LOCUS       c00052_gnlPro..        16056 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|FIAIMDAH_52.
ACCESSION   c00052_gnlPro..
VERSION     c00052_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 01:03:00
            Original ID  :: gnl|Prokka|FIAIMDAH_52
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16056
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16056
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[3100:6056]"
                     /cutoff="2000"
                     /detection_rule="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /neighbourhood="10000"
                     /product="Pyruvate2acetate-formate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      3101..6056
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="2000"
                     /detection_rule="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /neighbourhood="10000"
                     /product="Pyruvate2acetate-formate"
                     /protocluster_number="1"
     cand_cluster    1..16056
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /kind="single"
                     /product="Pyruvate2acetate-formate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16056
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Pyruvate2acetate-formate"
                     /region_number="1"
                     /rules="((PFL_acetate1 or PFL_acetate2) and Radical_SAM)"
                     /tool="gutsmash"
     CDS             2..136
                     /locus_tag="ctg52_1"
                     /transl_table=11
                     /translation="NYKPMNKEEIEEKKIREKEFKKELKKKAKEKRKEQTNNLFDEIK"
     CDS             149..1651
                     /locus_tag="ctg52_2"
                     /transl_table=11
                     /translation="MTMNNLHEYIGLIIAIIVVLIVIAAQIYSFLKTKKKISELEGLFE
                     DVDNLSLKETSITSGILQNKSSLQKFLQNIPSRYSDEDDSGDEYTDLSLIVPQNKNIYG
                     KLGLIIYRTNEYLCKNTGTSADLGILEDICDSQKGALEDEIHNSLNVPLYLGLAGTFVG
                     IITGLIGVDFNQIFGETDNLSGLQHLLYGIIAAMCASLLGLGFTVYNSAISYKSAVAKS
                     NEGKEEYMNFLRRELMPLLSNSMASSLNSLKGVLGHFVDKFGRNLDAYANSAELLNDNL
                     EKQHLVLAEINKLSLTQTANKIAATFMQLKDSADSLNVFKSYQEQLNSTIANVSGIVNQ
                     TQTIIDKFKDFSTGLSVVVSNQNKTTELQREFQEAITTHFPTGAEARDIWRKEFDLFIS
                     EGKQVSESLSTQLTASTEHIQNFVANNKEFFDTFDKLKEVLDTMVQYTQVQAECYKDMK
                     GEILNLRTDYHNAQLDSIELNKSILKAIETMTKSIKDLKEEK"
     CDS             1654..2298
                     /locus_tag="ctg52_3"
                     /transl_table=11
                     /translation="MPRNRSNTFWLSYSDLMTSLFFIMLVLFIVCVVKMKGINDQLDKE
                     VNAKEEQLRKIEELNNSIKEIDNKYFAYDEQFKRHTLKDIEVSFNTYSSNIYDIEQEQL
                     DKLLKAGLAIAHFMNSAKSKIPEAQYMLIIEGQSSKDYYTRNYELSYERALALIKFWSS
                     NGIEFDSLGNCEVLISGSGQSSKFRVQPDIRGNKDNQRFVMHIIPKPGIIE"
     CDS             3101..5329
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Pyruvate2acetate-formate: PFL_acetate1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Gly_radical"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg52_4"
                     /sec_met_domain="Gly_radical (E-value: 1.1e-46, bitscore:
                     148.2, seeds: 99, tool: rule-based-clusters)"
                     /sec_met_domain="PFL_acetate1 (E-value: 0.0, bitscore:
                     1170.4, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MELNKTFTNGLWNKEINVSDFVSKNIAPYTGDASFLQGPTERTKR
                     IWDICLKALEEERNNNGVRSLDNTTVSTITSHKAGYIDKDNELIVGLQTDELLKRSIKP
                     FGGINVVAKACRENGVEVDDKVKDIFTHYRKTHNDGVFDVYTEEIRSFRSLGFLTGLPD
                     NYARGRIIGDYRRLALYGIDRLIEAKQEDLRNLTGPMTEARIRLREEVAEQIKALKDIK
                     VMGEYYGLDLSHPATSAQEAVQWVYMAYLAAIKEQDGAAMSLGNVSSFLDIFIEYDLAH
                     GKIDETFAQELIDQFVIKLRMVRHLRMQSYNDIFAGDPTWVTEAIGGRFNDGRVKVTKT
                     SFRFLQTLYNLGPSPEPNLTVLWSPELPEGFKDFCAKVSVDTSSIQYENDNLMREVRNC
                     DDYGIACCVSYQAIGKQIQFFGARANLAKALLLAINGGRCENTGTVMVKGIPVLTGETL
                     KFEEVMANYKKVLTEIARVYNEAMNIIHYMHDKYYYEKAQMAFIDTDPRINLAYGVAGL
                     SIAIDSLSAIKYAKVTARRNEIGLTEGFDTEGSFPCFGNNDDRVDHLGVDLVYYFSEEL
                     KKLPVYKNARPTLSLLTITSNVMYGKKTGATPDGRAKGVAFAPGANPMHGRDKNGAIAS
                     LSSVAKLRYRDSQDGISNTFSIVPKSLGPTPEERVENLVTMMDGYFTKGAHHLNVNVLN
                     REMLEDAMEHPEKYPQLTIRVSGYAVNFVKLSREHQLEVISRSFHERM"
     CDS             5331..6056
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Pyruvate2acetate-formate: Radical_SAM"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1015:4Fe-4S single cluster domain (Score: 75.5;
                     E-value: 1.7e-23)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg52_5"
                     /sec_met_domain="Radical_SAM (E-value: 3e-31, bitscore:
                     99.5, seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINVHSYESMGTFDGPGLRLVVFLQGCPFRCLYCANPDTIDVKGG
                     TPTTPEEILQMAISQKAFFGKKGGITFSGGEPTLQAEALIPLFKELKANGIHICLDSNG
                     GIWNEKVEELFSLTDLVLLDIKQFNPERHRTLTGRSNEQTLRTAAWLEEHEHPFWLRYV
                     LVPGYSDSEEDTRLLGESLGKYQQIQRVEILPYHRLGVHKYEAMGWDYKLKEVKENTPE
                     QLERAEKLFKEYFTNVITN"
     CDS             complement(6125..8230)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fn3-like"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glyco_hydro_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glyco_hydro_3_C"
                     /gene_functions="other (smcogs) SMCOG1041:Fibronectin type
                     III-like domain (Score: 84.7; E-value: 1.2e-26)"
                     /gene_kind="other"
                     /locus_tag="ctg52_6"
                     /sec_met_domain="Fn3-like (E-value: 3.9e-27, bitscore:
                     84.7, seeds: 729, tool: rule-based-clusters)"
                     /sec_met_domain="Glyco_hydro_3 (E-value: 6.5e-75, bitscore:
                     242.7, seeds: 11, tool: rule-based-clusters)"
                     /sec_met_domain="Glyco_hydro_3_C (E-value: 1.4e-52,
                     bitscore: 169.0, seeds: 116, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKQMTLDEKIGQLAQCTYRGNFTGPDGGNIPKEEYVRQGRIGSML
                     NVIGVKDIRRYQELALQSRLRIPLIFGLDVIHGYRTGFPLPLAEAASFDLAMIEEAARY
                     NALESAADGLNWVFAPMVDISWDARWGRVMEGAGEDPYYGSRVAEARVRGLQGDDLADT
                     TTVMACMKHFAGYGAPIAGKEYNSVDMSMGHFANFYMPPYKAAIKVGAATVMSAFNDFN
                     NIPCTANDFLLNRLLREQWGFKGFVVSDYNSVEELVNHRYAVDKKDAAAKALNAGLDME
                     MVSTCYLTYLKELVQEGKVKESVLDDAVRRILEKKYELGLFEDPFRYCNPERAARILNA
                     PEVRNASLRMAERSVVLLENRESVLPLTAQTRKIALIGGLSKSQYDMAGAWAATTDRNK
                     VVTLYDALVRKGLEVSYAEGYDMKSNQLTGLQEALQAAEASDVIVVAVGERFGQSGEKA
                     SKVNIAIPEGQQKLVSELAKTGKPVIALVMCGRPVIFNEIREHADAVLCTWWLGSEAGN
                     AICNVLWGEYNPSAKLPMTFPAHVGQIPIYYQNKSTGRPTALKQTYKASYIDASTEPAY
                     PFGYGLSYTDFGYSDLKLLPGKAAGVHTEVSVKVTNTGKCAGEEVVQLYVQDKVASVTR
                     PIKELKGFRKIHLNVGESKTVAFQITDDALGFYDNEMNYMVEPGDFVFMVGGSSDDVQQ
                     ITYNLKE"
     CDS             complement(8360..10612)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fn3-like"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glyco_hydro_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glyco_hydro_3_C"
                     /gene_functions="other (smcogs) SMCOG1041:Fibronectin type
                     III-like domain (Score: 80.2; E-value: 3e-25)"
                     /gene_kind="other"
                     /locus_tag="ctg52_7"
                     /sec_met_domain="Fn3-like (E-value: 9.7e-26, bitscore:
                     80.2, seeds: 729, tool: rule-based-clusters)"
                     /sec_met_domain="Glyco_hydro_3 (E-value: 1.7e-54, bitscore:
                     175.7, seeds: 11, tool: rule-based-clusters)"
                     /sec_met_domain="Glyco_hydro_3_C (E-value: 5.9e-51,
                     bitscore: 163.7, seeds: 116, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MADGPQGIRNNTQSTLYPCGILSASTWNRKLARELGHGLARDAKA
                     RGVSILLGPGVNIYRSPLCGRNYEYFGEDPYLTGETAKEYILGVQEEGVMATVKHFAAN
                     NQEWSRHHASSDVDERTLQEIYFPAFRKAVQEAGVGAVMDSYNPLNGVHATENSWLNID
                     VLRKQWGFKGILMSDWTSVYSGVGAANGGLDLEMPVGKFMTREILIPAIENGIVKEETI
                     DAKVRHILQTLIAFGALDTPREDKSIDKDNAQSKEIALDLAREGVVLLKNDNGTLPYRN
                     GRTLVIGPNADIIPTGGGSGFVTPYSVVSLYDGMVQLKGGRQIELLSDSILYKDMSQQI
                     YTDGSFTQNGFKGEYYNTRNLTGELFQAAIEPAIDHAWKYGAPFDGMPVDQFSARWTGV
                     YKADKDGTVKFQLAGDDGYRLFVNDKLITGDWGNHSFSTRSAFMQVSAGEIYRLRIEYF
                     DNVGEATVSFQAGMMDEERLASSLKHARNVIVCAGFNSSTEGEGFDRPFALSYGQEYLI
                     NKVASLHDNVAVVVNAGGGIDFRNWGQSVQAILMAWYPGQEGGKALAEIITGKLSPSGK
                     LPVSIEEKWEDNPVYGNYYDNRNVPHKRVQYAEGVFVGYRGYDRNGKQPLYPFGYGLSY
                     SSFEYSNLSVEKTGGSRVTVSFDIKNTGKMDAAEAAQVYVRDVECSVPRPLKELKGYDK
                     VYLKKGETKRVRILLDEEAFAYYDVESHRFVVEKGTFEILAGPSSADLPLKATVVL"
     CDS             complement(10999..12327)
                     /locus_tag="ctg52_8"
                     /transl_table=11
                     /translation="MKERMEDELWLKKIKDKLEDYSEPLPVAGWERLEKELSLSGTPIT
                     GSHRMMPFRRWAVAAAAVLLVAVSSVSLWLLQSPVGNEMRHTSVPALAVAPDVLPEQTV
                     PAVRTNPIEPAYRAHGNASAPNREASRPLVAQHIRISVDDERQEEMLPVETAGEAVGIG
                     QQAEEPVMEDTDHATAMQAEEPERTRKDRYRPSGRDKLHLPERNSSGRDTKGWAVGLSV
                     GNTGGFSLANEGEANVMSDYMPGSPIYGGNVDLSSTANGIVTIPDGQELVFKDGMPYLQ
                     RREKKIADIDHKQPLSFGVSVRKNLAKGFSVESGLTYTYLASDVRYEGSSEKISQKLHY
                     IGIPVRANWNFVDAKNFTMYVSAGGAIEKCVYGKIGTESETVKPVQLSVMGAVGAQYNI
                     SNRVGLYVEPGVSYFFDDGSSIQTIRKENPCNFTLQAGIRLTY"
     CDS             complement(12328..12876)
                     /locus_tag="ctg52_9"
                     /transl_table=11
                     /translation="MEEQELAERCRQGDNLARKELYERYAGRMLSVCLRYAGDRETAQD
                     LMHDGFLKLFDSFDKFTWRGEGSLRAWMERVMVNTVLQYLRKNDVMNQSSALENAPEAY
                     EEPEGSSIDVIPQKVLMQFISELPAGYRTVFNLYIFEEKSHKEIARLLGINEKSSASQL
                     TRAKATLAAKVREWMKRND"
     CDS             13058..13762
                     /locus_tag="ctg52_10"
                     /transl_table=11
                     /translation="MKKLRMTLATSMLLFLTAIVLQSCLDDWDDKYDTLFAVGTVKVIE
                     GKDYYFSLDEGSKLYPSDTTYVHDYAVTDGQRAFIYFRELEEKLPGYEYNAQIKHIENI
                     LTKDIYSMPAEKADSIGDDNINATDLWITGEYLNIKYQFYHSNNEDKKHMLNLVINEAS
                     TGENDKPDYVNLEFRHNAYNDSQLTLGTGLASFKLDNIAEQLKEKKGLNIRVKSLYDGE
                     RFMTIDIKKENN"
     CDS             14129..14632
                     /locus_tag="ctg52_11"
                     /transl_table=11
                     /translation="MVHPARFVRIVYADIYRSSICPLQQLGKRCGKTDTAVITGNADRF
                     VPVINHSAVEPADLELQPAGSILQAVGHCIYFQIIPLHYRRNQDVIIDLASIIVLRLPA
                     SVIVTARPGSYGPTVVVLPEKRPHIIRHLAAVRLDGRLDGISLQHMVHIKECPEITRLF
                     IFIQ"
     CDS             14657..14947
                     /locus_tag="ctg52_12"
                     /transl_table=11
                     /translation="MVATTLMGHHHLGTYIPVFGVRSIALDGVELWKRLKAVLAEKAGF
                     LAVIIGNGCFTMPDTPIVTVPVSSTGHLSLECERRRRPIEGSGCILPDHPG"
ORIGIN
        1 taattataag cctatgaaca aggaggaaat agaagagaaa aaaatcagag aaaaagaatt
       61 taagaaagag ttaaagaaaa aagcgaaaga aaagagaaag gaacaaacca acaatttgtt
      121 cgacgaaatc aaataatcaa aaaatataat gacaatgaat aatttacatg aatatatcgg
      181 cttgattatt gctataatag ttgtcttgat tgttattgca gcccaaatct atagctttct
      241 taaaacaaag aaaaaaattt cagaattgga aggtctattt gaagatgttg ataatttgtc
      301 tctcaaagaa acatcgataa catctggtat cttgcaaaat aagtcctcat tacagaagtt
      361 cttgcagaac ataccttccc gttatagcga tgaagatgat agcggtgatg aatatacaga
      421 tttgtcgttg atagttcctc aaaacaaaaa tatctatggg aaattaggat tgattattta
      481 tcgcactaat gaatatttgt gcaaaaacac tggaacaagc gcagatttgg gaatacttga
      541 agatatttgt gatagtcaaa aaggagcatt agaagatgaa atacataata gccttaacgt
      601 tcctctttat ttaggtttag caggaacatt cgttggtata attacggggc tgataggggt
      661 tgatttcaat cagatttttg gcgaaactga taatttaagt ggattgcagc atcttttgta
      721 tggtattata gcagccatgt gcgcaagttt actgggattg ggctttactg tatataatag
      781 cgctatatca tataaatctg ctgtagccaa atccaatgag ggcaaagaag aatacatgaa
      841 ctttttaaga agagagttga tgccgttatt atcaaatagt atggcttcaa gtctaaattc
      901 attaaaaggt gtgcttggac attttgtgga caagttcgga cgtaatcttg atgcgtatgc
      961 taattcggca gaattattga atgacaatct tgaaaaacag catcttgtct tagccgaaat
     1021 aaataaactg agccttacgc aaacggctaa taaaatagct gcaacattta tgcagttaaa
     1081 agattctgcc gattctttaa atgttttcaa atcttatcaa gaacaactta attctaccat
     1141 agcaaatgta tcaggtattg ttaatcaaac tcaaacaatc attgataagt tcaaggactt
     1201 ttctacagga ttgtctgtgg tggtcagtaa tcaaaacaag acaacagaac ttcaacgcga
     1261 atttcaagaa gccataacga ctcattttcc aacaggagca gaagcaaggg atatttggag
     1321 aaaggaattt gacttgttta tatctgaagg gaagcaagta tctgaaagct tatctaccca
     1381 acttacggct tcaacagaac atatacaaaa ttttgtggct aataataaag agttctttga
     1441 tacatttgat aaattgaaag aagtgcttga tacaatggta caatatacgc aagttcaagc
     1501 ggaatgttat aaggatatga aaggcgaaat cttaaacctt agaacagatt atcataacgc
     1561 tcaacttgat agcatagaat tgaacaaatc tattcttaag gcaatagaaa caatgacaaa
     1621 atctattaag gacttaaaag aagaaaagta attatgccaa gaaacagaag taacactttc
     1681 tggttaagtt attctgacct catgacaagc ttatttttta ttatgcttgt tttatttata
     1741 gtgtgcgttg ttaaaatgaa aggcattaat gaccaattag ataaagaggt aaatgctaaa
     1801 gaagaacagc tcagaaaaat cgaagaacta aataactcta ttaaagagat agataataag
     1861 tatttcgcat acgatgagca atttaagagg catacattaa aagacattga agtatctttt
     1921 aatacctata gttctaatat ttatgatata gagcaagagc aacttgataa attactaaaa
     1981 gcaggtctgg caatcgccca ttttatgaat agtgccaaaa gcaaaattcc agaagctcaa
     2041 tatatgctta tcatagaagg acaatcatca aaagattatt atacaagaaa ttatgagctt
     2101 agctatgaaa gagcattagc tttaattaaa ttctggtcaa gtaatggtat tgagttcgat
     2161 tcacttggca attgtgaggt tctaatttca ggaagtggac aatcaagtaa atttagagtt
     2221 caacctgata ttagagggaa taaagataac caacgattcg ttatgcacat aatccctaaa
     2281 cccggcatca tagaataaat caaaaaaggt agtcaaatga tagtatacta aactccattt
     2341 gattaccttt atataactgc aataaagcta atcttaaata atgcaaaaac acccaatttt
     2401 acattcttgg gtgtaaaatt gggtgtttat ttcacaattt gctgattttc agcatttatt
     2461 gcggagagac agggattcga accccgggtg cctcgcagca caacggtttt caagaccgcc
     2521 gcaatcgacc actctgccac ctctccaaaa cttctttttc agaagtactt ttcttttaaa
     2581 gcggtgcaaa gatacaaatc attttttatt ctacaaactt ttctgcacaa aaacagagca
     2641 attataccaa aattcttgtt tatacccact acggaacgaa cataacggca tttaggctat
     2701 ttgttgaaat ttatcaaggg caagacagag ttttataact tactggctat cagtatattt
     2761 acaaagagcc acattcagta tacgattgaa ccctattcag tatacgactg aatggcattc
     2821 actatacgac tgaattaggt tcagaatacg actgttcctt aaacctacat catttgtaaa
     2881 taatgcagat tattattcgg ttcttgtttc aattcataaa ccacatataa agaaagtatt
     2941 aacatctcta ctcccccgga cattcactac ctaataatag ttattttatg ctgttcaaca
     3001 taaaaagaga agtatctctt ataaaattac ggaatttatt cagtattttt gcgcgctcta
     3061 aaggataaca ttatctaacc tactaacaaa aacaaatatt atggaattga acaaaacctt
     3121 taccaatggg ctttggaata aagaaatcaa tgtcagtgat ttcgtcagta aaaacatcgc
     3181 accctatacc ggggatgcat ctttcttgca gggacctacc gaacgtacca aacgtatctg
     3241 ggacatctgt ctgaaggctc tcgaagaaga aaggaacaac aatggcgtcc gttcactgga
     3301 caataccacc gtatctacca tcacttctca taaagccggg tatattgata aggacaatga
     3361 acttattgtc ggtttgcaga ctgatgaact gttgaaacga tccatcaaac ctttcggagg
     3421 catcaacgtg gtagcaaaag catgccgtga aaacggagtg gaagtggacg ataaagtaaa
     3481 agacatcttc acccattacc gcaaaacaca taacgacggc gtattcgatg tatataccga
     3541 agaaatccgt tccttccgct cactgggatt ccttaccgga ttgcccgaca actatgcccg
     3601 cggacgtatc atcggcgact accgccgatt ggctctctac ggcatcgacc gtctgattga
     3661 agccaagcag gaggacttgc gcaacctcac cggcccgatg accgaagcac gcatccgtct
     3721 acgcgaagaa gtggcagaac aaatcaaagc tttgaaggac atcaaggtta tgggcgaata
     3781 ttacggactc gacctcagcc atccggctac atcagctcaa gaggccgtgc aatgggtata
     3841 catggcatat cttgctgcca tcaaagagca ggacggagca gccatgtcac tgggtaacgt
     3901 atcttcgttc ctcgacattt tcatcgaata cgatttggct cacggcaaga ttgacgagac
     3961 gtttgcacag gaactgatag accagttcgt catcaaacta cgtatggtac gccatctgcg
     4021 catgcagtcg tacaatgata tctttgccgg cgacccgact tgggtgaccg aagccatcgg
     4081 cggacgcttc aacgacggac gcgtgaaggt caccaagact tctttccgct ttttgcagac
     4141 gctatacaac ctcggtcctt ctccggaacc gaacttgacc gtattgtgga gtcccgaact
     4201 gccggaaggc ttcaaggatt tctgcgccaa agtttctgta gataccagct ccatccagta
     4261 cgaaaacgac aacctgatgc gcgaagtgcg caactgcgac gattacggca ttgcctgctg
     4321 tgtatcctac caagccatcg gcaagcaaat ccagttcttc ggcgcacgtg ccaaccttgc
     4381 caaggccctg ctgcttgcca tcaacggtgg ccgttgcgaa aacaccggaa ctgtcatggt
     4441 gaaaggtatt cccgtattga ccggcgagac actgaagttt gaggaagtta tggccaacta
     4501 caagaaggta ctgactgaaa tagcccgtgt ctacaacgag gccatgaata tcatccacta
     4561 catgcatgat aagtattatt atgagaaagc ccagatggca ttcatcgata ccgacccacg
     4621 catcaatctg gcatacggtg ttgccggcct ttccatcgcc atagactcac tgtccgccat
     4681 caaatatgcc aaagtcactg cacgccgcaa cgaaatcggc ctgaccgaag gtttcgacac
     4741 cgaaggctca ttcccctgct tcggcaataa tgacgaccgt gtggaccacc tgggagtaga
     4801 cctcgtttac tatttcagcg aagaactgaa aaagctgcct gtctacaaga atgcccgtcc
     4861 caccctttcc ttgctgacta tcacctccaa cgtgatgtac ggcaagaaga ccggtgccac
     4921 tccggacgga cgcgccaaag gtgttgcctt tgctccgggt gccaacccaa tgcacggacg
     4981 tgacaagaac ggtgccatcg cttccttgag ctccgtagcc aaattgcgct accgcgactc
     5041 gcaggacggc atcagcaata cgttctccat tgttcccaaa tcactgggcc cgacaccgga
     5101 agaacgtgta gagaacctgg taaccatgat ggacggctac ttcaccaaag gtgcccacca
     5161 tttgaacgta aacgtactga accgcgaaat gctggaagat gccatggaac atcctgaaaa
     5221 gtatccgcaa ctcaccatcc gcgtttccgg ctatgccgtg aacttcgtga agttgagccg
     5281 cgagcatcag ttggaagtca tcagccgttc attccacgaa agaatgtaat atgataaatg
     5341 tacactccta cgaaagtatg ggaacattcg acgggccggg tctccggctc gtcgttttcc
     5401 tgcaaggatg tccgttccgt tgtctgtatt gtgccaatcc ggatacgatt gatgtaaaag
     5461 gaggcactcc caccactccg gaagagattc tgcaaatggc tatcagccaa aaggcattct
     5521 tcgggaagaa aggaggtatt actttctccg gcggtgagcc taccctgcaa gcagaagcgc
     5581 tgattcctct tttcaaggag ctgaaggcga acggcatcca tatctgtctg gacagtaacg
     5641 gaggcatctg gaatgaaaag gtggaagagc tctttagtct gactgacctc gtgctgctgg
     5701 acatcaagca attcaatccc gaacgccacc gtacgctgac gggacgaagc aacgaacaga
     5761 cactccgcac cgctgcctgg ctcgaagaac atgaacaccc cttctggctg cgctatgtac
     5821 tggtccccgg ttacagcgat tcggaagaag acacccgcct gctgggtgaa agtcttggca
     5881 aataccagca gatacaacgg gtggaaatac ttccttatca ccgtctgggt gttcacaaat
     5941 acgaagccat gggatgggat tacaaattga aagaagtgaa ggaaaatact ccggaacaac
     6001 tggaacgggc agaaaaactg ttcaaagagt atttcacgaa tgtgataacc aactaaaaca
     6061 gaaaagcaag gctgtccgga tatgattcca gacagccttg cttttcattt atagggtaag
     6121 aatcctattc tttcaagtta taggtaatct gctgtacatc atcactactg ccacccacca
     6181 taaagacgaa atcaccaggt tctaccatat aattcatctc attgtcatag aatcccagtg
     6241 catcgtcagt tatctgaaaa gctacagttt tgctttcacc cacattcaga tgaattttcc
     6301 tgaagccctt caattccttt atcggacgcg taacagaggc taccttatcc tgcacataca
     6361 attgaactac ttcctctcct gcacacttac cggtattagt cacttttacc gacacctccg
     6421 tatggacgcc tgcagccttg cccggcagca gtttcaaatc agaatatcca aaatccgtgt
     6481 acgaaagccc atatccgaaa ggataggcag gctcagtgga agcatcgata taagatgcct
     6541 tataggtctg tttcaatgcg gtagggcggc cggtgctctt attctgataa taaatgggaa
     6601 tctgtcctac gtgtgcagga aatgtcatgg gcaatttagc cgaaggatta tactctcccc
     6661 acaacacatt gcatatggca ttgccggcct cacttcccag ccaccaagta cacagtaccg
     6721 catcagcatg ttcccttatc tcattgaaga ttaccggacg cccacacatg acaagagcaa
     6781 tgacaggttt tccagtcttt gccagttccg acaccagctt ctgctgcccc tcgggtatgg
     6841 ctatattcac tttggaagcc ttctcgccac tctgaccgaa tctctcgcct accgccacaa
     6901 caatgacatc cgaagcctca gcagcctgta atgcttcctg caatccggtc aactgattgc
     6961 tcttcatatc atagccttca gcatagctca cctccagtcc tttccggacc aatgcatcat
     7021 ataaggtcac cactttgttc cggtccgtag tggcagccca agcacctgcc atatcgtact
     7081 gggattttga gagtcctcct atcaaggcta tcttcctcgt ctgtgccgtc aacggaagca
     7141 cagattccct attctccagc aatacaacgg aacgctcggc catacggagc gaagcattac
     7201 ggacttcggg cgcattgagt attctggccg ctctttccgg attacagtag cgaaaagggt
     7261 cctcaaacaa tcccaactca tatttcttct ccaatatacg ccgtactgca tcatcaagca
     7321 cactctcctt tactttccct tcttgaacaa gctccttcag ataagtcaag tagcaggtac
     7381 ttaccatctc catgtccaga ccagcattca gcgctttggc tgcggcatct ttcttgtcaa
     7441 cagcataacg gtggttcacc aattcctcta ccgaattata atcggacaca acaaatccct
     7501 taaatcccca ctgctctctc aatagccggt tgagcaagaa atcattggca gtacaaggaa
     7561 tattattaaa atcattgaaa gcactcatca cggtagctgc tcctaccttt atggccgcct
     7621 tatagggagg catataaaaa ttggcaaagt ggcccattga catatccaca ctattatact
     7681 cctttcctgc tatcggtgca ccatatccgg caaaatgttt catacatgcc atgacagtcg
     7741 tcgtgtctgc caaatcgtct ccttgcaagc ctctgacacg cgcctccgct acccgagaac
     7801 cataataagg gtcctcaccg gccccttcca tgacgcgtcc ccaacgtgcg tcccacgaaa
     7861 tatccaccat cggggcaaaa acccagttca aaccatcggc ggcactttcc aaagcattgt
     7921 agcgtgcagc ttcctcaatc atggccaaat cgaaacttgc agcctcggca agcggaagcg
     7981 gaaatccggt acgatagccg tggataacat ccagtccgaa aattaaagga atgcgcaaac
     8041 gcgattgcaa agcaagctct tgataacggc gtatatcctt tactcctatc acattcagca
     8101 tagagcctat tctgccttgc cggacatact cttctttagg aatatttcca ccgtcgggtc
     8161 cggtaaaatt ccctcggtag gtgcattgtg caagctggcc tatcttttca tccagcgtca
     8221 tctgcttcat caagcttgag atgaatttct ccttctccgt agtttgtgcc gaggtaaagg
     8281 tgttaccaag tccccacaga caaaccatca gtattattat ctttttcata ctgccattct
     8341 tgttttgata tttattttat cataaaacaa cagttgcctt caatggtaaa tcagctgaag
     8401 aaggacctgc cagaatctca aaagtcccct tttccactac aaaccgatgt gattccacat
     8461 catagtaggc aaaggcttcc tcatccagca atatccgaac gcgcttggtt tcacccttct
     8521 tcaagtaaac cttatcgtag cctttcaact ccttcaatgg acgcggaaca gaacattcca
     8581 catcccgcac atatacctga gccgcttccg cagcatccat ctttccggta ttcttgatgt
     8641 caaagcttac cgtaacccgg cttccccccg tcttctcaac actcagatta ctatattcaa
     8701 aactactgta tgacagtcca tacccgaaag gatagagcgg ctgctttccg ttccggtcat
     8761 atcccctata acctacgaaa acaccttcgg catactgcac ccgtttatga ggtacattgc
     8821 gattgtcata ataattacca tataccggat tatcttccca tttttcctcg atgctgactg
     8881 gtagtttgcc acttggcgaa agcttgcccg taatgatttc ggcaagggcc tttccaccct
     8941 cctgccccgg ataccatgcc atcaaaatag cttgtacact ctgcccccaa ttgcggaaat
     9001 ctattccacc tccggcattc accaccacag ccacattatc atgaagtgaa gccactttat
     9061 taatgagata ttcctgcccg tatgacaatg caaacggacg gtcgaaccct tcaccttctg
     9121 tactgctgtt gaacccggca catacaataa cattcctggc atgcttcagt gaagaggcca
     9181 aacgctcctc atccatcatt cctgcctgga aactgacagt cgcctcaccc acattatcaa
     9241 aatattcaat acgcaaccgg tatatctccc ctgcactgac ctgcataaat gcactgcggg
     9301 tactgaatga atggttcccc caatctccgg taatcagctt atcgtttaca aacagacggt
     9361 atccgtcatc gccagccagc tggaacttga cagttccatc cttgtcagcc ttgtaaactc
     9421 ccgtccaacg ggcagaaaac tgatctaccg gcatgccgtc gaacggtgca ccgtatttcc
     9481 aggcatggtc tatggcaggc tctatggcag cttgaaagag ttctccggta agattacgag
     9541 tattataata ttcgccctta aaaccgtttt gcgtaaaact gccatccgta taaatctgtt
     9601 gggacatatc cttataaaga atgctgtcag acagcagctc tatctgtctg ccgcccttca
     9661 actgaaccat accgtcatag agtgacacta ccgaataagg ggtgacaaat ccgcttcctc
     9721 ctcctgtggg aataatatcg gcattaggcc cgattaccaa tgttctaccg ttccggtaag
     9781 gcaacgtacc gttatcattt ttcaataaga ctactccttc tctcgccaag tcaagtgcaa
     9841 tttccttaga ctgtgcattg tctttatcga tagatttatc ttctctcgga gtatcaagtg
     9901 ctccaaaagc aatcaatgtc tggagtatat gccggacttt ggcgtcaatg gtctcttcct
     9961 tcacgatacc attctctatt gccggaataa gaatttccct ggtcatgaat ttaccgacgg
    10021 gcatttccaa atccaaccct ccattagcgg ctcccacacc ggaatataca gatgtccagt
    10081 cagacatcag gataccttta aatccccact gcttgcgtaa tacatcaatg ttcagccagc
    10141 tgttttcggt ggcatgtacc ccgttcagcg gattatagct atccataacc gcccctactc
    10201 ctgcttcctg cacagctttt cggaacgcgg gaaaataaat ttcctgcagc gtgcgttcat
    10261 ccacatctga gctggcatga tgtctgctcc actcctggtt attggccgca aaatgcttca
    10321 ccgtagccat aactccctct tcctgcactc ccaagatata ttctttagca gtttcgcccg
    10381 tcaaataagg gtcttcacca aaatactcat agtttcgccc gcatagagga gagcggtaga
    10441 tattgactcc aggccccaac agaatactta ccccacgggc ctttgcatcc cgggccaaac
    10501 catgtcccag ctctctagcc aacttacggt tccatgtcga agccgacaag atgccacaag
    10561 gatacaaggt actttgagta ttgttacgta tgccttgcgg accatcggcc atcctgattt
    10621 cgggtatgcc aagccggggt acagcccgga tataaaaaga tttgggaccg gaaatgtaat
    10681 cgattttttc ttccagcgtc atttgagaaa ccaactccct ggcacgctgc tccacctggg
    10741 gagtaataca cacttgtgct tttgccgtga ttgtacaaca aagcaatagc ccgcttaagg
    10801 ctactttctt tttaatcttc attttgtcta ttttactacg tgtttgttat attgccgggc
    10861 atgtcccgac ctactttctt tcttctcaat caataaaaaa ccgtgtccct tcatccacca
    10921 acgaagaaac acggccgaaa gttattaaga aaattctgaa tctacaagaa agtggacaaa
    10981 aacatgtctg tcctgctatc aataagtaag acgtataccg gcctgcaacg taaagttaca
    11041 cgggttctcc ttgcgtatag tctgtatcga cgaaccgtca tcaaagaaat aagatactcc
    11101 cggttccaca tacaggccca ccctattgct tatgttatac tgggcaccga cagcacccat
    11161 gacagaaagc tgtaccggtt tcacagtctc actctcagta ccaatcttgc catacacaca
    11221 tttttcaatg gcaccccccg ccgaaacgta catcgtaaag ttctttgcat ccacaaagtt
    11281 ccagttggcc cgtaccggaa tgccaatata atgcagcttc tggcttatct tttccgagct
    11341 gccctcatac cttacgtcag aagcaagata ggtatacgtc agcccgcttt ccacagagaa
    11401 acccttcgcc aagtttttcc gcaccgaaac accgaaactg agcggttgtt tatggtctat
    11461 atccgcaatt ttcttttcgc gtctttgcag atagggcata ccatccttaa aaaccagttc
    11521 ctgcccgtcg ggaatagtaa caatgccatt ggccgtagag gataaatcta cgttaccgcc
    11581 ataaatagga cttccaggca tgtagtccga catcacattc gcttcccctt cattcgccaa
    11641 tgaaaaacct cccgtatttc ctacggacaa gccaaccgcc catcctttag tatccctacc
    11701 agaactgttt ctttccggaa gatgcagttt gtcccggcct gacggacgat agcggtcttt
    11761 ccttgttctc tccggttcct ctgcctgcat tgcggtcgca tggtccgtat cttccattac
    11821 cggctcttcc gcctgctgcc caataccgac agcctcacct gcagtttcaa ccggcaacat
    11881 ttcctcctgc cgctcatcgt caaccgatat tctgatatgt tgtgcaacca aagggcgact
    11941 tgcctcccta ttgggtgccg atgcatttcc atgtgcccga taggcaggct ctatgggatt
    12001 agtccgtaca gcaggtaccg tctgttccgg caagacatcc ggagccacag ccaaagcagg
    12061 cactgacgta tgccgcattt cattccctac cggactctgc aacagccaca gactgacgga
    12121 cgatactgcc accagcagca cagctgccgc agccaccgcc cagcgacgga aaggcatcat
    12181 cctatgcgat ccggttatcg gagttccgga aagggacaat tccttttcca accgctccca
    12241 tccggcaacc ggcaacggtt cggaatagtc ttccagcttg tcctttatct ttttcaacca
    12301 caattcatct tccatacgtt ccttcattta atcatttctt ttcatccact cacgtacttt
    12361 tgccgctaaa gtcgctttag cacgcgtcaa ctgcgaggca gaggattttt cattaattcc
    12421 caatagtcga gcaatctcct tatgggattt ctcttcaaaa atatataagt tgaatacggt
    12481 acgatagccg gcaggcagtt cactgataaa ctgcatcagc accttttgag gaatgacatc
    12541 tatcgacgaa ccttccggtt cctcataagc ttcgggtgca ttctccaaag ccgatgactg
    12601 attcatcaca tcatttttcc gcaaatactg caataccgta ttcaccatta cgcgttccat
    12661 ccatgcccgc agagagccct ctccccgcca agtgaactta tcgaaagaat caaaaagttt
    12721 cagaaaaccg tcatgcatca ggtcttgggc agtctcccgg tcacctgcat aacggaggca
    12781 tacgctgagc atgcgtcccg catagcgctc atacagttct ttgcgggcaa ggttgtcccc
    12841 ttgcctacag cgttctgcca attcctgttc ttccattctc tcttttaaca cgtgtttacc
    12901 ttaaaaatgc aactggcgca aaaatactgc atcaggcaga gaagaaaatc atactttcat
    12961 ttctttaaca atatactacg cagtatttag cttttcaccg cattttttga atacaaaaat
    13021 aagatttaaa cagaaaaaga gctaaaacct accacttatg aagaaactga gaatgacatt
    13081 ggcaacatcc atgcttttat tcctgactgc cattgtattg caatcatgcc tggacgattg
    13141 ggatgacaaa tatgacactt tgttcgccgt aggtacggtg aaggtcatcg aaggaaaaga
    13201 ctactatttc tcactggacg aaggcagtaa actatatccc agtgacacaa cctatgttca
    13261 cgactatgcc gtaacagacg gccagagggc tttcatctac ttccgcgaac tggaagagaa
    13321 acttccaggc tacgaataca atgcccaaat aaagcacatc gaaaatattc tgaccaaaga
    13381 catctactcc atgcctgccg aaaaggcgga cagtatcgga gacgacaaca tcaacgccac
    13441 ggatttatgg attacgggtg agtatctgaa catcaagtat caattctacc acagtaacaa
    13501 cgaagataag aagcacatgc tgaacctggt catcaacgaa gcatccaccg gcgagaacga
    13561 caaaccggat tacgtcaatc tcgaattccg ccacaatgcc tacaatgaca gtcagctcac
    13621 actgggcacc ggactggcct ccttcaagct ggacaatata gcggaacagc tgaaagagaa
    13681 aaaaggactg aacatccgcg tcaaaagtct atatgacggt gaacggttca tgaccataga
    13741 cattaaaaaa gaaaacaact aaatctcctg aaaacacatt tttcaacatc tcaatgagaa
    13801 gcggagtaac atttcaatat gttgctccgc tttgtttttc cataacttat cagaattcat
    13861 tgttcaagca agtcagcctc aacgaagcgt tgaacgcttc ggcagacaat cgcgtcctga
    13921 cctgtacctg cacgctgctc ttcggctgga catcaaaata attgtcgcta tatacacttt
    13981 cattgtcagc aacggacaag catacggcac gggcaaactt gtctgttgat accgtcactt
    14041 catatccgcc ttcaatggaa cggacttcgg tctgcaaatc cactttcgga taattcatat
    14101 tcttctgctt gtccagacag tagttgttat ggtacaccct gcccgatttg tccgtatagt
    14161 ctacgcggac atataccgtt cctctatctg ccccctccag cagcttggca agcggtgcgg
    14221 aaaaacagac acggctgtca ttaccggaaa tgccgacaga tttgtcccag tgataaacca
    14281 cagtgccgtc gaaccggcag acctggagct gcagccggcc ggaagtattc tccaagcggt
    14341 cggacactgc atatactttc aaatcatccc cctccactac cggagaaatc aggatgtcat
    14401 catagacctt gcgagtataa tagtgctgcg ccttccagcg tccgtaatag tcacggctcg
    14461 cccaggaagc tacgggccaa cagtcgttgt gctgccagaa aagcgtcccc atattatacg
    14521 gcatctggcg gcggtgcgac tcgatggccg tcttgatggc atctccctgc agcacatggt
    14581 tcatataaag gaatgcccgg aaatcacgcg gctttttata ttcattcaat aggtaagtct
    14641 caatcagccc gttggcatgg tcgccaccac gctgatggga catcatcacc tcggaacgta
    14701 tatcccagtc ttcggggtaa ggagcatagc gcttgacgga gtcgaactct ggaaaagact
    14761 gaaagccgta ctcgctgaaa aagcgggatt tctcgctgtc ataatcggaa atgggtgctt
    14821 taccatgcca gacactccaa tagtgacggt ccccgtcagt agtaccggac atctctccct
    14881 cgaatgcgaa cggagaagaa ggccaataga aggttccggg tgcatactcc ctgaccaccc
    14941 cgggtaaggt gacatgatac tgctgccggt actgtgccca aatcttgtcg gcatattcct
    15001 tgttctgccg ttctatctcg cacttccagc cccagcccag ccaggcatcc tggcattcat
    15061 tgtttccaca ccacaaagca atgcaggcat gattgcgcaa acgtttcaca ttgtccaccg
    15121 cctcctgatg gatattatcg agcagggcgc cttctgccgg atacatgctg caggcaaaca
    15181 taaagtcctg ccaaatcata attccatgct catcacacaa atcatagaag acatcgttct
    15241 catagatacc tccgccccag acacgcaaca tattcatgtt tacaccggcg gcatcgagaa
    15301 tcgtcctttt ataattctcg ggagtgacgc gcggcaggaa gttatccgaa gggatgtaat
    15361 tggctccttt ggcaaaaacc ggacgcccgt tcagctctat atagaaagta tgcccgtcct
    15421 tatccggctg atgcaccacc ttcaaagagc gtatgcccac cctttcggtt ttagagtcca
    15481 acaattcccc gcctgcaatg atatccgtac ggaaacggta aaggaaaggc tcccccagtc
    15541 cattactcca ccacagcttc ggcttgtgaa ggacgaaatc aacggtcacc cgattggtgc
    15601 ctcgcttcaa atccgcttgc cactcgccaa gcactcttcc ggtagcctcg tctgttatcg
    15661 tgaccagcac tccgtccata tccttatcgg catccagctc cacatgtccg gcaatcacgg
    15721 ccctgcctgc accgacttcc ttctgctcga taaacacatc gttgattctc aaatcgctcc
    15781 aagccctgat atacaccgga cgccagatgc cggaggtaac cagacgtggg ccccagtccc
    15841 agccataatg ataacccgcc ttacgggcaa aaatgcttat cttcttgttg aacaagcctc
    15901 cgttttcaga ctggtcattg gatgccggat actggtaagg aagtgcatcc catttgggga
    15961 cgtctatctt taccggcgaa tggaagtaca ccttcagtat attattctcc tccctgatgt
    16021 actgcctaac ggggatagac cagcggcgaa acatat
//
