LOCUS       c00067_gnlPro..        14011 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|FHMINLCA_67.
ACCESSION   c00067_gnlPro..
VERSION     c00067_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 01:15:54
            Original ID  :: gnl|Prokka|FHMINLCA_67
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14011
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14011
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[6972:11772]"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [PFOR_II, POR, POR_N]) and
                     (minimum(2, [ACD1_car, ACP_syn_III_C, AcetylCoA_hyd_C,
                     AcetylCoA_hydro, Acyl-CoA_dh_1, Acyl-CoA_dh_2,
                     Butyrate_kinase, CT_Propionyl_CoA1, CT_Propionyl_CoA2,
                     CT_Propionyl_CoA3, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_2_CAF,
                     CoA_trans_6_Glutaconate, E1_dh, ECH_1, ECH_2, HBT, HBT_2,
                     HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C, Thiolase_N,
                     adh_short, adh_short_C2]) or FA_synthesis) and not
                     (Gly_radical_scatole or Gly_radical or Gly_430_pcre or
                     Gly_8-9_TMA))"
                     /neighbourhood="10000"
                     /product="OD_fatty_acids"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      6973..11772
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [PFOR_II, POR, POR_N]) and
                     (minimum(2, [ACD1_car, ACP_syn_III_C, AcetylCoA_hyd_C,
                     AcetylCoA_hydro, Acyl-CoA_dh_1, Acyl-CoA_dh_2,
                     Butyrate_kinase, CT_Propionyl_CoA1, CT_Propionyl_CoA2,
                     CT_Propionyl_CoA3, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_2_CAF,
                     CoA_trans_6_Glutaconate, E1_dh, ECH_1, ECH_2, HBT, HBT_2,
                     HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C, Thiolase_N,
                     adh_short, adh_short_C2]) or FA_synthesis) and not
                     (Gly_radical_scatole or Gly_radical or Gly_430_pcre or
                     Gly_8-9_TMA))"
                     /neighbourhood="10000"
                     /product="OD_fatty_acids"
                     /protocluster_number="1"
     cand_cluster    1..14011
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(1, [PFOR_II, POR, POR_N]) and
                     (minimum(2, [ACD1_car, ACP_syn_III_C, AcetylCoA_hyd_C,
                     AcetylCoA_hydro, Acyl-CoA_dh_1, Acyl-CoA_dh_2,
                     Butyrate_kinase, CT_Propionyl_CoA1, CT_Propionyl_CoA2,
                     CT_Propionyl_CoA3, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_2_CAF,
                     CoA_trans_6_Glutaconate, E1_dh, ECH_1, ECH_2, HBT, HBT_2,
                     HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C, Thiolase_N,
                     adh_short, adh_short_C2]) or FA_synthesis) and not
                     (Gly_radical_scatole or Gly_radical or Gly_430_pcre or
                     Gly_8-9_TMA))"
                     /kind="single"
                     /product="OD_fatty_acids"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14011
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="OD_fatty_acids"
                     /region_number="1"
                     /rules="(minimum(1, [PFOR_II, POR, POR_N]) and (minimum(2,
                     [ACD1_car, ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (Gly_radical_scatole or Gly_radical or Gly_430_pcre or
                     Gly_8-9_TMA))"
                     /tool="gutsmash"
     CDS             2..1309
                     /locus_tag="ctg67_1"
                     /transl_table=11
                     /translation="PEDAAGPDSLARWEVPDSLLGVSVPDSLAVPAVDPLDTLVGDARK
                     AYLKEQAAKLKAAQKAAAAKARKEKLEEIAKKRQDKTTAKLLAQKEREERRLAARKLKA
                     ESKLRARQARAARKGKVIPVDSTALREIDSLIARNDREMDSLLLQMADSLAADSLAMRI
                     PADSVDSLTDSADSVYRLMKGFRNVRIFRSDFQAVCDSMTAISTDSTIHLYINPVLWNQ
                     GNQITSDVMDIFTENQQITRAEFIGTPMMVSQLDTVHYNQVAGKQMTAWFRDNQIYRND
                     VNGNAQTIYYMQDGEPPQITGMGVIESGDCSFYIEDKQVVTIVYRKDPDWNIYPMDKIP
                     ADQELYLKGFKWEGARRPTQGAVFDRRVRPSQREEKRHLAHPDFPLLKALEERKKQLIE
                     ERRWADRNDQVDAATVEWMRALGFEVGQPRDSGPKL"
     CDS             1399..2556
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MFS_1"
                     /gene_functions="transport (smcogs) SMCOG1058:Major
                     facilitator family (Score: 117.6; E-value: 2e-36)"
                     /gene_kind="transport"
                     /locus_tag="ctg67_2"
                     /sec_met_domain="MFS_1 (E-value: 4.5e-37, bitscore: 117.6,
                     seeds: 192, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKSLIALAFGTLALGMAEFVMMGILPDIARSLGVSIPEAGHLIS
                     AYALGVCFGAPLTVLVARTRPLKHILLALTGLIILGNACAALSPNYWTLLAMRFVSGLP
                     HGAFFGVGSIVAERVADKGRRAEAVSIMVVGMTVANLFGVPLGTYISGVVTWRATFGIV
                     AVWGAVAMLLVKLWVPALPALPDTGMKGQFRFLKSAAPWLVLASVMLGNGGIFCWYSYV
                     SPLMVHTSGFRSEDLTLIVMLAGFGMFAGNIVGGHYADRFTPERVVRFTLGTACLALVG
                     IFFGAHVRYLSLALMCLTTACLFCVSSPQQLLILENSRGGEMLGAALVQVAFNLGNALG
                     AYVGGLPIGHGLGYEYTAIPGAAFVLLGMTAAMIYIRKYPRHEQR"
     CDS             2543..3043
                     /locus_tag="ctg67_3"
                     /transl_table=11
                     /translation="MNSDNSEEIFPVVDAAGNVVGKATRGECHGGSMLLHPVVHLHVFN
                     SRGELYLQKRPAWKDIQPGRWDTAVGGHVDYGETIAEALRREVREELGITDFVPGAVAV
                     YPFRSEREYELVHVFRTVYDGEVRPSGELDGGRFWSPDEIRENLGQGVFTPNFEGEAGL
                     ILG"
     CDS             3125..4570
                     /locus_tag="ctg67_4"
                     /transl_table=11
                     /translation="MQTLLKRWTHALLEWLGLTSATGDALDRWAAFVLVVLAAVVFDLL
                     LQLGIVHGVRKLVERTRAKWDDTLFSVPVLRRMCHILSAILLAVVLPVVFEEKSTGRVI
                     VLRFMEAYIVFSVFRFVNALLYAAFHIAAARPAWQNKPIKGLRQTAQGIALLICTILIV
                     SILLDKSPAILLTGLGASAAVLMLIFRDSILGFVSGIQLAANDMLKVGDWISIPKYGAD
                     GNVEEVSLTTVKIRNWDNTLVMLPPYLLTTDSFTNWHAMQLSGGRRVMRSVAIDMTSVR
                     FCTPEMLDHYRTIDLIRDYVDQTERRVEEYNAAHGIGSGERRINGLHQTNLGVFRAYLV
                     RYLRNEVPVNKDMTLMVRQLQPTETGLPMQLYFFTDTVVWVDYEGIQSDVFDHVLAVIP
                     EFGLRVFQNPSGEDVASLRNAFFPNAQTPSQTPPQASPQASSQAAPQNAPPLHASRPAA
                     PQRLQAEQPAPEEAKAPASASPE"
     CDS             complement(4539..6200)
                     /locus_tag="ctg67_5"
                     /transl_table=11
                     /translation="MEWLKELFVEHSALQAVVVVSLISTIGIGLGKIRFFGISLGTAFI
                     FFVGILAGHFGLSLDPAMLTYAESFGLVIFVYALGLQVGPGFFSSMRADGLRLVSPAIA
                     IVLLGTALAMAMSYAFGVSMPDMSGILCGATTNTPALGAAQQTLQQMGIDANGAALSCA
                     VAYPLGVVGVILAVVFLRKLFVRPCDMPGPDAEHRKNVFIASYHLTNPAVFGKSVHEIA
                     TQSHHHFVISRLWRDGRVSIPTSDKTLQENDLILVITTPGEADALRLIFGEQETKDWNT
                     ENIDWNSVDSQLISQRILVTRPEINGKKLSQLRLRNTYGINISRVYRSGVQLLATPDLR
                     LQLGDRLTVVGEAEAIRNVEKILGNAVKSLNEPNLAAVFIGLILGLTLGSIPVAIPGIS
                     IPVKLGLAGGPIIVGILIGTFGPRLHMITYTTQSANLMLRALGLSMYLACLGLDAGTHF
                     FETVMRPEGALWLGIGFALTFVPVVLVGLFALRVLKVDFGSVSGLLCGSMANPMALNYV
                     NDTIEGDNPSVSYATVYPVCMFLRVIIIQVMLMLVL"
     CDS             complement(6554..6859)
                     /locus_tag="ctg67_6"
                     /transl_table=11
                     /translation="MRPGNREPPPRSGCGPKARNTRWPSGTQMRHNSREYAGVSLDNPI
                     FNRRAARNDISKAQLAVRSQQLAVTQTVQAKYEFVFRRRFPISTAGSRCNSENGRF"
     CDS             complement(6973..8268)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     OD_fatty_acids: AcetylCoA_hydro"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     OD_fatty_acids: AcetylCoA_hyd_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg67_7"
                     /sec_met_domain="AcetylCoA_hyd_C (E-value: 3.9e-63,
                     bitscore: 201.9, seeds: 181, tool: rule-based-clusters)"
                     /sec_met_domain="AcetylCoA_hydro (E-value: 3.6e-21,
                     bitscore: 65.9, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHYTTAAEAVKLIRSNDSVYIQGSTSIPEALVAAMAERGGELEHV
                     TVYSAFAVGAFDAPYCRPEYKESFLVNSLFVANNIRRWLADGYGQTIPAFLGEIPALFR
                     DGTLPLDVALINVSPPDAEGYCSFGVSADLAVSAVECAKTIIAQVNRAMPYSYGDAVIH
                     VSRLAAAVEVDSPLVEVPTAVPSETERKIGSYIAELIPDGATLQIGVGGIPNAVLAALG
                     GHRHLGLHTEAMTDGVLPLLESGVIDNSQKAVMPGVTVASLALGSRRLYDYMDYRKDLV
                     MKDVAWTNDPFRIRQNPKVMAINSAVEVDLTGQVCADSVGMRIISGVGGQHDFMYGGAL
                     SEGGKTFIAIPSTTPKGESKIRALLSPGAGVVTTRHMVQHVVTEYGVAHLRGRNLAERA
                     RALIAVAHPSVREELERAAAERFGYSFLRLKA"
     CDS             complement(8273..9583)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg67_8"
                     /sec_met_domain="Aminotran_1_2 (E-value: 1.3e-21, bitscore:
                     67.0, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIPFDRSCLRSALERMDIADIAQATIRQSGDIARTMERDTGVEF
                     LHLEMGVPGLPPERAGVEAECAALQAGVASQYPNMFGIPELKTQASRFLKAFLDVEVAP
                     RGCIPTVGSMQGSFTTFLLCSQLDPQRRKILFIDPGFPVQRSQVRILGIPSESFDIYDY
                     RGEKLGPKIESVLAAGDVAAIVYSNPNNPAWICLTEDELRTIGELATRYDAIVIEDLAY
                     LCMDFRKPLGRPFEAPYQASVARYTDNYILLVSGSKIFSYAGQRIAVAAISDALFRREY
                     PALRRRYNIGRLGDAYVLVFLYAASSGTSHSAQHALAAMFRAAADGELDFVGEASEYAR
                     RARLTKETFLRHGFRIVYDKDRDEPVSDGFFYTVGYGAMTSAELLSELLLYGICAISLT
                     STGSRQSGIRVCVSQMNRPEQFEMLEERLTAFAENNR"
     CDS             complement(9580..10167)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     OD_fatty_acids: POR"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg67_9"
                     /sec_met_domain="POR (E-value: 3.6e-40, bitscore: 127.8,
                     seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRDIILSGVGGQGILSIAAVIGRAALEDGLHIKQAEVHGMSQRG
                     GDVQSNLRISSSAIRSDLIPRGAADLIVSMEPMEALRYLPWLADDGWVITGITPLINIP
                     NYPEGETLRRELEKLPHAVVLDADAVAKAAMAPRSANMALLGAAAPLLGIDAAKLESGI
                     RAIFARKGGQVVETNLAAFRAGYEATQKQAKP"
     CDS             complement(10174..11772)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     OD_fatty_acids: POR_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg67_10"
                     /sec_met_domain="POR_N (E-value: 1.9e-18, bitscore: 56.9,
                     seeds: 31, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 8.7e-20, bitscore:
                     61.0, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAKRELLLGDEALALGALHAGLSGVYAYPGTPSTEITEYIQQHPL
                     AAQRNVHRTWSSNEKTAMEEALGMSFAGKRALVCMKHVGLNVAADAFVNSAMTGANGGL
                     VVVAADDPSMHSSQNEQDSRFYGKFALVPTFEPADQQEAYDMAKAAFDLSERFRIPVLM
                     RLTTRMAHSRAVVETGEARAENPLSHPEQPRQWVLMPGNSRVRYQTLLEDYARLEEESA
                     ASPFNAYTEGPDKRLGIVACGIAHNYLMENYPDGCPHPVLKIAQYPLPRTLVRRIAAEC
                     GTLLILEEGQPVVEEIVRGVLPNPVAIRGRLTGELPRTGELTPDSVRTALGMAPRRTHA
                     ASGIVVPRPPALCQGCGHRDMYTALTEVIREEYPAGKVFSDIGCYTLGWLAPLHAIDTC
                     VDMGASITMAKGAADAGQHPSVAVIGDSTFTHSGMTGLLDAVNERADITVIISDNLTTG
                     MTGGQDSAGTGRLEQICAGIGVDPAHIRTVEPLPKNREEMKAVIREEIAHRGVSVIIPR
                     RECIQTAKRHNAAKK"
     CDS             12071..12775
                     /locus_tag="ctg67_11"
                     /transl_table=11
                     /translation="MNNSPNIKQVETVLKYIKNELYSGRLQPGERLPAERRLADMLGVG
                     RAHVRAAFQKLEFYGIVQTFPQSGTVVAQEKMQVLERMITDALQIRQYDFASLVYVRVL
                     LEIEAIKLCARNRTAEDLENIERALEECEAKFYTEERVSKDFAYHQALARGAHNPVIAS
                     MLLVITPDVLRYYQRYRVCTVPQEEVYFEHRELLRCVREKDEEGAVAMQRRHLKSLSEF
                     AAAFNDENHFLE"
     CDS             complement(12851..13204)
                     /locus_tag="ctg67_12"
                     /transl_table=11
                     /translation="MDKLCKIRDLQRAVHQFESAFEKRYGICLNEGMTLCSLSKTGRLC
                     PGELGELLGLTPSNTSKVLRSVEQKGLVTRELCNEDRRQMYYSLTQQGRELLASVSCRE
                     VETPEILRDWLCG"
     CDS             complement(13188..13391)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg67_13"
                     /sec_met_domain="Fer4 (E-value: 4.8e-09, bitscore: 25.8,
                     seeds: 528, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 0.00026, bitscore: 11.5,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MALTVDALLCPQNHRCPLIPICPAGAISQEGNSLPRIDPGKCIEC
                     GKCVKRCGMQAVYKAKEHGQTL"
     CDS             complement(13391..13840)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GlcNAc_2-epim"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg67_14"
                     /sec_met_domain="GlcNAc_2-epim (E-value: 7.8e-05, bitscore:
                     11.8, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKLLITAFALLAFAAGSQAQTNNKNAKNMKTIALTKADFLKKVA
                     DYEKNPEEWKYLGDKPALIDFYASWCGPCKALAPVLEELAAEYGDRIYIYKINTEEEQE
                     LAAAFGIRSIPTLLFIPMEGKPQMAQGALPKASLKEAIDKVMLGK"
ORIGIN
        1 gccggaagac gccgcagggc cggattcgct ggcccggtgg gaggtccccg attcactgct
       61 gggcgtttcc gtcccggatt cgctggccgt tccggccgtc gatccgctcg acacgctggt
      121 cggcgatgcc cggaaagcct acctcaagga gcaggccgcc aagttgaagg cggcccaaaa
      181 agccgctgcc gccaaggccc ggaaggaaaa actggaggag atcgccaaaa aacgccagga
      241 taagacgacg gccaaactgc tggcccagaa ggagcgggag gagcggcgtc tcgctgcgcg
      301 caaactcaag gccgagtcga aactccgcgc ccgtcaggcc cgcgccgccc gcaaaggcaa
      361 ggtgattccg gtcgattcca cggccctgcg cgagatcgac tcgctgatcg cccgcaacga
      421 ccgggagatg gattcgctgc tgttgcagat ggccgattcg ctggccgccg actcgctggc
      481 gatgcggatt ccggccgact cggtcgattc gctcaccgac tccgccgact cggtttaccg
      541 cctgatgaag ggtttccgca atgtgcgcat tttccgttcc gatttccagg ccgtatgcga
      601 ctcgatgacg gccatcagca ccgattcgac gatccacctc tacatcaatc ccgtgctgtg
      661 gaaccagggc aaccagatca cctccgacgt gatggacata ttcaccgaga accagcagat
      721 cacgcgcgcc gagttcatcg gcactccgat gatggtctcc cagctcgaca cggtccatta
      781 caaccaggtg gcgggcaagc agatgacggc gtggttccgc gacaatcaga tctaccgcaa
      841 cgacgtgaac ggcaatgccc agacgatcta ctacatgcag gacggcgagc cgccccagat
      901 cacgggcatg ggcgtcatcg agagcggcga ctgttcgttc tatatcgagg acaaacaggt
      961 cgtgacgatc gtctaccgca aggaccccga ctggaacatc tatccgatgg acaagattcc
     1021 cgccgatcag gagctttacc tcaaggggtt caagtgggag ggcgcgcggc gtccgacgca
     1081 gggggcggtt ttcgaccgca gggtccggcc ctcgcagcgc gaggagaaga ggcatctcgc
     1141 acatccggat ttcccgcttc tgaaagccct cgaggagcgc aagaagcagc tgatcgagga
     1201 gcgccgctgg gccgaccgca acgatcaggt cgatgccgcc accgtggagt ggatgcgggc
     1261 gctgggcttc gaggtgggcc agcctcggga ttcgggaccc aagctctgaa aaattggaaa
     1321 aaggtgaaaa gacgcaaaaa cttttcacct tttttgtgct atttttgcag ccggttagcc
     1381 gttaatgtct gttttcccat gaagaaaagt ctgatcgccc tggcattcgg gacgttggcg
     1441 ctcggtatgg cggagttcgt gatgatgggc attctgcccg acatcgcccg cagcctcggc
     1501 gtctcgatcc ccgaagcggg gcacctgatc tccgcctatg cgctgggcgt ctgcttcggg
     1561 gcgcccctca cggtgctggt ggcccgcacg cggccgctga aacacatcct gctggccctc
     1621 acgggcctga tcattctcgg caacgcctgt gcggcgcttt cgccgaacta ctggaccctg
     1681 ctggccatgc gtttcgtctc ggggcttccc cacggggcct tcttcggcgt ggggtcgatc
     1741 gtcgccgagc gcgtcgccga caagggccgg cgggccgagg ccgtgtcgat catggtcgtg
     1801 ggcatgaccg tcgccaacct cttcggcgtg ccgctgggaa cctatatcag cggcgtcgtg
     1861 acgtggcgcg ccacgttcgg gatcgtcgcc gtgtggggag ccgtggccat gctgctcgtg
     1921 aaattgtggg ttccggctct gcccgcgctg cccgatacgg ggatgaaggg gcagttccgg
     1981 tttctgaaaa gcgccgctcc gtggctggtg ctggcgtcgg tgatgctggg caacggcggc
     2041 atcttctgtt ggtacagcta cgtcagcccg ctgatggtcc acacctcggg gttccgttcc
     2101 gaggacctga cgctgatcgt catgctggcc ggtttcggca tgtttgcggg caatatcgtc
     2161 ggcggtcact atgccgaccg gttcacgccc gagcgggttg tgcgtttcac gctcggcacg
     2221 gcctgtctgg cgctcgtcgg catcttcttc ggggcgcatg tccgctatct ttcgctggcg
     2281 ctgatgtgtc tgactacggc ctgcctcttc tgcgtatcgt cgccccagca actgctgatc
     2341 ctcgaaaatt cgcgcggcgg cgagatgctc ggcgcggcgc tcgtgcaggt ggctttcaac
     2401 ctgggcaacg ccctgggggc ctacgtcggc ggcctgccga tcgggcacgg gctcggctat
     2461 gaatatacgg cgattcccgg cgcggctttc gtactgctgg ggatgacggc cgccatgatc
     2521 tacatccgta aatatccccg gcatgaacag cgataacagc gaagagatct ttcccgtggt
     2581 cgacgcggcg gggaacgtcg tcggcaaagc cacgcgcggc gagtgccacg gcgggtcgat
     2641 gctcctgcac ccggtggtgc acctccatgt tttcaattcg cgcggcgaac tctatttgca
     2701 gaaacgcccc gcctggaagg acattcagcc cggacggtgg gacacggccg tgggcggcca
     2761 tgtggactac ggcgagacga tcgccgaagc cctgcggcgc gaggtgcgcg aggagctggg
     2821 catcacggat ttcgtgcccg gggcggttgc ggtctatccg ttccgctcgg aacgcgaata
     2881 cgaactggtc catgtcttcc gcacggtcta cgatggcgag gtccgtccga gcggggagct
     2941 tgacggcggg cgtttctggt ccccggacga aatccgcgaa aacctcggac agggtgtttt
     3001 cacacccaac ttcgaaggcg aggccggatt gattctcggg tgattccgtt gtccgcgccg
     3061 gcgtcgtttc cggtttttcg gccgccgctg cggttgaggc ccgaaagttg atgcgggtac
     3121 gggtatgcag acacttctga aacgttggac gcacgccctg ctcgaatggc tgggcctgac
     3181 ttcggccacc ggcgatgcgc tcgaccgctg ggcggctttc gtgctcgtgg tgctggccgc
     3241 cgtggttttc gacctgctgc tgcaactggg catcgtacac ggggtgcgga aactcgtgga
     3301 gcgcacccgg gccaaatggg acgacacgct tttcagcgtt ccggttctcc ggcgcatgtg
     3361 tcatattttg agcgccattc tgctggccgt cgtgctcccg gtggtcttcg aggagaaatc
     3421 caccgggcgc gtcatcgtcc tgcggttcat ggaggcctat atcgtctttt cggttttccg
     3481 cttcgtcaac gccctgctct atgctgcctt ccacatcgct gcggcgcgtc ccgcctggca
     3541 gaacaaaccc atcaagggcc tgcggcagac ggcgcagggc attgcgctgc tgatctgcac
     3601 gattctgatt gtttcgatcc tgctcgacaa gtcgcccgcc atcctgctga cgggactggg
     3661 cgcctcggcg gccgtgctga tgctgatttt ccgtgacagc atcctcggct tcgtttcggg
     3721 cattcagctc gcggccaacg acatgctcaa ggtcggagac tggatttcga tccccaagta
     3781 cggggccgac ggcaacgtcg aggaggtgtc gctcacgacg gtcaagatcc gcaattggga
     3841 caacacgctc gtcatgctgc cgccctacct gctgacgacc gattcgttca ccaactggca
     3901 cgccatgcag ctttcgggcg ggcggcgcgt gatgcgctcc gtggcgatcg acatgacgag
     3961 cgtgcgtttc tgcacccccg agatgctgga ccactaccgt acgatcgacc tgatccgcga
     4021 ctacgtcgat cagaccgaac gccgcgtcga ggagtacaac gccgcgcacg gcatcggctc
     4081 cggggaacgg cggatcaacg gcctgcatca gaccaacctc ggggttttcc gggcctatct
     4141 ggtccgctac cttcggaacg aggttccggt gaacaaggat atgacgctga tggtgcggca
     4201 gttgcagccc accgaaacgg gacttccgat gcagctctat ttctttaccg atacggtcgt
     4261 gtgggtggat tacgagggga ttcagtcgga tgtcttcgat catgtgctgg ccgtgattcc
     4321 cgaattcggg ttgcgggtct ttcagaatcc gtcgggggag gacgtcgcct cgctgcgcaa
     4381 tgcctttttt ccaaacgcgc agacaccctc gcagacaccc ccgcaggcgt caccgcaggc
     4441 ctcctcacag gccgccccgc aaaatgcgcc gcccctgcat gcatcccggc cggccgcccc
     4501 gcaaaggctg caggcggaac agcccgcccc ggaggaggct aaagcaccag catcagcatc
     4561 acctgaatga tgatcacgcg caggaacatg cacacgggat agaccgtggc gtaggatacg
     4621 gaggggttgt cgccttcgat cgtgtcgttc acgtagttga gcgccatcgg gttggccatg
     4681 ctgccgcata gcagtcccga gaccgatccg aagtcgacct tcagcacccg cagggcgaac
     4741 agccccacca gcaccaccgg cacgaacgtc agggcgaatc cgatgccgag ccacaaggcc
     4801 ccctcggggc gcatgacggt ctcgaagaag tgggttccgg catccagccc gaggcatgcg
     4861 aggtacatcg aaaggcccag cgcgcgcagc atcaggttgg cgctctgggt ggtgtaggtg
     4921 atcatgtgga gccggggacc gaacgtgccg atcaggatgc cgacgatgat cgggccgcct
     4981 gcgagtccca gtttcacggg aatcgaaatc ccggggatcg ccacgggaat gcttcccagc
     5041 gtgaggccga ggatcaggcc gatgaacacc gccgcgaggt tgggttcgtt gaggctcttg
     5101 acggcgttgc cgaggatttt ctcgacgttg cggatcgcct ccgcttcgcc caccacggtc
     5161 agacggtcgc ccagctgcaa acgcaggtcg ggggtggcca gcagctgcac gcccgagcgg
     5221 tacacgcggc tgatgttgat gccgtaggtg ttccgcaggc gcaactgcga gagtttcttg
     5281 ccgttgattt cggggcgtgt cacgaggatg cgctgcgaga tgagctggct gtcgacggag
     5341 ttccagtcga tattttccgt gttccagtcc ttggtctcct gctcgccgaa gatcagccgc
     5401 agggcgtcgg cctcgccggg cgtggtgatg accaggatca ggtcgttctc ctgtagggtc
     5461 ttgtccgagg tggggatcga aacccgcccg tcgcgccaca ggcgcgaaat gacgaaatgg
     5521 tggtggctct gcgtcgcgat ttcgtggacg ctcttgccga agaccgcggg attggtgagg
     5581 tggtagctgg cgatgaagac gttcttgcgg tgttcggcgt cgggtcccgg catgtcgcag
     5641 ggacgcacga agagcttgcg caggaagacc acggccagaa ttacgcctac gacgcccagc
     5701 gggtaggcca cggcgcagct caacgccgct ccgttggcgt cgatgcccat ttgttgcagt
     5761 gtctgctgcg cggcgcccag cgccggggtg ttggtcgtcg cgccgcacag aatgcccgac
     5821 atgtcgggca tcgagactcc gaaggcgtag ctcatcgcca tggccagggc cgttccgagc
     5881 agcacgatgg cgatggcggg cgagacgagc cgcagtccgt cggcgcgcat cgaactgaag
     5941 aagcccggcc ccacctgaag gccgagggcg tagacgaaga tcaccagtcc gaaactctcg
     6001 gcataggtca gcatcgccgg gtcgagcgaa agcccgaaat gcccggccag aatgcccacg
     6061 aagaagatga aggccgttcc gagcgagatt ccgaaaaagc ggatctttcc cagtccgata
     6121 ccgatcgtcg agatgagcga aaccaccacg acggcctgca aagccgagtg ctcgacgaac
     6181 aattctttaa gccattccat tccttcaact gttgaaaccg ttgcaaaagt aggtcaaatt
     6241 ttccggattg ccgctttttt gcagaacgaa aagtggtccg tatgcgtccg ggcgtattat
     6301 tttgcctttt cggggtatga cattttggtc gagccttatt acaaaaacgc tctgcctatt
     6361 gtgggttggg ataatttgtc tacttttgta ttgctgggat aaacacagat catcagtgac
     6421 gcacgaagga cttttctgcc ggagaaggtc cgggattcaa tccggcagcc gcccggatta
     6481 ttcaggaact tgatgttccg ggtagcagcg agggtgaccg ttttaggtca ccctttttgt
     6541 ttgaattcgt ttatcagaat ctcccgtttt cagagttgca acggcttccc gcggtggaaa
     6601 tcgggaatct tcgacggaaa acgaactcgt atttggcctg cacggtttgg gtgacggcga
     6661 gctgctggct gcgcacggcg agctgcgcct tgctgatgtc gttgcgcgcg gcccggcggt
     6721 tgaagatcgg gttgtcgagc gagacgccgg cgtattcgcg gctgttatgg cgcatctgtg
     6781 tcccggacgg ccaccgcgtg ttccgagcct tcgggccgca gccgcttcgc gggggcggtt
     6841 cccggttccc cgggcgcatg acggatcacg ccggtcgtgc ggcggccgtc gggggcgaaa
     6901 aagaggtgat tgcggaatat ctgcctatcg gtaaaaaggc ccgcccggtc ttttcgggga
     6961 ccgggcgggg gtttatgctt tgaggcgcag gaacgaatag ccgaagcgtt cggctgcggc
     7021 gcgttccagc tcctcgcgga ccgaggggtg cgccacggct atcagcgccc gggcgcgttc
     7081 ggcgaggttg cggccccgca ggtgcgccac gccgtattcg gtgacgacgt gctggaccat
     7141 gtggcgcgtc gtgacgacgc ccgcgccggg cgacagcagc gccctgatct tcgattcgcc
     7201 cttgggcgtg gtcgagggga tggcgatgaa ggtcttgccg ccttcggaca gcgccccgcc
     7261 gtacatgaaa tcgtgctggc cgcccacgcc cgagatgatg cgcattccga ccgagtcggc
     7321 gcacacctgc cccgtgaggt ccacctccac ggccgaattg atggccatga ccttcgggtt
     7381 ttgccggatg cggaacgggt cgttggtcca tgccacgtcc ttcatcacga ggtctttgcg
     7441 gtagtccatg tagtcgtaca gccggcgcga gccgagggcc agcgaggcca ccgtcacgcc
     7501 gggcatcacc gccttctgcg agttgtcgat cacgccgctt tccagcagcg gcagcacgcc
     7561 gtcggtcatc gcctcggtgt gcagtcccag atgccggtgg ccgccgaggg ccgccagtac
     7621 ggcgttcgga atgccgccca cgccgatctg caacgtcgcc ccgtcgggaa tcagttcggc
     7681 gatgtagctg ccgattttcc gttccgtttc gctcggcacg gccgtcggga cctccaccag
     7741 cggggagtcg acctccacgg ccgccgccag gcgcgagacg tggatcacgg cgtcgccgta
     7801 ggagtagggc atcgcccggt tgacctgcgc gatgatggtc ttggcgcact ccacggcgga
     7861 aaccgccaga tcggccgaga cgccgaacga gcagtagcct tcggcgtcgg gcggcgagac
     7921 gttgatgagt gcgacgtcga gaggcagcgt gccgtcgcgg aacagcgcgg ggatttcgcc
     7981 caggaaggcc ggaatggtct gtccgtagcc gtcggccagc cacctgcgga tgttgttggc
     8041 gacgaacagg ctgttgacga ggaacgactc cttgtattcg gggcggcagt agggggcgtc
     8101 gaaggctccc acggcgaagg ccgaatagac cgtcacatgc tccagttcgc cgccccgttc
     8161 ggccattgcg gccacgagcg cttcggggat cgaggtgctg ccctgaatgt agacgctgtc
     8221 gttggatcgg atgagtttta ccgcctccgc ggcagtcgtg tagtgcatgt tgtcagcggt
     8281 tattttctgc aaaagcggtt aaacgttctt cgagcatttc gaactgttcg gggcggttca
     8341 tctgcgagac gcagacgcgg atgccgctct ggcggctgcc ggtcgaggtg agcgagatgg
     8401 cgcagatgcc gtagagcagc agctcgctca acagttcggc gctggtcatc gcgccgtagc
     8461 cgaccgtgta gaagaatccg tcgctgaccg gctcgtcgcg gtccttgtcg tagacgatgc
     8521 ggaatccgtg gcggaggaac gtctccttgg tcagccgggc gcgccgggcg tactccgagg
     8581 cttcgcccac gaagtccagt tcgccgtcgg ccgccgcgcg gaacattgcc gccagggcgt
     8641 gctgcgccga atggctcgtg ccggatgagg ccgcatagag aaagaccagt acgtaggcgt
     8701 cgcccagccg tccgatgttg taacgccggc gcagggcggg gtactcgcgg cggaaaagcg
     8761 catcggagat cgccgccacg gcgattcgct gtccggcgta gctgaatatc ttcgacccgg
     8821 agaccagcag gatgtaattg tccgtgtagc gggccaccga agcctggtag ggggcttcga
     8881 aaggccgtcc cagcggtttg cggaaatcca tgcagaggta ggcgaggtcc tcgatgacga
     8941 tggcgtcgta ccgcgtggcc agctcgccga tcgtgcgcag ctcgtcctcc gtgaggcaga
     9001 tccacgccgg gttgttgggg ttcgagtaga cgatggccgc cacgtcgcct gcggcgagga
     9061 cgctctcgat cttcggcccc agcttttcgc ccctgtaatc gtagatgtcg aacgactccg
     9121 agggaatgcc gagaatgcgt acctgactgc gctgcacggg gaatccgggg tcgatgaaga
     9181 ggattttgcg ccgctgcggg tcgagctgcg agcagagcag gaatgtggtg aagctgccct
     9241 gcatcgaccc gacggtgggg atgcagcccc ggggggccac ctccacgtcg aggaaggctt
     9301 tcaggaagcg cgacgcctgc gtcttgagtt ccggaatgcc gaacatgttg ggatactgcg
     9361 acgcgacgcc cgcctgcagg gccgcgcatt cggcctcgac gcccgcccgt tcgggcggca
     9421 gccccggcac gcccatttcg aggtggagga actccacgcc cgtgtcgcgc tccatcgtgc
     9481 gggcgatgtc gcccgactgg cggatcgtgg cctgcgcgat gtcggctatg tccatccgct
     9541 ccagcgcgga gcgcaggcag gacctgtcga acggtatttt catggctttg cctgtttttg
     9601 ggtcgcttcg tagccggcgc ggaacgccgc gagattcgtt tcgacgacct gcccgccctt
     9661 gcgggcgaag atggcgcgga tgccggactc cagtttcgcg gcgtcgattc cgagcagcgg
     9721 cgcggcggct cccagcagcg ccatgttggc cgagcggggc gccatggcgg ctttggcgac
     9781 ggcgtcggcg tcgaggacta cggcgtgcgg gagtttttcc agttcgcgcc gcagggtctc
     9841 gccctccggg tagttcggga tgttgatcag cggcgtgatg ccggtgatta cccatccgtc
     9901 gtcggcgagc cacggcaggt agcgcagcgc ctccatcggc tccatcgaga cgatgagatc
     9961 ggccgcgccg cgcgggatga gatccgaacg gatggccgac gacgagatgc gcaggttcga
    10021 ctgcacgtcg ccgccgcgct ggctcatgcc gtggacctcg gcctgcttga tgtgaagccc
    10081 gtcttcgagg gcggcccgtc cgatgacggc ggcgatcgag aggattccct ggcctcctac
    10141 gcccgagagt atgatgtcgc gtttcataag cctttacttt ttagcagcgt tgtgtcgctt
    10201 tgcggtctgg atacattctc ttcgcgggat gatcaccgag acgccccggt gggcgatctc
    10261 ctcgcggatc acggccttca tctcctcgcg gttcttgggc aggggctcga ccgtgcggat
    10321 atgtgcggga tcgacgccga tgccggcgca gatctgttcc agacggcccg ttccggccga
    10381 atcctgcccg ccggtcatgc ccgtcgtgag gttgtccgag atgatgaccg tgatgtccgc
    10441 gcgctcgttc acggcgtcca gcaggcccgt catgcccgaa tgggtgaagg tcgagtcgcc
    10501 gatcacggcc accgaagggt gctggcccgc gtcggccgcg cctttggcca tggtgatcga
    10561 ggcccccatg tcgacgcatg tgtcgatggc gtgcagcggc gccagccacc ccagcgtgta
    10621 gcagccgatg tcgctgaaaa ccttgcccgc ggggtattcc tcgcggatca cctccgtcag
    10681 ggctgtgtac atgtcgcggt gtccgcatcc ctggcagagc gcgggcgggc ggggtacgac
    10741 gattccgctt gcggcgtgcg tccggcgggg cgccatgccg agggccgtgc gcacgctgtc
    10801 gggcgtcagc tccccggtgc ggggcagttc gccggtcagg cgtccgcgga tcgccacggg
    10861 attgggcagc acgccccgga cgatctcttc cacgacgggc tggccctctt cgaggatcag
    10921 cagcgtgccg cactcggcgg cgatacggcg caccagcgtg cggggcagcg ggtactgcgc
    10981 gattttcagc accgggtgcg gacatccgtc ggggtagttc tccatcaggt agttgtgtgc
    11041 gatgccgcag gcgacgatgc ccagccgttt gtccggaccc tccgtatagg cgttgaacgg
    11101 gctggcggcg gactcctctt ccagccgggc gtaatcctcc agcagcgtct ggtatcgcac
    11161 gcgcgagttt cccggcatca gcacccactg gcggggctgt tcgggatggc tcaacgggtt
    11221 ttcggcgcgc gcctcgcccg tctcgacgac ggcccgcgaa tgggccatgc gggtcgtcag
    11281 gcgcatcagc accggaatcc ggaaccgttc cgagaggtcg aaggcggcct tcgccatgtc
    11341 gtatgcctcc tgctggtccg caggctcgaa ggtcggcacg agggcgaatt tcccgtagaa
    11401 gcgcgaatcc tgttcgttct gcgacgagtg catcgagggg tcgtcggctg ccacgaccac
    11461 cagcccgccg ttggctccgg tcatcgccga gttgacgaag gcgtcggctg ccacgttcag
    11521 ccccacgtgt ttcatgcaga ccagcgcgcg cttgccggcg aacgacatgc cgagcgcctc
    11581 ctccatggcc gtcttttcgt tcgacgacca cgtgcggtgc acgttgcgct gcgcagccag
    11641 gggatgctgc tggatgtatt ccgtgatttc ggtcgagggt gtgcccggat aggcatagac
    11701 acccgacagt cccgcgtgga gcgcccccag tgcgagggct tcgtctccga gtaagagttc
    11761 tcgttttgcc atgagcttac ggtctggttc actttttaca aatttaggaa aatttaatta
    11821 aaatccaata tttggcgata atttatcaga cattcggctg gaatcgggaa aaaatatagg
    11881 tttcaacccg gtttctggtt gaaaaatgta aaatgcgctc cgggacgccg tgcggcccgt
    11941 atccggcctt tcggcttttc ccggaggcgg ggactttgcg gagcggaatc tgcgggacgt
    12001 tcacgaaatt gccggaattg tttggtttga ttggtttttt tgcgatcttt gtgctgcaaa
    12061 agaataaccc atgaacaact cgccgaacat caaacaggtg gaaaccgtcc tgaaatacat
    12121 caagaatgag ctttattccg gacgtttgca gccgggcgaa cgcctcccgg ccgagcggcg
    12181 gctggccgac atgttgggcg tcggccgcgc ccatgtgcgt gcggcgtttc agaaactcga
    12241 attttacggc atcgtccaga ccttccccca gagcggcacg gtggtcgccc aggagaagat
    12301 gcaggtgctc gaacgcatga tcaccgacgc gcttcagatc agacagtacg acttcgcgtc
    12361 gctggtctac gtgcgtgtgc tgctcgaaat cgaggccatc aagctctgcg cccgcaaccg
    12421 tacggcggag gatctggaga acatcgaacg ggcgctggag gagtgcgagg cgaaattcta
    12481 taccgaggag cgtgtctcga aggacttcgc ctaccaccag gcgctggccc gcggggcgca
    12541 caatccggtg atcgcgtcga tgctgctggt catcacgccc gacgtgctgc gttattacca
    12601 gcgttaccgt gtctgcacgg ttccgcagga ggaggtctat ttcgagcatc gcgaattgct
    12661 gcgctgcgtc cgcgagaagg acgaggaggg ggccgtcgcg atgcagcgcc gccacctcaa
    12721 gtcgttgagc gaattcgctg cggccttcaa cgacgagaac cattttctcg aatagcgctc
    12781 ctgccgtccc gaaacgacaa acggctgtcc cttcggggac agccgttgct gtgtttggtt
    12841 gcgtcacgtg ctacccgcag agccagtcgc gcaggatttc gggtgtttcc acctcccggc
    12901 agctgaccga agcgagcagt tcgcgtcctt gttgcgtgag tgagtagtac atctggcgcc
    12961 ggtcctcgtt gcagagttcg cgggtcacca gtcctttctg ttccaccgag cggagcactt
    13021 tcgaggtgtt cgacggcgtg agtcccagca gttcccccag ctctcccggg cagagacgcc
    13081 cggttttcga gaggctgcac agcgtcatgc cctcgttcag gcagatgccg tagcgttttt
    13141 cgaacgcgct ttcgaactgg tgcacggcgc gctgaaggtc gcggatctta caaagtttgt
    13201 ccatgttcct tcgctttata taccgcctgc atgccgcagc gtttcacgca tttgccgcat
    13261 tcgatgcatt ttccggggtc gatccgcgga agggagttcc cctcctgcga gatcgcgccc
    13321 gcggggcaga tcgggatcag cgggcaacgg tggttctgcg ggcatagcag ggcgtcgacc
    13381 gtcagtgcca ttatttaccc agcatcactt tgtcgatggc ctccttgagc gaagccttgg
    13441 gcagggcgcc ctgggccatc tggggtttgc cttccatcgg gatgaacagc agcgtgggga
    13501 tcgagcggat gccgaacgcc gcggcaagct cctgctcctc ctcggtgttg atcttgtaga
    13561 tgtagatccg gtccccgtat tcggcggcca gttcttcgag caccggtgcg agggccttgc
    13621 agggaccgca ccacgaggcg tagaagtcga tcagggcggg tttgtcaccg aggtatttcc
    13681 actcctcggg atttttttca tagtcggcga ccttcttcag aaagtcggct ttggtcaatg
    13741 cgatcgtttt catattcttt gcgtttttgt tgtttgtctg tgcctggctt ccggcggcga
    13801 aggccagcag cgcgaaagcg gttatgagca gttttttcat cttgtttttt attgttctct
    13861 atcaataacg atgcaaagat agattttatt ttccgataaa acaaatttcc aatggaaaat
    13921 attgtgatct gatgattcac tgatttgaaa acggcgggtt tcgcccgcgg gaattttatg
    13981 tacttttgat gtcaaccgac gcacgcagca c
//
