LOCUS       c00044_gnlPro..        14133 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|KCMHMAGB_44.
ACCESSION   c00044_gnlPro..
VERSION     c00044_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 21:58:51
            Original ID  :: gnl|Prokka|KCMHMAGB_44
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14133
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14133
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2574:9487]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      2575..9487
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..14133
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14133
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             complement(168..554)
                     /locus_tag="ctg44_1"
                     /transl_table=11
                     /translation="MEVVNTVGRRKAAVARVYVKPGKGQITINRKALEVYFPLEILQYQ
                     VKQPLLATNTAENYDIVINLDGGGITGQASAARLGIARALCEIDAEMRPVLKKAGFLTR
                     DSREVERKKPGQPGARRKFQFSKR"
     CDS             complement(560..1015)
                     /locus_tag="ctg44_2"
                     /transl_table=11
                     /translation="VDSLSYKTISANAATVTKEWVVIDATNEVLGRLASQVAKILRGKN
                     KPSYTPHVDCGDYVIVINAEKVKLTGNKMTDKVYTRHTGYPGGQRFATPADYLAKKPTF
                     LIEKAVKGMLPKTRLGDKLLSNLKVYAGAEHPHAAQNPKTIKLNEIK"
     CDS             complement(1240..2436)
                     /locus_tag="ctg44_3"
                     /transl_table=11
                     /translation="MKRLFMVLFGLASLHAAATAAKTAGEEKTPGKNAGAAASLWPEKM
                     DPSFQGSRPECFKIWVIRNLRFPADRYDVGDEAKVEVVFAIDKNGTLTDLKVTHCEERH
                     FADRLCKTIALSPKWSPGRTKGKPVKTELEMRFVFRLVAPPAGQEELGLCAEECDIHTT
                     ADRMPLFCGGGPDGFRAWVQRQVDSLMGPGALTEPRKLILRFVVGKDGRVTPAPKPKYR
                     DEDALEQTVRQAIAAAPAWTPATIDGERVRFGVSMPVAFGPGAAGAEYSDKDAYRVVEV
                     MPKFFGGGLDKFRSWVMAEVRYPSDMLKRGVQGRVVAAFIVDKEGRITMVEILESPHPQ
                     FSEAVARVLGRAPRWTPGRQDGALVRVEYTLPVDFKIRSELRFPSGAAGRNRGSSRSY"
     CDS             complement(2575..3786)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg44_4"
                     /sec_met_domain="OAD_beta (E-value: 3.7e-169, bitscore:
                     552.1, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MWNALTSSSNFVLESLETFAESTGVAGLIANMGWGSLIMICVAFF
                     LLYLAIKHKFEPLLLLTIAFGMLLTNLPGANLYHTELFAGGHVHWDIFVAQAGLLDYLY
                     LGVKLGIYPCLIFVGVGAMTDFGPLIANPKSFLLGAAAQLGIFLTFIGAYALGFSPAEA
                     GSIGIIGGADGPTSIYLTAILAPELLGPIAVAAYSYMALVPVIQPPIMRMLTTEKERKI
                     KMRQLRPVSKTEKILFPLIITVIIALLLPSAAPLVGCLMLGNLMKECGVVDRLSKTVQN
                     ELMNIVVIFLGLTVGATATAEAFLNPRTLFILVLGVIAFAMGTAGGVLLAKVMNFFSKG
                     DNKINPLIGSAGVSAVPMAARVSQTEGQKADPSNFLLMHAMGPNVAGVVGSAVAAGILL
                     SFLG"
     CDS             complement(3791..4252)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 71.2; E-value:
                     1.6e-22)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg44_5"
                     /sec_met_domain="Biotin_lipoyl (E-value: 3.8e-23, bitscore:
                     71.2, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKDYSLKINGHNYNVQIDDVNEASTVAHVVVNGVDYEVEIEGAKA
                     STVSKPQVSPAPKSANSAMITPSTATPSPRIAPAPSTSGSSVKCPLPGTVLSVKVAVGD
                     TVAAGQTLVVLEAMKMENNIDADRAGVVKQILVQQGATVMEGDVLIVIG"
     CDS             complement(4289..4609)
                     /locus_tag="ctg44_6"
                     /transl_table=11
                     /translation="MNWGWSEILWVSLIGFSLVFILLVALIFIMKAFGACFRVRPASGR
                     KVDAQPMISEEEIAAIATALKIYKGALHDRESEVLTILNIKRAYSPWNSKIHGLTQLPD
                     RR"
     CDS             complement(4640..6205)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Btheta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg44_7"
                     /sec_met_domain="CT_Btheta (E-value: 2.4e-286, bitscore:
                     939.8, seeds: 72, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSQIQEKINKLIENRETARLGGGQKAIDKQHDKGKYTARERIQML
                     LDEGSFEEFDMFVTHRCYDFGMDRKHTFGDGVVTGYGTIDGRLVYVFAQDFTVTAGSLS
                     LSMSDKICKVMDMAMRNGAPCIGMNDSGGARIQEGVNALAGYANIFQRNVMSSGVIPQI
                     SAIFGPCAGGAVYSPALTDFIIMKKETSNMFLTGPKVVKTVTGEDVTQEQLGGALMHTT
                     KSGVAQFAVDTEEEGIGLIKKLISYMPQNNMEDAPLAVCTDKITRLEDSLNEIIPDSAN
                     KPYDMTEVIKAIVDNGEFLESAAGYAKNIITCFARFNGQSVGIIANQPKFMAGVLDINA
                     SRKAARFVRFCDAFNIPIVTLVDVPGFLPGTTQEYGGVITHGAKLLFAYCEATVPKITV
                     TLRKAYGGAYIVMSSKHIRGDINYAWPTAEIAVMGASGAVEVLYGKELKELADKPEEKA
                     KFIAEKEQEYNDKFSNPYNAARYGYIDDVIEPRNTRFRVIRALQSLATKRLQNPAKKHS
                     NIPL"
     CDS             complement(6210..6620)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Glyoxalase_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg44_8"
                     /sec_met_domain="Glyoxalase_4 (E-value: 3.9e-27, bitscore:
                     84.8, seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKVSHIEHLGVAVKSLDEAIPYWENVLGLKCYAIEEVADQKVRTA
                     FFMLGQTKIELLEPTSEDSTIAKYIENRGVGIHHMALACENIEEQLADAEAKGIRLIDK
                     TPRKGAEGMTIAFLHPKSTQGILTELCENKNK"
     CDS             complement(6831..7820)
                     /locus_tag="ctg44_9"
                     /transl_table=11
                     /translation="MKIGLDTAPAALRGTYFQHLASVLARYAPEHEYIIGAEVNDGVDL
                     YHGFRSSLPLSVHLRRVPSVMTVPNLNFLRYPHLYTFAERLFVLTLYRRALRRAGRVIT
                     VSTPAREELSERLNIDPSKIEVMVPLAVPAPRGNPSQAELEHVRRKYALPEHFILMIGT
                     VEPRHNHQAVFAALADAASPAGVVVCGRRTAWSDYLLGYARARRIAARVDFIYELTPSD
                     LPALFRLARVFAYLPDADAEASVVPVVEALRAGLPMVLSDTQVNREAAGEAAAYVRPEA
                     RGEVLAALENALEDVSWRRTMQERERRRAELFSEYAVAERLMQIYTSL"
     CDS             7892..8356
                     /locus_tag="ctg44_10"
                     /transl_table=11
                     /translation="MKKMLLIWLLAAGFASAGATAQNIALGERVPELKIQTWLDNRQPE
                     PAPTTYIEFFHSTNPACKTSLERLKEITGKSGTKLRVIVVTKEAPAKIAPLLRPYLSER
                     ISVGLNAEKSFTAFGVSYLPFGVLTDAKNRTLWMGNSLQINEKLIEQSTR"
     CDS             8363..9487
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: MeaB"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg44_11"
                     /sec_met_domain="MeaB (E-value: 1.9e-101, bitscore: 328.5,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSFTRIDHYEKEYADTHHDTALNVTQGVEEQPIVSPYFKRRKKRV
                     LSTGEYVEGILAGNITTLSQAITLVESSNPDHYAQAQEIIEACLPHAGKSVRIGITGVP
                     GAGKSTFIEAIGNMVAGLRHKLAVLAIDPSSERSGGSILGDKTRMESICNNPSVFVRPS
                     PSAGSLGGVARKTRETIVLCEAAGFDVIFIETVGVGQSETAVHSMVDLFMLLQISGAGD
                     ELQGIKRGIMEMADLMVITKADGENIHKAELAQTQFQGALRLFPVPESGWRPKVYTSSA
                     VARTGLEEVWKGVEEYLDHIQKNGYFQHNRNRQNKYWMYESINEALRGSFYRDPAVEAC
                     IGAYEKRVLEDKISSFIAAKELLEIYFKDARTLE"
     CDS             9571..10410
                     /locus_tag="ctg44_12"
                     /transl_table=11
                     /translation="MKQGRFYLAAAILLLASGCEKEDGENTGDSKWTHPLTTTLHRTDP
                     GGEQSTYVITYTYDAKDRLTGTRNSRDGVTETTTSDYVYDGKTVTYTEKTWAGETLWNS
                     QKFKRTYLDDALEKVLEERITDKDDHIIQRICNEYDQQERLVHSLEYSRGNSKVSETKY
                     TYDGKLVICDKYWLKNTGEVSAVSKYIITYSDDELTKPLIHGCLAAEETAERPWDWVRH
                     YSYDYRGRLNGITYEAEGKLVWETRNYVYGNKSLTCENREVHYGTDIITISETTYKH"
     CDS             complement(10789..11520)
                     /locus_tag="ctg44_13"
                     /transl_table=11
                     /translation="MKKLVVFTGAGVSADSGLATFRDSDGTWGNYRIEEVCIPEALDFN
                     RRGVIRFYNERRAEMLKAEPNAAHRAIAGLERDFDVRVITQNVDNLHERAGSTHILHLH
                     GELTKLRSTDDPSLILPFDGVEQGFDDRAPDGSLLRPHIVFFGEPVPEFDRAAELAAGA
                     DILMVVGTSLAVYPAASLVRCVRPDIPVYVVDPGRPAIRGVRNPLEVIRKRAAEGVPEL
                     ADRLRAACAEGRSESLLPGKA"
     CDS             11615..13030
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyridoxal_deC"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg44_14"
                     /sec_met_domain="Pyridoxal_deC (E-value: 7.1e-65, bitscore:
                     209.0, seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDQQKHTTEDTLTDIFGSKEMRSPAPTEFIPKNKTAPEIAYQLVK
                     DETYPQTQPRLNLATFVTTYMDDYATRLMNEAININYIDETEYPRVAVMCGRCLNIVAN
                     MWNSPEKAEWKTGALGIGSSEACMLGGVAAWLRWRARRKAAGKPFDKPNLVMSTGFQVV
                     WEKFCQLWQIEMRTVPLTLDHPTLDIGEALKACDENTICIVPIAGVTWTGLDDDIEGLD
                     KALDAYNAKTGYEIPIHVDAASGGFILPFLHPEKKWDFRLKWVLSISTSGHKYGLVYPG
                     LGWVVWKDKKYLPDEMSFSVNYLGANITQVGLNFSRPAAQILGQYYNFIRLGFEGYKEV
                     QQNSMDIAKYCHEQIGKMPCFRNYAKEVVNPLFIWMMDPEYDKKAKWTLFDLQAALQQS
                     GWMVPAYTMPKNIDEMIVMRIVVRQGMSRDMADMLLGDIRNAVAEFEKLRYPTPSRIKY
                     ENKEHQKGKVYTH"
     CDS             13467..14132
                     /locus_tag="ctg44_15"
                     /transl_table=11
                     /translation="MKENFDIFLIVMALLAAVVYAALHFFEAGYGYLFDRRYGPPVPNR
                     VGWMVMESPVFILMCVLWASSERMWQAGPLALFCLFQAHYLQRAFIFPLLIRGKGRMPL
                     GIVVMGMVFNTLNALMQGGWIFYVSPADYYAGWFAQPYIYIGGALFVAGMAVNLHSDHI
                     IRHLRRPGDTRHYIPRGGMFRYVSSANYFGELLEWVGFAVASWSWAGTVFAWWTFANLA
                     "
ORIGIN
        1 tcctggtagc ggcctggccg gtcccgggga gttttccgcg gcgcggcaac cagatagtag
       61 actaattaaa aattaagaat taaaaatgaa aaattcccaa tatataataa gtatccatgt
      121 ggtttgagaa ccgtcgccgt gcgttgccga aattccggtc gtgcgtatta acgcttgctg
      181 aactggaact tgcggcgtgc accgggctga ccgggcttct tacgctcaac ctcgcgggaa
      241 tcgcgcgtga ggaatccggc cttcttcagc accggacgca tctccgcgtc gatttcgcac
      301 agtgcgcgtg cgatgcccag acgagcggcc gaagcctgtc ccgtgatacc accgccatcg
      361 aggttgatga cgatgtcgta attctccgcc gtgttggtgg ccagcagggg ctgcttcacc
      421 tggtattgga gaatttcgag cgggaagtaa acttcaagcg ctttgcggtt gattgtaatc
      481 tgacccttgc ccggcttcac gtatacgcga gccacagcgg ccttacgacg acctacggtg
      541 tttacaactt ccataactct tacttaatct cgtttaattt aatagtcttc gggttctgtg
      601 cggcgtgggg atgctctgcg ccggcataga ccttcaggtt cgacagcagc ttgtcgccca
      661 gacgggtctt gggcagcatg cctttgacgg ccttctcgat gaggaaggtc ggtttctttg
      721 ccagatagtc ggcaggcgta gcgaaacgct ggccgccggg gtatccggtg tgacgcgtgt
      781 agaccttgtc ggtcattttg ttgcccgtga gcttcacctt ctccgcgttg atgacgatga
      841 cgtagtcacc acagtcgacg tggggtgtgt agctgggctt gttcttgcct cggaggatct
      901 tcgcgacctg cgatgcaaga cgtcccaata cctcgttcgt agcgtcgatc accacccatt
      961 ccttggtgac ggtcgcagcg ttcgccgaga tagtcttgta gcttaatgaa tccactgttt
     1021 ttacgtttaa tttaacttat tgtaatccgt tccccgcaca ttgcgggtgc gcaaaggtac
     1081 gaaaaagttt ctgatctgca aaaacaaatg aaaatcaaaa tcgaaaaccg cgcaaaaaaa
     1141 ccgcaacggc cccgtattca ggagagttgc ggcattccga agcaggagcg cggcgttagc
     1201 gggcgccctt ggcaggcagg cggcaggcgg gcggctgtgt caatacgaac gggatgaacc
     1261 ccggttccgg ccggcggcgc cgctcgggaa ccgcagttcc gagcgaattt tgaaatcgac
     1321 cggcagcgtg tattccaccc ggacgagcgc accgtcctgc ctgcccggcg tccaccgcgg
     1381 cgcacgtcca agcacacgag cgaccgcttc cgaaaattgc ggatgcggcg actcgagaat
     1441 ctccaccatc gtaatccgcc cctccttgtc gacgatgaat gccgcgacca cacgcccctg
     1501 cacgccccgt ttcagcatgt ccgacgggta cctcacttca gccatcaccc aactccggaa
     1561 tttatccagc ccgcctccga agaacttcgg catgacctcg accacccggt aagcgtcctt
     1621 atcgctgtat tccgctccgg cggccccggg accgaaggcg accggcatcg agaccccgaa
     1681 acgaacccgc tctccgtcaa tcgtcgccgg agtccacgca ggagccgcgg caatggcctg
     1741 acgcaccgtc tgttccaaag catcttcgtc ccggtatttc ggtttggggg caggagtcac
     1801 ccgcccgtcc tttccgacga caaaccgcag gatcagtttc cgcggctccg tgagcgcacc
     1861 cggacccatc aggctgtcga cctgccgctg cacccacgca cgaaacccgt ccggaccgcc
     1921 gccgcagaac aggggcatcc tatcggccgt cgtatggatg tcgcactcct cggcgcaaag
     1981 ccccagctcc tcctgtcccg caggaggggc gaccagccgg aagacgaatc gcatctccag
     2041 ctccgttttt acaggtttcc ccttcgtccg tccgggcgac catttcggcg acagggcgat
     2101 cgtcttgcag agccggtcgg caaaatgccg ctcctcgcaa tgcgtgacct tcagatcggt
     2161 cagcgtcccg tttttgtcga tggcgaacac aacttcgacc ttcgcctcat ccccgacatc
     2221 gtagcgatcg gccggaaacc gcaggttgcg gatcacccag attttgaagc attccggacg
     2281 gcttccctga aaagaggggt ccatcttttc gggccaaagg ctggccgccg caccggcgtt
     2341 ttttccgggg gtcttttcct ctccggcggt tttcgcggcg gtcgcagccg catgcagcga
     2401 cgcaaggccg aaaagcacca taaacaagcg tttcataata aggcaggagt tttaggtttc
     2461 ataaatatag cgaaaaatgc gagacttgca acggcacagg cgcaaaaaag agggtccggc
     2521 gaaccgaaac cctcttgcaa ccgtatcggg ccgtgcggcc cggaacgcga ttccctatcc
     2581 gaggaacgaa agcagaatgc ccgcggcgac cgccgaaccg accacgccgg ccacgttggg
     2641 acccatggcg tgcatcagca ggaagttcga gggatcggcc ttctggccct cggtctgcga
     2701 cacgcgggcg gccatcggga cggccgaaac gccggccgaa ccgatcagcg gattgatctt
     2761 gttgtcgccc ttcgagaaga agttcatcac cttggcgagc agcacgccgc cggcggttcc
     2821 catcgcgaag gcgatcacgc ccagcacgag gatgaacagc gtccgcggat tgaggaacgc
     2881 ctcggccgta gccgtagctc ctaccgtgag acccaggaag atgacgacaa tgttcatcag
     2941 ttcgttctgc accgtcttcg acagacggtc caccacgccg cactccttca tcaggttgcc
     3001 cagcatgaga cagccgacga gcggagcggc cgacggcagc agcagcgcga tgatcacggt
     3061 gatgatcagc gggaagagga tcttctcggt cttcgacacc ggacgcagct ggcgcatctt
     3121 gatcttacgc tccttctcgg tggtcagcat gcgcatgatc ggcggctgga tcaccggcac
     3181 gagggccatg taggagtagg cggccacggc gatcgggccg agcagctcgg gagccagaat
     3241 cgcggtcagg tagatcgacg tgggaccgtc ggcgccgccg atgatgccga tcgaaccggc
     3301 ctcggctggc gagaatccga gcgcataagc gccgatgaac gtgaggaaaa taccaagctg
     3361 cgccgcggct cccagcagga agctcttggg gttggcgatc agcgggccga agtcggtcat
     3421 ggcgcccacg cccacgaaga taaggcaggg atagatgccg agcttcacgc ccagatagag
     3481 gtaatcgagg agtcccgcct gggcgacgaa aatatcccag tggacgtgcc ccccggcaaa
     3541 aagttccgta tggtagaggt tcgctccggg aaggttcgtc agcagcatgc cgaacgcgat
     3601 ggtcagcagc agcagcggtt cgaacttatg tttgatggcc aggtacagca gaaagaaggc
     3661 cacacagatc ataatcagac tgccccaccc catgttggct atcagaccgg ccacgcccgt
     3721 cgattcggca aaggtttcaa ggctttccag cacgaaattg gagctggaag tcaatgcatt
     3781 ccacatagtc ctacccgatt acgattaaaa cgtcgccttc catgaccgta gcgccctgct
     3841 gcacgagaat ctgcttcacg acaccggcgc ggtcggcgtc gatgttgttc tccatcttca
     3901 tggcttcgag cacgacgagc gtctgtcctg ctgcgacggt atcgcccacg gccaccttca
     3961 cgctcaacac ggtgcccggc agcgggcatt tcacgctgga acccgacgtc gaaggcgcgg
     4021 gagcgatgcg cggcgaagga gtggccgtcg agggagtgat catggcgctg ttggccgact
     4081 tgggggccgg ggacacctgg ggtttggaga ccgtcgaggc tttcgcgccc tcgatctcga
     4141 cttcgtaatc cacgccgttg accacgacgt gcgctaccgt cgaggcctcg ttcacgtcgt
     4201 cgatctggac gttgtaatta tgtccgttga ttttcaaaga gtaatctttc attttctttt
     4261 ttgggttgtc ttgttccgac gcagggtcct atctccggtc gggaagctgg gttaaaccgt
     4321 gaattttcga attccagggc gaataggccc gcttgatgtt gagaatggtc agcacctcgg
     4381 actcgcggtc gtgcagggcg cccttgtaga tcttgagcgc cgtagcgatg gctgcgatct
     4441 cctcctcgct gatcatcggc tgggcgtcga ccttcctgcc gctcgccgga cggacccgga
     4501 agcaggcccc gaaggccttc ataatgaaga tcagcgccac cagcaggata aacaccaggc
     4561 tgaacccgat cagcgacacc cagagtatct cggaccatcc ccagttcata actgtcagta
     4621 ttgtcatctt ttcagtctgt tagagaggaa tgttcgaatg tttcttcgcg gggttctgca
     4681 aacgcttcgt agccagcgac tgcaaggcgc ggatcacacg gaaacgcgtg ttgcgcggct
     4741 cgatcacgtc gtcgatatag ccgtagcgtg cggcgttgta ggggttggag aacttgtcgt
     4801 tgtactcctg ctccttctcg gcgatgaact tcgccttctc ctccggtttg tcggccagct
     4861 ccttcagctc cttgccgtag agcacctcga cggcgccgct ggcgcccatc acggcgatct
     4921 cggccgtcgg ccatgcgtag ttgatgtcgc cgcggatgtg cttcgacgac atgacgatgt
     4981 atgcgcctcc gtaagccttg cgcagcgtca cggtgatctt cggcacggtg gcctcgcagt
     5041 aggcgaacag cagcttcgcg ccgtgggtga tcacgccgcc gtactcctgg gtcgtacccg
     5101 gcaggaagcc cggaacgtcc accagcgtca cgatcggaat gttgaacgcg tcgcagaaac
     5161 gcacgaagcg cgcagccttg cggctggcgt tgatgtccag cacgccggcc atgaacttgg
     5221 gctggttggc gatgatgccc accgactggc cgttgaaacg cgcgaagcag gtgatgatgt
     5281 tcttggcata gcctgcggcc gattcgagga actcgccgtt gtcgacgatg gccttgatca
     5341 cctcggtcat gtcgtagggc ttgttggcgc tgtcgggaat gatctcgttg agcgaatcct
     5401 ccagacgggt gatcttatcg gtgcagacgg ccagcggagc gtcctccatg ttgttctgcg
     5461 gcatgtagga gatcagcttc ttgatcagcc cgataccctc ctcctcggtg tcgacggcga
     5521 actgcgccac gcccgacttg gtggtgtgca tcagggcgcc gcccagctgc tcctgcgtca
     5581 cgtcctcgcc cgtcacggtc ttcacgacct tcgggccggt gaggaacatg ttcgaggtct
     5641 ccttcttcat aatgatgaag tcggtcagcg cgggcgaata gaccgcaccg cctgcgcagg
     5701 ggccgaagat ggccgaaatc tgcggaatga cgcccgacga catcacgttg cgctggaaga
     5761 tgttggcgta accggccagg gcgttgacgc cctcctggat acgcgcgccg cccgagtcgt
     5821 tcatgccgat gcagggcgcg ccgttgcgca tggccatgtc catcaccttg cagatcttgt
     5881 cggacatcga cagcgacagc gaaccggccg tcacggtgaa atcctgtgcg aagacataaa
     5941 ccagacgtcc gtcgatcgtg ccgtaacccg tcaccacgcc gtcgccgaag gtgtgcttgc
     6001 gatccatgcc gaaatcgtag cagcggtggg tcacaaacat atcgaactcc tcgaacgaac
     6061 cttcgtcgag gagcatctga atacgctcgc gggccgtgta cttgccctta tcgtgctgtt
     6121 tgtcgatcgc cttctggccg ccgccgagac gcgcggtttc gcggttctcg atcagtttgt
     6181 tgatcttttc ctgtatctgg ctcataatcc tatttgtttt tgttttcgca aagctccgtc
     6241 agaatgccct gggtcgattt cgggtgcagg aaggcgatgg tcatgccctc ggcgcccttg
     6301 cggggggtct tgtcgatcag acggatgccc ttggcctccg cgtcggcgag ctgctcctcg
     6361 atgttttcgc aggccagcgc catgtggtga atgccgacgc cgcggttctc gatgtacttt
     6421 gcgatcgtcg aatcctccga agtcggctcc agcaattcga tcttggtctg ccccagcatg
     6481 aagaacgccg tgcggacctt ctggtcggcg acctcctcga tggcatagca cttcaggccc
     6541 aatacgttct cccagtaggg aatcgcctcg tcgagactct tcacggcaac gccaagatgc
     6601 tcgatatgag aaactttcat agcaaaattt aaatttaagt tagtggatat tcgtatgttg
     6661 tttcgttcgt tgttattttg cgaacacaaa gatagacgaa tctttcagaa ccgccaaaat
     6721 tcggagtact ttttttggca ataacttcgg gttcggaatt cgcaggaaat gtccggaaag
     6781 gcgattcgtt ccggcggagc ctccggcggc ctgcggttcg aaagccgggg ttacagcgac
     6841 gtgtaaatct gcatcagccg ttccgccacg gcgtattcgg agaacagttc ggcgcggcgg
     6901 cgttcgcgct cctgcatcgt gcggcgccac gacacgtctt ccaacgcgtt ttcgagcgcc
     6961 gcgagaacct cgccccgcgc ctccggacgc acataggcgg cggcctctcc ggcggcttcg
     7021 cggttgacct gcgtgtcgct caagaccatc ggcagacccg cccgcagggc ctcgaccacg
     7081 gggacgaccg acgcctcggc atcggcgtcg ggcagatagg cgaagacccg cgccagacgg
     7141 aacagcgccg gaaggtccga aggggtcagt tcgtagatga aatccacccg tgcggcgatg
     7201 cggcgggcgc gggcatagcc cagcagatag tcggaccagg ccgtgcggcg gccgcagacg
     7261 accaccccgg ccggggacgc agcgtcggcc agagccgcga aaaccgcctg atggttgtgc
     7321 cgcggttcga cggttcctat catcaatata aaatgctctg gaagagcata cttgcggcgc
     7381 acatgttcaa gttccgcttg agatggattt ccgcgcggag ccggaaccgc cagcggcacc
     7441 atgacctcga tcttcgaagg gtcgatattg aggcgttccg acagctcctc gcgggccgga
     7501 gtgctgaccg tgatgacccg gccggcccgc cggagcgcac ggcggtagag cgtcaggacg
     7561 aaaagccgtt cggcaaacgt atagagatgc ggatagcgca ggaaattgag attcgggacc
     7621 gtcatcaccg aaggcacgcg ccgcagatgc acggacaacg gcagcgacga cctaaagccg
     7681 tggtagaggt caacaccatc attcacctct gcgccaatga tatattcatg ctccggagcg
     7741 tagcgcgcca gcacgctggc gaggtgctgg aagtaagtcc cgcggagtgc ggcgggagcc
     7801 gtgtcgagtc ctattttcat aacttgattc taaaaaattg gtccatatgc caaataattg
     7861 ttatctttat cgaataaaac aaggctctct tatgaagaaa atgctgctta tatggctgtt
     7921 ggccgcgggt ttcgcatccg cgggagccac ggcccagaac atcgccctcg gcgaacgcgt
     7981 tcccgaactc aaaatccaga cgtggctcga caaccgccag cccgaaccgg ccccgacgac
     8041 ctacatcgaa tttttccatt cgacgaatcc cgcgtgcaaa acctcgctcg aacgcctgaa
     8101 ggaaatcacg ggcaaatcgg gtaccaaact gcgcgtgatc gtcgtgacga aggaggcccc
     8161 cgcgaaaata gccccgctgc tgcgccccta cctctcggaa cggatctccg tgggcctcaa
     8221 cgccgaaaag agtttcacgg cgttcggcgt cagctacctg ccgttcggcg tgctgaccga
     8281 cgccaagaac cgcaccctct ggatgggcaa ttccctgcaa atcaacgaaa aactgatcga
     8341 acaatcaaca cgctgacaca ccatgtcgtt caccaggata gaccattacg aaaaagagta
     8401 cgcagacacg catcacgaca cagccctcaa cgtcacgcaa ggcgttgaag aacaaccgat
     8461 agtaagccct tacttcaagc ggcgcaagaa gcgcgtgctc tccaccggag agtacgtcga
     8521 gggcattctc gcgggcaaca tcaccaccct ctcgcaggcc atcacgctcg tcgaatcgtc
     8581 gaaccccgac cactatgcac aggcgcagga gatcatcgaa gcgtgcctcc cgcacgccgg
     8641 gaaatcggtc cgcatcggca tcacgggcgt cccgggagcc ggcaaatcga ccttcatcga
     8701 agccatcggc aacatggtcg cggggctgcg ccacaagctg gcggtgctgg ccatagaccc
     8761 ttcgtcggag cgcagcggcg gctcgattct cggcgacaaa acccgcatgg agagcatctg
     8821 caacaaccct tcggtcttcg tgaggccctc gccctcggcg ggatcgctcg gcggagtggc
     8881 ccgaaagact cgcgagacga tcgtgctgtg cgaggccgcg ggattcgacg tcatcttcat
     8941 cgaaacggtg ggcgtcggac agtcggaaac cgccgtgcac tcgatggtgg acctcttcat
     9001 gctgttgcag atttccggtg cgggagacga actgcaaggc atcaagcgcg gcatcatgga
     9061 gatggccgac ctgatggtca tcaccaaggc cgacggagag aacatacaca aggccgaact
     9121 ggcacagacc cagttccagg gggccttgcg gcttttcccc gtgcccgaat cgggatggcg
     9181 gcccaaggtc tacacctcgt cggcggtggc ccggacgggg ctggaggagg tctggaaagg
     9241 cgtggaggag tacctcgacc acattcagaa aaacggctat ttccagcaca accgcaaccg
     9301 gcagaacaaa tactggatgt acgagtcgat caacgaggcg ctgcgcggaa gtttctaccg
     9361 cgacccggcc gtggaggcgt gcatcggagc gtacgagaaa cgcgtgctgg aggacaaaat
     9421 ctcgtcgttc atcgccgcca aggagttgct ggagatctat ttcaaggacg cccggacgct
     9481 ggaatgaccc gtgtcacagt ccggcgggcg ggttgccggc aggtggatat gcccataata
     9541 cagcccttat aatcgttaaa atttcgagcc atgaaacaag gacgctttta cctggctgcg
     9601 gcgatattgc tgctcgcttc aggttgtgaa aaagaggacg gagagaacac aggcgactct
     9661 aaatggacac acccgctgac aacgaccctt cacagaaccg atcccggagg agagcagagt
     9721 acatatgtga taacgtacac ctacgacgca aaagatcggc tgaccggaac ccggaactcg
     9781 agagacggcg ttacggaaac gacaacttcg gactacgtat atgacggcaa aacggtgaca
     9841 tacacggaaa aaacatgggc cggtgaaacc ctgtggaatt cgcaaaaatt caaacgcact
     9901 tatctggatg acgctctcga aaaggttttg gaagaacgga taacggacaa ggacgaccat
     9961 atcatccaac ggatttgcaa cgaatacgac cagcaggaac ggctggtcca cagtttggaa
    10021 tattccagag ggaatagtaa agtatccgaa acaaaataca cctacgacgg aaaattggta
    10081 atctgtgaca aatattggct caagaataca ggcgaagtat cggctgtaag caaatacata
    10141 atcacatact ccgacgatga actgacgaaa ccgcttattc acggctgtct ggctgccgaa
    10201 gaaacggccg aacgcccatg ggattgggta agacattaca gttacgatta ccggggacgc
    10261 ctcaacggaa ttacgtacga agcggaaggt aagctcgtct gggagacccg caactacgta
    10321 tatgggaaca aatccctcac ttgcgaaaat cgggaggtgc attatggcac ggatattata
    10381 accatatctg aaacaaccta caaacactga caccgatctc cggcaaaaca gccccgccct
    10441 ccgcgggaga gggcggggat tttcatgcag gaacggccgc aggcacaccg accggaccga
    10501 agccgacagc attacataac cgcatcgtta cacggaacgg acagacgtgc aaccgcgtaa
    10561 tgggtcgcag agcgcgacca gacgaggcgg tgcgaaacgg gccggagatg gagtgagccg
    10621 gatcggaata tgagtgaatc cgagcaagag ccaaccggaa ccgcagcgtg cggccgggaa
    10681 aagccggaaa cggaaagcga aagacagagg gagggccgaa agcgggaaaa cgagaacgga
    10741 gagcaaaccg ggatgggccg gaagcgggga accgccggga agggcggatc aggcttttcc
    10801 gggcaaaagc gattcggacc gcccttccgc acaggccgcg cgcaggcggt cggccagttc
    10861 gggaactccc tcggcggcac gtttgcggat cacttccagc ggattgcgca cgccgcgaat
    10921 cgccggccgt cccgggtcga ccacgtaaac cggaatgtcg ggacgcacgc agcgcaccag
    10981 cgacgccgca ggatagaccg ccagcgacgt tccgaccacc atcaggatgt cggccccggc
    11041 ggcaagttcc gccgcacggt cgaattcggg aaccggctcg ccgaagaaga cgatgtgcgg
    11101 acgcagcagc gaaccgtcgg gagcgcggtc gtcgaaaccc tgctcgacgc cgtcgaacgg
    11161 caggatgagc gacggatcgt ccgtcgaacg aagtttggta agttccccgt gcaggtgaag
    11221 aatatgcgtc gaacccgccc tttcgtgcag attgtcgaca ttctgggtga tgacccggac
    11281 gtcgaaatcg cgttccagac cggcaatcgc ccggtgggcg gcgttcggct cggccttgag
    11341 catttcggca cgccgctcgt tgtagaaacg gatgacgccc cgacggttga aatcaagcgc
    11401 ttcgggaatg cagacctcct cgatccggta attcccccat gttccgtcgg agtcgcggaa
    11461 cgtcgccaaa ccgctgtcgg cgctgacgcc ggcgccggtg aagacaacaa gttttttcat
    11521 tgcatgatgt agtttcgccc ggtaaaggta acaaatttat ggcatagttc gtgcaagatc
    11581 ggtccgatgt aaaccaaata aatattttta cgctatggat caacagaaac acaccaccga
    11641 agacaccctg accgacattt tcggctcgaa agagatgcgt tcgcccgctc ccacggaatt
    11701 cattcccaag aacaagacag cacccgaaat cgcctatcag ctggtcaagg acgagaccta
    11761 tccccagacc cagccgaggc tcaacctggc gacgttcgtg accacctaca tggacgacta
    11821 cgccacacgg ctgatgaacg aagccatcaa catcaactac atcgacgaga cggagtatcc
    11881 gcgcgtcgcg gtgatgtgcg gccgctgcct caatatcgtg gccaacatgt ggaactcgcc
    11941 cgaaaaggcc gagtggaaaa ccggcgcgct gggcatcgga tcgtccgaag catgcatgct
    12001 gggcggagtg gccgcatggc tgcgctggcg ggcgcgccgc aaggccgcag gcaaaccctt
    12061 cgacaaaccc aacctggtga tgagcaccgg attccaggtc gtgtgggaga agttctgcca
    12121 gctgtggcag atcgagatgc gcaccgtgcc cctgacgctc gaccacccga cgctcgacat
    12181 cggcgaggcg ctgaaggcct gcgacgagaa caccatctgc atcgtgccca tcgccggcgt
    12241 gacatggacg ggtctcgacg acgacatcga gggtctcgac aaggcgctcg acgcctacaa
    12301 cgccaagacg ggctacgaaa tcccgatcca cgtcgacgcg gcttccggag gtttcatcct
    12361 gccgttccta caccccgaga agaagtggga cttccgcctc aaatgggtgc tgtcgatctc
    12421 cacgtcgggc cacaagtacg gactggtgta ccccggactg ggatgggtcg tatggaagga
    12481 caagaagtac ctgcccgacg aaatgtcgtt ctcggtcaac tacctcggcg cgaacatcac
    12541 gcaggtgggc ctgaacttct cgcggccggc ggcgcagatt ctcggccagt actacaactt
    12601 catccggctg ggattcgagg ggtacaagga ggtgcagcag aactcgatgg acatcgccaa
    12661 atactgccac gagcagatcg gcaagatgcc gtgcttccgg aactacgcca aagaggtcgt
    12721 caacccgctg ttcatctgga tgatggaccc cgaatacgac aagaaggcca aatggacgct
    12781 gttcgacctg caggccgcct tgcagcagag cggctggatg gtcccggcat acaccatgcc
    12841 caagaacatc gacgagatga tcgtcatgcg catcgtggtt cgccagggca tgtcgcgcga
    12901 catggccgac atgcttctgg gagacatccg caacgccgtg gccgagttcg agaaactccg
    12961 gtaccccacg ccctcgcgca tcaagtacga gaacaaggag caccagaaag gcaaggtcta
    13021 cacgcattga tgcggccgga gatcaccgga cctccgactg ccggaacgct ggcgggaaaa
    13081 gcggccttcg gaccgcaatt tcggccatag catccaaaag aggcttctca agccgcccct
    13141 gaagggcgct ttctcgcggc cggcaacggc tgaccgaaca ttcagggacc ttccccgcga
    13201 cacgcgcccc ctccgggcgg cagaacgccg gacggctcac gcttcacccc cgaagcggag
    13261 ccgtcttttt cgtttgcggc gggaggcnnn nnnnnnngag gctcttccgg accttcggcg
    13321 gcggcctacg caagcccggc gctgccgcca cggaccggaa aaacgccccc gcagcgacac
    13381 gacgcaacga acaaaacata gggcgcaaag gacttgccgg gaccggaaaa aatacgtatc
    13441 tttcgtgcgt tttatcccca acgtctatga aagagaattt cgacattttc ctgatcgtca
    13501 tggcccttct ggccgccgtg gtctacgccg cgctgcactt cttcgaggcg ggttacggct
    13561 atctcttcga ccgccgctac ggacctcccg tgcccaaccg cgtgggctgg atggtgatgg
    13621 aatctccggt tttcatcctc atgtgcgtgc tgtgggcctc gtccgaaagg atgtggcagg
    13681 ccgggccgct ggcgctgttc tgcctgttcc aggcccacta cctccagcgg gccttcatct
    13741 tcccgctgct gatccgcggc aagggccgca tgcccctcgg catcgtcgtg atgggcatgg
    13801 tcttcaacac gctcaacgcc ctgatgcagg gaggctggat tttctacgtc tcgcccgctg
    13861 actactacgc cggatggttc gcacagccct atatctatat cggcggggcg ttgttcgtgg
    13921 ccggaatggc cgtaaacctc cattcggacc acatcatccg ccacctccgc cgcccgggcg
    13981 acacgcgcca ctacatcccc cgcgggggca tgttccgcta cgtctcgtcg gccaactact
    14041 tcggcgaact gctcgaatgg gtgggattcg ccgtagcctc gtggtcgtgg gccggaacgg
    14101 tcttcgcatg gtggaccttc gccaacctcg cac
//
