LOCUS       c00036_gnlPro..        14847 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|HEKJFJML_36.
ACCESSION   c00036_gnlPro..
VERSION     c00036_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 20:42:31
            Original ID  :: gnl|Prokka|HEKJFJML_36
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14847
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14847
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2732:9645]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      2733..9645
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..14847
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14847
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             complement(3..113)
                     /locus_tag="ctg36_1"
                     /transl_table=11
                     /translation="MSRTDFNTLLEAGAHFGHLKRKWNPKMAPYIFMEKNG"
     CDS             complement(327..713)
                     /locus_tag="ctg36_2"
                     /transl_table=11
                     /translation="MEVVNTVGRRKAAVARVYVKPGKGQITINRKALEVYFPLEILQYQ
                     VKQPLLATNTAENYDIVINLDGGGITGQASAARLGIARALCEIDAEMRPVLKKAGFLTR
                     DSREVERKKPGQPGARRKFQFSKR"
     CDS             complement(719..1174)
                     /locus_tag="ctg36_3"
                     /transl_table=11
                     /translation="VDSLSYKTISANAATVTKEWVVIDATNEVLGRLASQVAKILRGKN
                     KPSYTPHVDCGDYVIVINAEKVKLTGNKMTDKVYTRHTGYPGGQRFATPADYLAKKPTF
                     LIEKAVKGMLPKTRLGDKLLSNLKVYAGAEHPHAAQNPKTIKLNEIK"
     CDS             complement(1399..2028)
                     /locus_tag="ctg36_4"
                     /transl_table=11
                     /translation="MGPGALTEPRKLILRFVVGKDGRVTPAPKPKYRDEDALEQTVRQA
                     IAAAPAWTPATIDGERVRFGVSMPVAFGPGAAGAEYSDKDAYRVVEVMPKFFGGGLDKF
                     RSWVMAEVRYPSDMLKRGVQGRVVAAFVVDKEGRITMVEILESPHPQFSEAVARVLGRA
                     PRWTPGRQDGALVRVEYTLPVDFKIRSELRFPSGAAGRNRGSSRSY"
     CDS             complement(2028..2594)
                     /locus_tag="ctg36_5"
                     /transl_table=11
                     /translation="MKRLFMVLFGLASLHAAATAAKTAGEEKTPGKNAGAAASLWPEKM
                     DPSFQGSRPECFKIWVIRNLRFPADRYDVGDEAKVEVVFAIDKNGTLTDLKVTHCEERH
                     FADRLCKTIALSPKWSPGRTKGKPVKTELEMRFVFRLVAPPAGQEELGLCAEECDIHTT
                     ADRMPLFCGAVRTGFVRGCSGRSTA"
     CDS             complement(2733..3944)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg36_6"
                     /sec_met_domain="OAD_beta (E-value: 5.4e-169, bitscore:
                     552.1, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MWNALTSSSNFVLESLETFAESTGVAGLIANMGWGSLIMICVAFF
                     LLYLAIKHKFEPLLLLTIAFGMLLTNLPGANLYHTELFAGGHVHWDIFVAQAGLLDYLY
                     LGVKLGIYPCLIFVGVGAMTDFGPLIANPKSFLLGAAAQLGIFLTFIGAYALGFSPAEA
                     GSIGIIGGADGPTSIYLTAILAPELLGPIAVAAYSYMALVPVIQPPIMRMLTTEKERKI
                     KMRQLRPVSKTEKILFPLIITVIIALLLPSAAPLVGCLMLGNLMKECGVVDRLSKTVQN
                     ELMNIVVIFLGLTVGATATAEAFLNPRTLFILVLGVIAFAMGTAGGVLLAKVMNFFSKG
                     DNKINPLIGSAGVSAVPMAARVSQTEGQKADPSNFLLMHAMGPNVAGVVGSAVAAGILL
                     SFLG"
     CDS             complement(3949..4410)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 71.2; E-value:
                     1.6e-22)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg36_7"
                     /sec_met_domain="Biotin_lipoyl (E-value: 5.6e-23, bitscore:
                     71.2, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKDYSLKINGHNYNVQIDDVNEASTVAHVVVNGVDYEVEIEGAKA
                     STVSKPQVSPAPKSANSAMITPSTATPSPRIAPAPSTSGSSVKCPLPGTVLSVKVAVGD
                     TVAAGQTLVVLEAMKMENNIDADRAGVVKQILVQQGATVMEGDVLIVIG"
     CDS             complement(4447..4767)
                     /locus_tag="ctg36_8"
                     /transl_table=11
                     /translation="MNWGWSEILWVSLIGFSLVFILLVALIFIMKAFGACFRVRPASGR
                     KVDAQPMISEEEIAAIATALKIYKGALHDRESEVLTILNIKRAYSPWNSKIHGLTQLPD
                     RR"
     CDS             complement(4798..6363)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Btheta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg36_9"
                     /sec_met_domain="CT_Btheta (E-value: 3.5e-286, bitscore:
                     939.8, seeds: 72, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSQIQEKINKLIENRETARLGGGQKAIDKQHDKGKYTARERIQML
                     LDEGSFEEFDMFVTHRCYDFGMDRKHTFGDGVVTGYGTIDGRLVYVFAQDFTVTAGSLS
                     LSMSDKICKVMDMAMRNGAPCIGMNDSGGARIQEGVNALAGYANIFQRNVMSSGVIPQI
                     SAIFGPCAGGAVYSPALTDFIIMKKETSNMFLTGPKVVKTVTGEDVTQEQLGGALMHTT
                     KSGVAQFAVDTEEEGIGLIKKLISYMPQNNMEDAPLAVCTDKITRLEDSLNEIIPDSAN
                     KPYDMTEVIKAIVDNGEFLESAAGYAKNIITCFARFNGQSVGIIANQPKFMAGVLDINA
                     SRKAARFVRFCDAFNIPIVTLVDVPGFLPGTTQEYGGVITHGAKLLFAYCEATVPKITV
                     TLRKAYGGAYIVMSSKHIRGDINYAWPTAEIAVMGASGAVEVLYGKELKELADKPEEKA
                     KFIAEKEQEYNDKFSNPYNAARYGYIDDVIEPRNTRFRVIRALQSLATKRLQNPAKKHS
                     NIPL"
     CDS             complement(6368..6778)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Glyoxalase_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg36_10"
                     /sec_met_domain="Glyoxalase_4 (E-value: 5.8e-27, bitscore:
                     84.8, seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKVSHIEHLGVAVKSLDEAIPYWENVLGLKCYAIEEVADQKVRTA
                     FFMLGQTKIELLEPTSEDSTIAKYIENRGVGIHHMALACENIEEQLADAEAKGIRLIDK
                     TPRKGAEGMTIAFLHPKSTQGILTELCENKNK"
     CDS             complement(6989..7978)
                     /locus_tag="ctg36_11"
                     /transl_table=11
                     /translation="MKIGLDTAPAALRGTYFQHLASVLARYAPEHEYIIGAEVNDGVDL
                     YHGFRSSLPLSVHLRRVPSVMTVPNLNFLRYPHLYTFAERLFVLTLYRRALRRAGRVIT
                     VSAPAREELSERLNIDPSKIEVMVPLAVPAPRGNPSQAELEHVRRKYALPEHFILMIGT
                     VEPRHNHQAVFAALADAASPAGVVVCGRRTAWSDYLLGYARARRIAARVDFIYELTPSD
                     LPALFRLARVFAYLPDADAEASVVPVVEALRAGLPMVLSDTQVNREAAGEAAAYVRPEA
                     RGEVLAALENALEDVSWRRTMQERERRRAELFSEYAVAERLMQIYTSL"
     CDS             8050..8514
                     /locus_tag="ctg36_12"
                     /transl_table=11
                     /translation="MKKVLLIWLLAAGFASAGATAQNIALGERVPELKIQTWLDNRQPE
                     PAPTTYIEFFHSTNPACKTSLERLKEITGKSGTKLRVIVVTKEDPAKIAPLLRPYLSER
                     ISVGLNAEKSFTAFGVSYLPFGVLTDAKNRTLWMGNSLQINEKLIEQSTR"
     CDS             8521..9645
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: MeaB"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg36_13"
                     /sec_met_domain="MeaB (E-value: 2.7e-101, bitscore: 328.5,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSFTRIDHYEKEYADTHHDTALNVTQGVEEQPIVSPYFKRRKKRA
                     LSTGEYVEGILAGNITTLSQAITLVESSNPNHYAQAQEIIEACLPHAGKSVRIGITGVP
                     GAGKSTFIEAIGNMVAGLRHKLAVLAIDPSSERSGGSILGDKTRMESICNNPSVFVRPS
                     PSAGSLGGVARKTRETIVLCEAAGFDVIFIETVGVGQSETAVHSMVDLFMLLQISGAGD
                     ELQGIKRGIMEMADLMVITKADGENIHKAELAQTQFQGALRLFPVPESGWRPKVYTSSA
                     VARTGLEEVWKGVEEYLDHIQKNGYFQHNRNRQNKYWMYESINEALRGSFYRDPAVEAC
                     IGAYEKRVLEDKISSFIAAKELLEIYFKDARTLE"
     CDS             9729..10568
                     /locus_tag="ctg36_14"
                     /transl_table=11
                     /translation="MKQGRFYLAAAILLLASGCEKEDGENTDDSKWTHPLTTTLHRTDP
                     GGEQSTYVITYTYDAKDRLTGTRNSRDGVTETTTSDYVYDGKTVTYTEKTWAGETLWNS
                     QKFKRTYLDDALEKVLEERITDKDDHIIQRICNEYDQQERLVHSLEYSRGNSKVSETKY
                     TYDGKLVICDKYWLKNTGEVSAVSKYIITYSDDELTKLLIHGCLAAEETAERPWDWVRH
                     YSYDYRGRLNGITYEAEGKLVWETRNYVYGNKSLTCENREVHYGTDIITISETTYKH"
     CDS             10867..12084
                     /locus_tag="ctg36_15"
                     /transl_table=11
                     /translation="MRSTFKVLFYLKRNKDKDQKVVPVMGRITVNGSIAQFSAKLSVPE
                     MLWEVSGGRAKGRSLEADRINRHLDNIRTQIGKHYQDICDRESYVTAEKVKNAYLGFGE
                     KYRLLLEAFEKFTGDLKKRVGIDRCHGTWNRYYKSIDHLRTFMRKEYNVSDMPLAELEQ
                     SFIEQYHVYLKSDLGLKPTTVSGYLKCLKYVVKIAFNNGWMPRTPFSLYQYTAPNPERS
                     FLTEDELRRMMTTELRYKRQDYNRDMFLFSCFTGICYADMASLTYDRIEQDAQGEWWIS
                     GNRQKTETKYVVKLLPYALFILNKYRGLTGDGRVFAMSTLDSIDDSLKNIARECGIDKQ
                     LSFHLARHTYATTICLSNGVSLETLSKMLGHKNITTTQIYAKVTPPMIDREVTMLREKL
                     ATKFSV"
     CDS             12115..12489
                     /locus_tag="ctg36_16"
                     /transl_table=11
                     /translation="MYLHTCINSLFGHCIFAAKTYCNPIMERLDEILEIIREIREDIAY
                     MKRHRNMLCGTPVLEVSEVCDLLKISDRQLRRYCVSGQLTGFHFGRRLMFSAAEINRFV
                     ERIDTECRQRKELKNRIRNL"
     CDS             12501..12830
                     /locus_tag="ctg36_17"
                     /transl_table=11
                     /translation="MPNKYYLVESGALEHLLRTHFLLTQSLLLFEHLLSHSDRPMFLSA
                     RKVCEVLGLDRHQLEQCRKKRMIRARTVNGQMMYDTYELLALTELFYRRKLRKTLSRIP
                     QFEVR"
     CDS             13121..13321
                     /locus_tag="ctg36_18"
                     /transl_table=11
                     /translation="MKNQKFEIAVAGYDYRFKTYARDGVEASVKVKCFLGRPDAECTIL
                     IPTLNDDLRETESCRRQVARR"
     CDS             13318..13971
                     /locus_tag="ctg36_19"
                     /transl_table=11
                     /translation="MRKWIDQSTFDELLLANAEDNIERAIQSASAVLEAVQEFVPEAAL
                     FYRVTHAADSLKNYFEEACTGFRRNGILFLVRKYTYPKTYYELRCDWSFFRYADNYSYG
                     KAFDKQTAPNRIGVFTKKKIDDWVEYLTQGFRNLERIDAENERKMTGYRNRLEALSDVV
                     WVHDKSHGQIIRNGLTYTFDIRQTDYSEKISLDYRCRTLDDFLALSDNKFTPKP"
     CDS             13978..14190
                     /locus_tag="ctg36_20"
                     /transl_table=11
                     /translation="MERNIIIENICTACRCGERRAEEYLTAELRNLRELRDAGALCYGD
                     LETACSGLGLDFDYTDYFCQALSLN"
     CDS             14203..14502
                     /locus_tag="ctg36_21"
                     /transl_table=11
                     /translation="MNNLCFNRFTLRTDDAKTRRKILRWLALNYRLYEYLPSEAEIRGR
                     FISRKPFPAEALRRQIGKLRGDRTLFLRIVSTDLYSLYVEGNVYLLGAWYRIFL"
     CDS             14551..14847
                     /locus_tag="ctg36_22"
                     /transl_table=11
                     /translation="MAYESSIPFADIRDFREAEINGISALFTMCRLDSETLPADFHSCE
                     VMGGRGSDFQWLVPLALANFTGTFVSRQPLLREGQAYAEIRRYGIYDATTVDEW"
ORIGIN
        1 atgccgttct tctccatgaa gatgtaagga gccattttgg ggttccattt gcgcttcagg
       61 tgaccgaagt gcgcaccggc ttccaataat gtattaaaat ctgtacgtga cattttaatt
      121 caattcgttg attaatttta attctctttt cttcaaccct ccgggtagcg gcctggccgg
      181 tcccggggag ttttccgcgg cgcggcaacc agatagtaga ctaattaaaa attaagaatt
      241 aaaaatgaaa aattcccaat atataataag tatccatgtg gtttgagaac cgtcgccgtg
      301 cgttgccgaa attccggtcg tgcgtattaa cgcttgctga actggaactt gcggcgtgca
      361 ccgggctgac cgggcttctt acgctcaacc tcgcgggaat cgcgcgtgag gaatccggcc
      421 ttcttcagca ccggacgcat ctccgcgtcg atttcgcaca gtgcgcgtgc gatgcccaga
      481 cgagcggccg aagcctgtcc cgtaatacca ccgccatcga ggttgatgac gatgtcgtaa
      541 ttctccgccg tgttggtggc cagcaggggc tgcttcacct ggtactggag aatttcgagc
      601 gggaagtaaa cttcaagcgc tttgcggttg attgtaatct gacccttgcc cggcttcacg
      661 tatacgcgag ccacagcggc cttacgacga cctacggtgt ttacaacttc cataactctt
      721 acttaatctc gtttaattta atagtcttcg ggttctgtgc ggcgtgagga tgctctgcgc
      781 cggcatagac cttcaggttc gacagcagct tgtcgcccag acgggtcttg ggcagcatgc
      841 ctttgacggc cttctcgatg aggaaggtcg gtttctttgc cagatagtcg gcaggcgtag
      901 cgaaacgctg gccgccgggg tatccggtgt gacgcgtgta gaccttgtcg gtcattttgt
      961 tgcccgtgag cttcaccttc tccgcgttga tgacgatgac gtagtcacca cagtcgacgt
     1021 ggggtgtgta gctgggcttg ttcttgcctc ggaggatctt cgcgacctgc gatgcaagac
     1081 gtcccaatac ctcgttcgta gcgtcgatca ccacccattc cttggtgacg gtcgcagcgt
     1141 tcgccgagat agtcttgtag cttaatgaat ccactgtttt tacgtttaat ttaacttatt
     1201 gtaatccgtt ccccgcacat tgcgggtgcg caaaggtacg aaaaagtttc tgatctgcaa
     1261 aaacaaatga aaatcaaaat cgaaaaccgc gcaaaaaaac cgcaacggcc ccgtattcag
     1321 gagagttgcg gcattccgaa gcaggagcgc ggcgttagcg ggcgcccttg gcaggcaggc
     1381 ggcaggcggg cggctgtgtc aatacgaacg ggatgaaccc cggttccggc cggcggcgcc
     1441 gctcgggaac cgcagttccg agcgaatttt gaaatcgacc ggcagcgtgt attccacccg
     1501 gacgagcgca ccgtcctgcc tgcccggcgt ccaccgcggc gcacgtccaa gcacgcgagc
     1561 gaccgcttcc gaaaattgcg gatgcggcga ctcgaggatc tccaccatcg taatccgccc
     1621 ctccttgtcg acgacgaatg ccgcgaccac acgcccctgc acgccccgtt tcagcatgtc
     1681 cgacgggtac ctcacttcag ccatcaccca actccggaat ttatccagcc cgcctccgaa
     1741 gaacttcggc atgacctcga ccacccggta agcgtcttta tcgctgtatt ccgctccggc
     1801 ggccccggga ccgaaggcga ccggcatcga gaccccgaaa cgaacccgct ctccgtcaat
     1861 cgtcgccgga gtccacgcag gagccgcggc aatggcctga cgcaccgtct gttccaaagc
     1921 atcctcgtcc cggtatttcg gtttgggggc aggagtcacc cgcccgtcct ttccgacgac
     1981 aaaccgcagg atcagtttcc gcggctccgt gagcgcaccc ggacccatca ggctgtcgac
     2041 ctgccgctgc acccacgcac gaaacccgtc cggaccgcgc cgcagaacag gggcatccta
     2101 tcggccgtcg tatggatgtc gcactcctcg gcgcaaagcc ccagctcctc ctgtcccgca
     2161 ggaggggcga ccagccggaa gacgaatcgc atctccagct ccgtttttac aggtttcccc
     2221 ttcgtccgtc cgggcgacca tttcggcgac agggcgatcg tcttgcagag ccggtcggca
     2281 aaatgccgct cctcgcaatg cgtgaccttc agatcggtca gcgtcccgtt tttgtcgatg
     2341 gcgaacacaa cttcaacctt cgcctcatcc ccgacatcgt agcgatcggc cggaaaccgc
     2401 aggttgcgga tcacccagat tttgaagcat tccggacggc ttccctgaaa agaggggtcc
     2461 atcttttcgg gccaaaggct ggccgccgca ccggcgtttt ttccgggggt cttttcctct
     2521 ccggcggttt tcgcggcggt cgcagccgca tgcagcgacg caaggccgaa aagcaccata
     2581 aacaagcgtt tcataataag gcaggagttt taggtttcat aaatatagcg aaaaatgcga
     2641 gacttgcaac ggcacaggcg caaaaaagag ggtccggcga accgaaaccc tcttgcaacc
     2701 gtatcgggcc gtgcggcccg gaacgcgatt ccctatccga ggaacgaaag cagaatgccc
     2761 gcggcgaccg ccgaaccgac cacgccggcc acgttgggac ccatggcgtg catcagcagg
     2821 aagttcgagg gatcggcctt ctggccctcg gtctgcgaca cgcgggcggc catcgggacg
     2881 gccgaaacgc cggccgaacc gatcagcgga ttgatcttgt tgtcgccctt cgagaagaag
     2941 ttcatcacct tggcgagcag cacgccgccg gcggttccca tcgcgaaggc gatcacgccc
     3001 agcacgagga tgaacagcgt ccgcggattg aggaacgcct cggccgtagc cgtagctccc
     3061 accgtgagac ccaggaagat gacgacaatg ttcatcagtt cgttctgcac cgtcttcgac
     3121 agacggtcca ccacgccgca ctccttcatc aggttgccca gcatgagaca gccgacgagc
     3181 ggagcggccg acggcagcag cagcgcgatg atcacggtga tgatcagcgg gaagaggatc
     3241 ttctcggtct tcgacaccgg acgcagctgg cgcatcttga tcttacgctc cttctcggtg
     3301 gtcagcatgc gcatgatcgg cggctggatc accggcacga gggccatgta ggagtaggcg
     3361 gccacggcga tcgggccgag cagctcggga gccagaatcg cggtcaggta gatcgacgtg
     3421 ggaccgtcgg cgccgccgat gatgccgatc gaaccggcct cggctggcga gaatccgagc
     3481 gcataagcgc cgatgaacgt gaggaaaata ccaagctgcg ccgcggctcc cagcaggaag
     3541 ctcttggggt tggcgatcaa cgggccgaag tcggtcatgg cgcccacgcc cacgaagata
     3601 aggcagggat agatgccgag cttcacgccc agatagaggt aatcgaggag tcccgcctgg
     3661 gcgacgaaaa tatcccagtg gacgtgcccc ccggcaaaaa gttccgtatg gtagaggttc
     3721 gctccgggaa ggttcgtcag cagcatgccg aacgcgatgg tcagcagcag cagcggttcg
     3781 aacttatgtt tgatggccag gtacagcaga aagaaggcca cacagatcat aatcagactg
     3841 ccccacccca tgttggctat cagaccggcc acgcccgtcg attcggcaaa ggtttcaagg
     3901 ctttccagca cgaaattgga gctggaagtc aatgcattcc acatagtcct acccgattac
     3961 gattaaaacg tcgccttcca tgaccgtagc gccctgctgc acgagaatct gcttcacgac
     4021 accggcgcgg tcggcgtcga tgttgttctc catcttcatg gcttcgagca cgacgagcgt
     4081 ctgtcctgcc gcgacggtat cgcccacggc caccttcacg ctcaacacgg tgcccggcag
     4141 cgggcatttc acgctggaac ccgacgtcga aggcgcggga gcgatgcgcg gcgaaggagt
     4201 ggccgtcgag ggagtgatca tggcgctgtt ggccgacttg ggggccgggg acacctgggg
     4261 tttggagacc gtcgaggctt tcgcgccctc gatctcgact tcgtaatcca cgccgttgac
     4321 cacgacgtgc gctaccgtcg aggcctcgtt cacgtcgtcg atctggacgt tgtaattatg
     4381 tccgttgatt ttcaaagagt aatctttcat tttctttttt gggttgtctt gttccgacgc
     4441 agggtcctat ctccggtcgg gaagctgggt taaaccgtga attttcgaat tccagggcga
     4501 ataggcccgc ttgatgttga gaatggtcag cacctcggac tcgcggtcgt gcagggcgcc
     4561 cttgtagatc ttgagcgccg tagcgatggc tgcgatctcc tcctcgctga tcatcggctg
     4621 ggcgtcgacc ttcctgccgc tcgccggacg gacccggaag caggccccga aggccttcat
     4681 aatgaagatc agcgccacta gcaggataaa caccaggctg aacccgatca gcgacaccca
     4741 gagtatctcg gaccatcccc agttcataac tgtcagtatt gtcatctttt cagtctgtta
     4801 gagaggaatg ttcgaatgtt tcttcgcggg gttctgcaaa cgcttcgtag ccagcgactg
     4861 caaggcgcgg atcacacgga aacgcgtgtt gcgcggctcg atcacgtcgt cgatatagcc
     4921 gtagcgtgcg gcgttgtagg ggttggagaa cttgtcgttg tactcctgct ccttctcggc
     4981 gatgaacttc gccttctcct ccggtttgtc ggccagctcc ttcagctcct tgccgtagag
     5041 cacctcgacg gcgccgctgg cgcccatcac ggcgatctcg gccgtcggcc atgcgtagtt
     5101 gatgtcgccg cggatgtgct tcgacgacat gacgatgtat gcgcctccgt aagccttgcg
     5161 cagcgtcaca gtgatcttcg gcacggtggc ctcgcagtag gcgaacagca gcttcgcgcc
     5221 gtgggtgatc acgccgccgt actcctgggt cgtacccggc aggaagcccg gaacgtccac
     5281 cagcgtcacg atcgggatgt tgaacgcgtc gcagaaacgc acgaagcgcg cagccttgcg
     5341 gctggcgttg atgtccagca cgccggccat gaacttgggc tggttggcga tgatgcccac
     5401 cgactggccg ttgaaacgcg cgaagcaggt gatgatgttc ttggcatagc ctgcggccga
     5461 ttcgaggaac tcgccgttgt cgacgatggc cttgatcacc tcggtcatgt cgtagggctt
     5521 gttggcgctg tcgggaatga tctcgttgag cgaatcctcc agacgggtga tcttatcggt
     5581 gcagacggcc agcggagcgt cctccatgtt gttctgcggc atgtaggaga tcagcttctt
     5641 gatcagcccg ataccctcct cctcggtgtc gacggcgaac tgcgccacgc ccgacttggt
     5701 ggtgtgcatc agggcgccgc ccagctgctc ctgcgtcacg tcctcgcccg tcacggtctt
     5761 cacgaccttc gggccggtga ggaacatgtt cgaggtctcc ttcttcataa tgatgaagtc
     5821 ggtcagcgcg ggcgaataga ccgcaccgcc tgcgcagggg ccgaagatgg ccgaaatctg
     5881 cggaatgacg cccgacgaca tcacgttgcg ctggaagatg ttggcgtaac cggccagggc
     5941 gttgacgccc tcctggatac gcgcgccgcc cgagtcgttc atgccgatgc agggcgcgcc
     6001 gttgcgcatg gccatgtcca tcaccttgca gatcttgtcg gacatcgaca gcgacagcga
     6061 accggccgtc acggtgaaat cctgtgcgaa gacataaacc agacgtccgt cgatcgtgcc
     6121 gtaacccgtc accacgccgt cgccgaaggt gtgcttgcga tccatgccga aatcgtagca
     6181 gcggtgggtc acaaacatat cgaactcctc gaacgaacct tcgtcgagga gcatctgaat
     6241 acgctcgcgg gccgtgtact tgcccttatc gtgctgtttg tcgatcgcct tctggccgcc
     6301 gccgagacgc gcggtttcgc ggttctcgat cagtttgttg atcttttcct gtatctggct
     6361 cataatccta tttgtttttg ttttcgcaaa gctccgtcag aatgccctgg gtcgatttcg
     6421 ggtgcaggaa ggcgatggtc atgccctcgg cgcccttgcg gggggtcttg tcgatcagac
     6481 ggatgccctt ggcctccgcg tcggcgagct gctcctcgat gttttcgcag gccagcgcca
     6541 tgtggtgaat gccgacgccg cggttctcga tgtactttgc gatcgtcgaa tcctccgaag
     6601 tcggctccag caattcgatc ttggtctgcc ccagcatgaa gaacgccgtg cggaccttct
     6661 ggtcggcgac ctcctcgatg gcatagcact tcaggcccaa tacgttctcc cagtagggaa
     6721 tcgcctcgtc gagactcttc acggcaacgc caagatgctc gatatgagaa actttcatag
     6781 caaaatttaa atttaagtta gtggatattc gtatgttgtt tcgttcgttg ttattttgcg
     6841 aacacaaaga tagacgaatc tttcagaacc gccaaaattc ggagtacttt ttttggcaat
     6901 aacttcgggt tcggaattcg caggaaatgt ccggaaaggc gattcgttcc ggcggagcct
     6961 ccggcggcct gcggtttgaa agccggggtt acagcgacgt gtaaatctgc atcagccgtt
     7021 ccgccacggc gtattcggag aacagttcgg cgcggcggcg ttcgcgctcc tgcatcgtgc
     7081 ggcgccacga cacgtcttcc aacgcgtttt cgagcgccgc gagaacctcg ccccgcgcct
     7141 ccggacgcac ataggcggcg gcctctccgg cggcttcgcg attgacctgc gtgtcgctca
     7201 agaccatcgg caaacccgcc cgcagggcct cgaccacggg gacgaccgac gcctcggcat
     7261 cggcgtcggg cagataggcg aagacccgcg ccagacggaa cagcgccgga aggtccgaag
     7321 gggtcagttc gtagatgaaa tccacccgtg cggcgatgcg gcgggcgcgg gcatagccca
     7381 gcagatagtc ggaccaggcc gtgcggcggc cgcagacgac caccccggcc ggggacgcag
     7441 cgtcggccag agccgcgaaa accgcctgat ggttgtgccg cggctcgacg gtccctatca
     7501 tcaatataaa atgctctgga agagcatact tgcggcgcac gtgttcaagt tccgcttgag
     7561 atggatttcc gcgcggagcc ggaaccgcca gcggcaccat gacctcgatc ttcgaagggt
     7621 cgatattgag gcgttccgac agctcctcgc gggccggagc gctgaccgtg atgacccggc
     7681 ccgcccgccg gagcgcacgg cggtagagcg tcaggacgaa aagccgttcg gcaaacgtat
     7741 agagatgcgg atagcgcagg aaattgagat tcgggaccgt catcaccgaa ggcacgcgcc
     7801 gcagatgcac ggacaacggc agcgacgacc taaagccgtg gtagaggtca acaccatcat
     7861 tcacctctgc gccaatgata tattcatgct ccggagcgta gcgcgccagc acgctggcga
     7921 ggtgctggaa gtaagtcccg cggagtgcgg cgggagccgt gtcgagtcct attttcataa
     7981 cttgattcta aaaaattggt ccatatgcca aataattgtt atctttatcg aataaaacaa
     8041 ggctctctta tgaagaaagt gctgcttata tggctgttgg ccgcaggttt cgcatccgcg
     8101 ggagccacgg cccagaacat cgccctcggc gaacgcgttc ccgaactcaa aatccagacg
     8161 tggctcgaca accgccagcc cgaaccggcc ccgacgacct acatcgaatt tttccattcg
     8221 acgaatcccg cgtgcaaaac ctcgctcgaa cgcctgaagg aaatcacggg caaatcgggt
     8281 accaaactgc gcgtgatcgt cgtgacgaag gaggaccccg cgaaaatagc cccgctgctg
     8341 cgcccctacc tctcggaacg gatctccgtg ggcctcaacg ccgaaaagag tttcacggcg
     8401 ttcggcgtca gctacctgcc gttcggcgtg ctgaccgacg ccaagaaccg caccctctgg
     8461 atgggcaatt ccctgcaaat caacgaaaaa ctgatcgaac aatcaacacg ctgacacacc
     8521 atgtcgttca ccaggataga ccattacgaa aaagagtacg cagacacgca tcacgacaca
     8581 gccctcaacg tcacgcaagg cgttgaagaa caaccgatag taagccccta cttcaagcgg
     8641 cgcaagaagc gcgctctctc caccggagag tacgtcgagg gcattctcgc gggcaatatc
     8701 accaccctct cgcaggccat cacgctcgtc gaatcgtcaa accccaacca ctatgcacag
     8761 gcgcaggaga tcatcgaagc gtgcctcccg cacgccggga aatcggtccg cataggcatc
     8821 acgggcgtcc cgggagccgg caaatcaacc ttcatcgaag ccatcggcaa catggtcgcg
     8881 gggctgcgcc acaagctggc ggtgctggcc atagaccctt cgtcggagcg cagcggcggc
     8941 tcgattctcg gcgacaaaac ccgcatggag agcatctgca acaacccttc ggtcttcgtg
     9001 aggccctcgc cctcggcggg atcgctcggc ggagtggccc gaaagactcg cgagacgatc
     9061 gtgctgtgcg aggccgcggg attcgacgtc atcttcatcg aaacggtggg cgtcggacag
     9121 tcggaaaccg ccgtgcactc gatggtggac ctcttcatgc tattgcagat ttccggtgcg
     9181 ggagacgaac tgcaaggcat caagcgcggc atcatggaga tggccgacct gatggtcatc
     9241 accaaggccg acggagagaa catacacaag gccgaactgg cacagaccca gttccagggg
     9301 gccttgaggc ttttccccgt acccgaatcg ggatggcggc ccaaggtcta cacctcgtcg
     9361 gcggtggccc ggacggggct ggaggaggtc tggaaaggcg tggaggagta cctcgaccac
     9421 attcagaaaa acggctattt ccagcacaac cgcaaccggc agaacaaata ctggatgtac
     9481 gagtcgatca acgaggcgct gcgcggaagt ttctaccgcg acccggccgt ggaggcgtgc
     9541 atcggagcgt acgagaaacg cgtgctggag gacaaaatct catcgttcat cgccgccaag
     9601 gagttgctgg agatctattt caaggacgcc cggacgctgg aatgacccgt gtcacagtcc
     9661 ggcgggcggg ttgccggcag gtggatatgc ccataataca gcccttataa tcgttaaaat
     9721 ttcgagccat gaaacaagga cgcttttacc tggctgcggc gatattgctg cttgcttcag
     9781 gttgtgaaaa agaggacgga gagaacacag acgactctaa atggacacac ccgctgacaa
     9841 cgacccttca cagaaccgat cccggaggag agcagagtac atatgtgata acgtacacct
     9901 acgacgcaaa agatcggctg accggaaccc ggaactcgag agacggcgtt acggaaacga
     9961 caacttcgga ctacgtatat gacggcaaaa cggtgacata cacggaaaaa acatgggccg
    10021 gtgaaaccct gtggaattcg caaaaattca aacgcactta tctggatgac gctctcgaaa
    10081 aggttttgga agaacggata acggacaagg acgaccatat catccaacgg atttgcaacg
    10141 aatacgacca gcaggaacgg ctggtccaca gtttggaata ttccagaggg aatagtaaag
    10201 tatccgaaac aaaatacacc tacgacggaa aactggtaat ctgtgacaaa tattggctca
    10261 agaatacagg cgaagtatcg gctgtaagca aatacataat cacatactcc gacgatgaac
    10321 tgacgaaact gcttattcac ggctgtctgg ctgccgaaga aacggccgaa cgcccatggg
    10381 attgggtaag acattacagt tacgattacc ggggacgcct caacggaatt acgtacgaag
    10441 cggaaggtaa gctcgtctgg gagacccgca actacgtata tgggaacaaa tccctcactt
    10501 gcgaaaaccg ggaggtgcat tatggcacgg atattataac catatctgaa acaacctaca
    10561 aacactgaca ccgatctccg gcaaaacagc cccgccctcc cggagatttc cggggataaa
    10621 aaacagaggt gtaaaaaagt gtaaagcaaa agataatcaa ataattatac acttttcttc
    10681 agtgcctttg ttttagagaa aaagtagaat aaggtaatgt taaacgaggt ttcggtttcc
    10741 aaatcgttac ctcgtttctt tcgctctatt attcatagaa acgtgatttt cagtttcttg
    10801 catcgttatt catcttgaca tacgactctg ctgaaattat ttttgcaacc ctaaaaagca
    10861 gagtttatgc gcagcacgtt caaggttctg ttctacctta aaaggaacaa agacaaagat
    10921 cagaaagtcg tccctgtcat gggtcgcatc acggtcaacg gcagcatcgc gcagttcagc
    10981 gcgaagctct ccgttccgga gatgctttgg gaggtcagcg gcggccgcgc caaaggccgc
    11041 agcctcgaag cggatcgcat caaccgtcat ctggacaaca tccgcaccca gatcggcaag
    11101 cactatcagg atatctgcga ccgggagtca tacgttacgg ccgaaaaggt caagaatgcc
    11161 tatctcggct tcggagagaa ataccggctg cttctcgaag cgttcgagaa attcaccggc
    11221 gacctcaaga aacgtgtcgg catcgaccgc tgccacggta catggaaccg ctactataaa
    11281 tccatcgacc atctgcggac tttcatgcgt aaggagtata acgtgagcga tatgccgttg
    11341 gcggagttgg aacagtcgtt catcgagcaa taccacgtct accttaaatc cgatctgggg
    11401 ctcaagccta cgaccgtcag cggttatctc aaatgcctga aatacgttgt caaaatcgcg
    11461 ttcaacaacg gctggatgcc tcgcaccccc ttttccctct atcaatatac ggctccgaat
    11521 ccggaacgta gttttttaac ggaagatgaa ctccggcgta tgatgactac cgagctgcgg
    11581 tataagcgtc aggactataa ccgcgatatg ttcctgttct cctgcttcac gggcatctgc
    11641 tatgcggata tggcctcgct gacctatgac cggatcgagc aggatgcgca gggcgagtgg
    11701 tggatcagcg gcaaccgcca gaagaccgaa accaaatacg ttgtcaagtt gctgccttat
    11761 gcgttgttca tcctgaacaa gtatcggggt ctgaccggcg acggacgtgt ttttgccatg
    11821 tctacactcg attcgatcga cgacagcctg aaaaacatcg cccgggagtg cggcattgac
    11881 aaacaactct cattccacct tgcccggcac acgtacgcca cgacgatctg cctgtcgaac
    11941 ggcgtgagtc tggagacgct ttcgaagatg ctgggacata aaaatatcac caccactcaa
    12001 atctatgcga aagtcacccc gccgatgatc gaccgtgagg ttaccatgct ccgggagaaa
    12061 ctggcaacga aattctccgt gtagacactt tgcaataaag tatataaata tattatgtat
    12121 ttacatactt gtatcaactc attattcggt cattgcatct ttgcggcgaa aacctactgc
    12181 aacccgatta tggaacgact cgatgagatt ttggaaatca ttcgtgagat ccgcgaggat
    12241 atcgcctata tgaaacgtca ccggaatatg ctttgcggta cgccggtcct tgaagtgagc
    12301 gaggtctgcg acctgctgaa gatcagcgac cgtcagttgc gccgttactg cgtcagcggt
    12361 cagctcaccg ggttccactt cgggcgccgt cttatgttct ccgctgccga gataaaccgt
    12421 tttgtcgagc ggatcgacac ggagtgccgg cagcgaaaag aacttaaaaa ccggatcagg
    12481 aacctttaat tcataaccct atgcctaaca agtattattt ggtggagtcc ggagccttgg
    12541 agcacctgct ccgcacgcat ttcctgctga cacaatccct attgctcttc gaacacctgt
    12601 tgagccacag cgaccgcccg atgttcctct cggcccgcaa ggtctgcgag gtgctgggtc
    12661 tggaccgtca ccagctcgaa caatgccgca aaaagcggat gatccgcgcc cgtaccgtca
    12721 acggacagat gatgtacgat acctacgagt tgcttgcgct tactgaactt ttctaccgcc
    12781 ggaagctgcg gaagaccctc tcccggatac cgcagttcga ggtgcgctga tccgttcgtg
    12841 ctgaaaggga ctgactgcat ccgcagcagt ctctttttgt tttgagacag cacgaataat
    12901 aattaaaaat ccctttgtga acgccggcct cggggcaaga tagcgccgga cacgttccgg
    12961 cgtcaaattt ttgcggcacg atctccaccc ttcgggtcgt atcgcccctc aaaaatttgc
    13021 cttgtccgtg ccgtcgctga atatcccgcc ccgaagccgg cttctctctt tcatagcggg
    13081 gatctgccgg ccttatgtca aactaaaatc catttcgaat atgaagaatc agaaattcga
    13141 gattgcggta gcgggttacg actaccgttt caagacctac gcccgggacg gcgtggaggc
    13201 atcggtaaag gtgaaatgtt tcctcggacg acccgatgcc gagtgtacga tccttattcc
    13261 gacgttgaac gacgacctgc gggaaactga atcctgccgc aggcaggtgg cccggcgatg
    13321 agaaagtgga tcgatcagtc gaccttcgac gagctgctgc tcgccaatgc cgaggataac
    13381 atagagcggg ctattcaaag cgcatcggcc gtattggaag cggtgcagga gttcgttccg
    13441 gaggcagcct tgttctatcg tgttacacac gccgcagaca gcctgaagaa ctatttcgag
    13501 gaagcctgca ccggtttccg caggaacggt atcctgtttc tcgtccgcaa atacacctat
    13561 ccgaaaacct attacgagct ccgttgcgat tggtcgttct tccgatacgc ggacaactac
    13621 tcctacggca aggctttcga caaacaaacc gctccgaacc gtatcggggt cttcaccaaa
    13681 aagaagatcg acgactgggt ggaatacctc acgcagggtt tccggaatct cgaacggatc
    13741 gatgcggaga acgaacgcaa aatgaccggg taccgcaacc ggttggaggc tctgtccgat
    13801 gtggtttggg ttcatgacaa aagtcacggc cagatcattc gtaacggtct gacctatact
    13861 ttcgatatcc ggcagacgga ttacagcgaa aagatctctt tggactatcg gtgccgcacg
    13921 ctcgacgatt tccttgcact ctccgacaat aaattcacac ctaaacctta aacgactatg
    13981 gaacgaaaca ttattatcga aaatatctgc actgcgtgcc gctgcggcga acgtcgcgcc
    14041 gaggaatatt tgaccgcgga acttcgcaac ctgcgggaac tgcgggatgc cggggctctg
    14101 tgctacggcg atcttgaaac ggcctgttct gggctgggac tggacttcga ttatacggac
    14161 tatttctgtc aggccttgtc actgaactaa ctccgattta cgatgaacaa tctttgtttc
    14221 aaccgtttca cactgcggac ggacgatgcg aaaacccgcc gtaaaatcct tcgctggctg
    14281 gcgctcaatt accgcttgta cgaatacctc ccctcggagg cagagatccg cggacggttc
    14341 atctcgcgca aaccctttcc cgccgaagcg ctccggcgcc agatcgggaa actgcgcggc
    14401 gacaggactc tgttcctgcg gattgtctct acggacttat actcactcta tgtggaaggt
    14461 aatgtctatc tgctcggggc gtggtaccga atctttcttt aataacctgc cgcctgctcc
    14521 gcaacgagcg ggcggcgtca tttccatatc atggcatacg aatcatccat tcctttcgcg
    14581 gatatcaggg atttccgcga ggccgagatc aacggcatct ctgctctttt cactatgtgt
    14641 cgcctcgatt ccgaaaccct tcccgccgat tttcattcgt gcgaggtcat gggcggtcgg
    14701 ggcagcgatt tccagtggct cgttccgctg gctttggcaa acttcaccgg aacgttcgtc
    14761 tcccggcagc ccctgctccg ggaaggacag gcgtacgctg aaatacgccg gtacggcatc
    14821 tatgacgcga cgacagtcga cgaatgg
//
