LOCUS       gnlProkkaKCDNGBBH_83   10240 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|KCDNGBBH_83.
ACCESSION   gnlProkkaKCDNGBBH_83
VERSION     gnlProkkaKCDNGBBH_83
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-01 15:25:56
            Original ID  :: gnl|Prokka|KCDNGBBH_83
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 10240
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10240
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[126:6188]"
                     /cutoff="20000"
                     /detection_rule="(APE_KS1 or APE_KS2)"
                     /neighbourhood="20000"
                     /product="arylpolyene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      127..6188
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(APE_KS1 or APE_KS2)"
                     /neighbourhood="20000"
                     /product="arylpolyene"
                     /protocluster_number="1"
     cand_cluster    1..10240
                     /SMILES=""
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(APE_KS1 or APE_KS2)"
                     /kind="single"
                     /product="arylpolyene"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10240
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="arylpolyene"
                     /region_number="1"
                     /rules="(APE_KS1 or APE_KS2)"
                     /tool="antismash"
     CDS             complement(2..121)
                     /locus_tag="ctg83_1"
                     /transl_table=11
                     /translation="MEELIEKLKVELIEALNLEEITPEDIDSEAPLFGDDGLGL"
     CDS             complement(127..1857)
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (127-378). E-value:
                     1.9e-24. Score: 78.2. Matches aSDomain:
                     nrpspksdomains_ctg83_2_PKS_KS.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     arylpolyene: APE_KS2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 161.5; E-value:
                     5.2e-49)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg83_2"
                     /sec_met_domain="APE_KS2 (E-value: 3.7e-125, bitscore:
                     407.5, seeds: 16, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEHHLTTYITHDTLISALGFSTQENLEAIRAYHSGITLQTDKRIA
                     DTPLLAATISQERLQQQAETAGISAYTRMEQLFILTINDLIRQSGQTLEDKTCGLILST
                     TKGNIDLLTRHTEHPDEAVFLWKMAENIAGYFHAEERVHVISNACISGVSALVTGKRMI
                     ENGIYRKVIVAGGDLLSHFITSGFLSFRSLSSRPCRPYDSNRDGLNLGEACGAVLLSTE
                     KTPNSIILSGGAISNDANHISGPSRTGDGLFFAIRQAMQEAGTALQNISFVNAHGTATV
                     YNDEMESKALTLAHLEQVPTHSLKPYFGHTLGASGIIESIVCMHELKQGILFGTPGYET
                     PGVPMPIPVYATHQHIPMKHCVKTASGFGGCNAAIVLSLPEYAPFKDEDNTLPEIRCTR
                     EVRIENSSVFINNELIFHSEEPDFGIFIRDTYKKSGGNNMKFYKMDDLCKLGYVAAEYL
                     LKDKTFAPLEMGMLLANATSSLHTDIRHQQLIDQDGDRAASPAVFVYTLPNVVSGEICI
                     RHKIQGENTFFITEAYQPEKLERYARIVMQKGKLNYCIIGWCELLKNTYKAVFKLIEKQ
                     "
     aSDomain        complement(724..1476)
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg83_2_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="1.90E-24"
                     /label="ctg83_2_PKS_KS.1"
                     /locus_tag="ctg83_2"
                     /protein_end="378"
                     /protein_start="127"
                     /score="78.2"
                     /tool="antismash"
                     /translation="MAENIAGYFHAEERVHVISNACISGVSALVTGKRMIENGIYRKVI
                     VAGGDLLSHFITSGFLSFRSLSSRPCRPYDSNRDGLNLGEACGAVLLSTEKTPNSIILS
                     GGAISNDANHISGPSRTGDGLFFAIRQAMQEAGTALQNISFVNAHGTATVYNDEMESKA
                     LTLAHLEQVPTHSLKPYFGHTLGASGIIESIVCMHELKQGILFGTPGYETPGVPMPIPV
                     YATHQHIPMKHCVKTASGFGGCNAAIVLS"
     CDS             complement(1842..2285)
                     /locus_tag="ctg83_3"
                     /transl_table=11
                     /translation="MKRKTSPQQAALTDRTTIKVRFSEIDSMQIVWHGEYVRYFEDGRE
                     AFGKRYGLDYMSIYREGYVVPIVDLSCQFKQSLSFGEEAIVETRYIHSDAAKILFEYTI
                     YRASDQNIVATGTTTQVFLNTNRELELVNPAFYIEWKKKWNII"
     CDS             complement(2282..2719)
                     /locus_tag="ctg83_4"
                     /transl_table=11
                     /translation="MNRKEIICRGDELFRLIPQRPPMVMIDRFYGIEENTSWSGLTVTP
                     DNLFCRDGVLQETGIIEHIAQSAAARVGYIYMLREEPVPLGFIGSVEKMKIFRLPSAGA
                     ELYTGITIVQEIFDITLITAEVKENDELLAECRMKIYLKKE"
     CDS             complement(2716..3786)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042:O-methyltransferase (Score: 113.1; E-value:
                     2.8e-34)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg83_5"
                     /transl_table=11
                     /translation="MMHKRYTKEQLTAVEAQRLAQEIAFGPVVFQVSRLMLKFGIFQLL
                     ADKRKGYTLQEISVQTGLTRYAAQVLLEASLTIGTILLEEDRYVLAKAGWFLLNDKMAR
                     VNMEFNHDVNYQGLFYLEEALLNGQPEGLKVFGGWPTIYEGLSQLPEQVQKSWFGFDHF
                     YSDNSFSQALEIVFLHSPKRLLDIGGNTGRWATRCVQYNQEVEVTIVDLPQQLEMMRKQ
                     TADVPGAERIHGHGANLLDRTVPFPSGFDTVWMSQFLDCFSEEEATSILSRVAQSASKD
                     SKVYIMETLWDRQPYETGSYCLTQISLYFTAMANGNSKMFHSDDLIRCIKNAGLEVEEI
                     HDNIGLGHSILQCRLK"
     CDS             complement(3802..4686)
                     /locus_tag="ctg83_6"
                     /transl_table=11
                     /translation="MPETWKGKTRGGTFGYMFFIYMIRCLGITAAYGFLSLVVLYFIPF
                     APKATASTWQYARNRLKYGRAKAAGLLLKNYYRLGQILIDKVAIGNGMADKYHFEFENY
                     QAFLNVLNGNTGVIMIGAHVGNWEIGAPFFDEYGKKINIVMFDAEHERIKEILEKNAST
                     RDYKIIPVNEDNLTHVFRITEALERKEYVCFQGDRYLNKEKLLSSPFMGKEAEFPMGPF
                     LLASKMRVPVVFYFAMREAKKNYRFHFFIAEAVVHTKEKRAEQALLEQYTQTLEKIVRQ
                     YPEQWFNYYPFWA"
     CDS             complement(4686..4937)
                     /NRPS_PKS="Domain: PP-binding (7-74). E-value: 5.9e-13.
                     Score: 41.1. Matches aSDomain:
                     nrpspksdomains_ctg83_7_PP-binding.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg83_7"
                     /sec_met_domain="PP-binding (E-value: 1.2e-13, bitscore:
                     41.1, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTNEEIIEKIRTTLAEEFEIDVELIQPDAPLMQTLELDSLDLVDM
                     VVLIDRNFGFTVTAKDFAGIKTFQDFYNLVISHIQKED"
     aSDomain        complement(4716..4916)
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg83_7_PP-binding.1"
                     /evalue="5.90E-13"
                     /label="ctg83_7_PP-binding.1"
                     /locus_tag="ctg83_7"
                     /protein_end="74"
                     /protein_start="7"
                     /score="41.1"
                     /tool="antismash"
                     /translation="EKIRTTLAEEFEIDVELIQPDAPLMQTLELDSLDLVDMVVLIDRN
                     FGFTVTAKDFAGIKTFQDFYNL"
     CDS             complement(4959..6188)
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (77-405). E-value:
                     8.2e-50. Score: 161.7. Matches aSDomain:
                     nrpspksdomains_ctg83_8_PKS_KS.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     arylpolyene: APE_KS1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 308.8; E-value:
                     1e-93)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg83_8"
                     /sec_met_domain="APE_KS1 (E-value: 1.8e-167, bitscore:
                     546.6, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRVVITGMGIYSCIGRNQEEVKESLFQGKSGIGIAPARKEMGYF
                     SALTGLVERPDLKKLLDRKKRHSLAEQGEYAYMATLEAFRQARIEEKFLLENEVGILYG
                     NDSSAAPVIQAIDIIREKKNTALVGSGSIFQSMNSTITMNLSVIFHLKGINFTISGACA
                     SGSHAIGMAYLLIKSGLQDCILCGGAQEVNPYSVGSFDGLGAFSAREDEPEKASRPFDK
                     NRDGLVPSGGGASLVLESYESAVKRGATILAEVIGYGFSSNGDHISVPNVDGPRRSLQM
                     AVKDAGIPLEEIAYINAHATSTPVGDLNEAKAIAEVFGSHHPYVTSTKSQTGHEMWMAG
                     ASEVIYSTLMMNNGFIAPNLNFEEPDEASALLNIPSRRVETEFDTFLSNSFGFGGTNSS
                     LIIRKFKENN"
     aSDomain        complement(4974..5957)
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg83_8_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="8.20E-50"
                     /label="ctg83_8_PKS_KS.1"
                     /locus_tag="ctg83_8"
                     /protein_end="405"
                     /protein_start="77"
                     /score="161.7"
                     /tool="antismash"
                     /translation="MATLEAFRQARIEEKFLLENEVGILYGNDSSAAPVIQAIDIIREK
                     KNTALVGSGSIFQSMNSTITMNLSVIFHLKGINFTISGACASGSHAIGMAYLLIKSGLQ
                     DCILCGGAQEVNPYSVGSFDGLGAFSAREDEPEKASRPFDKNRDGLVPSGGGASLVLES
                     YESAVKRGATILAEVIGYGFSSNGDHISVPNVDGPRRSLQMAVKDAGIPLEEIAYINAH
                     ATSTPVGDLNEAKAIAEVFGSHHPYVTSTKSQTGHEMWMAGASEVIYSTLMMNNGFIAP
                     NLNFEEPDEASALLNIPSRRVETEFDTFLSNSFGFGGTNSSLIIRKF"
     CDS             complement(6196..6924)
                     /NRPS_PKS="Domain: PKS_KR (3-170). E-value: 2.4e-18. Score:
                     58.6. Matches aSDomain: nrpspksdomains_ctg83_9_PKS_KR.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     219.1; E-value: 1.1e-66)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg83_9"
                     /sec_met_domain="adh_short (E-value: 2.1e-37, bitscore:
                     118.3, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKYALVTGGSRGIGRAICLKLAEMGYHILINYQSNDTEAEATLQQ
                     IREQGSDGELMKFDVTDAAATHAALNGWIKQHPDTYIEVLVNNAGIRRDNLMLWMEQEE
                     WSRVLDISLNGFFNVTQPLLKNMLVKRFGRIINIVSLSGIKGMPGQTNYSAAKGGIIAA
                     TKALAQEVAKKHVTVNAIAPGFIRTDMTDGIDENEWKKHIPAGRFGEPGEVAALVGFLA
                     SGQASYITGEVISINGGLYT"
     aSDomain        complement(6415..6915)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg83_9_PKS_KR.1"
                     /evalue="2.40E-18"
                     /label="ctg83_9_PKS_KR.1"
                     /locus_tag="ctg83_9"
                     /protein_end="170"
                     /protein_start="3"
                     /score="58.6"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="ALVTGGSRGIGRAICLKLAEMGYHILINYQSNDTEAEATLQQIRE
                     QGSDGELMKFDVTDAAATHAALNGWIKQHPDTYIEVLVNNAGIRRDNLMLWMEQEEWSR
                     VLDISLNGFFNVTQPLLKNMLVKRFGRIINIVSLSGIKGMPGQTNYSAAKGGIIAATKA
                     LAQE"
     CDS_motif       complement(6850..6912)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg83_9_0001"
                     /evalue="2.30E-06"
                     /label="PKSI-KR_m1"
                     /locus_tag="ctg83_9"
                     /protein_end="25"
                     /protein_start="4"
                     /score="20.2"
                     /tool="antismash"
                     /translation="LVTGGSRGIGRAICLKLAEMG"
     CDS             complement(6921..8492)
                     /locus_tag="ctg83_10"
                     /transl_table=11
                     /translation="MQKLYKTAYHTNPMLVENTITLASLYKILFEEEPLTLSDPCMQKL
                     EESFNFLKTFSNDKIIYGINTGFGPMAQYRIEDESLSQLQYNIIRSHATGAGQPLPERY
                     VKAAMIARLYTFLQGKSGVHKELALLITEFINRGIIPYVPEHGSVGASGDLVQLAHIAL
                     TLIGEGEVFYQGTKRDTASVLAENGLQPFQMHIREGLSVTNGTSVMTGIGIVNLIYARQ
                     LMQWAVGASVMMNEIAASYDDFMSEPLNEAKQHEGQQEIARMMRQWVKGSLCVRKRENE
                     LYNGKHEEKIFTHKVQPYYSLRCIPQILGPVYDELLNAEKVLINEINSACDNPIVDPDT
                     QNVYHGGNFHGDYVSFEMDKLKIAVTKLTMLAERQINYLFHDRINGILPPFVNMGVLGL
                     NYGLQASQFTATSTTAECQTLSNPMYVHSIPNNNDNQDIVSMGTNSALMAKTVIENAYQ
                     VMAILMMGIVQAIDCLDIADRISPRSQQVYKEIRAFFPVFREDTPKYKEIESMMVYLKK
                     GRFQEK"
     CDS             complement(8682..10163)
                     /locus_tag="ctg83_11"
                     /transl_table=11
                     /translation="MENKLTIYNTLSRQKELFVPLHAPHVGMYVCGPTVYGDAHLGHAR
                     PAITFDILFRYLTHLGYKVRYVRNITDVGHLEHDADEGEDKIAKKARLEQLEPMEVVQY
                     YLNRYHKAMEALNVLPPSIEPHASGHIIEQIELVEEILKNGYAYESEGSVYFDVAKYNK
                     DHHYGKLSGRNLDDVLNTTRELDGQSEKRNPADFALWKCAQPEHIMRWPSPWSNGFPGW
                     HCECTAMGKKYLGEHFDIHGGGMDLIFPHHECEIAQSVASQGDDMVHYWMHNNMITING
                     QKMGKSYGNFINLDEFFHGTHKLLTQAYSPMTIRFFILQAHYRSTVDFSNEALQAAEKG
                     LERLTEAVKGLERITPSAQTTGIEGVKDLREKCYTAMNDDLNSPIVIAYLFDGARMINT
                     VLDKKATLSAEDLEELKSVFHLFMYEILGIKEEAANNEAREEAYGKVVDMLLEQRMKAK
                     ANKDWATSDKIRDELAALGFEVKDTKDGFTWRLNK"
ORIGIN
        1 caaggcccag accgtcatct ccgaataaag gtgcttcact gtcaatgtcc tccggagtga
       61 tttcttccag attcaatgct tctattaatt caactttcaa tttctcaatc aattcttcca
      121 tattctttat tgtttttcaa tcagtttaaa tactgcttta taggtgtttt tcaataattc
      181 acaccatccg atgatacaat agttcagttt ccctttttgc atgactatac gtgcgtatct
      241 ttccagtttc tccggctgat aggcttcagt tatgaaaaag gtgttttccc cttgtatctt
      301 gtggcggatg caaatctcgc cggacactac attgggtagt gtgtaaacaa atacagccgg
      361 actggctgcc cggtctccgt cctggtctat cagttgctgg tgtctgatat ccgtatgtag
      421 ggatgaagtg gcgttggcaa gtaacatccc catttccagt ggggcgaatg tcttgtcttt
      481 cagtaagtat tcggcggcaa catatcccag tttgcaaagg tcatccattt tatagaattt
      541 catattgttt ccgcctgatt ttttataggt atcacgtata aatatgccga aatccggttc
      601 ttcagaatga aaaataagtt cgttgtttat gaagacagaa ctgttttcaa tacgaacctc
      661 ccgtgtacat cggatttcgg gcaaggtgtt gtcctcatcc ttgaacggag catattccgg
      721 taaagataag acaatggctg cgttacaccc accgaatccc gaagcggttt ttacacaatg
      781 tttcatcgga atgtgttggt gagttgcata gaccggtata ggcataggca cacccggtgt
      841 ttcgtaaccc ggagtgccga acaggatgcc ttgtttcagt tcgtgcatac agacaatgct
      901 ttcaatgatt cccgatgctc ccaaggtatg cccgaaatag ggttttaagc tatgtgtggg
      961 aacttgttcc agatgagcca gcgtgagggc tttggattcc atttcgtcat tgtatacggt
     1021 ggccgtgcca tgggcattga caaagctgat gttttggagg gctgttcctg cctcctgcat
     1081 ggcttggcgg atagcgaaaa agagtccgtc tcctgtacgg gaagggccgg agatatggtt
     1141 ggcgtcatta cttatggctc ctccggaaag aatgatgctg tttggcgtct tttccgtact
     1201 tagtaatacg gctccgcaag cttctcccaa gttcagtccg tcacggttgc tgtcatacgg
     1261 acggcatgga cgggagctga gggaccggaa agacaggaaa ccactggtga tgaaatgaga
     1321 gagaaggtca cctcccgcta caattacttt gcggtagatg ccgttctcta tcatgcgttt
     1381 tcctgttaca agggctgaca ctcctgatat gcaggcgttg gagatgacat gtacccgttc
     1441 ctcagcatgg aaataaccgg caatgttttc tgccattttc caaagaaaga ccgcttcatc
     1501 gggatgttcc gtatgacggg tcagtaagtc gatgttccct ttggtggtag agaggatgag
     1561 tccgcaggtt ttatcctcca aagtttgtcc ggactgacgg atgaggtcgt tgatggtcaa
     1621 tataaacagt tgttccatcc gggtatatgc gcttattcct gctgtttctg cctgttgttg
     1681 caatctctct tgcgagatag tagctgccaa taggggagtg tctgcaatcc gtttgtccgt
     1741 ctgcagggtg atgccactgt ggtaggcccg gatggcttcc aaattttcct gtgtgctgaa
     1801 acccagcgcg ctgatcaggg tatcatgggt gatataggta gtcagatgat gttccatttc
     1861 tttttccact ctatgtaaaa ggcaggatta accaattcca gttctctatt tgtattcagg
     1921 aatacctgtg tagtggttcc tgttgccaca atgttttggt ctgatgcccg gtagatggtg
     1981 tattcaaaaa ggattttggc agcatcacta tgaatatacc gtgtctcgac aatggcttcc
     2041 tcaccgaatg acagcgactg tttgaactgg cagctcaggt ctacgatagg aactacatag
     2101 ccttcccggt agatgctcat atagtccaag ccatatcgct ttccgaaagc ttcacgtcca
     2161 tcttcgaaat aacgcacata ttcaccatgc catactatct gcatggaatc tatttcactg
     2221 aagcggacct tgatggtggt ccggtctgtc agtgctgcct gctgtggact tgtttttcgt
     2281 ttcattcttt tttcagatat attttcatcc ggcattcggc cagaagttca tcgttttctt
     2341 tcacctcggc ggtaatcagt gtgatatcga atatttcctg cacaatggtt attccggtat
     2401 ataattctgc tccggcagaa ggaagacgga atattttcat tttttctaca gagccgataa
     2461 agcctagtgg tacaggctct tctcgcagca tatagatata tcctacccgt gccgctgctg
     2521 attgggcgat gtgttctatg attcctgttt cctgtaatac gccgtcccgg cagaacagat
     2581 tatcgggggt gacggtcagc cctgaccagg atgtattttc ttctatccca tagaaacggt
     2641 ctatcatgac catgggcgga cgttgtggaa tcagccggaa cagttcgtct ccccgacaaa
     2701 tgatttcttt tctgttcatt tcagtctgca ttgcaggata ctgtgtccca gtcctatgtt
     2761 atcatgaatc tcttccactt ccagtccggc atttttaata cagcggatca ggtcatccga
     2821 atggaacatc ttgctgttgc cgttggccat ggctgtgaag taaaggctga tttgagtcag
     2881 gcagtaagag cccgtttcgt atggctgccg gtcccacagc gtttccatga tgtagacttt
     2941 actgtctttg ctggcggact gtgccacacg acttagaata ctggttgctt cctcttccga
     3001 aaagcagtcc agaaactggc tcatccatac ggtgtcaaag cctgaaggaa agggcacggt
     3061 ccgatccagc agattggcgc cgtggccatg gatgcgttct gcaccgggca cgtcggcagt
     3121 ttgttttctc atcatttcca gttgttgagg caaatccaca atggttactt ctacttcttg
     3181 attatattgg acgcatcggg ttgcccatct gccggtgttt ccaccaatat cgagcagtcg
     3241 tttcggtgag tgaagaaata caatttctaa tgcctggctg aacgagttgt ccgagtagaa
     3301 atggtcaaag ccaaaccagc ttttctgtac ctgttccggc agttgggaaa gtccttcgta
     3361 aatggtaggc catccgccga atactttcaa tccttccggc tgaccattta aaagagcctc
     3421 ttccagatag aaaagtcctt gatagttcac atcgtgattg aattccatat tgacacgtgc
     3481 cattttatca ttcagcagaa accagcctgc cttggccagt acatagcggt cttcttccaa
     3541 caggatggtt ccgatggtca gcgatgcttc cagtaatact tgtgctgcat agcgtgtcag
     3601 tccggtctgc acactgattt cttgcagcgt gtatcctttc cgtttgtcgg ccagcaattg
     3661 gaatattccg aatttcaaca tcagacgtga gacttggaat accacgggac cgaaagcgat
     3721 ctcttgcgcc agtctttgtg cctctacagc tgtcaattgc tcttttgtat atcttttatg
     3781 catcataatc cagatttgta tttatgccca gaacgggtag taattgaacc attgttccgg
     3841 atactgccgg acgatttttt ccagcgtttg tgtatattgc tccaataatg cttgttcggc
     3901 ccgcttctct ttggtatgta ccaccgcctc ggcaataaag aaatggaaac gatagttttt
     3961 tttcgcttca cgcatggcaa aatagaatac gacaggtact ctcattttgg aagccagcag
     4021 gaaaggaccc atcggaaatt cggcttcttt tcccatgaac ggactgctga gtaatttctc
     4081 tttattcaga tagcggtcac cttgaaagca gacatattct ttgcgctcca gtgcctctgt
     4141 aatacggaat acatgggtca gattgtcttc atttacggga attattttat aatcgcgtgt
     4201 ggaggcattc ttttccagaa tctcttttat ccgttcgtgt tcggcatcaa acatgacaat
     4261 attgattttt ttgccgtatt catcgaagaa aggagcacct atttcccaat tacctacatg
     4321 ggcacctatc ataattacgc cggtgtttcc attcagtacg ttcaaaaatg cctgatagtt
     4381 ctcgaactcg aaatgatatt tgtctgccat cccattgccg atggctactt tgtcaatcaa
     4441 tatctgcccc agccggtagt aatttttcaa taacagtccg gcggctttgg cacgtccgta
     4501 tttcagtctg ttccgtgcgt attgccaggt actggcggta gctttcggtg cgaaaggtat
     4561 aaaatagagg acgaccaatg acagaaagcc gtaagccgca gtgataccca gacagcgaat
     4621 catgtagatg aagaacatgt atccgaatgt acctcctctt gttttacctt tccatgtttc
     4681 gggcatcagt cttctttttg tatgtgcgaa attaccagat tatagaaatc ctggaaggtt
     4741 ttgataccgg caaagtcttt ggctgtcacg gtgaaaccga aattcctgtc aatcagtact
     4801 accatatcta ccaaatcaag gctatccaat tccaaggttt gcatcaaagg ggcgtccggc
     4861 tgaatcaatt ctacatcaat ctcaaattct tcggccaggg tggttctgat cttttcgatg
     4921 atttcttcgt tggtcataaa tttatatatt ggtttaaatt aattgttttc tttgaatttg
     4981 cggataatca gtgaggaatt ggttcctccg aatccgaatg agttggataa gaatgtgtca
     5041 aattccgttt ctacccttcg ggaagggata ttcagcaggg cagaggcttc atcgggctcc
     5101 tcaaaattga ggttgggtgc gatgaagccg ttgttcatca tcaaagtgga gtaaatgact
     5161 tcactggctc ctgccatcca catctcatgt ccggtctgtg atttggtgga tgtgacgtag
     5221 ggatgatggc tcccgaatac ttccgctatg gcttttgcct cgttcaaatc acctacagga
     5281 gtggatgtgg catgtgcatt gatgtatgca atctcttcca aaggaatacc cgcatccttg
     5341 actgccatct gcaaagagcg tctggggcca tccacattgg gtacggaaat gtgatctccg
     5401 ttggatgaga agccgtatcc tatgacttct gccaggatag tcgctccgcg ctttacggct
     5461 gattcataac tttccagcac cagactggcg cctccgccgc taggtactag tccgtcacgg
     5521 tttttatcga atggacggga tgctttttcc ggttcgtctt cccgggcgga gaaggctccc
     5581 aacccgtcga aactacccac ggaataaggg ttcacttcct gtgctcctcc gcacagaatg
     5641 cagtcctgaa gtcctgactt gataagcaga taagccatgc cgatggcgtg tgaaccactg
     5701 gcacaggctc ccgatatagt gaagttaatt ccttttagat ggaaaataac cgaaagattc
     5761 atggtaatgg tggaattcat ggactggaaa atagaaccgg aaccaaccaa tgccgtattc
     5821 tttttctcgc ggataatatc tattgcttga ataaccggag cagcactact gtcattgcca
     5881 tacagtattc cgacttcgtt ctccaacagg aacttttctt ctatccgggc ttgccggaat
     5941 gcttccaggg tagccatata ggcgtattct ccctgctcgg caaggctatg gcgtttcttg
     6001 cggtccaata atttcttcaa atcgggacgt tcgacaagac cggttaacgc cgagaaatag
     6061 cccatttctt tgcgagccgg agcgattccg atgcctgact ttccttgaaa cagtgactct
     6121 ttcacttcct cttgattcct gcctatgcac gaatagatgc ccattcctgt aataactact
     6181 cttttcatct tttgcttacg tatataatcc tccattgatg gaaatcactt ctccggtaat
     6241 gtaggaagct tgcccggatg ccaggaagcc taccagtgcg gctacttccc cgggctcgcc
     6301 gaagcgtcct gccgggatgt gttttttcca ctcgttctca tcaattccgt ctgtcatatc
     6361 tgtacggata aatcccggtg ctatggcatt taccgtcacg tgttttttgg caacttcctg
     6421 cgccaacgct ttggtagcgg ctatgattcc acctttggct gccgaatagt tggtctgccc
     6481 cggcatccct ttgatgcccg acagggaaac gatattgata atacgtccga atcgctttac
     6541 cagcatattc ttcagcaagg gttgggtgac gttaaagaaa ccgttcagac tgatatccag
     6601 tacccggctc cattcttcct gttccatcca cagcatcaag ttgtcacggc gtataccggc
     6661 attgttcacc agtacctcaa tgtaagtatc gggatgctgt tttatccatc cgttcagtgc
     6721 ggcgtgtgtg gctgctgcat ctgtcacgtc aaatttcatc agttcgccat ccgagccttg
     6781 ttcccgtatt tgttgcaggg tggcttcagc ttccgtatcg ttgctttggt agtttatcag
     6841 tatatgatat cccatttcgg ccagtttcag acaaatggct cgtccgattc cccggcttcc
     6901 tcctgttact aatgcgtatt tcatttttct tgaaacctcc cttttttaag atataccatc
     6961 atgctttcta tctctttata tttaggtgta tcttcccgga aaacagggaa aaatgctcgt
     7021 atttctttat atacttgttg tgaccggggg cttatccggt cggctatatc caggcaatca
     7081 atggcttgta caatacccat catcaggata gccatcacct gataagcatt ttcaatgact
     7141 gtttttgcca tcaaggcgga attggtaccc atgcttacaa tgtcctggtt gtcattgttg
     7201 ttggggatgc tatgcacata catcggattg gacaaagtct gacattctgc cgtggtagag
     7261 gtggctgtga actgggaggc ctgcaaacca taattcagcc ccagtactcc catattgaca
     7321 aaggggggga gaatgccgtt gatgcggtcg tgaaacaggt aattaatctg ccgttcggca
     7381 agcatcgtca gtttggtgac tgctattttc aacttgtcca tttcaaaaga tacataatct
     7441 ccgtggaagt taccaccatg atatacattc tgtgtgtcag ggtccactat cgggttgtca
     7501 caagctgaat ttatttcgtt tatcaatact ttttcagcat tgagtaattc atcataaacc
     7561 ggccctagaa tttgtggaat gcaacgtagc gaataatagg gctgcacttt atgggtgaag
     7621 atcttctctt cgtgcttccc attataaagt tcattctctc ttttgcgtac acacaggctg
     7681 ccttttaccc attggcgcat catgcgggct atctcttgtt gtccttcatg ctgtttggct
     7741 tcattcagcg gttcagacat gaagtcatcg tatgaggcgg ctatttcatt catcataaca
     7801 gatgcaccta ccgcccattg cataagttgg cgtgcgtaaa tcagattgac aatacctata
     7861 cctgtcatga ctgaagtgcc gttggtcact gaaagccctt cgcggatgtg catttgaaaa
     7921 ggttgcaatc cgttttccgc cagcacagag gccgtatctc ttttcgtgcc ttggtaaaag
     7981 acttctcctt ctccaatcag agtgagggcg atatgggcga gttgtaccag atcaccactg
     8041 gcccccacac tgccgtgttc gggtacgtat ggaataatcc cccggttgat aaactcggta
     8101 atgagcaacg ccagttcttt atgtacgccg gattttcctt gcagaaaagt atagagacgc
     8161 gctatcatgg cagctttgac atagcgttcc ggaagaggtt gcccggctcc ggtagcatgg
     8221 ctgcggatga tgttgtattg taattgcgat aaggattcat cttcaatacg atattgggcc
     8281 atggggccaa agccggtatt gatgccatag atgattttgt cgttggagaa tgttttcagg
     8341 aaattgaaac tctcttccag tttttgcata catgggtcgg agagtgtcag tggctcttct
     8401 tcaaacaaaa tcttatatag ggacgctaaa gttattgtat tctcaactag cattggattg
     8461 gtgtgataag cagttttgta tagtttctgc aaaaatagtt atttaaaaat aagtattacc
     8521 atccgaaagg agatttttca gttttgatgg ttatctgaaa ggttcaccac agattataca
     8581 aataaacgca gatgcttctt aaatcattga ttgttaggtt ggataatctg tgtgaatctg
     8641 tatagtctgt ggtgaaaaaa tatagtaccg ctctacgtat tctatttatt cagtctccat
     8701 gtgaaaccat ctttggtatc tttcacttca aagccaagag cggctagctc atcacggatt
     8761 ttatcacttg tagcccagtc tttattggct ttggctttca tacgttgttc cagcagcata
     8821 tctactactt tgccatatgc ctcttcacgt gcctcgttat tggcggcttc ttcttttata
     8881 cccaagattt catacataaa gagatggaac acacttttca gctcttccag atcttcggcg
     8941 gaaagggtcg cttttttatc aagcactgtg ttgatcatac gggcgccgtc aaacagatag
     9001 gcgatgacaa tcggtgagtt caggtcatcg ttcatggctg tatagcattt ttcacgtaag
     9061 tcttttacgc cttctatgcc ggtggtttgt gcgcttgggg tgatgcgttc aagacctttt
     9121 acagcttctg tcagtcgttc caatcctttt tcggctgctt gtaatgcttc gttactgaag
     9181 tccactgtac tgcggtaatg tgcttgaagg atgaagaaac ggatggtcat ggggctgtag
     9241 gcttgtgtca gtaacttgtg agtaccgtga aagaactcat ccaagttaat aaagttgccg
     9301 tatgattttc ccatcttctg cccattaatg gtaatcatgt tgttgtgcat ccaatagtga
     9361 accatgtcat ctccttgtga agccacgctt tgtgcgatct cacattcgtg gtgtgggaaa
     9421 attaagtcca ttccccctcc atgaatatcg aaatgctcgc ccaaatattt tttgcccatt
     9481 gcggtacatt cacaatgcca accgggaaaa ccgttactcc acgggcttgg ccagcgcatg
     9541 atatgttcgg gttgtgcaca tttccacaga gcgaaatcgg caggattacg cttctcgctt
     9601 tgaccgtcca gttcgcgggt ggtgttcagc acatcgtcca ggttacggcc ggacagtttg
     9661 ccgtaatgat ggtctttgtt gtattttgct acatcgaaat aaacggaacc ttcactttca
     9721 taagcatagc cgtttttcag aatttcttct accagttcta tctgttcaat gatatggcct
     9781 gatgcatgtg gctcgatact gggtggaagt acattcaagg cttccattgc cttgtggtag
     9841 cgattgaggt aatattgcac tacttccatg ggttccagtt gctccagacg ggcctttttg
     9901 gcgattttat cttcgccttc atctgcatcg tgttccagat gaccgacatc ggtaatgtta
     9961 cggacataac gtaccttgta tcccagatgg gtaagataac ggaacaggat atcgaacgtg
    10021 atggcgggac gtgcgtgtcc taaatgggcg tcgccatata cggtaggacc gcatacatac
    10081 atacctacat gaggggcatg caagggaacg aaaagttcct tttgacggct taatgtattg
    10141 taaatggtta gtttattttc cataattcat tctattagaa ttgcaaagtt ataaattaaa
    10201 gtgtgtattt ggctaataat taacaaaaaa tctgatgctg
//
