LOCUS       c00004_gnlPro..        11700 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|KCDNGBBH_4.
ACCESSION   c00004_gnlPro..
VERSION     c00004_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 00:29:23
            Original ID  :: gnl|Prokka|KCDNGBBH_4
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 11700
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..11700
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1185:7173]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1186..7173
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..11700
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..11700
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             complement(3..1058)
                     /locus_tag="ctg4_1"
                     /transl_table=11
                     /translation="MNNRLSLLLIGCIFPFLSFYAQKNMNLPPYYPTVKGITDYAVWQL
                     VYPDSLLRANIAGEAVCTLRIDSLGTVRCKYIEATHPLFAKAAEDVIEGMREWQPAKKA
                     GRDIDTTIVFHIPFNPDVYSDRIWRQQQVLESCRGQLVDSMPVFPDDIRSLVMGNMSWP
                     DDKVDKAVAICRFTVNEKGEIVDIRVIKGTHPAFDKESIRILSNFPRLIPAMKNRKSVP
                     YDYFLTMRFWKEDLEHYLLYRECAQEDLEKITWEPYRYSSYPGGTVALTQFINSHLKIT
                     PEMKATGKQGRVIYSFNVDIDGSMKDFQLVRGLDPLMDAEALRVLQLVNERWSTGYYFN
                     SKKWYREFYVNQ"
     CDS             complement(1186..2229)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg4_2"
                     /sec_met_domain="IlvN (E-value: 1.1e-46, bitscore: 148.0,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 1.3e-41, bitscore: 131.9,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQLNFGGVTETVVIRDEFPLEKAREVLKDETIAVIGYGVQGPGQ
                     SLNLRDNGFNVIVGQRPGKTYEKAVADGWVPGETLFGIEEACQKATIVMCLLSDAAVMS
                     VWPTIKPYLTQGKALYFSHGFAITWSDRTGVVPPTDIDVIMVAPKGSGTSLRTMFLEGR
                     GLNSSYAIYQDVTGKAYERTIALGIGIGSGYLFETTFQREATSDLTGERGSLMGAIQGL
                     LLAQYEVLRENGHSPSEAFNETVEELTQSLMPLFAKNGMDWMYANCSTTAQRGALDWMT
                     PFHDAIKPVVEKLYHSVKTGNEAQISIDSNSKPDYREKLEEELKALRESEMWQTAVTVR
                     KLRPENN"
     CDS             complement(2264..3007)
                     /locus_tag="ctg4_3"
                     /transl_table=11
                     /translation="MMSENKVGTYRFVAEPFHCDFSGKLTMSVLGNHLLNCAGFHAADR
                     GFGIATLNENHYTWVLSRLAVELENMPCQYEGFSIQTWVENVYRLFTDRNFAILDKEGK
                     TVGYARSVWAMISMETRKPADLLTLHGGSIIDYVCDKKCPISKPGRIKVTEKAPVSEYQ
                     TRYSDIDINGHVNSIKYIEHILDLFPIEFFKEKRIKRFEMAYVAESYYGDILSFYREEV
                     EEKEYDIEVKKNGTDVVVRSKVIFI"
     CDS             complement(3007..3561)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg4_4"
                     /sec_met_domain="ALS_ss_C (E-value: 1.3e-19, bitscore:
                     59.8, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKTLYTLIVHSENIAGLLNQITAVFTRRQINIESLNVSASSIKG
                     VHKYTITAWTTQDVIEKVVKQIEKKIDVLQAHYFTDSEIYQHEIALYKVSTPEFQENPM
                     ASKVIRRYSARIVEVNPVFSIVEKNGMSEEITALYEELRGLGCVLQFVRSGRVAITTSC
                     FERVNEYLTQREEKYRQQKTE"
     CDS             complement(3572..5269)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg4_5"
                     /sec_met_domain="TPP_enzyme_C (E-value: 2.6e-49, bitscore:
                     156.5, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAKEKITGAEAMMRSLEYQGVKTLFGYPGGSIMPTFDALYHHRNT
                     LNHILVRHEQGAAHAAQGFARVSGEVGVCLVTSGPGATNTITGIADAMIDSTPIVVIAG
                     QVGASFLGTDAFQEVDLVGITQPITKWSYQIRRAEDVAWAVARAFYIAKSGRPGPVVLD
                     FAKNAQVEMVDYEPMKLDFIRSYDPEPNPDKESLQEAAELINNAQRPLVLVGQGVELGN
                     AQDELRAFIEKADMPCGCTLLGLSAIPTSHPLNKGMLGMHGNLGPNVKTNECDVLIAVG
                     MRFDDRVTGKLDTYAKQAKVIHLDIDHSEIDKNVKVDVPVLGNCKYTLAMLTQLIRKNE
                     HSEWIDSFTEYEKTEYEHVISKEIHPVDGALNMGEVVRAVSEASNNEAVLVTDVGQNQM
                     MAARYFKYSKNRSIVTSGGLGTMGFGLPAAIGATFGRPDRTVCVFMGDGGLQMNIQELG
                     TIMEQKAPVKIILLNNNYLGNVRQWQAMFFGHRYSFTPMLNPDYMKIAEAYEIPARRVM
                     KREELQAAIHEMLTTDGPFLLEACVIEEGNVLPMTPPGGSVNQMLLEC"
     CDS             complement(5371..7173)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ILVD_EDD"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg4_6"
                     /sec_met_domain="ILVD_EDD (E-value: 1e-216, bitscore:
                     709.9, seeds: 918, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNQLRSSFSTQGRRMAGARALWGANGMKKEMMGKPIIAIVNSFT
                     QFVPGHTHLHEIGQQVKVEIEKLGCFAAEFNTIAIDDGIAMGHDGMLYSLPSRDIIADS
                     VEYMVNAHKADAMVCISNCDKITPGMLMAAMRLNIPAVFVSGGPMEAGEWNNQHLDLID
                     AMIKSADASVSDEDVAQIENNACPGCGCCSGMFTANSMNCLNEAIGLGLPGNGTILATH
                     ANRTQLFKDAAALIVKNAYKYYEEGDDSVLPCNIATRDAFLNAMTLDIAMGGSTNTVLH
                     LLAIAHEAEVDFKMDDIDMLSRHVPCLCKVAPNTQKYHIQDVNRAGGILNILGELSKGG
                     LLKTDVKRVDGLTLAEAVEKYNICKKEVDTEAKRIYSSAPGNKFNIKLGSQNAVYKELD
                     TDRANGCIRDLQHAYSKDGGLAVLKGNIAQDGCVVKTAGVDESIWKFSGPAKVFDSQDA
                     ACEGILGGKVVSGDVVVITHEGPKGGPGMQEMLYPTSYIKSKHLGKECALITDGRFSGG
                     TSGLSIGHISPEAAAGGNIGKIVDGDIIEIDIPNRSINVKLSDEELAARPMTAVTRDRK
                     VPKSLKAYASMVSSADKGGVRIID"
     CDS             complement(7584..7958)
                     /locus_tag="ctg4_7"
                     /transl_table=11
                     /translation="MKRLVLLVVVALGMSATSFAGEKVEGKDWKVDVNVAKLSKYLNLD
                     ARQMEEVANISDYFADKVQSASYAKEAKQGKKLREAVYGNFKLMKRTLTNEQYKKYVQL
                     LNVTLKNKGLDSYMEDVANK"
     CDS             8314..8880
                     /locus_tag="ctg4_8"
                     /transl_table=11
                     /translation="MENKYITVAYKLYVMQDGQKTLVEEATVEHPFQFISGLGTTLERF
                     ETEITALKKGDKFKFVIPTAEAYGEYMPEGVRTVSKDMFTIDGVFDEERIFPGAVIPLQ
                     DNEGHHFYATVSEVTNDTVTVDLNHPHAGKDLTFEGEVVESRTATNEEIQEMVKMMSGE
                     GCGCGCGDCGEGCGDEGGCGCGHCH"
     CDS             9233..10576
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Radical_SAM"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg4_9"
                     /sec_met_domain="Radical_SAM (E-value: 9e-11, bitscore:
                     32.0, seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNRENAKPFAHSKHYLYFWQKYSDQMNENVLAKLKILAESAKYDV
                     SCSSSGTVRRNQSGALGNTVGGWGICHSFAEDGRCISLLKIMLTNYCIYDCAYCINRRS
                     NDIPRATLSVSELVDLTIEFYRRNYIEGLFLSSGVVRNPDYTMERLVRVAKDLRLVHKF
                     NGYIHLKSIPGASRELVNEAGLYADRLSVNIEIPKEENLKLLAPEKDHKSVYQPMRYIQ
                     QGILTNKEDRKKFRHVPRFVPAGQSTQMIVGATTESDKDILYLSSSLYQHPTMRRVYYS
                     GYISVNTYDKRLPALKQPPLVRENRLYQADWLLRFYQFKVEEIVDDSYPDLDLEIDPKL
                     GWALRHPEQFPIDINQADYEMILRVPGIGIKSARQIIASRRFSKLGFYELKKIGVVMKK
                     AQYFITCNELPTRTVNELTPTGVRRLLVPKPKKKVDERQLILNFTDNE"
     CDS             10573..11340
                     /locus_tag="ctg4_10"
                     /transl_table=11
                     /translation="MILFIYDHTFEGLLTCIFDAYFRKTFPDLLLMEGEPLPLFYNEAI
                     HIATDEEKAGRVWRGLQKKISKHALFSLTCCWLSELPKVDEMLFHYIQKAINSPHSIET
                     NFADPDVLELAKIYKRVDGERVHLMQFVRFQKAADGTFFAAVKPQFNALPLAVDHFKDR
                     FADQRWLIYDVKRQYGYYYNLTEMEEVTFEDPRQAHLVTGMLNETLMDNNERLFQELWK
                     TYFKSICIKERWNPQKHRQDMPVRYWKYLTEKQ"
     CDS             complement(11306..11698)
                     /locus_tag="ctg4_11"
                     /transl_table=11
                     /translation="LFNSLDFEKMNEAARVLFDYTDFTSFSKLHTDVKTNNCRIMYAEW
                     TRVSGTEWVFTIKADRFLRNMVRAVVGTLVEVGRGKMTLDGFRKVIENKDRCSAGSSVP
                     GHALFLVDVGYPEELFIVSPSDISNT"
ORIGIN
        1 aattgattca cataaaactc ccgataccat ttctttgaat tgaaataata ccccgtactc
       61 catctttcat tcactaattg aagtacccgc aatgcttcgg catccattaa tggatcaagt
      121 cctctcacca actgaaaatc tttcattgaa ccatctatat ccacattgaa actataaatc
      181 acccgtccct gctttcccgt agccttcatt tcgggagtaa ttttcagatg agaattaata
      241 aattgcgtca aagcaacagt accaccggga taagaagagt atctataagg ctcccaagtg
      301 atcttttcca aatcttcctg tgcgcattcc ctatataata aataatgctc cagatcctct
      361 ttccaaaaac gcatagttaa aaaataatca tatggcacag attttctgtt tttcatagca
      421 ggaatcaacc ggggaaaatt agaaagaata cgtatggact ctttatcaaa agccggatga
      481 gtacctttta tcacacggat atccacaatt tctccttttt catttaccgt aaaacggcaa
      541 atagcgacgg ctttatccac tttatcgtca ggccaactca tatttcccat aacaagacta
      601 cgaatatcat caggaaagac aggcatggaa tcgacaagtt gtcctctgca agattccaga
      661 acttgctgct gccgccaaat gcggtcactg taaacatcag gattaaaagg aatatgaaag
      721 acgatagtag tatctatatc tctacccgct ttctttgcag gctgccattc acgcataccc
      781 tcaatcacat cttcggccgc cttagcaaac aaggggtgag tggcttcaat atatttacaa
      841 cggacagtcc ccaaactatc aatgcggagc gtacacacag cttcacctgc aatattggcc
      901 cttaataaag aatccggata tacgagctgc cacacagcat aatccgtaat accttttact
      961 gtaggataat atggcgggag attcatgttc ttttgtgcat aaaaagatag aaagggaaat
     1021 atgcacccta ttaataaaag tgataatcta ttattcatgc ctaagtcaag ttttcacaaa
     1081 attagcgact acacatgata taaacaacac cactaacatt aatatatata aaagaaagcg
     1141 gagatacctc atcgcatccc cgctttctac attaaatact aactattaat tattttcagg
     1201 acgaagttta cgtacggtta cagcagtctg ccacatttcg ctttcacgca atgccttcaa
     1261 ttcttcttcc aatttttcac gataatcggg tttagagtta gaatcgatag aaatctgagc
     1321 ctcgttgcca gtcttcacac tgtgatataa cttttcaact acaggtttga tagcatcatg
     1381 aaacggagtc atccaatcca atgcaccgcg ctgagcagta gtagagcagt tagcatacat
     1441 ccagtccata ccattcttag caaacaaagg catcaatgac tgggttaatt cttctacagt
     1501 ttcattaaat gcttcagaag gactatgtcc gttttcacgc aatacttcat actgagccaa
     1561 caacaatcct tggatagccc ccattaaaga accgcgttca cctgtcaggt cagaagttgc
     1621 ttcacgctgg aaagtcgttt cgaataaata gcctgaaccg ataccaatac ccaatgcaat
     1681 agtacgttca taagccttac cggttacatc ctgatagata gcgtatgaag agttcaagcc
     1741 acgaccttcc aagaacatgg tacgcagtga agtacccgaa cctttaggag ctaccatgat
     1801 cacatcaata tcagtaggag gaactacccc tgtacggtca ctccaagtaa tggcaaagcc
     1861 atgagagaaa taaagtgcct tgccttgggt caagtaaggt ttgatagtcg gccatacaga
     1921 cataacagct gcatcagata acagacacat tacgatagtc gctttctgac aagcctcttc
     1981 aataccaaac agagtttcac ccggaaccca tccgtcagca actgcttttt catatgtttt
     2041 tcccggacgc tgaccaacaa ttacattgaa accattgtcc cggagattca aagactgccc
     2101 cggtccctgt acaccatacc cgatcacagc gattgtttca tctttcaata cttcacgtgc
     2161 tttttccaaa ggaaattcat cgcggataac tacagtttct gtaacgccgc caaaattcaa
     2221 ttgtgccatt ttaaattata aattaaaaat taaaaattag attctaaata aatatcacct
     2281 tactacgaac gacaacatct gtgccattct tcttcacctc tatatcatat tctttctcct
     2341 ccacttcctc gcggtagaaa ctcaatatat caccataata actctcagct acataagcca
     2401 tctcaaaacg tttaatccgt ttctctttaa aaaactctat aggaaacaaa tcgagaatat
     2461 gttctatata cttaatactg ttcacatgac cattaatatc aatatcgcta tatctggtct
     2521 ggtattcaga aaccggagct ttctctgtca ccttaatacg accgggcttg cttataggac
     2581 atttcttatc gcatacataa tcaatgatac tacctccgtg aagcgtaagc aggtcagcag
     2641 gtttgcgagt ttccatactg atcatcgccc atacagaacg ggcgtatccg acagtctttc
     2701 cttccttgtc caaaattgca aaattacggt ctgtaaaaag acgataaaca ttctctaccc
     2761 atgtctgaat actgaaaccc tcatattgac agggcatatt ctctaactct acagctaaac
     2821 gggaaagtac ccatgtataa tgattctcat tgagcgtagc aattccgaaa ccccggtcgg
     2881 cagcatgaaa gccggcacaa ttcagtaaat gattacccaa cacactcatg gtcaactttc
     2941 cactgaaatc acagtgaaag ggttctgcca caaatctgta tgttcctact ttattctcac
     3001 tcatcattat tctgtttttt gctggcgata cttttcctcg cgttgggtca gatattcgtt
     3061 cacacgctcg aaacagctgg tagtaatggc cacacgtccc gaacggacaa actgcaacac
     3121 acatcccaat ccgcgcaact cctcataaag agcagtaatt tcctcactca tcccattctt
     3181 ttcaacaata gagaaaaccg gattcacttc tacaatgcgg gcactataac ggcggataac
     3241 tttagatgcc ataggattct cctgaaattc aggagtagaa accttgtaca aagcaatctc
     3301 atgctgataa atctcactat cagtaaaata atgtgcctgc aaaacatcta ttttcttttc
     3361 aatctgcttc accacttttt ctatcacatc ctgggtggtc caagcagtaa tagtatattt
     3421 atgcaccccc ttgatggaag atgcagaaac attaagactt tcgatattaa tttggcggcg
     3481 agtaaacact gccgtaatct ggttcagcaa accggcgata ttttctgaat gaacgattaa
     3541 tgtatataat gtcttgtcca taattattaa attagcattc cagtaacatc tgattcaccg
     3601 agcctcccgg aggtgtcatc ggcaacacat ttccctcttc tatcacacaa gcttccagca
     3661 ggaatggccc gtcagtagtc aacatttcat ggatagcagc ctgcaattcc tcacgcttca
     3721 taacacggcg ggcaggaatc tcatatgcct cggcaatctt catataatcc ggattcaaca
     3781 tcggagtaaa tgaataacga tgaccaaaaa acatagcttg ccattgacga acattaccca
     3841 aatagttatt gttcaataaa ataatcttta ccggtgcttt ttgctccatg atagttccca
     3901 attcttgaat attcatctgc aaaccgccat cccccataaa tacgcataca gtacgatccg
     3961 ggcgaccgaa agtagcgcct atagcagcgg gaagaccgaa tcccatcgtt cctaatccac
     4021 ccgaagttac aatgctacgg ttcttactgt atttaaaata acgagcagcc atcatttggt
     4081 tctgtcctac atctgtcacc aatacagcct cgttgttcga agcctcactt accgcacgca
     4141 ccacttcacc catattcaac gccccgtcaa caggatgaat ttctttactg ataacatgtt
     4201 catattccgt cttttcatat tcagtaaagc tatcaatcca ttcggaatgt tcattcttcc
     4261 ggataagttg cgtcagcata gctagcgtat atttacaatt acctaatacg ggtacatcca
     4321 cttttacatt cttatctatt tcagaatggt caatatccaa atgaatcacc tttgcctgtt
     4381 tagcatatgt atctaatttt ccagttacac gatcgtcaaa gcgcatacct acagcaatca
     4441 acacatcaca ttcattagtt ttgacattgg gccccagatt tccatgcata cctaacattc
     4501 ctttatttaa aggatgcgaa gtcggtatag ccgaaagtcc cagcaaagta cagccacaag
     4561 gcatatcggc tttttctata aatgcacgta actcatcttg cgcattacct aactctaccc
     4621 cctgtcctac caacactaat ggcctttgag cattgtttat caattcggca gcctcctgaa
     4681 gagattcctt atcaggatta ggttctggat cataactacg gataaaatca agcttcatcg
     4741 gttcataatc caccatctcc acttgtgcat tcttggcaaa gtccaaaacg acaggaccgg
     4801 gacgtccgct tttagctata tagaaagcac gggctacagc ccaagctaca tcttccgcac
     4861 gacgaatttg gtaactccat ttggtaatag gctgagtgat gcccaccaga tccacttcct
     4921 gaaaagcatc cgtacctaaa aaggaagctc ctacctgccc ggcaatcacc acgataggcg
     4981 tgctgtcaat catagcatcg gcaatgccag taatggtatt tgtcgcaccg ggcccgctag
     5041 tcaccaaaca gacaccaacc tcaccggata cgcgggcaaa tccctgtgct gcatgggcag
     5101 ctccttgttc atgacggacc aatatatggt tcaatgtatt tctatgatga tataaagcat
     5161 caaaagtagg catgatagaa cctccgggat atccgaaaag agttttcact ccttgatact
     5221 ccaaagaacg catcatcgcc tctgctcctg ttatcttttc ttttgccata attgtttagt
     5281 tgagaattga gaatcaaaaa aatacgatgc cggacaatcg accaatgaca acaaatctat
     5341 tttttttatt ctcaattttt aatttctaat ttagtcaatg attctcactc ctcctttatc
     5401 tgcagaactt accatactag cgtatgcctt caagctttta ggaactttac ggtcacgggt
     5461 caccgctgtc atcggtcggg cggccaattc ttcgtcactc agtttcacat tgatactgcg
     5521 attcggaata tcgatttcaa ttatatcacc atccactatt tttccgatat taccacccgc
     5581 tgcagcttcg ggagaaatat gcccgatgct taatcccgaa gttcctccac taaaacgtcc
     5641 gtcggtaatc aaagcacatt cttttcctaa atgcttggat ttgatatagg aagtaggata
     5701 aagcatttcc tgcataccgg gaccaccttt cggaccttca tgagtgataa caacaacatc
     5761 tccgctgact acttttcctc ctaaaatacc ttcacaagca gcatcctgcg aatcaaacac
     5821 cttggcaggc cccgagaatt tccaaatact ttcatccact ccggccgttt tcactacgca
     5881 accatcctgt gcaatgttcc ctttcaaaac ggccaaaccc ccatctttac tataggcatg
     5941 ttgcaaatcg cggatacaac cattggcacg atctgtatcc agttctttat aaacagcatt
     6001 ctgagaacct aactttatat tgaatttgtt tcccggagca cttgaataaa tacgttttgc
     6061 ttcagtatcc acttctttct tacatatatt atatttttcg acagcttccg ccaatgtcag
     6121 gccgtccact cgtttcacat cagttttcag caaaccaccc ttggataatt ctcccaatat
     6181 attaaggata ccaccggcac ggttcacatc ctggatatga tatttctgtg tattcggagc
     6241 tactttacac aaacaaggca catggcgtga aagcatatca atatcatcca tcttgaaatc
     6301 tacttccgcc tcgtgggcga tagctaaaag atggagcaca gtattggtag aaccacccat
     6361 tgcaatatcc aatgtcatgg cattcagaaa agcgtcacga gtagcaatgt tgcatggtaa
     6421 cacgctgtca tctccctcct cataatattt ataagcattc ttcactatca gagcagccgc
     6481 atctttaaac aactgagtac ggttggcatg agtcgccaaa atagtgccat tccccggaag
     6541 ccccagacca atagcctcat tgaggcaatt catggaatta gccgtaaaca tacccgaaca
     6601 gcaaccacag ccaggacacg cattattttc aatttgagcc acatcctcat cgctgaccga
     6661 tgcatcagca gatttaatca tggcgtctat caaatcaaga tgctggttat tccattctcc
     6721 cgcttccata ggaccacccg atacaaaaac agccggtatg ttcagtcgca tggcagccat
     6781 cagcatacct ggagtgattt tgtcacaatt actgatacac accattgcat ccgccttgtg
     6841 agcattcacc atatattcca cgctgtcggc aatgatatca cgactgggca gtgaatacag
     6901 cataccatcg tgtcccatag ctattccgtc atcaatggca atcgtattga attctgctgc
     6961 aaaacatccc aatttttcaa tctcaacttt cacctgctga cctatttcat gcagatgggt
     7021 atgtcccgga acaaactgtg taaacgaatt tactatggct ataatgggct tgcccatcat
     7081 ttcttttttc atgccgttag ccccccataa agctctcgct cctgccatac ggcgaccctg
     7141 tgtgctaaac gaactgcgta actgattctt catcttattc taaatctata acgtcctata
     7201 cttattgaaa aagccttcct caccatgtga gaaaggcttc caattatttc tttatatgta
     7261 caactacaca tacacaacct ttctcacgct cctagtgtga ccaccacgac gcgaataata
     7321 tgcaggactg ctaggttatt tagagtagta atattcatat atctgttttc tttgtttctt
     7381 taacgactgc aaaggtaagg cgtttttcgt aacaaacaaa taaaatgaag attttttttc
     7441 ttataaatta ttattcgtaa ctaaatcgag ctttaaacaa tcattttatc acaaatatac
     7501 actgtatctt ccaacggata aataaaaaag agaatgcatt ggtttgcatt ctcttttcag
     7561 ttcatttatt tcattttata aatttactta ttcgccacat cttccatata ggaatccaac
     7621 cccttgtttt tcaatgtaac attcaacaac tgtacatact tcttgtactg ctcatttgtc
     7681 aatgtacgtt tcatcagttt gaagtttcca tatacggctt cacgcaattt tttaccttgt
     7741 ttagcttctt ttgcgtagct tgcgctttgt actttgtcag caaaataatc agaaatatta
     7801 gcaacttcct ccatctgacg tgcatccaaa ttcaaatatt tgctcaactt tgcgacgtta
     7861 acatctacct tccaatcttt accttctact ttttctcctg caaaacttgt agctgacatt
     7921 cctaatgcca ctacaaccaa caatactaaa cgtttcataa tacctaaaat tttaatttgt
     7981 taaacctaaa aacaatttat ttagtaccta agaactaaat aatacctttt aaaaacaatc
     8041 tcgttatctc tttctcttta cactgcaaat ataacaacat gctttacgac atgttgtcat
     8101 atatccgtta attaaagcaa aaatctatca aggcgagcgg ttaattgatt tatatcaagg
     8161 atcaaacgca atcaaaagcg catttatagt atcataataa caaatttatg taatataaac
     8221 gtaataacaa aggattaagg ggaattaatt cgtatctttg ccaacaaaaa acttacgtaa
     8281 atagtttata ttacattatt ataataagaa aacatggaaa ataagtacat caccgtagca
     8341 tacaaacttt atgtaatgca ggacggccag aaaacattgg tagaagaagc aactgtagaa
     8401 catcctttcc aattcatatc cggattagga accacactgg aacgctttga aacagaaata
     8461 acagccttaa agaagggtga caaatttaaa tttgtcattc ctaccgcaga agcctacgga
     8521 gaatatatgc ccgaaggtgt gcgcactgta tctaaagata tgttcaccat tgatggtgtt
     8581 tttgatgaag aacgcatctt cccgggagct gtcattccct tacaggacaa tgagggacat
     8641 cacttctacg ctaccgtaag cgaagtaacc aatgacactg taactgtaga tttgaaccat
     8701 cctcatgcag gtaaagatct cacttttgaa ggtgaagtag tagaatcccg cacagccact
     8761 aatgaagaaa ttcaggaaat ggtaaaaatg atgagtggag aaggatgcgg ctgtggttgt
     8821 ggtgactgcg gagaaggatg cggtgatgaa ggtggatgcg gatgcggaca ttgtcattaa
     8881 tttcgttaaa caatagataa agaagaggac ggaacaaaac atccgccctc tttttattat
     8941 tgataacgaa acaatactga ttggcagctt cagtgtttct tcaaacattt caaaaaaaag
     9001 aacttgaagt tttcaaaaaa gatctagttc ttttctatta aacatctagt tcttttaaaa
     9061 aaagaactag acctttttta aaaacgtccg gttctttttg actataggac cggttatctt
     9121 gattcatagg cgaaacaaat gcatttagct gggtaataaa cacatttttc ttctattgca
     9181 agacacagat aataagacta aagaataaca taatgtaaca aagaagttaa aaatgaacag
     9241 agagaatgcc aaaccgtttg cccattccaa acactatctg tatttttggc agaaatattc
     9301 tgatcaaatg aatgagaatg tccttgccaa attgaaaata ctcgcagaat ctgctaaata
     9361 tgatgtttcc tgctctagta gtgggaccgt gcgccgtaac caatccggcg cattgggaaa
     9421 caccgtaggc ggctggggga tatgccatag cttcgccgag gacggtcgtt gcatatcctt
     9481 gctgaaaata atgctgacca attattgtat ctatgactgt gcctattgta tcaatagaag
     9541 aagcaatgac attccccgcg ccacgctttc ggtaagcgaa ctggtagacc tcaccatcga
     9601 attctaccga cgcaactata tagaagggct tttcctcagt tccggcgttg tacgcaatcc
     9661 tgattacacc atggaaaggt tggtacgtgt tgccaaagac ctgcggttag tacacaaatt
     9721 caacggatat attcacctga aaagtatccc cggagccagt cgcgaactag tcaatgaagc
     9781 cggactctac gccgaccgtc tcagtgtaaa catagaaatt cccaaagaag agaatctgaa
     9841 attactggct cccgaaaaag atcacaaaag tgtataccag cccatgcgct atatccagca
     9901 gggaatactt accaacaaag aagaccgaaa aaaattccgc catgttccac gcttcgttcc
     9961 tgccggacaa agtacgcaga tgattgtcgg tgccacaacc gaatcagaca aagacatcct
    10021 ttatctttct tcttcactct accaacaccc caccatgagg cgcgtctact actctggata
    10081 tatatccgta aatacatacg acaaacggct tccggcactg aaacagccgc cattggtacg
    10141 tgagaaccgt ttgtatcaag ccgactggct gttacgtttc tatcaattta aagtagaaga
    10201 aatagtcgat gactcctatc ctgatctaga tttggaaatc gaccccaaat taggttgggc
    10261 attacggcat ccagaacaat ttcctataga tataaaccag gcagattacg aaatgattct
    10321 cagagtaccg ggtatcggaa tcaaatcggc aagacaaatc atcgcgtcac gccgcttctc
    10381 aaaactggga ttctatgaac tgaaaaaaat aggtgtagtg atgaaaaaag cgcaatactt
    10441 cataacctgc aacgaactcc ccacccggac tgttaatgaa ctaactccga caggagtacg
    10501 cagactgtta gtacccaaac ccaaaaagaa agtggacgaa cgccaattaa tactaaactt
    10561 tactgataac gaatgattct gtttatctat gaccatacat ttgaaggctt gctgacttgc
    10621 attttcgatg cttacttccg caaaaccttt cctgacttgc tcttgatgga aggcgagccg
    10681 ctacccttgt tttacaatga agccatacac atagccactg atgaagagaa agccggacgc
    10741 gtgtggcgcg gattacagaa aaaaatctcc aagcatgccc ttttcagctt gacctgctgc
    10801 tggttatcag aattaccaaa ggtggacgaa atgcttttcc actatatcca gaaggccata
    10861 aactctcctc attctattga gaccaacttt gccgatcctg atgtgctgga gcttgcgaaa
    10921 atctataaaa gagtagatgg agaacgagta cacctcatgc agttcgtccg tttccaaaaa
    10981 gcagcggacg gaactttctt tgcagccgta aaacctcaat tcaacgcact gccactggct
    11041 gtggatcatt tcaaagaccg ttttgccgac cagcgttggc tcatttatga tgtgaagcga
    11101 caatatgggt attactataa tctaacagag atggaagaag taacatttga agatccccgc
    11161 caagcacatc tggtcacagg aatgctaaat gaaacattga tggacaacaa tgagagatta
    11221 tttcaggaac tttggaaaac atatttcaag tccatttgta tcaaagaacg ttggaatccc
    11281 caaaaacacc ggcaagatat gcctgtcagg tattggaaat atctgacgga gaaacaataa
    11341 acagttcttc cggatatccc acatctacta aaaacaaggc atgtcccggc acagaactac
    11401 cggcactaca acgatcttta ttctctatca ccttcctgaa cccatctaaa gtcattttac
    11461 cacgccccac ttccaccagc gtacctacca cagcccttac catattccgt aaaaaacggt
    11521 cggctttaat agtaaatacc cattctgttc cactcacccg cgtccattca gcatacataa
    11581 tccggcaatt attcgtcttc acatcagtat gcaatttact gaaactggta aaatcagtat
    11641 aatcaaacaa tacacgggca gcctcattca ttttctcaaa atccaatgaa ttaaaaagcc
//
