LOCUS       c00123_gnlPro..        14629 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|KIBFGNFI_123.
ACCESSION   c00123_gnlPro..
VERSION     c00123_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 21:27:00
            Original ID  :: gnl|Prokka|KIBFGNFI_123
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 1865
            Orig. end    :: 16494
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14629
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[11865:16494]"
                     /cutoff="10000"
                     /detection_rule="(not (POR or POR_N or PFOR_II) and
                     minimum(4, [Acyl-CoA_dh_1, Acyl-CoA_dh_2, ECH_2, ETF,
                     ETF_alpha, HCDH_N, Thiolase_N, ketoacyl-synt]) and HCDH and
                     minimum(1, [EC1_2-faecali, ECH1_Enoyl_CoA_DH1,
                     ECH1_Enoyl_CoA_DH2, ECH1_Enoyl_CoA_DH3, ECH1_Enoyl_CoA_DH4,
                     Thiolase_C]))"
                     /neighbourhood="10000"
                     /product="acetate2butyrate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..14629
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(not (POR or POR_N or PFOR_II) and
                     minimum(4, [Acyl-CoA_dh_1, Acyl-CoA_dh_2, ECH_2, ETF,
                     ETF_alpha, HCDH_N, Thiolase_N, ketoacyl-synt]) and HCDH and
                     minimum(1, [EC1_2-faecali, ECH1_Enoyl_CoA_DH1,
                     ECH1_Enoyl_CoA_DH2, ECH1_Enoyl_CoA_DH3, ECH1_Enoyl_CoA_DH4,
                     Thiolase_C]))"
                     /neighbourhood="10000"
                     /product="acetate2butyrate"
                     /protocluster_number="1"
     cand_cluster    1..14629
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(not (POR or POR_N or PFOR_II) and
                     minimum(4, [Acyl-CoA_dh_1, Acyl-CoA_dh_2, ECH_2, ETF,
                     ETF_alpha, HCDH_N, Thiolase_N, ketoacyl-synt]) and HCDH and
                     minimum(1, [EC1_2-faecali, ECH1_Enoyl_CoA_DH1,
                     ECH1_Enoyl_CoA_DH2, ECH1_Enoyl_CoA_DH3, ECH1_Enoyl_CoA_DH4,
                     Thiolase_C]))"
                     /kind="single"
                     /product="acetate2butyrate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14629
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="acetate2butyrate"
                     /region_number="1"
                     /rules="(not (POR or POR_N or PFOR_II) and minimum(4,
                     [Acyl-CoA_dh_1, Acyl-CoA_dh_2, ECH_2, ETF, ETF_alpha,
                     HCDH_N, Thiolase_N, ketoacyl-synt]) and HCDH and minimum(1,
                     [EC1_2-faecali, ECH1_Enoyl_CoA_DH1, ECH1_Enoyl_CoA_DH2,
                     ECH1_Enoyl_CoA_DH3, ECH1_Enoyl_CoA_DH4, Thiolase_C]))"
                     /tool="gutsmash"
     CDS             complement(3705..4787)
                     /locus_tag="ctg123_3"
                     /transl_table=11
                     /translation="MQKLSQTEELARSLAAKARRHTLTPEQISRAMEETDFDVAQLDEL
                     YAALEQRGVHLAEEEPAELPVLDDAQIGRLENELSSEGVALDDPVKTYLKEIGRVPLLT
                     AGQEMALAKAARAGNADARRALSEANLRLVVSVAKRYAGRGLPFLDLIQEGNLGLMKAA
                     EKFEPERGFKFSTYATWWIRQSITRAIADQGRTIRIPVHLVESINRVKKTAGDLLHKNG
                     REPTVEEIAAALDMEPDKVRELLQLSQEPISLETPVGEEEDAHLEDFIQDEDAGVPVDE
                     AGRQLLRRELLHVLKSLTPREERVITLRFGLEDGRARTLEELGKEFNVTRERVRQIEAK
                     ALRKLRHPSRAKLLRDYLDE"
     CDS             complement(4836..6611)
                     /locus_tag="ctg123_4"
                     /transl_table=11
                     /translation="MIPHEYIEELTRRTDIVELVGSYVQLKRKGRLYGGLCPFHSEKTP
                     SFYVYPDTQSFYCFGCQAAGDAISFVKKINNISSGEAIKMLASRAGMPEPQEDDKTGRL
                     RSRVLSMNKEAARFFHACLNSTVEEARQARAYWRRRGLDDKTIVRFGLGYAPNDGQALY
                     QYLRDKGYNQQELDASGLFKRSQSGRIYCLFWKRVMTPIFDLRGNIIAFGGRVMDDSKP
                     KYVNSPETLVYHKSETVFAMQIAKRSASRRFVLCEGYMDVISMQQAGIDTAVCACGTAL
                     TPGQVRIISEYADEVILSYDSDEAGQKATLRSLELFRNSPVKVGVLQIPGAKDPDEYIK
                     KYGPERFQALLDGVGNALDFRLKRLRDQYDLSQDAQRLQYIKDAVEMLAERSNPTEQEV
                     YAGRLAEETNISKTAILAQLGTAAKRAGGKYRREKNRERLHSGEMDQIKVPYSAGGSQA
                     LGIASAQQRLLAAILREPRYLELAKQQLTAEQFIQPQQKELYEAMLNCSREGVELSLTA
                     LRAFASEEALNELSRLAAQYSDVNCTPEDIHLYLDRIARGMPVASKAAAMSGDEITQYL
                     QSMREKKQGTLPEQD"
     CDS             complement(6637..7635)
                     /locus_tag="ctg123_5"
                     /transl_table=11
                     /translation="MDVRRRTEEIEHLTFAPWATFSDASRGRVVPEPQDPLRPVFQRDR
                     DRVLHCKAFRRLKQKTQVFLSPEGDLYRTRLTHTLEVSQIARTIARGLRLNEDLTEAIS
                     LAHDLGHTPFGHAGEKALNDLCPEGFHHYMQSLRVVDRLEKDGEGLNLTWEVRNGIVTH
                     TKGTWAATPEGRIVRLADQIAFVNHDIEDAVRAGVLDAATLPKDCTAVLGQTKSARITT
                     MINSILTHSEGDVRMGTEEYEAFLALRDFMYATVYVDKNAKREEQKVDKLIAELYEYYL
                     THVDRMSNFYVQLAYQEGRERAVTDYISGMSDEFAIRTFEELFVPQKWHVL"
     CDS             complement(7780..8400)
                     /locus_tag="ctg123_6"
                     /transl_table=11
                     /translation="VEDYRTVRGTATGEYEEKKSRFIAQLSFADSEEAAVAFLEQVRAA
                     NRTARHNVYAYRLRAGNRERYSDDGEPAKTAGTPALEVLQHSGLTDLIVVVTRYFGGVL
                     LGTGGLVRAYTIATARALENAEVVTVRSVVELQVTVDYALYERASLLIDAAGAKQAPPE
                     FTDRVTLRWQMPEHTEAPLLEQLRELTRGSAQVTVSDPFYAPF"
     CDS             complement(8514..9452)
                     /locus_tag="ctg123_7"
                     /transl_table=11
                     /translation="MKRAMSTVKNIAAAAMTLAVVFGFAGFKPVTANAAQAAVPATASV
                     EEENSYFEEDAYQRSFLTLVNNERAQAGLAPVALGDSSHNAAAMERAEELAVSYSYVRP
                     NGQRDFTVLAENGISDVSIGENYMAGCSTPDAAMDQWMATDFTRERILNADATTVSVGH
                     YEGGVYNNYWVLIFSYPENSHTEDYRQEVLDLVNAQRAKYGLTALEMGDDDLTAAAQTR
                     AEEIAVVNSHVRPDGSKCFTVLKDYGVTDTPTGENAAWGSVSPEEVVNAWMNSEGHRAN
                     ILNPEARKMSVGYYYNSNSTWGHQWIQIFTK"
     CDS             complement(10001..11095)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: ETF_alpha"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: ETF"
                     /gene_functions="electron_transport (smcogs)
                     SMCOG1009:Electron-transferring flavoprotein (Score: 111.3;
                     E-value: 6e-35)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg123_8"
                     /sec_met_domain="ETF (E-value: 1.3e-47, bitscore: 151.7,
                     seeds: 129, tool: rule-based-clusters)"
                     /sec_met_domain="ETF_alpha (E-value: 1.2e-35, bitscore:
                     111.3, seeds: 511, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MADFNEYKGVWVFCEQRQGALMSTDFELVSEARKLADELGCEVTG
                     LLLGDNVEGIAKELGGYGADKVLVCDSPLLKDYTTDAYAKVVCDMVNEYKPEVLLIGAT
                     NIGRDLGPRCAARLHTGLTADATHLDIDTAKYIDFLKESSTIDLSKQKFDMEDRNLKMT
                     RPAFGGHLMATIICPRFRPQMSTVRPGVMKKAPFDQAKADACQIVKPAFSLTAEDIKTE
                     VLSVEKAAEKLVDLIGADVIVSVGRGISKDVHKGIELAEQLAAALGGGVVGASRAVTDA
                     GWMTADHQVGQTGKTVHPKIYVALGISGAIQHTAGMQDSECIIAVNKNEGAPIFGVADY
                     GIVGDLFKVVPELIKQIEAAKAAL"
     CDS             complement(11117..11911)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: ETF"
                     /gene_functions="electron_transport (smcogs)
                     SMCOG1008:Electron-transferring flavoprotein (Score: 157;
                     E-value: 1.6e-48)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg123_9"
                     /sec_met_domain="ETF (E-value: 3e-49, bitscore: 157.0,
                     seeds: 129, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKAIVCVKQVPDTSGKVSVKPDGTLDRASMATITNPDDLNALEAA
                     LKLKDATGCEVVVVTMGPPPAEGMLRELLARGADKAVLVSGREFGGSDTFATSQILAAA
                     VNKIGVGPEDVVFCGRQAIDGDTAQVGPQIAEKLHLPQVTYVADIQKDGNTLTVKRMLE
                     DGYMMVKVQTPCLLTCIKELNDPRYMSVNGIFTCYDKPMEVFDYNALKDDPLIEVDTIG
                     LKGSPTNVFKSFTPPQKGAGTMLQGDDVAAQLAGILAKKHLI"
     CDS             complement(11929..13098)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg123_10"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 3.6e-50, bitscore:
                     159.8, seeds: 49, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 4.5e-30, bitscore:
                     93.5, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 1.3e-40, bitscore:
                     128.4, seeds: 796, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDFTLSKQQQMVQKMYREFAENEVKPLAKKVDAEEYFPKETVEKM
                     GKLGMMGIYFPTEVGGAGGDVLSYVMAVEELSKVCGTTGVIVSAHTSLCAAPIYENGTP
                     EQKAKYLPKLCSGEWLGAFGLTEPGAGTDAQGQQTIAKEDGDYWVLNGSKIFITNAGFA
                     DVFIVIAVTDNVLDKRGRPTKLCSAFIVERTDPGFSVGKAEDKMGIRGSSTCELIFEDC
                     RIPKDRMLGVRGKGFQLAMATLDGGRIGIASQALGIAEGALEETIAYVKERKQFGRAIA
                     AFQNTQFELAEMKARVEAAKYLVYAAALKKQQAMDGAKVRYSVEAAQAKLIAARTASDV
                     TRRCLQLFGGYGYTRDYPIERMMRDAKITEIYEGTSEVQMMVISGALLK"
     CDS             complement(13205..14077)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: HCDH_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: HCDH"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) F420_oxidored"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg123_11"
                     /sec_met_domain="HCDH (E-value: 9.2e-35, bitscore: 109.0,
                     seeds: 68, tool: rule-based-clusters)"
                     /sec_met_domain="HCDH_N (E-value: 2.5e-61, bitscore: 196.4,
                     seeds: 60, tool: rule-based-clusters)"
                     /sec_met_domain="F420_oxidored (E-value: 6e-08, bitscore:
                     23.0, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIGVIGAGTMGQGIAKAFAQVEGNTVALCDIKQEWAENGLAKIK
                     KGYEKLVAKGKMTQEKADAIVAAITPGLKEDLCADCDLVVEAAFEDMKVKQTTFGELDK
                     ICKPECVFASNTSSLSITEIGKGLSRPLIGMHFFNPADRMKLIEVIAGCNTPAETVEKI
                     KEISVAIGKSPVQVNEAAGFVVNRILIPMINEAAFIKMEGVSDIAGIDTAMKLGANHPM
                     GPLELGDFIGLDICLAIMDVLYNETGDSKYRACPLIRKMVRGGNLGCKTGKGFYVYNAD
                     RTKTPVDQL"
     CDS             complement(14120..14629)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     acetate2butyrate: EC1_2-faecali"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg123_12"
                     /sec_met_domain="EC1_2-faecali (E-value: 3.7e-69, bitscore:
                     222.5, seeds: 67, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="FPIPVIAAVNGFALGGGNELAMSCDIRICSDNAVFGQPEVGLGIT
                     PGFGGTQRLARLVGMGMAKQLVYSALNIKADEALRIGLVNAVYPQAELMENVLKLAGKI
                     AKNAPIAVRNCKKAINGGISLPIEKAVEVEEKLFGSCFETHDQKEGMACFLSREKPKPK
                     AVFTNN"
ORIGIN
        1 gatcttggag aagtcgatga tgtggccctt ctcgcccatg atcttgggca gcttggtggg
       61 atatgcggga gcattctcgc cgtgccacat ctcgcgggcg gtatcaaaag tatcgccgat
      121 gtcgttctca cgggcagagt caaagacagg ggtcatgacc ttgatgccgc aggccttggc
      181 agcgtagccg aggttgactt ccagcacctg accgatattc atacgggaag gcacgcccag
      241 cgggttcagc acgatgtcca gcggagtgcc gtcgggcagg tagggcatat cctcctgcgg
      301 caggatgcgg gaaacgacac ccttgttacc gtgacggcct gccatcttat cgccgacgct
      361 gatcttacgc ttctgggcga tatagcaacg gacgacctcg cgcacaccgg gctgcagctc
      421 gtcgctgttc tccggggtaa agaccttgac atccacaatg atgccgtatg cgccgtgagg
      481 cacacgcaga gaggtgtcgc gcacctcgcg ggccttctcg ccgaagatgg cgcgcagcag
      541 gcgctcctca gcggtcagct cagtctcgcc cttcggggtg accttaccga ccagaatatc
      601 gccgctcttg acctcggcac cgatgcggat gatgccgcgc tcgtccagat ctttcagggc
      661 gtcctcagaa acgttgggga tgtcgcgggt gatctcttcg ggtcccagct tggtatcgcg
      721 gctctcggtc tcgtactcct cgatgtggat ggaggtgtac acgtcctcac gcacgatctt
      781 ctcgttcagc aggacggcgt cctcgtagtt gtagccctcc caggtcatga agccgatcag
      841 ggcgttctta cccagagaga tctcgccgtt gcgcattgcg gggccatcgg ccagcacctg
      901 accggcggtg acggtctcgc ccacttctac gatggggcgc tggttgatgc aggtgcctgc
      961 gttggagcgg gcaaacttga tcagagaata atcctccaga gcgccctgct cgttgcgcac
     1021 cacaacatgg tcggcatcga ccttttccac aacgccgttg ctcttggcca gcacagcggt
     1081 gccggagtcg gtagcagcct tgtactccat accggtagca acaatgggct gctgggtgac
     1141 catcagaggc actgcctgac gctgcatgtt agagcccatc agtgcacggt tacagtcatc
     1201 gttctccagg aaggggatgc aagcggtagc aacagagacc atcattcgcg gagaaacgtc
     1261 catgtaatcg actttctctg cgtcgatttc caggatctcg tcgcggcggc gggcagacac
     1321 acggggacgg atgaagtgct tgccttcatc cagcggctcg ttggcctgtg ccacaacgta
     1381 ctcgtcctcc acatcggcgg tcatatactc cacctcatcg gtgacgacct gctcgatgag
     1441 attgttgttc tcgtcgtaga tcttcttgac cttgcggtag ggagcctcca cgaagccgta
     1501 ctcgttgatc ttggcgtagg atgccagata ggagatcaga ccgatgttgg ggccttcagg
     1561 ggtctcaatg gggcacatac ggccatagtg gctgtaatga acgtcgcgga cttcgaagcc
     1621 tgcgcggtca cggctcagac cgccggggcc cagagcagac agacggcgct tgtgggtcag
     1681 ctcagccaga gggttattct gatccatgaa ctgagacagc ggagaggagc cgaagaactc
     1741 cttgatggct gccaccacag gacggatgtt gatcagtgcc tgcggagtga tgacgctctg
     1801 atcctgactc tgcagggtca tacgctcacg gatgacgcgc tccatacggg agaaaccgat
     1861 gcggaactgg ttctgcagca gctcgcccac gctgcggata cggcggttgc ccagatggtc
     1921 gatatcatcg gtggtgccga tgccgtagcc cagaccgttc aggtagttga tggaggacag
     1981 gatatcgtcg atggtgacgg tacggccgat gagcaggtcg tgatccttct tcaggctctc
     2041 catgacctcc tcggcgctgg aggcgttatc aaggatcttg cgcagctcct tgaggcagca
     2101 gcgctcgttg atgccgcact ccttgacatc cacacccttg aatgcggggt agtagctgtc
     2161 gatgatggcc tgtgcgtcca cgcagccgtt ggtgatgacc ttgaccttgt ggggctgatc
     2221 cttcatggga tcatcgatct tcagcacgac cagattcacg ccggcagcat cgatcttctc
     2281 agccagcttg cggtcgatct tcttgtcggc ctcgacaagg atctcgccgg tgaagggatc
     2341 caccacgttc tctgcggcca catggtccat gatgcggcgt gccagagaca gcttcttatt
     2401 catcttatag cggccgaagc gggacaggtc gtaccggcgc ggatcgaaga acagcatatc
     2461 gatctggctg gtagcggact ccaccgtggg gggctcgccg gggcgcagct tgcggtagac
     2521 ttccagcagg ccctcctcgc ggttcttggt ggtatccttt tccagcgtgg ccagaatgcg
     2581 ctcgtcctcg ccgaagtagt tcaggatatc ctcgttagag gacaggccca gtgcacggca
     2641 cagcacggtg acgggcagct tacggttctt atcgatacgg acatagaaca cgttggcggc
     2701 atcggtctcg tactccagcc atgcaccgcg gttggggttc atggtggcgc tgtacaggtc
     2761 gttgccgacc ttatccttcg catggccgta gaacacaccg ggagaacgga ccagctggct
     2821 gacgattgca cgctcggcac cgttgatgac aaaggtgcct gcgtcggtca tcagggggaa
     2881 gtcacccatg aagatctcct gatccttcac ctcgccggtc tccttgttca gcagacgggc
     2941 agtgacgcgc aggggggctg caaaggtaac gtcgcgctcc ttgcactcct tgatgctgta
     3001 cttcggctcc ttatccagcc ggaagtccac aaagctcagt gccagattgc cggtgtagtc
     3061 ctcaatggtg ccgatatcgt ggaagacctc cttcaggcct tcatccagga accactgata
     3121 cgagttcttc tgcacctcga tcaggttcgg catactgatg acttcgtcga tgtgggagaa
     3181 gctcatgcgc tcggttttgc cgagctttac gggcttgact ttcatcataa aatcaaccac
     3241 tccttacttt tatattctac gggatgtcgt atacgcgggt caaatttgag cagacacaca
     3301 taattcgacc cgcgtcctgt ggaaccttcc ggcattttgc acaaactttt cggggtgacc
     3361 cctcaagtgg cagccatcac agctcccttt ttgacgcact agtccattat gtgatactaa
     3421 tgcagtatac accccaaaac ccctgttgtc aagccatttt tcagtttttt gccgaaataa
     3481 atttaatttt cgctttgttt tcgcacgccc ggcagcgtgt agtcgtttgt ctgccaagta
     3541 cttgattttt ttattttgca cgttcctgtt cataacaccc ttgtgcaatt tgtctatctt
     3601 tactcttgtg cccggaagtg tgacttttgc acttccctgc cgcaaaaaag agaccgccgc
     3661 acaaaatgct gtgcagcagt ctcgtcctga aaattttatg cgattcactc gtccagataa
     3721 tcccgcagca gcttcgcgcg gctggggtgg cgcagcttgc gcagcgcctt tgcttcgatc
     3781 tgccgcaccc gttcccgggt cacgttgaac tccttgccca gctcttccag cgtgcgggca
     3841 cggccatcct ccaggccaaa gcgcagggtg atgacccgct cctcccgggg tgtcaggctt
     3901 ttgaggacgt gcagcagctc ccgccgcagc agctgacgcc cggcttcgtc taccgggaca
     3961 ccggcatcct cgtcctgaat aaagtcctcc agatgagcgt cctcttcctc ccccaccggc
     4021 gtttccagac tgatgggctc ctgcgacagt tgcagcagct cccgcacctt gtccggttcc
     4081 atatccagtg cggcggcgat ctcctccacg gtgggttccc gcccgttttt gtgcaacagg
     4141 tcgcctgctg ttttcttgac ccggttgatg ctctccacca gatgcaccgg gatgcggatg
     4201 gtgcgtccct gatccgcaat ggcgcgggtg atggactggc ggatccacca cgttgcgtag
     4261 gtggagaatt tgaacccccg ctccggctca aacttttccg ccgccttcat caggccgagg
     4321 ttgccctctt gaatcaggtc caaaaaaggc agtccccgtc cggcgtagcg cttggcgacc
     4381 gataccacca gccgcaggtt tgcctcgctc aaagcgcggc gggcatctgc attccctgcc
     4441 cgggcggcct ttgccagcgc catctcctgc ccagcggtca acagcggcac ccggccgatc
     4501 tcctttaaat aggtcttgac cgggtcatcc agcgccacac cctccgagga aagctcattt
     4561 tccagcctgc cgatctgggc atcatccagc acaggcagct cggcaggctc ctcctctgcc
     4621 agatggacgc cccgctgctc cagcgcagcg taaagctcgt ccagctgtgc aacatcgaaa
     4681 tccgtttcct ccatggcgcg gctgatctgc tccggggtca gggtgtgacg gcgagccttt
     4741 gcggcaaggc tgcgggcaag ttcttccgtt tgcgacaatt tctgcatgat tcctgctcct
     4801 tttctctcca gctccagccg gagggaaaac agggatcagt cttgttcagg cagcgtcccc
     4861 tgcttttttt cgcgcatcga ctgaagatac tgtgtgatct catcgccgga cattgcagca
     4921 gctttgcttg cgaccggcat cccccgggcg atcctgtcca gatacagatg gatgtcctcc
     4981 ggggtgcagt tcacatcgct gtattgtgcc gcaagtcggc tcagttcatt caatgcttct
     5041 tcgcttgcaa atgcccgcag tgccgtcagg ctgagctcca cgccctcccg gctgcaattg
     5101 agcattgctt cgtataattc cttctgctgc ggctggataa attgctccgc cgtcagctgc
     5161 tgtttggcca gttccagata gcgcggctcc cgcaggatgg ctgccagcag ccgctgctgg
     5221 gcactggcaa tgcccagcgc ctgactgccg cctgcgctgt atggtacctt gatctgatcc
     5281 atctcaccgg agtgcaggcg ctcgcggttt ttctcccggc ggtacttgcc gcccgcccgc
     5341 tttgctgcgg tgcccagctg cgccagaatg gcggttttgg agatgttggt ctcctctgcc
     5401 agccgcccgg cgtacacctc ctgctcggtg gggttggagc gctcggccag catctccaca
     5461 gcatccttta tatattgcag acgctgcgcg tcctgcgaga gatcatactg atcccgcagg
     5521 cgcttgagcc ggaagtccag cgcattgccc accccatcca gaagcgcctg aaagcgctcc
     5581 gggccatatt ttttgatata ctcgtccggg tcctttgcac cggggatctg caaaacgccc
     5641 acctttaccg ggctgttgcg gaacagctcc agcgagcgca gggtcgcctt ctgaccggcc
     5701 tcatccgagt catagctcag aatgacctcg tcggcatatt cgctgatgat gcgcacctgc
     5761 ccgggggtca gggcggtgcc gcaggcgcag acggcggtat caatgcccgc ttgctgcata
     5821 ctgatgacgt ccatgtagcc ctcgcacagc acgaaccgcc gggaggcgct gcgcttggcg
     5881 atctgcatgg caaacaccgt ctcggatttg tggtagacca gcgtttccgg gctattgacg
     5941 tatttgggct tggagtcgtc catcacgcgc ccgccaaagg ctatgatatt gccgcgcaga
     6001 tcaaagatgg gggtcatgac acgcttccag aacaggcagt agatgcgacc ggactggctg
     6061 cgcttgaaca agccgctggc gtccagctcc tgctggttgt agcccttatc ccgcaggtac
     6121 tggtacagtg cctgcccgtc gttgggggca tagcccaacc cgaaccggac gatggtctta
     6181 tcgtccagtc cgcgccgtcg ccagtaggcg cgcgcctgcc gcgcctcctc cacggtagag
     6241 ttcaggcagg cgtggaaaaa gcgggccgcc tccttgttca tggagagcac ccggctgcgc
     6301 aggcgtcccg tcttatcgtc ctcctgcggt tccggcatcc cggcgcggga agccagcatc
     6361 ttgatggctt cgccgctgct gatgttgttg atctttttga caaagctaat ggcatctcct
     6421 gccgcctgac agccgaagca gtaaaagctt tgggtgtcag ggtacacata gaaggacggt
     6481 gttttttcgc tgtgaaaggg gcacagaccg ccgtacagac gtcccttgcg cttgagctgc
     6541 acatagctgc ccaccagttc cacgatgtcg gtgcggcggg taagctcctc gatgtattca
     6601 tgtgggatca tgttgattta aacgacctct ccagttttaa aggacgtgcc atttttgggg
     6661 cacgaacagt tcttcaaagg tgcggatggc aaactcgtcg ctcatcccgc tgatgtagtc
     6721 ggtgacggcg cgttcccgtc cctcctgata ggccagctgc acataaaagt tggacatccg
     6781 gtccacatgg gtcaggtagt actcgtacag ctccgcgata agcttgtcca ccttttgctc
     6841 ctcgcgcttg gcgtttttgt ccacatacac ggtagcgtac atgaaatccc gcagggcgag
     6901 aaacgcctcg tattcctctg tgcccatgcg gacatccccc tcgctgtggg tgaggatgct
     6961 gttaatcatg gtggtgatgc gggcggattt ggtctgcccc agcaccgctg tgcagtcctt
     7021 gggcagggtg gcagcgtcca gcacaccggc tcgcacggcg tcctcaatat catggttgac
     7081 aaaggcaatc tgatctgcca agcgcacgat gcgcccttcc ggggtagctg cccatgtgcc
     7141 cttggtgtgg gtgacgatgc cgttgcgcac ctcccatgtc aggttaagcc cctcgccatc
     7201 cttttccagc cggtccacta cacgcaggct ctgcatataa tggtgaaagc cttccgggca
     7261 aagatcgttc agcgcctttt cgcctgcgtg gccaaaaggg gtgtgtccca gatcatgcgc
     7321 aaggctgatg gcctcggtca gatcctcgtt caggcgcagg ccccgggcga tggtgcgggc
     7381 gatctgcgag acctccagcg tatgggtcag ccgggtgcgg tacaggtcgc cctccggcga
     7441 gaggaacacc tgcgttttct gcttgagacg ccgaaaggcc ttgcagtgca gcacccgatc
     7501 gcggtcccgc tgaaacaccg ggcgcagcgg gtcctgcggc tccggcacga ctctgccgcg
     7561 gcttgcatcg ctgaaggtcg cccaaggcgc aaaggtaagg tgttcgatct cctcggttct
     7621 ccggcgcaca tccatacaga tcctcctttt attttttcgg gcttctcccc ctcccctctg
     7681 cacgcagccg atcccaattg ctgcgctaca gcaattgtag cacatcggca gtgtcgaagg
     7741 gggaagttcg gtgtcggttt gcaaaaaaga ctttgttttt taaaatggtg cgtagaacgg
     7801 atcagacacc gttacctgag cgctgccccg ggtcagttct cgcagctgct ccagcaacgg
     7861 cgcttcggtg tgctccggca tctgccagcg caaggtgacc cggtctgtaa actccggcgg
     7921 tgcctgtttt gccccggcgg cgtcaatgag cagagatgca cgctcgtaga gggcgtagtc
     7981 cacggtgacc tgcagttcca ccacgctgcg caccgtgacc acctcggcat tttccagtgc
     8041 gcgggcggta gcgatggtgt aggcacgcac caagccgccg gtgcccagca gcactccgcc
     8101 aaagtagcgg gtgaccacca cgatcaggtc tgtcaggccg ctgtgctgca gcacctccag
     8161 cgcgggcgta ccggcggtct tggccggctc gccgtcatcg gaatagcgct cgcggttgcc
     8221 cgcccgaagg cggtaggcgt aaacattgtg ccgcgcggtg cggttggctg cccgcacctg
     8281 ttccagaaag gcaacggcgg cttcctcgct gtcggcaaag gaaagctgcg cgataaagcg
     8341 gctctttttc tcttcgtatt cgccggtagc cgtgccccgg acggtgcggt aatcctccac
     8401 gtcagatcct cctgataata attcaaaata agtataacac aaacaggcac aaataaaaag
     8461 actgacgaag ccttgcggcc tcgccagtct ttttataaga agaaagcagt tgatcacttg
     8521 gtaaagatct ggatccactg atgaccccaa gtgctgttgc tgttatagta gtagccaaca
     8581 ctcatcttgc gagcctcagg gttcaggata ttggcgcgat ggccttcgga gttcatccat
     8641 gcgttgacga cctcttcagg agagacgctg ccccatgcgg cattctcgcc ggtgggggta
     8701 tcggtgacgc cgtagtcctt caggacggtg aagcacttgg agccatcagg acggacgtgg
     8761 gagttcacaa cggcgatctc ctcggcgcgg gtctgtgcag cggcggtcag gtcgtcatcg
     8821 cccatttcca gagcagtcag accgtacttt gcgcgctgag cattgaccag atccaaaact
     8881 tcctgacggt aatcttcagt gtgggaattt tcggggtaag agaagatcag cacccagtag
     8941 ttattgtaga cgccgccttc gtagtggcca acactcacag tagtagcatc ggcgttcagg
     9001 atacgctcgc gggtaaaatc ggtagccatc cactgatcca ttgcggcatc gggggtggag
     9061 cagccggcca tgtagttctc gccgatagag acatcgctga tgccgttctc tgccagaaca
     9121 gtaaaatcgc gctgaccgtt gggacgaacg taggagtaag aaaccgccag ctcttcggca
     9181 cgctccattg cagcggcgtt gtggctgctg tcgcccagag caacgggagc cagaccggcc
     9241 tgtgcgcgct cgttattgac cagagtcagg aaactgcgct ggtaggcgtc ttcctcaaag
     9301 taagagtttt cttcttccac agaagcggtg gcaggaacag cagcctgcgc ggcgtttgcg
     9361 gtgacgggct tgaagcctgc aaagccaaaa accacagcca gcgtcattgc agctgctgcg
     9421 atattcttta cggtactcat tgcacgcttc ataagattgc ctccggtctg ttgccttatg
     9481 cagtgtgatg ttggatgttg caactcattt gcaactctgt cgtatcacat ccgcaactct
     9541 tgtgtcacaa gagtatcaca aaaccataca gacgtcaaga ggttcagagg ctgttttgaa
     9601 gaaaaaatac agattttttt aaaaaattcc gttcttttat cgcaactcaa gcgtaacaaa
     9661 gagtccgaaa acgttacagt tgtgttgcac ttcttctcaa aatcagccga gtgcaacagg
     9721 catcgcacac ttttggggac gttctggtgc gctccggttt gcatattata gtatttatat
     9781 acatttattt gcatatcaaa gctttgtgta cgcttttgtg ccgcttcgtt ctattccctt
     9841 ctccgttcct ttcccgtgga aagcaaattg gagctgctgt gcagtggctg gcacaacagc
     9901 tcctttataa aaaacacaaa aaagaggccg ctgcacaaaa atgtgcaacg gcctctcaca
     9961 attcaggcta tgctattgaa caatgctcag gaacaggcga tcacagagca gcctttgctg
    10021 cctcgatctg cttgatcagc tcaggcacga ccttgaacag atcgcccacg atgccgtagt
    10081 cagcaacgcc gaagatggga gcaccctcgt tcttgttgac agcgatgatg cactcagaat
    10141 cctgcatacc ggcggtgtgc tggatggcac cagagatacc cagagccaca tagatcttgg
    10201 ggtgcacggt cttgccagtc tgaccgacct gatggtcagc ggtcatccag cctgcatcgg
    10261 tgacggcacg ggaagcgccc acgacaccgc cgcccagagc ggctgccagc tgctcggcca
    10321 gctcgatgcc cttgtggaca tccttgctga taccacgacc aacggagaca atgacatctg
    10381 caccgatcag gtcgaccagc ttctcagcgg ccttctccac gctcagcact tcggtcttga
    10441 tgtcctcagc ggtcaggctg aaggcgggct tgacgatctg gcaggcatca gccttggcct
    10501 gatcgaaggg agccttcttc ataacgccgg gacgcacggt ggacatctgg ggacggaagc
    10561 gggggcagat gatggtagcc atcagatggc cgccgaatgc gggacgggtc atcttcaggt
    10621 tgcggtcttc catatcgaac ttctgcttgg acaggtcgat ggtggagctc tccttcagga
    10681 agtcgatgta ctttgcagtg tcgatatcca gatgggtagc gtcggcggtc aggccggtgt
    10741 gcagacgggc tgcgcagcgg gggccgaggt cgcggccaat gttggtagcg ccgatcagca
    10801 gcacctcagg cttgtactcg ttgaccatat cgcacacgac cttagcgtat gcgtcggtag
    10861 tgtaatcctt cagcaggggg ctgtcgcaga ccagaacctt gtcggcaccg tagccgccca
    10921 gttccttggc aatgccctcc acgttgtcgc ccagcagcag gccggtgacc tcgcagccca
    10981 gctcgtcggc cagcttacgg gcctcgctaa ccagctcgaa gtcagtggac atcagtgcgc
    11041 cctggcgctg ctcgcaaaag acccatacgc ctttgtattc gttaaaatca gccattgtaa
    11101 tcctatgctc ctttcatcag atcaggtgct tcttggccag gatgccagcc agctgggcag
    11161 caacatcgtc gccctgcagc atggtgcctg cgcccttctg cggaggagtg aaggacttaa
    11221 agacgttcgt cggagaaccc ttcaggccaa tggtgtccac ctcgatcagc ggatcgtcct
    11281 tcagtgcgtt gtagtcgaac acttccatgg gcttatcgta gcaggtaaag atgccgttca
    11341 cgctcatgta gcgggggtcg ttcagctcct tgatgcaggt cagcaggcag ggagtctgca
    11401 ccttgaccat catgtagccg tcctccagca tacgcttcac ggtcagggtg ttgccgtcct
    11461 tctggatgtc ggcaacgtag gtgacctgcg gcagatgcag cttttcagcg atctgggggc
    11521 cgacctgtgc ggtatcgcca tcgattgcct gacggccgca gaacacaacg tcctcggggc
    11581 caacgccgat cttgttgaca gcagcagcca ggatctggct ggttgcaaag gtatcggaac
    11641 cgccgaactc acggccggag accagaacag ccttatcagc gccgcgggcc agcagctcac
    11701 gcagcatgcc ctctgccggc gggggaccca tggtgacaac aacgacctcg cagccggtgg
    11761 cgtccttcag tttcagggcg gcctccagag cgttcaggtc atcggggttg gtgatggttg
    11821 ccatggatgc acgatccaga gtgccatcgg gcttgacgga caccttgccg gaggtatcag
    11881 gaacctgctt tacacaaaca attgctttca ttgtaactct tgcctccctt acttcagcag
    11941 cgcgccggaa atgaccatca tctgcacttc gctggtgccc tcgtagatct cggtgatctt
    12001 ggcatcacgc atcatgcgct cgatggggta gtcacgggtg tagccgtaac caccgaacag
    12061 ctgcaggcag cggcgggtca catcgcttgc ggtgcgggct gcgatcagct tagcctgtgc
    12121 agcctcgacg ctgtaacgaa cctttgcgcc atccatagcc tgctgcttct tcagagcggc
    12181 agcataaacc agatacttag cagcctcaac acgagccttc atctcagcca gctcgaactg
    12241 ggtgttctgg aaagcagcga tggcacggcc gaactgcttg cgctccttga cgtaagcaat
    12301 ggtctcctcc agagcgccct cggcaatgcc cagagcctga gaagcgatgc cgatacggcc
    12361 gccgtccagc gtagccattg ccagctggaa gcccttgccg cgcacgccca gcatacgatc
    12421 cttcgggatg cggcaatcct caaagatcag ctcgcaggta gaagaaccgc ggatgcccat
    12481 cttgtcctct gccttaccaa cagagaagcc cgggtcggtg cgctccacga tgaaggcgga
    12541 gcagagcttg gtgggacggc cgcgcttatc cagcacgtta tcggtaacgg cgatgacgat
    12601 gaacacatca gcaaagccgg cgttggtgat gaagatcttg gagccgttca gcacccagta
    12661 atcgccatct tccttggcaa tggtctgctg accctgcgca tcggtaccag cgcccggctc
    12721 ggtcaggccg aaagcaccca gccactcgcc gctgcagagc ttcggcaggt acttagcctt
    12781 ctgctcgggg gtgccgttct cgtaaatggg agcagcgcac aggctggtgt gagcagagac
    12841 gatgacaccg gtggtgccgc agaccttgct cagctcctcc acggccatga cgtaggacag
    12901 cacatcgccg cctgcaccgc cgacctcagt cgggaaatag atgcccatca tgcccagctt
    12961 gcccatcttt tcgacggtct ccttggggaa gtattcctct gcgtcaacct tctttgccag
    13021 aggcttgact tcgttctcag caaactcgcg gtacattttc tgcaccatct gctgctgctt
    13081 ggacagagta aaatccatcg ctatatcctc ctaacaggtc ttttttcatt taccggaata
    13141 gcccggtgca aacaaattcc tcccgaccgc tttccccgca gccgggagaa atgtttatca
    13201 gaatttacag ctggtcaaca ggggtcttgg tgcggtctgc gttgtaaacg tagaagccct
    13261 taccggtctt gcagcccaga ttgccgccac gcaccatctt gcggatcagc gggcaggcac
    13321 ggtacttgct gtcgccggtc tcgttgtaca gcacgtccat gatggccaag cagatgtcca
    13381 gaccgatgaa gtcgcccagt tccaggggtc ccatggggtg gttagcaccc agcttcatag
    13441 cggtgtcgat gccagcgata tcggaaacgc cctccatctt aatgaaggca gcctcgttga
    13501 tcatggggat caggatgcgg ttgaccacaa agccggcagc ctcgttgacc tgaacggggc
    13561 tcttgccgat ggcaacggag atctccttga tcttctcaac ggtctcggcg ggagtgttgc
    13621 agccggcgat gacctcgatc agcttcatac ggtctgcggg gttgaagaag tgcataccga
    13681 tcaggggacg ggacagaccc ttgccgatct cggtaatgga cagagaagaa gtgttggaag
    13741 cgaaaacgca ctcgggcttg cagatcttgt ccagctcgcc gaaggtggtc tgcttgacct
    13801 tcatatcctc gaaagcagcc tcaacgacca gatcgcagtc tgcgcacaga tcttccttca
    13861 ggcccggggt gatggcggcg acgattgcgt cggccttctc ctgggtcatc tttcccttag
    13921 cgaccagctt ctcgtagccc ttcttgatct ttgccagacc attctcagcc cactcctgct
    13981 tgatgtcgca cagagcaacg gtgttgccct caacctgtgc aaatgccttt gcgatgccct
    14041 ggcccatggt gccagcgccg ataacaccga tcttcatagg aaacctctcc tttaatatca
    14101 aaaattatgt agtaatggat tagttgttgg tgaacactgc cttgggcttc ggcttctcac
    14161 ggctcaggaa gcaggccatg ccttccttct ggtcgtgggt ctcgaagcag ctgccgaaca
    14221 gcttttcctc gacctcaaca gccttctcga tgggcaggct gatgccgccg ttgattgcct
    14281 tcttgcagtt gcgtacagcg atgggtgcat tctttgcgat cttgccggcc agcttcagca
    14341 cgttctccat cagttcagcc tgaggataca cagcgttcac cagaccaatg cgcagagcct
    14401 cgtccgcctt gatgttcagt gcagagtaga ccagctgctt tgccataccc atgccgacca
    14461 gacgtgccag acgctgggtg ccgccgaagc ccggggtgat gcccagaccc acttccggct
    14521 ggccgaacac agcgttgtca gagcagatgc ggatgtcgca gctcatagcc agctcgttgc
    14581 cgccgcccag tgcaaagccg ttgacggctg caatgacggg gatggggaa
//
