LOCUS       c00006_gnlPro..        16947 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|BKCJJFII_6.
ACCESSION   c00006_gnlPro..
VERSION     c00006_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 01:09:35
            Original ID  :: gnl|Prokka|BKCJJFII_6
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16947
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16947
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[3955:6947]"
                     /cutoff="2000"
                     /detection_rule="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /neighbourhood="10000"
                     /product="Pyruvate2acetate-formate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      3956..6947
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="2000"
                     /detection_rule="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /neighbourhood="10000"
                     /product="Pyruvate2acetate-formate"
                     /protocluster_number="1"
     cand_cluster    1..16947
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /kind="single"
                     /product="Pyruvate2acetate-formate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16947
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Pyruvate2acetate-formate"
                     /region_number="1"
                     /rules="((PFL_acetate1 or PFL_acetate2) and Radical_SAM)"
                     /tool="gutsmash"
     CDS             762..1979
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fe-ADH"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1035:Iron-containing alcohol dehydrogenase (Score:
                     335.1; E-value: 1.4e-102)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg6_1"
                     /sec_met_domain="Fe-ADH (E-value: 8.8e-103, bitscore:
                     335.1, seeds: 219, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MARFTLPRDLYHGKGALEALKSFTGKKAMICVGGGSMKRFGFLDR
                     AVEYLKEAGMEVELFEGIEPDPSVETVMRGAEAMLKFEPDWIIAMGGGSPIDAAKAMWI
                     KYEYPEITFEEMCKVFGIPPLRRKAHFCAISSTSGTATEVTAFSIITDYQKGIKYPIAD
                     FEITPDVAIVDPDLAETMPKKLVAHTGMDAMTHAVEAYVSTAHCDYTDPLAIFAIRMIQ
                     GDLVDSYNGDMSKRDSMHNAQCLAGMAFSNALLGIVHSMAHKTGAAFADYGAHIIHGAA
                     NAMYLPKVIAFNAKDPEAKKRYGVIADEMKLGGANDDEKVKLLIEYLRGMNDALNIPHC
                     IQHYGPDSYPTEQGFVPENVFLERLPEIAKNAIADACTGSNPRQPSQEEMEKLLKCCYY
                     DTEVDF"
     CDS             complement(2139..3536)
                     /locus_tag="ctg6_2"
                     /transl_table=11
                     /translation="MQIFNTLTRQKEEFVPQVPGEYRIYVCGPTVYNYIHIGNARPLIV
                     FDTLRRYLEYRGNKVIYVSNITDIDDKLIKKGQEEGTSMKEVAQRFEAEYLKDAAGLNC
                     EKPTVQPRATEHIPQILDIVKDLIDSGHAYVAKNGDVYFRVKSDPGYGKLSHLNLDDLE
                     SGNRELRSRMEDDLKEDPADFAVWKAAKPGEPAWESPYGMGRPGWHIECSAMSRTHLGK
                     TIDLHCGGQDLIFPHHENEIAQSECANGCEFARYWMHNGFINVDNQKMSKSLHNFFTVR
                     DVANLYGYEPIRYFMLTAGYRMPLNYTVDLIESCKNSLERLYTCRENLDFALSKTDFGT
                     DETLKEKAAEARTKFCTAMDDDLNTPDALAAVFDLVKEINTLSAASSKAALETAAAAFD
                     EITGVLGLLYNRKKDEVPAEVTELVEKRAAAKKAKDWATADAIRAQLTELGWAVKDTAQ
                     GPQLSKL"
     CDS             complement(3956..4708)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Pyruvate2acetate-formate: Radical_SAM"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1015:4Fe-4S single cluster domain (Score: 62.7;
                     E-value: 1.4e-19)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg6_3"
                     /sec_met_domain="Radical_SAM (E-value: 2.6e-29, bitscore:
                     94.1, seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MASCKALGYVHSLESFGSVDGPGVRFVVFLQGCALRCKYCHNPET
                     WAEGGEAWTAEALFQRVYRYRNYWGKKGGITVSGGEPLRQMDFLTEFFTLARAKGVHTA
                     LDTAGQPFRPDDPAYLAAFDRLMANTSLVILDLKEIDPERHRQLTGKDNANILAMARHI
                     SDLGIPLWIRHVLVPGLTDDEEGLRKTADFIRSLKTVQRVEVLPYHTLGLFKWQKLGIP
                     YPLPDAVPPTAEQVKRAEELLEVSRYPG"
     CDS             complement(4695..6947)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Pyruvate2acetate-formate: PFL_acetate2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Gly_radical"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg6_4"
                     /sec_met_domain="Gly_radical (E-value: 1.2e-40, bitscore:
                     129.7, seeds: 99, tool: rule-based-clusters)"
                     /sec_met_domain="PFL_acetate2 (E-value: 4.3e-267, bitscore:
                     878.6, seeds: 33, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIQFEQWEGFEGRIWKEEVNVRDFIQKNYTPYDGDESFLAGPTEA
                     TDKLWGALQQLQKAERAKGGVLDMETEVVSSLTSYGPGYIDENLKDLEQIVGLQTDKPL
                     KRAFMPYGGIKMAEQACTTYGYQPSAELHKIFTDYTRTHNQAVFDAYTPEMKKARHTHI
                     ITGLPDTYGRGRIVGDYRRVALYGIDALIQFKQEDLANCGDGTMTDDVIRLREEIARQI
                     SALKGMKKMAEAYGYDISQPAKNAKEACQWLYFGYLAAIKTQNGAAMSVGRISTFLDIY
                     IQRDLDKGILTESQAQELIDHMVMKFRMVKFARIPSYNQLFSGDPVWATLEVGGIGMDG
                     RSMVTKNCYRFLHTLENMGPAPEPNLTVLYSSALPEAFKKYAAKVSVNTSSVQYENDDV
                     MKPVWGDDYSICCCVSATQTGKEMQFFGARANLAKCLLYAINGGVDEKSHEQCGPNYAP
                     ITSEYLTYDEVLPKYVQMLDWLAGLYVNVLNLIQYMHDKYYYEEAEMALIDTDVRRTFA
                     TGIAGFSHVIDSLSAIKYAKVKVVRDESGLATGFETEGDFPKYGNDDDRADEIGVWLLK
                     TFLEMIKKRHTYRNSEATTSILTITSNVVYGKYTGALPDGRAAFTPFAPGATPSYGAEQ
                     NGLLASLNSVAKLPYHWALDGISNTQTINPEALGHSEGERVENLVQVLDGYFDQGAHHL
                     NVNVFGKEKLLDAMEHPEKEEYANFTIRVSGYAVKFIDLTREQQLDVLARTCHGVL"
     CDS             complement(7527..7985)
                     /locus_tag="ctg6_5"
                     /transl_table=11
                     /translation="MKSFHIPRTALFFILFALAAFAVLYRPIDLKALVRASSQGTLRTE
                     EVAHFGSTNDMDYHLLSMDSEAFQQTAELLSTVSCRKKLNQNYSAYTHDTFPVQSVTVS
                     FYDDAENQKFLLTVYSDGVCILNSAFVSVKYPGGGAAQLYEQLAGLGQ"
     CDS             complement(7990..9027)
                     /locus_tag="ctg6_6"
                     /transl_table=11
                     /translation="MSQAAAQQPSRKKTVISLLVLLALTCIIVFTFKDHWAEITAALAQ
                     LSVWQVLAVLAVGLSYPLLEGCVAWVIVRSRLPQFKLWQGLDVGWCGTFGNVVTLGAGA
                     VPVQLYYLHKAGLPLGPGAGLMTLEYVFHKSTVLLYATVMLLLQHRWLSVNTTGVMRYL
                     PMAYAVVAVIIVALVLLCVSPLVQNLARWLLGFLPKTEKWQQRRADWLEQLEVLGTESR
                     RLLADKPRCLKIFALQALKLFGLFCLPYLCIRFMGLSPLGFWQVQLLTSLMLFVSNALP
                     NVAGMGSIETAFLLVFGSFLEQGEVMSVLMLYRIASYYVVFAASAVGFFIAQRHLAQME
                     LPKEG"
     CDS             complement(9206..10813)
                     /locus_tag="ctg6_7"
                     /transl_table=11
                     /translation="MYTSYSTLQRKQLSKQVYTDTQSTYLLVYAPGRHKALQAALQNQL
                     HRKFRLVTRLEDELTPDVAGVLLVSEDVECTPTALTYFAAALREGADLAVCDASFGFDG
                     STALYLSTRHLPGSSCALVSRALLDKVRAAARGKDSVTELLRLAHAMAQHSRCIPQALL
                     HFRRELCADDVFSAKGRRALILSHELTMTGAPIVLVSAVPVLRSLGFEVVVLGPSDEGS
                     LPLFLDAGAAVVTRPDCVTSSALWGLATSADFVLANTVVEAPVVNTLNGSFVPVLWWLH
                     DAFAGYPFISHSIPKALGKNVHLCAVGSHATAAMHSVRPDFAIEQLIYGLPDYAAEQFP
                     RYDISFAGGRSLFVTVGSLEHRKGPDIFCNAIRLLPSAVREKAAFLFVGKAADKGMYNA
                     VDSLVRDYPQTVFYRKRLERPEVKSLMEQCNCVVCASRDDPMPTFVTEGLIFGKPSIVS
                     EHTGTAGLVTEGVDGFLYKDDDPQQLADKLAWAIEHPEALAAMHGSCRCLYEQQFSNES
                     YVATLTRLVKELTDGEES"
     CDS             complement(10848..11642)
                     /locus_tag="ctg6_8"
                     /transl_table=11
                     /translation="MNHDAPMTPAAMQAHIAELEQQLKLSDEGVSQLAQRCLELEQQLL
                     ACQTELAKHSAEAENITLTLPQLFYDTGSGFSPRECLTATEDVYNELTHEVSVTFVLPE
                     DARAIRLDPGELACCITDLAISDERISFQSVNGLLLQEDSLLFLDVDPNLSLHCTTGFG
                     AGMKFAVNYHYYPLGRFLHEQPGKSLLRALNDLKLESAAAAQEAEEVLQASRAECMRLN
                     QQLLTLQGIQHEYQVSLETMRASSSWRLTAPLRRLLNLVRGH"
     CDS             complement(11709..12824)
                     /locus_tag="ctg6_9"
                     /transl_table=11
                     /translation="METTKPRTVNSIGMFDMLKGAGMLAIVLGHTAELYPLQLEGGLSL
                     TAFVGFIYRETLMAAFFIASGYGFRKRSISKCIHQQLKSLLKPFCYTAVFTTVLHFIIH
                     YKTFHYLPGSMTESIKVAGGFLLGLPHTATYFGQEFFSCGPMWYLLALLMGWILLDVIL
                     NIFPERYIPWAVGGAALLGWGASLVWELPFCLIQGAVITPYLYLGYLAKRQHWLDQPLS
                     RRMSCILWAAVLLIPAAALATRRTDCVSMAEWSLGPISILLDGLAGLLFIRLFLRWSQR
                     RNPLVRFFEAIGRRSLYIFCVHTVELIAIPWYLFAAKYADRPVLGISLQYILSLGSIWL
                     ICALLQRRRDLIIKLFPARRRTPQVHYAPRH"
     CDS             13200..14669
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1025:AMP-binding enzyme (Score: 213.4; E-value:
                     1.5e-65)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg6_10"
                     /sec_met_domain="AMP-binding (E-value: 9.5e-66, bitscore:
                     213.4, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIKVLDNVYDLVTLNMEQRFSERVALRFYDKETDEVTAVHYKDYA
                     RDIRRAVSYFQSTIPDIKGKKICLLNKNSYEYAVNTFGIILAGGVLVLLNQHKSWDELS
                     YELGLVEPAAILTDGDDYGTKEQLQAAYGSILRPMDGFRAYEPVAEMPRCIGHDDLMIL
                     MFTSGTTGRSKGVMLSERNFFSVMRAHVQIGERMMEYKHDPELVVSQYTVLPMFHLGAF
                     ICLFSWAHGGWALNISGDIRNFYKEIRRMPSQVMAVVPVIMNSLHKDVMRGRKERLGEL
                     WVPICSSAMFDPQVMLDMATNGMFVVQTYGATETCGDGIINYAQDAKHIGAVGQGNDYL
                     DYKLEPDGELCIRGDSIMLGYYKDPEATAAVIDKDGWFHTGDLARVDEDGYYYITGRKK
                     NLIILDSGENVSPEELEGMLEKCPAVQECIVKELGKKIGVVVYCEKEHQQTVRDFIAQM
                     NRTVPLYKRIGVVEFSETPLPRNGAGKLVRK"
     CDS             14697..14939
                     /locus_tag="ctg6_11"
                     /transl_table=11
                     /translation="MERAEIISQITAILEDVAEVSPEDVTESSVLMDDLDLSSMEILTI
                     VADLEETFGLRIPEKELRNFVTMGDLVDYLAANVG"
     CDS             14946..16154
                     /locus_tag="ctg6_12"
                     /transl_table=11
                     /translation="METQQRSTEYNFQGIMYFFRREKIQCRYQFSLRDAVDITLLQRAL
                     TAALASAPYYTQRLVQEKREMWLEPNTEPCLVYPGSTMRNIPEQTNGYLFCVSCEGDTV
                     YFDWHHFLLDGHGVSPLLTSILEQYCNLRYGTAFAVPQIVCDPPYDMEAMLAEYPPVEY
                     GSDVIQRDVVQTYEGALRRTRVCLSKQSLVEKALANNAKPVSALMGLLCMAMREYLGKE
                     KIQYSYSSDTRDVAGVPNALYNCVCSFGHTVQLQAQTRLADFVADVDADIRRDLQPQSK
                     RRRMTEQMGWVYKVNQQKAPLRIKQRVFQMGEYIGGTISDFWLSYLGNPLMPATPELAQ
                     YTTDFGVWVPPDGASVGVEAASLNGKIILCIHNKAPNPGLADILRKTFENEGVAVLEAE
                     DLD"
ORIGIN
        1 cacgcctgtt cggcgtgaag atcttttaac cgttttttcc ggctccgccg atttgcagcc
       61 cctcagtcgc tgcgcgacag ctccccccgg ggagcaagcg cagcagctgc cgtttcccgc
      121 cacgacccct cccgtgaaaa tagcgtttgg agcgctccgc agagcgcgac aaacgcgaaa
      181 tttaaaatat tttttccgct gaagatggct agagcgaagc ggaagccatt taaaatcgtc
      241 tcagcgcccc aaacagccca cctttacccg cttttgcaaa aaattgcatt ttccgcaaat
      301 ttgtgcttga caacagaccg actttccgat ataatagagc acgttcccgc ggtaagatgc
      361 cgcacgaact tgagcgatca tggcccggta gctcagttgg ttagagcacc agcctgtcac
      421 gctgggggtc gtcggttcga gcccgatccg ggtcgccatt tgctgctata gctcagttgg
      481 tagagcgcat ccttggtaag gatgaggtct ccagttcgaa tctggatagc agctccaaag
      541 gcaagcacct cgaagtctta ggacttcggg gtgttttttt gcgctttttt cagggcaggg
      601 ggcttgttgc atcctactgc ttgtggaaac cgcccaaaat agaacgactt tttcttccgg
      661 tacgtcaatt gaagctgcct ccaaattgtt atataattaa cataataatg aaatatggca
      721 cagtgctgcg tgtgccgtac tatttttgga ggttttgtat tatggctcgt tttactctgc
      781 cccgtgatct gtaccatggc aagggcgctc tggaagcgct gaaatccttc accggaaaaa
      841 aggcaatgat ctgtgtcggc ggcggctcca tgaagcgctt cggcttcctg gatcgtgccg
      901 tggagtacct gaaggaagcc ggcatggaag tggagctgtt cgagggcatc gaacccgatc
      961 cttccgtgga gaccgtcatg cgcggtgccg aggctatgct gaagtttgag cccgactgga
     1021 tcattgccat gggcggcggc tctcccatcg atgcagccaa ggccatgtgg atcaagtacg
     1081 agtaccccga gatcaccttt gaggagatgt gcaaggtgtt cggcatcccg ccgctgcgcc
     1141 gcaaggcaca cttctgcgcc atttcctcca cctccggcac tgccaccgag gtgaccgctt
     1201 tctccattat caccgactac cagaagggca tcaagtaccc catcgcagac tttgagatca
     1261 ccccggacgt ggccatcgtg gaccccgatc tggctgagac catgcccaag aagctggttg
     1321 cccacaccgg tatggacgcc atgacccatg ccgtggaggc ttatgtttcc accgcacact
     1381 gcgactacac cgacccgctg gccatcttcg ccatccgcat gatccagggc gatctggtgg
     1441 acagctacaa tggcgatatg tccaagcgcg actccatgca caacgcccag tgccttgccg
     1501 gtatggcttt ctccaacgca ctgttgggca tcgtgcactc catggcacac aagaccggcg
     1561 ctgcctttgc agactacggc gcacacatca tccacggtgc tgccaacgcc atgtacctgc
     1621 ctaaggtcat cgccttcaac gccaaggacc ccgaggccaa gaagcgctac ggcgtcatcg
     1681 cagacgagat gaagctgggc ggcgcaaacg atgacgagaa agtcaagctg ctcatcgagt
     1741 acctgcgcgg catgaacgac gccctgaaca tcccccattg catccagcac tacggcccgg
     1801 actcctaccc cactgagcag ggctttgtgc cggagaatgt gttcctcgag cgtctgcccg
     1861 agatcgccaa gaacgccatc gccgacgcct gcaccggctc caacccccgc cagcccagtc
     1921 aggaggagat ggagaagctg ctcaagtgct gctactacga cactgaggtg gatttctgat
     1981 ccgtcctttc tttattacgc ctccttccct atggacaaaa gccccgcaga gcataccgcc
     2041 ctgcggggct tttgccgttt tcgcctgcat tctcccgtga aaaaaggggt tcggaaacgc
     2101 ctacggcgtt tccgaacccc tttcatacta ctaaggtgtt acagcttgct cagctgggga
     2161 ccctgtgcgg tgtccttgac agcccagccc agttcggtca gctgtgcgcg gatggcatcg
     2221 gcggtggccc agtccttggc cttcttggca gcagcacgct tttccaccag ctcagtcacc
     2281 tcggcgggca cctcatcctt tttgcggttg tacagcagac ccagcacacc ggtgatctcg
     2341 tcaaaggcgg cggcagcggt ctccagcgca gccttgctgg aagcggcgga cagggtgttg
     2401 atctccttga ccagatcaaa cacggcagca agcgcatccg gggtgttcag gtcgtcgtcc
     2461 atggcggtgc agaacttggt gcgtgcctct gcggcctttt ccttcaaagt ctcatcggtg
     2521 ccaaagtcgg tcttgctcag ggcaaagtcc agattctcgc ggcaggtgta caggcgctcc
     2581 aggctgttct tgcagctctc gatgaggtct acggtgtagt tcaggggcat gcggtagccg
     2641 gcggtcagca tgaagtagcg gatgggctcg tagccgtaga ggtttgccac atcccgcacg
     2701 gtaaagaagt tgtgcaggct cttggacatt ttctgattgt ccacgttgat gaaaccgttg
     2761 tgcatccagt agcgggcaaa ctcacagcca ttggcgcact cgctctgggc aatctcgttt
     2821 tcgtggtggg ggaagatcag atcctgaccg ccgcagtgca ggtcgatggt cttgcccaga
     2881 tgggtgcggc tcatggcgct gcactcgatg tgccagcccg ggcggcccat gccgtagggg
     2941 ctttcccatg cgggctcacc gggctttgca gccttccaga cggcaaagtc ggcgggatct
     3001 tccttcagat cgtcctccat gcggctgcgc agctcgcggt tgccgctctc cagatcgtcc
     3061 agattcaggt ggctcagctt gccgtagccg gggtcgctct tcacccggaa gtacacatcg
     3121 ccgttcttgg caacgtaggc gtggccggag tcgatcagat ctttgacgat atcgagaatc
     3181 tgagggatgt gctcggtagc gcggggctgc acggtgggct tttcgcagtt cagaccggcg
     3241 gcatccttca ggtactcggc ctcaaagcgc tgggccacct ccttcatgga ggtgccctct
     3301 tcctgcccct tcttgatgag cttatcgtcg atatcagtga tgttggaaac gtagatcacc
     3361 ttgttgcccc ggtattccag atagcggcgc agggtatcga acacgatcag cgggcgtgcg
     3421 ttgccaatgt ggatatagtt gtacacggtg gggccacaga cgtagatgcg gtactcgccg
     3481 ggtacctgcg gtacaaattc ttccttctgt cgggtcaggg tgttgaagat ctgcatggtc
     3541 aattctcctt tttgttccaa acagaagccg caaaacaaaa cgcccccgga gcggtgcgca
     3601 aggcacagct ccgaaggcgg ttttaaaatc aaaatcgcgg ttccacttct gtttgtcgct
     3661 caaagccggt aacggcggcg caccgcacgg cgatacttcc ccacggggtt cccgccgcgt
     3721 gctgtccgag cgcactttgc gcagcggtct gcaaacaggc ttccagccag tggcctgttc
     3781 tctctgcgca gacggtatgc ggcgctactc tgcccggata aacgcattta tccttttacc
     3841 cctttattat agctgtgtgg tgcagggaag tcaaggcaga acgaaccagt gaaaatgaaa
     3901 ttcagccaag cctaccggct tggctgaatt tcaaatcaaa aagatgcttt cctctttacc
     3961 cgggataccg gctcacttcc agcagttctt ctgcccgctt tacctgctct gccgtgggcg
     4021 gtactgcgtc cggcagggga taggggatgc ccagcttctg ccatttgaac agccccaagg
     4081 tgtggtaggg cagcacctcc acccgctgca ccgttttcag gctgcggatg aagtctgctg
     4141 ttttgcgcag cccttcctcg tcatcggtca gcccgggcac gaggacgtgc cggatccaca
     4201 gcgggatgcc gaggtcggag atgtgccgcg ccatggcaag gatgttggcg ttgtccttgc
     4261 cggtgagctg ccggtggcgc tccgggtcga tctccttgag gtctaagatc accagactgg
     4321 tgttagccat cagacggtcg aacgccgcca gataggccgg gtcatccggg cggaaaggct
     4381 gcccggcggt gtccagcgcc gtgtgcacgc ccttggcacg cgccagcgtg aagaactcag
     4441 tcaggaaatc catctgccgc agcggctcgc cgccgctgac cgtgatgccg ccctttttgc
     4501 cccagtagtt gcggtagcgg tatacccgct ggaacagcgc ctctgccgtc cacgcctcgc
     4561 cgccctctgc ccatgtttcg gggttgtggc agtacttgca ccgcagggca cacccctgca
     4621 aaaacaccac aaagcgcacg ccggggccgt ccaccgagcc gaaggattcc agcgagtgga
     4681 cgtacccaag ggccttacag gacgccatgg caggtgcggg ccagcacgtc cagctgctgc
     4741 tcgcgggtca ggtcgatgaa cttgacggcg tagccggaaa cgcggatggt gaagttggcg
     4801 tattcttcct tctcggggtg ctccatggcg tccagcagct tctccttgcc aaagacgttc
     4861 acgttcaggt ggtgtgcgcc ctgatcgaag tagccgtcca gcacctgcac cagattctcc
     4921 acgcgctcgc cctcgctgtg acccagtgcc tcggggttga tggtctgggt gttggagatg
     4981 ccgtccagtg cccagtggta gggcagcttt gccacggagt tcagcgaagc cagcaggccg
     5041 ttctgctctg cgccgtagct gggggtagcg ccgggggcaa acggggtgaa ggcggcgcgg
     5101 ccatccggca gagcgccggt gtacttgccg tacaccacgt tggaggtgat ggtcaggatg
     5161 gaggtggtag cctcggagtt gcggtaggtg tggcgcttct tgatcatctc aaggaaggtc
     5221 ttgagcagcc acacgccgat ctcgtcggcg cggtcgtcat cgttgccgta cttggggaag
     5281 tcgccctcgg tctcaaagcc ggtggcaagg ccgctctcgt cacgcactac cttcaccttg
     5341 gcgtacttga tggcgctcag ggagtcgatg acgtgggaga agcctgcaat gccggtggca
     5401 aaggtgcggc gcacatcggt gtcgatgagt gccatctcgg cttcctcgta gtagtacttg
     5461 tcgtgcatat actggatgag gttcagcacg ttgacgtaca gcccggccag ccagtccagc
     5521 atctgcacat acttgggcag cacctcgtca taggtcaggt actcgctggt gatgggggca
     5581 tagttggggc cgcactgctc gtggctcttc tcgtccacac cgccgttgat ggcgtacagc
     5641 aggcacttgg caaggttggc gcgtgcgccg aagaactgca tctccttgcc ggtctgggtg
     5701 gcagacacgc agcagcagat ggagtaatcg tcgccccaga cgggcttcat cacgtcatcg
     5761 ttctcgtact ggacgctgct ggtgttgacg gacaccttgg cagcgtactt cttaaaggcc
     5821 tccggcaggg cagaggagta cagcacggtc aggttgggct ccggtgcggg gcccatgttt
     5881 tccagcgtgt gcaggaagcg gtagcagttc ttggtgacca tgctgcggcc atccatgcca
     5941 atgccgccca cctccagggt cgcccacacg gggtcgccgg agaacagctg gttgtagctg
     6001 gggatgcggg caaacttgac catgcggaac ttcatgacca tgtggtcgat gagctcctgt
     6061 gcctgacttt cggtcaggat gcccttgtcc agatcgcgct ggatataaat gtcaaggaag
     6121 gtggagatgc ggcccacgct catggcggcg ccgttctggg tcttgatggc ggccagatag
     6181 ccgaagtaca gccactggca ggcctccttg gcgttctttg cgggctgaga gatatcatag
     6241 ccgtaggcct cggccatctt cttcatgccc ttcagggcgc tgatctggcg ggcgatctcc
     6301 tcgcgcagac ggatgacatc gtcggtcatg gtgccgtcgc cgcagttggc aagatcctcc
     6361 tgcttgaact ggatcagggc atcgatgccg tacagggcaa cgcggcggta gtcacccacg
     6421 atgcggccgc ggccgtaggt gtccggcaga ccggtgatga tgtgggtgtg gcgtgccttc
     6481 ttcatctcag gggtgtaggc atcgaacacg gcctgattgt gggtgcgggt gtagtcggta
     6541 aagatcttgt gcagctccgc gctgggctgg tagccgtagg tggtgcaggc ctgctctgcc
     6601 atcttgatgc cgccgtaggg cataaaggcg cgcttgaggg gcttgtcggt ctgtaagcca
     6661 acgatctgct ccagatcctt cagattttcg tcaatatagc cggggccgta ggaggtcagg
     6721 ctgctgacca cctcggtctc catatccagc acgccgccct tggcgcgctc ggccttctgc
     6781 agctgctgca aagcacccca aagcttatcg gtagcctcgg tggggcctgc cagaaagctt
     6841 tcgtcgccgt catagggggt gtagtttttc tggatgaagt cacgcacatt gacctcttcc
     6901 ttccagatgc ggccttcaaa gccttcccac tgttcaaact ggatcattgg aacctccttg
     6961 ctccattatg cggttagcat tttctaacta atgagccttt gaaaaaccgc tctgtctggg
     7021 cggttttctg ggggcgaaac ggtcttgtgc tgccgtctgc ggcagccctt actacaaggt
     7081 gtagacaaaa ataaaaacct gcccacaaaa tcttgcgtta ttataatagc aagaaccact
     7141 ttaaaaagca atagaaaaca agtgggtttt cttccagcgg aaaggctatt ctttgggcag
     7201 aatgtagaaa aacggcagaa accccggcgg cacggcaact ttgcgaaaaa atttgcaaat
     7261 taagggttga caagactaac tgactgtggt atcctgttct cgcagcggcg gttagctaat
     7321 tctaaccacg ttgcaccaga aaaaaggagc gtctgcaagc gctccgctcc attcctccat
     7381 tcctttctct tttctacggg aagtggcagc acggtttgct ctgttgcttc cggcgcggca
     7441 ccggctgtgt ttggtaccac agccgacgca aagaaaacaa aaacgggacg tgcagcttga
     7501 ccaactgcac gccccgtttt ttgtttttac tgccccagcc ccgccagttg ttcatacagc
     7561 tgtgctgcgc cgccgccggg gtattttacg ctgacgaagg cgctgttcag gatgcacacg
     7621 ccgtcggagt acaccgtcag cagaaacttc tgattttcgg catcgtcata aaagctgacg
     7681 gtgaccgact gcaccgggaa ggtatcgtgg gtgtaggcag aatagttctg gttcagtttt
     7741 ttgcggcagg agacggtgga aagcaattct gccgtttgtt ggaacgcttc gctgtccatg
     7801 gagaggaggt gatagtccat gtcgtttgtg ctgccaaaat gcgccacttc ctcggtgcgg
     7861 agcgtgccct gcgagctggc gcgtaccagt gctttcaggt cgatggggcg gtacagcacc
     7921 gcaaaagctg ccagtgcaaa caggataaaa aataaagcgg tgcggggaat gtggaagctt
     7981 ttcatctgct cacccctcct ttggcagttc catttgcgcc agatgccgct gggcgatgaa
     8041 aaagcccacg gcgctggcgg caaataccac ataatagctg gcgatgcggt agagcatcag
     8101 cacgctcatc acctcgcctt gctccagaaa actgccaaac accagcagaa aggccgtttc
     8161 gatcgagccc atcccggcta cattgggcag agcgttggag acgaagagca tcaggctggt
     8221 gagcagctgc acctgccaga agcccagcgg ggaaagcccc atgaatcgga tgcacaggta
     8281 gggcaggcag aacagtccga acagcttgag tgcctgcagg gcaaaaattt tcaggcagcg
     8341 gggcttatct gccagcaggc ggcggctctc ggtgcccagc acctccagct gttccagcca
     8401 gtcggcgcgg cgctgctgcc acttttcggt cttgggcaga aagccaagca gccagcgggc
     8461 gaggttctgc accagcggcg agacgcacag cagcaccagc gccacgataa tcaccgctac
     8521 cacagcgtat gccatgggca gataccgcat gacaccggtg gtgttgacgg aaagccagcg
     8581 atgctgtaac agcagcatca cggtggcgta caagagcacc gtgctcttgt ggaaaacgta
     8641 ttccagcgtc atcagccccg cgccgggacc cagcggcagt ccggccttgt gcaggtagta
     8701 cagctgcacc ggcaccgcac cggcacccag cgtgaccacg ttgccaaagg tgccgcacca
     8761 gcctacatcc agcccctgcc acagtttgaa ctgcggcaga cggctgcgca cgatgaccca
     8821 cgccacgcac ccttccagca gggggtagct gaggccgacc gccagcaccg ccagcacctg
     8881 ccacactgaa agctgtgcca gcgccgcagt gatctcggcc cagtggtcct taaaagtgaa
     8941 cacgatgatg caggtaagtg ccagcagcac cagcagagag atcacggtct ttttgcggga
     9001 gggttgctgc gcggcggctt ggctcatgga aacaaaactc ctttcacaac cggaaattct
     9061 ggaaccagta tagcacatct cccgccgccc tttgtgaacg gaagcggaac tttgttttgc
     9121 aatttggggg atttgataaa atgggaaaac ctctcccgtg aaaaagcact gccgggcagc
     9181 gtgcagctgt ccggcactgt ttttttcatg attcttcccc gtccgtcagc tcttttacca
     9241 gccttgttag ggtggcgaca taggattcgt tggagaactg ctgctcgtac aggcagcggc
     9301 agctgccatg catggcggcc agcgcctccg ggtgttcgat ggcccaggcc agcttgtcgg
     9361 ccagctgctg cgggtcgtcg tccttgtaga ggaagccgtc cacgccttcg gtcaccagcc
     9421 cggcggtgcc ggtgtgctcc gatacgatgg agggcttgcc gaagatcagt ccctctgtga
     9481 cgaaggtggg catggggtca tcccgggagg cgcacaccac gcagttgcac tgctccatca
     9541 gggatttgac ctccgggcgc tccagccgct tgcggtagaa aacggtctgg ggatagtccc
     9601 gcaccaagct gtccacggcg ttgtacatcc ccttgtcggc ggctttgccc acaaaaagga
     9661 aggcagcttt ttcccgcact gcagagggca gcagccggat ggcgttgcag aagatgtccg
     9721 gacccttgcg gtgctccagc gagcctaccg tcacaaagag ggaacgcccc ccggcaaagc
     9781 tgatgtcata gcgggggaat tgctcggctg catagtccgg cagaccgtag atcagctgct
     9841 cgatggcaaa atccggccgg acggagtgca tggcggcggt ggcgtgggag cctacggcgc
     9901 agaggtgcac gtttttgccc agcgccttgg ggatgctgtg ggagatgaag ggatagcccg
     9961 caaaggcatc gtgcagccac cacagcaccg gcacaaagga gccgttcagg gtgtttacca
    10021 ccggtgcttc caccaccgtg ttggccagca caaagtctgc gctggtggcc agcccccaca
    10081 gggcgctgga agtaacgcag tccgggcggg tgaccacagc ggccccggcg tccagaaaca
    10141 gcggcagcga gccttcatcc gagggcccca gcactaccac ctcaaagcct aagctgcgca
    10201 gcaccggcac ggcacttacc agcacgatgg gcgcaccggt catggtcagc tcatggctca
    10261 aaatcagcgc acggcggccc ttggcagaga atacatcgtc ggcacacagc tcccggcgga
    10321 agtgcagcag cgcctgcggg atgcagcggc tgtgctgcgc catggcgtgg gccagacgca
    10381 gcagttcggt aacgctgtcc ttgccccggg cggcggcgcg taccttgtcc agcaatgcgc
    10441 gggacaccag tgcgcagctg ctgccgggca ggtgccgggt gctcaggtac agggcggtgg
    10501 agccgtcaaa gccaaaggag gcgtcgcaga ccgcaaggtc tgcgccctcc cgcagggcgg
    10561 cggcaaaata ggtcagggcg gtgggggtgc actccacatc ctcgcttacc agcagcaccc
    10621 cggctacatc gggggtcagc tcgtcctcaa gccgggtcac cagacggaac ttgcggtgca
    10681 gctggttttg cagcgccgct tgcagcgcct tgtgacgccc cggcgcatag accagaagat
    10741 aggtgctctg ggtatcggta tagacctgct tggacaattg cttgcgctgc agggtactgt
    10801 aactggtgta catgatccaa ctcctccggg cagaatatcg ggcgggctca gtgaccgcgc
    10861 actaggttca gcagtctgcg cagcggggcg gtcagccgcc agctgctgct ggcgcgcatc
    10921 gtttccagcg aaacctgata ttcgtgctgg atgccctgca aggtcagcag ctgctggttc
    10981 agccgcatac actcggcgcg gctggcctgc aatacttcct ctgcctcctg cgcggcagcg
    11041 gcgctctcaa gcttcaggtc gttcagcgcc cgcagcagag acttgccggg ctgctcgtgc
    11101 agaaaacgtc ccagcgggta gtagtgatag ttcaccgcaa acttcatgcc ggcaccaaag
    11161 ccggtggtgc agtgcagcga aaggttgggg tctacgtcca aaaacagcag gctgtcctcc
    11221 tgcagcagaa ggccgttgac cgactggaag ctgatgcgct cgtccgagat ggcaaggtcg
    11281 gtgatgcagc aggccaactc gccggggtcc agccggatgg cgcgtgcgtc ctccggcagg
    11341 acaaaggtga ccgagacctc gtgggtcagt tcgttgtaga catcctcggt ggcagtcagg
    11401 cattcccggg gcgaaaagcc gctgccggtg tcgtagaaca gctgcggcag ggtaagggtg
    11461 atattctcag cctcggcgct gtgcttggca agctcggtct ggcaagccag cagctgctgc
    11521 tccagctcca gacaccgctg cgccagctgg gaaacaccct cgtccgaaag cttgagctgc
    11581 tgctccagct cggcaatgtg cgcctgcatg gcagcagggg tcatgggggc atcgtggttc
    11641 ataacgggat cctcctcttc ctttatccta taacagctgc accgccgcag ccaaaacatt
    11701 cagaaaaatc agtgccgcgg ggcgtaatgt acctgagggg tgcgccgccg ggcggggaac
    11761 aacttgatga tcagatcccg ccgccgctgc agcagggcac agatcagcca gatggagccc
    11821 agcgaaagga tgtattgcag gctgatgccc aaaacagggc ggtcggcgta tttggcggcg
    11881 aacagatacc acggaatggc gatcagctcc accgtatgta cgcagaagat gtacagggaa
    11941 cggcggccga tggcctcgaa aaagcgcacc agcgggttgc ggcgctggct ccagcgcaaa
    12001 aacagccgga taaacagcag accggcaagg ccgtccagca ggatgctgat ggggcccagc
    12061 gaccactcgg ccatggatac acagtcggtg cggcgggtgg caagggcggc tgccgggatc
    12121 agcagtacgg ctgcccacag gatgcaggac atccggcggg acaaaggctg atccagccaa
    12181 tgctgccgtt tggcaaggta gccaaggtac aggtacggcg tgatcaccgc gccctggatc
    12241 aggcagaagg gcagctccca tacaaggctg gcaccccagc ccagcagggc ggcaccgccc
    12301 accgcccaag ggatgtaccg ctccgggaag atgttcagga taacgtccag taagatccag
    12361 cccatcaaca gcgccagcag ataccacatg ggcccgcagg aaaagaactc ctgcccgaag
    12421 taggtggcag tatggggcag acccagcaga aagccgcctg ccaccttgat gctttcagtc
    12481 atggagccgg gcagatagtg aaaggtttta taatgaatga tgaagtgcag caccgtggtg
    12541 aacaccgcag tgtagcaaaa gggcttgagc aggcttttga gctgctggtg gatgcacttg
    12601 ctgatggagc gcttgcggaa gccgtagccg ctggcaataa aaaaggccgc catcagcgtt
    12661 tcgcggtaga taaagccgac aaaggccgtc agcgacaggc cgccctccag ctggagtggg
    12721 taaagctccg cagtgtgtcc cagcacgatg gccagcatcc cagcgccctt gagcatatca
    12781 aacatcccga tggagttgac agtgcggggc ttggttgttt ccatgaaaga ttccttccct
    12841 gcgccgggcc aataccccct cgagaaaaag ccggatacgg cgcaaatgat cagtttttat
    12901 acagcattgc catgatatat ggctagtata atgcttttta tagagactgt caattttgtt
    12961 ttgcagtctg caccataccg gaactggtat tttgcgctaa aaattgtagc acgaaaaccg
    13021 gcggattgca acgaaaggta gaatttggcc ggggcatatc ccaagatgcg caattgaaag
    13081 ttgtcaaagt gagaaattaa atgttgcaga agtattgcat tgcattggaa aatattgtat
    13141 actgagcaca gtacagcgca ctgccgcagg atgaaataac aacgcaggag gaaaatacaa
    13201 tgatcaaggt attggacaac gtgtatgatc tggtcaccct gaatatggaa cagcgttttt
    13261 cggagcgtgt ggcgctccgc ttttatgata aggaaacgga cgaggtgacc gcagtccatt
    13321 ataaggacta cgcgcgggac atccgccgtg cggtcagcta cttccagagc accatcccgg
    13381 atatcaaggg caaaaagatc tgcctgctga ataaaaacag ctacgaatat gccgtgaaca
    13441 ccttcggcat cattctggcg ggcggtgtgc tggtactgct caaccagcac aagagctggg
    13501 acgagctgtc ctacgagctg gggctggtgg aacccgctgc catcctgacc gacggcgacg
    13561 actacggcac aaaagagcag ctgcaggccg cctacggcag catcctgcgc cccatggacg
    13621 gcttccgcgc ttatgagccg gtggcagaga tgccccgctg catcggccac gatgacctga
    13681 tgatcctgat gttcacctcc ggcaccaccg gccgcagcaa gggcgtgatg ctgagcgagc
    13741 gcaacttctt cagcgtgatg cgcgcccatg tgcagatcgg tgagcgcatg atggagtata
    13801 agcacgaccc ggagcttgtg gtcagccagt acacggtgct gcccatgttc catctgggcg
    13861 cattcatctg cctgttctct tgggcacacg ggggctgggc gctgaacatc agcggcgata
    13921 tccgcaattt ctataaggag atccggcgga tgcccagtca ggtcatggcg gtggtgccgg
    13981 tgatcatgaa ctccctgcac aaggacgtga tgcgcggccg caaggagcgc ttgggcgagc
    14041 tgtgggtgcc catctgctcc tctgccatgt ttgacccgca ggtgatgctg gatatggcca
    14101 ccaacgggat gttcgtggtg cagacctacg gcgctaccga gacctgcggc gatggcatca
    14161 tcaactacgc gcaggatgca aagcacatcg gcgctgtggg acagggcaac gattatctgg
    14221 actacaagct cgagccggac ggagagctgt gcatccgggg tgacagcatc atgctgggct
    14281 actacaagga ccctgaggcc accgctgcgg tcatcgacaa ggacggctgg ttccacaccg
    14341 gcgaccttgc ccgggtggac gaggacggct actactacat taccggccgc aagaagaatc
    14401 tgatcattct ggacagcggc gagaacgtca gtcccgagga actggaaggc atgctggaaa
    14461 aatgtcccgc cgtgcaggaa tgtatcgtaa aagaactggg caaaaagata ggtgttgtgg
    14521 tatactgtga aaaggagcac cagcagacgg tgcgggactt tattgcccag atgaaccgca
    14581 ccgtcccgct gtacaagcgc attggcgtgg tggaattcag cgaaacgccg ctgccccgca
    14641 acggcgcagg caagctggtg cgcaagtaaa acgcaacaga aaggaagcat aatacgatgg
    14701 aacgtgcaga aatcatttct cagatcacgg ctattctgga ggatgtcgca gaggtatcgc
    14761 cggaggatgt gaccgaaagc agcgtcctga tggacgatct ggatctgtcc tctatggaga
    14821 tcctgaccat tgtggcagat cttgaggaga cctttggcct gcgcatcccg gaaaaggagc
    14881 tgcgcaactt tgtcaccatg ggggatctgg tggattatct ggcagcaaac gtggggtaaa
    14941 aaccaatgga aacacagcag cgctcgacgg aatataactt tcagggaatc atgtactttt
    15001 tccgtcggga aaagatccag tgccggtacc agttctcgct gcgggatgcg gtggatatca
    15061 cccttttgca gcgggcactg acagcggcct tggcaagtgc gccctattat acccagcgtc
    15121 tggtgcagga aaagcgggag atgtggctgg agcccaatac ggagccctgc cttgtgtacc
    15181 ccggcagcac catgcgcaat atcccggaac agacgaacgg ctacctgttc tgcgtcagct
    15241 gcgaagggga taccgtctac tttgactggc atcacttcct gctggacggc cacggggtat
    15301 cgcccctgct caccagcatt ctggagcagt actgcaacct gcgttacggc acggcctttg
    15361 cggtgccgca gatcgtgtgc gacccgccct atgatatgga ggccatgctg gcagagtacc
    15421 cgcctgtgga gtacgggagc gatgtcatcc agcgggatgt ggtgcagacc tacgagggtg
    15481 cgctgcgccg cacccgggtg tgcctgagca agcagagcct tgtggaaaaa gcgctggcga
    15541 acaacgcaaa gccggtaagc gctctgatgg gtctgctgtg tatggccatg cgggagtatc
    15601 tgggcaagga gaagatccag tattcctact cctccgatac ccgcgatgtg gccggtgtgc
    15661 cgaatgcgct gtacaactgc gtatgcagct ttgggcatac ggtgcagctg caagcccaga
    15721 cccgcctggc agattttgtg gctgatgtag atgcagacat caggcgggat ctgcagccgc
    15781 agtccaagcg ccgccgcatg accgagcaga tgggctgggt gtacaaggtg aaccagcaaa
    15841 aggcacccct gcgcatcaag cagcgggtgt ttcagatggg cgagtacatc ggcggcacca
    15901 tttcggactt ctggctcagc tatctgggca atccgctcat gcccgccact ccggaactgg
    15961 cacagtacac cacggatttt ggcgtctggg tgccgccgga cggtgcatcc gtgggtgtgg
    16021 aggctgccag cctgaacgga aagatcatcc tatgcatcca caacaaggca cccaacccgg
    16081 gtctggctga tatcctccgc aagacctttg aaaacgaagg cgttgcggtg ctggaagccg
    16141 aagatctgga ctgagaaata cttattataa aagaaaaaac tgctgcacgt tttgtgcggc
    16201 agtttttttg ctgctttttg taagaaaatc cggttgcaaa gatgcgaaaa aatggttaaa
    16261 tagagaaagg atatttccgc aaggagagga acaccatgga acaacagaac acgcgcctgc
    16321 gcaatgcggg ctttgcgacc tttttcttca gcggcatctg cgccatcagc gcgggtgtgg
    16381 tggtcagtct gctgcaggag cgctatggct ttgcctacgg catgaccggt acgctgctct
    16441 ccctgatgag catcggcaac ctgctggcgg ggctgctgat ggggatgctg cccagtgcgc
    16501 tgggcatgaa gcgcagtgtg ctgctgctga ccatcggcta tgcggcgggc tatgccgtca
    16561 tgggactgac cggcgcagtg gcgctgctgg cagcggcctt ttttgtggta ggcatcgcca
    16621 agggcagcgt tatcaacacc tgtaccattc tggtcagcga tcattctgcc gaccgcaccc
    16681 ggggcatgaa cctgatgcac agctgctacg cctgcggcgc actgctgtgc cccttcctca
    16741 ttgcggcggc agcccgggta agcaccgagc tggcggtctt tctgctggca gccgtgggcc
    16801 ttgtgctctg gctggtgtac gtctttaccc cgctgcgcgg cggcaagagt aaaagcaacg
    16861 cagagaaaga atccatcgac tggagctttc tgcgctctgc ccgtttctgg ctgcttaccg
    16921 ggctgctgtt cttccagaac gccgccg
//
