LOCUS gnlProkkaKIBFGNFI_108 13356 bp DNA linear UNK 01-JAN-1980 DEFINITION gnl|Prokka|KIBFGNFI_108. ACCESSION gnlProkkaKIBFGNFI_108 VERSION gnlProkkaKIBFGNFI_108 KEYWORDS . SOURCE ORGANISM . COMMENT ##antiSMASH-Data-START## Version :: 7.1.0 Run date :: 2024-11-17 20:19:26 Original ID :: gnl|Prokka|KIBFGNFI_108 NOTE: This is a single region extracted from a larger record! Orig. start :: 0 Orig. end :: 13356 ##antiSMASH-Data-END## FEATURES Location/Qualifiers protocluster 1..13356 /aStool="rule-based-clusters" /category="RiPP" /contig_edge="True" /core_location="[1609:3356]" /cutoff="20000" /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or (YcaO or TIGR03604))))" /neighbourhood="10000" /product="ranthipeptide" /protocluster_number="1" /tool="antismash" proto_core 1610..3356 /aStool="rule-based-clusters" /tool="antismash" /cutoff="20000" /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or (YcaO or TIGR03604))))" /neighbourhood="10000" /product="ranthipeptide" /protocluster_number="1" cand_cluster 1..13356 /candidate_cluster_number="1" /contig_edge="True" /detection_rules="(TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or (YcaO or TIGR03604))))" /kind="single" /product="ranthipeptide" /protoclusters="1" /tool="antismash" region 1..13356 /candidate_cluster_numbers="1" /contig_edge="True" /product="ranthipeptide" /region_number="1" /rules="(TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or (YcaO or TIGR03604))))" /tool="antismash" CDS 2..145 /locus_tag="ctg108_1" /transl_table=11 /translation="MINLPVPRMWLANPHSILRGGFSLSRAKAVFIPPAKLVVVARSSY PI" CDS complement(195..1613) /locus_tag="ctg108_2" /transl_table=11 /translation="MSMTTPIVDFVRSYAKSGTARLHMPGHKGQSLLGFEPLDITEICG ADELYAPEGIIAESEANATRLFGTAHSYYSTEGSSQCIRAMLFLALQGAPQNGKRPVLL AARNAHKALLYAAALLDFDIRWLWPSAQAEGALCSCPVTAEALTGALHAMAQQGNTPFG VYVTSPDYLGGVQELPALAAVCRAQDVPLLVDNAHGAYLRFLPQNCHPIAQGAAMCCDS AHKTLPVVTGGAYLHLAHDAPVQDEAAVRGALALFGSTSPSYLILQSLDACNAVLAGDY PRRLVQCCAALEGLRRSLNKAAAARQCPVPLAVAGAQQEPMKLTLDAAALGCTGTALAD ALRRAQLECEYADPRYVVLMFTPENPPQDFERLQTALEQLLAAVPAGLSRPENRAGEFA ALQQQAVQRCTIRQAVLGAQVRVPVHKALGRVCAMPTVSCPPAIPVAVSGEEITPAAIA LMQRYGIKELSVLR" CDS complement(1610..3061) /gene_functions="biosynthetic (rule-based-clusters) ranthipeptide: TIGR04085" /gene_functions="biosynthetic (rule-based-clusters) ranthipeptide: Ranthipeptide_rSAM_RRE" /gene_functions="biosynthetic (rule-based-clusters) ranthipeptide: PF04055" /gene_functions="biosynthetic-additional (rule-based-clusters) Fer4_12" /gene_kind="biosynthetic" /locus_tag="ctg108_3" /sec_met_domain="Ranthipeptide_rSAM_RRE (E-value: 8.5e-31, bitscore: 97.0, seeds: 20, tool: rule-based-clusters)" /sec_met_domain="Fer4_12 (E-value: 1.4e-15, bitscore: 48.6, seeds: 84, tool: rule-based-clusters)" /sec_met_domain="PF04055 (E-value: 1.1e-16, bitscore: 52.5, seeds: 518, tool: rule-based-clusters)" /sec_met_domain="TIGR04085 (E-value: 2.3e-20, bitscore: 63.6, seeds: 281, tool: rule-based-clusters)" /transl_table=11 /translation="MVHQYQLNGYNIVLDTCSGSVHVVDEVAYDVIAMYPEHTADEIVA AMLAKYGSRPDVTEEDLRQCIDDVTSLKENGKLWSPDVYKDMAFDFKNRNTVVKALCLH VAHSCNLSCSYCFASQGRYHGDRALMSFEVGKRAMDFLIENSGTRRNLEVDFFGGEPLM NFDMVKKLVAYCREQEKIHNKNFRFTMTTNGVLIDDDVIDFCNKECHNVVLSLDGRKEV NDRFRVDCAGNGSYDRIVPKFQEFVKKRGDKNYYMRGTYTHFNTDFTNDIFHMADLGFT ELSMEPVVCDPSDPSALTEADLPILKEQYEILAKEMIKRDREGRGFTFYHYMIDLTGGP CIYKRISGCGSGTEYMAVTPWGDLYPCHQFVGDPKYLLGDIWKGVTNTAVRDEFKHCNA YARKECQDCWAKLYCSGGCAANSYHATGSITGVYEYGCELFKKRMECAIMIKVAENQEL AAKGIEVPIELGSTCNACADGEACE" CDS complement(3129..3356) /gene_functions="biosynthetic (rule-based-clusters) ranthipeptide: SCIFF" /gene_functions="biosynthetic (rule-based-clusters) ranthipeptide: TIGR03973" /gene_kind="biosynthetic" /locus_tag="ctg108_4" /sec_met_domain="TIGR03973 (E-value: 1.1e-25, bitscore: 80.1, seeds: 29, tool: rule-based-clusters)" /sec_met_domain="SCIFF (E-value: 6.2e-25, bitscore: 77.7, seeds: 37, tool: rule-based-clusters)" /transl_table=11 /translation="MISYYKIKAYRNYVRRDKILRVREVSIMERIKTIATRDLTKSVKT GGCGECQTSCQSACKTSCGVANQQCENSNK" CDS 3468..3593 /locus_tag="ctg108_5" /transl_table=11 /translation="MCIIEHFGNADAVPQPPEWCLSRKAGIVRCCPKPFYPPMGW" CDS complement(3572..3739) /locus_tag="ctg108_6" /transl_table=11 /translation="MKRNEMMFDMEVDTDLIEQRIYERQALLCRYRYLLARARELGLHT VLTRYQPMGG" CDS complement(3714..4049) /locus_tag="ctg108_7" /transl_table=11 /translation="MLLYGKSPELSSIFLKKVVLFWKMPQQRRIIYAGALPHFGRFCAP HRLYWKVQNLAKYQKEDAYAGTNHTKRPDPAFAPRPAGYRARALPPGAGGGTEGMPVLF EAQRDDV" CDS complement(4184..4333) /locus_tag="ctg108_8" /transl_table=11 /translation="MKSELLNADALLFRHSSKIQSGNRVMTLQVLKSHGLAAVVRNDIN RKAT" CDS 4455..4631 /locus_tag="ctg108_9" /transl_table=11 /translation="MRSAFALRIISGISFLLEIQKSLRAFLNLLFTSGVVTVNCICNSD HHLTIAALPVKMG" CDS complement(4733..6427) /gene_functions="biosynthetic-additional (smcogs) SMCOG1283:2`,3`-cyclic-nucleotide 2`-phosphodiesterase (Score: 252; E-value: 2.1e-76)" /gene_kind="biosynthetic-additional" /locus_tag="ctg108_10" /transl_table=11 /translation="MAIGAPAASACWYGDKSDVTILYTNDVHTYIDKQSPKLTYAAIAD LKQSYQNAGKDVLLVDAGDHVQGTAYGSMDEGASIIKLMNAAGYDVATPGNHEFDYGMD RAKAIMKEADFPYLSCNWVDLRTTLRVLPSVKVFVRGGRRIAFVGVTTPETFTKSTPAY FMDKAQRKYIYDIQGGEDGKKLYDAVQKAIDKAKLLADVVIGLGHLGVDPSSSPWTSEE VIAHTSGFDAFIDGHSHTVMENKQVQDASGKAVTLTQTGSYFANVGEMTIAADGTITTK LIPTHEGMDAGIAAMQTSWVNTVDDMLGEKIAVGDSDFYVSDPATGKRRIRSAETNLGD FVADGIYTYFNEVEKLHCDVAIMNGGGIRADVPAGDWTFKTCKQISPFGNVACLMSVTG KQIQDALEFAARFAGEDGKENGGFLQVAGATYEIHTDIPNTVQTDEKNVWIGSATGTPR VQNVKIYDKASGSYLPLDPGATYALAGMNYTLRNLGDGFAMFDGAELIKDYVSEDYLVM STYAMIFDGADAAGLPHLSSANSPLAAYPGYLLNYEQPYGAGRITIL" CDS complement(6384..6530) /locus_tag="ctg108_11" /transl_table=11 /translation="MRYAKNKRRSFSCETTYFPSQLFKGCWCDRCRCIHGHRCACRIGL LVW" CDS complement(6568..6804) /locus_tag="ctg108_12" /transl_table=11 /translation="MRSSSRSITPSDISLSSDRPGNGSTPPKKDLSAALRQGTGRSFLC KNGTICVKIKQSVKIICAKRMILACLRRRSVLC" CDS complement(6770..8701) /locus_tag="ctg108_13" /transl_table=11 /translation="MYAFPANKGGCKKSIHRAKFVCCSSSLCGVYCCHREQHDEGCENK TLKQGGFFMYYSSGNYEAFATPKKPEGVDHKSAYIIGSGLAALTAACYLVRDGQMKGEH VHVFEKNALAGGACDGYKYDIGYVMRGGREMDNHFEVMWDLLHSIPSLETEGASVLDEY YWLNKEDPNFSLCRATVNRGEDAHTDGKFGLSDKGAMEIMKLFFTPDEQLQDKKITDFF DDEVLNTNFWMYWRTMFAFENWHSALEMKLYLKRYIHHIGGLPDFTALRFTRYNQYESI ILPMVRYLESFGVQFHYNTKVTDVKFDIQKGRKLASSVTVEHAGETSNIDLTENDLLFI TNGGCVESCTVGAQNKATGFDPTIQPGNGWDLWKKIAAQDPSFGHPEKFCSEPELSNWE SATITTLDDKIPQYIRKICKRDPFSGHTVTGGIVTVKDSSWLLSWTLNRQQQFKDQPKN QLCVWVYGLFSDKPGDYVKKPMRDCTGREICMEWLYHIGVPEDQIAELAEHSANTVPVM MPYIDAFFMPRAMGDRPDVVPEGAVNFAFLGQFAETARDTIFTTEYSMRTGMEAVYTLL NIDRGVPEVWGSTYDVRALIDATVKLRDGKKITDMDLPLIPRLALKEALKKIEGTDLEK FLKEYNAI" CDS complement(8981..9244) /locus_tag="ctg108_14" /transl_table=11 /translation="MSKEFSFPNKGTCSKQTNFVLNDDHTIASIEVIGGCNGNLKGICQ LLTGMKAEDAIARLDGTLCGFRSTSCPDQIAKNLKKALEEMN" CDS complement(9250..10110) /locus_tag="ctg108_15" /transl_table=11 /translation="MSCDLHIHSTCSDGAVPIERLASIAARTGLHAIALSDHDTLLSAQ YAYAHTGQDGVELIPAVELTGYDFERQHRVHLLCYYPDVDCPALREHCAIMKERRNACA LQSAKELEQLYPQFTTDLAWETTKASGVLFKSGLMQALELLGLTDGSIYGETYHKLFGW NPRGIVLHSPEYLPVRQVLATAKASGGAVVFAHPTVYKSMPLLRELVAEGAVDGIEVYH PSNSPEDSAECLALCKQYGLVATAGTDFHGRNHKHPHPIGTCTAPDEAAAQLRVIAEKR KRERT" CDS complement(10125..12569) /locus_tag="ctg108_16" /transl_table=11 /translation="MRVLLPRNTPHPVLCATFPQGVKAKGTAVFGMNSRTAGAMPAIAA GGKIQKERRIEMLDMIKCSTGGAYYARGEWVPADGNAPAALAAKGFDAAAVAAAKTGTM AYNIMQAHNTSGDAENLKIKFDAMASHDITFVGIIQTARASGLEKFPIPYVLTNCHNSL CAVGGTINEDDHRFGLSAAKKYGGIFVPPHMAVIHQYMRERFAGCGKMILGSDSHTRYG ALGTMAIGEGGGELAKQLLGRTYDVARPGVVAIYLTGSLPAGCGPHDVAIALVGKLFKS GYVKNKVMEFVGPGIASLRQDTRNAIDAMTTETTCLSSIWETDEVTQRFLAVHGRAADY KKLAPADLAYYDGVVEVDLSAIRPMIALPMHPSNAFTIEELNANLEDILHACEQDVQKL IGRKDVQLDLCSKIENGKLRVDQGVIAGCAGGLYDSIYEAASILKGHTGGCGDYALSVY PGSQPIMMELVRTGVIGELMASGATIRTAFCGPCFGAGDVPANGALSIRHTTRNFPSRE GSKPGSGQLAGVALMDARSIAATTANGGILTPATDIDYDPTVPEYQYDASSYDTRVYQG FGKGDYDALLKFGPNIKDWPEIAPLGDNLLLKVVSYITDPVTTTDELIPSGETSSYRSN PLGLAEFTLSRKDPEYVSRAKAVQAEEAARRAGAGDAALLAKVNAVPGCEQLSWNDIQI ASTIFAVKPGDGSAREQAASCQRVLGAGANIVTEYATKRYRSNLINWGMLPLQLAGATP FGLGDYVLIPNVREALKGDLQNIKAYVLGDTVKEFELYMAPLTTDERQILADGCLINFY KH" ORIGIN 1 aaagataaac ctccctgttc ctagaatgtg gttggcaaac ccacactcta ttctacgggg 61 aggtttctct ttgtctaggg ctaaagccgt ttttattcca ccagcaaagc tggtggttgt 121 cgctcgctca agctacccaa tatagagaac ccggaaggtc cgcagacctt ccgggttctc 181 ttcttataaa atctttatcg cagcaccgag agttctttga tgccgtagcg ctgcatcagg 241 gcgatggctg ccggggtgat ctcctcgccg ctgaccgcca cagggatggc gggcgggcag 301 gacaccgtag gcatggcaca cacccgtccc agtgccttgt gcaccgggac gcgcacctgt 361 gcacccagca ccgcctgccg gatggtacag cgctgcaccg cctgctgctg caaggcggca 421 aactctcctg cccggttctc ggggcgggac agtccggcag gcacagcagc cagaagctgt 481 tccagcgccg tttgcaggcg ttcaaagtcc tgcggcgggt tttccggggt gaacatcagc 541 accacatagc gggggtcggc atactcgcac tccagctgtg cgcggcgcaa agcatctgcc 601 agcgctgtgc cggtgcagcc aagggcggcg gcgtccagcg taagcttcat cggctcctgc 661 tgtgccccgg caactgccag cggcaccggg cactgccgcg ccgctgcggc cttattcagg 721 ctgcggcgca gaccttccag cgccgcgcag cactgcacca gccgccgggg gtagtcccct 781 gccagcaccg cattgcaggc atccagcgac tgcaaaatga ggtaagaggg gctggtagag 841 ccgaacagcg ccagcgcccc ccgcacagcc gcttcgtcct gcacaggggc atcgtgcgcc 901 agatgcagat acgcaccgcc ggtgaccacc ggcagagtct tgtgggcaga gtcgcagcac 961 atggccgcgc cctgtgcgat ggggtggcag ttctgcggca gaaagcgcag gtaggccccg 1021 tgggcgttat ccaccagcaa aggcacgtcc tgcgcccggc agacagcggc cagcgccggg 1081 agttcctgca ccccgcccag ataatccggg ctggtgacgt acacgccaaa gggggtgttg 1141 ccctgctgtg ccatcgcgtg caaagcccct gtcagcgctt cggctgtgac ggggcagctg 1201 cacagtgcac cctctgcctg cgcagacggc cagagccagc ggatatcaaa atccagcagc 1261 gccgccgcat acagcagcgc cttgtgggcg ttgcgggcgg ccagcagcac cgggcgctta 1321 ccgttttgcg gtgcgccttg cagcgccaga aacagcatgg cacggatgca ctgagacgac 1381 ccctcggtgc tgtaatagct gtgcgccgtg ccgaacagcc gggtggcgtt ggcttcactc 1441 tcggcaataa tgccctccgg cgcgtaaagc tcgtccgcac cgcagatctc ggtgatatcc 1501 agcggctcaa agcctaaaag gctctgcccc ttgtggccgg gcatatgcag ccgggcggta 1561 ccggactttg catagctgcg cacaaaatcc acgatggggg tggtcatgct cattcgcagg 1621 cttcgccgtc agcgcaggcg ttgcaggtag agcccagctc aataggcacc tcgatgccct 1681 tggctgccag ttcctgattc tcggctacct tgatcataat ggcgcactcc atgcgctttt 1741 tgaacagctc gcagccgtac tcgtacacgc cggtaatgct gccggtggcg tggtaggagt 1801 tggcagcgca gccgccggag cagtacaact ttgcccagca atcctgacac tccttgcggg 1861 cgtaggcgtt gcagtgcttg aactcatccc gcacagcggt gttggtaacg cccttccaga 1921 tatcgcccag caggtacttg gggtcgccca cgaactggtg gcaggggtac agatcgcccc 1981 agggggtaac agccatgtac tcggtgccgg agccgcagcc ggagatgcgc ttatagatgc 2041 aggggccgcc ggtcaggtcg atcatgtagt ggtagaaggt aaagcctctg ccctcgcggt 2101 cgcgcttgat catctccttg gcaaggatct cgtactgctc cttcaggatg ggcaggtcgg 2161 cctcagtcag ggcgctgggg tcgctggggt cgcagaccac cggctccatg ctcagctcgg 2221 taaagccgag gtctgccatg tggaagatat cgttggtaaa gtcggtgtta aagtgggtat 2281 aggtgccgcg catatagtag ttcttgtcgc cgcgcttctt gacgaactcc tggaacttgg 2341 gcacgatgcg gtcgtagctg ccgttgcctg cgcagtccac gcggaagcgg tcgttgacct 2401 ccttgcggcc atccagactc agcaccacat tgtggcactc cttattgcag aagtcgatga 2461 cgtcgtcatc aatgagcaca ccgttggtgg tcatggtaaa gcggaagttc ttgttatgga 2521 tcttctcctg ctcgcggcag taggccacca gctttttgac catatcaaag ttcatcagcg 2581 gctcgccgcc aaagaagtcc acttccagat tgcggcgggt gccgctgttc tcgatgagga 2641 agtccatggc gcgcttgccc acctcaaagc tcatcagggc gcggtcgcca tggtagcgtc 2701 cctgcgaggc aaagcagtaa gagcagctca ggttgcagct atgggcaacg tgcaggcaca 2761 gcgcctttac cacagtgttg cggtttttaa agtcgaaggc catgtcctta tagacatccg 2821 ggctccacag cttgccgttt tccttcaggc tggtcacgtc gtcgatgcac tggcgcagat 2881 cctcctcggt cacgtccggg cggctgccgt actttgccag catggcggca acgatctcgt 2941 ctgcggtatg ctccgggtac atggcgatga catcgtaggc cacctcgtcc acaacgtgca 3001 ccgagccgct gcaggtgtcc agcacgatgt tataaccgtt caattgatac tgatgtacca 3061 ttttacactc cattccagat tacacaaaaa aatgccgccc ggcaaaggcg gcatagggtt 3121 tgcaaaaatt acttgttgct gttctcgcac tgctggttag ccacgccgca ggaggtcttg 3181 caggcggact ggcaggaagt ctggcactcg ccgcagccac cggtcttaac gctcttggtc 3241 aggtcacgag tagcaatagt cttaatacgc tccatgatag aaacctctct aactctcaaa 3301 attttatcgc gccggacata gttccggtac gcttttatct tgtaatagga tatcacgcag 3361 cgcgcctttt gtcaagattt tttcgctaag gcaataccgc ataattctag gtgccgatac 3421 ggcgagtgag gtgcggcaga tgctaagcca aaagcgcaga taatactttg tgtattatcg 3481 agcattttgg caacgcagat gccgtgccgc aaccgccgga gtggtgctta agccgtaagg 3541 cgggaattgt gcggtgttgc cctaagcctt tttacccgcc catgggctgg tagcgggtaa 3601 gcaccgtatg cagccccagc tcccgggcgc gcgccagtaa gtaccggtag cggcacaaaa 3661 gcgcctgccg ctcgtagatg cgctgctcga tgaggtccgt atccacctcc atatcaaaca 3721 tcatctcgtt gcgcttcaaa cagaacaggc attccttcag ttcctcctcc agctccgggt 3781 ggtagcgctc gtgctcggta tcccgcggga cgcggggcga aagcagggtc tgggcgtttt 3841 gtgtggttcg ttccggcata ggcatcctcc ttctggtact ttgcaaggtt ttgtaccttc 3901 cagtataggc ggtgcggtgc gcagaacctg ccgaagtgtg gcagcgctcc ggcatagatt 3961 atccggcgct gctgcggcat tttccaaaaa agtacaactt ttttcaaaaa tatgcttgac 4021 aactccgggc ttttcccgta taatagcaca cgttgagcgg ctcaccccgc aaaacacaac 4081 agaatattgg ggatttgcat agtggtagtg cggtagactc tgactctact tgtgggagtt 4141 cgattctctc atccccaacc agattaaagc catctgaaga agttcaggtg gcttttctgt 4201 ttatatcatt ccgaaccaca gccgcaaggc cgtgactctt caaaacttga agagtcataa 4261 ctctattacc actttggatt tttgaagagt gacgaaaaag aagcgcatca gcgtttaaaa 4321 gttcactctt caagatgaag agtcatggcc tgaaaacgca gttttctttg ctttttgttc 4381 atgactcttc aaaacccctg tgggtcatag ggaacttttg aagagtcacc cctgccgggg 4441 cgggacgatt tagaatgcgc tccgcgttcg ctctgcgcat aattagcgga attagttttt 4501 tactcgagat tcagaaaagc ctgcgggctt ttctgaatct ccttttcacc agtggggtcg 4561 taacggtcaa ctgcatttgc aattcagacc accatttaac cattgcagcc ctccccgtga 4621 aaatgggata gcggagcgca tttccaatcg ttcgtactgc acaaaaaacc gggcagcccg 4681 cagactgccc ggtttttgct atacagttga cctgccctga tagggctttc ttttacagaa 4741 tggtgatgcg gcctgcgccg taaggctgct cgtagttgag caggtagccg gggtatgcgg 4801 ccagcgggct gttggcgctg gacaggtgcg gcagacccgc agcatctgcg ccgtcaaaaa 4861 tcatagcgta ggtagacatc accagataat cctcggacac atagtccttg atcagctctg 4921 cgccgtcaaa catggcaaag ccgtcgccca gattgcgcag ggtgtagttc atgccggcca 4981 gcgcgtaggt agcgcccggg tccagcggta gatagctgcc ggaagcctta tcgtagatct 5041 tcacgttctg cacgcgcggg gtgccggtgg cgctgccgat ccagacgttc ttctcgtcgg 5101 tctgcacagt gttggggata tcggtgtgga tctcgtaggt agcaccggcc acctgcagga 5161 agccgccgtt ctccttgccg tcctcgcctg caaagcgagc tgcaaactcc aatgcgtcct 5221 ggatctgctt gccggtgacc gacatcaggc aggccacgtt gccaaagggg ctgatctgct 5281 tgcaggtctt gaaggtccag tcgcctgcag gcacatcggc gcggatgccg ccgccgttca 5341 tgatggccac atcacagtgc agcttttcca cctcgttgaa gtaggtgtag atgccgtcag 5401 ccacaaagtc gccgaggttg gtctcggcag agcggatgcg gcgcttgccg gtggcggggt 5461 cagagacgta gaaatcgctg tcgcccacag cgatcttctc gcccagcata tcgtccacgg 5521 tgttcaccca gctggtctgc atggcggcga tgcctgcgtc catgccctcg tgggtgggga 5581 tgagcttggt ggtaatggtg ccgtccgcag cgatggtcat ctcgccaacg tttgcaaagt 5641 aagagccggt ctgggtcagg gtgacagcct tgccggaagc atcctgcacc tgcttgttct 5701 ccattacggt atgggagtgg ccgtcgataa aggcgtcaaa gccgctggtg tgggcaatga 5761 cttcctcact agtccacgga gaggaagagg ggtctacgcc cagatggccc agaccgatga 5821 ccacgtctgc cagaagcttt gccttatcaa tggccttctg cacggcgtca tagagctttt 5881 tgccgtcctc gccgccctga atatcgtaga tgtacttgcg ctgtgcctta tccataaagt 5941 aggccggggt ggacttggta aaggtttcgg gggtggtcac gcccacaaag gcaatgcgtc 6001 tgccgccgcg cacgaacacc ttgacggagg gcagcacacg cagcgtagtg cgcaggtcta 6061 cccagttgca ggacaggtac gggaaatcgg cttccttcat gatggccttg gcacggtcca 6121 tgccgtagtc aaactcgtgg ttgccggggg tggcgacatc gtaaccggca gcgttcatca 6181 gcttgatgat ggaggcaccc tcgtccatgg agccgtaggc agtgccctgc acatggtcgc 6241 ctgcatccac cagcagcacg tccttaccgg cgttctgata gctctgcttc aggtcggcaa 6301 tagcggcgta ggtcaacttg gggctctgct tgtcgatgta ggtatggaca tcgttggtgt 6361 acaggatggt aacgtcagac ttgtcaccat accagcaggc cgatgcggca ggcgcaccga 6421 tggccatgga tgcagcggca gcggtcacac cagcagcctt taaaaagctg cgacgggaaa 6481 taagttgttt cacaggaaaa cgacctcctt ttatttttgg cgtatcgcat ttgaggcagg 6541 ctcttccctc ctgccctttc aatagctcta gcatagcaca gaacgccgcc gcaaacaagc 6601 caaaatcatt cttttggcac aaattatttt cacgctctgc tttattttga cgcatattgt 6661 accattttta cacaaaaaag acctccccgt gccctgtcgc agagcagcgg agaggtcttt 6721 tttagggggt gttgacccgt tgccgggtct atcggaggag agggaaatat cagatggcgt 6781 tatactcctt gaggaacttc tcaaggtcgg taccctcgat cttcttcaaa gcttccttca 6841 aagccagacg cgggatcagc ggcagatcca tgtcggtgat ctttttgccg tcgcgcagct 6901 tcacggtggc atcgatcagg gcgcgcacat cgtaggtgct gccccagacc tcgggcacgc 6961 cgcggtcgat gttcagcagg gtgtacacgg cctccatacc ggtgcgcatg gagtactcgg 7021 tggtaaagat ggtatcgcgg gcggtctcgg caaactggcc aaggaaggca aagttcacag 7081 caccctcggg cacaacatcg ggacggtcgc ccatggcacg gggcatgaag aaggcatcga 7141 tatagggcat catcacaggc acggtgttgg cgctgtgctc tgccagttca gcgatctgat 7201 cctcgggcac gccgatgtgg tacagccact ccatgcagat ctcgcggccg gtgcagtcac 7261 gcatgggctt cttgacgtaa tcgccgggct tatcgctgaa caggccgtac acccagacgc 7321 acagctggtt cttgggctga tccttgaact gctgctgacg gttcagcgtc cagctgagca 7381 gccagctgga gtccttgacg gtaacgatgc cgccggtgac agtgtggccg ctgaaggggt 7441 cgcgcttgca gatcttgcgg atatactggg ggatcttgtc gtccagcgtg gtgatggtag 7501 cgctctccca gttgctcagc tccggctcgg agcagaactt ctccgggtga ccgaaagagg 7561 gatcctgtgc ggcgatcttc ttccacagat cccagccgtt gccgggctgg atggtggggt 7621 cgaaaccggt ggccttattc tgtgcgccca cggtgcagct ttccacgcag ccgccgttgg 7681 tgatgaacag cagatcgttc tcggtcaggt cgatattgga agtctcgccc gcgtgctcca 7741 cggtgacaga gcttgccagc ttgcggccct tctggatatc gaacttgaca tcggtgacct 7801 tggtgttgta gtggaactgc acgccaaagc tttccagata gcgcaccatg ggcaggatga 7861 tggactcgta ctggttatag cgggtaaagc gcagggcggt aaagtccggc agaccgccga 7921 tgtggtggat atagcgcttg aggtacagct tcatttccaa agcgctgtgc cagttctcga 7981 aggcgaacat ggtgcgccag tacatccaga agttggtgtt gagcacctcg tcatcgaaga 8041 aatcggtgat ctttttatcc tgcagctgct cgtccggggt gaagaacagc ttcatgatct 8101 ccatggcacc cttatcggac aggccgaact tgccatcggt gtgggcatcc tcgccgcggt 8161 tgacggtggc acggcacaag gagaagttgg ggtcctcctt gttcagccag taatactcgt 8221 ccagcacgct ggcaccctcg gtctccagag aagggatgga gtgcagcaga tcccacatga 8281 cctcgaagtg gttgtccatc tcgcggccgc cgcgcatcac atagccgata tcgtacttgt 8341 agccatcgca ggcaccgccc gccagtgcgt tcttttcaaa cacatggacg tgctcgccct 8401 tcatctggcc atcgcgcacc agatagcagg cagcggtcag ggctgccaga ccggagccga 8461 tgatataagc ggatttatga tccacaccct ccggcttttt gggggttgca aaagcttcgt 8521 agttgccact ggaatagtac ataaaaaagc ctccctgctt cagcgtttta ttttcacagc 8581 cttcatcgtg ctgttctcta tggcaacagt ataccccgca aagtgaactt gaacaacaaa 8641 caaactttgc ccggtgtata gattttttac atccgccctt atttgctgga aatgcgtaca 8701 aattgtgaca taaaagcgat atgcaaaatc tttcagctta gtcgttgcct tgctcttgcc 8761 attttcagcg ggctcgccct ctcagtcatc gctgcgcgat gccagctccc ccaaagtggg 8821 agcccttggc agtccacgca aagttcatct ctttgccaag gcctctccct ttgggagagg 8881 tggatttgcg aagcaaagac ggagagggcg aggatgctcc ccatgtacaa caaaaagaga 8941 gccgccgcac aaaggtctgt gcagcggctc tctatcggtt ttagttcatc tcttccagag 9001 cctttttcag gttctttgcg atctggtccg ggcagctggt gctgcggaag ccgcacagcg 9061 tgccatccag acgggcaatg gcgtcctctg ccttcatgcc ggtgagcagc tggcagatgc 9121 ctttcaggtt gccgttgcag ccgccgatga cctcgatgga tgcaatggtg tggtcatcgt 9181 tcagcacaaa gttggtctgc ttagagcagg tgcccttgtt cgggaaggaa aattccttgc 9241 tcatggtctt tacgtcctct ctcttttacg tttttcggcg atgacgcgca gctgcgctgc 9301 ggcttcgtcc ggtgcggtac aggtaccgat ggggtggggg tgcttgtggt tgcggccatg 9361 gaagtccgtg cccgcagtgg ccacaaggcc gtactgcttg cacagggcaa ggcactcggc 9421 gctgtcctcc gggctgttgc tggggtggta cacctctatg ccgtccactg cgccctctgc 9481 caccagctcg cgcagcaggg gcatactttt gtacaccgtg gggtgggcaa acaccaccgc 9541 gccgccgctg gctttagcgg tagccagcac ctgccgcacc ggcagatact ccggcgagtg 9601 cagtacgatg ccccgggggt tccacccgaa cagcttgtgg taggtctcgc cgtagatgct 9661 gccatcggtc aggcccagca gttccagcgc ctgcatcagc ccgcttttga acagcacccc 9721 gctggccttt gtggtctccc atgcaaggtc ggtggtaaac tgcgggtaca gctgctccag 9781 ctcctttgcg ctctgcaaag cgcaggcgtt gcggcgctcc ttcataatgg cgcagtgctc 9841 ccgcagcgcc gggcagtcca cgtccgggta gtagcacagc aggtgcaccc ggtgctggcg 9901 ctcaaagtcg tagccggtca gctccacggc ggggatcagc tctaccccgt cctgcccggt 9961 gtgggcatag gcgtactggg cgctgagcag ggtgtcgtgg tccgaaaggg cgatggcgtg 10021 cagcccggtg cgggcggcga tggacgccag ccgctcgatg ggcacagcac cgtcggagca 10081 ggtggaatgg atatgcaggt cacaggacat agcgggttac ttccttagtg cttatagaaa 10141 ttgatcaggc agccgtcggc caggatctgg cgctcgtcgg tggtgagcgg agccatgtac 10201 agctcaaact ccttgacggt atcgcccaga acataggcct tgatgttctg caggtcgccc 10261 ttgagtgctt cccgcacatt ggggatgagc acatagtccc ccagaccaaa gggggtggcg 10321 cctgccagct gcaggggcag catgccccag ttgatgaggt tggagcggta acgcttggtg 10381 gcgtactcgg ttacgatatt ggcaccggca cccagcacac gctggcagct ggcggcctgc 10441 tcacgggcag agccgtcgcc gggcttgacc gcaaagatgg tagaggcgat ctggatatcg 10501 ttccagctca gctgttcgca gccgggcacg gcgttcacct ttgccagcag ggcggcgtcc 10561 cctgcaccgg cgcggcgggc agcttcctcg gcctgcacgg ccttggcgcg actcacatac 10621 tccgggtcct tgcggctgag ggtgaactca gccagaccca gcggattgga acggtaagag 10681 gacgtctcgc cggaggggat cagctcgtcg gtggtggtga cggggtcggt gatataagaa 10741 accaccttca gcagcaggtt gtcgcccagt ggtgcgattt ccggccagtc cttgatgttg 10801 gggccaaact tgagcagggc atcgtaatcg cctttgccga agccctgata cacgcgggtg 10861 tcgtagctgg aagcatcgta ctggtactcc ggcacggtgg gatcataatc aatgtcggtg 10921 gcgggggtca ggatgccgcc gtttgcggtg gtggctgcaa tgctgcgggc atccatcagt 10981 gccacaccgg ccagctggcc gctgccgggc ttggagccct cgcggctggg gaagttgcgg 11041 gtggtgtgac ggatggacag tgcaccgttg gcgggcacat cgcctgcgcc gaagcagggg 11101 ccgcagaagg cggtgcggat ggtagcgccg ctggccatca gctcgccgat gacgccggtg 11161 cgcaccagtt ccatcatgat gggctgactg ccggggtaaa cgctcaaggc gtagtcgccg 11221 cagccgccgg tatgaccctt gaggatggaa gccgcctcgt agatgctgtc gtacagaccg 11281 cctgcgcagc ctgcaatgac gccctgatcc acacgcagct tgccgttttc gatcttgctg 11341 cacagatcca gctgcacatc cttgcggccg atcagcttct gcacatcctg ctcgcaggcg 11401 tggagaatgt cctccagatt tgcgttcagt tcctcgatgg taaaggcatt ggaggggtgc 11461 atgggcaggg cgatcatggg acggatggca gaaagatcca cctccaccac accatcgtag 11521 taggcaaggt ctgccggtgc aagtttttta tagtctgctg cacggccatg cactgccaga 11581 aaacgctggg tgacttcgtc ggtctcccag atggaggaca gacaggtggt ctcggtggtc 11641 atggcatcaa tggcgttgcg ggtatcctgc cgcagggaag caatgccggg gcccacgaac 11701 tccatgacct tgttcttgac gtagccgctc ttgaacagct tgcccacaag ggcaatagct 11761 acatcgtggg ggccgcagcc cgccggcaga ctgccggtca ggtagatagc caccacaccc 11821 gggcgggcaa catcataggt gcggcccagc agctgctttg ccagctcgcc gccgccctcg 11881 ccgatggcca tggtgcccag tgcgccgtag cgggtgtggg agtccgagcc aaggatcatt 11941 ttgccgcagc ccgcaaagcg ctcgcgcata tactggtgga tgactgccat gtgcgggggc 12001 acaaagatgc cgccgtactt tttggcggcg gacaggccaa agcggtggtc gtcctcgttg 12061 atggtgccgc ccacagcgca caggctgttg tggcagttgg taagcacata aggaatgggg 12121 aacttttcca gcccggaagc acgggcggtc tggatgatgc ccacaaaggt gatgtcatgg 12181 cttgccatgg catcaaactt gatcttcagg ttctcggcat cgccgctggt gttgtgtgcc 12241 tgcataatat tgtaggccat ggtaccggtc ttagccgcgg caacggcagc ggcatcaaag 12301 ccctttgctg ccagcgctgc gggtgcattg ccatctgcgg gcacccactc tccgcgcgca 12361 tagtacgcac cgccagtgct gcatttgatc atatccaaca tctcgattcg cctctctttt 12421 tgtattttcc cgcccgccgc aattgcgggc attgccccgg cagtgcggct attcatcccg 12481 aaaacagccg tccccttagc cttcacccct tgggggaagg tggcgcacag caccggatga 12541 ggggtatttc ttggcaacag caccctcatc agtcgcctgc ggcgacagct tttcaaagac 12601 ttataacccc tgccctgtta cggcaaaagc cgtatttaac ttttattata gcatgaaagg 12661 gcgaaaagaa aaagcatttt ttatgaaccc ttactgcacc tttgcggcgg cttcctgctg 12721 cttttccttt tgcagtttac ggaacaccac aaaataggcc gggatcagga agaagcaggc 12781 aaagagccat gccaccgggc ttgcgatgca ggcggcaaag tagccccaca gcggcacgaa 12841 ccagaagccc accatggcgc gggcgatcat ctcggccaca ccggcaaaca tggcaaggcc 12901 ggagtgaccc agaccctgaa tggtgtagcg gtagatgata agcactgcca gcgggatgta 12961 gaacacgctg ttccagaaga tgaactcctg cgcattggcc ataatggcgg tctcgcctgc 13021 gtccaggaac aggccgatca ggggcttgtc cagcacgcgc aggatgagga aagaggccac 13081 gctgtacacg cagccgatgc ccagtgcggt gttcacgccg cggttcacgc ggcccagatc 13141 cttcgcgccc atattctggc tggtgtaggt ggtcatggcg gtgccgatgc tctccagcgg 13201 cacgctgagg aactgcgcag ccttgccgcc ggcggtctgc gcggctacga tatcgctgcc 13261 cagaccgttc accgcgccct gcagcaccac gctgccgatg gcagtaatac tgcactgcag 13321 acccatgggg aggcccatgg cgcaaagctt tgcgca //