LOCUS       c00314_gnlPro..        13249 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|GDKPAMKK_314.
ACCESSION   c00314_gnlPro..
VERSION     c00314_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 02:14:18
            Original ID  :: gnl|Prokka|GDKPAMKK_314
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13249
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..3249
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: HGD-D"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: BcrAD_BadFG"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg314_1"
                     /sec_met_domain="HGD-D (E-value: 1.9e-63, bitscore: 206.5,
                     seeds: 370, tool: rule-based-clusters)"
                     /sec_met_domain="BcrAD_BadFG (E-value: 5.4e-31, bitscore:
                     99.4, seeds: 18, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="TALVGEDGTLLYSFYSSNNGNPLKTTIRSIKEIYELLPKDAKIAY
                     SCSTGYGEALIKAALLLDEGEVETVSHYYAAAFFDPEVDCILDIGGQDMKCIKIRNKTV
                     DSVQLNEACSSGCGSFIETFAKSLNYTVQDFAKAAVFAQHPIDLGTRCTVFMNSKVKQA
                     QKEGAEVSDISAGLAYSVIKNALYKVIKVSDASELGRHIVVQGGTFYNDAVLRSFEKIA
                     GCEAIRPDIAGIMGAFGAALIARERHQEGAETTMLSIDKINELKYTTSMANCRGCTNNC
                     RLTINKFSGGRQYVSGNRCERGIGKEKNKDHIPNLYEYKYKRIFSYTPLTADKASRGKV
                     GIPRVLNMFENYPFWYTFFTELKYEVVLSPTSTRKIYELGIESIPSESECYPAKLAHGH
                     VTWLIRNGVKFIFYPCIPYERNEFPDAVNHYNCPIVTSYAENIKNNVDELNDPSITFRN
                     PFLAFTSEEILANRLVEEFKDIPAGEVKAAVHKGWEEMAAARRDVQKKGEETLKYLEDT
                     GRHGIVLAGRPYHIDPEIHHGIPDLINSYGIAVLTEDSISHLAPVERPIRVNDQWMYHS
                     RLYAAANYVKTRDDLDLIQLNSFGCGLDAVTTDEVYEILDGSDKIYTCLKIDEVNNLGA
                     ARIRIRSLIAAIRAKKAQGQKRTVNPASIDKVSFTKEMRKDYTILCPQMSPFHFSLLQA
                     AFNSCGYNLEVLPNDNKHAVDVGLKYVNNDACYPSLIVVGQIMDALLSGKYDLNKTAVV
                     MSQTGGGCRASNYIAFIRRALKKAGMEQIPVISVNLSGLESNPGFKLTLPLVKKVAYGA
                     VFGDILMKCVYRMRPYELEEGIVNRKHKIWEQRVISFLSGSSISHSQFKKMCREMVHEF
                     DTIPISDVKKPRVGIVGEILVKFLPAANNHLAELLESEGAEAVVPDLIDFMCYCFYNQN
                     FKVENLGFKKSKATMANWGIKAIEWVRKPASEALAQSRHFAPPADIRDLAKMASPIVST
                     GNQTGEGWFLTGEMMELIHGDVPNIVCIQPFGCLPNHIVGKGVIKEIRREYPTANIVAI
                     DYDPGASEVNQLNRIKLMLSTAQKNLKKAEEKNA"
     protocluster    1..13249
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[0:3249](+)"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1..3249
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
     cand_cluster    1..13249
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /kind="single"
                     /product="Others_HGD_unassigned"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13249
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Others_HGD_unassigned"
                     /region_number="1"
                     /rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D, HleuD1,
                     HleuD2, HleuS1, HleuS2, Lactoyl-CoA1, Lactoyl-CoA2]) and
                     minimum(1, [ACP_syn_III, ACP_syn_III_C, AcetylCoA_hyd_C,
                     AcetylCoA_hydro, Acyl-CoA_dh_1, Acyl-CoA_dh_2,
                     AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG, Biotin_lipoyl,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_6_Glutaconate, CoA_transf_3, ECH_1, ECH_2, ETF,
                     ETF_alpha, FGGY_C, HCDH, HCDH_N, Hacid_dh, Hacid_dh_C,
                     Mal_decarbox_Al, Peptidase_M22, Peptidase_M23, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and not (minimum(2,
                     [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /tool="gutsmash"
     CDS             complement(3476..5104)
                     /locus_tag="ctg314_2"
                     /transl_table=11
                     /translation="MNQKNNLVKNASFLMIAAMISKVIGLLYKSPLSNIIGSLGMGYTS
                     LAQNAYMILLMIASFSIPQAVSKLISERIALKDYRNAHKFFKGAMIYAMVIGGVVGLFC
                     LFGAGLIIPQNQKDAIPALQILAPTIFLSGILGVFRGYFQAYRNMMPTSISQIIEQVFN
                     AAVSLLAAWGFINAFSDGTENSIAKWGAAGSTVGTGAGVVTALAFMLLVYGVNRRKILH
                     RVEKDHRHQEESYKEIFRVIILVVSPIILSAFVYNVNAYINGYLFSDILGRRGGDAAQI
                     GILYAEYATYFMTIINIPLTLSSTAPTSMIPEVSALYATGDIEATRECIDQTVQLSMVV
                     SAPCAMGLAVLAQPIVFLLYGNSTGLAANLLILGSFSILLNGMSNISNGVLQAIGQQRI
                     PVITAAIALVVDIVVVVVLLFTTNLGVYALLIAMVIYSVVVCVLNDRAMKKYLQYKNPW
                     KEGYLYPVLASVPMGIVAGCICYGLNIFVKSNFICLIVSIPVAAVVYLFAYLIISKPSE
                     SQLRRIPGGSYLIRIAEKLPFWQNN"
     CDS             complement(5150..5824)
                     /locus_tag="ctg314_3"
                     /transl_table=11
                     /translation="MSAISGDWLEALKGEFHQPYYAKLYKTVMTEYQTRKIFPPADDLF
                     NAFHFTPLNEVKVVILGQDPYHNDGQAHGLCFSVKRGVETPPSLVNIYQELHDDCGCYI
                     PNNGYLEKWAKQGVLLLNTVLTVRAHQANSHRGIGWEQFTDAAIQVLNEQDRPIVFLLW
                     GRPAQMKKSMLNNPKHLILEAPHPSPLSAYRGFFGCKHFSKTNEFLVANGLEPIDWQIE
                     NI"
     CDS             complement(5857..6615)
                     /locus_tag="ctg314_4"
                     /transl_table=11
                     /translation="MFTKRIIPCLDVNNGRVVKGVNFVQLRDAGDPVEIAKAYDAAGAD
                     ELVFLDITASCEQRDTVVDMVRRVAANVFIPFTVGGGIRTVDDFKKLLREGADKISVNS
                     AAIDRPELISEAADKFGSQCVVVAIDAKRREDGGWNIYKHGGRLDTGIDAIEWAKKVEA
                     LGAGEILLTSMDCDGTKAGYDLALTRAIADAVSIPVIASGGAGTLEHFYDALTEGGADA
                     ALAASLFHYKELEISQVKDYLSDRGISVRR"
     CDS             complement(6617..7255)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GATase"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg314_5"
                     /sec_met_domain="GATase (E-value: 3.5e-30, bitscore: 96.6,
                     seeds: 97, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIAIIDYDAGNIKSVEKALHYLGEETTVTRDSQTLLNADKVILPG
                     VGSFGQAMEKLHTYGLVPVIHEIVEKKTPFLGICLGLQLLFESSEETPGVEGLGILKGK
                     IVKIPPAPGLKIPHMGWNSLHFQNNGRLFQGIPEQTCVYFVHSYYLQAEEPEIVKATTE
                     YSTCIHASVEKDNVFACQFHPEKSSKWGLKILENFAAVGKDGNTEKEGK"
     CDS             complement(7501..9045)
                     /locus_tag="ctg314_6"
                     /transl_table=11
                     /translation="MTGTGKTDKKFHTLQHQISVVFICLLLLSIFTITLINGLFLEKYY
                     VSKKVEVLEEAKEVLSQMNLDDILQYDTDIEEDKKGATDEISDEIERSSSRNNLTWIIV
                     NEENSGYYYWGENNMAKMLRSKLFGYINNLDQDMQHSRVLKKTDTCTMWQVHDRFAGME
                     YVECWGQFDNGYYFLIRSPLESIKESASISNSFYFIVGIIIIVVSGIVILVMTNRITRP
                     ISELTKLSEKMSDLDFDARYQSRAGNEIDVLGDNFNKMSRKLESTISELKSANNKLQKD
                     IEDKIKIDEMRKEFLDNVSHELKTPIALIQGYAEGLNENISDDPESREFYCEVIMDEAS
                     KMNKLVKNLLTLNQLESGKDAPVMERFDIVSLIRGVLGSMHIMIEQKEATVIFEETEPV
                     YVWADEFKIEEVVTNYTSNALNHLEGERKVEIKVLQEEDCVKVTVFNTGTPIPEEDIPN
                     LWNKFYKVDKARTREYGGSGIGLSIVKAIIESMNQKYGVCNYDNGVEFWFTLDCRQ"
     CDS             complement(9042..9722)
                     /locus_tag="ctg314_7"
                     /transl_table=11
                     /translation="MDTLKILVVDDESRMRKLVKDFLTKKNFQVLEAGNGEEAMDIFYE
                     EKDIALIILDVMMPKMDGWEVCREIRKNSKVPIIMLTARSDERDELLGFDLGVDEYISK
                     PFSPKILVARVEAILRRTGQNNPEDVISAGGIVIDKAAHLATVDGKPVELSFKEFELLT
                     YFLENQGIALSREKILNSVWNYDYFGDARTIDTHVKKLRSKMGDKGEYIKTVWGMGYKF
                     EVDE"
     CDS             complement(10513..11520)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_17"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg314_8"
                     /sec_met_domain="Fer4_17 (E-value: 1.8e-12, bitscore: 39.1,
                     seeds: 82, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 0.00045, bitscore: 12.3,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEYVTLGKTGLRVSRMGLGGIPIQKIDAEGTKTLLHKLADRGVNY
                     IDTARGYTVSEEYLGYALEGIRDRFIIATKSMARTKEAMAEDIEKSLHNLRTDHIELYQ
                     VHNPSMEQLDQVQAAGGALEALQAARAAGKIGHIGLTAHSVEVFARALELDWVETIMFP
                     YNIVESQGEELILKCEEKNIGFIDMKPLAGGAIENGTLALRYVCSNKNVTIVIPGMAEE
                     KEIEENIKACLDDSPLSEKELEEVQTVRNQLGTNFCRRCNYCAPCSVGIDISGVFLFAG
                     YLNRYGLGDWARNRYSSLAVKASACIECGKCETRCPYHLPIREMLKECAQQFGE"
     CDS             complement(11638..12195)
                     /locus_tag="ctg314_9"
                     /transl_table=11
                     /translation="MISAGDFKNGITLEIDGNVCQIVEFQHVKPGKGAAFVRTKYKNII
                     TGSVLEKSFRPTEKFPAARIERVDMQYLYDDGDLYYFMNVETYDQVGLTKDQVGDSLKF
                     VKENEMVKICSHNGNVFAIEPPLFVELEVTETEPGFAGNTAQGATKPATVETGAQVQVP
                     LFVNQGDKLKIDTRTGEYLSRV"
     CDS             complement(12339..12863)
                     /locus_tag="ctg314_10"
                     /transl_table=11
                     /translation="MNHIVIIGFMGSGKTRVGKRLAKDFNLPFVDVDRVVSKKMNLTMK
                     EIFDRFGEPFYRALETTVIKALIDDPEQKIISLGSGLPMQEQNAKYIKKLGTVVYLKGS
                     YATLKKRLENSSSNPLIEGEDKEDKIRKLLKQRDPVYTKFADVEMITGDKPFEDLIGQL
                     EEKLKTCVKNS"
ORIGIN
        1 actgcactgg taggcgaaga tggaacactt ctctattcct tttacagcag caacaacgga
       61 aacccgttaa aaactaccat ccgttctatt aaagaaatct atgaactgct tcccaaagac
      121 gcaaagatcg cttattcctg ttctacaggt tacggcgagg ctctgatcaa agcggccctg
      181 ctcctggatg agggcgaggt tgagaccgta tcccattact atgcagctgc attctttgac
      241 ccagaggtag actgtatcct ggatatcggc ggacaggata tgaaatgtat caagatccgc
      301 aacaagaccg ttgacagcgt acagttaaat gaagcatgct cctccggatg cggttccttt
      361 attgaaacct ttgccaaatc cctgaattat acagtacagg atttcgcaaa agctgctgtt
      421 tttgcacagc atcctataga tcttggtacc agatgtactg ttttcatgaa ttccaaggta
      481 aagcaggcgc agaaagaagg agctgaggta tccgatattt ccgcaggtct tgcttactct
      541 gttatcaaaa atgcactcta taaggttatt aaggtttctg atgcttccga acttggcaga
      601 cacattgttg tacagggtgg taccttctac aatgatgcgg ttcttcgaag cttcgaaaag
      661 attgcaggct gcgaagccat ccgtccggat atcgccggaa tcatgggtgc cttcggtgcc
      721 gcactgattg cccgcgaacg ccatcaggaa ggcgcagaaa cgactatgct ctccattgat
      781 aagatcaacg agctgaaata tacaacttct atggcaaact gtcgtggatg taccaataac
      841 tgccgtctga ctatcaacaa attctccggc ggccgccagt atgtaagcgg taaccgctgc
      901 gagcgtggta ttggcaagga aaagaacaaa gatcatattc cgaatcttta tgaatataaa
      961 tataaacgta ttttctccta cacaccgctt actgctgata aggcatccag aggtaaagta
     1021 ggtatccccc gtgttctgaa tatgtttgag aattatcctt tctggtatac tttctttaca
     1081 gaactgaagt atgaggttgt gctctctcct acttccacca gaaagattta tgagctgggt
     1141 attgagtcca ttccaagtga atctgaatgc tatcctgcca aacttgccca tggccatgta
     1201 acctggctga tccgcaatgg cgtgaaattt attttctacc catgtatccc atatgaacgt
     1261 aacgagttcc cggatgcagt caaccactat aactgcccga tcgttacctc atatgccgaa
     1321 aatatcaaga ataacgtaga cgaattaaac gatccgtcca ttaccttccg caatccgttc
     1381 cttgcattta cttctgagga aattctggca aatcgtctgg tagaggaatt taaggatatc
     1441 ccggcaggag aagtcaaagc tgctgtgcat aagggctggg aagaaatggc tgctgcacgc
     1501 cgcgatgtac agaaaaaagg ggaagaaacc ctgaaatatc tggaagatac aggacgccat
     1561 ggtattgtcc ttgcaggacg cccataccat attgacccgg aaatccatca tggtatcccg
     1621 gatctgatca acagctatgg tattgccgta cttaccgagg attccatctc tcatctggcg
     1681 cctgtggaac gcccgatccg cgtcaatgac cagtggatgt accactccag actgtatgct
     1741 gccgcaaact atgtaaagac acgcgatgat ctggatctga tccaactgaa ctctttcgga
     1801 tgtggtctgg atgcagttac tacagacgag gtttatgaaa tccttgacgg aagtgacaaa
     1861 atctatacct gcttaaagat tgacgaggta aataaccttg gcgctgcaag aatccgtatc
     1921 cgttccctga tcgcagcgat ccgtgcgaag aaagcacagg gacagaaacg tactgtcaat
     1981 cctgcttcta ttgataaagt atcctttaca aaggaaatga gaaaggacta taccatcctc
     2041 tgcccgcaga tgtcaccgtt ccatttcagc ctcctgcagg cagcattcaa ttcctgcgga
     2101 tacaacctgg aggtgcttcc gaatgacaat aagcatgcag tggatgttgg tctgaagtat
     2161 gtaaacaatg acgcctgcta tccgtctctg atcgttgtgg gacagatcat ggatgctctg
     2221 ctttccggta aatatgacct gaacaaaacg gccgttgtca tgtcacagac aggtggcgga
     2281 tgtcgtgctt ccaactatat cgcatttata cgacgcgcat taaagaaagc cggtatggaa
     2341 cagattccgg ttatctctgt gaacttaagc ggtctggaaa gcaatcccgg attcaaactt
     2401 acgcttccat tagtgaagaa agttgcttac ggtgccgtat tcggagatat cctgatgaaa
     2461 tgcgtatatc gtatgcgtcc ttatgaactg gaagagggaa tcgtaaacag gaaacataaa
     2521 atctgggaac agcgtgtgat ctctttctta agcggaagca gtatcagcca cagccagttt
     2581 aagaaaatgt gccgcgaaat ggttcacgaa tttgatacca ttccgatcag tgatgtgaaa
     2641 aagcctcgtg tcggcatcgt aggtgagatc cttgtcaagt tcctgcctgc tgcaaataat
     2701 catctggcag agcttctgga atctgaaggc gctgaggcag ttgtaccgga tctgatcgat
     2761 ttcatgtgct actgcttcta taatcagaac tttaaggtag aaaatcttgg attcaagaag
     2821 tccaaggcaa ccatggcaaa ctggggaatc aaagcaatcg aatgggtgag aaagcctgca
     2881 agcgaagctc ttgcacagag ccgccatttt gcaccgcctg ctgatatcag agatctggca
     2941 aaaatggcat ctccgatcgt ttccaccgga aaccagacag gtgagggatg gttcctgaca
     3001 ggtgagatga tggaactgat ccatggagat gttccgaata ttgtttgtat ccagcctttc
     3061 ggatgtctgc cgaaccacat tgtaggtaag ggtgttatca aagaaatccg cagagaatat
     3121 ccgacagcca atattgtagc catcgactat gacccgggcg caagtgaagt caatcagctg
     3181 aaccgaatca aactgatgct ctccacagct cagaaaaacc tgaaaaaagc agaagaaaaa
     3241 aatgcataaa taataccgta atggatatat tgcaatgtat tttaccttgc aatatatcca
     3301 ccttagagtg tgtctgaaaa atcattcccg caatctacat atcctgcttt gcgaaaagca
     3361 tttttcaaac gcgctcaaaa aagagttata tttcagaaat tttaaatgtg tttctatttc
     3421 agaaatacat ttaaaccatg aaatataact cttttgtttt ttataatttc agtgtttaat
     3481 tattctgcca gaacggaagt ttctctgcaa tccttatcag atagcttcca cccggaattc
     3541 ttctaagctg tgattctgac ggcttgctga tgatcaggta agcaaacaga taaacaaccg
     3601 cagcaacagg aatggaaaca atcagacaaa tgaaattgga ttttacaaaa atgttcagtc
     3661 catagcagat acagcctgca acaattccca tgggaacaga tgcaagaaca ggatacagat
     3721 atccttcttt ccatggattc ttatactgca gatatttctt catggctctg tcatttaaca
     3781 cacatacaac cacagaatag atcaccattg cgatcagcag tgcataaact ccaaggtttg
     3841 tagtaaacag cagcactacc actaccacaa tatccacaac cagtgcgatt gctgccgtaa
     3901 tcaccggaat cctctgctgt ccgatcgcct gcagaactcc attggaaata tttgacattc
     3961 cattgagcag gattgaaaaa gaaccaagga tcagcaggtt ggctgccagt cctgtggaat
     4021 ttccgtaaag caaaaataca atcggctgtg caagcactgc cagtcccatg gcacatgggg
     4081 cggaaactac catagaaagc tgtacggtct ggtcaatgca ctctctggtc gcttcaatgt
     4141 ctccggtggc atacagggcg gaaacttccg gaatcatgga agtaggtgcc gtactggaca
     4201 gcgtcagagg aatattaata attgtcataa agtaagtagc atactctgca tataaaatac
     4261 caatctgtgc cgcatctcca cctcttcttc ccagaatatc cgagaaaaga tacccattga
     4321 tataagcatt tacattataa acaaaggcgc tgagaatgat cggcgaaaca accaggatga
     4381 tcacacgaaa aatctctttg taggactctt cctgatgtct gtggtccttt tctacccggt
     4441 gcaggatttt tctgcggttt acaccataca ccagaagcat gaatgccaat gcagtcacca
     4501 ctccggctcc ggttcctact gtggaacctg ctgcccccca ttttgcaatg ctgttctctg
     4561 ttccatctga gaatgcattg atgaatcccc aggctgccag aagactgact gccgcattaa
     4621 atacctgctc aataatctgg gagatagatg ttggcatcat atttctgtat gcctgaaaat
     4681 atcctctgaa taccccaaga ataccggaca aaaaaatcgt cggagccagg atctgaagtg
     4741 ccggaattgc atccttctga ttctgaggga tgatcagccc tgctccaaag agacagaata
     4801 aaccgaccac tccgccaatc accatggcat agatcatggc acccttaaag aacttatgtg
     4861 catttctgta atccttcaga gcaatacgct cggagatcag cttggatacc gcctgtggaa
     4921 tactaaagga tgcgatcatc agaaggatca tataggcatt ctgtgcaaga cttgtatagc
     4981 ccattccaag gcttccgata atattggaaa ggggactctt gtacagaaga ccgatcacct
     5041 tggagatcat agctgcaatc atcagaaagg atgcattttt tactaaattg tttttctgat
     5101 tcatgttatc actgtgtgtc ttttacctga ctacacatta cctcttttct tatatatttt
     5161 ctatctgcca gtcgattggt tccagaccat tggcaacaag aaattcgttt gttttactga
     5221 aatgtttaca tccgaaaaat cccctgtaag cagacaaagg acttggatga ggtgcctcca
     5281 gaatcagatg cttcggatta ttcaacatgg attttttcat ctgcgccgga cgtccccaga
     5341 gcagaaatac aataggacgg tcctgctcat tcagaacctg gatcgcagca tccgtaaact
     5401 gctcccagcc gatccccctg tgtgaatttg cctgatgggc gcgtacagtc agaactgtgt
     5461 tcagaagaag caccccctgc ttcgcccact tctccagata gccgttattg ggaatatagc
     5521 atccacagtc atcatgaagc tcctgataaa tattcaccag ggacggcggc gtctccactc
     5581 ctctctttac ggaaaaacaa agcccatgag cctgcccgtc attatgatag ggatcctgac
     5641 ccagaatcac taccttcact tcgtttaacg gtgtaaaatg aaatgcatta aacagatcat
     5701 ccgcaggagg aaaaatcttc ctggtctgat attctgtcat caccgtttta tataattttg
     5761 cataatacgg ctggtgaaac tctcccttca gggcttccag ccagtcacct gaaattgctg
     5821 acatacctta tccttcacct cttatatttt tcgtggtcat cgtctgacag aaattcccct
     5881 gtcagacaga taatccttca cctgagaaat ctccagttct ttataatgga acaaagacgc
     5941 agccagtgca gcatctgctc ccccttcggt cagtgcatca taaaaatgct ccagtgtacc
     6001 tgcgccgcct gatgcgatca caggaatgga gacagcatca gcgattgctc tggtaagagc
     6061 cagatcatat cctgcttttg taccgtcaca gtccatactg gtgagaagga tttcccctgc
     6121 gcccagagct tccactttct ttgcccactc tatggcatca atccctgtat ccagtcttcc
     6181 gccatgtttg taaatattcc atccgccgtc ttctctgcgc ttggcatcaa tagccacaac
     6241 tacgcactgg cttccaaact tgtcagccgc ctcactgatc agttccggtc tgtcaattgc
     6301 tgcagaattt acggaaatct tatctgctcc ttctctcagc agtttcttga aatcatctac
     6361 agtacggata ccgccgccta ctgtaaacgg gataaataca ttggcagcaa cccgtcttac
     6421 catgtcaact accgtatccc tctgttcgca ggatgctgta atatcgagaa ataccagttc
     6481 atctgctcct gctgcatcat aggctttggc aatctccacc ggatcacccg catcgcgaag
     6541 ctgcacaaaa tttacgccct ttaccacacg tccgttattt acatccaggc agggaataat
     6601 tctctttgta aacattttat tttccctcct tctcagtatt gccgtctttt cccacagcag
     6661 caaaattttc aagtatcttc agtccccatt tgctgctctt ttccggatgg aactggcagg
     6721 caaatacatt gtccttttct acggaagcat gaatacaggt gctgtattct gtagtagcct
     6781 ttacaatctc aggctcctct gcctgcagat aataagaatg cacaaaatat acacaggtct
     6841 gttccgggat tccctgaaac agtctgccat tattctgaaa atgcagggaa ttccatccca
     6901 tatgtggaat cttaagcccg ggcgcaggcg gaatcttaac aattttccct ttcaggattc
     6961 caaggccttc cacccccggt gtctcctcgc tgctttcaaa aaggagctga agtcccaggc
     7021 agattccaag aaatggcgtc ttcttctcta caatctcatg gatcacaggt acaagtccgt
     7081 atgtatgaag tttctccatc gcctgtccaa agcttcccac gcccggcagg attactttat
     7141 ccgcatttaa caaagtctgc gaatcgcggg ttactgttgt ttcttcccca agataatgaa
     7201 gtgctttttc tacactttta atatttccgg catcatagtc aattattgca atcatgttat
     7261 cctcctgacg tcattatctg ttttcctcat tatggtaatc cgaaggcttt ccggatcaca
     7321 tgtcagaccg gaataaaata tccgttcaaa acgctccaat acagtataac ccaaaaacag
     7381 acagttgcaa agtgctttct ttgcttctgt ctgtttttat tccggtcata ctaccggtta
     7441 ctgttcactc cgttcacagt aacacgcttc tcactacgtt cacaatatcc ggatatctta
     7501 tcactgcctg caatccagag tgaaccagaa ctccacgcca ttatcataat tgcatacccc
     7561 atatttctgg ttcatactct caatgattgc cttaacaatt gaaagtccga taccacttcc
     7621 gccatattct cttgtccggg ccttatctac tttgtagaat ttattccaga gatttgggat
     7681 atcctcttcc ggaatcggag tacctgtatt aaatacggtt actttcacac agtcctcttc
     7741 ctgaagaacc ttaatttcta cttttcgttc tccttccaga tggttcagtg cattgcttgt
     7801 ataattggtc acaacctctt caatcttaaa ctcatccgcc catacatata caggttctgt
     7861 ttcttcaaaa atcacagttg cttctttctg ttcgatcata atatgcatag aaccaagtac
     7921 acccctgatc agagatacaa tgtcaaatct ttccatcacc ggggcatctt taccggactc
     7981 cagctgattc agcgtcagca ggtttttgac cagcttgttc atctttgaag cctcatccat
     8041 aataacttca cagtaaaatt ccctgctttc cggatcatcg gaaatatttt cattcagccc
     8101 ctctgcatat ccctggatca atgcaatagg agttttcagc tcatgagaaa cattatcaag
     8161 aaattcctta cgcatctcat caattttaat cttatcttct atgtctttct gaagcttgtt
     8221 attagccgat ttcaactctg agatcgtgct ctcaagtttt ctggacattt tgttaaagtt
     8281 atcgccaagt acatcaatct cattacctgc cctgctttga tatctggcat caaaatccag
     8341 atcagacatc ttctctgata atttggtcag ttcactgatc gggcgggtaa tacgatttgt
     8401 catcacaaga atcacaatac cgctgaccac aattatgatt attcctacaa tgaagtaaaa
     8461 actgttggaa atagatgcac tttccttaat actttccaga ggagaacgga tcaggaaata
     8521 gtaaccatta tcaaactgtc cccagcattc cacatattcc atgcctgcaa agcgatcatg
     8581 cacctgccac atggtacagg tatctgtctt tttgagcaca cgactgtgct gcatatcctg
     8641 atccagatta ttaatatacc caaacagctt actgcggagc atttttgcca tattattctc
     8701 tccccagtaa taataaccgc tgttttcctc atttactatg atccaggtaa ggttatttct
     8761 ggaactgctc ctctcaatct catccgaaat ctcatctgtt gccccttttt tgtcctcttc
     8821 tatatctgta tcatactgca ggatgtcatc cagattcatc tgagacaaca cttcttttgc
     8881 ctcctccagc acttctactt ttttggatac ataatatttt tcaagaaaaa gaccattgat
     8941 cagagtaatg gtaaagatcg aaagcagtaa cagacatata aacactactg aaatctgatg
     9001 ttgcagagta tgaaattttt tatctgtttt tccggttcct gtcattcgtc tacctcaaac
     9061 ttgtatccca taccccatac agtctttata tattcacctt tatctcccat tttacttctg
     9121 agcttcttaa catgggtatc aatcgtacgg gcatctccaa agtagtcata attccataca
     9181 gaattcagga tcttttctct ggaaagtgcg attccctgat tctccagaaa atatgtcaga
     9241 agttcaaatt ccttaaagct cagttccaca ggcttaccat ccacagtagc cagatgtgct
     9301 gctttatcta taacaatgcc gcctgctgaa atcacatctt ccggattatt ctgacctgta
     9361 cgtctcagaa ttgcctccac tcttgcaaca aggattttcg gactgaatgg tttggagatg
     9421 tattcatcta cccccagatc aaatccaaga agctcatctc tctcatcact tcttgcagtc
     9481 agcataatga tcggaacttt tgagttcttg cgaatttcac gacaaacttc ccatccatcc
     9541 atcttcggca tcatgacatc cagaataatc agtgcgatgt ccttctcctc ataaaagata
     9601 tccatggctt cttcaccatt accggcttcc agtacctgga aattcttctt tgtcaggaaa
     9661 tcctttacca gctttctcat gcggctctca tcatccacca ccaggatttt taatgtatcc
     9721 atttgatccc ctccgttttt cttcattatt ttccgaaaca gtttttactt tttatttata
     9781 ctgttttccg agtattgtta aaatccacga ctgttcagcg cctttacagc cacagcgcaa
     9841 aatccgggaa aatcgccctc agcaacagat tttacctttc atatggttac tatagcagag
     9901 atttatgtaa gatttgtgaa catatgacag aaaaattata agtattgccg ttcacaacac
     9961 caaacagcct caaatataaa aatcttcttg acaaattctg tttttatttc tatactgtta
    10021 atcagtcgat atatcttata taatgaatga tatatcaata ttaaaaagtg ctttcgtctc
    10081 atcaccagtg ctgttttatg aaaaaacagc gttgcagact cattttcagg gcttgtactg
    10141 gtttcgacgg gggctttgaa gttggggaag ccatccgcag actcccagac tgcgtaccaa
    10201 tcgggaaact aaatataaac gcagacgaac agtacgcgtt agcagcctaa ttgctgctcg
    10261 tcagccctga tgcactcaca cttcaggaat ctgacgtcga ccatgtgaga aaccttgccg
    10321 ggtaagcttt gccccggtag atgtatcatg aagctactaa ggttgtaagc ctgtcggtgg
    10381 gcgtacatcc aagggaatgt taaaacagcg actgtgatgg gagatgcctc aatgaatagg
    10441 ctttcggacg cgggttcaat tcccgccagg tccataaaaa acatccacag ggtaattccc
    10501 tgtggatgtt ttttattcac caaactgttg tgcacattct ttcagcattt cgcggattgg
    10561 cagatggtac ggacatctgg tttcacattt gccgcattct atacaggcag aagccttcac
    10621 cgcaagagaa ctgtaacggt ttcttgccca gtctcccagc ccgtaacggt taagatagcc
    10681 tgcgaacagg aacacacccg aaatatcgat tcccacactg catggagcac agtaattaca
    10741 tctgcggcag aaatttgtgc caagctgatt ccgtactgtc tgaacttcct ccagttcttt
    10801 ctcgcttaac ggggaatcat caagacaggc ctttatattc tcctcgattt ccttctcttc
    10861 cgccattccc gggatcacaa tagtaacgtt cttattcgaa cagacataac gcaatgccag
    10921 cgttccattt tcaattgcac caccggccag aggtttcata tcaataaagc cgatgttttt
    10981 ctcctcacat tttaagatca gctcttcccc ctgactctct acaatattat atggaaacat
    11041 aatagtttcc acccagtcaa gctccagagc ccgggcaaaa acctccacag aatgagcggt
    11101 cagaccaata tgtccgattt ttcctgctgc tcttgccgcc tgcagtgctt caagggcacc
    11161 accggccgcc tgcacctgat caagctgttc catactcgga ttatgcacct ggtataattc
    11221 aatatgatct gtacgaagat tatgaagact cttctcaata tcttcagcca tagcttcctt
    11281 tgtacgtgcc atggactttg tggcaattat aaatctgtcc ctgatacctt ccagtgcata
    11341 tcccagatat tcttcactga ccgtatatcc tctggctgta tcaatataat ttactccccg
    11401 gtctgccagc ttatgcagca gtgtctttgt tccttccgca tcaattttct ggatcggtat
    11461 cccgccaagg cccattctgg aaaccctgag accggttttt ccaagcgtta catattccat
    11521 atttttttct cctattttca atcagagata aaaaactgcc accggatctt accgatggca
    11581 gtttttatct ctttacatct gtcgatcaga caaaacaaac aactggtttc atcctgatta
    11641 tactcgagaa agatattctc ctgttcttgt atcgattttc agtttgtcgc cctggttaac
    11701 gaacagcgga acctgaacct gtgcacctgt ttctacagta gccggttttg tagcaccctg
    11761 tgctgtattt ccggcaaatc ccggctctgt ctcagtaact tcaagttcta cgaacagagg
    11821 aggctcaata gcaaatacat ttccgttgtg ggaacagatc ttaaccatct cgttctcttt
    11881 aacgaattta agagaatctc caacctgatc ttttgtaaga ccaacctgat cgtatgtctc
    11941 tacgttcatg aagtagtaca gatcaccatc atcatacaga tactgcatat ctacacgctc
    12001 aatacgtgca gccgggaatt tctctgttgg acggaaagac ttctcaagaa ctgatcctgt
    12061 aataatgttt ttgtattttg ttcttacgaa agcagcaccc tttcctggtt ttacgtgctg
    12121 gaattcaacg atctgacata cgtttccgtc aatttcaagt gtgataccgt ttttgaaatc
    12181 acctgctgaa atcatagtta tatttcctcc ttaatagtac agttcagcaa tgctgtgtct
    12241 tttgacaaca acagccgttc aaagtgtgtg tccctctcat gcttttctca gttttgtgac
    12301 acactcttat ttaattttat aatattctgc tgtttttttc aactattttt tacacatgtt
    12361 tttaattttt cttcaagctg accaatcaga tcctcaaatg gcttgtctcc tgtgatcatc
    12421 tcaacatctg caaactttgt ataaaccgga tcgcgctgtt taagaagttt tctgatctta
    12481 tcttctttgt cttctccctc gatcagagga ttgctgctgg aattttccag tctcttcttc
    12541 aacgttgcat aagatccctt caaatatact acagttccca gttttttaat atattttgca
    12601 ttctgttcct gcatcggaag accggacccc agagaaatga tcttctgttc cggatcatcg
    12661 atcagcgcct tgatcacagt tgtctcaaga gctctgtaaa atggttctcc gaatctgtca
    12721 aagatttctt tcattgtaag gttcatcttc tttgatacta cgcggtcaac gtctacaaaa
    12781 ggaagattga aatcttttgc cagccgtttt cctactcttg tcttacctga acccataaat
    12841 cctatgataa caatatggtt catgaattcc cctcctcttt gcggtaaaaa tatagtacaa
    12901 ttctttcaag atatcgtttc agtacgatct gaatctcttc tttcggattg agtggtttca
    12961 ccagaatatt ccggattcct gtgcgtttcg caccatatat atcagtaaag agctgatctc
    13021 ctataaaaac tgtattactt ctgtctgtcc caagaagttc cattgccctg atataatttt
    13081 ttgttgaagg cttgtgtgca ttctcgataa actgcgctcc tatcgcatca ttaaaagaag
    13141 aaactctctc gtactggttg tttgacagaa aacagcattt aaatccaagt tccttcagat
    13201 gtgcaaacaa cgcacatgct ctctcatctg ccggtgcacc atgaggtac
//
