LOCUS       gnlProkkaIIKKHECN_11   14141 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|IIKKHECN_11.
ACCESSION   gnlProkkaIIKKHECN_11
VERSION     gnlProkkaIIKKHECN_11
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-01 15:47:37
            Original ID  :: gnl|Prokka|IIKKHECN_11
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 34045
            Orig. end    :: 48186
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14141
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[10000:10258]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10258
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..14141
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..14141
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="2"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             complement(542..1771)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1045:glycosyl transferase group 1 (Score: 99.9;
                     E-value: 3e-30)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg11_32"
                     /sec_met_domain="Glycos_transf_1 (E-value: 2.7e-25,
                     bitscore: 80.4, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKKILFVINTLSRAGAETALLELLAQLAAERGEDGQPRYELSLF
                     VLMNQGELVQQIPEGVRLVNPRYAPVSVLEPKGRIYMGMTVVKCLLHRANLIRLWHYHW
                     RAARAMRKEGRLMPDKLLWRVISDGARRFPEEYDLAVAFLEGGSAYYVADHVRAKKKAA
                     FIHIDYQKAGYSRELDRDCYLQYDAVFPIGEQVKRAFLAVYPECSARTRIYHNRIDCEK
                     IRKMSGQPGGFTDDFDGIRLLTVGRLTPQKAYPVAIEAMRQLKAEGYPVRWYVLGEGSS
                     RRELEQHIASCGLKEDFLLLGAVTNPYPYYRQTDIYVHATGYEGKSIAIQEAQTLGCAI
                     VASECNREQITDGEDGILCALDAAAVKEAVGFLIRNPDRRRAYAQAALKRPVNYENEER
                     LLEQLLSEKE"
     CDS             complement(1743..2123)
                     /locus_tag="ctg11_33"
                     /transl_table=11
                     /translation="MNVILILRIFLTAAGVLFLLGDINAYVRQKLTDTIGLLWAFVSVA
                     LILTGVVSVPGAREEEYLVVLLLAVCLLLLILLFKLSKVVSVLSMKNQELAMQVSLLNQ
                     ENERILHRLGILTDEKKDIVRD"
     CDS             complement(2127..3578)
                     /locus_tag="ctg11_34"
                     /transl_table=11
                     /translation="MAGIGIKLQKIYEKKTILAYLTGFGYSAVVTVAPMFVVIGTIMLM
                     SQLLGYENVGYARRGLFSGTLLYIFIFSLLTAAPFNAVLSRYMSDVIYEERYEDILPCY
                     DVGLLLNILLASLLGIPFCAWEHLVGHVNLIFVFTGFCGYIALVLVFYSMLYLSICKDY
                     QKISLYFLTGMAAALACALFFVKVCGREIVYSMLLSLTIGFFLTAVLEYATVKRYFKRN
                     SNRYRRVFSYFGRYWKLVVINFLYTLGLYIHNFVFWNTDLQMRVADTFVFAPTYDLATC
                     LAMFTNLSSTIIFITRVEMHFHTRYKAYSEAVIGGRWEDIKNTKDRMFRQLSAELMNLV
                     RIQFIISTAVYLLCVVVLSQYGFSGRVMQIYPCLAAGYFILFILYAKIIFLYYFNDLTG
                     ALLATLGFCLVTWAGSVLSAGGSDLWYGMGLVAGSFTGFTIAYFRLRFMERHMDEHIFC
                     GGQLFTVKRERMPESMVYTKKQKER"
     CDS             complement(3593..5017)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1045:glycosyl transferase group 1 (Score: 123;
                     E-value: 2.9e-37)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg11_35"
                     /sec_met_domain="Glycos_transf_1 (E-value: 3.9e-23,
                     bitscore: 73.4, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRICIVAEGCYPYVVGGVSSWIHSMIKIFPEYQFVVLAIVANRSL
                     RGKFVYDLPENVVEVHELYLEDADWRPKELKRAARLKLNEREYAALRSLLMNQNVDWDT
                     LFSFFGEKEFSLNELLMGEDFFRAVQECYTVRYAGAVFSDFLWTMRSMYLPLFLTLGMR
                     LPRADVYHCVATGYAGVLGSMAKRRFGCRLLISEHGIYTREREEELIRADWVSGIYKNI
                     WIEQFKKMSKLAYDRADLVTSLYAHARELQIELGCPADKTSITPNGIDPARFDGLKRPE
                     AMEPDMVHIGAVLRVTPIKDVKTMIRAFAYAKRDVPNLKLWIMGPTEEDEEYARECFDL
                     VELMELPDVVFTGRVNVTEYLGGLDFTILTSISEGQPLTVLEGYAAKLPAIATDVGNCR
                     GLLYGEDDDFGEAGILTHIMNVKEIADAMVNLARHPVRRKQMGENGYRRVMAKYKISDM
                     QQTYRKIYETFENIDW"
     CDS             complement(5014..6891)
                     /locus_tag="ctg11_36"
                     /transl_table=11
                     /translation="MVSRRNYLTIAMMFVILLFMFQFTGVMKEQLSEYESNEYADDTTT
                     SFQRSDAFLAEQTSADACEVIYVGEAGGAEESVVKTWCSYRKRTFFCSSSLALLDSLQD
                     DALQVLVVDGSKVTSEEEVAVLRREAQMGVTVIFATLPQSSVIREYRDLRELLGIRAVI
                     ADEIPLAGMHLFSGFLLGGEEIYEVTEPGEEERQDMNPSVPWYTTGAGTKTYMVGTLSD
                     ETIEQTVDDEIRAQYVGMEEEAAKNSLLPAILWRNSVDTAKIFCVNGDYLADISAVGIL
                     DAMMGETYDYDIYPVINAQNLVIADLPAFVSENEEEMQKRYSQSAQAVYQEIVWPSLTS
                     IASRTGAKMTCMMTPQFTYTDEEEPDGENVTYYLKRLKEEHAEAGLSADSREGIPLSEK
                     IKQDQTFWQTYAPSYRFLSLYADGVKSIGEESALPAEIRTVALGSGASEAVGYLNENVT
                     LQPSTSSGIRHTFLDDFKVKCMETALGYSNITLDLYSVTYPEGDEDSWEKMSKKIAANL
                     GTYWKAYEAFDATTLTESDVRIRRFLALDYKQQRAGNVITLSLEHREDAAWFLLRLHGE
                     KVTEVAGGSFEEIEDGVYLILAEEDEVSVEVQTGETWQYQDGGKRGDGT"
     CDS             complement(6912..7829)
                     /locus_tag="ctg11_37"
                     /transl_table=11
                     /translation="MSRIETYFLLLVVLNLCITAAYVLWNEQHWREEPGKRTGGRIRAA
                     VMLLAPVIGPVFFVAGELARHLLFGQSADLEDVIFSKERVRTHFMADEEQERNVVPIEE
                     ALAISDRDSLRTLIMNVVRGDVTDSLGSLALALDSEDTETSHYAASVLRDVLNDFRQHA
                     QELYRQMQKDGREAGDDACLLIEYMYVVLKQNVFHETEQRTFVDMFEEACELLYEKDYR
                     KLTAQYIEWLCELLLRLKEFGRMHYWCNRSRELYPDVLSTYTCYLKMYFTQEKKTEFFR
                     ELDRLKASNIVIDRETLELIRTFS"
     CDS             complement(7826..9997)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010:NAD-dependent epimerase/dehydratase (Score: 62.7;
                     E-value: 6.3e-19)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg11_38"
                     /sec_met_domain="RmlD_sub_bind (E-value: 4.4e-13, bitscore:
                     40.4, seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNILLVGSKCRFLQLLTDKLDKEGHRVFLLTAEDKSVRTSKKIFE
                     TYHFAYDNPCIREVLEGVRPDVTVFMGAYDTGFLWGKGSSTASAYTSGLFQLLMNETAG
                     NVGRFLYLSSEEVFGGEYTQDISCEENCAAYTVRAQAIAAGEELCRSYFNMGYETIVLR
                     LDHLYGEPLTGAEARDICARMSVEGLETGEIRVNPHNRVALLHYSDAVEFLYAVITAKK
                     MTYGVYQISSGETISVRSAAEFVAAELEGVKVVEDTGRERMDPVLSNQRFAEEFGIRIV
                     HKPETEIGREAAYIRRHASSFVRTQSRKKGWSRFGERSREAVRAMIPFAENLLCFLPFF
                     LLNNWMAGSAYFQNIDFYLLYVLLFAIIYGQQQATFSSILAVAGYLAVQMYQRSGFDVV
                     LDVNTYIWIAQLLILGLVIGYMRDRLHAVEEEERHEVDFLSRQVEDISDVNGSNVRIKE
                     ILSNQIVNQNDSFGKLYEITSSLDKYEPSEVLFYAAEVLAKLMDSQDVAIYTVANHSYA
                     RLFSATSPKARMLGNSIHYVQMEELYEKLREKKVFINKTMDERYPLMADAIYSEDEMQL
                     ILMVWGIPWERMTLGQANMLTVIGYLIQNAVVRANRYLSALEQQRYIHGTRILEADAFA
                     SLVNAYLNAREKKLTECALVVFEEGEISREEAAGVLSGMMRQSDYLGELSDGKMYALLA
                     NTSAEDAGMVVERFRSAGFPCRMKEEMEL"
     CDS             complement(10001..10258)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg11_39"
                     /sec_met_domain="PF05402 (E-value: 1.9e-12, bitscore: 38.9,
                     seeds: 461, tool: rule-based-clusters)"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 1.2e-09,
                     bitscore: 29.6, seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQKNRYQLRCAAGKYWLLDMEQDGETYRPPLMLNESGAYIFRQYM
                     AGNTADKIAEELATMYGGTADDMRTDVMQFIRQMELQGIL"
     CDS             complement(10384..11181)
                     /gene_functions="regulatory (smcogs) SMCOG1008:response
                     regulator (Score: 90; E-value: 2.7e-27)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg11_40"
                     /transl_table=11
                     /translation="MEKLNVAIADDNERMLRLLGDIIESDDELNVVGVARDGEEAYHVI
                     KAKEPDVVLLDIVMPKLDGLGVLDRVSQDTSIKKHPAFIMISAIGQEKITEDAFARGAD
                     YYIMKPFDNDIVLSRIKNVRRLAAGRGAEVRKVNAYEKAEETKERNLEADVTDIIHEIG
                     VPAHIKGYQYLRDAIVMSVNDMDMLNSITKILYPTIAKKYQTTSSRVERAIRHAIEVAW
                     SRGKMDTIDEMFGYTIHNGKGKPTNSEFIALITDRIRLEYKMH"
     CDS             complement(11279..12646)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1025:diguanylate cyclase (Score: 140.4; E-value:
                     1.8e-42)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg11_41"
                     /transl_table=11
                     /translation="MLVQNALHLYKKCDDMLKYATALNLLGVIYGATGNETMAVDYLVE
                     GLECAIDYQLNNITTLFYNNIGSRYQELGEHEKAIDYFLKSARELQNPTCIKEERHRSW
                     TLITYLNLAVSYYELNLYELSYKYLEQAERQLDEEVEEMYHYTVLIFKCRLLWQMGKGD
                     YVYEYMEDLLASGEKDSNASDYLNDMKDLCQLFRDMKEYEYWKQTISAVETYTIDQKTV
                     FFQLFLTELWMDYYQTVGNEERYVELCVAHADLYKRQKAIDAKDRATAIDIKVQLREKE
                     AERKRVETMSVTDALTGLGNRYSLEREAVHIIRDAGGERITVGVLDIDCFKQLNDTYGH
                     IQGDRCLKVVADILKEAVMDCGHVYRFGGDEFVMLFPAGMENRIEEIAEAILQKIAEAG
                     IANEHSVVQPNLTISQGYACFVPEGTESGARLIEHADKALYYVKRNSRNAYYIIRE"
     CDS             complement(12822..14042)
                     /locus_tag="ctg11_42"
                     /transl_table=11
                     /translation="MRHKFYFLIQQITWVVFLFLTLFAVKTFERALPDEIYVPFGEKAD
                     YRFGVPVSVTLKDDSEEVFYRLNGQEDAMAEAPFYTVTCKLFGIFPVKDVKVMMVDRQE
                     VTAGGEAIGIYVKTDGILVLGTAKIADAWGNECSPAQNLVQSGDYIVSVNGETVCGKEE
                     LMDKIDSYGSGREIIGVMRKGEYVEVSMNPVKGETGKYRLGIWVRDDLAGVGTLTYYRQ
                     DGSFGALGHAVSDGDTGVQMSLSEGYIYETKIVSIQKGKTGAPGELAGIIDYGKSHCMG
                     SITENSPLGIRGVLNDKAGELEGEVYEVAYKQDIALGKAHIISEVSGERAEYEIEIESL
                     DYSGDEENKGILFKVTDERLLELTGGIVQGMSGSPIIQNGKMIGAVTHVFVSDASMGYG
                     IFIEKML"
     CDS             complement(14039..14140)
                     /locus_tag="ctg11_43"
                     /transl_table=11
                     /translation="MRGYTQRPEPPFLRVAATCVAAFGLQKMVWGQI"
ORIGIN
        1 taaaaatgcc ctgcggttaa gtccctgcag accggtcgtc ggatcggcaa tctttcgtcc
       61 ggtactgatc tttatcatcc agcggaagaa tccgtatgcc agtttcttcg tagcgaagac
      121 cggatactct gcacttccct ccataaaacg cgaacaaagc acgatatccg ggcagcgtcc
      181 gtccgcatcc tgctgtttta gtctctgata gatcaccggt atgttgcaca catcatgctg
      241 tccgtccgca tccatctgga tcacatagga atatttgcgg cggatcgcgt atttatatcc
      301 aagctgcagg gcgctcccgt accccagatt aaagacatgg gataccagcg tatgtccgtg
      361 tgcctttacg acccagttcg tagagtccga ggacgcatca ttcatgacca gaatatccgc
      421 aatctccgcg atctccgggc gttccagctc ctccagcacc cgctctatat ttttctcctc
      481 attgtatgcc ggaatgataa tcagcagttc tttctgtttc ttctctacca tcgtatcttc
      541 cttattcttt ctcggaaagc agctgctcca acagccgttc ctcgttctcg taatttacag
      601 gacgctttaa cgccgcctgc gcgtacgccc tgcgccggtc cggattccgg atcaagaagc
      661 ccacagcttc ctttaccgcc gcagcgtcaa gcgcgcacaa aatcccgtcc tccccgtctg
      721 taatctgctc tctgttacat tcggaagcaa cgatcgcaca gccaagcgtc tgcgcctcct
      781 gtatcgcaat gcttttcccc tcatatccgg tcgcatgcac atagatatcc gtctgccggt
      841 agtacggata gggatttgta accgctccaa gcagcaggaa atcctccttt aatccgcacg
      901 acgcaatgtg ctgctctaat tccctgcggc tgcttccctc gcccagcaca taccaccgga
      961 ccgggtatcc ctccgccttt aactgccgca tcgcttcgat cgcaaccgga tatgccttct
     1021 gcggggtgag tcttcccacc gtaagcaggc ggattccgtc gaaatcatcc gtaaatcctc
     1081 ccggctgccc ggacatcttc cggatttttt cacagtcgat ccgattgtga tagatcctgg
     1141 tgcgtgcact gcactccgga tacacggcga gaaacgcccg ctttacctgt tctccgatcg
     1201 gaaatacggc atcatattgc aggtagcagt cgcgatccag ttccctactg tatcccgcct
     1261 tctgatagtc gatatgaata aacgccgcct tttttttcgc cctgacgtgg tctgccacat
     1321 agtatgcaga accgccctcc aggaatgcaa ctgcaagatc atattcctcc gggaagcgtc
     1381 tggcgccatc cgagattacc cgccacagca gcttgtccgg catcagccgt ccctctttgc
     1441 gcatcgcccg cgcggccctc cagtgatagt gccacagccg gatcaggttg gctctgtgaa
     1501 gcagacattt tacaacggtc atgcccatat agattcttcc ctttggttcg agcaccgaga
     1561 ccggggcata ccttggattg acaagccgca ccccctctgg tatctgctgc accagttctc
     1621 cctggttcat caggacaaag agcgaaagct catatctggg ctgcccgtcc tccccccgct
     1681 cggcagcaag ctgcgcaagc agttccaaca atgccgtctc cgctccggcg cggcttaatg
     1741 tgttaatcac gaacaatatc ttttttttca tctgtcaaaa tccccagcct gtgcaatatt
     1801 ctctcatttt cctgattgag cagggaaacc tgcatggcaa gctcctgatt tttcatggaa
     1861 agaaccgaca ccaccttgct tagcttaaac agcaggatca aaagcaacag gcagactgcc
     1921 agaagaagca ccaccaggta ttcctcctcc cttgcccccg gcacggagac cacgcccgtt
     1981 aaaatcagcg ccaccgagac aaatgcccac agaagtccaa tcgtatcggt cagtttttgt
     2041 ctcacatacg cattgatgtc ccccaaaagg aacaacactc ccgctgccgt cagaaaaatc
     2101 cgcagaatta aaatcacatt catatactaa cgctccttct gtttctttgt atataccata
     2161 ctctccggca tccgctctct cttcaccgta aacagctgtc cgccgcagaa gatatgttca
     2221 tccatatggc gctccatgaa cctgagtctg aaataggcaa tggtaaagcc ggtaaagctg
     2281 cccgccacca gccccatgcc gtaccacagg tcactcccgc cggcagaaag cacgcttccc
     2341 gcccacgtca ccagacaaaa gccgagggtt gccaaaagcg cccctgtcag atcgttaaag
     2401 tagtacagaa aaataatttt tgcatacaga ataaataata taaaatatcc ggcggcaaga
     2461 caaggataga tctgcatcac tcttcccgag aacccgtact gcgaaagcac caccacgcag
     2521 agcagataca ctgccgtcga gatgataaac tgtatgcgca ccagattcat aagctccgca
     2581 gaaagttgcc ggaacattct gtcttttgta tttttgatat cttcccatct tcctccgata
     2641 accgcttccg aatacgcctt gtaacgtgtg tggaaatgca tctctacccg cgtgataaaa
     2701 atgatggtcg acgacagatt cgtaaacatc gccagacagg ttgccagatc atacgtcgga
     2761 gcaaagacaa acgtatccgc cacgcgcatc tgtaaatccg tattccagaa cacaaaatta
     2821 tgaatataca gaccgagggt atacaaaaaa ttgatcacca ccagcttcca gtacctgcca
     2881 aaatacgaaa aaactcttct gtaccggttg ctgttcctct taaaataccg cttcaccgtg
     2941 gcgtattcca acaccgccgt aagaaagaat ccgatcgtga gggaaagcag catactgtag
     3001 acaatctccc taccgcatac ttttacaaaa aagagggcgc aggcgagtgc cgccgccatc
     3061 ccggtcaaaa agtacagcga tatcttctga taatccttac agatggagag gtaaagcatc
     3121 gagtagaaca cgagaaccag tgcgatataa ccgcaaaatc cggtaaacac aaaaatcagg
     3181 ttgacatgtc ccacaagatg ttcccatgcg caaaacggaa ttccgagaag acttgccagc
     3241 agaatgttta aaagcagccc cacatcgtaa cagggcagaa tatcctcata gcgctcctca
     3301 tagatgacat ccgacatata gcgggacagc actgcattaa aaggcgctgc cgtcagaagt
     3361 gaaaagataa agatataaag cagcgttccg gaaaacagtc ctctcctcgc atatcccaca
     3421 ttctcatatc ccaggagctg actcatgagc atgatcgttc cgatcacgac aaacatcggt
     3481 gcgaccgtca cgaccgcact gtagccgaat ccggtcagat atgcaagaat cgtttttttc
     3541 tcatatattt tctggagctt gattcctatt cctgccacag tctctctccc ttctaccagt
     3601 ctatgttctc aaacgtttca taaatcttcc ggtacgtctg ctgcatatcc gaaatcttgt
     3661 actttgccat cacacggcgg taaccgtttt ctcccatctg ttttctgcgg accggatgtc
     3721 tggcaagatt caccatggca tccgcaattt ccttcacatt catgatgtgc gtcaaaattc
     3781 ccgcctcgcc aaaatcatcg tcctcgccgt acaacagtcc gcggcagttt ccgacatcgg
     3841 ttgctatcgc cggaagcttc gccgcatagc cctccagaac cgttaacggc tgcccctcgc
     3901 tgatactggt cagaatggta aaatccagtc cgccgagata ttccgtcaca ttcacccttc
     3961 cggtaaacac cacatccggc agttccatca gctccaccag atcaaaacat tctctcgcgt
     4021 attcctcgtc ttcttccgtc ggccccatga tccataattt taagttaggc acatcgcgct
     4081 ttgcatacgc aaacgcccgg atcatggtct tgacatcctt gatcggcgtc acgcggagta
     4141 ccgcaccgat gtgcaccata tccggctcca tcgcttccgg acgcttcaaa ccgtcaaacc
     4201 gcgccggatc aatcccattc ggggtaatgc tcgtcttatc cgcaggacat cccagttcga
     4261 tctgaagctc tctcgcgtgc gcgtaaaggc ttgtcaccag atccgccctg tcgtatgcaa
     4321 gcttcgacat tttcttaaac tgctcaatcc agatattctt atagatgccg gacacccagt
     4381 ccgcacggat cagttcttcc tcgcgctccc tggtgtagat tccatgctcc gagatcagaa
     4441 gcctgcagcc aaacctgcgc tttgccatgc tgcccagcac gcccgcatat cccgtcgcca
     4501 cacagtgata cacatccgcc ctcggcagcc gcatgccaag tgtcagaaac agcggaaggt
     4561 acatggagcg catcgtccag aggaaatcag aaaacaccgc ccccgcatac cgcaccgtat
     4621 aacattcctg caccgcccgg aaaaaatcct cccccatgag aagttcattc aaagagaatt
     4681 ccttctcccc gaaaaaggag aacagggtat cccagtctac attctggttc atcaacaggc
     4741 tccgcagtgc ggcgtactcc cgctcattta acttcagtct ggctgctctt ttaagttctt
     4801 ttggccgcca gtctgcatcc tccagataca gttcgtgcac ttccaccaca ttctccggga
     4861 gatcgtagac aaactttccg cgcagcgaac ggttcgccac aatcgccagc acgacaaact
     4921 ggtactccgg aaatattttt atcatactgt gtatccagct cgatacaccc ccgacaacat
     4981 agggatagca tccctctgcc acaatacata ttctcatgtg ccgtcaccac gctttccgcc
     5041 gtcctgatac tgccatgttt ccccggtctg cacttccacg gagacctcat cttcctcggc
     5101 aagaatcagg tagacgccgt cttctatctc ttcaaagctt ccgcccgcaa cttctgtgac
     5161 tttctctccg tgcaggcgca gcagaaacca tgccgcatcc tcccggtgct ctaaggaaag
     5221 cgtaatcaca ttgcccgcgc gctgctgctt atagtcaagt gccagaaatc tgcggatgcg
     5281 cacatcactc tctgtcaggg tggttgcgtc aaacgcttca tacgctttcc agtaggtgcc
     5341 caggtttgct gcgatcttct tggacatttt ctcccaggaa tcctcgtccc cttccggata
     5401 agtcacgcta tagaggtcga gtgtgatgtt ggaatagccg agcgccgtct ccatgcattt
     5461 cactttaaaa tcatccagaa acgtatgccg gattccggaa ctcgtcgacg gctgcagtgt
     5521 gacgttctca ttgagatacc ccaccgcctc gctggcacct gatccgagcg caaccgttcg
     5581 gatttctgcc ggaagggcac tctcctcccc gatgctcttt actccgtccg cgtagaggga
     5641 taaaaaccgg taggacggcg cataggtctg ccagaacgtc tgatcctgct ttattttttc
     5701 tgagagtggg atcccttccc tgctgtctgc ggacagcccc gcctccgcgt gctcctcctt
     5761 cagacgtttc agatagtagg tgacgttctc tccatccggc tcttcctcat ccgtatacgt
     5821 aaactgcggc gtcatcatgc aggtcatctt tgcccccgtc cgggaggcaa tggaggtcag
     5881 cgacggccac acaatttcct gatacactgc ctgtgcggac tggctgtagc gcttctgcat
     5941 ctcctcctcg ttctcggaga cgaacgccgg cagatctgca atcacaagat tctgtgcgtt
     6001 gatcaccggg tagatatcgt aatcgtatgt ctcccccatc atggcgtcca gtattccaac
     6061 agcgcttatg tctgcaagat aatccccgtt cacacagaaa atctttgccg tgtccacact
     6121 atttctccag agaatggcag gcagaaggct gttttttgcc gcctcttcct ccattcccac
     6181 atactgtgcc cgtatttcgt catccaccgt ctgttcgatc gtctcatcgg acagcgtgcc
     6241 gaccatatag gtcttggttc ccgcgccggt cgtataccag ggaacagaag ggttcatgtc
     6301 ctgacgctcc tcctccccgg gttccgtgac ctcatagatc tcttccccgc cgagcagaaa
     6361 gccggaaaac agatgcatgc ccgcaagtgg tatctcatcc gcaatcaccg cgcggattcc
     6421 gagaagctcc cttaaatccc ggtactccct tatcacagag ctctgcggca gggttgcaaa
     6481 aatcacagtc acacccattt gtgcctctct gcgaagcacc gccacctctt cttccgacgt
     6541 caccttgctg ccgtccacca ccagcacctg cagtgcatca tcctgcaggc tgtcaagcag
     6601 tgcgagggag ctgctgcaaa aaaacgtccg cttgcggtag ctgcaccatg tctttaccac
     6661 ggattcctcc gctccccctg cttcgcccac atagatcacc tcgcaggcgt cggcagatgt
     6721 ctgttctgcc agaaatgcat ccgaccgttg aaaggatgtt gtggtatcgt ctgcatattc
     6781 gttgctctca tattcactta actgttcttt catgacgcct gtaaactgaa acataaaaag
     6841 cagaatcaca aacatcattg caatcgtcag ataatttctg cgtgatacca tgtcatttcc
     6901 ttcctgccgg actaactgaa cgtccggatc agctctaacg tctccctgtc aatgacgata
     6961 ttggacgctt tcagccgatc cagttcccgg aaaaattcgg ttttcttctc ctgcgtaaaa
     7021 tacattttca aatagcaggt gtacgtggaa agcacatccg gatataattc ccggctccgg
     7081 ttgcaccagt aatgcatccg cccgaattcc tttaagcgga gcagcagttc acacagccat
     7141 tcgatgtatt gcgcagtgag tttccggtaa tctttttcat agagaagttc acacgcctcc
     7201 tcaaacatat ccacaaatgt ccgctgttcg gtctcgtgaa aaacattctg ttttaagacg
     7261 acatacatgt actcgatcag aaggcaggca tcatcccctg cctctctgcc gtccttttgc
     7321 atctgccggt agagttcctg tgcatgctgc ctgaaatcgt tgagcacatc ccgaagcacc
     7381 gacgccgcat agtgggaggt ctcggtgtcc tcactgtcaa gtgccagcgc cagcgatccg
     7441 agagagtccg tgacatctcc tctgaccaca ttcataatca gtgtgcgcag actatcccgg
     7501 tcggaaatcg ccagtgcctc ctcgatcggc accacattcc gctcctgctc ctcatccgcc
     7561 ataaagtgtg ttctgacacg ctccttactg aaaataacat cttccagatc cgccgactgt
     7621 ccgaataaaa gatgccgcgc gagttctccc gccacaaaga agacgggacc gatcaccggt
     7681 gccaaaagca taaccgccgc gcggattctt ccgccggtgc gctttccggg ctcttctctc
     7741 cagtgctgct cattccacag gacatacgcc gccgtgatgc acagattcag taccacaagc
     7801 agcagaaaat acgtttcgat cctgctcata gttccatctc ctctttcatc ctgcacggaa
     7861 agcctgcgct cctaaaacgc tccacaacca ttcccgcatc ctctgcgctc gtgttagcaa
     7921 gcagtgcgta catctttccg tcggagagtt ctccaaggta atcactctgg cgcatcatgc
     7981 cggaaagcac gcccgcggct tcctccctgg agatctcccc ctcctcaaag acaacaagcg
     8041 cgcactccgt cagcttcttc tccctggcgt taagataagc attcaccaga gaagcaaacg
     8101 catccgcctc caaaattctg gtgccgtgga tatagcgttg ctgttctaac gccgagagat
     8161 aacggttcgc acgtacaacc gcgttctgga tcagatagcc gatcacagtg agcatattcg
     8221 cctgtccgag cgtcattctc tcccatggga ttccccacac catcagaatc agctgcatct
     8281 catcctccga ataaatggca tccgccatca gcggatagcg ctcatccatg gttttgttga
     8341 tgaacacttt tttctcccgc agcttttcat agagttcttc catctgcaca tagtgaatgg
     8401 aatttccgag catgcgtgcc ttcggcgaag ttgccgagaa cagacgcgca taggagtggt
     8461 ttgccaccgt atagattgcg acatcctgac tgtccatcag ctttgccagc acctccgcgg
     8521 catagaacaa cacttcactc ggctcgtact tgtccaggct ggacgtgatc tcatacagct
     8581 ttccgaagct gtcgttctgg ttgacgatct gatttgacag aatctccttg atgcgcacgt
     8641 tgctgccgtt gacatccgag atgtcctcta cctgtctgga gaggaaatcc acctcatggc
     8701 gctcctcctc ctccaccgca tgcagccggt cacgcatata gccgatcaca agtcccagaa
     8761 tcagcagctg tgcaatccat atgtacgtgt tgacatccag caccacatca aaaccgctcc
     8821 gctgatacat ctgcaccgca agataccccg ccaccgcaag tatcgaggag aatgtcgcct
     8881 gctgctgtcc gtagataatg gcaaacagca gcacatacag cagataaaaa tcaatgttct
     8941 ggaaatacgc actccccgcc atccagttat ttaacaggaa aaacggaagg aaacaaagca
     9001 gattctccgc gaacggaatc atcgctctta cggcctctct cgaccgctct ccgaaccggc
     9061 tccatccctt ttttctgctc tgtgtccgca caaaagaaga tgcgtgccgc cggatgtacg
     9121 ccgcctccct gccaatctcg gtctccggct tatgtacaat gcgtatccca aactcctccg
     9181 caaatctctg gttggacaaa accggatcca tccgctctct tccggtgtcc tctacgactt
     9241 tcacaccttc cagttccgcc gccacaaact ccgctgcgct tcgcacggaa atcgtctctc
     9301 cggaagaaat ctgatagacg ccgtacgtca tcttttttgc cgtaatcacc gcatacaaaa
     9361 attcgacggc atccgaatag tgtaacagcg ccacacggtt gtgaggattt acccggatct
     9421 caccggtttc cagcccctcc acactcatgc gggcgcagat atcacgcgct tccgccccgg
     9481 taagcggttc cccgtagaga tgatccagcc gcagcacgat cgtctcatag cccatgttaa
     9541 agtaactgcg gcagagttcc tctcccgccg caatcgcctg cgcgcgtacc gtataagccg
     9601 cacagttttc ctcgcacgaa atgtcctgtg tatactctcc cccgaagact tcctccgacg
     9661 agagatacaa aaagcgtccc acattaccag ccgtctcatt catcagcagc tgaaacaggc
     9721 ctgaagtgta cgccgacgcc gtgctgctcc ccttccccca gagaaagcct gtatcatagg
     9781 cgcccataaa gactgtcaca tccggacgca ctccctcaag cacctctctg atgcacggat
     9841 tgtcgtatgc aaaatgatac gtctcaaata tctttttgga cgttctgacc gatttgtctt
     9901 ctgccgtcag caaaaacaca cggtgccctt ctttgtccag tttgtccgtc aaaagctgaa
     9961 ggaagcggca tttgcttccc accaataata tattcatcgt ttacaagatc ccctgtagtt
    10021 ccatttgtct gataaactgc atcacatctg tccgcatatc gtctgcggtc cccccgtaca
    10081 tagtggcaag ctcctccgcg attttatccg ccgtgtttcc tgccatatac tgcctgaaga
    10141 tataagcccc gctctcattt aacatgagcg gcggccgata cgtttctcca tcctgctcca
    10201 tatctaacag ccagtatttt cctgccgcgc acctgagctg atacctgttt ttctgcatct
    10261 gccatcctcc gaaaaatcat cgtataatta tagcacatct gacgctcaaa aggaaccggt
    10321 tatccgaaaa tgaggacata ctcttcttcg gctttgcgcc tcctgaaaaa tatgtcctca
    10381 tcgttaatgc atcttatatt ccagacgtat ccggtcggta atcagtgcga taaactccga
    10441 attcgtcggt tttccttttc cgttgtggat ggtatacccg aacatctcat caatggtatc
    10501 catcttgcct ctgctccacg ccacctcgat cgcatgccgg attgcccgct ccacacggct
    10561 ggaggttgtc tggtacttct tcgcgatcgt gggataaaga attttcgtga tcgagttgag
    10621 catatccatg tcattgacgg acatgacaat cgcatcccgc agatactgat accctttgat
    10681 atgcgccgga actccgatct cgtgaataat atcggtgaca tccgcttcca ggttgcgctc
    10741 ctttgtctcc tccgccttct cataggcatt gaccttgcgc acttccgcac cgcgtcccgc
    10801 cgcaagtctt ctcacattct tgatgcggct taacacgata tcattgtcaa acggcttcat
    10861 aatgtaataa tctgcgccgc gcgcaaacgc atcttccgtg attttctcct gaccgatcgc
    10921 gctgatcata ataaacgccg gatgtttttt tatggaggtg tcctgactca cgcggtctaa
    10981 aacccccaat ccgtcaagct tcggcatcac aatgtcgagc agcacgacat ccggttcttt
    11041 cgcctttatc acatggtatg cttcctcgcc gtcgcgggcg actcctacaa cattcagttc
    11101 gtcatcactt tcgataatat cccctaataa tcgcagcatt ctctcattat catctgctat
    11161 tgcaacattc agtttttcca ttttagcccc tcctgtgaca aaactctttg cttactgatg
    11221 atactgattc caacgcaaga aaatttgtcg aagctagtcg tcaactgaag tatatgcatc
    11281 attcgcgtat gatataatat gcgtttctgc tgtttctctt cacatagtaa agcgccttgt
    11341 ccgcgtgctc aatcagacgc gctccgctct ctgtgccctc cggcacaaag caggcatacc
    11401 cctgggagat ggtaagattc ggctgcacaa ccgagtgctc gtttgcgatt cccgcctccg
    11461 caatcttctg caggatcgcc tccgcgatct cctcgatccg gttctccatc cctgccggaa
    11521 acaacatcac gaactcatcc ccgccaaacc ggtagacatg tccgcagtcc atcactgcct
    11581 ctttcagaat atccgccacc accttcaggc agcggtctcc ctgaatatgc ccgtaggtat
    11641 cgttcagctg cttaaagcag tcgatgtcca aaacgccgac cgtaatccgc tcaccgcccg
    11701 catcccttat gatatgcacc gcctcacgct caagagaata gcggttcccc agcccggtca
    11761 gcgcatccgt cacagacata gtctccacgc gcttgcgctc cgcctctttt tcccgcagct
    11821 ggaccttgat gtcgatcgct gtggcgcggt ccttcgcatc gatcgctttc tggcgcttat
    11881 acagatccgc atgtgccaca cacagttcca catagcgctc ttcgttcccc acagtctgat
    11941 agtagtccat ccacaattcc gtcagaaaca gctggaaaaa gacggttttc tgatcgatcg
    12001 tataggtctc gaccgcagat atggtctgct tccagtattc atactctttc atgtcgcgga
    12061 acagctgaca cagatccttc atatcgttca gataatccga cgcattgctg tctttttcac
    12121 cgctcgccag aagatcctcc atgtactcat acacatagtc cccctttccc atctgccaga
    12181 gcagcctaca tttgaagatc agtaccgtat aatgatacat ctcctccact tcctcgtcaa
    12241 gctgccgctc tgcctgctct aaatatttgt aggaaagctc gtacaggttc agttcgtagt
    12301 aggagaccgc cagattcagg taggtaatca aagtccagga acggtggcgt tcctccttga
    12361 tgcaggtcgg attctgcagt tcccgcgccg actttaagaa atagtcgatc gccttctcat
    12421 gctctcccag ctcctggtac ctggagccga tattgttata aaagagtgtc gtgatgttat
    12481 ttagctggta atcgatcgca cactcaagtc cttcgaccag ataatccacc gccatcgtct
    12541 cgttccccgt ggcgccgtag atcactccga gcagattgag cgctgtggcg tattttaaca
    12601 tgtcgtcgca cttcttgtag agatgaagcg cattctgtac aagcatcgcc gcttcctcca
    12661 gcttgtggtc aaagaatctg gctctgccct cttcgtagta ttcatctgcc agtttttgta
    12721 tatgttcctg ctgttccatt ccgtcttccg tccttaaagc caacaatact gactgtagta
    12781 taccataagt accagacgtt gtaaaagttt ttgtcgtaca atcacaacat tttctcaata
    12841 aagattccgt accccatcga cgcatccgac acaaacacat gcgtcaccgc cccgatcatc
    12901 ttcccgttct ggataatcgg gctgccgctc atcccctgta cgattcctcc ggtcagctct
    12961 aaaagccgct catccgtgac tttaaaaagg attcccttat tttcctcatc cccgctgtag
    13021 tcaagactct ctatctcgat ctcatactcc gctcgctccc cggacacctc cgagatgatg
    13081 tgggcttttc caagcgcaat gtcctgctta taagccacct cgtagacttc tccttccagt
    13141 tctcccgcct tatcgtttaa cacgccacgg atgccaagcg gcgagttctc cgtaatgctt
    13201 cccatgcaat gcgattttcc atagtcaatg atacccgcaa gttctcccgg cgcgccagtc
    13261 ttccccttct ggatgctcac aattttcgtc tcgtaaatgt acccctccga aaggctcatc
    13321 tgcacgccgg tgtcgccgtc gctcaccgca tgtccgagtg cgccaaagct gccgtcctgc
    13381 ctgtagtagg tcagtgttcc gaccccggca agatcatccc gcacccagat tccaaggcgg
    13441 tattttcccg tctcgccttt gaccggattc atggatactt ccacatactc ccccttccgc
    13501 atcactccga tgatctcacg tccgctgccg tagctgtcaa tcttgtccat cagctcctct
    13561 ttcccgcaca ccgtctcccc gttcacgctc acaatataat ccccgctctg caccagattc
    13621 tgcgccgggc tgcactcatt gccccacgca tccgcaatct ttgcagtgcc gagcaccagg
    13681 attccgtccg tcttcacata gataccgatc gcctcgccgc ccgcagtcac ctcctgtctg
    13741 tcgaccatca tcaccttcac gtcttttacc gggaaaatgc cgaacagctt gcaggtaacg
    13801 gtataaaaag gggcctccgc catggcatcc tcctgcccgt ttaagcggta gaacacttcc
    13861 tcgctgtcgt cctttaacgt cacgctcacc ggaacgccaa accggtaatc cgccttttcc
    13921 ccgaacggaa cgtagatctc atccggcagt gcccgctcaa acgtctttac ggcaaacagc
    13981 gtcaaaaaca aaaaaacaac ccacgtgatc tgctgtatca aaaaataaaa tttatgtctc
    14041 atatctgccc ccataccatt ttctgtaacc caaaggccgc cacacaagtc gccgccaccc
    14101 ttaaaaaggg tggctcggga cgctgggtgt aaccccttgg t
//
