LOCUS       c00088_gnlPro..        11439 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|DKKCNBAO_88.
ACCESSION   c00088_gnlPro..
VERSION     c00088_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 21:08:33
            Original ID  :: gnl|Prokka|DKKCNBAO_88
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 11439
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..756
                     /locus_tag="ctg88_1"
                     /transl_table=11
                     /translation="KYVFLSMKKNLFFLFALICSMSLFTACSDDDDDKIKDPVIGTWKV
                     PAVELDENNSVGSVFMTWEAPEDTYLSFLPVSAIPSLAIQMGSVILPQVLQDVTLSADG
                     NIVATYSSAGIDLSGEKPITPVWETSPADYATFKLQGNGKMLLFLNLEKIIADANTKAD
                     ITTVISQLLELVKNGIPVNYALSNNNEEVKIFIDKELMTTIAAMGPAIAELIPDALGSF
                     GPMIKAILGDLPTAMSKTTKFELGLNLKK"
     protocluster    1..11439
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[3344:9426]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      3345..9426
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..11439
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..11439
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             903..2183
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SDH_alpha"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg88_2"
                     /sec_met_domain="SDH_alpha (E-value: 1.6e-62, bitscore:
                     200.7, seeds: 645, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKTERQQIIDLVKSEVVPAIGCTEPIAVALCVAKAAEVLGRHPE
                     KITVLLSANILKNAMGVGIPGTGMIGLPIAVALGALIGKSEYQLEVLKDCNPDAVEEGR
                     RFIDEKRIHIALKDGIKEKLYVEVCCEVGDEKSTAIIAGGHTSFVYMARNGEVLLNKQA
                     VASTEKEEGALDLSLRKVYDFALTAPLDEIRFILETARLNKAAAESSFEGDYGHGLGKI
                     LRGTYEHKVMGDSVFSHILSYTSGACDARMAGAMIPVMSNSGSGNQGISATLPVLIYAE
                     ENGKSEEELIRALMLSHLTVIYIKQSLGRLSALCGCVVAATGSSCGITWLMGGTYEQVA
                     YAVQNMIANLTGMICDGAKPSCALKVTTGVSTAVLSAIMAMENRCVTSVEGIIDEDVDQ
                     SIRNLTKIGSKGMNETDKLVLEIMTSK"
     CDS             complement(2283..2855)
                     /locus_tag="ctg88_3"
                     /transl_table=11
                     /translation="METVENKYITVAYKLYSIENGEKDFEEEAPVEHPFQFISGLGMTL
                     EPFEAQIKDLQIGDKFDFTIPASEAYGEYDDDHVIDLPKEIFMIEGEFDSDRVVEGAVI
                     PLMTSEGQRINGSVVEVKEDIVVMDMNHPLAGCDLNFTGEVVESRLATNEELAEVARMM
                     GGGCGSCGCGDCGDGCGDHECGGGCCH"
     CDS             3345..5147
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ILVD_EDD"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg88_4"
                     /sec_met_domain="ILVD_EDD (E-value: 2.4e-219, bitscore:
                     718.4, seeds: 918, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKHQLRSSFSTQGRRMAGARALWTANGMKKEQMGKPIIAIVNSFT
                     QFVPGHVHLHEIGQFVKEEIEKLGCFAAEFNTIAIDDGIAMGHDGMLYSLPSRDIIADS
                     VEYMVNAHKADAMVCISNCDKITPGMLMAAMRLNIPTVFVSGGPMEAGEWNGQHLDLID
                     AMIKSADESVGDKEVAQIEQHACPTCGCCSGMFTANSMNCLNEAIGLALPGNGTIVATH
                     ENRKKLFEDAARLIVENAFRYYEEGDESVLPRSIATREAFLNAMTLDIAMGGSTNTVLH
                     LLAVAHEAGADFKMDDIDMLSRKTPCLCKVAPNTQKYHVQDVNRAGGIIAIMDELAKGG
                     LVDTNVRRVDGMTLAEAIDRYSITSSNVCKEAIKKYSSAAAGKFNLVLGSQNASYKELD
                     TDRATGCIRDLEHAYSKDGGLAVLKGNIAQDGCVVKTAGVDESIWKFTGPAKVFDSQDA
                     ACDGILGGKVVSGDVVVITHEGPKGGPGMQEMLYPTSYIKSRHLGKECALITDGRFSGG
                     TSGLSIGHVSPEAAAGGNIGKIKDGDIIEIDIPNRSINVKLTDEELAARLMTPVTRNRE
                     VSKALKAYASMVSSADKGAVRLID"
     CDS             5239..6990
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg88_5"
                     /sec_met_domain="TPP_enzyme_C (E-value: 7.6e-48, bitscore:
                     151.4, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MADNNKKSNFSSLSQGEGRGEALITGAEALMRSLEHQGVKTIFGY
                     PGGSIMPVFDALYDHRKELNHILVRHEQGATHAAQGFARVSGEVGVCLVTSGPGATNTI
                     TGIADAMIDSTPIVVIAGQVGTNFLGTDAFQEVDLVGITQPITKWSYQIRRAEDVAWAV
                     ARAFYVAKSGRPGPVVLDFAKNAQVEKTEYAPTKVDYVRSYLPVPEMEPEAIRKAAELI
                     NGAERPLVLVGQGVELGEAQQELRAFIEKAGMPAGCTLLGLSALPTNHPLNKGMLGMHG
                     NLGPNINTNKCDVLIAVGMRFDDRVTGKLETYAKQAKIIHFDIDPAEIDKNVKTDVAVL
                     GDCKETLAAVTQLLEPANHQEWIDSFRQYEEVEEEKVIRPELHPAGKALSMGEVVRAVS
                     EATHNEAILVTDVGQNQMMSARYFKYSKERSIVTSGGLGTMGFGLPAAIGATFGRPDRT
                     VCVFMGDGGLQMNLQELGTIMEQKAPVKMILLNNNFLGNVRQWQAMFFNRRYSFTPMMN
                     PDYMKIASAYDIPARRVMTREELAKAIDEMIATDGPFLLEACVEEEGNVMPMTPPGGSV
                     NQMLLEC"
     CDS             7023..7583
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg88_6"
                     /sec_met_domain="ALS_ss_C (E-value: 5.4e-20, bitscore:
                     60.8, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKKLYTIIVHSENFAGLLNQVTAVFTRRQINIESLNVSASSIKG
                     VHKYTITAWTDKDTIEKVTKQITKKIDVLQAHYFTDDEIYQHEIALYKITTPTLEEKPE
                     VSKVIRKYNARIVEVNAVFAIVEKNGMSEEITNLYEELRQLDCVLQFVRSGRVAITTSC
                     FERVNEYLADREAKYRQSKHQES"
     CDS             7580..8332
                     /locus_tag="ctg88_7"
                     /transl_table=11
                     /translation="MMSENNKIGTYKFVAEPFHVDFTGRLTMGVLGNHLLNCAGFHASD
                     RGFGIATLNEDNYTWVLSRLAVELDEMPYQYEDFSIQTWVENVYRLFTDRNFAIIDKEG
                     KKIGYARSVWAMISMNTRKPADLLALHSGSIVDYVCDEPCPIEKPSRIKVASKEPVAAL
                     VAKYSDIDINGHVNSIRYIEHILDLFPIEMYKEKRIRRFEMAYVAESYYGDELTLFMDD
                     AGEGVYDVEVKKNGSEVVCRSKVIFTEK"
     CDS             8383..9426
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg88_8"
                     /sec_met_domain="IlvN (E-value: 3.5e-47, bitscore: 149.3,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 3.1e-41, bitscore: 130.3,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQLNFGGVIENVMTREEFPLEKAREILKDETIAVIGYGVQGPGQ
                     ACNLRDNGFNVIVGQRPGKTYEKAVADGWVPGETLFGIEEACQKGTIVMCLLSDAAVMS
                     VWPTIKPYLTPGKALYFSHGFAITWNDRTGVVPPKDIDVIMVAPKGSGTSLRTMFLEGR
                     GLNSSYAVYQDATGKAFDKTIALGIGIGSGYLFETTFIREATSDLTGERGSLMGAIQGL
                     LLAQYEVLRENGHTPSEAFNETVEELTQSLMPLFAKNGMDWMYANCSTTAQRGALDWMT
                     PFHDAIKPVVQKLYASVKSGNEAQISIDSNSKPDYREKLNAELKALRESEMWQTAVTVR
                     KLRPENN"
     CDS             complement(9488..11437)
                     /locus_tag="ctg88_9"
                     /transl_table=11
                     /translation="NKIKHFFCRKRRMITFATMKEQDSNSPIIHLQQQQLLLRMEYEYE
                     KEEFKRQTENMGVARKVKRGLCWYPATPGRSYYNSLNQLVIEITHTENTDIEHNFEFGR
                     PVCFFRQSADGKITYMNFTATVSYADETRMVAIMPGAGAVMEVQETDNLGVQLYFDETS
                     YRTMFEALEDTLRSKGNRLAELRDILLGTSKAGFRELYPVRFPWLNSTQETAVNKVLCA
                     RDVAIVHGPPGTGKTTTLVEAIYETLHREPQVLVCAQSNTAVDWISEKLVDRGVNVLRI
                     GNPTRVNDKMLSFTYERRFENHPLYPELWSIRKNLRELGSRARRGSYDEREGVRSRMSR
                     LRDRATALEIQINAELFDGAHVIASTLVSSNHRLLNGRRFGTLFIDEAAQALEAACWIA
                     IRKADRVVLAGDHCQLPPTIKCHEAARGGLERTLMEKVVSNKPAVVSLLKVQYRMHEEI
                     MKFPSQWFYNGELEAAPEVRYRGILDWDTPIHWIDTSEMDFKEEFVGETFGRINKAEAD
                     LLLSELKIYINRIGGNRILEEKIDIGIISPYKAQVQYLRSKIKADASLKPYRSLFTVNT
                     VDGFQGQERDVIFISLVRANEEGQIGFLNDLRRMNVAITRARMKLVILGEAETLKHHGF
                     YRKLLEFIQNIGNQ"
ORIGIN
        1 aaatatgttt ttttaagtat gaaaaagaat ttgttttttt tatttgcgtt gatttgctct
       61 atgagtttgt tcactgcttg tagtgatgac gacgatgata agattaaaga cccggttatt
      121 ggtacttgga aagttccggc tgttgaattg gatgaaaata attcggtggg tagtgttttt
      181 atgacatggg aggcacctga ggacacatat ctatcatttt tgccggtaag tgctattccg
      241 tcgttagcta tacagatggg gtctgtgata ttgccgcagg tattgcagga tgttactttg
      301 agtgctgacg gtaatatagt ggccacttat tcttctgcag ggatagatct ttcaggtgag
      361 aagccaataa ctccggtatg ggagacttca ccggcagatt atgcaacctt taaattgcag
      421 gggaatggta aaatgttgct tttcctgaat ctggaaaaaa taatagccga tgctaatact
      481 aaagctgata taactactgt tatatctcaa ttgttggaac ttgtgaagaa tggaatccct
      541 gtgaattatg cgttgtctaa taataatgaa gaagtgaaaa tctttattga taaagaactt
      601 atgactacta ttgctgctat gggaccggca attgcagaat tgattcctga tgcattaggt
      661 agttttggtc ctatgataaa agctatattg ggagaccttc cgactgcaat gtcaaaaact
      721 acaaagtttg aattgggttt gaatttgaaa aagtaatcta atttagacag gaagataaca
      781 acttaagata gggaatccca ctattaagca atgtcttaat agtgggattt attttattcc
      841 ttctattcct tctattatag aataaaatac attacctttg tctgcatcta aattgaataa
      901 atatgacaaa aacggaaaga caacagatta ttgatttggt taaatccgag gtcgttcctg
      961 ctataggttg cacagaacct atagctgtgg cattgtgtgt ggcaaaagct gcggaagtat
     1021 tgggcagaca tccggaaaag ataacggttc ttttaagtgc caatatcttg aagaacgcga
     1081 tgggcgtagg aattcccggt acaggaatga ttgggctgcc tattgcagta gcgcttggtg
     1141 ccttaatcgg taaatcggaa tatcaactgg aggtattgaa ggattgtaat cccgatgccg
     1201 tggaagaagg aagacgtttt atagatgaaa agcgcatcca tatagcactg aaagatggca
     1261 ttaaagagaa gctttatgtt gaagtttgtt gtgaggtcgg ggatgaaaag tccactgcta
     1321 tcattgcagg tggacacact tcctttgtat acatggcacg caatggggaa gtgctgttga
     1381 acaagcaggc tgttgcaagc acagaaaagg aggaaggtgc gctggattta agcttgcgga
     1441 aagtctatga ttttgctttg acggctccgt tggacgaaat tcgttttatc ctcgaaacgg
     1501 cccgtctgaa taaggctgcc gcagaaagct cttttgaggg tgattacgga catggcttgg
     1561 gaaaaatcct tcgtggtact tacgagcata aggttatggg ggacagtgtt ttttcccata
     1621 ttctttctta tacttccggt gcttgcgatg cccgtatggc aggagccatg attccggtca
     1681 tgagtaattc aggaagcggt aatcaaggta tatccgctac gttgccggtt ttgatttatg
     1741 ccgaagaaaa cgggaaatca gaagaagaat tgattcgtgc cttgatgttg agccatttga
     1801 cagtaatcta tatcaagcag agtttgggac ggttatccgc cttatgcggt tgtgtggttg
     1861 ctgccactgg ttccagttgc ggtataactt ggctaatggg gggtacttat gagcaggtgg
     1921 catatgctgt acagaacatg attgccaatc ttaccggaat gatttgtgat ggtgccaaac
     1981 ctagttgtgc attgaaagtg actaccggag tttcaaccgc agtactttca gccatcatgg
     2041 ccatggaaaa ccgttgtgta acttccgtag aaggtattat tgatgaggat gtggatcaga
     2101 gtatccgtaa tctgacaaaa atcggttcta aaggaatgaa tgaaacggat aaattggtat
     2161 tggagataat gacaagtaaa taattaaaaa aatgaagaat taaaaatgaa agaattatca
     2221 tgcagcatac ttatattgcg tagtttgatt ctttcatttt taattcttca tttttaattc
     2281 ttctagtggc agcatccgcc tccacattca tggtcgccgc atccgtcgcc acagtcacca
     2341 caaccgcagc tgccgcaacc gccacccatc atacgggcga cttcggcaag ttcttcgttt
     2401 gtagccaggc ggctttccac tacttctcca gtgaagttca agtcacaacc tgcgagcgga
     2461 tggttcatat ccattacgac gatatcttcc ttcacttcta ccacacttcc gttgatgcgt
     2521 tgaccttcag aagtcatcaa ggggataacg gcaccttcta ctacacgatc gctgtcgaat
     2581 tctccttcta tcatgaagat ttctttgggg aggtcaataa catggtcgtc gtcatattca
     2641 ccataagctt ctgatgccgg aatggtaaag tcgaatttat cgcctatctg caagtctttt
     2701 atctgggctt caaagggttc gagtgtcatt cccagacctg agataaactg aaaaggatgc
     2761 tctacgggtg cttcttcttc gaaatctttt tctccgtttt cgattgagta cagcttatat
     2821 gctacggtga tgtacttgtt ttctactgtt tccattaatt ttctatcttt atttaattag
     2881 taaatacttt tttttgagta tttgaagaga caaagatacg aattatttgt ttcgggatgt
     2941 agagagcctt tggtaatttt cagattatta aatggtttca atgattggca atacatttac
     3001 attggctgtc tgaatggttc tatttagaac tgttaagtga taaaatagga ttttagggcg
     3061 atattttctt acgattattc atatttatct tatttttttc ttcaatttgt ttggagatta
     3121 taaaaaagcc cttacctttg cagcacgttt gaaacaaaaa agaagaatta agttatgaat
     3181 ttacatacat ctattaacct ggcagtcctg catattattc gcgtcgtggt ggtggcatca
     3241 agagcgtgag aaaggttatg tatgtattcg tacgttagaa gataatttat taagcctttc
     3301 tcactatagt gggagaggct ttttcattaa aaggagattt gaaaatgaag catcagttac
     3361 gcagctcgtt cagcacacaa ggtcgccgca tggcgggagc ccgtgcattg tggacggcga
     3421 atggtatgaa gaaggaacag atgggtaagc ccattatcgc tatagtcaat tcatttacac
     3481 aattcgtccc cgggcatgta cacctgcacg aaataggcca gtttgtaaag gaagagattg
     3541 aaaaactggg gtgttttgct gcggagttca atacgattgc cattgacgac ggtatcgcta
     3601 tgggacacga cggtatgctt tattccctgc cttcaagaga tatcattgcc gatagtgtgg
     3661 agtatatggt aaatgcccat aaggcagatg ctatggtttg catcagtaac tgtgacaaga
     3721 ttactccggg gatgctgatg gcggctatga ggctgaatat accgactgtg tttgtttcag
     3781 gcggtccgat ggaagccggg gaatggaacg gacagcattt ggatttgatt gatgccatga
     3841 ttaaatctgc tgatgaaagt gtgggcgata aagaggtggc acagattgag caacatgcct
     3901 gccccacttg cggatgctgc tcaggcatgt ttaccgctaa ttccatgaat tgcttgaatg
     3961 aagcgattgg attggcactg cccggtaacg gcacgattgt agccactcac gaaaatcgca
     4021 agaaactatt tgaggatgca gccaggttga ttgtagagaa tgcctttaga tattatgaag
     4081 aaggggatga gagtgtactc ccgcgcagta ttgctacccg cgaggcattt ttgaatgcca
     4141 tgacgctgga tattgcgatg ggcggttcca ctaatacggt acttcatttg ttggctgtgg
     4201 ctcacgaagc cggagcggat tttaagatgg acgatattga catgctctcc cgcaagaccc
     4261 cctgcttatg caaggtggct cccaataccc aaaagtatca tgtacaagac gttaaccgtg
     4321 ccggtggcat cattgccatc atggatgagc ttgccaaggg cggattggtc gatacgaatg
     4381 tccgccgtgt ggatggaatg acgttggcag aggcaatcga ccggtatagt attaccagct
     4441 ctaatgtatg taaagaggca atcaagaaat actccagtgc ggcagccgga aagttcaatc
     4501 tggtactcgg ctcacaaaat gcgtcttata aggaactcga tacggaccgt gcgaccggtt
     4561 gtatccgtga tttggaacat gcatacagca aggatggcgg tctggcggtt ttgaagggaa
     4621 atatagctca ggacggttgc gttgtcaaga ctgccggtgt agacgagagt atctggaaat
     4681 ttacggggcc agcgaaagtc ttcgactcac aagatgcggc ttgtgacggt attctgggtg
     4741 gaaaggtggt cagtggagac gtcgtcgtca tcactcacga agggccgaaa ggtggaccgg
     4801 gtatgcaaga gatgctttat cctacttctt atatcaaatc ccgccatctg ggtaaggagt
     4861 gtgcattgat taccgacggg cgtttcagtg gtggtacttc cggactaagt atcggacatg
     4921 tttctcccga agcggctgcc ggtggtaata tcggcaagat taaggatggg gacattatcg
     4981 aaattgatat accgaaccgt tctatcaatg tgaagttgac ggatgaagag cttgcagcac
     5041 gccttatgac tccggtaacc cgcaaccgtg aagtctccaa agcattgaaa gcatatgcca
     5101 gtatggtgag ttccgctgac aaaggggctg tgaggctgat tgattaaaag cccccctttc
     5161 cgaaagcgag gggaggagag aatgaaacaa atttttcaag ctactattga gcttttaaat
     5221 ataatgaata gataaagtat ggctgataat aataaaaaga gtaacttttc ctccctctcc
     5281 caaggagagg gtcggggtga ggctctaata acaggcgcag aagcattgat gcgctctctg
     5341 gagcatcagg gagtaaagac tattttcggt tatccgggag ggagcatcat gccggtattc
     5401 gatgccttat acgaccaccg gaaggaattg aaccacatct tggttcgcca tgaacaagga
     5461 gcaacccatg cggcacaagg ctttgcacgt gtatcaggcg aggttggcgt ttgtctggtt
     5521 accagtggac cgggtgctac caatactatc acgggcattg cagatgccat gattgacagt
     5581 acgcctatcg ttgtcattgc cggccaggta gggacgaact tcttgggtac ggatgcattt
     5641 caggaagtgg acttggtagg cattactcag cctatcacga aatggagtta ccagattcgt
     5701 cgtgcagaag atgtggcctg ggcagtggca cgtgctttct atgtggcaaa gagcggacgt
     5761 ccgggaccgg tcgtgctgga ttttgctaaa aacgcccaag tggagaaaac agaatatgcg
     5821 cctactaagg tggactatgt ccgtagctat cttcccgttc ccgaaatgga gccggaggcc
     5881 atacggaagg ctgctgaatt aataaatggt gcggaacggc ctttggtgct ggtaggacaa
     5941 ggcgtggagc tgggagaagc ccagcaagag cttcgtgctt tcattgagaa agccggaatg
     6001 cctgccggat gcactttatt gggactttcc gcattaccta cgaaccatcc gttgaacaaa
     6061 ggaatgcttg gtatgcacgg taacctgggg cccaatatca ataccaataa atgtgatgtc
     6121 cttatcgccg taggcatgcg ctttgatgac cgtgtgacgg gtaaattgga aacatatgcc
     6181 aagcaggcga agattatcca ctttgatatt gaccctgccg aaatagataa gaatgtaaag
     6241 accgatgttg ctgtcctggg agattgcaaa gagacactgg ctgccgttac ccaattgctg
     6301 gaacccgcca accatcagga atggattgac agtttccggc aatacgagga agtggaagag
     6361 gaaaaggtaa tccgtccgga attacatccg gcaggaaaag cgctaagcat gggtgaggtg
     6421 gtgcgtgctg tgagtgaggc tacccataac gaggcgatat tggtgactga tgtcggccag
     6481 aatcagatga tgtccgcccg ttatttcaaa tacagcaagg aacgtagcat tgttacttcc
     6541 ggtggcctgg gtactatggg cttcggcctt ccggcagcta tcggtgccac ttttggacgt
     6601 ccggaccgca cggtatgcgt attcatggga gacggcggct tgcagatgaa cctgcaggaa
     6661 ctgggtacca tcatggaaca aaaggctccg gtgaagatga ttctgttgaa caataacttc
     6721 ctgggcaatg ttcgtcaatg gcaggcgatg ttcttcaatc gtcgttattc gtttactccg
     6781 atgatgaatc cggattatat gaagattgct tcggcatatg atattcctgc acgcagggta
     6841 atgacccgcg aggagctggc aaaagcgatt gacgagatga tagcaaccga cggaccgttc
     6901 ctgctcgaag cttgtgtgga ggaagaagga aatgtaatgc cgatgacacc tccgggcggt
     6961 tcggtcaatc agatgttgtt ggaatgctga agtcatgcga aattaaagaa tttactctat
     7021 ctatggataa aaaactatat acaatcattg ttcattcgga aaactttgcc ggtttgctga
     7081 atcaagtgac ggctgtgttt acccgtcggc agataaacat cgaaagttta aatgtatcgg
     7141 cctcctccat caagggggta cataaatata ccattaccgc ttggacggac aaggatacca
     7201 ttgaaaaggt gaccaagcag attaccaaga aaatagatgt gctgcaagcc cattatttta
     7261 cggatgatga aatctatcag cacgagattg ctctctataa aataacgacc cctacgctgg
     7321 aagaaaaacc ggaggtgtcc aaagtaatcc gtaagtacaa tgcccgtatt gtggaggtga
     7381 atgctgtatt tgccattgtt gagaagaatg gcatgagtga ggaaataacc aatctttatg
     7441 aggagttgcg ccagttggat tgcgtacttc agttcgtccg ttcgggtcgc gtagccatta
     7501 cgaccagctg ctttgagcgt gtcaatgaat atctggcgga ccgtgaagca aaatatcgtc
     7561 aaagtaaaca ccaggaatca tgatgagcga gaacaataag ataggtacct acaagtttgt
     7621 tgccgaaccg tttcatgtcg actttaccgg acggctgaca atgggagtat tgggcaacca
     7681 tttgttgaat tgtgcgggtt tccatgccag cgaccgcggt tttggcatcg cgactctaaa
     7741 cgaggacaat tatacttggg tattgtcccg tctggctgtc gaactggatg aaatgcctta
     7801 tcagtacgaa gatttctcca ttcagacttg ggtggagaat gtctatcgcc tttttacaga
     7861 ccgtaatttc gctatcatcg ataaggaggg taagaagatt gggtatgcac gttccgtttg
     7921 ggcgatgatt agcatgaata cccgtaagcc ggcagatttg ctggctcttc atagtggcag
     7981 cattgtagat tatgtttgcg atgagccttg cccgatagaa aaaccttcgc ggataaaggt
     8041 ggcctcaaag gaaccggttg ctgctttggt agccaaatac agtgatattg acattaacgg
     8101 gcatgtgaac agcatccgtt acatcgagca tatccttgat ttgttcccga tagagatgta
     8161 taaggagaag cgcatccgtc gttttgaaat ggcatatgta gccgaaagct attatgggga
     8221 tgagttgact ttgttcatgg atgatgccgg tgagggcgtt tacgatgtgg aggtgaaaaa
     8281 gaatggcagc gaagtggtct gtcgttctaa agtgatattt acagagaaat aaataaattt
     8341 atcaacgttg gcgtaagcca caaataaaaa ttaaaacaaa aaatggcaca attgaatttt
     8401 ggcggtgtta ttgagaatgt aatgacccgc gaagaatttc ctttggaaaa agcacgtgag
     8461 attttgaaag atgaaacaat tgcagtaatc ggttatggcg tacaaggccc gggccaggct
     8521 tgcaacttgc gtgataacgg tttcaatgtg attgtaggac aacgtccggg taagacatac
     8581 gaaaaggctg tggctgacgg atgggtaccg ggtgagactt tgttcggcat cgaagaggct
     8641 tgtcagaaag gtactatcgt catgtgtctg ttgtctgacg cagctgtaat gtctgtatgg
     8701 ccgactatca aaccttattt gactcccggg aaggctcttt acttctctca tggttttgct
     8761 attacctgga acgaccgtac cggcgtggtt cctcctaaag atattgatgt tattatggtt
     8821 gctcccaaag gttccggtac ttcacttcgt accatgttcc tcgaagggcg tggcttgaac
     8881 tcatcatatg ccgtctatca agatgctacg ggtaaggctt ttgacaagac gattgcactg
     8941 ggtatcggta tcggttcggg atatttgttc gagacaactt tcatccgcga agccacttcc
     9001 gacttgaccg gtgaacgcgg ttcattgatg ggtgctatcc agggattact gttggctcag
     9061 tatgaagtat tgcgcgaaaa cggccatact ccttctgaag cattcaatga aactgtggaa
     9121 gagttgactc aatctttgat gccattgttt gccaagaatg gtatggactg gatgtatgcc
     9181 aactgttcta ctacggcaca gcgtggtgcg ctggattgga tgaccccgtt ccatgatgcc
     9241 atcaagccgg ttgtacagaa attgtatgca agtgtgaagt cgggcaacga agcccagatt
     9301 tctatcgaca gtaactccaa acccgattat cgtgagaagc tgaatgcaga attgaaagcc
     9361 ttgcgtgaaa gcgaaatgtg gcagacagct gttacagttc gtaaacttcg tccggaaaac
     9421 aattaatcag ctttatataa ataggtgaaa taccctcttc ggtgttaccg gagggggtat
     9481 ttctttatta ttgattccct atattttgaa taaactccaa tagcttccgg taaaaaccgt
     9541 gatgtttcag cgtctctgcc tctcccaata tcaccagctt catacgtgcc cgggtgatgg
     9601 ctacattcat tctccttaaa tcattcagga atcctatctg tccttcttcg ttggcacgga
     9661 caaggctgat gaagataaca tcgcgctctt gcccttggaa gccatccacc gtatttacag
     9721 tgaacaagct gcgataaggc ttgagtgaag cgtctgcctt tatcttgcta cggagatatt
     9781 gcacttgtgc cttgtaaggg gagatgatgc cgatgtctat tttttcttcc agaatgcggt
     9841 tgccaccgat acggttgatg tagattttca gttctgatag gagcaggtcc gcttccgcct
     9901 tattaatgcg tccgaaagtc tctcccacaa attcttcttt gaaatccatt tcggaggtgt
     9961 caatccagtg gatgggggta tcccagtcca ggatgccccg gtaacgcact tcgggagcgg
    10021 cttccaactc gccattataa aaccattggg aaggaaattt catgatttcc tcgtgcatgc
    10081 ggtattgcac tttcagcaaa gagacaacgg caggtttgtt ggacaccact ttctccatca
    10141 atgttcgttc cagacctcca cgggcggctt cgtggcattt tatggtgggc ggaagttggc
    10201 agtggtcacc cgccaatacc acgcggtctg cttttcggat agctatccag caggcagcct
    10261 ctaaggcctg ggctgcttca tcaatgaaaa gggtgccgaa acggcgtccg ttcagcagcc
    10321 ggtgattgct gcttaccagc gtggaggcta tgacgtgtgc cccatcaaaa agctctgcat
    10381 tgatttgtat ttccaatgcg gtggcgcggt cgcgcaggcg gctcatacgg ctgcgtactc
    10441 cttcgcgttc gtcatagctg ccacggcggg cacggctgcc cagttcacgg agatttttcc
    10501 ggatgctcca cagttccgga taaagcggat ggttctcgaa acgacgctcg taggtaaagg
    10561 aaagcatctt gtcgttgaca cgggtcggat tgccgatacg caggacattg acgccacggt
    10621 ccacaagttt ttccgaaatc cagtcgacgg cagtattgct ttgggcacat actagtacct
    10681 gcggttcccg atgcagggtt tcatagatgg cttccactaa ggtggtcgtt tttccggttc
    10741 ccggaggacc atgtacaatg gccacgtcgc gggcacacag cactttgttt acagctgtct
    10801 cctgcgtgga gttcagccag ggaaaccgta cggggtagag ctctcggaaa ccggctttcg
    10861 aggttcccag caatatgtcc cgcaattcgg ccaggcggtt gcctttggag cgtaacgtat
    10921 cttccaaggc ttcgaacatg gtccgatagg atgtttcgtc gaaataaagt tgcacgccga
    10981 ggttgtccgt ttcctgcact tccataacgg caccggctcc gggcattatc gctaccatcc
    11041 gtgtctcgtc ggcatagctt acggtagcgg tgaagttcat ataggttatt tttccatcgg
    11101 cagactggcg gaaaaaacat acgggacggc cgaactcaaa attatgttct atatcggtat
    11161 tttctgtgtg tgtaatttct attactaatt gattcagtga attatagtaa cttcgtcccg
    11221 gagtggcagg ataccagcaa agtccccgtt tcactttccg ggcaaccccc atgttttcgg
    11281 tttggcgttt gaattcctct ttttcgtatt cgtattccat gcgcagcaaa agttgttgct
    11341 gctggaggtg aataatagga ctatttgaat cttgttcctt catggttgca aaggtaatca
    11401 ttcttcgctt ccgacagaaa aaatgcttta ttttgttaa
//
