LOCUS       c00243_gnlPro..        14092 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|BHAHOFNO_243.
ACCESSION   c00243_gnlPro..
VERSION     c00243_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 00:45:53
            Original ID  :: gnl|Prokka|BHAHOFNO_243
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14092
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14092
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2:4092]"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      3..4092
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
     cand_cluster    1..14092
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /kind="single"
                     /product="Others_HGD_unassigned"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14092
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Others_HGD_unassigned"
                     /region_number="1"
                     /rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D, HleuD1,
                     HleuD2, HleuS1, HleuS2, Lactoyl-CoA1, Lactoyl-CoA2]) and
                     minimum(1, [ACP_syn_III, ACP_syn_III_C, AcetylCoA_hyd_C,
                     AcetylCoA_hydro, Acyl-CoA_dh_1, Acyl-CoA_dh_2,
                     AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG, Biotin_lipoyl,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_6_Glutaconate, CoA_transf_3, ECH_1, ECH_2, ETF,
                     ETF_alpha, FGGY_C, HCDH, HCDH_N, Hacid_dh, Hacid_dh_C,
                     Mal_decarbox_Al, Peptidase_M22, Peptidase_M23, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and not (minimum(2,
                     [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /tool="gutsmash"
     CDS             complement(3..1061)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: HGD-D"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg243_1"
                     /sec_met_domain="HGD-D (E-value: 4.7e-22, bitscore: 69.1,
                     seeds: 370, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEYHYPKFTPEMKKTHTILIPNMAVTQFRLMEYALRCEGYKCELL
                     GNCGSAVAQLGLKYVHNDTCYPALLVIGQFLDALNSGKYDLEHTALLITQTGGGCRASN
                     YIHLLRKALVKAGYPQIPVASLNFSGLEKDSGFQMTLPLARKCIACIFYGDMLCALRNQ
                     VAPYENEKGAADRMMDRWIARLGRALLAGKGFTSREMKHTFPLIAKEFATIPVTRVPKV
                     KVGVVGEIYVKYSPLGNNDLQKFLESQDCEVNFPGLMGFVQYCAFNMGEDHVLYGGKLA
                     VKVGTDQFLNWLDSVERVMLKAETDAGFYAPGPFKELVEKPKGVISLGAKMGEGWLLTA
                     EMIELVQGGYGNI"
     CDS             complement(1153..4092)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: HGD-D"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: BcrAD_BadFG"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg243_2"
                     /sec_met_domain="HGD-D (E-value: 1.3e-15, bitscore: 47.9,
                     seeds: 370, tool: rule-based-clusters)"
                     /sec_met_domain="BcrAD_BadFG (E-value: 4.2e-39, bitscore:
                     124.6, seeds: 18, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VRVGLDIGSTTIKCVVLGEHDELLYSTYERHYSHILEKAQELLRR
                     IDAEHLHGRKALLSISGSAGMGLADSCGVPFVQEVFSTRVAVKRFMPKTDCVIELGGED
                     AKILFLTNGTEVRMNGSCAGGTGAFIDQMATLLKMSAEEMNKAAEQAQRTYTIASRCGV
                     FAKSDVQPLINQGARTEDIAASIYKAVVNQTIAGLAQGRPIKGNILYLGGPLTFSTVLR
                     KSFDEALNVTGTCPENSLLYVALGAALYADKEFVLTEVADALDKYAATATYASEPPLFA
                     SKEEYEAFHARHMSHSVPRVAFSAHCGPVHIGIDSGSTTVKLVVVDEKSQILYTNYQPN
                     LGNPLPLIREQLLKIYKEHPGLQVASVTTTGYGEELVKNAFRCDYGLVETVAHFTAAKY
                     FMPDVDFIIDIGGQDMKCFKIEDGAISNIFLNEACSSGCGSFLQTFAQALGYDVKEFAA
                     LGLFADRPVDLGSRCTVFMNSSVKQAQKDGASIENISAGLSISVVKNALYKVIRASSPE
                     ELGRKIVVQGGTFYNEAVLRAFEKEMGVEVIRPDIAGLMGAYGAALYGLRQSHKNNQTT
                     SAMMDEQELEKFAQQVVSVKCGGCGNHCQLTVNTFADGRKFISGNRCDKPVTGKSEDNS
                     LNLYAYKQQLLASYKPVPGKRGSIGIPMCLGFYELLPFWYAFWTSLGFAVHTSPVSTRG
                     LYLAGQATIPSDTACFPAKLSHGHIKALSQMQLDAIFYPCLTYNVDEGLGDNHYNCPVV
                     AYYPEVLAGNCPELEGKKFIYDYVGIHRPKDFVHKMAKEVLPKYFGGISEREVQAAADA
                     AYAEYEAHMAKIRVKGSEIIDEARRQGKRIIVLAGRPYHVDPEVNHGIDHLITRHGAAV
                     VTEDSISNRVQKFPTSVLNQWTYHSRLYAAAKYCTTQKDMDLVQLVSFGCGVDAITTDE
                     TREILQRGNKLYTQLKIDEITNLGAVNIRLRSLFAALDERDEAAAEKSE"
     CDS             complement(4541..5317)
                     /locus_tag="ctg243_3"
                     /transl_table=11
                     /translation="MSTKPISPTAATRFDLSAAALHILAMALMLMDHLWATLLPAQEWL
                     TCAGRVAFPIFAFMAVEGYFHTHDLKKYTLRLLLFALLSEIPFDLMYGGTWLYPVHQNV
                     IWTLLLGILGIHLMETVRKKQKTGLYLLVSALVVVAGAVLGTLGMVDYYGAGVLTVFIF
                     YFFHGHGRKWWCLLGQLAALYWVNVELLGGLMYPIQLFGMDFELCQQGLALLALVPIWL
                     YRGRQGYHSKPFQYACYAFYPVHMLLLVLVLNFVNR"
     CDS             complement(5998..6636)
                     /locus_tag="ctg243_4"
                     /transl_table=11
                     /translation="MNLKEAFRYQNKLQSLLDEAQGILDCDANVTKVANTYLRHKVMPE
                     AEDETVMDVAQTEYAEQITDVARFMLYLLEEKSRLFAAIRKAKDSLDMDMDSEVSLNAA
                     RQSIARTFKRMNDLRSSEQLLSGGGTGYRFNAEGNQISYCCDVKRVTTINYDRKVIHAA
                     LSKLNRQADETSNRLDLCLVTSKVDYTVPFDVNASFAEAFETYLENVQN"
     CDS             complement(6797..7051)
                     /locus_tag="ctg243_5"
                     /transl_table=11
                     /translation="MLRIEYFDKERFMNQLSASHGSVLLHLDNGKTCDLKKDATARSML
                     QMMDTAPKKGFDLTVTDPADVTGFLRYMLEAGRTERVAG"
     CDS             7321..8253
                     /locus_tag="ctg243_6"
                     /transl_table=11
                     /translation="MAYQTSCASYTSGRVGLSSATAVVADAAGREQTQHGSPLFPIACY
                     AEDLSCFSVAWHWHEEFEFILAALGPIHVDVNKTRLTLQTGQGVFINSGALHAVEPAEG
                     RALLHSGVFQPRLVGGMDTVFWQKLIRPLLQPGTPPFFLLDEAVPWQRQVLLCLREAWK
                     GVADEPFDYENRVRYHLTAALRLLITQCVSGKVKVSEQEQIASERMKQMLRYVEEHYAE
                     ELTVEKLADCVALSESACLRSFRQFLGITPIQYVKQFRVEKAAELLRSTRLKTGEVGLE
                     CGFSDASYFIKTFREIKHCTPREYRIRFC"
     CDS             8788..9375
                     /locus_tag="ctg243_7"
                     /transl_table=11
                     /translation="MLWVGCSERTTPGRCRNSSGRMPTQHGLRRTSNTRFSSLMNRHVW
                     VGSNSKPSAKNSIHASRTVSAPPSTGPMDFMEEWIRMVSLPVSPIAARSCLRSAFVYAM
                     SFLLFGHFVCTQFTAFCAAKQARTQKRQTPCCICRRRAGICGVCALAAFLVKSCIQHII
                     SQRYRETSTAPCNYSNLTVVSCFLCAFGTTVT"
     CDS             9573..10274
                     /locus_tag="ctg243_8"
                     /transl_table=11
                     /translation="MATLQHTDELYHILEDEICALKILPGEALSENQLCKRFGVSRTPI
                     RSVLQRLEQNRFVQIIPCKGTIVTAIDTGVVDQLIFQRVAVEGMVFRDFVQSCSPMEIL
                     AVEHLYNMLLEAAAGRSDPENFDFNHFLSCDLAMHEYWFHKTSKEYLWEQMTRPQADYS
                     RFIRLDIVGARNVSSVVSEHAEMLRILREKDLDAIEPLMRTHLYGGVSRMGSKIYSDEY
                     RGYFKLPENKQ"
     CDS             10799..11257
                     /locus_tag="ctg243_9"
                     /transl_table=11
                     /translation="MKKFLKTLVVGLCLFTLLCCALPAAFAADKTSGSKKEENVYAIGM
                     DAQGGICSTVVTYTNLSGKLESTPEQPTMTGYTFDGWYTEPVGGSKVTTSTVFTSDATI
                     YAHWTAKAGTSTVPQPTTQPAATQWQKYVGPALVAGALLTTLLVATMF"
     CDS             11208..11537
                     /locus_tag="ctg243_10"
                     /transl_table=11
                     /translation="LWPVPCLLPCWSPPCSEHCCKHNDTIEERDLTMTTSTMKMPASYS
                     TIEAEEMTYLDGGASNAYQSFLDIGKVFNYIARIFSGASSIINNVNVIYQSFVSLNSLL
                     GSFGK"
     CDS             11942..12481
                     /locus_tag="ctg243_11"
                     /transl_table=11
                     /translation="MADRELRRMHRAELIEIIYALKQSEDQLKAQNAALTAQLQDRQLR
                     LESAGSIAQAALELNNVFAAAQAAADDYLHSVQASLADTNATAANTLSQARSEAKRILE
                     QAQADADSLKAQAQQECDAMTAAAAQKRTQTEADCKAMVERAEQEVQQRWQAFDHKANE
                     LLDQYRSTDGLPSEET"
     CDS             12478..13068
                     /locus_tag="ctg243_12"
                     /transl_table=11
                     /translation="MKKRDIRFASIPSTEEVAAERERLAYQSRYQRVLRSTIYILVVVA
                     AAAVLLATLFLPVLQVSGDSMYPTLNDKDIILLVKSNHIENGELCGFYWQNKLLLKRII
                     GQPGDVIDMDVNGVVSVNGVALDEPYVDALTVGECDIRFPYQVPENRYFVLGDHRATSI
                     DSRSSVIGCVEKSQIVGRVFLRVWPLSSFSLIH"
ORIGIN
        1 acgatgttgc cgtagccgcc ctgcaccagc tcgatcatct cggcggtcag cagccagcct
       61 tcgcccattt ttgcgcccag cgagataacc cccttgggct tttccaccag ctccttgaag
      121 gggcccggtg catagaaccc ggcgtccgtc tctgccttga gcatgacacg ctccacgctg
      181 tccaaccagt tgaggaactg gtcggtgcct acctttacag ccagcttgcc gccgtaaagc
      241 acatgatcct cgcccatgtt gaaggcgcag tactgcacaa agcccatcag accggggaag
      301 ttcacctcgc agtcctgact ttccaggaat ttttgcaggt cattgttgcc cagcgggctg
      361 tatttgacgt agatctcgcc cacaacgccc accttgacct tgggcacccg ggtgaccggg
      421 atagtggcaa attcctttgc gatgagcggg aaggtgtgct tcatttcccg ggaagtaaag
      481 ccttttccgg ccagcaaggc acggcccaga cgggcgatcc agcggtccat catgcggtca
      541 gcagcaccct tttcgttctc gtagggggcc acctgattgc gcagcgcaca cagcatatcg
      601 ccgtagaaga tgcaggcgat acacttgcgc gccagcggga gggtcatctg gaagccgctg
      661 tccttttcca ggccggaaaa gttcaggctt gccaccggga tctgcggata tccagccttg
      721 accagcgcct tgcgcagcag atggatgtag ttggaggcac ggcagccgcc gccggtctgg
      781 gtgatcagca gcgcggtatg ttccagatca tacttgccgc tgttcagcgc atccagaaac
      841 tggccgatga ccagcagcgc cgggtagcag gtatcgttgt ggacatactt cagccccagc
      901 tgtgccacgg cactgccgca gttgcccagc agctcacact tgtagccctc gcagcgcagt
      961 gcgtactcca taagccggaa ctgggtaacg gccatgttgg ggatgaggat ggtgtgggtc
     1021 tttttcatct ccggggtaaa tttgggataa tgatattcca taggttcctc ctatgttgct
     1081 ctaaacaaga tagtccccgc aaaagcttcc cctcgccggg gggaagccct tcagcctatc
     1141 tcagggtttc ttttattctg acttttctgc ggcggcctcg tcccgctcgt ccagtgcggc
     1201 aaacaggctg cgcagacgga tgttcacggc accgaggttc gtgatctcgt cgatcttcaa
     1261 ctgggtgtac agcttgttgc cccgctgcaa aatctcgcgg gtctcgtcgg tggtaatggc
     1321 atccacgcca cagccgaagg acaccagctg caccagatcc atatcctttt gggtggtgca
     1381 gtacttggcg gcagcataca ggcggctgtg gtaggtccac tggttcagca cactggtggg
     1441 gaacttctgc acccggttgg agatgctgtc ctcggtaacc accgcagccc cgtggcgggt
     1501 gatcaggtgg tcgatgccgt ggttgacctc cgggtctaca tggtaggggc ggcctgccag
     1561 cacaataatg cgcttaccct gacggcgcgc ctcgtcaatg atctcactgc cctttacccg
     1621 gatctttgcc atgtgcgctt cgtactccgc gtaggcagca tcggctgcgg cctgcacctc
     1681 ccgctcggag atgccgccaa agtacttggg cagcacctcc tttgccatct tgtgcacaaa
     1741 atccttggga cggtggatgc ccacataatc atagatgaac tttttgcctt ccagctccgg
     1801 gcagttgcct gccagaacct ccgggtagta ggccaccacc gggcagttat aatggttgtc
     1861 gcccaagccc tcgtccacat tgtaggtcag gcaggggtag aagatggcgt ccagctgcat
     1921 ctggctcagc gccttgatgt ggccgtggct cagctttgcc gggaagcagg cggtatcgct
     1981 ggggatggta gcctgtccgg ccagatacag cccgcgggtg gacaccgggc tggtgtgcac
     2041 cgcaaagcca aggctcgtcc agaaggcgta ccagaagggc agcagctcgt agaagcccag
     2101 acacatcggg ataccgatag aaccgcgctt gccgggcaca ggcttgtagc tggccagcag
     2161 ctgctgcttg taggcgtaca ggttcaggct gttgtcctcg cttttgccgg taacgggctt
     2221 atcgcagcgg ttgccagaga tgaacttgcg gccatcggca aaggtgttga cggtcagctg
     2281 gcaatggttg ccgcagccgc cgcacttgac gctgaccacc tgttgtgcaa atttttccag
     2341 ttcctgctcg tccatcatgg cagaggtggt ctggttgttt ttatggctct ggcgcaggcc
     2401 gtacaaggca gcgccgtaag cgcccatcag accggcaatg tccggccgga tgacctccac
     2461 gcccatctct ttttcaaagg cacggagcac ggcttcatta taaaaggtac cgccctgtac
     2521 cacgatcttg cggcccagct cttccgggct ggaagcgcgg atcaccttgt acagcgcgtt
     2581 cttgaccacg ctgatggaca ggcctgcgga gatattctcg atgctggcac cgtccttttg
     2641 cgcctgcttg accgagctgt tcatgaacac agtgcagcgg ctgcccaagt ccaccgggcg
     2701 gtctgcgaac agacccagcg cggcaaactc cttgacgtca tagcccagtg cctgcgcaaa
     2761 ggtctgcaaa aagctgccgc agccggagga gcaggcctcg ttcaggaaga tgttgctgat
     2821 ggcgccgtcc tcgatcttga agcacttcat gtcctgcccg ccgatgtcaa tgatgaagtc
     2881 cacgtccggc ataaagtact tggcagcggt aaaatgcgcc accgtttcca ccagaccgta
     2941 atcacagcgg aaagcgttct ttaccaactc ctcgccgtag ccggtggtgg taacactggc
     3001 cacctgcagc cccgggtgct ccttgtagat cttgagcagc tgctcccgaa tcagaggcag
     3061 cgggttgcca aggttgggct gatagttggt gtacaaaatc tggctctttt cgtccaccac
     3121 caccagcttg acggtggtag aaccggagtc gatgccgata tgcaccggcc cgcagtgggc
     3181 actaaaagcc acgcggggca cactgtggga catgtgccgt gcgtggaaag cctcgtactc
     3241 ctccttgctg gcgaacagcg gcggctcgct ggcataggta gcagtggcgg cgtacttgtc
     3301 cagcgcatcg gccacctcgg tgagcacaaa ttccttatcg gcatacaacg cagcgcccag
     3361 cgccacatac agcagactgt tttccgggca ggtaccggtc acgttcagcg cttcgtcaaa
     3421 gctcttgcgc agcacggtgc tgaaagtgag cgggccgccc agataaagga tattgccctt
     3481 gatggggcgg ccctgtgcca gaccggctat ggtctggttg accacagcct tatagatgct
     3541 ggcggcgata tcctcggtgc gggcaccctg attgatcagc ggctgcacgt cactttttgc
     3601 aaacacgccg cagcgggaag cgatggtata ggtgcgctgc gcctgctcgg cagccttgtt
     3661 catttcctcg gcgctcatct tcagcagggt agccatctgg tcgatgaaag caccggtgcc
     3721 gccggcacag ctgccgttca tgcgcacctc ggtgccgttg gtcaaaaaca ggatcttggc
     3781 atcctcgccg cccagctcaa tgacacaatc ggtcttgggc ataaagcgct tgaccgccac
     3841 gcgggtggag aacacctcct gcacaaaggg cacaccgcag ctgtcggcta agcccatacc
     3901 ggcagagccg gagatgctga gcagcgcctt gcggccatgc agatgctcgg catcaatgcg
     3961 ccgcagcagc tcctgcgcct tttccagaat atgactataa tgtcgttcgt atgtagaata
     4021 cagcagttca tcatgctcgc ccagcaccac gcacttgatg gtggtgctac cgatgtcaag
     4081 acctactctc accttgtttt tcctcctaag gacaaataac cggaacataa cgccccggct
     4141 gctatggcaa acaagccgtt tgcgacaaag acccgcaacg gcgttttttc tttttagctt
     4201 cccgcattgc gcatctacgt cattttcaaa cagtacgcgt tataaaaaac acagcaaatg
     4261 cgcttttgca tacattatta ttataatcca atcgcgggcg gcattcaatc catgttgtct
     4321 attttacacg aaaaaaatag tattttttgc tcaaaaggct gaactttttg tgaacatgtg
     4381 tcggttttcc cgcaaaaaaa gccgccgcac agcgctttgt gcagcggcct tgtaccggcg
     4441 ggacgatttc gaatggctcc gcatgcgctt tggctatttt cagcggaagt tcctctctac
     4501 gccccacgcg taaaaatgtt tttggagtgc tccgttttcc ttaccggttc acgaaattca
     4561 gcaccagaac cagcagcagc atgtgcacgg ggtaaaaggc gtagcaggca tactggaaag
     4621 gcttgctgtg atagccctgc cgaccgcggt acagccagat gggcaccagt gccagcagcg
     4681 ccagcccctg ctggcaaagc tcaaagtcca tgccgaagag ctgaatgggg tacataagcc
     4741 cgcccagcag ctccacgttg acccagtaca gcgcagccag ctgccccagc agacaccacc
     4801 acttgcgccc gtgcccgtga aaaaagtaga agatgaacac agtcagcacc cctgcgccgt
     4861 agtagtccac catgcccagc gtgcccagca ccgcgcccgc caccaccaca agggcggata
     4921 ccagcaggta cagtcctgtt ttttgctttt tgcgcaccgt ttccatcaag tggatgccca
     4981 gaatgcccaa aagcagcgtc cagatgacgt tctggtgcac cgggtagagc catgtgccgc
     5041 cgtacatcaa atcgaagggg atttccgaaa gcagggcaaa caacagcaga cgcagggtgt
     5101 attttttcag gtcatgggtg tggaagtagc cctccaccgc cataaacgca aagatgggaa
     5161 acgccacccg cccggcacag gtcagccatt cctgcgcggg cagcaaagtg gcccacaggt
     5221 ggtccatcag catcagcgcc atggcaagga tatgaagggc cgctgcgctc aggtcaaagc
     5281 gggtcgcggc agtggggctg attggtttcg ttgacatact cgcacctcgt cttttgtcga
     5341 aattcagttc ctttatctgg aatacgaacg agccccgcaa agaattgcag ccccggtagt
     5401 tcttttcccg ccggggccgg cttgctgctt tattttttct gctgcgaaca ccctagcaac
     5461 aaaaaggtag cgccaaggca gcgccatacc actgccgtag cgtgatcccc tccggtaaca
     5521 aagttcagcg ccgcagcaag aaaaaacagc agcccgatga gataaaacag cttacacctt
     5581 ttcatagctc atacctccgg ttttggtttt ccaccggcta ttttggatac ggcaagcgca
     5641 gggacggctg ccattttttg tgtgcacagg ggcgcaaagc gcccgcccgg cacgcagaag
     5701 gtgtgcgccc gcaaaatctg cgggcaaaat tcatgaaggg tggcttgcct gcctgcccat
     5761 ggagacgtaa gcgcaaaagc aggaatgcgg gaaaaagcaa gggacggttt cggcgaaaaa
     5821 gcgtctggcg gtggcggaaa agccgaacgc aagatttttt cataatagct ggctcgtaag
     5881 gtgagccgta ccaaaacttc cttgcggaaa tgtgcagcgt tatagttcat ctgcacctga
     5941 accggcagct gtgcacccgg cgcttgccgc acccaaaata gccggtggaa cgtttattta
     6001 gttttggaca ttttccagat aggtctcaaa tgcctcggca aagctggcgt tcacatcaaa
     6061 ggggacagtg tagtctacct tggaggtcac aaggcagagg tccagccggt tggaggtttc
     6121 gtctgcctgc cggttcagtt tgctcagcgc cgcatggatg accttgcggt cgtagttgat
     6181 ggtggtcacc cgcttcacat cgcagcagta ggagatctgg ttgccctcgg cgttgaagcg
     6241 gtagccggta cctccgccgg agagcagctg ctcagaactg cgcaggtcgt tcatccgttt
     6301 gaaggtgcgg gcaatgctct gccgcgcggc attcaggctg acctcgctgt ccatatccat
     6361 gtccagcgaa tcctttgcct tgcggatggc ggcaaacagg cggctttttt cctccagcag
     6421 atagagcatg aaccgggcaa cgtcggtgat ctgctctgca tattcggtct gtgccacgtc
     6481 cataacggtc tcgtcctcgg cctcgggcat caccttatgg cgcagatagg tgttggccac
     6541 cttggtcacg ttggcatcgc agtccagaat gccctgcgcc tcgtccagca gagactggag
     6601 cttgttctgg tagcggaatg cttccttcag gttcatagtc gttccctcca tcttgttttt
     6661 tctgctttca gcttaccaca gactgcccgc ccgcgcaagc cttccggtaa aatgagcaaa
     6721 acgcccgccc cggcatgacc ggggcaggcg ttttgctttt gctgtgacac ttattgggat
     6781 aagagattgg cattactcag ccggccacgc gctcggtgcg gcctgcctcc agcatatagc
     6841 gcaggaagcc ggtcacgtcg gcagggtcgg tcacggtgag gtcaaagccc ttcttggggg
     6901 cagtgtccat catctgcagc atggagcgtg cggtagcgtc ctttttcagg tcgcaggtct
     6961 tgccgttgtc cagatgcagc agcacgctgc cgtggctggc agaaagctgg ttcatgaaac
     7021 gttccttatc aaaatactcg atccgaagca taggaatacc tccttgatga aatggtttat
     7081 gttacacttg ccgtccggtc ctctttggac tggcggcggg agaatagcgg ttttgcccgg
     7141 cagtggaaac gcttgcacaa cttgcgtccc ggttgccttg gtgctatact gagcttggaa
     7201 gctctgatag gataatacca caaaacaatc gctaataata gaataaaacc gcatagtata
     7261 tgcaacaaaa ccggcattga caaaaaacat tcaaagtatt gcggaaagga attggtgaat
     7321 atggcatatc agacaagctg tgcctcttat accagcggcc gggtggggct gtccagcgct
     7381 accgccgtgg tggccgatgc cgccgggcgg gagcagaccc agcacggcag cccgctgttc
     7441 cctatcgcct gctatgccga ggatctttcc tgtttttcgg tggcgtggca ctggcacgag
     7501 gaatttgagt tcattctggc ggcgttgggg cccattcatg tggatgtgaa caagacccgg
     7561 ctgactttgc agaccgggca gggggtgttc atcaactccg gggcgctgca cgcggtagag
     7621 cctgccgagg gcagggcgct gttgcactcc ggcgtatttc agccccggct tgtcggcggc
     7681 atggacaccg tattctggca aaaactcatc cgcccgctct tgcagcccgg cacaccgccc
     7741 ttctttttgc tggacgaggc cgtgccatgg cagcggcagg tgctgctctg cctgcgggag
     7801 gcgtggaagg gcgtggcgga cgagcctttc gactacgaga accgggtgcg ttaccacctt
     7861 actgccgccc tgcggctgct cattacccaa tgcgtcagcg gcaaagtaaa ggtatcggag
     7921 caggagcaga tcgcctcgga gcggatgaag cagatgctgc gctatgtaga ggagcactac
     7981 gccgaggagc tgaccgtgga aaaactggcc gactgcgttg ccctgagcga aagcgcctgt
     8041 ctgcgcagtt tccggcagtt tctgggcatc acacccatcc agtacgtcaa gcagttccgg
     8101 gtggaaaaag ccgccgagct gctgcgctcc acccggctca agaccggcga ggtggggctg
     8161 gaatgcggct tttcggacgc gagctacttt atcaagacct tccgggagat caagcactgc
     8221 acccctcggg agtaccgtat ccgcttctgc tgagcaaaaa gtaaaaaatg ccgggcagct
     8281 gcaagctgcc cggcattgca ttataaaatt tccccctgcc agcgctccgg cgggatgacc
     8341 ggctcggtga caaaggcttc gggattcggg gcaagaacat ggcgggtgac ccggaaaagc
     8401 tcctcggcgt cgcacaaaat gcatgctgca tcgccaaatt tcgtgttcca ggctgcgccg
     8461 cagtccagat acgcctgctc cagcttgacg aaatcctccg agatatgcgg ctgctgtgcg
     8521 ttgtagtggc ggcgcatata gacggtgtgc tgcgccccgg cttcgtccac cacggtcatc
     8581 tgcatgggct tgtcggtcag gcggttcggc acgttcagta cctcctccac actatggata
     8641 aaggtgttgc gggcgtgggt gacccccagc agcagcactt tgccgtgggc tgcccgcagc
     8701 cggtcgtagc agccgccggg agtgcagggg gtgttgacgt ccagctctcc ttccagatac
     8761 gcagccgccc ccttgccgta agccgccatg ctgtgggtgg ggtgcagcga gcgcaccacc
     8821 ccggggcgct gccggaacag ttccggcaga atgcccacac agcacgggct gcggcgcaca
     8881 tcgaacaccc ggttttcctc gttgatgaac cgccatgtgt gggtgggcag caacagcaag
     8941 ccctccgcaa aaaactccat ccatgcgtcc agaaccgtgt ctgcgccgcc ctccaccggg
     9001 ccgatggact tcatggagga atggatcagg atggtctcgt tgcctgtcag ccccattgct
     9061 gcaaggtcgt gcttgaggtc agcctttgtg tatgccatgt cgtttctcct tttcgggcat
     9121 tttgtctgta cccagtttac cgccttttgt gcggcaaagc aagcacgcac gcaaaaaagg
     9181 caaacaccct gttgtatttg ccggagacga gccggtatct gcggggtgtg tgcccttgca
     9241 gcttttttag taaaatcctg tatacagcat atcatctcgc agcgttaccg cgaaacaagc
     9301 acagcgcctt gcaattatag caatttgaca gttgtttcct gttttctttg tgcatttggt
     9361 acaacagtca cttgattgca gcattttatc agcacttttc ccgcattgca aagtggtata
     9421 tcagtttttc agtttcagga acagttccgt gcgcgagtgc gcattcttgt atacaagtat
     9481 tcaaattaag ttccattcca gcattgacat tcagttgctg taacggtaca atgatactaa
     9541 gattacattt accggataaa tggagaacaa ctatggctac attacagcac actgatgagc
     9601 tctatcatat tctcgaggac gagatctgcg cgttgaagat cctgcccggg gaagcgctga
     9661 gcgaaaacca gctgtgcaag cggttcggcg tttcgcgcac tcctatccgc agcgttttgc
     9721 agcggctgga gcagaaccgc tttgtgcaga tcattccctg caagggcacc attgttaccg
     9781 ccatcgacac cggcgtggtg gaccagctca tcttccagcg tgttgcggtg gagggcatgg
     9841 tgttccggga ctttgtgcag agctgctcgc ccatggagat ccttgcggta gaacaccttt
     9901 ataatatgct gctggaagcc gctgcagggc gcagcgaccc ggagaacttt gatttcaacc
     9961 acttcctcag ctgcgacctt gccatgcacg agtactggtt ccacaagacc agcaaggagt
    10021 acctttggga gcagatgacc cgcccgcagg cagactactc ccgctttatc cgtctggaca
    10081 tcgtgggtgc acgcaacgtg tccagcgtcg tcagcgagca cgccgagatg ctgcgcatcc
    10141 tgcgtgagaa ggatctggac gccatcgagc cgctgatgcg cacccacctg tacggcggtg
    10201 tgagccgtat gggcagcaag atctactcgg acgaataccg cggctacttc aagctgccgg
    10261 agaacaaaca ataaagaagg ccgctgcaca ggttcctgtg cagcggcctt cttctggttg
    10321 cgccagcagg agtcgaacct acgatggggg agtcaaagtc ccctgcctta ccgcttggcg
    10381 atggcgcatc atgcaaaata gtatagcata ttttccgctg ttccacaaga ggtgcgccgc
    10441 atttttgcag ctttttctgt gcgctgtctg ccgcacttgc ggcggtttgg gtcggttttt
    10501 gggctttgcg gccgggaccc tgcgttttcc atatccttcc atgtttttac gaaaggcaag
    10561 ttttgcggga tgcgtttttc aaaaaacaca gtccgcaggg ggcacaagat tcatattgca
    10621 aaggtgaaat ttattttttt cctgattttt cttattattt tctcaaaaga ctgtattttt
    10681 tgttgcgatt ctggtacact ggatgtgata aaaataagtt gaagaaacta cgccgatgtc
    10741 cgggctgtcc ccgggcgggg cagtgtctcc atctttgtga aggaaagcga gggatctcat
    10801 gaaaaaattc ctgaaaacgc tggtggtcgg gctttgcctg ttcacgctgc tgtgctgcgc
    10861 actgccggct gcatttgccg ccgacaaaac ttcagggagc aaaaaggaag agaacgtgta
    10921 cgccattggt atggatgccc aaggcggcat ctgctccacc gtggtaacct acacgaacct
    10981 gtccggcaaa ctggagagca cgcccgagca gcctaccatg acgggctaca cctttgatgg
    11041 ctggtacacc gagccggtgg gcggcagcaa ggtgaccacc tccaccgtgt tcacctccga
    11101 cgccaccatc tacgcccact ggactgccaa ggccggtact tctaccgtgc cgcagcccac
    11161 cacccagcct gccgccaccc agtggcaaaa gtatgtaggc cctgcccttg tggccggtgc
    11221 cctgcttact accctgctgg tcgccaccat gttctgaaca ctgctgtaaa cacaatgaca
    11281 ccattgaaga aagggatctt accatgacta cttctaccat gaaaatgccc gccagctatt
    11341 ccaccatcga agccgaggag atgacctatc tggacggcgg cgccagcaac gcttatcagt
    11401 ccttcctgga catcggcaag gtgttcaact acattgcccg catcttctcc ggtgcaagct
    11461 ccatcatcaa caacgttaac gtcatctacc agtcctttgt atcgctgaac agcctgctgg
    11521 gcagcttcgg caagtaaaag catcacccca aagttcagat ccgggagccg cgcttttttc
    11581 gaaaagtgcg gctcccgttt ttcgtacacg ctgcaattca gtgcattact gcgcagaact
    11641 tcgcgttcca gaattgtgaa cagccttttt aagttttttg ggggtcagtg gccgtttttt
    11701 gggctttttc tatataaaaa gcaaaaaaat gcgatatttt ttgggcttta tctcttgatt
    11761 ttgtgtctga tttgttatat tgttgttaca tggaatgtgc taaaataaga tagtttataa
    11821 aaggtctctc cagctgcgca agttgcgtgg caacaagtga gttttcaggc attttcttta
    11881 agttttttcg gtattttcga aaaaaatttc gttatcttta cattcgggag tttgtacgca
    11941 aatggcagat cgtgaactgc ggcggatgca ccgcgctgaa ctgatagaga tcatctatgc
    12001 gctgaagcag agcgaggacc agctcaaggc gcagaacgcc gcgcttaccg cgcagctgca
    12061 ggaccggcag ctgcggctgg aaagcgccgg ttccatcgcg caggccgcgc tggagctgaa
    12121 caacgtgttc gccgccgcgc aggccgccgc cgatgactat ctgcactcgg tgcaggccag
    12181 tcttgcggac actaacgcca ccgccgccaa taccctttcg caggcgcgca gcgaggccaa
    12241 gcgcattctg gagcaggcac aggcagacgc cgacagcctg aaagcgcagg cgcagcagga
    12301 atgtgacgcc atgaccgccg ccgccgcgca aaaacgcacc cagaccgagg ccgactgcaa
    12361 ggccatggta gagcgtgccg agcaggaggt gcagcagcgc tggcaggcat ttgaccacaa
    12421 ggccaacgag ctgctggatc aataccgcag cactgacggc ctgccttcgg aggaaacatg
    12481 aaaaaacgcg atatccggtt tgcttccatc ccttccaccg aggaagtggc cgcagaacgt
    12541 gagcgtcttg cgtaccagag ccgctaccag cgggtgctgc gcagtacgat ctatattttg
    12601 gtggtggtgg ccgcagcagc cgtgctgctg gctacgctgt ttctgccggt gcttcaagtc
    12661 tccggcgaca gcatgtaccc tacattaaat gataaagaca ttatcctgct ggtaaaatcc
    12721 aaccacattg aaaacggcga gctgtgcggg ttttactggc agaacaagct gctgctcaag
    12781 cgcatcatcg ggcagcccgg tgatgtgatc gatatggacg tgaacggcgt agtctcggta
    12841 aacggcgtgg cgctggacga accctatgtg gacgcgctga ccgtgggcga atgcgacatc
    12901 cggttcccct atcaggtgcc ggaaaaccgc tacttcgtgc tgggcgacca ccgtgccacc
    12961 tccatcgaca gccgcagcag cgtgataggc tgcgttgaaa aaagccagat cgtgggcagg
    13021 gtttttctaa gggtatggcc cttgtccagc ttctcgttga tccattgacc ccgggaggag
    13081 gtatttcgtt atgaacgaca ttcttaaaac gtacatggag cggttccgtg agaaccggca
    13141 caccctgcgg cgctacaccg catttgtgct ggcacttgcc atgatcacca ccctgttcgt
    13201 caactggcag ctgcatggcg tgggcatctc gatgaccgcg cagtaccagt gcggcgagga
    13261 ggagcacgcc cacaccgcgg attgctacac caaggtgctc acctgcggtt acgaggaagg
    13321 cgagcttgaa aatgcggacg aggtggccgc cgctgctgcc accagccagc ccaccgttga
    13381 ggctgagccc gcgccgctgg cactggagcc gcagatcgag tttgtgcccc acgagcacac
    13441 cgaggactgc tacaccgagg tgcagactct gacctgcatg gaagaagagc acgtccacgg
    13501 tgacgactgc ttcgaccctg aggatggcag cctgatctgc gataaatttg agcataccca
    13561 cgatgaaagc tgctatacca ccgagtacga gctgacctgt ggactggaag agggcgagct
    13621 tgtggagcag gtggtggagc ccacccagag cgccgagctg gcggctatgg ctgtggccga
    13681 gcctgtggca ctggaaccga cggtggacac cgtggagccc atctaccacc accacactga
    13741 cgcctgctac gaggaagtgc ttacctgccc cctgccggag catcaccaca ccgtagcctg
    13801 cctgagcgat acctctgccg accttgagac ccccgaggag tggcaggccg ccaacgccga
    13861 tgccgtgatc accggcgagt ggaacgagga tctgctcagc gtggcaaaga ctcagttggg
    13921 ctacgagcag agcgagaaaa acttcgagat cgacccggcg gacggcgtga ccctgcgcta
    13981 ctactcccgc tacggtcagt cctatggcaa tgcctacggc gagtgggacg tgatgttcct
    14041 tgcctactgc ctgaagtacg ccgagattcc ccaaagcgcc atcccgcagg ag
//
