LOCUS       c00012_gnlPro..        16673 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|JOIDCPPJ_12.
ACCESSION   c00012_gnlPro..
VERSION     c00012_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 02:05:46
            Original ID  :: gnl|Prokka|JOIDCPPJ_12
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 36946
            Orig. end    :: 53619
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16673
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[46946:49938]"
                     /cutoff="2000"
                     /detection_rule="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /neighbourhood="10000"
                     /product="Pyruvate2acetate-formate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..12992
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="2000"
                     /detection_rule="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /neighbourhood="10000"
                     /product="Pyruvate2acetate-formate"
                     /protocluster_number="1"
     cand_cluster    1..16673
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /kind="single"
                     /product="Pyruvate2acetate-formate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16673
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Pyruvate2acetate-formate"
                     /region_number="2"
                     /rules="((PFL_acetate1 or PFL_acetate2) and Radical_SAM)"
                     /tool="gutsmash"
     CDS             complement(795..2003)
                     /locus_tag="ctg12_38"
                     /transl_table=11
                     /translation="METQQRSTEYNFQGIMYFFRREKIQCRYQFSLRDAVDITLLQRAL
                     TAALASAPYYTQRLVQEKREMWLEPNTEPCLVYPGSTMRNIPEQTNGYLFCVSCEGDTV
                     YFDWHHFLLDGHGVSPLLTSILEQYCNLRYGTTFAVPQIVCDPPYDMEAMLAEYPPVEG
                     GSDAIQRDVVQTYEGALRRTRVCLSKQSLVEKALANNAKPVSALMGLLCMAMREYLGKE
                     KIRYSYSSDTRDVAGVPNALYNCVCSFGHTVQLQAQTRLADFVADVDADIRRDLQPESK
                     RHRMADQMGWVYKVDQQKAPLRIKQRVFQMGEYISGTISDFWLSYLGNPLMPATPELAQ
                     YTTDFGVWVPPDGASVGVEAASLNGKIILCIHNKAPNPGLAETLRKTFESEGVAVLEAE
                     DLD"
     CDS             complement(2010..2252)
                     /locus_tag="ctg12_39"
                     /transl_table=11
                     /translation="MERAEIISQITAILEDVAEVSPEDVTESSVLMDDLDLSSMEILTI
                     VADLEETFGLRIPEKELRNFVTMGDLVDYLAANVG"
     CDS             complement(2280..3749)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1025:AMP-binding enzyme (Score: 211.7; E-value:
                     4.9e-65)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg12_40"
                     /sec_met_domain="AMP-binding (E-value: 4e-65, bitscore:
                     211.7, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIKVLDNVYDLVTLNMEQRFSERVALRFYDKETDEVTVVHYKDYA
                     RDIRRAVNYFQSTIPDIKGKKICLLNKNSYEYAVNTFGIILAGGVLVLLNQHKSWDELS
                     YELGLVDPAAILTDGDDYGTKEQLQAAYGSILRPMDGFRAYEPVAEMPRCIGHDDLMIL
                     MFTSGTTGRSKGVMLSERNFFSVMRAHVQIGERMMEYKHDPELVVSQYTVLPMFHLGAF
                     ICLFSWAHGGWALNISGDIRNFYKEIRRMPSQVMAVVPVIMNSLHKDVMRGRKERLGEL
                     WVPICSSAMFDPQVMLDMATNGMFVVQTYGATETCGDGIINYAQDAKHIGAVGQGNDYL
                     DYKLEPDGELCIRGDSIMLGYYKDPEATAAVIDKDGWFHTGDLARVDEDGYYYITGRKK
                     NLIILDSGENVSPEELEGMLEKCPAVQECIVKELGKKIGVVVYCEKEHQQTVRDFIAQM
                     NRTVPLYKRIGVVEFSETPLPRNATGKLVRK"
     CDS             4124..5239
                     /locus_tag="ctg12_41"
                     /transl_table=11
                     /translation="METTKPRTVNSIGMFDMLKGAGMLAIVLGHTAELYPLQLEGGLSL
                     TAFVGFIYRETLMAAFFIASGYGFRKRSISKCIHQQLKSLLKPFCYTAVFTTVLHFIIH
                     YKTFHYLPGSMTESIKVAGGFLLGLPHTATYFGQEFFSCGPMWYLLALLMGWILLDVIL
                     NIFPERYIPWAVGGAALLGWGASLVWELPFCLIQGAVITPYLYLGYLAKRQHWLDQPLS
                     RRMSCILWAAVLLIPAAALATRRTDCVSMAEWSLGPISILLDGLAGLLFIRLFLRWSQR
                     RNPLVRFFEAIGRRSLYIFCVHTVELIAIPWYLFAAKYADRPVLGISLQYILSLGSIWL
                     ICALLQRRRDLIIKLFPARRRTPQVHYAPRH"
     CDS             5306..6100
                     /locus_tag="ctg12_42"
                     /transl_table=11
                     /translation="MNHDAPMTPAAMQAHIAELEQQLKLSDEGVSQLAQRCLELEQQLL
                     ACQTELAKHSAEAENITLTLPQLFYDTGSGFSPRECLTATEDVYNELTHEVSVTFVLPE
                     DARAIRLDPGELACCITDLAISDERISFQSVNGLLLQEDSLLFLDVDPNLSLHCTTGFG
                     AGMKFAVNYHYYPLGRFLHEQPGKSLLRALNDLKLENAAAAQEAEEVLQASRAECMRLN
                     QQLLTLQGIQHEYQVSLETMRASSSWRLTAPLRRLLNLVRGH"
     CDS             6135..7742
                     /locus_tag="ctg12_43"
                     /transl_table=11
                     /translation="MYTSYSTLQRKQLSKQVYTDTQSTYLLVYAPGRHKALQAALQNQL
                     HRKFRLVTRLEDELTPDVAGVLLVSEDVECTPTALTYFAAALREGADLAVCDASFGFDG
                     STALYLSTRHLPGSSCALVSRALLDKVRAAARGKDSVTELLRLAHAMAQHSRCIPQALL
                     HFRRELCADDVFSAKGRRALILSHELTMTGAPIVLVSAVPVLRSLGFEVVVLGPSDEGS
                     LPLFLDAGAAVVTRPDCVTSSALWGLATSADFVLANTVVEAPVVNTLNGSFVPVLWWLH
                     DAFAGYPFISHSIPKALGKNVHLCAVGSHATAAMHSVRPDFAIEQLIYGLPDYAAEQFP
                     RYDISFAGGRPLFVTVGSLEHRKGPDIFCNAIRLLPSAVREKAAFLFVGKAADKGMYNA
                     VDSLVRDYPQTVFYRKRLERPEVKSLMEQCNCVVCASRDDPMPTFVTEGLIFGKPSIVS
                     EHTGTAGLVTEGVDGFLYKDDDPQQLADKLAWAVEHPEALAAMHGSCRRLYEQQFSNES
                     YVATLTRLVKELTDGEEQ"
     CDS             7920..8957
                     /locus_tag="ctg12_44"
                     /transl_table=11
                     /translation="MSQAAAQQPSRKKAVISLLVLLALTCIIVFTFKDHWAEITAALAQ
                     LSVWQVLAVLAVGLSYPLLEGCVAWVIVRSRLPQFKLCQGLDVGWCGTFGNVVTLGAGA
                     VPVQLYYLHRAGLPLGPGAGLMTLEYVFHKSTVLLYATVMLLLQHRWLAANTTGVMRYL
                     PMAYAVVAVIIVALVLLCVSPLVQNLARWLLGFLPKTEKWQQRRADWLEQLEVLGTESR
                     RLLADKPRCLKIFALQALKLFGLFCLPYLCIRFMGLSPLGFWQVQLLTSLMLFVSNALP
                     NVAGMGSIETAFLLVFGSFLERGEVMSVLMLYRIASYYVVFAASAVGFFIAQRHLAQME
                     LPKEG"
     CDS             8962..9420
                     /locus_tag="ctg12_45"
                     /transl_table=11
                     /translation="MKSFHIPRAALFFILFALAAFAVLYRPIDLKALVRASSQGTLRTE
                     EVAHFGSTNDMDYHLLSMDSEAFQQTAELLSTVSCRKKLNQNYSAYTHDTFPVQSVTVS
                     FYDDAENQKFLLTVYSDGVCILNSAFVSVKYPGGGAAQLYEQLAGMGQ"
     CDS             9575..9688
                     /locus_tag="ctg12_46"
                     /transl_table=11
                     /translation="MERSACRRSFFSGATWLELANRRCENRIPQSVSLVNP"
     CDS             10001..12253
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Pyruvate2acetate-formate: PFL_acetate2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Gly_radical"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg12_47"
                     /sec_met_domain="Gly_radical (E-value: 1.5e-40, bitscore:
                     129.7, seeds: 99, tool: rule-based-clusters)"
                     /sec_met_domain="PFL_acetate2 (E-value: 6.8e-267, bitscore:
                     878.3, seeds: 33, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIQFEQWEGFEGRIWKEEVNVRDFIQKNYTPYDGDESFLAGPTEA
                     TDKLWGALQQLQKAERAKGGVLDMETEVVSSLTSYGPGYIDENLKDLEQIVGLQTDKPL
                     KRAFMPYGGIKMAEQACTTYGYQPSAELHKIFTDYTRTHNQAVFDAYTPEMKKARHTHI
                     ITGLPDTYGRGRIVGDYRRVALYGIDALIQFKQEDLANCGDGTMTDDVIRLREEIARQI
                     SALKGMKKMAEAYGYDISQPAKDAKEACQWLYFGYLAAIKTQNGAAMSVGRISTFLDIY
                     IQRDLDRGILTESQAQELIDHMVMKFRMVKFARIPSYNQLFSGDPVWATLEVGGIGMDG
                     RSMVTKNCYRFLHTLENMGPAPEPNLTVLYSSALPEAFKKYAAKVSVNTSSVQYENDDV
                     MKPVWGDDYSICCCVSATQTGKEMQFFGARANLAKCLLYAINGGVDEKSHEQCGPNYAP
                     ITSEYLTYDEVLPKYVQMLDWLAGLYVNVLNLIQYMHDKYYYEEAEMALIDTDVRRTFA
                     TGIAGFSHVIDSLSAIKYAKVKVVRDENGLATGFETEGDFPKYGNDDDRADEIGVWLLK
                     TFLEMIKKRHTYRNSEATTSILTITSNVVYGKYTGALPDGRAAFTPFAPGATPSYGAEQ
                     NGLLASLNSVAKLPYHWALDGISNTQTINPEALGHSEGERVENLVQVLDGYFDQGAHHL
                     NVNVFGKEKLLDAMEHPEKEEYANFTIRVSGYAVKFIDLTREQQLDVLARTCHGVL"
     CDS             12240..12992
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Pyruvate2acetate-formate: Radical_SAM"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1015:4Fe-4S single cluster domain (Score: 61.6;
                     E-value: 3.2e-19)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg12_48"
                     /sec_met_domain="Radical_SAM (E-value: 4.6e-29, bitscore:
                     93.6, seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVSCKTLGYVHSLESFGSVDGPGVRFVVFLQGCALRCKYCHNPET
                     WAEGGEAWTAEALFQRVYRYRNYWGKKGGITVSGGEPLRQLDFLTEFFMLARAKGVHTA
                     LDTAGQPFRPDDPAYLAAFDRLMANTSLVILDLKEIDPERHRQLTGKDNANILAMARHI
                     SNLGIPLWVRHVLVPGLTDDEEGLRKTADFIRSLKTVQRVEVLPYHTLGLFKWQKLGIP
                     YPLPDAVPPTAEQVKRAEELLEVSRYPG"
     CDS             13497..14894
                     /locus_tag="ctg12_49"
                     /transl_table=11
                     /translation="MQIFNTLTRQKEEFVPQVPGEYRIYVCGPTVYNYIHIGNARPLIV
                     FDTLRRYLEYRGNKVIYVSNITDIDDKLIKKGQEEGTSMKEVAQRFEAEYLKDAAGLNC
                     EKPTVQPRATEHIPQILDIVKDLIDSGHAYVAKNGDVYFRVKSDPGYGKLSHLNLDDLE
                     SGNRELRSRMEDDLKEDPADFAVWKAAKPGEPAWESPYGMGRPGWHIECSAMSRTHLGK
                     TIDLHCGGQDLIFPHHENEIAQSECANGCEFARYWMHNGFINVDNQKMSKSLHNFFTVR
                     DVANLYGYEPIRYFMLTAGYRMPLNYTVDLIESCKNSLERLYTCRENLDFALSKTDFGT
                     DETLKEKAAEARTKFCTAMDDDLNTPDALAAVFDLVKEINTLSAASSKAALETAAAAFD
                     EITGVLGLLYNRKKDEVPAEVTALVEKRAAAKKAKDWATADAIRAQLTELGWAVKDTAQ
                     GPQLSKL"
     CDS             complement(15051..16268)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fe-ADH"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1035:Iron-containing alcohol dehydrogenase (Score:
                     335.1; E-value: 1.4e-102)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg12_50"
                     /sec_met_domain="Fe-ADH (E-value: 1.1e-102, bitscore:
                     335.1, seeds: 219, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MARFTLPRDLYHGKGALEALKSFTGKKAMICVGGGSMKRFGFLDR
                     AVEYLKEAGMEVELFEGIEPDPSVETVMRGAEAMLKFEPDWIIAMGGGSPIDAAKAMWI
                     KYEYPEITFEEMCKVFGIPPLRRKAHFCAISSTSGTATEVTAFSIITDYQKGIKYPIAD
                     FEITPDVAIVDPDLAETMPKKLVAHTGMDAMTHAVEAYVSTAHCDYTDPLAIFAIRMIQ
                     GDLVDSYNGDMSKRDSMHNAQCLAGMAFSNALLGIVHSMAHKTGAAFADYGAHIIHGAA
                     NAMYLPKVIAFNAKDPEAKKRYGVIADEMKLGGANDDEKVKLLIEYLRGMNDALNIPHC
                     IQHYGPDSYPTEQGFVPENVFLERLPEIAKNAIADACTGSNPRQPSQEEMEKLLKCCYY
                     DTEVDF"
ORIGIN
        1 tcggcggcgt tctggaagaa cagcagcccg gtcagcagcc agaagcgggc agagcgcaga
       61 aagctccagt cgatggcttc cttctcggca ctgcttttgc tctttccgcc gcgcagcggg
      121 gtaaagacgt acaccagcca gagcacaagg cccacggctg ccagcagaaa gaccgccagc
      181 tcggtgctta cccgggctgc cgccgcaatg aggaaggggc acagcagtgc gccgcaggcg
      241 tagcagctgt gcatcaggtt catgccccgg gtgcggtcgg cggagtgatc gctgaccaga
      301 atggtacagg tgttgataac gctgccctta gcgatgccca ccacaaaaaa ggccgctgcc
      361 agcagcgcca ctgcgccggt cagccccatg acggcgtagc ccaccgcata gccgatggtc
      421 agcagcagca cactgcgttt catgcccagc gcactgggca gcatgcccat cagcagccct
      481 gccagcaagt tgcccacgct catcagggag agcagtgtac cggtcatgcc gtaggcaaag
      541 ccgtagcgct cctgcagcag actgaccacc acacctgcgc tgatggcaca gatgccgctg
      601 aagaaaaagg tcgcaaagcc cgcattgcgc aggcgcgtgt tctgttgttc catggtgttc
      661 ctctccttgc ggaaatatcc tttctctatt taaccatttt ttcgcatctt tgcaaccgga
      721 ttttcttaca aaaagcagca aaaaaactgc cgcacaaaac gtgcagcagt tttttctttt
      781 ataataagta tttctcagtc cagatcttcc gcttccagca ccgcaacgcc ttcgctttca
      841 aaggtcttgc ggagggtttc ggccagaccc gggttgggtg ccttgttgtg gatgcacagg
      901 atgatcttac cgttcagact ggcagcctcc acgcctacgg atgcaccgtc cggcggtacc
      961 cagacgccaa aatccgtggt gtactgtgcc agctccgggg tggcaggcat gagcggattg
     1021 cccagatagc tgagccagaa gtccgaaatc gtgccgctga tgtactcgcc catctggaac
     1081 acccgctgct tgatgcgcag gggcgctttt tgctggtcca ccttgtacac ccagcccatc
     1141 tggtcggcca tacggtgacg cttggactcc ggctgcaggt cccgcctgat gtctgcatct
     1201 acatcagcca caaaatctgc aaggcgggtc tgggcttgca gctgcaccgt atgcccgaaa
     1261 ctgcacacgc agttgtacag cgcattcggc acaccggcca catcgcgggt atcagacgag
     1321 taggaatacc ggatcttctc cttgcccaga tactcccgca tggccataca cagcagaccc
     1381 atcagagcgc ttaccggctt tgcgttgttc gccagcgctt tttccacaag gctctgcttg
     1441 ctcaggcaca cccgggtgcg gcgcagcgca ccctcgtagg tctgcaccac atcccgctgg
     1501 atggcatcgc tcccgccctc cacaggcggg tactctgcca gcatggcctc catatcatag
     1561 ggcgggtcgc acacgatctg cggcaccgca aaggtcgtgc cgtagcgcag gttgcagtac
     1621 tgttccagaa tgctggtgag caggggcgat accccgtggc cgtccagcag gaagtgatgc
     1681 cagtcaaagt agacggtatc cccttcgcag ctgacgcaga acaggtagcc gttcgtctgt
     1741 tccgggatat tgcgcatggt gctgccgggg tacacaaggc agggctccgt attgggctcc
     1801 agccacatct cccgcttttc ctgtaccaga cgctgcgtat aataaggcgc acttgccaag
     1861 gccgctgtca gtgcccgctg caaaagggtg atatccaccg catcccgcag cgagaactgg
     1921 taccggcact ggatcttttc ccgacggaaa aagtacatga ttccctgaaa gttatattcc
     1981 gtcgagcgct gttgtgtttc cattggtttt taccccacgt ttgctgccag ataatccacc
     2041 agatccccca tggtgacaaa gttgcgcagc tccttttccg ggatgcgcag accaaaggtc
     2101 tcctcaagat ctgccacaat ggtcaggatc tccatagagg acagatccag atcgtccatc
     2161 aggacgctgc tttcggtcac atcctccggc gatacctctg cgacatcctc cagaatagcc
     2221 gtgatctgag aaatgatttc tgcacgttcc atcgtattat gcttcctttc tgttgcgtat
     2281 tacttgcgca ccagcttgcc cgtagcgttg cggggcagcg gcgtttcgct gaattccacc
     2341 acgccaatgc gcttgtacag cgggacagtg cggttcatct gggcaataaa gtcccgcacc
     2401 gtctgctggt gctccttttc acagtatacc acaacaccta tctttttgcc cagttctttt
     2461 acgatacatt cctgtacggc gggacatttt tctaacatgc cctccagctc ctcgggactg
     2521 acgttctcgc cgctgtccag aatgatcagg ttcttcttgc ggccggtaat gtaatagtag
     2581 ccgtcctcgt ccacccgggc aaggtcgccg gtgtggaacc agccgtcctt gtcgatgacc
     2641 gcagcggtgg cctcggggtc cttgtagtag cccagcatga tgctgtcgcc ccggatgcac
     2701 agctctccgt ccggctcgag cttgtagtcc agataatcgt tgccctgtcc cacagcgccg
     2761 atgtgctttg catcctgcgc gtagttgatg atgccatcgc cgcaggtctc ggtagcgccg
     2821 taggtctgca ccacgaacat cccgttggtg gccatatcca gcatcacctg cgggtcaaac
     2881 atcgcagagg agcagatggg cacccacagc tcgcccaagc gctccttgcg gccgcgcatc
     2941 acgtccttgt gcagggagtt catgatcacc ggcaccaccg ccatgacctg actgggcatc
     3001 cgccggatct ccttatagaa attgcggata tcgccgctga tgttcagcgc ccagcccccg
     3061 tgtgcccaag agaacaggca gatgaatgca cccagatgga acatgggcag caccgtgtac
     3121 tggctgacca caagctccgg gtcgtgctta tactccatca tgcgctcacc gatctgcaca
     3181 tgggcgcgca tcacgctgaa gaagttgcgc tcgctcagca tcacgccctt gctgcgtccg
     3241 gtggtgccgg aggtgaacat caggatcatc aggtcgtcgt ggccgatgca gcggggcatc
     3301 tctgccaccg gctcataagc gcggaagccg tccatggggc gcaggatgct gccgtaggcg
     3361 gcctgcagct gctcttttgt gccgtagtcg tcgccgtcgg tcaggatggc agcggggtcc
     3421 accagcccca gctcgtagga cagctcgtcc cagctcttgt gctggttgag cagtaccagc
     3481 acgccgcccg ccagaatgat gccgaaggtg ttcacggcat attcgtagct gtttttattc
     3541 agcagacaga tctttttgcc cttaatatcc gggatggtgc tctggaagta gttgaccgca
     3601 cggcggatat cccgcgcgta gtccttataa tggactacgg tcacctcgtc cgtttcctta
     3661 tcataaaagc ggagcgccac acgctccgaa aaacgctgtt ccatattcag ggtgaccaga
     3721 tcatacacgt tgtccaatac cttgatcatt gtattttcct cctgcgttgt tattacatcc
     3781 tgcggcagtg cgctgtactg tgctcagtat acaatatttt ccaatgcaat gcaatacttc
     3841 tgcaacattt aatttctcac tttgacaact ttcaattgca tatattggga tacgccccgg
     3901 ccaaattcta cctttcgttg caatccgccg gttttcgtgc tacaattttt agcgcaaaat
     3961 accagttccg gtatggtgca gactgcaaaa caaaattgac agtctctata aaaagcatta
     4021 tactagccat atatcatggc aatgctgtat aaaaactgat catttgcgcc gtatccggct
     4081 ttttctcgag gggtattggc ccggcgcagg gaaggaatct ttcatggaaa caaccaagcc
     4141 ccgcactgtc aactccatcg ggatgtttga tatgctcaag ggcgctggga tgctggccat
     4201 cgtgctggga cacactgcgg agctttaccc actccagctg gagggcggcc tgtcgctgac
     4261 ggcctttgtc ggctttatct accgcgaaac gctgatggcg gcctttttta ttgccagcgg
     4321 ctacggcttc cgcaagcgct ccatcagcaa gtgcatccac cagcagctca aaagcctgct
     4381 caagcccttt tgctacactg cggtgttcac cacggtgctg cacttcatca ttcattataa
     4441 aacctttcac tatctgcccg gctccatgac tgagagcatc aaggtggcgg gcggctttct
     4501 gctgggtctg ccccatactg ccacctactt cgggcaggag ttcttttcct gtgggcccat
     4561 gtggtatctg ctggcgctgt tgatgggctg gatcttactg gacgttatcc tgaatatctt
     4621 cccggagcgg tacattccct gggcggtggg cggtgccgcc ctgctgggct ggggtgccag
     4681 ccttgtatgg gagctgccct tctgcctgat ccagggcgcg gtgatcacgc cgtacctgta
     4741 ccttggctac cttgccaaac ggcagcattg gctggatcag cctttgtccc gccggatgtc
     4801 ctgcatcctg tgggcagccg tactgctgat cccggcagcc gcccttgcca cccgccgcac
     4861 cgactgtgta tccatggccg agtggtcgct gggccccatc agcatcctgc tggacggcct
     4921 tgccggtctg ctgtttatcc ggctgttttt gcgctggagc cagcgccgca acccgctggt
     4981 gcgctttttc gaggccatcg gccgccgttc tctgtacatc ttctgcgtac atacggtgga
     5041 gctgatcgcc attccgtggt atctgttcgc cgccaaatac gccgaccgcc ctgttttggg
     5101 catcagcctg caatacatcc tttcgctggg ctccatctgg ctgatctgcg ccctgctgca
     5161 gcggcggcgg gatctgatca tcaagttgtt ccccgcccgg cggcgcaccc ctcaggtaca
     5221 ttacgccccg cggcactgat ttttctgaat gttttggctg cggcggtgca gctgttatag
     5281 gataaaggaa gaggaggatc ccgttatgaa ccacgatgcc cccatgaccc ctgctgccat
     5341 gcaggcgcac attgccgagc tggagcagca gctcaagctt tcggacgagg gtgtttccca
     5401 gctggcgcag cggtgtctgg agctggagca gcagttgctg gcttgccaga ccgagcttgc
     5461 caagcacagc gccgaggctg agaatatcac ccttaccctg ccgcagctgt tctacgacac
     5521 cggcagcggc ttttcgcccc gggaatgcct gactgccacc gaggatgtct acaacgaact
     5581 gacccacgag gtctcggtca cctttgtcct gccggaggac gcacgcgcca tccgtctgga
     5641 ccccggcgag ctggcctgct gcatcaccga ccttgccatc tcggacgaac gcatcagctt
     5701 ccagtcggtc aacggccttc tgctgcagga ggacagcctg ctgtttttgg acgtagaccc
     5761 caacctttcg ctgcactgca ccaccggctt tggtgccggc atgaagtttg cggtgaacta
     5821 tcactactac ccgctgggac gttttctgca cgagcagccc ggcaagtctc tgctgcgggc
     5881 gctgaacgac ctgaagcttg agaacgccgc tgccgcgcag gaggcagagg aagtattgca
     5941 ggccagccgc gccgagtgta tgcggctgaa ccagcagctg ctgaccttgc agggcatcca
     6001 gcacgaatat caggtttcgc tggaaacgat gcgcgccagc agcagctggc ggctgaccgc
     6061 cccgctgcgc agactgctga acctagtgcg cggtcactga gcccgcccga tattctgccc
     6121 ggaggagttg gatcatgtac accagttaca gtaccctgca gcgcaagcaa ttgtccaagc
     6181 aggtctatac cgatacccag agcacctatc ttctggtcta cgcgccgggg cgtcacaagg
     6241 cgctgcaagc ggcgctgcaa aaccagctgc accgcaagtt ccgtctggtg acccggcttg
     6301 aggacgagct gacccccgat gtagccgggg tgctgctggt aagcgaggat gtggagtgca
     6361 cccccaccgc cctgacttat tttgccgctg ccctgcggga gggcgcagac cttgcggtct
     6421 gcgacgcctc ctttggcttt gacggctcca ccgccctgta cctgagcacc cggcacctgc
     6481 ccggcagcag ctgcgcactg gtgtcccgcg cattgctgga caaggtacgc gccgccgccc
     6541 ggggcaagga cagcgttacc gaactgctgc gtctggccca cgccatggcg cagcacagcc
     6601 gctgcatccc gcaggcgctg ctgcacttcc gccgggagct gtgcgccgac gatgtattct
     6661 ctgccaaggg acgccgtgcg ctgattttga gccatgagct gaccatgacc ggtgcgccca
     6721 tcgtgctggt aagtgccgtg ccggtgctgc gcagcttagg ctttgaggtg gtggtgctgg
     6781 gaccctcgga tgaaggctcg ctgccgctgt ttctggacgc cggggccgct gtggtcaccc
     6841 gcccggactg cgttacttcc agcgccctgt gggggctggc caccagcgca gactttgtgc
     6901 tggccaacac ggtggtggaa gcgccggtgg tgaacaccct gaacggctcc tttgtgccgg
     6961 tgctgtggtg gctgcacgat gcctttgcgg gctacccctt catctcccac agcatcccca
     7021 aggcgctggg caaaaacgtg cacctctgcg ccgtaggctc ccacgccacc gccgccatgc
     7081 actccgtccg gccggatttt gccatcgagc agctgatcta cggtctgccg gactatgcag
     7141 ccgagcaatt cccccgctat gacatcagct ttgccggggg gcgtcccctc tttgtgacgg
     7201 taggctcgct ggaacaccgc aagggtccgg acatcttctg caacgccatc cggctgctgc
     7261 cctctgcagt gcgggaaaaa gctgccttcc tttttgtggg caaagccgcc gacaagggga
     7321 tgtacaacgc cgtggacagc ttggtgcggg actatcccca gaccgttttt taccgcaagc
     7381 ggctggagcg cccggaggtc aaatccctga tggagcagtg caactgcgtg gtgtgcgcct
     7441 cccgggatga ccccatgccc accttcgtca ccgagggtct gatcttcggc aagccctcca
     7501 tcgtatcgga gcacaccggc accgccgggc tggtgaccga gggcgtggat ggcttcctct
     7561 acaaggacga cgacccgcag cagctggccg acaagctggc ctgggccgtc gaacacccgg
     7621 aggcgctggc cgccatgcac ggcagctgcc gccgcctgta cgagcagcag ttctccaacg
     7681 aatcctatgt cgccaccctg acaaggctgg taaaagagct gacggacggg gaagaacaat
     7741 gaaaaaacaa tgccggacag ccgcacgctg cccggcattg ctttttcacg ggagaggttt
     7801 tcccatttta tcaaatcccc caaattgccc aacaaagttc cgcttccgtt cacaaagggc
     7861 ggcgggagat gtgctatact ggttccagaa tttccggttg tgaaaggagt tttgtttcca
     7921 tgagccaagc cgccgcgcag cagccctccc gcaaaaaggc cgtgatctcc ctgctggtgc
     7981 tgctggcact tacctgcatc atcgtgttca cttttaagga tcactgggcc gagatcactg
     8041 cggcgctggc gcagctttcg gtgtggcagg tgctggcggt gctggcggtc ggcctcagct
     8101 accccctgct ggaagggtgc gtggcgtggg tcatcgtgcg cagccgtctg ccgcagttca
     8161 aactgtgtca ggggttagat gtgggctggt gcggcacctt tggcaacgtg gtcacgctgg
     8221 gtgccggtgc tgttccggtg cagctgtact acctgcaccg ggccgggctg ccgctgggcc
     8281 ccggcgcagg gctgatgacg ctggaatacg ttttccacaa gagcacggtg cttttgtacg
     8341 ccaccgtgat gctgctgttg cagcaccgct ggcttgccgc caacaccacc ggtgtcatgc
     8401 ggtatctgcc catggcatac gctgtggtag cggtgattat cgtggcgctg gtgctgctgt
     8461 gcgtctcacc gctggtgcag aacctcgccc gctggctgct gggctttttg cccaaaaccg
     8521 aaaagtggca gcagcgccgc gccgactggc tggagcagct ggaggtgctg ggcaccgaga
     8581 gccgccgcct gctggcagat aagccccgct gcctgaaaat ttttgccctg caggcgctca
     8641 agctgttcgg gctgttctgc ctgccctacc tgtgcatccg gttcatgggg ctttccccgc
     8701 tgggcttctg gcaggtgcag ctgctcacca gcctgatgct cttcgtttcc aacgccctgc
     8761 ccaacgtagc cgggatgggc tcgattgaaa ccgcctttct gctggtgttc ggcagctttc
     8821 tggaacgggg cgaggtgatg agcgtgctga tgctctaccg cattgccagc tattatgtag
     8881 tatttgccgc cagcgccgtg ggctttttca tcgcccagcg gcatctggcg caaatggaac
     8941 tgccaaagga ggggtgagca gatgaaaagc ttccacattc cccgcgccgc tttatttttt
     9001 atcctgtttg cactggcagc ttttgcggtg ctgtaccgtc ccatcgacct gaaagcactg
     9061 gtacgcgcca gctcgcaggg cacgctccgc accgaggaag tggcgcattt tggcagcaca
     9121 aacgacatgg actatcacct cctctccatg gacagcgaag cgttccaaca aacggcagaa
     9181 ttgctttcca ccgtctcctg ccgcaaaaag ctgaaccaga actattctgc ctacacccac
     9241 gatacctttc cggtgcagtc ggtcaccgtc agcttttatg acgatgccga gaaccagaag
     9301 tttctgctga cggtgtattc tgacggtgtg tgcatcctga acagcgcctt tgtcagcgta
     9361 aaataccccg gcggcggcgc agcgcagctg tatgaacagc tggcggggat ggggcagtaa
     9421 aaacaaaaat cggggcactc aggtggtcaa gctgagtgtc ccgtttttgt tttctttgcg
     9481 tcggctgtgg taccaaacac agccggtgcc gcgccggaag cagcagagca aaccgtgctg
     9541 ccgcttcccg tagaaaagag aaaggaatgg aggaatggag cggagcgctt gcagacgctc
     9601 ctttttttct ggtgcaacgt ggttagaatt agctaaccgc cgctgcgaga acaggatacc
     9661 acagtcagtt agtcttgtca acccttaatt tgcaaatttt ttcgcaaagt tgccgtgccg
     9721 ccggggtttc tgccgttttt ctacattctg cccaaagaac agcctttccg ctggaagaaa
     9781 acccacttgt tttctattgc tttttaaaac ggttcttgct attataataa cgcaagattt
     9841 tgtgggcagg tttttatttt tgtctacacc ttgtagtaag ggctgccgct gtcggcagcg
     9901 caagaccgtt tcgcccccag aaaaccgccc agacagagcg gtttttcaaa ggctcattag
     9961 ttagaaaacg ctaaccgcgt aatggagcaa ggaggttcca atgatccagt ttgaacagtg
    10021 ggaaggcttt gaaggccgca tctggaagga agaggtcaat gtgcgtgact tcatccagaa
    10081 gaactacacc ccctatgacg gcgacgaaag ctttctggca ggccccaccg aggctaccga
    10141 taagctttgg ggtgctttgc agcagctgca gaaggccgag cgcgccaagg gcggcgtgct
    10201 ggatatggag accgaggtgg tcagcagcct gacttcctac ggccccggct atattgacga
    10261 aaacctgaag gatctggagc agatcgttgg cttacagacc gacaagcccc tcaagcgcgc
    10321 ctttatgccc tacggcggca tcaagatggc agagcaggcc tgcaccacct acggctacca
    10381 gccctctgcc gagctgcaca agatctttac cgactacacc cgcacccaca atcaggccgt
    10441 gttcgatgcc tacaccccgg agatgaagaa ggcacgccac acccacatca tcaccggtct
    10501 gccagacacc tatggacgcg gccgcatcgt gggcgactac cgccgcgttg ccctgtacgg
    10561 cattgacgcc ctgatccagt tcaagcagga ggatcttgcc aactgcggcg acggcaccat
    10621 gaccgatgac gtcatccgcc tgcgcgagga gatcgcccgc cagatcagcg ccctgaaggg
    10681 catgaagaag atggccgagg cttacggcta cgacatctcc cagcccgcca aggacgccaa
    10741 ggaggcctgc cagtggctgt acttcggcta tctggccgcc atcaagaccc agaacggcgc
    10801 cgccatgagc gtgggccgca tctccacctt ccttgacatt tatatccagc gcgatctgga
    10861 caggggcatc ctgaccgaaa gtcaggcaca ggagctcatc gaccacatgg tcatgaagtt
    10921 ccgcatggtc aagtttgccc gcatccccag ctacaaccag ctgttctccg gcgaccccgt
    10981 gtgggcgacc ctggaggtgg gcggcatcgg catggacggc cgcagcatgg tcaccaagaa
    11041 ctgctaccgc ttcctgcaca cgctggaaaa catgggcccc gcaccggagc ccaacctgac
    11101 cgtgctgtac tcctctgccc tgcccgaggc ctttaagaag tacgccgcca aggtgtccgt
    11161 caacaccagc agcgtccagt acgagaacga cgatgtgatg aagcccgtct ggggcgacga
    11221 ttactccatc tgctgctgcg tgtctgccac ccagaccggc aaggagatgc agttcttcgg
    11281 cgcacgcgcc aaccttgcca agtgcctgct gtatgccatc aacggcggtg tggacgagaa
    11341 gagccacgag cagtgcggcc ccaactatgc ccccatcacc agcgagtacc tgacctatga
    11401 cgaggtgctg cccaagtatg tgcagatgct ggactggctg gcagggctgt acgtcaacgt
    11461 gctgaacctc atccagtata tgcacgacaa gtactactac gaggaagccg agatggcact
    11521 catcgacacc gatgtgcgcc gcacctttgc caccggcatt gcaggcttct cccacgtgat
    11581 cgactccctg agcgccatca agtacgccaa ggtgaaggtg gtgcgcgatg aaaacggcct
    11641 tgccaccggc tttgagaccg agggcgattt ccccaagtac ggcaacgatg acgaccgcgc
    11701 cgacgagatc ggcgtgtggc tgctcaagac cttccttgag atgatcaaga agcgccacac
    11761 ctaccgcaac tccgaggcta ccacctccat cctgaccatc acctccaacg tggtgtacgg
    11821 caagtacacc ggcgctctgc cggatggccg cgccgccttc accccgttcg cacccggcgc
    11881 tacccccagc tacggtgccg agcagaacgg tctgctggcc tcgctgaact ccgtggcaaa
    11941 gctgccctac cactgggcac tggacggcat ctccaacacc cagaccatca accccgaggc
    12001 actgggtcac agcgagggcg agcgcgtgga gaatctggtg caggtactgg acggctactt
    12061 cgatcagggc gcacaccacc tgaacgtgaa tgtctttggc aaggagaagc tgctggacgc
    12121 catggagcac cccgagaagg aagagtacgc caacttcacc atccgcgttt ccggctacgc
    12181 cgtcaagttc atcgacctga cccgcgagca gcagctggac gtgctggcac gcacctgcca
    12241 tggtgtcctg taagaccctt gggtacgtcc actcgctgga atccttcggc tcggtggacg
    12301 gccccggcgt gcgctttgtg gtgtttttgc aggggtgtgc cctgcggtgc aagtactgcc
    12361 acaaccccga aacatgggca gagggcggcg aggcgtggac ggcagaagcg ctgttccagc
    12421 gggtataccg ctaccgcaac tactggggca aaaagggcgg catcacggtc agcggcggcg
    12481 agccgctgcg gcagctggat ttcctgactg agttcttcat gctggcgcgt gccaagggcg
    12541 tgcacacggc gctggacact gccgggcagc ccttccgccc ggatgacccg gcctatctgg
    12601 ccgcatttga ccgcctgatg gctaacacca gtctggtgat ccttgacctc aaggaaatcg
    12661 acccggagcg ccaccggcag ctcaccggca aggacaacgc caacatcctt gccatggcgc
    12721 ggcacatctc caacctcggc atcccgctgt gggtgcggca cgtcctcgtg cccgggctga
    12781 ccgacgacga ggaagggctg cgcaaaacgg cagacttcat ccgcagcctg aaaacggtgc
    12841 agcgggtgga ggtgctgccc taccacacct tggggctgtt caaatggcag aagctgggta
    12901 tcccctatcc cctgccggac gctgtaccgc ccacggcaga gcaggtaaag cgggcagaag
    12961 aactgctgga agtgagccgg tatcccgggt aaagcaccac cgttttgatt gcgctccgct
    13021 tcgctctgcg cccttcccgt gaaaatggga tatcggaacg cccgcaggcg ttccgatatc
    13081 ccgaaattta aaataattct tccgctgagg atgcccaaag caacgcggag ggcattctga
    13141 atcgttcttt gttcctcctt gacttccctg caccgcaccg ctataataaa ggggtaaaag
    13201 gataaatgcg tttatccggg cagagtagcg ccgcacaccg tctgcgcaga gagaacaggc
    13261 cactggctgg aagcctgttt gcagaccgct gcgcaaagtg cgcccggaca gcacgcggcg
    13321 ggaaccccgt ggggaagtat cgccgtgcgg tgcgccgccg ttaccggctt tgagcgacaa
    13381 acagaagtgg aaccgcgatt ttgattttaa aaccgccttc ggagctgtgc cttgtgcacc
    13441 gctccggggg cgttttgttt tgcggcttct gtttggaaca aaaaggagaa ttgaccatgc
    13501 agatcttcaa caccctgacc cgacagaagg aagaatttgt gccgcaggtg cccggcgagt
    13561 accgcatcta cgtctgcggc cctaccgtgt acaactatat ccacatcggc aacgcacgtc
    13621 cgctgatcgt gttcgacact ctgcgccgct atctggaata ccggggcaac aaggtgatct
    13681 acgtttccaa catcaccgat atcgacgata agctcatcaa gaagggacag gaagagggca
    13741 cctccatgaa ggaggtggcg cagcgctttg aggccgagta cctgaaggat gccgccggtc
    13801 tgaactgcga aaagcccacc gtgcagcccc gcgctaccga gcatatcccc cagattttgg
    13861 atatcgtcaa ggatctgatc gactccggcc acgcctatgt tgccaagaac ggcgacgtgt
    13921 acttccgggt gaagagcgac cccggctacg gcaagctgag ccacctgaat ctggacgatc
    13981 tggagagcgg caaccgcgaa ctgcgcagcc gcatggagga cgatctgaag gaagatcccg
    14041 ccgactttgc cgtctggaag gctgcaaagc ccggtgagcc cgcatgggaa agcccctacg
    14101 gcatgggccg cccgggctgg cacatcgagt gcagcgccat gagccgcacc catctgggca
    14161 agaccatcga cctgcactgc ggcggtcagg acctgatctt cccccaccac gaaaacgaga
    14221 ttgcccagag cgagtgcgcc aatggctgtg agtttgcccg ctactggatg cacaacggtt
    14281 tcatcaacgt ggataaccag aaaatgtcca agagcctgca caacttcttt accgtgcggg
    14341 atgtggcaaa cctctacggc tacgagccca tccgctactt catgctgacc gccggctacc
    14401 gcatgcccct gaactacacc gtagacctca tcgagagctg caagaacagt ctggagcgcc
    14461 tgtacacctg ccgcgagaat ctggactttg ccctgagcaa gaccgacttc ggcaccgatg
    14521 agactttgaa ggaaaaggcc gccgaggcac gcaccaagtt ctgcaccgcc atggacgacg
    14581 acctgaacac cccggatgca ctggctgctg tgtttgatct ggtgaaggag atcaacaccc
    14641 tgtctgctgc ttccagcaag gctgcactgg agaccgctgc cgccgccttt gacgagatca
    14701 ccggcgtgct gggtctgctg tacaaccgca agaaggacga ggtgcccgcc gaggtgaccg
    14761 cgctggtgga gaagcgcgct gccgccaaga aagccaagga ctgggccacc gctgatgcca
    14821 tccgcgcaca gctgaccgaa ctgggctggg ctgttaagga caccgcacag ggtccccagc
    14881 tgagcaagct gtaacgcctt agtagtataa aagcggaaac gccgtaggcg tttccgaacc
    14941 ccttttttca cgggagaatg caggcgaaaa aacggcaaaa gccccgcagg gcggtatgct
    15001 ctgcggggct tttgtccata gggaaggagg cgtaataaag aaaggacgaa tcagaaatcc
    15061 acctcagtat cgtagtagca gcacttgagc agcttctcca tctcctcctg actgggctgg
    15121 cgggggttgg agccggtgca ggcgtcggcg atggcgttct tggcgatctc gggcagccgc
    15181 tccaggaaca cattctccgg cacaaagccc tgctcggtgg ggtaggagtc cgggccgtag
    15241 tgctggatgc agtgggggat gttcagcgcg tcgttcatgc cgcgcaggta ctcgatgagc
    15301 agcttgacct tctcgtcatc gtttgcgccg cccagcttca tctcgtctgc gatgacaccg
    15361 tagcgcttct tggcctccgg gtccttggcg ttgaaggcga tgaccttggg caggtacatg
    15421 gcgttagccg caccgtggat gatgtgtgcg ccgtagtctg caaaggcagc gccggtcttg
    15481 tgtgccatgg agtgcacgat gcccagcaga gcgttggaga aggccatacc ggcaaggcac
    15541 tgggcgttgt gcatggagtc gcgcttggac atatcgccat tgtagctgtc caccagatcg
    15601 ccctggatca tgcggatggc aaaaatggcc agcggatcgg tgtagtcgca gtgtgcggtg
    15661 gaaacgtaag cctccacggc atgggtcatg gcgtccatac cggtgtgggc aaccagcttt
    15721 ttgggcatgg tctcagccag atcggggtcc acgatggcca cgtccggggt gatctcaaag
    15781 tctgcgatgg ggtacttgat gcccttctgg tagtcggtga taatggagaa agcggtcacc
    15841 tcggtggcag tgccggaggt ggaggaaatg gcgcagaagt gtgccttgcg gcgcagcggc
    15901 gggatgccga acaccttgca catctcctca aaggtgatct cggggtactc gtacttgatc
    15961 cacatggcct tggctgcatc gatgggagag ccgccgccca tggcaatgat ccagtcgggc
    16021 tcaaacttca gcatggcctc ggcaccgcgc atgacggtct ccacggaagg atcgggttcg
    16081 atgccctcga acagctccac ttccatgccg gcttccttca ggtactccac agcacggtcc
    16141 aagaagccga agcgcttcat ggagccgccg ccgacgcaga tcattgcctt tttgccggta
    16201 aaggatttca gcgcttccag agcgcccttg ccatggtaca gatcacgggg cagagtaaaa
    16261 cgagccataa tacaaaacct ccaaaaatag tacggcacac gcagcgctgt gccatatttt
    16321 tatttattat gttaattata taacaatttg ggggtggctt caattgacgt accgggagaa
    16381 aaagtcgttc tattttggcc ggtttccaca agcagtagga tgcaacaagc cccctgccct
    16441 gaaaaaagcg caaaaaaaca ccccgaagtc ctaggacttc gaggtgcttg cctttggagc
    16501 tgctatccag attcgaactg gagacctcat ccttaccaag gatgcgctct accaactgag
    16561 ctatagcagc aaatggcgac ccggatcggg ctcgaaccga cgacccccag cgtgacaggc
    16621 tggtgctcta accaactgag ctaccgggcc atgatcgctc aagttcgtgc ggc
//
