LOCUS       gnlProkkaGMCKDHEM_37   22758 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|GMCKDHEM_37.
ACCESSION   gnlProkkaGMCKDHEM_37
VERSION     gnlProkkaGMCKDHEM_37
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 20:01:24
            Original ID  :: gnl|Prokka|GMCKDHEM_37
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 22904
            Orig. end    :: 45662
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..22758
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:12758]"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12758
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
     cand_cluster    1..22758
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(HMGL-like and AMP-binding)"
                     /kind="single"
                     /product="betalactone"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..22758
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="betalactone"
                     /region_number="1"
                     /rules="(HMGL-like and AMP-binding)"
                     /tool="antismash"
     CDS             410..1246
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     135.3; E-value: 4.2e-41)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg37_24"
                     /transl_table=11
                     /translation="MNTAIVKRAFRYIFRGIPRPHISIAVKNFTTRRLEGRKILITGGG
                     KGIGYWIAKKCVSEGAKVLICGRQEETLRRACRELGESCQYIKFDVSSIIDIPSFLNEA
                     FLRMNGIDSLVSNAGISLHEGSFKNVTESGFDAQFKVNFKAPYFLAKYFVEKIENEKID
                     FANILFVTSERGSFCTSIPYGLTKASLKNYVGALCRYYCFNERIRVNAIAPGVTSSEMT
                     GYSENGDFQTDDSPNGRIFHPAEMANVACFLLSDEASCISGETIHCDFGRHQSVID"
     CDS             1434..2111
                     /locus_tag="ctg37_25"
                     /transl_table=11
                     /translation="MSKISHSPVAIIVEEAYLPNTYTALTEAWLQRVQVIVLALNSMNL
                     DSSFYLNRCVDASILIDNVETIEGVVCNAIQHHGPSLIKIKEEVNEEKKIDYTNLFSII
                     DLCAKDKKVLCYNPQYGNKDYEFIPPEYKYGVISKYVGQLIGGKQSVLCIPEYLLALDT
                     NIFNFRDFPDGFKLIVKYSDGVCWGRLNTWMQRNNINTYVVDGRSFEYTTMNFKPNYAI
                     LVK"
     CDS             2117..3850
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 58.5;
                     E-value: 8.5e-18)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg37_26"
                     /sec_met_domain="TPP_enzyme_N (E-value: 2.3e-23, bitscore:
                     75.4, seeds: 75, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTKIKQVQQIVSLLKQNNIRHFVLSPGTRHVAFVHIVEMDPFFR
                     CYSIVDERSAAFFALGLSEALDEPVGFACTSATASCNYMPAMKEAYERNIQLVALTSDK
                     QRYQRFHGVSQVINQVDMFAPYCRYAVDLPEVNDSMDEWFCNRCINEALLEMDHHGRGP
                     IQINFLEPSSIDELSIFYDGNMPVCRKINRIEDWSQINEWKNVLAAKKRILVVCGQYQE
                     FTGCLRSSIRKFYEKYNCAVSFDAFSNVADKDFIQTMLLSITLNQKELLSLKPDLIITF
                     GTKYFSDIVSRFAGMGIEHWEINFEGRIFDTSRSLTKIFEFTPEEFFDKVSYNITTNDK
                     QYDKLWRALNESRDNSIDEFTNYYVAKKVLESLPEGSNVHASVLNSMKFTNMSKLPQNT
                     IATGNNCADGIDGALSTFIGQAEVLDSLSLLVIGDLSYLYDLNAAIHDFKNNTRVLLIN
                     NFAGGEFHFNIGKKKISTLEQHIAAGHHTKIQDAISLSNFQYIAVHNKGELEEKLSLFL
                     RESENPILMEVFTNPELDGSSLKKLIRNNIKMTPERLIAGFVNKFLDCRTKYAIKKFLH
                     R"
     CDS             3883..4986
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1045:glycosyl transferase group 1 (Score: 95.6;
                     E-value: 6.3e-29)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg37_27"
                     /sec_met_domain="Glycos_transf_1 (E-value: 2.8e-26,
                     bitscore: 84.9, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVLIYGFTGNVLGGIEVYTLNMSEYMSDDCVFDYIVDGDECAYR
                     ERITKRGGKIFFVPWVRRHPLGYINKLWRIFGEEKKSGTNILYHQLFTMSNLIPDVIAK
                     LRGYKVILHAHNNGLQKGGRMYLMAHNLGKILSRFCGFVMFTNSQLSSDYMFGKGVNSK
                     LIYNAIDVGKFAFKQEHRDCIRKELDCQSKTVIGFVGRLVDQKNPLFMLKVFAEIHKLR
                     PNSELWIIGEGILRGKMEVEINEQGICSSVKWLGRREDVNRLMQGMDLLLQPSVFEGLG
                     IVLVEAQATGLAVVSSEVVIPKEAVISDRIKLLPLSEKPAYWAAESVNLLDSCCESYDR
                     TNAIVPDCYNIQHEAKRLESMLKELIS"
     CDS             4991..6160
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Wzy_C"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg37_28"
                     /sec_met_domain="Wzy_C (E-value: 1.1e-07, bitscore: 24.7,
                     seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIIPVKTSKWFTYYLLFLPLVMMYSVPGTGIRIPTLLTAIAMLYS
                     LLQLANRHMRVPIYMLLPLFMYLTYVMFKSSLQLAFLCGSVIIIISAICTGIVNVFLLR
                     KVLEKVAIVAAFCVIFQQIVHILTGIHFHFYLLPFFANDLLEQYNNAITTGAVEGMYRP
                     CAFFLEPAQYSQYCTIGLGSCLFTHRPKTKNALFISLGIFASTSGMGFVSVFAIWGAWA
                     LSRQKTKKNFIRSLPVILIALFLVFFLLDNISFTHNIINRFTSTSGDDYNAINGRLFWW
                     DTYFGDFNISDFLTGFGLDNLPDGVYFTGFMKLLYCYGLIGTTLLLLFLGMLIIKADIF
                     VKVCTSLYTGLLFFADLTYYHNLIFYIGVYLALYIFNKERVNIAGTLKA"
     CDS             6176..6586
                     /locus_tag="ctg37_29"
                     /transl_table=11
                     /translation="MDKNNSFNLRAWLWGKMTSLYPKYLKWHFKMDIGENAVIARTAVL
                     DKNINPQGIHIGKNTWVLRDAIILAHDHCRGKNGKGRLFDTRIGKNCVIGIRSIILPGV
                     TVGDHCVVAAGAVVTKNAPPQLHNSRQSCGSY"
     CDS             6647..7255
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Bac_transf"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1146:sugar transferase (Score: 240; E-value: 8.8e-73)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg37_30"
                     /sec_met_domain="Bac_transf (E-value: 1.5e-63, bitscore:
                     206.2, seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYKHFFKRPFDFIISLVALICLSPILLAVTIWLHFANKGAGAFFI
                     QARPGKDAEIFKVIKFKTMKDEFDEKGEPLPDEVRLTKVGKIVRSTSLDELPQLLNVLK
                     GDMALIGPRPLMPEYLELYTPEQMRRHEVRPGITGWAQIHGRNELPFTERFEYDVYYVD
                     HLTFGLDLKIFFMTIVKIFKREGISQKGQATVETFDGTN"
     CDS             7270..7905
                     /locus_tag="ctg37_31"
                     /transl_table=11
                     /translation="MKHLVIIGGGGMGKDIYHSAKHSIGYGTEYDIKGFIDDNLNSLDG
                     CEGYPPVLDTIKNYQPSEDDVFTCSIGNVKTKRTLCEMIKDRGGKFITLLHETAQLGEN
                     VKLGDGCIIDSHAHIGSDTIIGENCLVQTFAGIGHDCRVGDYCRIDVRAFLVGGVRIEE
                     NVTIHTNAILNHHVVVEKDAVVAALSFVVRKVKAGTTVFGNPAKLLKY"
     CDS             7942..8172
                     /NRPS_PKS="Domain: PP-binding (6-70). E-value: 1.6e-08.
                     Score: 26.8. Matches aSDomain:
                     nrpspksdomains_ctg37_32_PP-binding.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg37_32"
                     /sec_met_domain="PP-binding (E-value: 3.1e-08, bitscore:
                     26.8, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MELNEFIENFAEQFDDTDASEIKADTVFKELDEWSSLVALSVIAM
                     VDEEYDITIKGDEIWNSNTVEDLFNAIKAKA"
     aSDomain        7960..8151
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg37_32_PP-binding.1"
                     /evalue="1.60E-08"
                     /label="ctg37_32_PP-binding.1"
                     /locus_tag="ctg37_32"
                     /protein_end="70"
                     /protein_start="6"
                     /score="26.8"
                     /tool="antismash"
                     /translation="IENFAEQFDDTDASEIKADTVFKELDEWSSLVALSVIAMVDEEYD
                     ITIKGDEIWNSNTVEDLFN"
     CDS             8178..8924
                     /NRPS_PKS="Domain: PKS_KR (10-168). E-value: 1.3e-10.
                     Score: 33.3. Matches aSDomain:
                     nrpspksdomains_ctg37_33_PKS_KR.1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     177.9; E-value: 4.1e-54)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg37_33"
                     /transl_table=11
                     /translation="MYNPYSLTGKTILVTGASSGIGRATAIECAKLGAKVVITARNEDR
                     LKETLDTLEGEGHQMICFDLSETEKLNDFVASLPPVQGFVSNAGTTIIAPIKFIKEDSL
                     EGLLQVNTVSPILLLQRLLKKRILGKGSSVVFTSSMAALGKGTPGNTMYSASKGAISAF
                     IQNAALELSAQRIRVNAVCPGTVDTPLIHSGGITDEQLSEDAKKYPLGYGQPEDIALGI
                     AYLLSDAAKWVTGTNVIIDGGLSVSC"
     CDS_motif       8208..8300
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg37_33_0001"
                     /evalue="9.80E-05"
                     /label="PKSI-KR_m1"
                     /locus_tag="ctg37_33"
                     /protein_end="41"
                     /protein_start="10"
                     /score="15.0"
                     /tool="antismash"
                     /translation="TILVTGASSGIGRATAIECAKLGAKVVITAR"
     aSDomain        8208..8681
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg37_33_PKS_KR.1"
                     /evalue="1.30E-10"
                     /label="ctg37_33_PKS_KR.1"
                     /locus_tag="ctg37_33"
                     /protein_end="168"
                     /protein_start="10"
                     /score="33.3"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="TILVTGASSGIGRATAIECAKLGAKVVITARNEDRLKETLDTLEG
                     EGHQMICFDLSETEKLNDFVASLPPVQGFVSNAGTTIIAPIKFIKEDSLEGLLQVNTVS
                     PILLLQRLLKKRILGKGSSVVFTSSMAALGKGTPGNTMYSASKGAISAFIQNAA"
     CDS             8941..9999
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) fabH"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1084:3-oxoacyl-(acyl carrier protein) synthase III
                     (Score: 204.7; E-value: 3.1e-62)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg37_34"
                     /sec_met_domain="fabH (E-value: 2.3e-50, bitscore: 164.3,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAKIKINNVRIKGIAACAPSKVEENSEYPYFDENEFENIIPSIGV
                     ERRHVAKEGQTCADFAQRAAEKLMEELGWEKESIDLLIFGSPSKDYIQPDTACVLQGKL
                     DLPESCMAFDMTLGCTGWTYGMTNACSLMQTGCIKRVLLLNGIQGSAESCYYDKTGYPL
                     FSDVATATALEYDPTAAPIYCELGTIGKQFDAILVPDGGRRNPVTEGSLKLVEYEKNVK
                     RNRLHTFMKGMDVFSFALKTAPKSTNAVLEFAGKEKDEIDYFFFHQANFYMVKKIIKKL
                     KIDPEKAPIVMKDFGNTGACSIPFTMVIGCAEKLRNGKHTNVGCSFGVGLSWGSLCFET
                     ENLVIPELQIYD"
     CDS             10001..11533
                     /NRPS_PKS="Domain: AMP-binding (9-409). E-value: 1.8e-80.
                     Score: 262.4. Matches aSDomain:
                     nrpspksdomains_ctg37_35_AMP-binding.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     313.9; E-value: 2.6e-95)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg37_35"
                     /sec_met_domain="AMP-binding (E-value: 1.6e-83, bitscore:
                     273.3, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRSQLADLFYKNAAEMPDKQAIWCDGKTATYQEMANRVSRYSNYL
                     VAKGVQYGDHVAIPMNNSIESVALFFSAADLGVCLVPLNPTLPLESIKVAMKSGDMKHL
                     IARKSFLNECEKKGGVDVPGITVCLDGEFEGAFPFSEVATMPTTRPACENIKGDESLIL
                     TMTSGSTGTPKPIDISQQNKIDRSLAHIRVYGLVKEDRILAATPLYHSLAERLVIMPLL
                     LGATSILLPRFTPALWLKCAAEQKPTFTIAVSAQLAQILELLKQENTESIDSFHTIVSS
                     SALLEEKVKLELIDRLQCEFHEMYGTSETSTATDICFQKARNKQKSVGLPFDEAEVKIL
                     RDDEDTECAVGEVGEIAVKSKLTCKGYYKLKNMMDMATTEGFFRTGDLGYMDEDGYLYF
                     AGRKKELIITGAINVYPNDVDAVVNQLTAVEECAAFSYPDERLGEVVALAVVVKEDCEL
                     TERTIQTYCAKNLADFQQPHKIFFVDMLPKNTMGKLQRNRILDHIRNVGIDK"
     aSDomain        10028..11227
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg37_35_AMP-binding.1"
                     /evalue="1.80E-80"
                     /label="ctg37_35_AMP-binding.1"
                     /locus_tag="ctg37_35"
                     /protein_end="409"
                     /protein_start="9"
                     /score="262.4"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="YKNAAEMPDKQAIWCDGKTATYQEMANRVSRYSNYLVAKGVQYGD
                     HVAIPMNNSIESVALFFSAADLGVCLVPLNPTLPLESIKVAMKSGDMKHLIARKSFLNE
                     CEKKGGVDVPGITVCLDGEFEGAFPFSEVATMPTTRPACENIKGDESLILTMTSGSTGT
                     PKPIDISQQNKIDRSLAHIRVYGLVKEDRILAATPLYHSLAERLVIMPLLLGATSILLP
                     RFTPALWLKCAAEQKPTFTIAVSAQLAQILELLKQENTESIDSFHTIVSSSALLEEKVK
                     LELIDRLQCEFHEMYGTSETSTATDICFQKARNKQKSVGLPFDEAEVKILRDDEDTECA
                     VGEVGEIAVKSKLTCKGYYKLKNMMDMATTEGFFRTGDLGYMDEDGYLYFAGRKKELII
                     T"
     CDS_motif       10490..10534
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg37_35_0001"
                     /evalue="8.60E-04"
                     /label="NRPS-A_a3"
                     /locus_tag="ctg37_35"
                     /protein_end="178"
                     /protein_start="163"
                     /score="12.4"
                     /tool="antismash"
                     /translation="TMTSGSTGTPKPIDI"
     CDS             11549..11800
                     /NRPS_PKS="Domain: PP-binding (29-72). E-value: 7.4e-07.
                     Score: 21.5. Matches aSDomain:
                     nrpspksdomains_ctg37_36_PP-binding.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg37_36"
                     /sec_met_domain="PP-binding (E-value: 1.4e-06, bitscore:
                     21.5, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDIKEFVTEYIQREYTVPEDVDIMTLNYIEAGYIDSMAFIQFIS
                     TIEDEYDIEFEVEDIENPKLRIVGKLIDFIQAKIDEQH"
     aSDomain        11636..11764
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg37_36_PP-binding.1"
                     /evalue="7.40E-07"
                     /label="ctg37_36_PP-binding.1"
                     /locus_tag="ctg37_36"
                     /protein_end="72"
                     /protein_start="29"
                     /score="21.5"
                     /tool="antismash"
                     /translation="IEAGYIDSMAFIQFISTIEDEYDIEFEVEDIENPKLRIVGKLI"
     CDS             11808..12758
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: HMGL-like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1271:2-isopropylmalate synthase (Score: 93.1; E-value:
                     3.2e-28)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg37_37"
                     /sec_met_domain="HMGL-like (E-value: 5.8e-24, bitscore:
                     77.8, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRNIEGIKIVDATIRDGGLVNDFFFTDEFVKKVYETNVAAGVDYM
                     EFGYRADKKMFDPSKFGKWKFSSDEDIFSIVGDNPTGLKLCVMADVGRCDFKNDIHKKS
                     DSPLSLIRVATYIETFSEAIEMIEFAAKQGYEVTCNLMAISKCTMMQLSKALDALAQTP
                     VMGVYIVDSYGALYPKEVRKLTRHFQDHLSPYGKLTGIHAHNNQQCAFANTIEAHDLNA
                     KMLDATYYGMGRGAGNCHLEALLGYFNGKKYHVEPVLDLVGSDMLVMKDQEPTWGYNTS
                     YLIAGLANAHPRDAIAATKKKDTNFVEQYKFQIYK"
     CDS             12806..13120
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DHQ_synthase"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg37_38"
                     /sec_met_domain="DHQ_synthase (E-value: 7.1e-14, bitscore:
                     44.3, seeds: 76, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGQGVIADLPRLVEPFCKGGKVGVITDDTVDALYAAKAVWAMEQY
                     GYDVCKYVIPYGESSKNINTLSGILEYFASCHFTRKDIFLSIGGGVIGDITGVPAALYM
                     "
     CDS             13160..13564
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DHQ_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1183:3-dehydroquinate synthase (Score: 110.7; E-value:
                     1.2e-33)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg37_39"
                     /sec_met_domain="DHQ_synthase (E-value: 1.6e-47, bitscore:
                     154.6, seeds: 76, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVDASISGKTAVDLQAGKNLIGAFWQPSLVVADTQVVTNLPADIF
                     AEGMAEVIKSDLIANAGIVEMIRQNTIKERIDQMVASCIKMKRDVVEQDEYETKGLRKV
                     LNMGHTVPHAIEKLSNYSISHGVAVATGLV"
     CDS             13822..15003
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1079:oxidoreductase (Score: 76.5; E-value: 3.9e-23)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg37_40"
                     /transl_table=11
                     /translation="MEQVTIGMAGAGRATELHIMALKRFLGVPVRLKTIVARRKEQLEE
                     AQRLYGFEQISYSFDDMINDPEIDVIDICTPPYAHEEMIEKAMMAGKHVICEKPLTGYF
                     GTPGDEEPIGDKVPKRVMYLKMLEQIRYLRTVIKKTGKKFMYAENFVYAPAVRKTAEII
                     KAKKSRILFMKGEESLKGSSSPVAGEWSKTGGGTMIRTGAHPLSAILWLKQQEAQARGV
                     EIKVKSVLGVMDRITPQLNEYEHRHIAARPHDVEDFGTIILDFTDGTKAVVIATDTLLG
                     GSKNYVELYCNDAAINCNLTMSNLMSTYFLDEDNLDDVYISEMLPSKTGWNNPFLEDEI
                     IRGYTDEMRDFMECVYYDREPQSGFTLAYDTIKIIYAAYMSAELGNKVELNAF"
     CDS             15006..16040
                     /locus_tag="ctg37_41"
                     /transl_table=11
                     /translation="MDFLKKLPTPEELAKIYPLSKGMAKKKLEHDKEIKKIFSGESKRL
                     LLNIGPCSADRMDAVLEYAARLAEIQKEVVENILIVPRVYTSKPRTIGKGYMGMIHQPY
                     IGQGEDLSMGVAAVRNVHRQVVEETGLFPSDELLYPETIHYLADLLGYAVIGARSVENQ
                     QHRLVASGLNIPVGLKNPISGSINVMLNAIETAQHPHHFIFNGWEVMSKGNEYAHGVLR
                     GYLEEGGAATRNCDYEHLSEICDRFAVRNVENPAVVVDCNHSNSDKQYMRQIDNAMEVL
                     GLMKEYPKIKKLVKGLMIESYLEDGNQPIDGGVYGKSVTDPCLGWEKSKQLIYDINEKL
                     EGLK"
     CDS             16037..16252
                     /locus_tag="ctg37_42"
                     /transl_table=11
                     /translation="MSERPKKIFCFDNYPEAKMVLGKVTYPVIIKPYECEDKTFWFEAS
                     DYGKAGQVLYDAFEHTRNGWVMIEEH"
     CDS             16228..16953
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1170:metallo-beta-lactamase family protein (Score:
                     98.8; E-value: 5e-30)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg37_43"
                     /transl_table=11
                     /translation="MGDDRGTLSMNSYKAFIEEREVSIYRFPYELVDSNMFFIPSGDTG
                     IVFDPNENEELLRVFQELGTRSVEIVLTHEHYDHTTGVKWLQSKIETRLFCHRACAEAI
                     ATEKGNDPKTLGYILTLRDAVDGGHRRENFLATAKRYMLRADEAFDGDCGLKVGELVLR
                     CHPAPGHSPGSALYFLGETAFFSGDSLIQHTPTIVHLPGSDRRAYKQETKPYLRSLDKD
                     MMVFPGHGEPFKLGEAEFL"
     CDS             17076..17498
                     /locus_tag="ctg37_44"
                     /transl_table=11
                     /translation="MALDLYIFYFYFRDLNLKLFQVMNMSEFYSDFLYRYQTEAAPLNV
                     SIDSFCLREGVEYRNFIRWYRDNKKRLRESEMADIRISAIKVTGAPALTAPVNPPIAFC
                     TVSEFHLKLSNGIEIHKPDSHLEDITNLLSSLSRVC"
     CDS             17492..17824
                     /locus_tag="ctg37_45"
                     /transl_table=11
                     /translation="MLGLSSHMNFYLCEGFVDMRKGIATLSELVRRKLHKDPESGDVFI
                     FLGKDRRNIKILRHEYNGYVLYWQKLNRERFLLPVFNSDLNQYEISWDKLVVLLQGTVR
                     KGILVG"
     CDS             complement(17760..17903)
                     /locus_tag="ctg37_46"
                     /transl_table=11
                     /translation="MQIKNCAVYLTTNILINTQKSVFCIHFNQPKSLYEQCLEEALQAY
                     PN"
     CDS             complement(18620..19234)
                     /locus_tag="ctg37_47"
                     /transl_table=11
                     /translation="MFAAKIEVAINSHFLTAYVPFYVHLLIKSVFCNQILSSKVRRSGS
                     LLRQSVHPYSSIYKFSPHMRHTSITGNSLSMPVKKFINIVTIRGNITKKIFEMVLGNCH
                     TAATPVIQVISNLQGRILAAPDILLLVFHLSRFLVFDSDQFSSPITEQKLSLLKRRFRN
                     GVSCLPNRSVCFCIQLSTVEEENFAPASEKRATPRSEERLY"
     CDS             19683..19940
                     /locus_tag="ctg37_48"
                     /transl_table=11
                     /translation="MSVIRERLHREPNDGDVFIVMSRNRRIVRMFSFDNRSYSLFEKKF
                     VAGYLFMKVERNGADTVYRIDWKDVVLILENPIVKTLKIR"
     CDS             20013..21806
                     /locus_tag="ctg37_49"
                     /transl_table=11
                     /translation="MIDLQDIITTKRELLSRATCSLSPINYSAGMAEDQKERYIQYLAE
                     QNQDLRLTSDAMKLVLEDFMAQMKDLKDQVSSMESKHADLENRLSEEHKLRKSAERKIK
                     SLQERLDYAHQERFGDRRQKIKSKAKTGDSDRNKEKDDYDGTDDTLRTDSVGHVQSPEV
                     KEPSGKGRDLSNRPDGYKTTGVSGEVIEHPSDLTKVPGRIIERRMVRVFSFRTFLTEEC
                     FEMVHYAEPGKKPRWGYFPSEGHPEVVTRFEGTKATPEFLQAIAYEVYVKNVTFGLLHQ
                     WLTDMGMTISKNTLRNWLKKGKTYLDELVCVLKSIALEKDSIVNCDETWCKVRKYDHYK
                     KCYIWVLVNKAQKTAIFFYENGSRGRDVLTDFLGDAELKSIMSDGYNAYVFIGNDLKSA
                     RFKDTVHQVCMSHAKNKFVKASNQGGEPTAERFSEILKEFFMRERKYDDAGLTPKERFR
                     ERQSLETKELLIELRSQLDSELSKDSEFRSQYYREALNYLNRFWKEIFAYLDDGELPID
                     NNLAERTIRKLTTQRNNSLHYGSDAGAGMAATYHSVIGTVKLHGSSVWNFIGTFFKNIF
                     NGCRDYVNMVPDKITLATSQC"
     CDS             complement(22325..22549)
                     /locus_tag="ctg37_50"
                     /transl_table=11
                     /translation="MSMSQKQGLYRSALFLNTLLYRSNIPNIYQYMPIFPLNRQYIRIG
                     GENRIDNLRMFFVSTHCTASLVFTASSLL"
ORIGIN
        1 cttcggtttt agctattgac tccacaatgc agttggcaca acagacagga tatcatgttg
       61 ttagtttcgg ttacatgcaa aaaaacatag agaatcatat agatggtgga ccatgggagt
      121 ttctttctat gattgatggg gcggaatatg tgatgacgga ttcctttcat gccacagtgt
      181 tcgctttatt atttcataaa aatttttatg tgtttgatag gcaatatgtg cataaacaat
      241 ctcagtcatc aagaataaca gatttgttgg cattactaaa tttatccgat agatacaata
      301 caattcatat tgataataat aatataaatt attcgcttgt agatgacgtc ttatcgactt
      361 atagacaaga gtatgacaat ttttataaat atatttttgg aaatattgta tgaatacagc
      421 aattgttaaa agggcgttta gatacatttt tcggggaata ccacggccgc atataagtat
      481 tgcggtaaaa aattttacga cacgacgtct tgaaggaaga aaaattttaa taactggtgg
      541 tggcaaggga ataggttatt ggattgccaa aaaatgcgta tctgaaggag caaaagtgtt
      601 gatttgcgga aggcaagaag aaactctccg cagagcctgc cgggaattag gcgaatcttg
      661 tcaatatatt aagtttgatg tttctagtat tattgacata ccatcttttt taaatgaagc
      721 gttcttaaga atgaatggta tagatagcct tgtgagtaat gcgggtatat ctttacatga
      781 gggctctttt aaaaatgtaa cggagagtgg ttttgatgct cagttcaaag ttaattttaa
      841 ggcaccatat tttcttgcta aatatttcgt tgaaaaaatc gaaaatgaaa agatagactt
      901 tgctaatatt ctattcgtta catcagaacg tggaagcttt tgtacttcta taccatacgg
      961 ccttactaag gcatctttaa aaaactatgt tggggcattg tgtcgttatt attgttttaa
     1021 tgaacgtata cgagtaaatg caattgcccc aggagtaact tcgtctgaaa tgacaggata
     1081 tagtgaaaac ggagattttc aaactgatga cagcccaaac ggccgtatat ttcatccggc
     1141 agaaatggct aatgttgctt gcttcttact cagtgatgaa gcatcgtgta ttagtggaga
     1201 gactattcat tgtgattttg ggagacatca gagtgtaatc gattagtata ggaaaaacat
     1261 gaacatcaaa taggtttttt atgattgata gcattatttc gtgtttaaac gctaaaggtg
     1321 tagtaagatt tgttaataca actacacaga taaaagaaaa aatatcatac ccttccaata
     1381 tagaatggta ttatattgaa gatgttagaa gtgctgtttt taacgcatat ggaatgtcaa
     1441 agattagcca ttctccagtt gctattatag tggaggaggc ctacttacct aatacatata
     1501 ctgcactcac ggaagcatgg cttcaaagag tgcaagtgat tgtattggca ttgaatagta
     1561 tgaatttgga tagttcgttc tatttgaata ggtgcgttga tgcatctatc ctaatcgata
     1621 atgtggaaac aattgaaggt gtagtatgta atgctattca acatcatgga ccttctctta
     1681 taaaaataaa ggaggaggta aacgaagaaa aaaagattga ttataccaat ctattttcaa
     1741 ttatagattt gtgcgcgaag gataaaaaag ttttatgtta taatcctcaa tatggtaata
     1801 aagactatga atttatacca ccagagtata aatatggtgt tatttcaaaa tatgtaggac
     1861 aacttatagg aggaaagcaa tcggttttat gtattccaga atacttattg gcattggata
     1921 caaatatatt taatttcagg gattttcctg acggtttcaa attaattgta aaatactccg
     1981 acggtgtttg ttgggggcgt cttaatactt ggatgcagag gaataacatc aacacatatg
     2041 ttgtagacgg tcgttcgttt gaatatacga caatgaattt taagcccaat tatgcaatct
     2101 tagtaaaata gaggttatga agacaaagat aaaacaggta cagcagattg tatcattatt
     2161 aaaacaaaat aatatacgac attttgtcct ttcgccaggg acgagacatg tggcctttgt
     2221 acatattgtt gaaatggatc ccttttttag gtgttattct atcgtagacg agcgaagtgc
     2281 cgcatttttt gctcttggac tctctgaggc attagatgaa cccgttggtt ttgcttgtac
     2341 atcagctact gcatcatgca attatatgcc ggctatgaag gaggcttatg agagaaatat
     2401 tcagttggta gcattaactt cagacaagca aagatatcag agatttcatg gtgttagtca
     2461 agtaataaac caagttgata tgttcgcacc atattgtcga tatgctgtag atttgcccga
     2521 agtgaatgat tccatggatg aatggttctg caatcgttgt attaatgaag cattgttaga
     2581 aatggatcat catggaagag gccctattca aataaacttt ctagagccca gtagcattga
     2641 tgaactatcc atcttttacg atggtaatat gcctgtgtgt cgaaaaataa atagaattga
     2701 ggattggtca caaattaatg agtggaaaaa tgtacttgca gcaaaaaaaa gaattcttgt
     2761 tgtttgtggt cagtatcagg agtttacagg gtgtttaagg tcaagtataa gaaagtttta
     2821 tgagaaatat aattgtgcgg tatcatttga tgcgttttca aatgttgcag acaaagactt
     2881 tattcaaaca atgttgttgt caataacact taatcagaag gaactgctaa gtttgaaacc
     2941 agatcttatt attacatttg gaacaaaata tttctcagac attgtctcac gttttgcggg
     3001 aatgggaatt gaacactggg aaatcaattt tgaaggtcgt atttttgaca caagcaggtc
     3061 gcttactaaa atattcgagt ttactccaga ggaatttttt gacaaagttt cctataatat
     3121 cacgacaaac gataagcagt atgataaatt gtggagggct ttgaatgaaa gccgagataa
     3181 ttctatagat gaatttacta attattatgt tgcaaaaaag gttttggaat ctttgcccga
     3241 aggcagtaat gttcatgcaa gtgttctgaa tagtatgaaa ttcacaaata tgagtaagct
     3301 cccacaaaat actattgcaa caggtaacaa ttgtgcagat ggaatagatg gagctctctc
     3361 tacttttatt ggccaagccg aagtgcttga tagtctctcg ctgcttgtta taggggattt
     3421 gagctatttg tatgatctaa atgcagctat ccatgacttt aaaaataaca ctagagtttt
     3481 actcattaat aattttgcgg ggggcgaatt ccattttaat attgggaaga aaaaaatatc
     3541 cacacttgaa cagcatatag cggctggaca tcatacaaaa atacaagatg ctattagttt
     3601 atctaatttt caatacatag ctgttcataa taaaggcgaa ttagaagaaa aactttcact
     3661 ttttttgcgg gaaagtgaaa atccaatttt aatggaggtc tttaccaacc ctgaactcga
     3721 tggttcttcc ttgaaaaaac ttattcgaaa taatataaaa atgacaccag aaaggctgat
     3781 agctgggttc gttaacaagt tcctagattg taggactaaa tatgcgataa aaaaattctt
     3841 acatagataa aagtaatata atcttttagt attattcgat taatgcgtgt attaatatac
     3901 ggttttaccg gaaacgtttt aggggggatt gaggtatata ccctcaatat gagcgaatac
     3961 atgtctgatg attgtgtgtt tgattatatt gttgacgggg atgaatgtgc atatagagaa
     4021 cggataacga aaagaggtgg aaaaatattt tttgttcctt gggtaagaag acatcctctt
     4081 gggtatataa acaaattgtg gcgtattttt ggtgaagaga agaagtctgg cacaaatata
     4141 ttatatcatc aactatttac aatgtctaac ctcataccag atgttattgc aaaacttagg
     4201 ggatataagg taattttaca tgctcataat aatggactac agaaaggcgg aagaatgtat
     4261 ttgatggcac acaatttagg aaaaattctt tcgagattct gtggttttgt gatgttcaca
     4321 aattcccagt tgtcctcaga ttatatgttt gggaagggtg ttaattcgaa gcttatatat
     4381 aatgctattg atgttgggaa gttcgctttt aaacaagaac atagagattg tataagaaaa
     4441 gaattggact gtcagagcaa gacggtaata ggatttgttg gtagacttgt agaccagaag
     4501 aatcctttgt tcatgcttaa agtcttcgct gaaattcata aacttcgtcc gaatagtgag
     4561 ctttggataa ttggagaagg aattttgaga ggaaaaatgg aagtagaaat aaacgagcaa
     4621 gggatatgtt catcagtaaa atggcttgga cgaagagagg atgtcaatag attgatgcaa
     4681 ggaatggatc ttttgttaca gccgtcagta tttgaaggct taggaatagt acttgttgaa
     4741 gctcaagcaa caggccttgc cgttgtttcc tcagaagtcg ttataccaaa agaggcagta
     4801 atttctgata gaataaagct cttaccgctt agcgaaaaac ctgcatattg ggctgctgaa
     4861 agtgttaatc ttttagattc gtgctgtgaa tcttatgata gaaccaatgc aatagttcca
     4921 gattgttaca atatacagca tgaggcaaag agacttgaaa gcatgttaaa agaactgatt
     4981 agttaataag atgattatac ctgttaaaac cagtaagtgg ttcacttatt atctattatt
     5041 tctcccgtta gtaatgatgt acagtgtgcc tggtactgga atacggattc ctacgctttt
     5101 gacagcaatt gcaatgttgt attctctctt gcagttagcc aataggcata tgagagtgcc
     5161 aatttatatg ttattaccat tgttcatgta cttgacatat gtgatgttta agagttcttt
     5221 acaacttgca tttctttgcg gcagtgtgat aattattata tcggcaatct gtacaggtat
     5281 agtaaatgtt tttttattaa gaaaagtact ggaaaaggtc gcaattgtcg ctgcattctg
     5341 tgtaatcttc cagcaaatcg ttcatatcct gacaggcata catttccatt tttacctcct
     5401 tccttttttt gcaaatgatt tgttggaaca atacaacaat gcgattacta ccggagctgt
     5461 tgagggaatg tataggccat gtgcattttt cttagaacct gcacagtatt cacaatattg
     5521 tacaatcggt cttgggtctt gtttgtttac ccatagacca aagacgaaga atgctctttt
     5581 tatttctctt ggtatatttg caagtacttc aggaatggga tttgtttcag tgtttgctat
     5641 ttggggggcc tgggctcttt caaggcaaaa aactaagaaa aactttatca ggagtttacc
     5701 tgtaatcctt atcgcacttt ttttggtgtt ttttttatta gacaatatta gttttacaca
     5761 taatattata aaccgtttta cttcaacctc aggtgatgat tataatgcca ttaatgggag
     5821 gctgttttgg tgggatacat attttggtga ttttaatata tctgattttt taacaggttt
     5881 tggcttggat aatttacctg atggagtcta ttttacgggt tttatgaaac tattatactg
     5941 ttacggtttg ataggaacga cactattgct actattcctt ggcatgctaa taatcaaagc
     6001 ggacatcttt gtaaaggtgt gtacatctct atacacggga ttgctgtttt ttgctgattt
     6061 gacttattat cataatttaa tcttttacat aggagtatat cttgcattgt atatttttaa
     6121 taaggaaaga gtcaatattg caggaacatt gaaagcctga aatggatata aaaaaatgga
     6181 taaaaataat tcttttaatc ttcgtgcttg gttatggggt aagatgacat ctttataccc
     6241 caaatatctt aaatggcatt ttaagatgga tataggtgag aatgcagtaa tagcacggac
     6301 cgcagttctg gataaaaaca ttaaccccca aggtattcat attggtaaaa atacatgggt
     6361 gttgagagat gctattattc tggcacatga tcactgcaga ggcaaaaatg ggaaaggaag
     6421 gttatttgac actcggattg gaaagaattg tgtgattggt attcgcagta tcattctgcc
     6481 cggtgtaacc gttggagatc attgcgttgt agccgcaggt gctgttgtaa ccaaaaatgc
     6541 ccccccccaa ctccataata gccggcaatc ctgcggtagt tattaagacg ggcgttgtga
     6601 taagtgatgg agggcaaatt attgaatgcg gagaaaaaat ataaatatgt ataagcactt
     6661 ctttaaacgt ccatttgatt ttattatcag tttggtcgct ctgatttgtc ttagccccat
     6721 attgttggct gtgaccattt ggcttcattt tgccaacaaa ggggctggag cattctttat
     6781 tcaagccaga cccggtaagg atgctgagat attcaaggtg atcaagttta aaacaatgaa
     6841 ggatgagttt gacgaaaaag gcgaaccgtt acctgatgag gtcaggctta ccaaagtggg
     6901 aaaaatagta cgctcaacat cattagacga attgccacag ctgcttaatg tgttgaaagg
     6961 tgatatggca ttgataggcc ccagacctct gatgccggaa tatctggagc tttatacgcc
     7021 tgagcaaatg cgccgtcacg aggtaagacc aggcattacc ggatgggcac agatacacgg
     7081 gcgtaatgag ttgcctttta ccgagcgctt cgagtatgac gtgtattatg tggatcatct
     7141 gacctttggc ttagacctga aaatattctt tatgaccatt gttaaaattt tcaaaagaga
     7201 aggaatatcc cagaaaggtc aggctacagt agagacattt gatggaacaa actaatatgg
     7261 aataacataa tgaaacattt ggtaataata ggcggcggag gaatgggtaa ggatatttac
     7321 cattcagcca agcattccat tggttatgga acagagtatg acataaaagg attcatagat
     7381 gacaatctga attccttgga tggttgtgag gggtatccgc cagtcttaga tacaataaag
     7441 aactatcagc cttcagaaga tgatgtattt acctgctcta tcggtaatgt gaaaacaaag
     7501 agaacgctct gcgaaatgat aaaagacagg ggggggaagt tcattacctt gctacatgag
     7561 acagcccaat tgggagaaaa tgtgaaactt ggtgatgggt gtatcatcga tagtcacgcc
     7621 cacataggat cagatacgat tataggcgag aattgtttgg tgcagacgtt tgctggaatt
     7681 ggtcacgact gtagggttgg tgattattgc cgcattgatg tcagggcatt tcttgttgga
     7741 ggcgtacgaa tagaagaaaa tgtaactata cataccaatg ccatattgaa ccaccatgta
     7801 gtagtggaga aagatgcagt ggtagctgca ttaagctttg tggttagaaa ggtcaaagct
     7861 ggaactaccg ttttcggtaa tccagccaaa ctgttgaaat attaaataaa acaagtaata
     7921 ataattgaat tattgaaaat tatggaatta aacgaattta ttgagaattt tgcagagcag
     7981 tttgacgaca ccgatgccag cgagattaag gcagacaccg tttttaagga actggacgag
     8041 tggtcatcgc ttgtggctct gagcgtgata gctatggtgg acgaggaata tgatattacc
     8101 atcaagggtg atgaaatctg gaattccaat accgttgagg acttgttcaa cgctataaaa
     8161 gccaaagcat aaacaatatg tataatccat attctctaac agggaagacc attctggtga
     8221 ccggtgcttc gtccggcata ggccgtgcaa cggctatcga atgtgctaag cttggagcaa
     8281 aggttgtcat tacagcccgt aatgaggata ggctgaaaga aacgcttgat acgctggagg
     8341 gtgaaggaca tcagatgatt tgtttcgact tgtctgaaac ggagaaactg aatgactttg
     8401 ttgcaagcct tcctccagta caaggctttg tgagcaatgc tggaactaca ataatagctc
     8461 ctattaaatt tattaaggaa gatagtctcg aaggattgct acaagtaaat acggtttccc
     8521 ctattctact tttgcaaaga ctacttaaga aaagaatatt aggcaagggc tcttctgttg
     8581 tattcacaag cagcatggct gcacttggaa aaggcacacc cggtaatacg atgtacagtg
     8641 catctaaagg tgccattagt gctttcatcc agaatgctgc actggaattg agtgcccaga
     8701 gaatcagggt caatgcagtg tgtccgggca ctgttgacac tccccttatt catagtggtg
     8761 gcattactga tgaacagttg agtgaagatg caaaaaaata tcctctcggc tatggacagc
     8821 ctgaagacat tgcattggga atagcatacc tcctttcaga tgcagccaag tgggttacgg
     8881 gaacaaatgt aattattgac ggagggttat ccgtcagttg ttgaaacaag gattactatt
     8941 atggcaaaaa taaaaataaa caacgtaaga atcaagggca tcgcagcctg tgcaccatcg
     9001 aaggtggagg agaacagcga atatccttac tttgacgaga acgagttcga aaacattata
     9061 ccaagtatag gcgtggaacg ccgccatgta gctaaggaag gtcagacgtg tgctgacttt
     9121 gcccagcgag ccgctgagaa actgatggaa gagttgggat gggagaaaga aagcatagac
     9181 ctgctcatct ttggctcccc ttccaaagac tatatccagc cggacacggc ttgtgtgctg
     9241 caaggcaagc ttgacctgcc ggaatcgtgc atggcattcg acatgactct gggctgcaca
     9301 ggctggacat acggcatgac caatgcctgt tcactgatgc agacagggtg catcaagcgt
     9361 gtactgttac tcaatggtat acagggttct gcggagagct gctactacga caagaccggc
     9421 tacccgctgt tcagcgatgt ggccactgct actgctttag aatatgatcc aacagcggca
     9481 cccatctatt gtgaactggg caccataggt aaacagtttg atgccattct tgttcctgac
     9541 ggaggtcgca ggaatcccgt gacagaaggg agtctgaaac tggtggagta tgaaaagaat
     9601 gtgaagcgaa accgtctgca cacctttatg aagggaatgg atgtgttctc ctttgccctg
     9661 aagactgccc ccaagagcac caatgcagtg ctggagtttg caggtaagga aaaggacgag
     9721 attgactact tcttcttcca tcaggccaac ttctatatgg tgaagaaaat catcaaaaag
     9781 ctgaagatag acccggagaa ggcacccata gtgatgaaag acttcggaaa cacaggtgct
     9841 tgcagtatac cctttacgat ggtgataggt tgcgcagaga aactgcgcaa cggaaagcat
     9901 accaatgtgg gctgttcgtt tggcgtgggt ctttcatggg gaagcttgtg ctttgagaca
     9961 gaaaacttag tgatacccga actgcaaata tacgattaat atgagaagtc agttagcaga
    10021 tttgttttat aagaacgcag cagagatgcc tgataagcag gctatctggt gcgacggaaa
    10081 aacagccacc tatcaagaga tggcaaatcg ggtgagccgc tattcgaact accttgttgc
    10141 gaaaggtgtt cagtatggtg accatgtggc catccccatg aacaatagca tagagtcagt
    10201 tgcgctgttt ttcagtgcgg cagacctggg cgtatgtctg gttccgctga accctacact
    10261 ccctttggag tcaattaagg tggccatgaa gtcgggcgac atgaaacacc tgatagcccg
    10321 caagagtttc ctgaacgaat gcgagaagaa aggtggagtg gacgtgcctg gcatcaccgt
    10381 atgcctagac ggagagtttg aaggagcatt ccctttcagt gaggtggcaa cgatgcctac
    10441 tacacgtcct gcctgtgaga atatcaaggg cgatgagagt ttgatactga ccatgacctc
    10501 cggctctacg ggaacaccga agccaattga catttctcag cagaacaaaa tagaccgctc
    10561 gctggctcat atccgagtgt atggactggt gaaggaagac agaatactgg ctgctacacc
    10621 gctgtaccac tccttggcag agcgcctggt gattatgccg ttgcttttgg gtgcgacctc
    10681 tatcctgctg ccacgattca ctccggcctt gtggctgaag tgtgccgcag aacagaaacc
    10741 gacgtttacc attgcggttt ctgcccagtt ggcgcagata cttgaactgc tgaagcagga
    10801 gaataccgaa agtatagaca gcttccacac aatcgtttct tcatcagccc tgctggagga
    10861 gaaggtgaag ctggaactga tagaccgttt gcagtgcgag ttccacgaga tgtatggcac
    10921 ctcagagaca tctacggcta ctgatatttg cttccagaag gcccgtaaca agcaaaagag
    10981 tgttggcctg ccctttgatg aagcggaagt gaagatacta cgtgacgacg aggataccga
    11041 atgcgctgtg ggcgaagtgg gagagattgc cgtgaagtcg aagctgacct gtaagggcta
    11101 ctataagctg aaaaacatga tggatatggc taccaccgaa gggttcttcc gtactggtga
    11161 cttaggctat atggacgagg atggctatct ctactttgcc ggacgcaaga aggagttgat
    11221 tatcacagga gccatcaacg tatatccaaa tgatgtggat gccgtagtga accagttgac
    11281 cgctgtggaa gaatgcgcag ctttctccta tcctgacgaa aggcttggtg aagtagtggc
    11341 actggctgtg gtggtgaagg aagattgcga actgacagag cgcaccatcc aaacctattg
    11401 cgccaagaac ctggcagact tccagcagcc acacaagatt ttctttgtgg atatgctacc
    11461 gaagaacaca atgggtaagc tgcagcgcaa ccgcatacta gaccatataa gaaatgtagg
    11521 aatagacaaa taaaaagaaa ttacgactat gacagatatt aaagaattcg tgacagaata
    11581 tattcagcgc gaatacaccg tacctgaaga cgtcgatatt atgactctca actatattga
    11641 ggcaggctat attgactcta tggctttcat tcagtttatc tctaccatcg aagacgagta
    11701 tgatattgag tttgaggtgg aggacataga gaatcctaaa ctgaggatag taggcaagtt
    11761 gattgatttt atccaagcca agatagacga acagcattaa gaccgtcatg agaaatatag
    11821 aaggaataaa aatagtagat gccactatcc gtgacggggg actggtgaac gacttcttct
    11881 ttaccgatga gtttgtaaag aaggtctatg aaaccaatgt ggctgcaggt gttgactaca
    11941 tggagtttgg ctaccgtgca gacaagaaga tgtttgatcc cagtaagttc ggtaagtgga
    12001 aattttcctc ggacgaggac atcttcagca ttgtgggtga caacccgacg gggctgaaac
    12061 tgtgtgtcat ggcagacgtt ggacgctgtg acttcaagaa cgatatccac aagaagtcgg
    12121 atagtccgct gagccttatt cgtgtggcta cctatataga gaccttttcg gaagctatcg
    12181 agatgataga atttgccgcc aagcaaggct atgaggtgac ttgtaacctt atggccatct
    12241 caaaatgtac gatgatgcag ttgtcgaaag ccttggatgc actggcccag acaccagtga
    12301 tgggcgtgta tatagtggac agttacggag cgctctatcc caaggaagtc cgtaaactga
    12361 ccaggcactt ccaagaccat ttgtcaccct acggcaaatt gacaggcatc catgcccaca
    12421 acaaccagca gtgtgccttc gctaacacca tagaggcaca cgacctgaat gccaagatgc
    12481 tggatgccac ctattatggc atgggacgag gtgctggcaa ctgtcacctg gaggcattgc
    12541 ttggctattt taacggcaag aagtatcatg tggagcccgt gttggacttg gtgggaagtg
    12601 atatgttggt catgaaagac caggagccca cttggggcta caatacatcg tatctgattg
    12661 ccggactggc caatgcccat ccgagggatg ctattgccgc cacaaagaaa aaagatacta
    12721 attttgtgga gcagtataag ttccagatat acaagtaagc gtggaaacga tagtggtaaa
    12781 cacctcaagg aagtaggatg tcctgttggg gcagggagtc attgctgact tgccccggct
    12841 ggtagagcca ttctgtaaag gagggaaggt gggggtcatc acggatgata ccgtagatgc
    12901 cctgtatgct gcaaaggcgg tatgggcaat ggaacaatac ggatatgatg tatgtaaata
    12961 cgtcatccca tacggagaga gttccaagaa cataaatact ctgtcaggta ttttggagta
    13021 tttcgcttcc tgtcatttta cgagaaagga cattttcctc tccattggtg gtggtgtgat
    13081 aggggacatt acgggagtgc ccgctgcact gtatatgtga ggcatccatt ttattcaaat
    13141 gcctactacg ctactcttta tggttgatgc ctcaataagt ggcaagacag ctgttgatct
    13201 gcaggcaggg aagaacttga taggcgcttt ctggcaacct tcattagtgg tggcagacac
    13261 acaagtggta accaacctac cagcagacat ctttgcagaa ggcatggcag aggtcatcaa
    13321 gagcgacttg atagctaatg ccggtattgt ggagatgata cgacagaaca caatcaagga
    13381 gcgtatagac cagatggtgg ccagttgcat caagatgaaa cgcgacgtgg tggaacagga
    13441 tgagtacgag accaaaggac tccggaaagt gctgaacatg ggacataccg ttccccatgc
    13501 tattgagaaa ctctccaact atagtatttc acatggtgtt gctgttgcaa cgggactggt
    13561 atgagaggct aagatagctt gtcatctggg actgtgtgct tccgggcttg ttgatgagat
    13621 acgcgctgcg gtggatgcct accaactcta ctacgacgta ccctataccg tatagaatat
    13681 ggtggaagcc atgaaaaacg acaagaagaa tgacgacagc aggatagact tcgtattccc
    13741 tatcgagtac agtaaatggg aggaaagaag actagaacag aaagagttaa tgaatattat
    13801 caaaacacta aatatctgaa tatggagcaa gtaaccattg gaatggcggg tgccggacgc
    13861 gctacggaat tgcacattat ggcattgaag cgctttttag gtgtgcctgt caggttgaag
    13921 accatcgttg caagacgtaa ggaacagcta gaggaagccc agcgtcttta tggctttgag
    13981 cagatttcgt acagctttga cgatatgatc aacgaccctg agatagatgt catagacatc
    14041 tgtacgcctc cctacgctca cgaggagatg atagagaagg ctatgatggc aggcaagcac
    14101 gtgatatgcg aaaagccgct gacgggctat ttcggaactc ccggcgatga agagcctatc
    14161 ggtgacaagg tgccgaaacg cgtgatgtat ctgaagatgt tggagcagat acgctacctg
    14221 cgcactgtta tcaagaaaac cggcaagaag ttcatgtatg cagagaactt cgtgtatgcc
    14281 cctgccgtga gaaagaccgc agagattatc aaggccaaga agagccgtat cctgttcatg
    14341 aaaggagagg agagcctgaa gggatccagt tcgcccgtgg ccggagaatg gagcaagacc
    14401 ggcggtggca ccatgattcg taccggtgca catcctcttt cggccatcct ctggctgaaa
    14461 cagcaggaag cccaagcccg tggagtagag attaaagtaa agagcgtgct gggcgtgatg
    14521 gatcggatca caccccaatt gaatgaatac gagcaccggc atattgccgc cagaccgcat
    14581 gacgtagaag atttcgggac tatcatactg gactttaccg acggcaccaa ggccgtggtg
    14641 atagctaccg acaccctgct tggcggttcg aagaactatg tggaactgta ttgtaacgat
    14701 gctgccatca actgcaacct caccatgtcc aacctgatga gcacttactt cctggatgag
    14761 gacaacttgg atgatgtcta tatttcagag atgcttcctt ccaagacagg atggaacaac
    14821 cccttcctgg aggatgagat aatacgaggc tatactgacg agatgcgtga ttttatggag
    14881 tgcgtgtatt atgaccgtga gcctcagtcg ggtttcactt tggcatatga taccataaag
    14941 attatttatg cagcctatat gtcagcagaa cttggcaaca aagtggaact aaacgcattc
    15001 tgattatgga tttcctgaag aaacttccta caccggaaga attggctaag atatacccgt
    15061 tgagtaaggg aatggccaaa aagaagttgg agcacgataa agagataaaa aagatattct
    15121 ccggggagtc aaaaagactg ctattgaata tcggtccttg ctctgcagac aggatggatg
    15181 ccgtactgga gtacgctgca cgccttgcag agatacagaa agaggtggtc gagaatattc
    15241 ttattgtgcc tcgtgtctat accagcaagc ccagaaccat tggtaaaggg tatatgggta
    15301 tgattcacca accctatatc gggcagggtg aagacctgtc gatgggtgtg gcggctgtgc
    15361 ggaacgtaca ccggcaagta gtggaagaga ctggattgtt cccatcggat gagctcttgt
    15421 accctgaaac tattcactat ctggcagacc tgttgggcta tgctgttatt ggagcacgtt
    15481 cggtagagaa ccagcagcat aggctggtgg ccagtggact aaatattcct gttggcctaa
    15541 agaatcccat aagtggcagt atcaacgtaa tgctgaatgc cattgagacc gcccagcatc
    15601 cgcaccattt tattttcaat ggatgggaag tgatgtcaaa gggcaatgag tatgcacacg
    15661 gcgtacttcg aggttatctg gaagaaggcg gtgccgcaac cagaaactgc gactatgagc
    15721 acctgtcgga gatttgtgac cgtttcgcag taaggaatgt tgaaaatcct gcggtggtgg
    15781 tggactgcaa ccacagcaat tccgacaagc agtatatgcg tcagatagac aacgcaatgg
    15841 aggtgctggg cctgatgaag gaatacccca agattaaaaa attggtgaag gggctgatga
    15901 tagagagcta tctggaagat ggcaaccagc ccattgatgg aggagtgtat ggaaagtctg
    15961 tgactgaccc atgccttggt tgggagaagt ccaaacaact aatatatgac attaacgaaa
    16021 aattagaggg actgaaatga gcgagcgacc gaagaagata ttctgttttg acaactaccc
    16081 ggaggcgaaa atggtattgg gaaaagtgac gtaccctgtc atcatcaagc catacgagtg
    16141 tgaagacaag acgttctggt ttgaagcgtc ggactatggt aaagccggtc aggtgctgta
    16201 tgatgccttt gaacacaccc gaaatggatg ggtgatgata gaggaacact gagtatgaac
    16261 tcttataagg cttttataga ggaacgcgag gtgtcaatct atcggttccc ctatgagttg
    16321 gtggattcca atatgttctt tattccatca ggggacactg ggattgtatt tgacccaaat
    16381 gagaatgaag agttgctccg agtatttcag gaactgggga caaggagcgt ggaaatagtc
    16441 cttacgcatg agcattatga ccatacgacg ggggtaaagt ggttacagtc gaagatagag
    16501 acgagactgt tttgccatcg cgcctgtgca gaagctattg ccactgagaa agggaatgac
    16561 cctaagacac tggggtatat actgacgcta cgtgatgcgg ttgacggtgg acacagaaga
    16621 gagaactttc tggctaccgc taagcggtat atgcttcgtg cagacgaggc atttgacggt
    16681 gattgtgggt tgaaagtagg tgaactggtt ttgagatgtc atccggcacc tgggcacagc
    16741 ccggggagtg ccttgtattt cttgggtgag acagcgtttt tttcaggcga ttcccttata
    16801 cagcatacac cgaccatagt gcatctgcca gggagtgaca gaagagccta taagcaggaa
    16861 accaagccat atttgcggtc acttgacaaa gatatgatgg ttttccctgg gcacggggag
    16921 ccgtttaagt tgggggaagc agaattcctt taaatattgg tgctatgagt aagaagatga
    16981 agattacatt gcttgctgcc atggtggcag ttggtgcttt gtacataatt tgtttgcaat
    17041 tgatttaaaa actaagatat gtaagcactc actgtatggc tcttgatttg tatatcttct
    17101 atttttactt tcgtgactta aacttaaaat tattccaagt catgaacatg tctgaattct
    17161 acagcgattt tttatatcgc tatcaaaccg aggcagcgcc tttgaacgta tctattgata
    17221 gcttctgctt gcgcgaaggt gttgagtacc gcaattttat ccgttggtat cgtgataaca
    17281 agaaacgttt acgcgaaagt gaaatggctg atattcgtat tagtgctatc aaagtgaccg
    17341 gagctccggc attgactgct ccagtaaatc cccccattgc tttttgcact gttagcgagt
    17401 ttcatttgaa actttccaat ggcattgaga ttcataaacc agattcccac ctggaagata
    17461 ttactaacct tttaagtagt ttgtcacgcg tatgttaggt ttgagctctc acatgaattt
    17521 ctacctttgt gaaggttttg ttgatatgcg taaaggtatc gccacccttt cggagttggt
    17581 acgccgtaaa ttgcataagg atcctgagtc gggtgatgta tttattttcc ttggaaaaga
    17641 ccgtcgtaat ataaagattc tgcgccatga gtataatgga tatgtgcttt actggcagaa
    17701 actgaaccgt gaacgcttcc ttcttcctgt tttcaattcc gatttaaacc aatacgaaat
    17761 cagttgggat aagcttgtag tgcttcttca aggcactgtt cgtaaaggga ttttggttgg
    17821 ttaaaatgaa tacaaaaaac gctcttttga gtgttgatta atatgttggt tgtcagataa
    17881 acagcgcagt tttttatttg cataatttat taaaaatgag tatattcact tcatgcaaga
    17941 caaagatatt atcaacatat taatctctca attactttcc aaggatgatg agttacgcca
    18001 tcaacgttcc cgtctggaga ctccgtttgg ctaactctga acaggaaaag tctgatctga
    18061 gggaagcctt gaaagctttg cagcaaactc gtgcggatga cctgtttgaa cttgaaagac
    18121 aaaaacggca actttacggt aggagttcag gaaaggttaa aagcctgaag aagctacagg
    18181 aaagaagcgt gaaagaagat aaggatgatt ttgatggttt caatccccct gggcttcctc
    18241 ctcatgaggg acatgccctc cttgatacta tgagatcatc tgatgctctt gtgggccagg
    18301 cagcaaagtc caaaccccac cgttcggatt atggcaagaa tgccactcag atagaatcta
    18361 ccgtgatgca ctactgtaac cgtgatcaag tccctgctga tgcccgccca atcgatgttc
    18421 gtcattggat actgtataaa atggattgga atgtgtgtaa gcatgttttc gaaattccca
    18481 gactgattga ctccgaaggc gctatcagta actattatgc ctcgtttgaa ggtgatgaag
    18541 ccttgcaccc ctttgagaat gttcttccgg gacatcatgt aggtatggat atgatagcac
    18601 agatcatggt agataaatat cagtatagcc tctcttcgga gcggggtgta gctcgttttt
    18661 cagatgccgg tgcaaagttt tcctcttcca ctgtactgag ttggatacaa aaacacacag
    18721 atctgttggg caaacaggaa accccgttgc ggaatcttct tttgagcaaa gacagttttt
    18781 gttctgtgat gggactactg aactggtcag aatcaaaaac aaggaaacgg gaaagatgga
    18841 atacaagaag cagtatatct ggggcagcaa gaatccggcc ttgaaggttg cttattacct
    18901 gtatgactgg ggtagccgca gtatggcagt tgccgagaac catttcaaag atttttttgg
    18961 taatattacc acggatggtt acaatgttta taaacttttt gaccggcatc gaaagggagt
    19021 tacccgttat ggatgtatgg cgcatgtgcg gcgaaaattt gtagatgctt gaatacggat
    19081 gaacgctctg tcgaagtagt gaacctgatc tccgaacttt actggataga atctgattgc
    19141 aaaatacact ttttatcaga agatgaacgt agaaaggaac gtaagcagtc aaaaaatggc
    19201 tattgattgc aacctctatc ttcgctgcga acaaaaattt tagaatttat gtatagcagt
    19261 gaagatcttg aaaggtttta ctttcaatac cagaccgagg ctttgcctca tggagaatct
    19321 ctccaatcgt tttgcgttaa gaacaaagtt ccttataaca tctttcagaa atggtacaag
    19381 gatacccgta aaaaagtagt tgaagtccag gttgatggtg ctcctgcaat tggtcatgag
    19441 gaaaaatcca gggctagtga tcaacctcaa ccggtatcac caagcagaga tgatcacccg
    19501 gttcgtattt gggttgggat tcgtatcagc aatggcttgc atttgtccca aaagaattta
    19561 agctaccagg atttggttcg tatggtagag aagttggagg ggttatgttg agtgttaccg
    19621 gtctgaatca tttttattat gtccgtgatt ttaccgatat gcgttgtaaa cacagccgtg
    19681 tgttgtctgt cattcgtgaa cggcttcacc gtgagcccaa tgatggagac gtctttatag
    19741 tcatgtctcg aaatcgcagg atagtccgta tgttttcatt tgataatcgt tcatatagtc
    19801 tgttcgaaaa gaagtttgta gcaggctatc tgttcatgaa agtagagcgg aacggggcag
    19861 atactgttta tcggattgac tggaaggacg tggttttgat tcttgagaat cctatagtta
    19921 aaacattaaa aatcagataa tcaatctatt tgtccacttg cgtttttgcg attattttat
    19981 tacctttaat gctgtaaatc aaaggtttaa gtatgatcga tctgcaagat ataattacaa
    20041 caaaacgaga gttgttgagt agggcaacct gctcactcag ccctataaat tatagtgcag
    20101 gtatggcaga ggatcagaaa gagcggtaca tacaatacct tgccgaacag aatcaggatc
    20161 ttcggttgac aagtgatgcc atgaagcttg ttttggagga ttttatggct cagatgaagg
    20221 atctgaagga tcaggtgtcc tctatggaat cgaaacatgc tgaccttgag aatcggttgt
    20281 cagaagagca taaacttcgc aaatcggctg aacgtaagat taaatcactt caggaaagac
    20341 ttgattatgc ccatcaggaa cgttttggtg atcgacgtca aaagatcaaa tctaaagcta
    20401 agacgggtga ttcagaccgg aacaaggaga aggatgatta tgatggaacc gatgatacgc
    20461 ttcgcacgga ttcggttggt catgtccaat caccggaggt taaagagcct tccgggaaag
    20521 gccgtgattt gtccaatcgt cctgacggtt ataaaacgac gggagtatcc ggagaagtaa
    20581 tagagcatcc ttctgacttg acaaaggttc ccggtcgcat cattgaaagg agaatggtac
    20641 gggtgttcag tttccgtact ttccttacgg aagaatgttt tgagatggtt cattatgcag
    20701 agcctggtaa aaagccgagg tggggttatt tcccttctga aggccatccg gaggtggtga
    20761 ccagattcga gggtactaaa gctactcctg aatttctgca ggctattgcc tatgaagttt
    20821 atgtaaagaa tgtgactttt ggtcttcttc accaatggct gacagatatg ggcatgacca
    20881 tttctaaaaa cacgttgcgc aactggctta agaaaggtaa gacatacctg gacgaactgg
    20941 tttgtgtatt gaagtctata gctttggaaa aagattcgat tgtgaactgc gatgagacct
    21001 ggtgtaaagt gcgcaaatac gatcactata agaagtgcta catttgggtt ctggtcaaca
    21061 aggctcagaa aacagccatt ttcttctatg agaatggctc gcgcggtcgt gatgtactta
    21121 cagacttttt gggcgatgca gagttgaaga gtatcatgtc cgacggatac aatgcttatg
    21181 tgtttatcgg caatgatctg aaatcagccc gttttaaaga tactgtacac caagtttgta
    21241 tgtctcatgc caaaaacaag tttgtcaagg cttccaatca gggtggtgaa ccgactgcag
    21301 aacgcttttc cgaaatttta aaggagttct ttatgaggga gcgtaaatac gatgatgccg
    21361 gattaactcc aaaagaaagg tttcgggaaa ggcaaagtct ggaaacgaag gaactcctga
    21421 tagaattgcg cagtcagttg gacagtgaac tgtcaaagga ttcagaattt agaagtcagt
    21481 attataggga agctctcaat tatctgaacc ggttctggaa agagattttt gcctacttgg
    21541 atgatggtga attacctata gacaacaatc tggcagagcg aaccattcga aagctgacta
    21601 cccaacgtaa taattcactt cattatggta gtgatgccgg tgctgggatg gctgcaacat
    21661 atcatagtgt gattggaacg gtaaagcttc atggcagttc tgtctggaac ttcatcggaa
    21721 cttttttcaa aaatatcttt aacggatgca gggattatgt taacatggtt cctgacaaaa
    21781 tcactttggc taccagccaa tgttaaattc aagactaatt aattaacaaa actcggttta
    21841 gggcactgaa aagtgccctt tcaaaggggg atgccctaaa ttgagtgctt acgaaaggaa
    21901 cggcaacaaa gagcattacc tgttcttgat aaactttggc aaataataaa gccaattttt
    21961 gatgcgaccc aagatgctgc atccaatctc tttatcaagg cgatccggta tgctgttgcc
    22021 gaatgggagt caatatgctg ctatgtgaat aatggtaaag cagagattga caacaataca
    22081 gctgaacgga tgatgaagcc tatttgcttg ggtcgtaaca attatttgtt ttgcggggca
    22141 gaaccgggtg caaagaatac ttctttatta tactcaatta ttgagacttg caaaatgaat
    22201 gggctaaggc ctgttaaata cattgcggat gttttaagga agttggtggc cggcgcaacg
    22261 aattacgccg cacttttacc tatcaatata gcgaaataaa cataattttt aatcaaaaaa
    22321 taactcaaag taggctagag gcggtgaaaa ccaggctagc cgtacagtga gtgcttacga
    22381 aaaacatcct cagattgtca attctgtttt cacctccaat acgtatatac tgtctgttga
    22441 ggggaaagat gggcatgtat tgatagatat tggggatatt gctcctataa agcagtgtgt
    22501 tcaggaaaag tgcggaacgg tacaagcctt gtttctgact catactcatt acgaccatat
    22561 ttatggtata aaagatttat tacgattgta tcctgattgc acagtttaca cttcctcttt
    22621 cggtaaggag gctttaggtt cggataaact taatttttcc cgttatcaca atgatcctgt
    22681 aatatggatg ggagataatg tgacggtttt acatgagaat gataaagtgg aaatatttcc
    22741 gggaattttc gtggaagt
//
