LOCUS       c00075_gnlPro..        13796 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|LILLEPIP_75.
ACCESSION   c00075_gnlPro..
VERSION     c00075_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 00:48:06
            Original ID  :: gnl|Prokka|LILLEPIP_75
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13796
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13796
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1632:13347]"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [PFOR_II, POR, POR_N]) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (Gly_radical_scatole or Gly_radical or
                     Gly_430_pcre or Gly_8-9_TMA))"
                     /neighbourhood="10000"
                     /product="OD_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1633..13347
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [PFOR_II, POR, POR_N]) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (Gly_radical_scatole or Gly_radical or
                     Gly_430_pcre or Gly_8-9_TMA))"
                     /neighbourhood="10000"
                     /product="OD_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..13796
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(1, [PFOR_II, POR, POR_N]) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (Gly_radical_scatole or Gly_radical or
                     Gly_430_pcre or Gly_8-9_TMA))"
                     /kind="single"
                     /product="OD_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13796
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="OD_AA_metabolism"
                     /region_number="1"
                     /rules="(minimum(1, [PFOR_II, POR, POR_N]) and minimum(2,
                     [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG,
                     Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (Gly_radical_scatole or Gly_radical or
                     Gly_430_pcre or Gly_8-9_TMA))"
                     /tool="gutsmash"
     CDS             complement(136..1620)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_20"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:Dihydroprymidine dehydrogenase domain II, 4Fe-4S
                     cluster (Score: 69.9; E-value: 4.8e-22)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg75_1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 1.3e-26, bitscore:
                     82.1, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_20 (E-value: 4.6e-23, bitscore: 69.9,
                     seeds: 204, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGKPTGFLEYERKESVGEAPLKRIKHFNEFHTPLSKKEQERQGAR
                     CMNCGVPFCQSGILIKGMVTGCPLNNLIPEWNDATYTGNWDEAYNRLRKTNPFPEFTGR
                     VCPHPCEVGCTCNLGGDPVNIKEKELSIIERAYESGLIKPEPPEVRTGKTVAIVGSGPS
                     GLCVAEYLNRRGHSVTVYERSDRVGGLLMYGIPNMKLEKTYIERKVKLMEKEGVVFKTG
                     VNVGVDVKAQDLKKQYDAVVLCCGASNPRDIKAPGRKSKGIYFAVDYLKAATKSLLDSN
                     FADKKYIDAKDKNVMVIGGGDTGNDCVGTSIRLGCKSLIQLEMMPKLPDERQPNNPWPE
                     WPRVCKTDYGQEEAIAVFGKDPRVYQTTVKEFIANEKGEVCKAKLVKLESKFDKKAGRN
                     IMAEVAGSEYEVPVDLVLIAAGFLGSQSYVTKAFGLDLTERTNVKTVEGHFKTNVDKVF
                     TAGDMHRGQSLVVWAIREGRDCAREVDKALMGYSNL"
     CDS             complement(1633..6168)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     OD_AA_metabolism: Glu_syn_central"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     OD_AA_metabolism: Glu_synthase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GATase_2"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg75_2"
                     /sec_met_domain="GATase_2 (E-value: 5.1e-173, bitscore:
                     564.2, seeds: 30, tool: rule-based-clusters)"
                     /sec_met_domain="Glu_syn_central (E-value: 1.2e-112,
                     bitscore: 364.6, seeds: 570, tool: rule-based-clusters)"
                     /sec_met_domain="Glu_synthase (E-value: 7.8e-154, bitscore:
                     500.8, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYQDNMRQGLYDPSLEHDNCGIGAVVNIKGLKSHETVSNALKIVE
                     NLEHRAGKDAEGKTGDGVGILVQISHKFFEKTCSTLGFSIGKERDYGIGMFFMPQDELQ
                     RNRAKKMFEIIVEKEGLNFLGWREVPVQPGILGKKAADCMPCIMQGFVKRPFDVPRGLD
                     FDRRLYIVRRVFEQSNDSAYVVSLSSRTIVYKGMFLVGQLRLFYNDLQDKDYESAIALV
                     HSRFSTNTVPSWEKAHPYRYIVHNGEINTIRGNADKMLAREENMESDYLKDEMIKLTPV
                     VDPNGSDSARLDNTLEFLLMSGMPLPLAMMITIPEPWENNEGMSREKRDFYQYYATMME
                     PWDGPASILFTDGDIMGAVLDRNGLRPSRYYITDDDQLILSSEVGVLDFDTTHIVKKER
                     LHPGKMLLVDTVKGELIDDEILKDSYVKNQPYGEWLSDNLVFLKDLKIPNVAVEEYSYE
                     ESNRLMKAFGYSYEEVKDSVLPMALNGSEAIGAMGVDTPLAVLSKRHHPLFDYFKQLFA
                     QVTNPPIDAIREEIVTSTSIYVGGEGNVLEEKAENCHVLKIHNPILTNTDLLKIRYAKV
                     KNINVKDVPITYYKGTPLDKAINHLYVAVDQAHKNGANVVILTDRGVDENHVAIPSLLA
                     VSAVHHHLIETKKSTSVSIILESGEPREVHHFATLLGYGACAINPYLAQFSIKKLIQDG
                     LLKKDYYAAVNDYNNAVLHGIVKIASKMGISTLQSYQGSQIFEAVGISKKVIDEYFTNT
                     VSRVEGITIEDIAEDVDYHHSKAFDMLGLKNDLSLDSEGDHKYRSGKEEHLYNPLTIHT
                     LQTAAWTNNYELFKQYTSMINKETSPVSLRGLMDFNYPSKGVPIEEVESVDSIVKRFKT
                     GAMSYGSISKEAHETLAIAMNMIHGKSNTGEGGEDLERLTVGPDGLNKCSAIKQVASGR
                     FGVTSRYLVSAQEIQIKMAQGAKPGEGGHLPAGKVYPWIAKTRHSTPGVGLISPPPHHD
                     IYSIEDLAQLIYDLKNANRNARISVKLVSEAGVGTVAAGVAKAGAQVILISGHDGGTGA
                     APRNSSIHNAGLPWELGLAETHQTLIKNDLRNKVIIETDGKLMSGRDVAMAAALGAEEF
                     GFATGPLITMGCVMMRVCNLDTCPVGIATQNPELRKRFKGKPEYVVNYMKFVAQEMREY
                     MAKLGVRTVDELVGRTDLLKELPEAKEYHLDLSAILNNPYVDKKHPICYNKKNEYNFEL
                     EKTLDEKVLLTKLKTALDKKQKRSISIDVGNTDRSFGTIFGSEITKKYYNTLEDDTFTV
                     QCTGAGGQSFGAFIPNGLTLELVGDSNDYFGKGLSGGKLIVYPPKGIRFKAEENIIVGN
                     VALYGATSGQAYINGVAGERFCVRNSGATAVVEGVGDHGCEYMTGGKVLIIGKTGKNFA
                     AGMSGGVAYVLDEDNDLYLSLNKEMVSSEPVVSKYDVMEIKDMITAHVAYTNSEKGKEI
                     LNDFSKYLPKFKKIIPHDYKKMLKKISEMEGKGLSAEQAQIEAFYEIKRG"
     CDS             6980..7069
                     /locus_tag="ctg75_3"
                     /transl_table=11
                     /translation="MLKFDTERRGHFAKKYAFIIIEKRKEKSQ"
     CDS             7066..7734
                     /locus_tag="ctg75_4"
                     /transl_table=11
                     /translation="MIINKFYEKLYKELINKLESDYILIPNTPENRKAINNTLTTVPCT
                     VKSLEKDSKIFKALSNKKAKAKQLSIVPKISKTLSLIIIATLICMPFNTINTLPTPTYH
                     PTVQVSILDISDGSSHQKGKNKLSEIQEQYTNKNQEQRNPKNYKKKVATNTYNTYKKQN
                     KFHLTLSTKKATQLLSTFKKFFLKTKNTYDNLSDAYDVISTLFVLISTVKESIRSKKLK
                     "
     CDS             complement(7838..9592)
                     /locus_tag="ctg75_5"
                     /transl_table=11
                     /translation="MLYKEDFGEGKNIEFKREIPKRHEKLLKDVIAFSNSTGGKIFIGI
                     EDKTNEVIGIGEKNPFRLADDISNMIFDSCTPIIDPEITIQTLEGRTVVVVEVFPGRMR
                     PYYLKSFGKEQGSYIRINDTSRPADDRKLKELELEGQKISYDTLPEIDMEYSEREAKIL
                     CNAMEKVAYDVQTTCVTRAIQETSLDPKQNTEKTEIINKMTIEKLEDLGLLCRIGKDLQ
                     PTHAFRLMTKNKIRYAKIQCALFKGTERDIFIDKREFDGPLYVQLENAYQFVLKHINLG
                     AKIEGLHRKEAYELPVRTIRELITNAVVHRSYLDESCIQVCVYDDRIEVTSPGMLYGGL
                     DIQSAKSGKSKCRNTAIAEAFRYMGLIEAWGTGIPRMIKECREYGLREPVFEELGDGIR
                     VTIFRENEELEMRKRAENIQNAENKYQYMNNINSENLASVVKEQTVEYREQNHCFNTEK
                     SLFNALDSQGNEKKYCLNDEKTLFETTSQDKTHCFETSVLTAENKYMLYKKLKELQVNK
                     SIGSVTALNIKEIIESFSGEEVFGRKEIKQKLGYKDSKAGFLIQTMREFELIKDVKGRG
                     KGKYCFDI"
     CDS             complement(9790..13347)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     OD_AA_metabolism: PFOR_II"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     OD_AA_metabolism: POR"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     OD_AA_metabolism: POR_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_7"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) EKR"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg75_6"
                     /sec_met_domain="PFOR_II (E-value: 1.5e-17, bitscore: 52.6,
                     seeds: 27, tool: rule-based-clusters)"
                     /sec_met_domain="POR_N (E-value: 7.4e-78, bitscore: 250.1,
                     seeds: 31, tool: rule-based-clusters)"
                     /sec_met_domain="POR (E-value: 7.2e-36, bitscore: 112.6,
                     seeds: 86, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 5.3e-13, bitscore:
                     37.8, seeds: 323, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_7 (E-value: 2.6e-11, bitscore: 32.8,
                     seeds: 208, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 0.00012, bitscore: 11.4,
                     seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="EKR (E-value: 9.5e-20, bitscore: 59.0,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPRAKQSMDGNTAAAHVAYAYTDVAAIYPITPSSPMADSVDQWAA
                     AGQENIFGNQVVVSEMQSEAGAAGTVHGSLAAGAITTTFTASQGLLLMIPNMYKIAAEQ
                     LPCVFDVSARTVATQSLNIFGDHSDVYACRQTGFAMLAETNPQEVMDLSPVAHLAAIEG
                     KVPFINFFDGFRTSHEIQKIEKWDYADLKEMCNMDAVKAFREHALNPEHPAMRGSHENG
                     DVFFQHREACNSVYEALPAVVKKYMGKINEKLGTNYDLFNYYGAEDADRVIIAMGSICD
                     VAEEVIDYLTAKGEKVGLIKVRLYRPWVSSALLDVIPKTAKKIAVLDRTKEPGALGDPL
                     YLDVATTLREAGLNDIVLTAGRYGLGSKDTPPSSVFAIYKELEKDAPKSRFTIGIVDDV
                     TNLSLPEVKPAPITSAPGTVECKFWGLGGDGTVGANKNSTKIIGDHTDKYIQAYFQYDS
                     KKTGGITISHLRFGDNPIRSPYYINQADFVACHNPSYVVKGYKMVQDVKPGGIFMINCQ
                     WSDEELDHHMPAAAKKYIADNNIQLYTINAIDKAIEIGMGKRTNTILQSAFFKLANIMP
                     IDEAVEFMKAAAKKSYSKKGDAVVEMNYKAIDAGVDAVHKVEIPASWSNPAADAPAKEL
                     TGRPETVKMVKEMMEPIGIMDGDSLPVSTFVDNADGQFELGASAYEKRGTAVSVPEWNP
                     EACIQCNQCAFVCSHATIRPFLVSEDEIKAAPDNMKVADTKPKASEYKFTMSVSPLDCM
                     GCGECITVCPAAAKGALKMVPQESQAAEQPVFDYLVATVGRKPGAPADTTVKGSQFNQP
                     LLEFSGSCAGCAETSYARLITQLFGEHMYISNATGCSSIWGGPAATAPYTVNKDSKQGP
                     AWANSLFEDNAEHGFGMYLGQKTLRDQAIAKLEKMAASDKASDEFKAAFAKFMETKDNT
                     KENTPDAQALIAEVEKAAAAGCPDAAEVLEKKQYLAKKSVWIFGGDGWAYDIGFGGLDH
                     VLASGENVNVMVFDTEMYSNTGGQASKASNIGEVCQFAAAGKEISKKSLAEIAMSYGYV
                     YVAQIALGANPNQAVKCLAEAEAYNGPSLIIGYAPCELHGIAKGGMNHCQDEMKKAVKA
                     GYWNLFSFDPAKKAEGKNPFTLTSKEGDGSYQEFLNNESRYTRLIKPFPERAERLFNES
                     EKVAKARYEHLQRLVELYK"
ORIGIN
        1 ccctatattt gtggcctcgg agcaaggttt gaatacgagc atatgaagcg agtattcaaa
       61 ccgcagcgac taaagtcaca aatataggtt tttttattta ctgcgagcgt ctctttgcct
      121 gcggcaaacc aaaagttaca gatttgaata tcccatcagg gctttatcaa cttctcttgc
      181 acagtcccga ccttcgcgaa ttgcccatac aacaagtgac tgtcctcgat gcatatcacc
      241 tgcagtaaag actttatcta catttgtctt gaaatgtcct tctactgtct ttacattcgt
      301 gcgttctgta agatctaagc caaaagcttt tgtaacatat gactggcttc ctaagaatcc
      361 tgctgcgatt aataccaaat caacaggtac ttcatactcg ctgccagcga cttctgccat
      421 gatatttctt ccggcttttt tgtcgaattt actttcaagt tttacgagtt ttgccttgca
      481 gacttcacct ttttcattgg caatgaattc ttttacggtt gtctgatata ctcgtgggtc
      541 tttgccaaat acagcgatag cttcttcctg accgtagtct gtcttgcaga ctctaggcca
      601 ttctggccat gggttatttg gctgacgttc atctggaagt tttggcatca tttctaactg
      661 aatgaggctc ttacatccta aacggatgga tgttccaaca cagtcatttc ctgtgtcacc
      721 gccaccgata accatgacat ttttatcttt ggcatcaatg tattttttat ctgcgaagtt
      781 agaatctaaa aggctctttg ttgctgcctt taagtaatct actgcaaaat aaattccttt
      841 gctctttctg cctggtgctt tgatgtctct tggattagag gctccacagc aaagcacaac
      901 agcatcatac tgtttcttta agtcctgtgc ttttacgtct acaccaacgt ttacgcctgt
      961 cttgaataca acgccttctt tttccatgag ctttactttt ctctcaatat atgttttttc
     1021 aagcttcatg ttaggaattc cgtacatgag cagtccacca acacggtcgg aacgctcgta
     1081 aacagttaca gaatggccac ggcggtttaa gtattctgcc acgcagagtc cggatggacc
     1141 ggaacctacg atagcaactg tctttcctgt gcggacttct ggtggttccg gtttgatcag
     1201 gccactttca taagctcgct ctataatact taactctttt tctttgatgt taaccggatc
     1261 cccgcctaag ttacaggtac atccgacttc acaaggatgt ggacatacac gacctgtaaa
     1321 ttctggaaat ggatttgtct ttctaagacg gttataagct tcatcccagt tacctgtgta
     1381 agttgcatca ttccattcag gaatcagatt attaagcggg catccggtaa ccattccttt
     1441 aatcaaaata ccggactggc aaaatggaac tccacagttc atacatcttg ctccctgtct
     1501 ctcctgttct tttttggaca ggggagtgtg aaattcgtta aaatgtttga ttctctttaa
     1561 cggcgcttct cccacgcttt cttttcgttc atattctaaa aatccagttg gttttcccat
     1621 agcgctctcc tcctatcctc ttttaatttc gtaaaatgct tcaatctgtg cctgctctgc
     1681 gctaagacct tttccttcca tttcggaaat cttcttgagc attttcttgt aatcgtgtgg
     1741 aatgattttc ttaaacttcg gtaaatattt gctaaaatca tttaagattt ctttaccttt
     1801 ttcagagttt gtatatgcca catgggcggt aatcatatcc ttaatttcca taacatcata
     1861 tttagaaaca actggttcgg aagaaaccat ttccttgttg aggcttaagt ataagtcgtt
     1921 atcctcatca agaacgtagg caacaccgcc gctcattccg gctgcgaagt tctttccagt
     1981 cttaccgata attaagactt taccaccagt catgtactcg catccgtgat cgccgacacc
     2041 ttctacaacg gctgttgcac cggagttacg aacacagaaa cgttcaccag ccacaccatt
     2101 aatataagcc tgaccgcttg ttgcaccgta aagtgctacg ttaccaacga taatattttc
     2161 ctcggctttg aagcggattc cttttggagg gtaaacgatt aatttaccac cggataatcc
     2221 ttttccgaag taatcattac tgtcaccgac aagctctaat gtaagaccat ttggaataaa
     2281 tgctccaaag ctctgtccgc cggctcctgt acactgtaca gtaaatgtat catcttccag
     2341 agtgttgtaa tatttctttg taatttcaga accaaagatt gtaccaaagg aacggtctgt
     2401 atttccaaca tcgatagaaa tgcttctctt ctgcttttta tcaagcgctg tcttcaactt
     2461 agtaagaaga actttttcat ctaatgtctt ttctaattca aagttgtatt cattcttctt
     2521 gttgtagcag attggatgct tcttatctac atatggatta tttaaaatag cagataaatc
     2581 taagtggtac tcttttgctt ctggaagttc tttcagaagg tctgtacgtc ctaccagttc
     2641 atctacagtg cggacaccaa gttttgccat gtattcacgc atttcctgtg caacgaactt
     2701 catgtagttt acaacgtatt ccggtttacc tttgaaacgt tttctaagtt ccggattctg
     2761 tgttgcgata cctactggac aagtatctaa gttacaaact ctcatcataa cgcagcccat
     2821 tgtgatcagc ggaccagtag caaatccaaa ttcttctgct ccaagtgctg ctgccattgc
     2881 tacgtcgcgg ccgctcataa gcttaccgtc cgtctcgatg ataactttat tacgaaggtc
     2941 atttttaatt aatgtctggt gtgtctcagc aagtccaagc tcccacggaa gtccggcatt
     3001 atggatagaa gaattacgag gtgctgcacc tgtaccaccg tcatgtccgg aaataaggat
     3061 tacttgtgcg ccagcttttg ctacaccggc tgcgaccgtt ccgacacctg cttcagatac
     3121 cagttttaca gaaatgcggg catttctgtt tgcatttttc aaatcataaa ttaactgtgc
     3181 caaatcttca atactgtaaa tatcgtgatg aggtggtggt gagattagtc ctacaccagg
     3241 tgttgaatgt cttgtctttg caatccaagg atatactttt cctgctggta aatgtccacc
     3301 ttcaccaggt tttgctccct gtgccatctt aatctgaatt tcctgtgcac ttacaaggta
     3361 acggcttgtt acaccgaaac gaccggaagc tacctgcttg attgcagagc atttattcag
     3421 tccatctgga ccaactgtca gacgctctaa atcttctcca ccttcaccag tgtttgattt
     3481 accgtgaatc atgttcatcg cgattgccag agtctcatgt gcttccttgg aaatagaacc
     3541 ataactcata gcacctgtct taaatcgttt cacgatagaa tctacagatt caacttcttc
     3601 gataggaact cctttggatg gataattgaa atccattaat ccacgaagac ttactggaga
     3661 agtttcttta ttaatcatgg aagtatactg tttaaacagt tcataattat ttgtccatgc
     3721 tgctgtctgt aatgtatgga tggtcagtgg attgtaaaga tgttcttctt taccacttct
     3781 atatttgtga tcaccttcac tgtcaagact aagatcattt ttcagtccta acatatcaaa
     3841 tgctttggag tgatggtaat ctacatcttc tgcgatatct tcaattgtga taccttctac
     3901 acggcttact gtgtttgtaa agtactcatc aatgactttc ttgctgatac caactgcctc
     3961 aaaaatctga gaaccctgat aggactgcag tgtggaaata cccatcttag atgcgatctt
     4021 tacgataccg tgaagtactg cgttattgta atcatttact gctgcatagt aatctttctt
     4081 taataaacca tcctgaatca gcttcttaat actgaactgt gccagatatg ggttgatagc
     4141 acatgcgccg taacctaaca gtgtggcgaa atgatgtact tctcttggtt caccactctc
     4201 taagataata cttacagaag tactcttctt tgtctcaatg agatgatgat gtacagcaga
     4261 tactgctaac agagatggaa ttgccacatg gttctcatca acacctctat ctgtcaaaat
     4321 aacaacattt gcaccatttt tatgcgcctg gtcaacagca acatataaat gattgatagc
     4381 cttatcaagc ggtgttcctt tgtaataagt aatcggcaca tcttttacat tgatattctt
     4441 tacctttgca taacgaatct ttaataagtc tgtatttgtt aaaatagggt tgtgaatctt
     4501 taatacatgg cagttttctg ccttttcttc caacacattc ccctctccgc caacatagat
     4561 ggaagtagat gtaacgattt cctcacgaat cgcatcaata ggagggtttg ttacctgtgc
     4621 aaaaagctgt ttaaagtaat caaataatgg atgatgtctc ttagaaagta ctgctaatgg
     4681 agtatcaacc cccatcgctc cgattgcttc acttccgttt aatgccatcg gtaatacaga
     4741 atctttcact tcttcataag agtaaccaaa tgctttcatc aggcggttgc tctcttcata
     4801 gctgtattct tctactgcaa cattcggaat ctttaagtct tttaagaata caaggttatc
     4861 ggataaccat tcaccgtaag gctgattctt tacataagaa tcttttaaga tttcatcgtc
     4921 aatcagctca ccttttacag tatctacgag aagcatttta cctgggtgaa gtctctcttt
     4981 ctttacgata tgtgttgtgt caaagtctaa caccccaacc tcagaagaaa gaattaactg
     5041 gtcatcatct gtaatatagt aacgggaagg tctaagacca ttacggtcaa gtacggctcc
     5101 catgatatct ccatctgtaa agaggataga tgcaggacca tcccaaggct ccatcattgt
     5161 tgcgtagtac tgatagaagt ctctcttctc tctgctcatg ccctcgttat tttcccaagg
     5221 ttctggaatc gtgatcatca ttgccagagg aagtggcatt ccactcatta agaggaattc
     5281 taatgtatta tctaatcttg cagagtcaga accgtttgga tctacgactg gtgtcagctt
     5341 aatcatctca tccttcagat aatcagattc catgttttcc tcacgggcta acatcttatc
     5401 ggcattacca cgaatagtat taatctcacc attatgaacg atgtaacgat aaggatgtgc
     5461 tttctcccag cttggaactg tgtttgtgga gaaacgggaa tgaactaatg cgattgcaga
     5521 ttcataatcc ttatcctgaa ggtcattata gaataatctt aactgtccaa ctaagaacat
     5581 acctttatat acgattgttc tgctgcttaa agaaacaaca taagcagaat cgttagactg
     5641 ctcaaatact cgtcttacaa tataaagtct tctatcgaag tcaagtcctc gtggaacatc
     5701 aaacggtctc tttacaaatc cctgcataat gcatggcatg cagtccgctg ctttctttcc
     5761 gaggatgccc ggctgaaccg gaacctctct ccagcctaag aaatttaagc cttctttttc
     5821 aacgataatc tcaaacatct tcttagcacg gtttctctgt aactcatcct gtggcataaa
     5881 gaacatacca ataccatagt cacgttcctt gccaatagaa aagccgagag tactacaggt
     5941 tttttcgaag aacttatggg atatctgcac taagatacct actccgtcac ccgttttacc
     6001 ctcggcgtcc ttgccggctc tatgttcaag attttcaaca attttcaagg cattcgatac
     6061 tgtctcatgg ctcttaagac ccttgatgtt tactacagca ccaataccac agttatcatg
     6121 ctccagactt ggatcatata gaccctgtcg catattgtcc tgatacatgg tctcaccctt
     6181 tcttgcatca ctatgaaata gtaaatattc atcagttgta aattatattt ttgtaattag
     6241 taattatcag gaactcttaa tcaaacctta taattctcat gctcttgtga tcttataatc
     6301 tcatgattct gaataaatat ctatagtctg aaaaaatcta taggtctctg aataatcaca
     6361 tatttaaaaa agtaacaaat tcattttcag aagcagtttt aataacttcc tgcatttctt
     6421 tttgttgtta tcatattaca acattttaaa tgggttgtaa atataaacat taaggtgagt
     6481 tgtctaataa tttgattatt tattttttaa tatattattt tctgattatt actcttgttt
     6541 taggggatat tgtagttagt ttatttggtt tttatttctt tttagattat attgttctta
     6601 taaaagtaca attttgtttg tgatttcacc tctttattca tcgttatttt cagatttaaa
     6661 gacaattcat acaattataa atgtaatttt caaatacaaa tcctgcattt tattaacatt
     6721 gtatacaaaa taacttaaga aaattaagta agtaattggt tgaattctac aattttatgc
     6781 cattgtctaa actagcatac tatttgtagt gaaaaagcaa aaaaagaatc ggattctttt
     6841 ttcgtaaact gtcttttcaa aaagaaaatt tccctaatct ctcatactaa tgtaagaaag
     6901 gagattttaa ttacacacat ggcaaatcag agcaatacaa aaagaaaaaa ttatacatat
     6961 taataataat caacaaaaaa tgttgaaatt cgatacagaa aggagaggcc atttcgcaaa
     7021 aaaatacgca tttattatta tagaaaaaag aaaggagaaa tcacaatgat tattaacaaa
     7081 ttttatgaaa aactctacaa ggaacttatc aacaaactag aatctgatta tattttaatc
     7141 cctaacacgc cagaaaatag aaaagcaatt aataatactc taacgacagt cccttgcact
     7201 gtaaaatctt tagaaaaaga ttcaaagatt tttaaagctt tatctaacaa aaaagctaaa
     7261 gctaagcagc tttcaattgt acccaaaatt tctaaaactt tatctcttat tataatagcc
     7321 actttaattt gtatgccatt taataccatt aacactctcc caacgcctac ctaccaccct
     7381 actgtacaag ttagtatttt agatatttct gatggatctt ctcaccaaaa agggaaaaat
     7441 aaattatccg aaatacaaga acaatacaca aacaaaaacc aagagcaacg taatcctaaa
     7501 aactacaaaa agaaagttgc tacaaataca tataatacat ataagaaaca aaataaattc
     7561 catttaacat tatccacaaa aaaagcaact caacttttat caacttttaa aaagtttttt
     7621 cttaaaacaa aaaatacata cgataattta tctgatgctt atgatgtaat tagtacttta
     7681 tttgtattga tttccacagt aaaagaatct atacgctcaa aaaaattaaa atagtccttc
     7741 tatataattt tattcaatac tattttcaat tatacattaa agccgttctt cacagaagta
     7801 cggctttaaa ttttcttatg aaagccaaga tagagtttta aatatcaaaa caatactttc
     7861 ccttgcccct tcctttcaca tctttaatca actcaaattc ccgcattgtt tgaatcagaa
     7921 atcccgcctt actgtcttta tatcccagtt tttgttttat ttcttttcgc ccaaagactt
     7981 cttctcctga aaagctttcg ataatctcct ttatatttaa tgcagtgacg ctacctatgc
     8041 ttttattaac ttgtagttct ttcagctttt tatataacat atatttattc tctgcagtca
     8101 atacagacgt ttcaaaacag tgggttttat cctgacttgt tgtttcaaac agtgtttttt
     8161 catcattcaa acagtatttt ttttcatttc cttgtgaatc cagcgcatta aacagtgatt
     8221 tttctgtatt gaaacagtga ttttgctctc tatattccac tgtttgttct tttactacag
     8281 atgctaagtt ctcactattt atattattca tatactggta tttattttca gcgttctgta
     8341 tattctccgc ccgttttcgc atctccaatt cttcattttc ccggaatata gttactcgta
     8401 taccatctcc cagttcctca aacactggct ctctcaatcc atattctctg cattctttta
     8461 tcattcttgg gattcctgtt ccccacgctt ctataagtcc catataacga aatgcttcag
     8521 caatcgctgt atttctgcac tttgatttac ctgatttagc tgactgtata tccagtcccc
     8581 cataaagcat tccgggagat gttacttcta tcctgtcatc atagacacaa acctgtatac
     8641 aagactcatc caaataactt ctatgaacaa ctgcattagt aatcaattct cttattgttc
     8701 gaaccgggag ttcatacgct tcttttctat gtaacccttc tatctttgca ccaagattga
     8761 tatgctttaa tacaaattga taagcatttt ccagctgtac atataatggt ccatcaaatt
     8821 ctcttttatc tataaaaata tctctttctg ttcctttaaa taacgcacat tgaattttgg
     8881 cataccgtat tttattcttc gtcattagtc taaacgcatg ggtgggttga aggtcttttc
     8941 ctattcggca caataaccct aagtcttcta gtttctcgat tgtcatttta tttataattt
     9001 cagttttttc tgtattttgc ttgggatcta atgacgtttc ctgtattgct cttgttacac
     9061 atgttgtctg cacatcatat gccacttttt ccattgcatt acataatatc ttcgcctctc
     9121 gttccgagta ctccatgtct atttccggta aagtatcata agaaatcttt tgaccttcta
     9181 attctagttc ctttaacttt ctatcatcag caggacgact tgtatcattt attcttatat
     9241 aagaaccttg ttccttccca aatgacttga gataataagg acgcatacgt cctggaaaaa
     9301 cttctacaac aacaactgtt cttccttcta atgtctgtat tgtaatttcc ggatcaatta
     9361 ttggagtgca gctgtcaaat atcatatttg aaatatcatc tgctaatcta aatggattct
     9421 tctctccaat cccaataact tcattcgtct tatcctcaat tccaataaaa attttacccc
     9481 ccgtagaatt ggaaaaagca ataacatctt ttaataactt ctcatgtctt ttcggtatct
     9541 ctcttttaaa ttctatattt tttccttctc caaaatcttc tttatatagc attcctgtcc
     9601 ctcttcaaaa ccattgtcag tacatctatc agtcattaat ttgttatgat ttattataat
     9661 acaattctct tctttttttc aacacacaag aagaagccat gcaccagcat agctagcaca
     9721 cggcttctct tttgtatttt ataaagtttt atcttttgta actaatctga ctgaccagtt
     9781 caggctttat tatttataaa gctcaacgag tctctgcagg tgctcgtaac gagccttagc
     9841 aaccttctca gattcgttga agagtctttc agctctttct gggaatggct taatcagacg
     9901 agtgtaacgg gattcgttat ttaagaattc ctgatatgat ccatcgcctt ctttagatgt
     9961 taatgtgaat ggattctttc cttcagcttt cttagctggg tcgaaggaga agaggttcca
    10021 gtaaccagcc ttaacggctt tcttcatctc atcctggcag tggttcatac cacccttagc
    10081 gataccgtga agttcacatg gagcgtatcc gatgatcagg gatggtccgt tgtaagcttc
    10141 tgcttctgca agacatttaa ctgcctggtt agggttagca ccaagagcaa tctgtgcaac
    10201 gtatacgtat ccgtagctca tagcgatctc tgcaaggctc ttcttgctga tttctttacc
    10261 agctgctgcg aactgacaaa cctcaccgat gttagaagct ttagaagcct gtccacctgt
    10321 gttggagtac atctcagtat cgaataccat aacgtttacg ttctcaccgg aagctaatac
    10381 atggtctaat ccaccgaaac cgatatcata tgcccatccg tcaccaccga agatccatac
    10441 ggacttctta gcgagatact gtttcttctc taatacttct gctgcatctg gacatccagc
    10501 tgctgctgct ttttctacct cagcgattaa tgcctgagca tcaggtgtat tttcttttgt
    10561 attgtctttt gtttccatga acttagcaaa tgctgcttta aattcatcgg atgctttatc
    10621 ggatgctgcc atcttctcta atttagcgat agcctgatca cgtaaagtct tctgtccaag
    10681 atacatacca aagccgtgct ctgcgttatc ctcgaataag gagtttgccc aagctggtcc
    10741 ctgtttggaa tctttgttta ctgtatatgg agctgttgct gcaggaccac cccagatgga
    10801 tgaacatcct gttgcgttgg agatgtacat atgctctccg aataactgag taatcagacg
    10861 agcgtaagat gtctctgcac atcctgcaca agatccggag aactcaagta atggctggtt
    10921 gaactgagat cccttaactg tagtatctgc aggagcacct ggttttcttc caacagttgc
    10981 aactaagtaa tcgaatactg gctgttctgc tgcctggctt tcctgtggaa ccatctttaa
    11041 tgcgccctta gctgcagcag gacaaactgt gatacactca ccacatccca tacagtctaa
    11101 tggagatacg ctcattgtaa atttgtattc gcttgccttt ggctttgtat ctgcaacttt
    11161 catgttgtca ggagctgcct taatttcgtc ttcgcttact aagaaaggac gaattgtagc
    11221 atgggaacat acaaacgcac actggttaca ctggatacaa gcttctggat tccattctgg
    11281 aacagataca gcagtaccac gtttttcgta tgcggaagca ccaagttcga actgtccgtc
    11341 agcgttgtct acgaatgtag atactggcag gctgtcacca tccatgattc cgataggttc
    11401 catcatttcc ttaaccatct taactgtctc tggacgtcct gtaagttctt tagcaggagc
    11461 atcagcagct gggttagacc aggaagctgg aatctctact ttatgaacag catctacacc
    11521 agcgtcgata gctttgtagt tcatctctac aacagcgtca cccttcttgc tgtaggactt
    11581 cttagctgct gctttcatga attctactgc ttcgtcgata ggcatgatgt tcgctaattt
    11641 gaagaatgcg gactgtaaga ttgtgttagt acgtttaccc ataccaatct caatagcctt
    11701 atcaatcgcg ttgattgtgt ataactgaat gttgttgtca gcaatatact tcttagctgc
    11761 tgcaggcata tgatgatcta attcttcatc agaccactgg cagttgatca tgaagattcc
    11821 gcctggttta acatcctgaa ccatcttgta acctttaact acataagatg ggttgtgaca
    11881 tgctacgaag tcagcctgat taatgtagta tgggcttctg attggattgt caccaaaacg
    11941 aaggtgagaa attgtaatac cacctgtctt cttggagtca tactggaagt atgcctgaat
    12001 gtatttatct gtgtggtcac cgatgatctt tgtagagttc ttgttagcac ctacagtacc
    12061 gtctccacca agaccccaga acttacactc tactgtacca ggagcagatg taataggagc
    12121 tggtttaact tctggtaaag ataagtttgt aacatcatcc acgataccaa ttgtgaaacg
    12181 gctctttgga gcgtcttttt caagttcttt ataaatagca aatacagatg aaggaggagt
    12241 atctttagaa cctaatccgt aacgtccagc tgtaagaacg atatcgttaa gacctgcttc
    12301 tctaagagtt gtagcaacat caagatataa aggatctcct aatgctccag gctcttttgt
    12361 acggtcaaga acagcgatct tcttagctgt cttaggaata acgtctaata atgcagaaga
    12421 tacccaagga cgatataaac gaactttgat taaaccaacc ttttcacctt ttgctgttaa
    12481 gtaatcaatt acttcttctg ctacgtcaca gatagatccc atagcgatga ttacgcggtc
    12541 tgcatcttct gcaccatagt agttgaataa atcgtagtta gttcccagtt tttcgttgat
    12601 tttgcccatg tatttcttaa caacagctgg taaagcttcg taaacagagt tacaagcttc
    12661 tctgtgctgg aagaaaacgt caccgttttc gtgagaacca cgcatagctg ggtgttctgg
    12721 gttaagagca tgctcacgga aagctttaac tgcatccatg ttgcacattt cttttaagtc
    12781 tgcataatcc catttttcga tcttctgaat ctcatgagat gtacggaaac catcgaagaa
    12841 gttgatgaat ggaactttac cttcgattgc agcaagatgt gctacagggc ttaagtccat
    12901 aacttcctgt gggttagttt ctgccagcat agcaaatcct gtctgacgac atgcatatac
    12961 gtcactgtgg tcaccgaaaa tgttcagaga ctgtgtagca actgtacgtg cagatacatc
    13021 aaatacacat ggaagctgct cagctgcgat cttatacatg ttagggatca taagaagaag
    13081 accctgggat gctgtaaatg ttgttgtgat agcaccagct gcaagagaac cgtgaacagt
    13141 acctgctgca cctgcctcag actgcatctc actaacaact acctggttac caaaaatatt
    13201 ttcctgtcct gctgctgccc actggtcaac ggaatcagcc attggactag atggtgtaat
    13261 aggatagata gctgcaacat ctgtatacgc atatgctacg tgagctgctg cggtatttcc
    13321 atccatagac tgttttgctc taggcattga ttattcctcc ttgtcaaaag ttgtggttta
    13381 ttttaaattc gacataatat tatcattttt ttgaggtaat gtaaagctta ttcggaactg
    13441 ttccttctaa aatacaaaat cttgcccgaa acagcctttt tatgccaatt tttccccttg
    13501 acaacgtatt tttccgagaa caattttagg ttaaaattgc tataaagcca acagttttgt
    13561 atacaatata catatggctt attttagatt ttttctcaat aattttttgt tgtaatttta
    13621 ggattattca ggattaaaat tctaatattt tttcttcatt ttttaattat tttatgagat
    13681 tcctctttgt tttcaccatt tatctccatc ttttaaaaat aacaatttcg taattttaca
    13741 taatttaatc gactagaacg tgtttgaaaa atgctttctg caagatgtgt gtcaca
//
