LOCUS       gnlProkkaNBNICBIB_63   12003 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|NBNICBIB_63.
ACCESSION   gnlProkkaNBNICBIB_63
VERSION     gnlProkkaNBNICBIB_63
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-01 15:30:48
            Original ID  :: gnl|Prokka|NBNICBIB_63
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12003
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12003
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[823:2489]"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      824..2489
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
     cand_cluster    1..12003
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /kind="single"
                     /product="ranthipeptide"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..12003
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="ranthipeptide"
                     /region_number="1"
                     /rules="(TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085
                     or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /tool="antismash"
     CDS             416..703
                     /locus_tag="ctg63_1"
                     /transl_table=11
                     /translation="MPERTTQNAQTLLSPRVPRDTEHERYHPELEEELKECLFCLKRNE
                     MMFDMEVDTDLIEQRIYERQALLCRYRYLLARARELGLHTVLTRYQPMGG"
     CDS             824..970
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR03973"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: SCIFF"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg63_2"
                     /sec_met_domain="TIGR03973 (E-value: 1.1e-26, bitscore:
                     82.1, seeds: 29, tool: rule-based-clusters)"
                     /sec_met_domain="SCIFF (E-value: 6.3e-26, bitscore: 79.7,
                     seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MERIKTIATRDLTKSVKTGGCGECQTSCQSACKTSCGVANQQCEN
                     SNK"
     CDS             1038..2489
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: Ranthipeptide_rSAM_RRE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR04085"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg63_3"
                     /sec_met_domain="Ranthipeptide_rSAM_RRE (E-value: 3e-31,
                     bitscore: 97.3, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 2.9e-16, bitscore: 49.6,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 8.9e-17, bitscore: 51.5,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 9.8e-21, bitscore:
                     63.6, seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVHQYQLNGYNIVLDTCSGSVHVVDEVAYDVIAMYPKHTADEIVA
                     AMLAKYGSRPDVTEEDLRQCIDDVTSLKENGKLWSPDVYKDMAFDFKNRNTVVKALCLH
                     VAHSCNLSCSYCFASQGRYHGDRALMSFEVGKRAMDFLIENSGTRRNLEVDFFGGEPLM
                     NFEMVKKLVAYCREQEKIHNKNFRFTMTTNGVLIDDDVIDFCNKECHNVVLSLDGRKEV
                     NDRFRVDCAGNGSYDRIVPKFQEFVKKRGDKNYYMRGTYTHFNTDFTNDIFHMADLGFT
                     ELSMEPVVCDPSDPSALTEADLPILKEQYEILAKEMIKRDREGRGFTFYHYMIDLTGGP
                     CIYKRISGCGSGTEYMAVTPWGDLYPCHQFVGDPKYLLGDIWKGVTNTAVRDEFKHCNA
                     YARKECQDCWAKLYCSGGCAANSYHATGSITGVYEYGCELFKKRMECAIMIKVAENQEL
                     AAKGIEVPIELGSTCNACADGEACE"
     CDS             2486..3904
                     /locus_tag="ctg63_4"
                     /transl_table=11
                     /translation="MSMTTPIVDFVRSYAKSGTARLHMPGHKGQSLLGFEPLDITEICG
                     ADELYAPEGIIAESEANATRLFGTAHSYYSTEGSSQCIRAMLFLALQGAPQNGRRPVLL
                     AARNAHKALLYAAALLDFDIRWLWPSAQAEGALCSCPVTAEALTGALHALAQQGNTPFG
                     VYVTSPDYLGGVQDIPALAAVCRAQGVPLLVDNAHGAYLRFLPQNCHPIAQGAAMCCDS
                     AHKTLPVVTGGAYLHLAHDAPVQDEAAVRGALALFGSTSPSYLILQSLDACNAVLAGDY
                     PRQLAQCCAALENLRRSLNKAAAARQCPVPLAVAGAQQEPMKLTLDAAALGCTGIALAE
                     ALRRAQMECEYADPRYVVLMFTPENPPQDFERLQTALEQLLAAVPAGLPRPENRAGEFA
                     ALQQQAVQCCTIRQAVLGAQVRIPVHKALGRVCAMPTVSCPPAIPVAVSGEEITPAAIA
                     LMQRYGIEELSVLR"
     CDS             complement(3966..4643)
                     /locus_tag="ctg63_5"
                     /transl_table=11
                     /translation="MTDLPFVSALVQADLPVWEQCLQTEFLQKMENGILSEDCFKSYLV
                     EDSLYLREYAKIFAWGMTKATTMAAMRTYYSLLSFVQENEDLTRLRYLEQYGLREADIQ
                     SLPLRPESRAYLDCMIDAARTGEGEAECLMACLPCMLSYGWLFQKLLQRSPAVKDTYYG
                     ALVLDYAGPGYDAACRAWAERAEVACTGLSPERAARCRAIFRACSEHELHFWEMCAAPR
                     TDI"
     CDS             complement(4636..5436)
                     /locus_tag="ctg63_6"
                     /transl_table=11
                     /translation="MKTALTIAGSDSSGGAGIQADIKTMTANGVFAMSAITALTAQNTT
                     GVTAIFDTTPQFLAQQLDAVFTDIYPDAVKIGMVSSAPLIDTIAERLHFYGAKHIVVDP
                     VMVATSGAKLLQDDAVQALTEKLLPLAEVLTPNIPEAEILSGMSIANAADMEAAARTIS
                     ERYGCAVLCKGGHQINDADDLLWQGGTGKWFKGKRIANPNTHGTGCTLSSAIASNLAKG
                     YDLDTAVERAKAYISGCLSAMLDLGHGSGPMDHTFNLKGDFVRD"
     CDS             complement(5658..6554)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) 2-Hacid_dh_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1072:dehydrogenase (Score: 97.2; E-value: 1.3e-29)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg63_7"
                     /sec_met_domain="2-Hacid_dh_C (E-value: 9.2e-18, bitscore:
                     53.7, seeds: 135, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFEKLVAIEPVSLIPSAEEELHRYAKEVVLYRDVPASDDEMVRRI
                     GDADAVLLSYTSRMGKEVIAQCPNIRYIGMCCSLYSEESANVDIAYARTRGIQVLGIRD
                     YGDRGVVEYVLHELTGLLHGFGMPMLRDEPVEITGLKVGIVGLGVSGRMIADALQFMGA
                     EISYFARSAKPDAEAAGMTFKPLAQLLAESEVVFTCLNKNVLLLGENEFTQLGAGKVLF
                     NTSIGPGFDSAALEKWLDLPGTRFFCDTRAAAGPVAEDFFARENVRCANVSAGRTKQAF
                     VLLSKKVLDNIRTALGE"
     CDS             complement(6573..7373)
                     /locus_tag="ctg63_8"
                     /transl_table=11
                     /translation="MKTKLGIVGCGFLGNIVADAWKKGLLPDYELVGVTSRTRASAEKT
                     AANVGCAVCEDVDALLALEPEYIVEAASVESVRAMAIPVLKRGVNLVILSIGAFADLDF
                     YAQVKAAAVAGGAKVHLASGAIGGFDVLQTVTLMAQAQGLPETAGIETHTGAKGFRNTP
                     VWAEHLLTDTEKTTVFTGNAKQAIATFPRRVNVAVAISLATTGPESTCVTMHSVPGWVG
                     DDHCITAKIEGVKAVVDICSSTSAIAGWSAVSLLRNLASPVCFY"
     CDS             8168..9682
                     /locus_tag="ctg63_9"
                     /transl_table=11
                     /translation="MAYFYEEPSRTFGEYLLVPGYSSAENVPTAVSLKTPLVKYRKGQE
                     ECPLQMNIPMISAIMQSVSGDKLAIALARQGGVSFIYGSQSIENEAAMVRRVKSFKAGY
                     VVSDSNLAPTATLHDVLELKARTGHSTIAITADGTPNGKLLGIVASRDYRINHTPDDAC
                     VTTFMTPVEKLVTAPANTSLHDCNNIIWDNKINTLPLVDAEGNLVYMVFRKDYDSHKAN
                     VNELLDKNKSYVVGAGINTRDYAQRVPALVEAGVDVLCIDSSEGYSEWQSRTIGWIREH
                     YGDTVKVGAGNVVDAEGFRFLAEAGADFVKIGIGGGSICITRETKGIGRGQATAVIEVA
                     KARDEYYKETGIYVPICSDGGIVHDYHITLALAMGADFVMLGRYFARFDESPTNKVRIN
                     GQYMKEYWGEGSNRARNWQRYDLGGSTKLSFEEGVDSYVPYAGPLADGVQTTLYKVKST
                     MCNCGALSIPELQQKAKLTVVSSTSIVEGGSHDVVLKNATPSIMNG"
     CDS             9906..11423
                     /locus_tag="ctg63_10"
                     /transl_table=11
                     /translation="MNEIKVEPYIPDEDYDNPAMVVDFYEFTMANCLFLHGFKNTTLVF
                     DMFFRKNPDNQGYSISAGQRKLTRFLLDYHFNEQDIHWLRTKGMSEEFCEYLRTYKWKG
                     DMYALPEGTVCYPHVQMVRIECDLVGAILIETYLLQTMNFHSLIATKATRVTGLNTHTP
                     RNVMEFGTRRAQGESAGNDGAYAAVLGGCIGTANCLAEMKFGAEVKAVGTVAHSFIEFF
                     PTEFDAFKAFADTYPDSVSLLLDTYNIMESGLPNLIKLDDYLIEKYPNDPNRRVKSARI
                     DSGDLARGSKRLRKALDAAGKPYIKLVASNGLDEKKIANMELYEHAHFDSYGVGENLIT
                     SASDPVFGGVYKLVAVKKPDGSYTPKMKCSDSASKAIIPGKKMPWRLYDENGQAQCDLI
                     AMDGEVIEAGKPVTMVNLDSDAIERTITFIPTAVRPLLVPHILGGELAIELPSIAEKKA
                     YIAKQLTEETWESELRLECPHKHYVNMTPAVAECRSRMYAELHGGKV"
     CDS             complement(11887..12003)
                     /locus_tag="ctg63_11"
                     /transl_table=11
                     /translation="MYVDAPDKSSGKRVQHIHIKYDGLGYIPLDELEAKEKA"
ORIGIN
        1 aagtggtaat agagttatga ctcttcaagt tttgaagagt cacggccttg cggctgtggt
       61 tcggaatgat ataaacagaa aagccacctg aacttcctca gatggcttta atctggttgg
      121 ggatgagaga atcgaactcc cacaagtaga gtcagagtct accgcactac cactatgcaa
      181 atccccaata ttctgttgtg ttttgcgggg tgagccgctc aacgtgtgct attatacggg
      241 aaaagcccgg agttgtcaag catatttttg aaaaaagttg tacttttttg gaaaatgccg
      301 cagcagcgcc ggataatcta tgccggagcg ctgccacact tcggcaggtt ctgcacactg
      361 caccgcctat actggaaggt acaaaacctt acaaagcacc agaaggagga tgcctatgcc
      421 ggaacgaacc acacagaatg cccagaccct gctttcgccc cgcgtcccgc gggataccga
      481 gcacgagcgc taccatccgg aactggagga ggaactgaag gaatgcctgt tctgtttgaa
      541 gcgcaacgag atgatgtttg acatggaggt ggatacggac ctcatcgagc agcgcatcta
      601 cgagcggcag gcgctgctgt gccgctaccg gtacttactg gcgcgcgccc gggagctggg
      661 gctgcacacg gtgcttaccc gctaccagcc catgggcggg taaaaaggct tagcgaaaaa
      721 atcttgacaa aagccgcgct gcgtgatatt ctattacaag ataaaagcgt accggaacta
      781 tgtccggcgc gataaatttt tgagagttag agaggtttct atcatggagc gtattaagac
      841 tattgctact cgtgacctga ccaagagcgt taagaccggt ggctgcggcg agtgccagac
      901 ttcctgccag tccgcctgca agacctcctg cggcgtggct aaccagcagt gcgagaacag
      961 caacaagtaa tttttgcaaa ccctatgccg cctttgccgg gcggcatttt tttgtgtaat
     1021 ctggaatgga gtgtaaaatg gtacatcagt atcaattgaa cggttataac atcgtgctgg
     1081 acacctgcag cggctcggtg cacgttgtgg acgaggtggc ctacgatgtc atcgccatgt
     1141 acccgaagca taccgcagac gagatcgttg ccgccatgct ggcaaaatac ggcagccgcc
     1201 cggacgtgac cgaggaggat ctgcgccagt gcatcgacga cgtgaccagc ctgaaggaaa
     1261 acggcaagct gtggagcccg gatgtctata aggacatggc ttttgacttc aagaaccgca
     1321 acaccgtggt aaaggcgctg tgcctgcacg ttgcccatag ctgcaacctg agctgctctt
     1381 actgctttgc ctcgcaggga cgctaccatg gcgaccgcgc cctgatgagc tttgaagtgg
     1441 gcaagcgcgc catggacttc ctcatcgaga acagcggcac ccgccgcaat ctggaagtgg
     1501 acttctttgg cggtgagccg ctgatgaact ttgagatggt caaaaagctg gtggcctact
     1561 gccgcgagca ggaaaagatc cataacaaga acttccgctt taccatgacc accaacggtg
     1621 tgctcattga tgacgatgtt atcgacttct gcaacaagga gtgccacaac gtggtgctga
     1681 gtctggacgg ccgcaaggag gtcaacgacc gcttccgcgt ggactgcgca ggcaatggca
     1741 gctacgaccg catcgtgccc aagtttcagg agttcgtcaa gaagcgcggc gacaagaact
     1801 actatatgcg cggcacctat acccacttta acaccgactt taccaacgat atcttccaca
     1861 tggcagacct tggctttacc gagctgagca tggagccggt ggtctgcgac cccagcgacc
     1921 ccagcgcctt gactgaggcc gacctgccca tcctgaagga gcagtacgag atccttgcca
     1981 aggagatgat caagcgcgac cgcgagggca gaggctttac cttctaccac tacatgatcg
     2041 acctgaccgg cggcccctgc atctataagc gcatctccgg ctgcggctcc ggcaccgagt
     2101 acatggctgt taccccctgg ggcgatctgt acccctgcca ccagttcgtg ggcgacccca
     2161 agtacctgct gggcgatatc tggaagggcg ttaccaacac cgccgtgcgg gatgagttca
     2221 agcactgcaa cgcctacgcc cgcaaggagt gtcaggactg ctgggcaaag ctgtactgct
     2281 ccggcggctg cgctgccaac tcctaccacg ccaccggcag cattaccggc gtgtacgagt
     2341 acggctgcga gctgttcaaa aagcgcatgg agtgcgccat catgatcaag gtagccgaga
     2401 atcaggaact ggcagccaag ggcatcgagg tgcctattga gctgggctct acctgcaacg
     2461 cctgcgccga tggcgaagcc tgcgaatgag catgaccacc cccatcgtgg attttgtgcg
     2521 cagctatgca aagtccggta ccgcccggct gcatatgccc ggccacaagg ggcagagcct
     2581 tttaggcttt gagccgctgg atatcaccga gatctgcggt gcggacgagc tttacgcgcc
     2641 ggagggcatt attgccgaga gtgaagccaa cgccacccgg ctgttcggca cggcgcacag
     2701 ctattacagc actgagggct cgtctcagtg catccgtgcc atgctgtttc tggcgctgca
     2761 aggcgcaccg caaaacggca ggcgcccggt gctgctggct gcccgcaacg cccacaaggc
     2821 gctgctgtac gcggcggcgc tgctggattt tgatatccgc tggctttggc cgtctgcgca
     2881 ggcagaaggt gcactgtgca gctgccccgt cacagccgaa gcgctgacag gggctttgca
     2941 cgcgctagca cagcagggca acaccccctt tggcgtgtac gtcaccagcc cggattatct
     3001 gggcggggtg caggatattc cggcgctggc ggcggtctgc cgggcgcagg gcgtgccttt
     3061 gctggtggat aacgcccacg gcgcctacct gcgctttctg ccgcaaaact gccaccccat
     3121 cgcacagggc gcggccatgt gctgcgactc tgcccacaag accctgccgg tggtcaccgg
     3181 cggtgcgtat ctgcatctgg cgcacgatgc ccctgtgcag gacgaagcgg ctgtgcgggg
     3241 ggcgctggcg ctgttcggct ctaccagccc ctcttacctc attttgcagt cgctggatgc
     3301 ctgcaacgcg gtgctggcag gggactaccc ccggcagctg gcgcagtgct gcgctgcgct
     3361 ggagaatctg cgccgcagcc tgaataaggc cgcagcggcg cggcagtgtc cggtgccgct
     3421 ggcagttgcc ggggcacagc aggagccgat gaagctcacg ctggacgccg ctgcccttgg
     3481 ctgcaccggc atagcgctgg cagaggcttt acgccgcgca cagatggagt gcgagtacgc
     3541 cgacccccgc tatgtggtgc tgatgttcac cccggaaaac ccgccgcagg actttgaacg
     3601 cctgcaaacg gcgctggaac agcttctggc ggctgtgcct gccgggctgc cccgcccgga
     3661 gaaccgggca ggggagtttg ccgccttgca gcagcaggcg gtgcagtgct gtaccatccg
     3721 gcaggcggtg ctgggcgcac aggtacgcat cccggtgcac aaggcgctgg gacgggtgtg
     3781 tgccatgcct acggtgtcct gcccgcccgc catccctgtg gcggtcagcg gcgaggagat
     3841 caccccggcg gccatcgccc tgatgcagcg ctacggcatc gaggaactct cggtgctgcg
     3901 ataaagattt tataagaaga gaacccggaa ggtctgcgga ccttccgggt tctctatatt
     3961 tatttttaaa tatccgtccg gggtgcggcg cacatctccc agaagtgcag ctcgtgctcc
     4021 gagcaggcgc ggaagatcgc gcggcagcgg gcggcacgct ccggcgaaag gccggtgcag
     4081 gccacctcgg cgcgttctgc ccatgcacgg caggcggcat catagccggg accggcgtag
     4141 tccagcacca gcgcgccgta gtaggtgtcc tttacggcgg gggagcgctg caaaagcttc
     4201 tggaatagcc acccgtaact cagcatacag ggcaggcagg ccatcaggca ctcagcttcc
     4261 ccctcgccgg tgcgggcagc atcgatcatg cagtccagat aggcgcggct ttccgggcgc
     4321 aggggcaggg actggatatc ggcttcccgc agaccgtact gctccagata ccgcagccgg
     4381 gtcaggtcct cgttctcctg cacgaaggac agcagggaat agtaggtgcg catagccgcc
     4441 atggtggtgg ccttggtcat gccccaagca aagatcttag cgtactcccg cagatacagg
     4501 ctgtcctcca caaggtagct tttaaagcag tcctcgctca ggatgccgtt ttccatcttt
     4561 tgcaaaaact cggtctgcag gcactgctcc cacacaggca ggtcagcctg caccagcgcc
     4621 gagacaaagg gcaggtcagt cacggacaaa atctcccttc aggttgaagg tgtgatccat
     4681 gggcccggag ccgtgcccta agtccagcat ggcagacaga cagccggaaa tgtaggcctt
     4741 ggcgcgctcc acggcggtat caaggtcgta ccccttggcc agattggagg caatggcgct
     4801 ggacagggtg cagccggtgc cgtgggtgtt ggggtttgca atgcgcttgc ccttgaacca
     4861 cttgccggtg ccgccctgcc acagcaggtc gtcggcatcg ttgatctggt gaccgccctt
     4921 gcacagcacg gcgcagccgt agcgctcgct gatggtgcgg gcagcggctt ccatgtcggc
     4981 ggcgtttgca atgctcatgc cggacaagat ctcggcctcc gggatgttgg gggtaagcac
     5041 ttcggccagc ggcagcagct tttcggtcag cgcctgcacg gcatcgtcct gcagcagctt
     5101 tgcaccggag gtggccacca tcacagggtc caccacgatg tgctttgcgc cgtaaaaatg
     5161 cagccgctcg gcgatggtgt cgatgagcgg ggcagaggat accatgccga tcttcaccgc
     5221 atccgggtaa atgtcggtga acacggcatc gagctgctgt gccagaaact gcggcgtggt
     5281 gtcaaaaatg gcggtcacgc cggtggtgtt ctgtgcggtc agggcggtaa tggcgctcat
     5341 ggcaaacacg ccgttggcgg tcatggtctt gatatcggcc tgaattccgg cgccgccgct
     5401 ggaatcactg ccggcaatgg tcaatgcagt tttcatgggt aaaatgctcc tttgcagcaa
     5461 aaatgcggat atgcccgcaa agacatatcc gcagataaaa gcgctatctc cctacgttgg
     5521 catgatccaa atcaggtcac aggtcagggc agtacagccc actctcagcc cgcttgcacg
     5581 ggctcccttt ttatactaga aagcatacca caatcgggga aaagatgcaa gaaaaacagg
     5641 ctgcgcaaac gcaccgctta ttcgcccagt gcggtgcgga tattgtccag cacctttttg
     5701 ctcagcagca caaaagcctg cttggtgcgg cctgcggata cattggcgca gcgcacgttt
     5761 tcccgggcaa agaagtcctc ggccacgggg ccagcggcgg cgcgggtgtc gcagaagaag
     5821 cgggtgccgg gcagatcgag ccacttttcc agcgcagcgg aatcaaagcc ggggccgatg
     5881 gaagtgttga acagtacctt gcctgcaccc agctgggtaa actcgttttc gcccagcagc
     5941 agtacgttct tgttcaggca ggtgaacacc acctcgctct cagccagcag ctgagccagc
     6001 ggcttaaagg tcataccggc agcctcggcg tccggctttg cgctgcgggc aaagtaactg
     6061 atctctgcgc ccataaattg cagcgcatcg gcgatcatcc ggccggaaac acccagcccc
     6121 acgatgccca ccttcaggcc ggtgatctcc accggctcgt cccgcagcat aggcatccca
     6181 aaaccgtgca acagaccggt cagctcgtgc agaacatact ccacaacgcc gcggtcgccg
     6241 taatcccgga tgcccagcac ctgaatgccc cgggtgcgtg cgtaggcaat atccacgttg
     6301 gcgctttcct cagagtacag gctgcagcac atgccgatat agcggatgtt ggggcactgc
     6361 gcaatgactt ccttgcccat gcgggaggtg tagctcagca gcacggcgtc ggcgtccccg
     6421 atgcggcgca ccatctcgtc gtcgctggca ggcacgtccc ggtacagcac cacctctttg
     6481 gcgtagcggt gcagctcctc ctcggcagag gggatcaggc tgacaggttc aatggcaaca
     6541 agcttttcaa acatgacgga ctcctcctta tattagtaga agcagacggg cgaggccaga
     6601 ttgcgcagca gagagacggc gctccagccc gcaatggcgc tggtggaaga gcagatatcc
     6661 accacagcct tcacgccctc gatcttggca gtgatgcagt ggtcgtcgcc cacccagccg
     6721 ggcacggagt gcatggtcac acaggtgctc tcggggccgg tggtggccag agagatagcc
     6781 actgccacgt tcacccggcg ggggaaggta gcaatggcct gctttgcatt gccggtgaac
     6841 acggtggtct tttcggtgtc ggtcagcaga tgctctgccc acaccggggt gttgcggaag
     6901 ccctttgcac cggtatgggt ctcgatgccg gcagtctccg gcaggccctg cgcctgtgcc
     6961 atcagggtga cggtctgcag cacatcaaag ccgccgatag cgccgctggc cagatgcacc
     7021 ttggcgccgc ccgccacggc ggctgccttg acctgtgcgt agaaatccag atccgcaaag
     7081 gcaccgatgg acagaatgac cagattgacg ccccgcttca gcaccgggat ggccatggcg
     7141 cgcaccgact ccaccgaggc cgcctccacg atgtactccg gttcaagcgc cagcagcgcg
     7201 tccacatcct cgcagacggc gcagccgaca ttggcggcgg tcttttcagc cgaggcgcgg
     7261 gtgcggctgg tcacgcccac cagctcgtag tccggcagca gacccttctt ccacgcgtca
     7321 gccacgatgt tgcccagaaa accgcagccc acaataccca attttgtttt cataccgtat
     7381 cctaaactcc ttttttctgc ctgtggcagc atattcatac ccagtatacc ataccgggta
     7441 caaaaaggga aatgatgttt gcagcagctt atggaaatca atttttgcag tttgccacga
     7501 agcaaaagcc ttcacccctt ggggggaagg tggctgcgaa cgcagtgagc agacggatga
     7561 ggggtaacta cgcaacagcg ccctcatcag tcacctgcgg tgacagcttc ccccggccag
     7621 gggaagcctt taaaggaaaa tatgctctca gaaagaggac ataaaaagtt aacaaaataa
     7681 attacaaaaa aattacaaaa ccctattgca aaatggtttc aaaagagtta caatatggtt
     7741 acagcaaggg caaagcccca aggctgtgtg tgaaatcttt ttcttcttgt tttttgggat
     7801 actgggcgcg ggtcctcctc ctccggctgt tctccttcac agctatgacc catgcgccgc
     7861 acaggcagtg tcccgcttcg tgtgcaaaag ggctcgtccg gtgtttcgga cgagcttttt
     7921 tgcattccgt aagcctgatt tggcttgcaa aagtgatact tcaaaaatca aagtatgacc
     7981 aatgcccgaa aacgcttggc aatttgtctg tttttccgca aaggacaatt ataaagtttg
     8041 gcgcggcagg ggtttgtatt cttgcgggct ttgtggtaaa gtatatacaa tcaatttata
     8101 agcagcaaac atgaatgatt ttgatgctga tttgtatcgg atgcgttaag agaaaaggag
     8161 tttgattatg gcttatttct acgaagaacc ctcccgcacc tttggcgagt acctgctggt
     8221 ccccggctat tcctctgcgg agaatgtgcc cacggcggtc agcctgaaga ccccgctggt
     8281 caagtaccgc aagggacagg aggagtgccc gctgcagatg aatatcccca tgatcagcgc
     8341 catcatgcag tcggtctccg gcgataagct ggccattgca ctggctcgtc agggcggcgt
     8401 ttcctttatc tatggctctc agagcattga gaacgaggct gccatggtgc gccgcgtcaa
     8461 gagcttcaaa gccggttatg tggtgtccga ttccaatctg gctcccactg ccaccctgca
     8521 tgatgtgctg gagctgaagg cacgcaccgg ccactccacc atcgccatca ctgccgacgg
     8581 cactcctaac ggcaagctgc tgggcatcgt ggcttcccgc gattaccgca tcaaccacac
     8641 cccggacgat gcctgcgtta ccacctttat gacccccgtt gaaaagctgg tcaccgctcc
     8701 ggccaacacc tccctgcacg actgcaacaa catcatctgg gacaacaaga tcaacaccct
     8761 gccgctggtg gatgccgagg gcaatctggt gtatatggta ttccgcaagg actacgattc
     8821 ccacaaggca aacgtcaacg agctgctgga taagaacaag agctacgttg taggcgccgg
     8881 catcaacacc cgcgactacg cccagcgcgt gcccgcactg gtagaggccg gtgtggatgt
     8941 gctatgcatc gactcctctg agggctactc cgagtggcag agccgcacca tcggctggat
     9001 ccgcgagcac tacggcgaca ccgtcaaggt gggtgccggc aacgtggtgg acgccgaggg
     9061 cttccgcttc ctggctgagg ctggcgcaga cttcgtgaag atcggcatcg gcggcggctc
     9121 catctgcatc acccgcgaga ccaagggcat cggccgtggt caggctaccg ctgtcatcga
     9181 ggttgccaag gctcgtgacg agtactacaa ggagaccggc atctatgtgc ccatctgctc
     9241 cgacggcggc atcgtccacg actaccacat caccctcgcg ctggctatgg gcgcagactt
     9301 cgtgatgctg ggccgctact ttgcccgctt tgacgagagc cccacgaaca aggtgcgcat
     9361 caacggccag tatatgaagg agtactgggg cgagggctcc aaccgtgccc gcaactggca
     9421 gcgctatgac ctgggcggct ccaccaagct gagctttgag gagggcgtgg acagctatgt
     9481 gccttacgcc ggtcctctgg cagacggcgt gcagaccacc ctgtacaagg tgaagagcac
     9541 catgtgcaac tgcggcgctc tgtccatccc cgagctgcag cagaaggcca agctgaccgt
     9601 tgtttcttcc acctccatcg tggagggcgg cagccacgac gttgtgctga agaacgccac
     9661 ccccagcatc atgaacggct aagcctgttc tgaaaagaat ctattaattt aagcgcagag
     9721 accgctgcac agcgtttgtg cagcggtctt tttgcgcgaa aatacttgca ccggcagggg
     9781 aatcgtgcta tcatgataga aacgctctgt catgacaggg cggaggatcc ccctgccggg
     9841 caagcggcag gcggcgcgca gtagggaaga gctgacgccg ggtataaata gagaggaaaa
     9901 cattcatgaa cgagatcaag gttgagcctt atatccccga tgaggactac gataaccccg
     9961 cgatggtggt ggatttttat gaattcacca tggcaaactg cctgttcctg catggcttta
    10021 agaataccac gctggtgttt gatatgttct tccgcaaaaa cccggataat cagggctatt
    10081 ccatcagcgc aggccagcgc aaactgaccc gctttttgct ggactatcac ttcaatgagc
    10141 aggatatcca ctggctgcgc accaagggca tgagcgagga gttctgcgag tatctgcgca
    10201 cctacaagtg gaagggtgat atgtacgccc tgcccgaggg cacggtctgc tacccccatg
    10261 tgcagatggt gcgcatcgag tgcgatctgg tgggcgcgat cttgatcgag acctacctgc
    10321 tgcagaccat gaacttccat agcctgatcg ccactaaggc cacccgcgtc accggtctga
    10381 acacccacac cccccgcaac gtcatggagt tcggtacccg ccgcgcacag ggcgagagcg
    10441 ccggtaacga tggcgcttac gccgcagtgc tgggcggctg catcggtacg gccaactgtc
    10501 tggccgagat gaagttcggc gcagaggtca aggccgtggg caccgtggca cacagcttta
    10561 tcgagttttt ccccaccgag ttcgatgcct tcaaggcctt tgccgatacc tacccggatt
    10621 cggtcagcct gctgctggat acctataata ttatggagag cggcctgccc aacctgatca
    10681 agctggacga ttatctcatt gagaaatacc ccaacgaccc caaccgccgc gtcaagagcg
    10741 ctcgcatcga ctccggcgac cttgcccgcg gctccaagcg gctgcgcaag gcactggatg
    10801 ccgccggtaa gccctacatc aagctggtgg cctccaacgg tctggatgag aagaagatcg
    10861 ccaacatgga gctgtacgag cacgcacact tcgactccta cggcgtgggc gagaacctca
    10921 tcacctctgc ctccgacccc gtgttcggcg gcgtatacaa gctggtggcg gtgaagaagc
    10981 cggacggcag ctacaccccc aagatgaagt gctcggactc cgccagcaag gccatcatcc
    11041 cgggcaaaaa gatgccgtgg cgtctgtacg atgaaaacgg tcaggcacag tgcgacttga
    11101 tcgctatgga cggcgaggtc atcgaggccg gtaagccggt cactatggtc aatctggact
    11161 cggacgccat cgaacgcacc atcaccttta tccccaccgc tgtgcgccca ctgctggtgc
    11221 cgcatattct gggcggcgag ctggccattg aactgccctc tattgcagaa aagaaagcct
    11281 atattgcaaa gcagctcacc gaggagactt gggagagcga gttgcgtctg gaatgccctc
    11341 acaagcacta cgtcaacatg acccccgcag tggccgagtg ccgctcccgg atgtacgccg
    11401 agctgcacgg aggcaaggtg taagcagcac cgaataagcg gtttttcttg acaaaacagg
    11461 gaaactattg tatcataaaa gccgctgatt taataaaaat gttaatacca ccagattgcg
    11521 aatagcagtg tggttgtaat aatttttcct cacacctgtt attcccggct ctctctcaag
    11581 ccagagggca gcaggacttt gtaagccggg gttgcgccgc tgtggtgaaa ttggcagaca
    11641 cgagggactt aaaatccctt tctggagaca gagtacgggt tcgacccccg tcggcggcat
    11701 gtagaagctc agaattgttc gttgatccga atgattctgg gcttttcctt tttgttccat
    11761 tttctggaag tgttgagcgg gcgagaggga tttttcgcga aaaaaggagg agtctctcta
    11821 gcagagttcc cataaaacag tatttgcaaa agttccctaa atggggaaga tttggcgtga
    11881 cttcggtcac gccttttctt ttgcttccag ttcatccaga gggatgtacc ccagcccatc
    11941 gtacttgata tggatgtgct gcacccgctt tccgctggac ttatccgggg catccacata
    12001 gat
//
