFQEAYIEGITVPITKHNFTVRRVEDLADTMRAAFRIAQSGRKGPVLVDIPK
                     DVTAAVCEFTPKQPEPIRTVTTYNEEQVHWAADLINAAQRPLVYFGGGVRSAASCQPLR
                     DLLHKAEIPATYTLMAAGVVPYGDPMNLGMLGMHGCYTSNRAVAECDVLIAVGTRFSDR
                     VALNPKTFAKNATIIQIDIDASELGKNVDVDLSIVGDAAYVLNAMLPQIKPAKHPDWMT
                     MIQSWQAQDYHPVSDPTRLMPHQVIGEVCNQCGPDAVYVTDVGQHQMWAAQYLRHTKSR
                     GFITSGGLGTMGFGYGAAIGAQMALGRQQRVVMFTGDASFHMNLNEACTAVSYELPIIT
                     VIFNNSVLGMVRQWQTSFYGKRYSQTDPHRKTDFVKLADGFGLKGYRCTNLPEFQEAFA
                     DALQQKGPTWIECIIDKDEKVLPMIPGGGDINDIIME"
     CDS             11570..12133
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg249_12"
                     /sec_met_domain="ALS_ss_C (E-value: 1.7e-28, bitscore:
                     88.6, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKSDQRRVISLLVDNQSGVLARVSSLFCRRGFNIDSLTVSATNDP
                     AVSRITVTITSDEKALQQLVLQTERLEVTRQVFVLDSEKALERELLLLKVESDVHNRTE
                     LREIACIYKAKIIDLSPDSMVFELIGRPDKLDAFLKMFEGYNILEQCRTGVTALERGGM
                     HQHMQKPPQEVRSVQLPPPGERRA"
     CDS             12233..12805
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg249_13"
                     /sec_met_domain="IlvN (E-value: 1.3e-75, bitscore: 242.3,
                     seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAIKKYYDSDCNLGVLDGKTVAVIGFGSQGHAHSENLAESGVNVV
                     VGLRKGSAHWAKASEFAATHENFKVMEVEEAAKAGDVVMMLVPDELCADIYNTQVAPYM
                     TEGKALAFAHGFNIHFKTITAPKNVDVIMIAPKGPGHIVRRLYTEGEGCPSLICVEQDY
                     TGKAKDIALAYASGIGAGRAGILQTTFK"
ORIGIN
        1 ataaaattgc aaccaatttg caatttggta ttgcaattgg gaaggatatc gtgtataatc
       61 ttccctgcac gaaaatgcaa actgattgca aattgttaag agacgacccc atgcgggtct
      121 ttggagcgat tatttatgga actgtttctg gatgttttgg gcgaaacctt ggtggatacc
      181 gccaagatgc tgccctttct gtttctggcc tacctgctga tcgagtatat cgagcaccgc
      241 cacggcgagc gcatcgaggc gctgctggcg ggcggcgggc gctggggtgc tgtgccgggc
      301 gcggtactgg gctgtgtgcc gcagtgcggc ttctccgcca ttgcgtccaa cttctacgcc
      361 tcccgggtca tcacgctggg cacgctgatg gcggtgtacc ttgccaccag cgatgaggct
      421 atcccgctgc tggtctccat gcccgcctac tgggataagc tggccgtcct gatggtcatc
      481 aaggtggtgt acgccatcgt ggtgggcttt gtgctggatt ttgtgctgcg gggcgtgctg
      541 cccaaaggtc tgcggggcgg ctacaccggc catgcagacg aggtggactg ccacgaggag
      601 cacagcgatg ccgagggcaa cgaaaagccc atctggcagg cggcgctgcg ccatacgctg
      661 gagatctttg tgttcatctt cgccttcagt ctggtgttcg gcatgatcgt ggagggcgtg
      721 ggcgaggacg tattcgccga aatgctgggc ggcatgggct tcttccagcc ggtggtggcg
      781 gccctggtgg ggctgatccc caactgcgcc gccagcgtgc tgctgaccca gctgtatgtg
      841 gagggcgcgc tgcgcttttc cagccttgtg gcggggctgt gcaccggtgc gggtgtgggc
      901 ttggctgtgc tgtggcgcgc caacccctcg tggaagcaga acctcttcat caccggcctg
      961 acatgggccg ccggtgcctt tgtgggcgtg gccatgcagg tggtcgtggc ggtgtttgcc
     1021 tgataaggaa agatattttg aatttcggga cagtgggatg cctgcgggta ttctgctgtc
     1081 ccatttttct tttctccctc tcccgctgga ctttgaaatg tgttatactg ggggaaaacg
     1141 atgcacacag gagagatgac catgcaatat aagattctgg caagcgatta cgacaacacg
     1201 ctgatgccct ttggcgaggc aaagccccgc ccggcggtgg taaaggcggt aaaaaagctg
     1261 caagccgccg ggggcaagtt cgtgctcagc accggccgct cctacccggg catccgggac
     1321 aaaaaccagc tgggcggcat ccggtatgac tacgccatta cctgcaacgg cgcctgcgtg
     1381 gtggacagac agggcaacgt aatagccgag catccgctta ccagcgagga gatgtatgtg
     1441 ctggtggatt tttgcgagga ttataactac ccgctgcaat tcaacttccg ggatgcctat
     1501 tacgcctact gcgagtacga gtatctgcac accggctatc agatgatgaa cagccccggg
     1561 ctggactgcg tggacggcga agatcaggat cggcatctag tggatatgcc ccacgccgcc
     1621 tttgccgcca tgccgccgca ggaagtggag cgcttccacg aaaaatacgg ctaccttggc
     1681 ctgcactgga tgcagacggg cgcgcagaac gcggacggct actgctacta cgatatcgtg
     1741 cgcggcggca tggataaggg cgtagggctt gccgacctgt gtgcacagat ggggcttacg
     1801 ctggcagatg ccgtggctgt gggtgattct gccaacgatg tgggaatgct gaaagtcgcg
     1861 ggcctgagtg cctgcatggc aaacggcacc ccggacgcca aggccgctgc cgaccggatc
     1921 atcggggacg tgcgggagga tggcgtggcg gcgctgatcg aggagctgtg gttcaacggc
     1981 ccccgcgcgg agccctccgg caaagatttt ggctccgcat ggggcaatat tgaaagcgca
     2041 ggcggcagct tatgagcttt gcaccggtgt acgatgaccg cagtcgggcg ctgattttag
     2101 gcacatggcc cagccccaaa agccgggaga tggcttttta ctacggccat ccgcaaaacc
     2161 ggttctggcc gctgctggcg gcgctgaccg gggagccgct gcccgtgcgg gaggatatcg
     2221 cggccaaaaa gcagctgctt ttgcgccacg ggctggcgct gtgggacacg ctggaaagct
     2281 gtacgatcac cggcgcatcg gatgcctcca tccgggatgt ggtgcccaac gatatcgccg
     2341 ggctgctgcg caaagcgccc atccgggcgg tgttctgcaa cggtgccaca gcttaccgta
     2401 tctacacaaa atatcagcag ccgcttactg gcatcccggc tgtccgtctg cccagtacaa
     2461 gccccgccaa cgccgcctgc agccccgctc ggctggagga gctttggggc gctgcgctgg
     2521 cggactggat cgtaaaatga tgacaaggct gtaaattctt ttgcgggata cttgcgtttt
     2581 tttgcggacg ttgtattatg gatatcataa ggggcgcact gccccggaca aggagaaatg
     2641 accatgagca agatcatccg cacccaaaag cccagcgtgc tgccttttta cgccatggcg
     2701 ctggtgttcg tggtgctgtg cgcggtgctg ccggtataca aattatgggc gctgctggtg
     2761 gcgctgggtg gtgccgccgt ggcctttggc gtggcaaaaa agaactgccc gccccgggtg
     2821 gtggagcacg aggtaccctt ccacaccggt gtggaggatg tggaccagat gctgaccgat
     2881 atccagcaga agctggacac cctgcacgcg ctgaacgagg ctttgcccga cccgcagctg
     2941 tccgccgcca tgacccgcat ggaaaaggca ggacgctcca tcgtggaagc ggtggaagca
     3001 aaccccgcca aggcaaagca ggtgcgccgg tttgccaact actatctgcc ggacgccgta
     3061 aacgttttgc agcagtacgc aaagctggca aagcagggtg tgcggggcga gaacgccgcc
     3121 gccatccgcg ctgaggtgga gcacaacgcc gcctccattg ccacggcttt tgaaaaccag
     3181 ctggatgccc tgtatgcggc agagagcatg gacctgtccg cagacctgac cgttttgcag
     3241 aatatgctga aaggacaggg tctgagcaag taaaaccaga atatcccctc gggattttga
     3301 aaggaaggaa tcacttatgg ctgacaatac tctgaacttt gatctggatg cccccgcagt
     3361 gcccaccctg acgctggacc ccacccccgc tgctgtgccg caggaggaaa agcccgccgc
     3421 tgcccctgcc ccggaggcac aggtgaacct gacccccgag gagcaggcca tggtggatca
     3481 gtttgcccag aagatcgata tcaccaacag ccagcaggtg ctgcagtacg gctctgcctg
     3541 ccagaagaag atcggcgatt tctccgaagc agccctctcc aaggtgtcca ccaaggatct
     3601 gggcgaggtg ggcgatatga tcaccgacct cattggcgag ctgaagagtt ttgatgccaa
     3661 cgaggagcag cagaagggca ttatgggctt tttcaagaag aaaaccagcc agctggatgc
     3721 cctcaagacc aagtacgaca agaccgagac caacgtggaa aagatccagt ccatgctgga
     3781 agcccatcag gtgcagctgc tcaaggacat cgccatgctg gacaagatgt acgagctgaa
     3841 catggcatac ttcaaggaac tgagtatgta tatccttgcc ggcaagaaaa agctggccga
     3901 tgtgcgtgcc aacgaactgc agcaggccat ggataaggcc aaggtctccg gtctgccgga
     3961 ggacgcacag gctgcccgcg accttgccga ccagtgcgag cgctttgaga aaaagctgta
     4021 cgatctggaa ctgacccgca acatcagttt gcagatgggc ccccagatcc gtctgctgca
     4081 gaacaacaac accatgatgg cagaaaagat ccagtccacc attgtgaaca ccatcccgct
     4141 gtggaagaac cagatggtgc tggcactggg tctggcacac agccagcagg ccatgcaggc
     4201 agagcgcgct gtgaccaaca tgaccaacga cctgctgaag aagaacgccg aggcgctgaa
     4261 gctgggcacc atcgagaccg ccaaggagag ccagcgcggc atcgtggata tcgagaccct
     4321 gcagcagacc aacaagagcc tgatcgagac gctggacgaa ctgaacaaga tccagagcga
     4381 gggccgcgca aagcgcgccg ccgccgagca ggagctgacc cgcatcgagg acgaactgaa
     4441 aaccaaaatg atggagatcc ggagctgaaa tggcaaacgc tgatttttct cagaacaaac
     4501 aaacagttcc cggcggcttt gacgcgggca gctaccgcga aaaagcaaag ccggagcagg
     4561 tcgtaaggct gacgccccgc cagcagaagc tggccgcact ggaagcaaag ctgcccgctg
     4621 cgctttccac ccgggcggcg gcgctggcct tgagtgtagt ggtgatgctg gccgcctttt
     4681 tcggctttgg cagcgccaag ctgcggggca agtacaacac tgcccgtcag tggttcaccg
     4741 caggggtcgc cgccgacaac ggttataacc tgagcgagga gctgaccacc cgggagaata
     4801 cggcggcgaa tattctgacc actgcctcca acacccttgg cgcagacagc gccgaggtgc
     4861 tggctgcaca gacggcgctg aacgatttct ccgcttgtct gcaggcggtg cagaacggcg
     4921 gtaaaagcca gtcgctgacc tcgctgccct attatcaggg cagcacgatg cacgcgctgt
     4981 atcaggccga tcaggcactg ggcgctgcca tcgaccagct gtatgcaaaa ttgcaggagc
     5041 aggccgcaga ccccatgaag atggatgcgg tgcagggaca gtacggccag ttcaacagtg
     5101 cggccaccat cattggtacc ttgcagtaca atacggcggt gtatgaatat cagaaggatg
     5161 tcggcggctt cccggccggt gtgctgggcg ctttgtccgg cgtgaaggag gttgagccct
     5221 tcgcatgaaa aactttgcaa aacgcatcag cgcactggtg ctggccgtgg tggtcagcgc
     5281 ggcggtgctg tgcccggcgg cctttgccgc tcaactgccc agcctgccca aggatcagtg
     5341 cgtggtggat ggtgccggtg tgctgagcag cagcactgtg cagaccatca ccgaactgaa
     5401 cgcccagctg gaatccagct gcagcggcgc gcagatcggt gtactgacag tagaatacac
     5461 aggcaatgat tccacagagg attacgccac acaggctttc aacgcgtggg gcatcggttc
     5521 gtcctctaag aacaacggcg ttctgatttt gctggtgatg gaatcggcgc agtacgcgga
     5581 cggcgactac tacctgacct acggcgacgg tttccgcaac accacgctgg caaagcagtc
     5641 cagcgccatc gcccagacga tggaggatca gtttgccgca aaggattatg acggcgcagt
     5701 gaccacttgt gcccgcaacg tggcaaacac catcgcggat atttacgggg tcagcctttc
     5761 cggcagcgcc ggcaacggca gcaccgtgca gcccgggtat cagggcgggc agagcagcgg
     5821 cggcagcgcc ctgaccgaca tcctgaccct tgtggtcagc gttgtgctgc ttatcgtcat
     5881 tatccggtcg atggcctatg tttttgccag cccctgcggc tggctgtggt gcttcggcgg
     5941 gccccggcct ccccgtggac ggcggcgcgg cccgcataac ccgccgcccc cgccgggcgg
     6001 cttctacggc ggctttggcg gcatgggcgg cggctccttc gggggcggtg ccggccgcgg
     6061 cggtttcggc ggcggcagct ttggcggcgg cttcggtggc atgggcggtg gttccagcca
     6121 cggcggcggc ggtggccgtg ggcggtaatg agaataaaaa gagaaaggca gtggctttac
     6181 cattgccttt ctctttttta cgccttttat cgtgaatgaa attcatttga caaaacaatt
     6241 tttgtaactt atactggatg acatcacgaa aaataaagga agtatctgtc atgctgactc
     6301 tggataagat ctaccacgcc gcctttgtgc taaaggacgt agcgcgcaag accgacctca
     6361 tcgaagcccc caagctgtcc aaggactgcc agctgtacct taagaccgag aacctgcagg
     6421 ccaccggcag ctttaaggtg cggggcgctt actataaaat cagccagctt tctgaggagg
     6481 agagtgccaa gggcgtcatt gcctgctctg cgggcaacca tgcgcagggg gtggcgctgg
     6541 ccgctacccg gcgcggcatc cgcagcatcg tctgtatgcc ggacggcgca cccctgatga
     6601 aggtggaaaa caccaaaaat ctgggcgcgg aggtctgcct tgtgcccggc acctacgacg
     6661 aagcccacga caaggccgtg cagctgcaaa aggagtacga catgaccttt atccacccct
     6721 acgatgacga gcaggtcatt gccgggcagg gcaccatcgg cttggagatc cttgaccagc
     6781 tgccggatgt ggacgctgtg gtggtgccgg tgggcggcgg cggactgatc tccggcattg
     6841 cctttgccat caagactctg cgcccggagg tcaaagtgta cggcgtacag gccgagggtg
     6901 cccccagtat gtaccgcagc ctgcacgagc acaagtacca gaccctgaaa gcagcttcca
     6961 cctttgcgga cggtattcag gtcaagaccc cgggcgagct gacctatcag ctatgcgagc
     7021 agtatgtgga cgatatcgtt accgtgaccg aggacgagac cgcagcagcc atcctctccc
     7081 tgatggaaaa ccagaagctg gtggccgagg gtgcaggcgc tgtgccggtg gcggcagttc
     7141 tgttccacaa gctgccggtg gagggcaaaa aggtggcctg cgtcatctcc ggcggcaaca
     7201 ttgatgtgaa tatcctgaac cgcgtcatca cccgcggtct tgtgatgagt gggcgcaagg
     7261 caaacctgac catcgcgctg gaggacaagc ccggccagct gaaaaaggtg gccgaggtgg
     7321 tatcccgctg cggcagcaat gtggtgtcag tgcagcatga cggctccgac cccaatatgc
     7381 ccatctccag ctgcttcctc aagctgacgc tggagacccg cgatgccgcc cagattgagc
     7441 agatccgcac cgagctgacc aaggccggct tccagctggt cagcgagcgg gtgtaaactt
     7501 catcgtttgc aagagcgaaa gccttccccc ggacggagga aggtggatgc gagcgtagtg
     7561 agcagacgga tgagggcgca ggcaagcagc agcttacggg aaattacccc ctcatccggc
     7621 tctatccgaa gaaaaaagcg aatttgttct aaatttaatg taatataaag gagaaaatat
     7681 accatgaaag tcgtatctac caccaacgca cctgccgcca tcggccctta cagtcaggca
     7741 ctggatctgg gcaatatggt gtttgtttcc ggtcagctcc cggtagaccc cgccaccggc
     7801 accatggccg ataccgtgga gcagcaggcc gcccagagcc ttgccaacct gaaggcgatt
     7861 ctggccgagg cggggctttc catgaacaac gtggtcaaga cggtgatctt tctggccgac
     7921 atcaacgatt ttgccgcagt gaacgcagag tacgccaagg cctttgccga gccgttcccc
     7981 gcccgcagct gcgtgcaggt ggcagccatc cccaagggcg caaaactgga gatcgagtgc
     8041 atcgccgtgc gggactgagc gaataaagat aagaaaagcg ggacaccaaa gcatccgcag
     8101 atgctccggt gtcccgcttt ttgataacgt ttaaaactgg tgcgtttact tctgcacccc
     8161 ggcctcgcat tgctcgatga attgcttggc cacccggggg ctgcggccgc cggcacgcag
     8221 agcgaaggcc tcggccttga gcagcagctg ctcggtgggc atctggatgt tgtgctgctt
     8281 tgccagctcc tccagaatgg tctcgaaccg ggccttctcc ggccgctgga aggtgaccgt
     8341 caggccaaac cgggcagaaa ggctcatcaa ctcctgccgg gtgtcggctt catggatgtc
     8401 gtcgccggtg cggtccgaga gggtttcctt gatgaggtgg cggcggttgg aggtggcgta
     8461 caccgcaatg ttctgggcac ggccgcctac gctgccctcc aaaatggcct tcagggcggc
     8521 aaagttgtcg tcgttggcgg taaagctcag gtcgtcgatg aacaaaatga acttgagcgg
     8581 gtttgccgcc agcttatcca tcaggtcggg gatctggtac agctggttct tttttacctc
     8641 taccagccgc agtccctcgg gcgcaaactc gttggcaatg gcctttaccg cgctggattt
     8701 gccggtaccg gcgtcaccgt acagcagcac attgttggcg ggcatcccgg ctagcagtgc
     8761 ctttgtgttg gcgatcactt tttcccgctc cttctcgtag ccgggcagct cggaaaggcg
     8821 ctgcgggtcg gggtatttta ccggcacaag ctggccgttc tccaccgtga atacatggtg
     8881 ctttgcaaac ataccgtagc cctttttgcc cacctcgctc atgcgctggg tgtaggcggc
     8941 ggcaaggtcg agttcacagg tctgccaccg gggcaggaaa gccagttccg gccgctgcgc
     9001 ctgctccgag taggcggtct ggaacagttc gtccagcgtc agaccgcaca gctgctgcaa
     9061 aaactgcagc tcgctgtcca aggcgctttg cagcagcgcg tccagctgcc cggcggcggc
     9121 ctgtcgcaca cagatggtct cggcctccag cacagcattg ctcaggtagc tgccccagtt
     9181 ggtggtgtac tcgaacaaag cggcctcaaa ggcggctacg gcatcgcaca ccgggccgta
     9241 ggaggagcag cccgcctcca tgcggtcggt caggtctaaa agctttgcca caacagggtc
     9301 gttcagcagg gcacggaaca caacaagccc atgcagatgg gcattccatt ctcttaattt
     9361 cataggtcga tcccttttcc tctccattgg cacataccct acaaaacgca ggtacgcgga
     9421 tatcaaaagt atacagcggt tcgggcgggg atgcaagggg tgttaaaaat gcttcatctt
     9481 tgggctgatt caggttacaa attgtcgatt gacaaaagcc cggtttatag tataatttac
     9541 atcaacaaat gcgcagatgg gaaaaagtac cacacgatcc ccactgttca gagagctgcc
     9601 gtctggtgca aggcagtcag cgtttcgtgc ggaaaatcat cccggagcag cctgcccaac
     9661 gggtgcaaaa cccttgtaag cagcgccggt tgcagccgtt accgtgcagg gctttgttgg
     9721 aagcccgtga gagggtgtgc acagcacgcc aacgagagtg gtaccgcaga gagcttgatg
     9781 ttacaaggtc tttgtctctt gaagaaagca ggggacaagg gctttttctt tttcaaaagc
     9841 tctccctgag ggaatggata agaagtggaa caggaatagg agcaacacca tgcagttgaa
     9901 tggttctcag atctttgtag aggtcctgtg cgagcaggga gtggacactc tttttggcta
     9961 ccccggcggc gctgtgctga atctttacga cgagctgtat aagaatgccg accgcatcac
    10021 ccatgtgctt accgcccacg agcagggcgc agcccatgct gcggacggct acgcccgcgc
    10081 caccggccgc accggcgtgg tgctggctac cagcggcccg ggtgccacca atctggtcac
    10141 cggcattgcc accgcctata tggactcggt gcccatggtg gcctttaccg gcaacgtgcc
    10201 caccagcagc atcggcaagg acggctttca ggaagcgtac atcgagggca tcacggtgcc
    10261 catcacaaag cataacttca cggtgcgccg ggtagaggac ttggctgaca ccatgcgggc
    10321 agccttccgc attgcgcaga gcggccgcaa gggcccggtg ctggtggata tccccaagga
    10381 cgtgaccgca gcggtgtgcg agttcacccc caagcagccg gagcccatcc gcaccgtaac
    10441 tacctataat gaggagcagg tgcactgggc ggcagacctc atcaacgccg cacagcgtcc
    10501 gctggtgtac tttggcggcg gcgtgcgcag cgcagccagc tgccagccgt tgcgggatct
    10561 gctgcacaag gcggagatcc ctgctaccta caccctgatg gccgcaggcg ttgtgcccta
    10621 cggcgacccg atgaatctgg ggatgctggg gatgcacggc tgctacacct ccaaccgggc
    10681 ggtggcagag tgcgatgtgc tcatcgcggt gggtacccgc ttttccgacc gcgtggcgct
    10741 gaaccccaag acctttgcca agaacgccac catcatccag atcgatattg acgccagcga
    10801 gctgggcaag aacgtggatg tggatctttc catcgtgggc gatgcagcct atgtgctgaa
    10861 cgccatgctg ccccagatca agcccgccaa gcacccggac tggatgacga tgatccagag
    10921 ctggcaggca caggattacc accctgtgtc cgaccccacc cggctgatgc cccatcaggt
    10981 catcggcgag gtgtgcaacc agtgcggccc tgatgccgtg tatgttaccg acgtgggtca
    11041 gcaccagatg tgggcggcgc agtacctgcg ccacaccaag agccgcggct ttatcaccag
    11101 cggcggcctt ggcaccatgg gctttggcta cggcgctgcc attggtgccc agatggcact
    11161 gggacgccag cagcgtgtgg tgatgtttac cggtgacgcc tccttccaca tgaacctgaa
    11221 cgaagcctgc accgccgtca gctacgagct gcccatcatc acggtcatct tcaacaactc
    11281 ggtgctgggc atggtgcgcc agtggcagac cagcttttac ggcaagcgtt acagccagac
    11341 cgacccccac cgcaagaccg attttgtcaa gctggcagac ggctttggcc tgaagggcta
    11401 ccgctgcacc aatctgccgg agtttcagga agcctttgcg gatgccctgc agcagaaggg
    11461 ccccacctgg atcgagtgca tcattgacaa ggacgaaaag gtgctgccca tgatccccgg
    11521 cggcggcgat atcaacgaca tcatcatgga ataaggagga cacagcatca tgaaatctga
    11581 tcagcgcagg gtcatcagcc tgctggtgga caaccagagc ggcgttctgg cccgggtgtc
    11641 cagcctgttc tgccgccgcg gcttcaatat cgacagcctt acggtgtccg ccaccaacga
    11701 cccggcagtc agccgcatca cagtgaccat taccagcgat gaaaaggcct tgcagcagct
    11761 ggtattgcag accgagcggc tggaagtcac ccggcaggtg ttcgtgctgg acagcgaaaa
    11821 agcgctggag cgggagctgc tgctgctcaa ggtggaatcg gacgtgcaca accgcacaga
    11881 gctgcgggag atcgcctgca tctacaaggc aaagatcatt gatctttccc cggacagcat
    11941 ggtgtttgag ttgatcggcc ggccggacaa gctggacgca tttttgaaaa tgttcgaggg
    12001 ctacaacatc cttgagcagt gccgcaccgg cgttaccgca ctggagcgcg gcgggatgca
    12061 ccagcatatg cagaagccgc cgcaggaggt gcgctccgtc cagctgcccc cgccgggcga
    12121 aagacgggca taaatcacat tgcttttccg ctcagggtga gcgaaagata gaacagagca
    12181 tacaagaccg gaagataaac caaccagaaa aggtaaaagg agactaacga ttatggctat
    12241 caagaaatac tacgattccg actgcaacct cggcgtgctg gacggcaaga ccgtcgctgt
    12301 catcggcttc ggcagccagg gtcatgcaca ctctgagaat ctggccgaga gcggcgtcaa
    12361 cgttgtggtg ggtctgcgca agggctctgc tcactgggca aaggcttctg agttcgctgc
    12421 cacccacgaa aacttcaagg tgatggaagt ggaagaggct gccaaggctg gtgacgttgt
    12481 catgatgctg gtgcccgacg agctgtgcgc cgatatctac aacacccagg ttgctcccta
    12541 catgaccgag ggcaaggcac tggcctttgc acacggcttc aacatccact tcaagaccat
    12601 caccgctccc aagaacgtgg acgtcatcat gatcgctccc aagggccccg gccacatcgt
    12661 gcgccgcctg tacaccgagg gcgagggctg cccctctctg atctgcgtgg agcaggacta
    12721 caccggtaag gccaaggaca ttgctctggc ctatgcttcc ggcatcggcg caggccgtgc
    12781 aggcatcctg cagaccacct tcaagg
//
