LOCUS       gnlProkkaKIBFGNFI_108  13356 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|KIBFGNFI_108.
ACCESSION   gnlProkkaKIBFGNFI_108
VERSION     gnlProkkaKIBFGNFI_108
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 20:19:26
            Original ID  :: gnl|Prokka|KIBFGNFI_108
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13356
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13356
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[1609:3356]"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1610..3356
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
     cand_cluster    1..13356
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /kind="single"
                     /product="ranthipeptide"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13356
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="ranthipeptide"
                     /region_number="1"
                     /rules="(TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085
                     or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /tool="antismash"
     CDS             2..145
                     /locus_tag="ctg108_1"
                     /transl_table=11
                     /translation="MINLPVPRMWLANPHSILRGGFSLSRAKAVFIPPAKLVVVARSSY
                     PI"
     CDS             complement(195..1613)
                     /locus_tag="ctg108_2"
                     /transl_table=11
                     /translation="MSMTTPIVDFVRSYAKSGTARLHMPGHKGQSLLGFEPLDITEICG
                     ADELYAPEGIIAESEANATRLFGTAHSYYSTEGSSQCIRAMLFLALQGAPQNGKRPVLL
                     AARNAHKALLYAAALLDFDIRWLWPSAQAEGALCSCPVTAEALTGALHAMAQQGNTPFG
                     VYVTSPDYLGGVQELPALAAVCRAQDVPLLVDNAHGAYLRFLPQNCHPIAQGAAMCCDS
                     AHKTLPVVTGGAYLHLAHDAPVQDEAAVRGALALFGSTSPSYLILQSLDACNAVLAGDY
                     PRRLVQCCAALEGLRRSLNKAAAARQCPVPLAVAGAQQEPMKLTLDAAALGCTGTALAD
                     ALRRAQLECEYADPRYVVLMFTPENPPQDFERLQTALEQLLAAVPAGLSRPENRAGEFA
                     ALQQQAVQRCTIRQAVLGAQVRVPVHKALGRVCAMPTVSCPPAIPVAVSGEEITPAAIA
                     LMQRYGIKELSVLR"
     CDS             complement(1610..3061)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR04085"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: Ranthipeptide_rSAM_RRE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg108_3"
                     /sec_met_domain="Ranthipeptide_rSAM_RRE (E-value: 8.5e-31,
                     bitscore: 97.0, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 1.4e-15, bitscore: 48.6,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 1.1e-16, bitscore: 52.5,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 2.3e-20, bitscore:
                     63.6, seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVHQYQLNGYNIVLDTCSGSVHVVDEVAYDVIAMYPEHTADEIVA
                     AMLAKYGSRPDVTEEDLRQCIDDVTSLKENGKLWSPDVYKDMAFDFKNRNTVVKALCLH
                     VAHSCNLSCSYCFASQGRYHGDRALMSFEVGKRAMDFLIENSGTRRNLEVDFFGGEPLM
                     NFDMVKKLVAYCREQEKIHNKNFRFTMTTNGVLIDDDVIDFCNKECHNVVLSLDGRKEV
                     NDRFRVDCAGNGSYDRIVPKFQEFVKKRGDKNYYMRGTYTHFNTDFTNDIFHMADLGFT
                     ELSMEPVVCDPSDPSALTEADLPILKEQYEILAKEMIKRDREGRGFTFYHYMIDLTGGP
                     CIYKRISGCGSGTEYMAVTPWGDLYPCHQFVGDPKYLLGDIWKGVTNTAVRDEFKHCNA
                     YARKECQDCWAKLYCSGGCAANSYHATGSITGVYEYGCELFKKRMECAIMIKVAENQEL
                     AAKGIEVPIELGSTCNACADGEACE"
     CDS             complement(3129..3356)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: SCIFF"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR03973"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg108_4"
                     /sec_met_domain="TIGR03973 (E-value: 1.1e-25, bitscore:
                     80.1, seeds: 29, tool: rule-based-clusters)"
                     /sec_met_domain="SCIFF (E-value: 6.2e-25, bitscore: 77.7,
                     seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MISYYKIKAYRNYVRRDKILRVREVSIMERIKTIATRDLTKSVKT
                     GGCGECQTSCQSACKTSCGVANQQCENSNK"
     CDS             3468..3593
                     /locus_tag="ctg108_5"
                     /transl_table=11
                     /translation="MCIIEHFGNADAVPQPPEWCLSRKAGIVRCCPKPFYPPMGW"
     CDS             complement(3572..3739)
                     /locus_tag="ctg108_6"
                     /transl_table=11
                     /translation="MKRNEMMFDMEVDTDLIEQRIYERQALLCRYRYLLARARELGLHT
                     VLTRYQPMGG"
     CDS             complement(3714..4049)
                     /locus_tag="ctg108_7"
                     /transl_table=11
                     /translation="MLLYGKSPELSSIFLKKVVLFWKMPQQRRIIYAGALPHFGRFCAP
                     HRLYWKVQNLAKYQKEDAYAGTNHTKRPDPAFAPRPAGYRARALPPGAGGGTEGMPVLF
                     EAQRDDV"
     CDS             complement(4184..4333)
                     /locus_tag="ctg108_8"
                     /transl_table=11
                     /translation="MKSELLNADALLFRHSSKIQSGNRVMTLQVLKSHGLAAVVRNDIN
                     RKAT"
     CDS             4455..4631
                     /locus_tag="ctg108_9"
                     /transl_table=11
                     /translation="MRSAFALRIISGISFLLEIQKSLRAFLNLLFTSGVVTVNCICNSD
                     HHLTIAALPVKMG"
     CDS             complement(4733..6427)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1283:2`,3`-cyclic-nucleotide 2`-phosphodiesterase
                     (Score: 252; E-value: 2.1e-76)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg108_10"
                     /transl_table=11
                     /translation="MAIGAPAASACWYGDKSDVTILYTNDVHTYIDKQSPKLTYAAIAD
                     LKQSYQNAGKDVLLVDAGDHVQGTAYGSMDEGASIIKLMNAAGYDVATPGNHEFDYGMD
                     RAKAIMKEADFPYLSCNWVDLRTTLRVLPSVKVFVRGGRRIAFVGVTTPETFTKSTPAY
                     FMDKAQRKYIYDIQGGEDGKKLYDAVQKAIDKAKLLADVVIGLGHLGVDPSSSPWTSEE
                     VIAHTSGFDAFIDGHSHTVMENKQVQDASGKAVTLTQTGSYFANVGEMTIAADGTITTK
                     LIPTHEGMDAGIAAMQTSWVNTVDDMLGEKIAVGDSDFYVSDPATGKRRIRSAETNLGD
                     FVADGIYTYFNEVEKLHCDVAIMNGGGIRADVPAGDWTFKTCKQISPFGNVACLMSVTG
                     KQIQDALEFAARFAGEDGKENGGFLQVAGATYEIHTDIPNTVQTDEKNVWIGSATGTPR
                     VQNVKIYDKASGSYLPLDPGATYALAGMNYTLRNLGDGFAMFDGAELIKDYVSEDYLVM
                     STYAMIFDGADAAGLPHLSSANSPLAAYPGYLLNYEQPYGAGRITIL"
     CDS             complement(6384..6530)
                     /locus_tag="ctg108_11"
                     /transl_table=11
                     /translation="MRYAKNKRRSFSCETTYFPSQLFKGCWCDRCRCIHGHRCACRIGL
                     LVW"
     CDS             complement(6568..6804)
                     /locus_tag="ctg108_12"
                     /transl_table=11
                     /translation="MRSSSRSITPSDISLSSDRPGNGSTPPKKDLSAALRQGTGRSFLC
                     KNGTICVKIKQSVKIICAKRMILACLRRRSVLC"
     CDS             complement(6770..8701)
                     /locus_tag="ctg108_13"
                     /transl_table=11
                     /translation="MYAFPANKGGCKKSIHRAKFVCCSSSLCGVYCCHREQHDEGCENK
                     TLKQGGFFMYYSSGNYEAFATPKKPEGVDHKSAYIIGSGLAALTAACYLVRDGQMKGEH
                     VHVFEKNALAGGACDGYKYDIGYVMRGGREMDNHFEVMWDLLHSIPSLETEGASVLDEY
                     YWLNKEDPNFSLCRATVNRGEDAHTDGKFGLSDKGAMEIMKLFFTPDEQLQDKKITDFF
                     DDEVLNTNFWMYWRTMFAFENWHSALEMKLYLKRYIHHIGGLPDFTALRFTRYNQYESI
                     ILPMVRYLESFGVQFHYNTKVTDVKFDIQKGRKLASSVTVEHAGETSNIDLTENDLLFI
                     TNGGCVESCTVGAQNKATGFDPTIQPGNGWDLWKKIAAQDPSFGHPEKFCSEPELSNWE
                     SATITTLDDKIPQYIRKICKRDPFSGHTVTGGIVTVKDSSWLLSWTLNRQQQFKDQPKN
                     QLCVWVYGLFSDKPGDYVKKPMRDCTGREICMEWLYHIGVPEDQIAELAEHSANTVPVM
                     MPYIDAFFMPRAMGDRPDVVPEGAVNFAFLGQFAETARDTIFTTEYSMRTGMEAVYTLL
                     NIDRGVPEVWGSTYDVRALIDATVKLRDGKKITDMDLPLIPRLALKEALKKIEGTDLEK
                     FLKEYNAI"
     CDS             complement(8981..9244)
                     /locus_tag="ctg108_14"
                     /transl_table=11
                     /translation="MSKEFSFPNKGTCSKQTNFVLNDDHTIASIEVIGGCNGNLKGICQ
                     LLTGMKAEDAIARLDGTLCGFRSTSCPDQIAKNLKKALEEMN"
     CDS             complement(9250..10110)
                     /locus_tag="ctg108_15"
                     /transl_table=11
                     /translation="MSCDLHIHSTCSDGAVPIERLASIAARTGLHAIALSDHDTLLSAQ
                     YAYAHTGQDGVELIPAVELTGYDFERQHRVHLLCYYPDVDCPALREHCAIMKERRNACA
                     LQSAKELEQLYPQFTTDLAWETTKASGVLFKSGLMQALELLGLTDGSIYGETYHKLFGW
                     NPRGIVLHSPEYLPVRQVLATAKASGGAVVFAHPTVYKSMPLLRELVAEGAVDGIEVYH
                     PSNSPEDSAECLALCKQYGLVATAGTDFHGRNHKHPHPIGTCTAPDEAAAQLRVIAEKR
                     KRERT"
     CDS             complement(10125..12569)
                     /locus_tag="ctg108_16"
                     /transl_table=11
                     /translation="MRVLLPRNTPHPVLCATFPQGVKAKGTAVFGMNSRTAGAMPAIAA
                     GGKIQKERRIEMLDMIKCSTGGAYYARGEWVPADGNAPAALAAKGFDAAAVAAAKTGTM
                     AYNIMQAHNTSGDAENLKIKFDAMASHDITFVGIIQTARASGLEKFPIPYVLTNCHNSL
                     CAVGGTINEDDHRFGLSAAKKYGGIFVPPHMAVIHQYMRERFAGCGKMILGSDSHTRYG
                     ALGTMAIGEGGGELAKQLLGRTYDVARPGVVAIYLTGSLPAGCGPHDVAIALVGKLFKS
                     GYVKNKVMEFVGPGIASLRQDTRNAIDAMTTETTCLSSIWETDEVTQRFLAVHGRAADY
                     KKLAPADLAYYDGVVEVDLSAIRPMIALPMHPSNAFTIEELNANLEDILHACEQDVQKL
                     IGRKDVQLDLCSKIENGKLRVDQGVIAGCAGGLYDSIYEAASILKGHTGGCGDYALSVY
                     PGSQPIMMELVRTGVIGELMASGATIRTAFCGPCFGAGDVPANGALSIRHTTRNFPSRE
                     GSKPGSGQLAGVALMDARSIAATTANGGILTPATDIDYDPTVPEYQYDASSYDTRVYQG
                     FGKGDYDALLKFGPNIKDWPEIAPLGDNLLLKVVSYITDPVTTTDELIPSGETSSYRSN
                     PLGLAEFTLSRKDPEYVSRAKAVQAEEAARRAGAGDAALLAKVNAVPGCEQLSWNDIQI
                     ASTIFAVKPGDGSAREQAASCQRVLGAGANIVTEYATKRYRSNLINWGMLPLQLAGATP
                     FGLGDYVLIPNVREALKGDLQNIKAYVLGDTVKEFELYMAPLTTDERQILADGCLINFY
                     KH"
ORIGIN
        1 aaagataaac ctccctgttc ctagaatgtg gttggcaaac ccacactcta ttctacgggg
       61 aggtttctct ttgtctaggg ctaaagccgt ttttattcca ccagcaaagc tggtggttgt
      121 cgctcgctca agctacccaa tatagagaac ccggaaggtc cgcagacctt ccgggttctc
      181 ttcttataaa atctttatcg cagcaccgag agttctttga tgccgtagcg ctgcatcagg
      241 gcgatggctg ccggggtgat ctcctcgccg ctgaccgcca cagggatggc gggcgggcag
      301 gacaccgtag gcatggcaca cacccgtccc agtgccttgt gcaccgggac gcgcacctgt
      361 gcacccagca ccgcctgccg gatggtacag cgctgcaccg cctgctgctg caaggcggca
      421 aactctcctg cccggttctc ggggcgggac agtccggcag gcacagcagc cagaagctgt
      481 tccagcgccg tttgcaggcg ttcaaagtcc tgcggcgggt tttccggggt gaacatcagc
      541 accacatagc gggggtcggc atactcgcac tccagctgtg cgcggcgcaa agcatctgcc
      601 agcgctgtgc cggtgcagcc aagggcggcg gcgtccagcg taagcttcat cggctcctgc
      661 tgtgccccgg caactgccag cggcaccggg cactgccgcg ccgctgcggc cttattcagg
      721 ctgcggcgca gaccttccag cgccgcgcag cactgcacca gccgccgggg gtagtcccct
      781 gccagcaccg cattgcaggc atccagcgac tgcaaaatga ggtaagaggg gctggtagag
      841 ccgaacagcg ccagcgcccc ccgcacagcc gcttcgtcct gcacaggggc atcgtgcgcc
      901 agatgcagat acgcaccgcc ggtgaccacc ggcagagtct tgtgggcaga gtcgcagcac
      961 atggccgcgc cctgtgcgat ggggtggcag ttctgcggca gaaagcgcag gtaggccccg
     1021 tgggcgttat ccaccagcaa aggcacgtcc tgcgcccggc agacagcggc cagcgccggg
     1081 agttcctgca ccccgcccag ataatccggg ctggtgacgt acacgccaaa gggggtgttg
     1141 ccctgctgtg ccatcgcgtg caaagcccct gtcagcgctt cggctgtgac ggggcagctg
     1201 cacagtgcac cctctgcctg cgcagacggc cagagccagc ggatatcaaa atccagcagc
     1261 gccgccgcat acagcagcgc cttgtgggcg ttgcgggcgg ccagcagcac cgggcgctta
     1321 ccgttttgcg gtgcgccttg cagcgccaga aacagcatgg cacggatgca ctgagacgac
     1381 ccctcggtgc tgtaatagct gtgcgccgtg ccgaacagcc gggtggcgtt ggcttcactc
     1441 tcggcaataa tgccctccgg cgcgtaaagc tcgtccgcac cgcagatctc ggtgatatcc
     1501 agcggctcaa agcctaaaag gctctgcccc ttgtggccgg gcatatgcag ccgggcggta
     1561 ccggactttg catagctgcg cacaaaatcc acgatggggg tggtcatgct cattcgcagg
     1621 cttcgccgtc agcgcaggcg ttgcaggtag agcccagctc aataggcacc tcgatgccct
     1681 tggctgccag ttcctgattc tcggctacct tgatcataat ggcgcactcc atgcgctttt
     1741 tgaacagctc gcagccgtac tcgtacacgc cggtaatgct gccggtggcg tggtaggagt
     1801 tggcagcgca gccgccggag cagtacaact ttgcccagca atcctgacac tccttgcggg
     1861 cgtaggcgtt gcagtgcttg aactcatccc gcacagcggt gttggtaacg cccttccaga
     1921 tatcgcccag caggtacttg gggtcgccca cgaactggtg gcaggggtac agatcgcccc
     1981 agggggtaac agccatgtac tcggtgccgg agccgcagcc ggagatgcgc ttatagatgc
     2041 aggggccgcc ggtcaggtcg atcatgtagt ggtagaaggt aaagcctctg ccctcgcggt
     2101 cgcgcttgat catctccttg gcaaggatct cgtactgctc cttcaggatg ggcaggtcgg
     2161 cctcagtcag ggcgctgggg tcgctggggt cgcagaccac cggctccatg ctcagctcgg
     2221 taaagccgag gtctgccatg tggaagatat cgttggtaaa gtcggtgtta aagtgggtat
     2281 aggtgccgcg catatagtag ttcttgtcgc cgcgcttctt gacgaactcc tggaacttgg
     2341 gcacgatgcg gtcgtagctg ccgttgcctg cgcagtccac gcggaagcgg tcgttgacct
     2401 ccttgcggcc atccagactc agcaccacat tgtggcactc cttattgcag aagtcgatga
     2461 cgtcgtcatc aatgagcaca ccgttggtgg tcatggtaaa gcggaagttc ttgttatgga
     2521 tcttctcctg ctcgcggcag taggccacca gctttttgac catatcaaag ttcatcagcg
     2581 gctcgccgcc aaagaagtcc acttccagat tgcggcgggt gccgctgttc tcgatgagga
     2641 agtccatggc gcgcttgccc acctcaaagc tcatcagggc gcggtcgcca tggtagcgtc
     2701 cctgcgaggc aaagcagtaa gagcagctca ggttgcagct atgggcaacg tgcaggcaca
     2761 gcgcctttac cacagtgttg cggtttttaa agtcgaaggc catgtcctta tagacatccg
     2821 ggctccacag cttgccgttt tccttcaggc tggtcacgtc gtcgatgcac tggcgcagat
     2881 cctcctcggt cacgtccggg cggctgccgt actttgccag catggcggca acgatctcgt
     2941 ctgcggtatg ctccgggtac atggcgatga catcgtaggc cacctcgtcc acaacgtgca
     3001 ccgagccgct gcaggtgtcc agcacgatgt tataaccgtt caattgatac tgatgtacca
     3061 ttttacactc cattccagat tacacaaaaa aatgccgccc ggcaaaggcg gcatagggtt
     3121 tgcaaaaatt acttgttgct gttctcgcac tgctggttag ccacgccgca ggaggtcttg
     3181 caggcggact ggcaggaagt ctggcactcg ccgcagccac cggtcttaac gctcttggtc
     3241 aggtcacgag tagcaatagt cttaatacgc tccatgatag aaacctctct aactctcaaa
     3301 attttatcgc gccggacata gttccggtac gcttttatct tgtaatagga tatcacgcag
     3361 cgcgcctttt gtcaagattt tttcgctaag gcaataccgc ataattctag gtgccgatac
     3421 ggcgagtgag gtgcggcaga tgctaagcca aaagcgcaga taatactttg tgtattatcg
     3481 agcattttgg caacgcagat gccgtgccgc aaccgccgga gtggtgctta agccgtaagg
     3541 cgggaattgt gcggtgttgc cctaagcctt tttacccgcc catgggctgg tagcgggtaa
     3601 gcaccgtatg cagccccagc tcccgggcgc gcgccagtaa gtaccggtag cggcacaaaa
     3661 gcgcctgccg ctcgtagatg cgctgctcga tgaggtccgt atccacctcc atatcaaaca
     3721 tcatctcgtt gcgcttcaaa cagaacaggc attccttcag ttcctcctcc agctccgggt
     3781 ggtagcgctc gtgctcggta tcccgcggga cgcggggcga aagcagggtc tgggcgtttt
     3841 gtgtggttcg ttccggcata ggcatcctcc ttctggtact ttgcaaggtt ttgtaccttc
     3901 cagtataggc ggtgcggtgc gcagaacctg ccgaagtgtg gcagcgctcc ggcatagatt
     3961 atccggcgct gctgcggcat tttccaaaaa agtacaactt ttttcaaaaa tatgcttgac
     4021 aactccgggc ttttcccgta taatagcaca cgttgagcgg ctcaccccgc aaaacacaac
     4081 agaatattgg ggatttgcat agtggtagtg cggtagactc tgactctact tgtgggagtt
     4141 cgattctctc atccccaacc agattaaagc catctgaaga agttcaggtg gcttttctgt
     4201 ttatatcatt ccgaaccaca gccgcaaggc cgtgactctt caaaacttga agagtcataa
     4261 ctctattacc actttggatt tttgaagagt gacgaaaaag aagcgcatca gcgtttaaaa
     4321 gttcactctt caagatgaag agtcatggcc tgaaaacgca gttttctttg ctttttgttc
     4381 atgactcttc aaaacccctg tgggtcatag ggaacttttg aagagtcacc cctgccgggg
     4441 cgggacgatt tagaatgcgc tccgcgttcg ctctgcgcat aattagcgga attagttttt
     4501 tactcgagat tcagaaaagc ctgcgggctt ttctgaatct ccttttcacc agtggggtcg
     4561 taacggtcaa ctgcatttgc aattcagacc accatttaac cattgcagcc ctccccgtga
     4621 aaatgggata gcggagcgca tttccaatcg ttcgtactgc acaaaaaacc gggcagcccg
     4681 cagactgccc ggtttttgct atacagttga cctgccctga tagggctttc ttttacagaa
     4741 tggtgatgcg gcctgcgccg taaggctgct cgtagttgag caggtagccg gggtatgcgg
     4801 ccagcgggct gttggcgctg gacaggtgcg gcagacccgc agcatctgcg ccgtcaaaaa
     4861 tcatagcgta ggtagacatc accagataat cctcggacac atagtccttg atcagctctg
     4921 cgccgtcaaa catggcaaag ccgtcgccca gattgcgcag ggtgtagttc atgccggcca
     4981 gcgcgtaggt agcgcccggg tccagcggta gatagctgcc ggaagcctta tcgtagatct
     5041 tcacgttctg cacgcgcggg gtgccggtgg cgctgccgat ccagacgttc ttctcgtcgg
     5101 tctgcacagt gttggggata tcggtgtgga tctcgtaggt agcaccggcc acctgcagga
     5161 agccgccgtt ctccttgccg tcctcgcctg caaagcgagc tgcaaactcc aatgcgtcct
     5221 ggatctgctt gccggtgacc gacatcaggc aggccacgtt gccaaagggg ctgatctgct
     5281 tgcaggtctt gaaggtccag tcgcctgcag gcacatcggc gcggatgccg ccgccgttca
     5341 tgatggccac atcacagtgc agcttttcca cctcgttgaa gtaggtgtag atgccgtcag
     5401 ccacaaagtc gccgaggttg gtctcggcag agcggatgcg gcgcttgccg gtggcggggt
     5461 cagagacgta gaaatcgctg tcgcccacag cgatcttctc gcccagcata tcgtccacgg
     5521 tgttcaccca gctggtctgc atggcggcga tgcctgcgtc catgccctcg tgggtgggga
     5581 tgagcttggt ggtaatggtg ccgtccgcag cgatggtcat ctcgccaacg tttgcaaagt
     5641 aagagccggt ctgggtcagg gtgacagcct tgccggaagc atcctgcacc tgcttgttct
     5701 ccattacggt atgggagtgg ccgtcgataa aggcgtcaaa gccgctggtg tgggcaatga
     5761 cttcctcact agtccacgga gaggaagagg ggtctacgcc cagatggccc agaccgatga
     5821 ccacgtctgc cagaagcttt gccttatcaa tggccttctg cacggcgtca tagagctttt
     5881 tgccgtcctc gccgccctga atatcgtaga tgtacttgcg ctgtgcctta tccataaagt
     5941 aggccggggt ggacttggta aaggtttcgg gggtggtcac gcccacaaag gcaatgcgtc
     6001 tgccgccgcg cacgaacacc ttgacggagg gcagcacacg cagcgtagtg cgcaggtcta
     6061 cccagttgca ggacaggtac gggaaatcgg cttccttcat gatggccttg gcacggtcca
     6121 tgccgtagtc aaactcgtgg ttgccggggg tggcgacatc gtaaccggca gcgttcatca
     6181 gcttgatgat ggaggcaccc tcgtccatgg agccgtaggc agtgccctgc acatggtcgc
     6241 ctgcatccac cagcagcacg tccttaccgg cgttctgata gctctgcttc aggtcggcaa
     6301 tagcggcgta ggtcaacttg gggctctgct tgtcgatgta ggtatggaca tcgttggtgt
     6361 acaggatggt aacgtcagac ttgtcaccat accagcaggc cgatgcggca ggcgcaccga
     6421 tggccatgga tgcagcggca gcggtcacac cagcagcctt taaaaagctg cgacgggaaa
     6481 taagttgttt cacaggaaaa cgacctcctt ttatttttgg cgtatcgcat ttgaggcagg
     6541 ctcttccctc ctgccctttc aatagctcta gcatagcaca gaacgccgcc gcaaacaagc
     6601 caaaatcatt cttttggcac aaattatttt cacgctctgc tttattttga cgcatattgt
     6661 accattttta cacaaaaaag acctccccgt gccctgtcgc agagcagcgg agaggtcttt
     6721 tttagggggt gttgacccgt tgccgggtct atcggaggag agggaaatat cagatggcgt
     6781 tatactcctt gaggaacttc tcaaggtcgg taccctcgat cttcttcaaa gcttccttca
     6841 aagccagacg cgggatcagc ggcagatcca tgtcggtgat ctttttgccg tcgcgcagct
     6901 tcacggtggc atcgatcagg gcgcgcacat cgtaggtgct gccccagacc tcgggcacgc
     6961 cgcggtcgat gttcagcagg gtgtacacgg cctccatacc ggtgcgcatg gagtactcgg
     7021 tggtaaagat ggtatcgcgg gcggtctcgg caaactggcc aaggaaggca aagttcacag
     7081 caccctcggg cacaacatcg ggacggtcgc ccatggcacg gggcatgaag aaggcatcga
     7141 tatagggcat catcacaggc acggtgttgg cgctgtgctc tgccagttca gcgatctgat
     7201 cctcgggcac gccgatgtgg tacagccact ccatgcagat ctcgcggccg gtgcagtcac
     7261 gcatgggctt cttgacgtaa tcgccgggct tatcgctgaa caggccgtac acccagacgc
     7321 acagctggtt cttgggctga tccttgaact gctgctgacg gttcagcgtc cagctgagca
     7381 gccagctgga gtccttgacg gtaacgatgc cgccggtgac agtgtggccg ctgaaggggt
     7441 cgcgcttgca gatcttgcgg atatactggg ggatcttgtc gtccagcgtg gtgatggtag
     7501 cgctctccca gttgctcagc tccggctcgg agcagaactt ctccgggtga ccgaaagagg
     7561 gatcctgtgc ggcgatcttc ttccacagat cccagccgtt gccgggctgg atggtggggt
     7621 cgaaaccggt ggccttattc tgtgcgccca cggtgcagct ttccacgcag ccgccgttgg
     7681 tgatgaacag cagatcgttc tcggtcaggt cgatattgga agtctcgccc gcgtgctcca
     7741 cggtgacaga gcttgccagc ttgcggccct tctggatatc gaacttgaca tcggtgacct
     7801 tggtgttgta gtggaactgc acgccaaagc tttccagata gcgcaccatg ggcaggatga
     7861 tggactcgta ctggttatag cgggtaaagc gcagggcggt aaagtccggc agaccgccga
     7921 tgtggtggat atagcgcttg aggtacagct tcatttccaa agcgctgtgc cagttctcga
     7981 aggcgaacat ggtgcgccag tacatccaga agttggtgtt gagcacctcg tcatcgaaga
     8041 aatcggtgat ctttttatcc tgcagctgct cgtccggggt gaagaacagc ttcatgatct
     8101 ccatggcacc cttatcggac aggccgaact tgccatcggt gtgggcatcc tcgccgcggt
     8161 tgacggtggc acggcacaag gagaagttgg ggtcctcctt gttcagccag taatactcgt
     8221 ccagcacgct ggcaccctcg gtctccagag aagggatgga gtgcagcaga tcccacatga
     8281 cctcgaagtg gttgtccatc tcgcggccgc cgcgcatcac atagccgata tcgtacttgt
     8341 agccatcgca ggcaccgccc gccagtgcgt tcttttcaaa cacatggacg tgctcgccct
     8401 tcatctggcc atcgcgcacc agatagcagg cagcggtcag ggctgccaga ccggagccga
     8461 tgatataagc ggatttatga tccacaccct ccggcttttt gggggttgca aaagcttcgt
     8521 agttgccact ggaatagtac ataaaaaagc ctccctgctt cagcgtttta ttttcacagc
     8581 cttcatcgtg ctgttctcta tggcaacagt ataccccgca aagtgaactt gaacaacaaa
     8641 caaactttgc ccggtgtata gattttttac atccgccctt atttgctgga aatgcgtaca
     8701 aattgtgaca taaaagcgat atgcaaaatc tttcagctta gtcgttgcct tgctcttgcc
     8761 attttcagcg ggctcgccct ctcagtcatc gctgcgcgat gccagctccc ccaaagtggg
     8821 agcccttggc agtccacgca aagttcatct ctttgccaag gcctctccct ttgggagagg
     8881 tggatttgcg aagcaaagac ggagagggcg aggatgctcc ccatgtacaa caaaaagaga
     8941 gccgccgcac aaaggtctgt gcagcggctc tctatcggtt ttagttcatc tcttccagag
     9001 cctttttcag gttctttgcg atctggtccg ggcagctggt gctgcggaag ccgcacagcg
     9061 tgccatccag acgggcaatg gcgtcctctg ccttcatgcc ggtgagcagc tggcagatgc
     9121 ctttcaggtt gccgttgcag ccgccgatga cctcgatgga tgcaatggtg tggtcatcgt
     9181 tcagcacaaa gttggtctgc ttagagcagg tgcccttgtt cgggaaggaa aattccttgc
     9241 tcatggtctt tacgtcctct ctcttttacg tttttcggcg atgacgcgca gctgcgctgc
     9301 ggcttcgtcc ggtgcggtac aggtaccgat ggggtggggg tgcttgtggt tgcggccatg
     9361 gaagtccgtg cccgcagtgg ccacaaggcc gtactgcttg cacagggcaa ggcactcggc
     9421 gctgtcctcc gggctgttgc tggggtggta cacctctatg ccgtccactg cgccctctgc
     9481 caccagctcg cgcagcaggg gcatactttt gtacaccgtg gggtgggcaa acaccaccgc
     9541 gccgccgctg gctttagcgg tagccagcac ctgccgcacc ggcagatact ccggcgagtg
     9601 cagtacgatg ccccgggggt tccacccgaa cagcttgtgg taggtctcgc cgtagatgct
     9661 gccatcggtc aggcccagca gttccagcgc ctgcatcagc ccgcttttga acagcacccc
     9721 gctggccttt gtggtctccc atgcaaggtc ggtggtaaac tgcgggtaca gctgctccag
     9781 ctcctttgcg ctctgcaaag cgcaggcgtt gcggcgctcc ttcataatgg cgcagtgctc
     9841 ccgcagcgcc gggcagtcca cgtccgggta gtagcacagc aggtgcaccc ggtgctggcg
     9901 ctcaaagtcg tagccggtca gctccacggc ggggatcagc tctaccccgt cctgcccggt
     9961 gtgggcatag gcgtactggg cgctgagcag ggtgtcgtgg tccgaaaggg cgatggcgtg
    10021 cagcccggtg cgggcggcga tggacgccag ccgctcgatg ggcacagcac cgtcggagca
    10081 ggtggaatgg atatgcaggt cacaggacat agcgggttac ttccttagtg cttatagaaa
    10141 ttgatcaggc agccgtcggc caggatctgg cgctcgtcgg tggtgagcgg agccatgtac
    10201 agctcaaact ccttgacggt atcgcccaga acataggcct tgatgttctg caggtcgccc
    10261 ttgagtgctt cccgcacatt ggggatgagc acatagtccc ccagaccaaa gggggtggcg
    10321 cctgccagct gcaggggcag catgccccag ttgatgaggt tggagcggta acgcttggtg
    10381 gcgtactcgg ttacgatatt ggcaccggca cccagcacac gctggcagct ggcggcctgc
    10441 tcacgggcag agccgtcgcc gggcttgacc gcaaagatgg tagaggcgat ctggatatcg
    10501 ttccagctca gctgttcgca gccgggcacg gcgttcacct ttgccagcag ggcggcgtcc
    10561 cctgcaccgg cgcggcgggc agcttcctcg gcctgcacgg ccttggcgcg actcacatac
    10621 tccgggtcct tgcggctgag ggtgaactca gccagaccca gcggattgga acggtaagag
    10681 gacgtctcgc cggaggggat cagctcgtcg gtggtggtga cggggtcggt gatataagaa
    10741 accaccttca gcagcaggtt gtcgcccagt ggtgcgattt ccggccagtc cttgatgttg
    10801 gggccaaact tgagcagggc atcgtaatcg cctttgccga agccctgata cacgcgggtg
    10861 tcgtagctgg aagcatcgta ctggtactcc ggcacggtgg gatcataatc aatgtcggtg
    10921 gcgggggtca ggatgccgcc gtttgcggtg gtggctgcaa tgctgcgggc atccatcagt
    10981 gccacaccgg ccagctggcc gctgccgggc ttggagccct cgcggctggg gaagttgcgg
    11041 gtggtgtgac ggatggacag tgcaccgttg gcgggcacat cgcctgcgcc gaagcagggg
    11101 ccgcagaagg cggtgcggat ggtagcgccg ctggccatca gctcgccgat gacgccggtg
    11161 cgcaccagtt ccatcatgat gggctgactg ccggggtaaa cgctcaaggc gtagtcgccg
    11221 cagccgccgg tatgaccctt gaggatggaa gccgcctcgt agatgctgtc gtacagaccg
    11281 cctgcgcagc ctgcaatgac gccctgatcc acacgcagct tgccgttttc gatcttgctg
    11341 cacagatcca gctgcacatc cttgcggccg atcagcttct gcacatcctg ctcgcaggcg
    11401 tggagaatgt cctccagatt tgcgttcagt tcctcgatgg taaaggcatt ggaggggtgc
    11461 atgggcaggg cgatcatggg acggatggca gaaagatcca cctccaccac accatcgtag
    11521 taggcaaggt ctgccggtgc aagtttttta tagtctgctg cacggccatg cactgccaga
    11581 aaacgctggg tgacttcgtc ggtctcccag atggaggaca gacaggtggt ctcggtggtc
    11641 atggcatcaa tggcgttgcg ggtatcctgc cgcagggaag caatgccggg gcccacgaac
    11701 tccatgacct tgttcttgac gtagccgctc ttgaacagct tgcccacaag ggcaatagct
    11761 acatcgtggg ggccgcagcc cgccggcaga ctgccggtca ggtagatagc caccacaccc
    11821 gggcgggcaa catcataggt gcggcccagc agctgctttg ccagctcgcc gccgccctcg
    11881 ccgatggcca tggtgcccag tgcgccgtag cgggtgtggg agtccgagcc aaggatcatt
    11941 ttgccgcagc ccgcaaagcg ctcgcgcata tactggtgga tgactgccat gtgcgggggc
    12001 acaaagatgc cgccgtactt tttggcggcg gacaggccaa agcggtggtc gtcctcgttg
    12061 atggtgccgc ccacagcgca caggctgttg tggcagttgg taagcacata aggaatgggg
    12121 aacttttcca gcccggaagc acgggcggtc tggatgatgc ccacaaaggt gatgtcatgg
    12181 cttgccatgg catcaaactt gatcttcagg ttctcggcat cgccgctggt gttgtgtgcc
    12241 tgcataatat tgtaggccat ggtaccggtc ttagccgcgg caacggcagc ggcatcaaag
    12301 ccctttgctg ccagcgctgc gggtgcattg ccatctgcgg gcacccactc tccgcgcgca
    12361 tagtacgcac cgccagtgct gcatttgatc atatccaaca tctcgattcg cctctctttt
    12421 tgtattttcc cgcccgccgc aattgcgggc attgccccgg cagtgcggct attcatcccg
    12481 aaaacagccg tccccttagc cttcacccct tgggggaagg tggcgcacag caccggatga
    12541 ggggtatttc ttggcaacag caccctcatc agtcgcctgc ggcgacagct tttcaaagac
    12601 ttataacccc tgccctgtta cggcaaaagc cgtatttaac ttttattata gcatgaaagg
    12661 gcgaaaagaa aaagcatttt ttatgaaccc ttactgcacc tttgcggcgg cttcctgctg
    12721 cttttccttt tgcagtttac ggaacaccac aaaataggcc gggatcagga agaagcaggc
    12781 aaagagccat gccaccgggc ttgcgatgca ggcggcaaag tagccccaca gcggcacgaa
    12841 ccagaagccc accatggcgc gggcgatcat ctcggccaca ccggcaaaca tggcaaggcc
    12901 ggagtgaccc agaccctgaa tggtgtagcg gtagatgata agcactgcca gcgggatgta
    12961 gaacacgctg ttccagaaga tgaactcctg cgcattggcc ataatggcgg tctcgcctgc
    13021 gtccaggaac aggccgatca ggggcttgtc cagcacgcgc aggatgagga aagaggccac
    13081 gctgtacacg cagccgatgc ccagtgcggt gttcacgccg cggttcacgc ggcccagatc
    13141 cttcgcgccc atattctggc tggtgtaggt ggtcatggcg gtgccgatgc tctccagcgg
    13201 cacgctgagg aactgcgcag ccttgccgcc ggcggtctgc gcggctacga tatcgctgcc
    13261 cagaccgttc accgcgccct gcagcaccac gctgccgatg gcagtaatac tgcactgcag
    13321 acccatgggg aggcccatgg cgcaaagctt tgcgca
//
