LOCUS       c00072_gnlPro..        12772 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|IIKKHECN_72.
ACCESSION   c00072_gnlPro..
VERSION     c00072_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 00:58:50
            Original ID  :: gnl|Prokka|IIKKHECN_72
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12772
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12772
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1547:6835]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1548..6835
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..12772
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..12772
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             2..169
                     /locus_tag="ctg72_1"
                     /transl_table=11
                     /translation="IQPEEMLTFFSNEFPSAFSSEIPRCGLLIILLIKAKHDMLIVAVP
                     YCVPFLFCKK"
     CDS             166..1419
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S11"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg72_2"
                     /sec_met_domain="Peptidase_S11 (E-value: 1e-51, bitscore:
                     165.4, seeds: 11, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRDAYTSVKSFWENGMYRRFLSLLLSMSLLIFSPVRVRAQDVPAE
                     SELYAKSAVLMDADSGRILYEKNGHEAMANASTTKILTCIVALENCDPASVVTVSKNAA
                     SQPKVHLGMHEGQQFYLRDLLYGLMLESYNDCAVAIAEFAAGEVQEFAALMNAKAEELG
                     CEDSYFITPNGLDAKDDAGFHHTTAADLAKIMKYCIKESLKSDEFLEITRTAQYSFSDA
                     EGKCTYQCTNHNAFLQMMEGALSGKTGFTGTAGYCYVGALQREDKTLIVALLACGWPNN
                     KTYKWSDTRKLMNYGLEQFKKIDLLQIEPDEAELAPIEVRDGQGGQIGETVYLKPVVRN
                     YAGEESILAPLSSEVTLKYEIADRLYAPVKSGDYIGKIRYMLGEETLAERCVVAGETIG
                     KIDYPWCLGQVLRLLWIE"
     CDS             1548..3041
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Vparvula"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg72_3"
                     /sec_met_domain="CT_Vparvula (E-value: 6.5e-125, bitscore:
                     407.1, seeds: 132, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKPHPKWMWTTIYRWRAKRMNSSNDSLAMQRITRLVDENSFIEIG
                     SLVTARSTDFNLAATDTPSDGVITGHGLIDGNLVFIYSQDASVLNGTIGEMHAKKIAAV
                     YDMAMKMGAPVIGFIDCAGVRLQESVDALDGFGLIYAKEVAASGVVPQISAVFGSCGGG
                     LAVVPALSDFAFIEESKGKMFVNSPNAIDGNRIEKCDTSSAAFQADENGCIDATGTEDE
                     ILADIRELVGMLPLNNEGDVYTDECVDDLNRACESMDAMKGDPRYLLSEISDSHTFFET
                     KAGYARDMVTGFIKLNGMTVGAVANCTTVYDEEGKESEKFDNVLSAKGCEKAAEFVSFC
                     DAFEIPVLTLTNVKGYKACKCSEKRLAKALAHLTSAFAGATCPKVNLITGEAYGTAYVA
                     MNSKSIGADFVYAWPDAKVGMMDADLAVKIMYADASADELAEKAKEYDALQGSVMTAAR
                     RGYVDLIVDPADTRKYLVDAFELLYTKCAYTPDKKHGTK"
     CDS             3028..3780
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg72_4"
                     /sec_met_domain="OAD_gamma (E-value: 4.9e-26, bitscore:
                     81.0, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEQNRKVKFMKKKLSLILCLCFMALGLAACGTDPTTVDYFGMTYD
                     ELQSSMEQEVSALVGLTDDNRTYIQSYGSDTAMKLVESWDEATSDVGAYQGLGEFNITK
                     AQKTLTVDQYVEYQNREVIVSYIYTYNYETEQPELTDASADKVYTLGEKMEKAALNTLM
                     GMGTVFVVLILISLIIYCFRFISVIQNKAAGKGKKNEAEAGAVVEQIGQREEQLTDDLE
                     LVAVISAAVAASTGASADSFVVRSIRRR"
     CDS             3822..4187
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 61.7; E-value:
                     1.5e-19)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg72_5"
                     /sec_met_domain="Biotin_lipoyl (E-value: 2.8e-20, bitscore:
                     61.7, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKSYTITVNGNVYDVTVEENGAVSAPAAAPRRAAAPAAAPAAKPA
                     AAAGAGSVKIEAGAAGKVFKLEKSVGDAVKKGDSIMVLEIMKMETPVVATQDGTVASIN
                     VSVGDMVEAGALLATLN"
     CDS             4203..5351
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg72_6"
                     /sec_met_domain="OAD_beta (E-value: 2.7e-157, bitscore:
                     512.8, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSYFSETMGNLLHQTAFFNLTWGNFVMIIVACFFLYLAIAKGFEP
                     LLLVPIAFGMLLVNIYPDIFADPEQMSNGVGGLFHYFYVLDEWSILPSLIFLGVGAMTD
                     FGPLIANPISFLLGAAAQFGIFGAYFLAIMMGFNDKAAAAVSIIGGADGPTSIFLAGKL
                     GQSGLMGPIAVAAYSYMALVPIIQPPIMKLFTTKKERAIKMENLRPVSKLEKILFPIVV
                     TVVVCTILPTTAPLVGMLMLGNLFRESGVVRQLTDTASNALMYIVVILLGTSVGASTSA
                     EAFLNTTTLKIVALGLIAFMFGTAAGVLFGKLLCFLTKGKINPLIGSAGVSAVPMAARV
                     SQKVGAEEDPTNFLLMHAMGPNVAGVIGTAVAAGVFMAIFGI"
     CDS             5417..6835
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: HMGL-like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: PYC_OADA"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg72_7"
                     /sec_met_domain="HMGL-like (E-value: 9.3e-46, bitscore:
                     146.1, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="PYC_OADA (E-value: 1.2e-59, bitscore:
                     191.1, seeds: 434, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSEVVKKPLKITETVLRDAHQSLIATRMTTEQMLPIVDKMDKVGY
                     NAVECWGGATFDACLRFLKEDPWDRLRKLRDGFKNTKLQMLFRGQNILGYRPYADDVVE
                     YFVQKSIANGIDIIRIFDCLNDVRNLQTAVTACNKEKGHAQVALSYTLGDAYTLDYWME
                     MAKKVEDMGADSLCIKDMAGLLVPTKATELIQALKSATNLPIELHTHYTSGVASMTYMK
                     AVEAGCDIIDTAMSPFSMGTSQPATEVMVEAFKGTEFDTGLDQNLLAEIADYFRPMREE
                     ALESGLMNPKVLGVNIKTLLYQVPGGMLSNLLSQLKEQGKEDKFEEVLAEVPRVRKDLG
                     EPPLVTPSSQIVGTQAVFNVLMGERYKVATKETKDVLLGKYGQTVKPFNPEIVDKVLGE
                     EKKNAITCRPADLLEPELDKIEAEMKQWKQQDEDVLSYALFPQVATEFFKYREAQQKKV
                     DASVADTKNGAYPV"
     CDS             7039..8808
                     /locus_tag="ctg72_8"
                     /transl_table=11
                     /translation="MRKKENRLKTAVFVLSAGVFFGVCPSIVLADEPGEWREENGSLYW
                     YENGIKQGTEGRGKEIYDPASDGWYWLDAIDGGKKAVGKDVYQESWAGPYADREDGTGK
                     WVRYDTSGKMVKGWDVTERGTYYFDQTTGAMAKGETEIDGIPCVFDRETGIGWNLQWQE
                     KEGARYWYEGGKRQGLEGRGKEIYDPASDAWYWLDSDAQGKMAVNKDVYQPYTIQGQDE
                     TGKWVRYDADGHMVKGWDRQNESTYYFDQTTGAMAKGVAKIDGVSYYFNETTGVCEGEY
                     TPSDSSEPTNVTTYTANDQVSEYTENELDASGNVVKSTTYSASGVKKTERTDAFDQYGN
                     QIRGTYVIYRGGEVYSTATDETVYEYNADGQPLSMTCYNDSQMFSRVLYTYDNGKTAKV
                     EYYVPLDGEEELSNYEQYFYENGRCVRKENYVLSYTDGAWNIRLDTSDYYAYNSNGNLI
                     RETNKSARGNVNYYYTYDYDASGNLIAKGCYAKDDSQQWKEVWTYEGMLLVSDYYYSEE
                     ALGYYIIYENRQRSGHLYQKIEKSYAGDGTYSGKRVYTYEGXXXSVRFTMKRIVAKGKV
                     RGKRTTRFPSLTV"
     CDS             9046..9978
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SIS"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg72_9"
                     /sec_met_domain="SIS (E-value: 1.4e-24, bitscore: 76.1,
                     seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNTNDLSNRINDAYSKLSKGQKRLATYITDNYDKAVFLTAAKLG
                     EVVGVSESTVVRFATHLGYKGYPEFQSALEELVRNKLNSIQRMEVTYGRISQSKILETV
                     LKSDADKIHSTLEKIDQNAFELAVDTILHAKHIYIIGIRSCAPLASFMAFYFTLMFPNV
                     HLIQTSSSSEIFEQMVRIGKEDVIIGISFPRYSMRTLKAMEFANNRSAKVITLTDSVHS
                     PMNLYSSCNLIADSDMASIVDSLVAPLSVINALIVALCMKKQNEVAKTLEMLEDIWDEY
                     QVYENDEINYIDDSIKMRYGKVGDAELYE"
     CDS             9971..11200
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HI0933_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027:FAD binding domain (Score: 58.4; E-value:
                     2.2e-18)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg72_10"
                     /sec_met_domain="HI0933_like (E-value: 4.8e-137, bitscore:
                     446.5, seeds: 46, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSKVIVVGGGPAGMFAAIAAAERGHEVVLLEKNEKLGKKLYITGK
                     GRCNITNAGDMDTLFANVMTNPKFLYSAFYDYDNQRVIDFFEENGLATKVERGNRVFPV
                     SDHSSDVIATLQRVLKRTGVMVQLHAEVRQILTGEGAVRGVKLADGSVLEAERVILATG
                     GFSYQTTGSTGDGYRFARELGHTVTQITPSLVPFYVKETCAARMQGLALKNVQVRIRDG
                     KKLLYDEFGEMLFTHFGVSGPLILSASAAIKPGRVEKELAMEIDLKPALTEEQLDARLL
                     REFEEAKNKQFKNAVVHLFPAKMIPVMLEAGAIDPEKKVNEITREERMGFVHLIKAFPL
                     TLCGVRDFNEAIITRGGVSVKEVNPSTMESKLVPGLYFCGELLDLDAMTGGFNLQIAWS
                     TGHLAGESIE"
     CDS             11219..11881
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Cytidylate_kin"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg72_11"
                     /sec_met_domain="Cytidylate_kin (E-value: 5.1e-81,
                     bitscore: 261.1, seeds: 12, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSMNIAIDGPAGAGKSTIAKKLAKKLAFVYVDTGAMYRAMAYYFL
                     QNGIAPDDEQAIAAACPKVDVTIVYENGEQQVLLNGENVNGVIRTEEVGNMASATSVYP
                     VVRTKLVELQRQLATKTDVIMDGRDIGTCVLPDAQVKIYLTASVATRAKRRYDELTAKG
                     TQCNLEEIEKDIEDRDYRDMHRETSPLKQAKDAVLVDSSEMNIDEVVDAIYQIYARV"
     CDS             11887..12738
                     /locus_tag="ctg72_12"
                     /transl_table=11
                     /translation="MNVILAKSAGFCFGVKRAVDTVYERILEKEPLYTFGPIIHNEEVV
                     RDLEEKGVVVVNDVDELAGKPQGTVIIRAHGVERGVCEKIQTLGFSIVDATCPFVLKIH
                     RLVERYSGEDCHIVIVGNASHPEVKGIKSWSNAEDTRVIGTREEAEKYDASHGKKVCIV
                     SQTTFNYNKFQELVEIIKEKGYDIIVLNTICNATEERQTEARAIAEQVDAMIVIGGRNS
                     SNTQKLFEICKNECKNTYYIQTVKDLDLAEVRSVDNVGITAGASTPNNIIEEVQKNVRN
                     EF"
ORIGIN
        1 cattcagccg gaagaaatgc tcacattttt ctccaacgaa tttccatctg cattttcatc
       61 tgaaatccca cggtgtggtc ttctgataat attacttatc aaagcaaagc acgatatgct
      121 tattgtggca gttccttatt gcgtgccgtt tctgttctgc aaaaaatgag ggacgcatat
      181 acatcagtga agtcattttg ggagaatggc atgtatcgac gctttctttc tctattgtta
      241 agtatgagct tgcttatttt ttcgcctgtg cgtgtccggg cgcaggatgt gccggcagag
      301 tcggaactgt acgcaaaatc tgccgttttg atggatgcgg attccggaag aattctctat
      361 gagaaaaacg ggcatgaagc gatggcgaat gcgagtacga caaagatttt aacctgtatc
      421 gtggcactgg aaaactgtga tccggcgagc gtggttacgg tgtcaaaaaa tgcggcgtcc
      481 cagccgaagg tacatctggg gatgcacgag ggacaacagt tttatctgag ggatctttta
      541 tatggcctga tgctggaatc ctacaatgac tgtgcggtgg ccatcgcgga atttgcggcg
      601 ggggaggtgc aggaatttgc cgcgctgatg aatgcgaagg cagaggaact cggctgtgag
      661 gacagctact ttattacacc gaacggactg gatgcgaagg atgatgccgg gtttcatcac
      721 acgacggcgg cagaccttgc taagattatg aaatattgta ttaaggaatc gttaaaaagc
      781 gacgaatttc tcgagattac acggacggcg cagtattctt tttctgatgc agaggggaaa
      841 tgcacgtacc agtgcacgaa ccacaatgca tttttgcaga tgatggaagg ggcgctttcc
      901 ggaaaaacgg gatttaccgg aaccgccgga tactgctatg tcggagcgct gcagcgggag
      961 gacaaaacgc tgatcgtggc gctgctcgcc tgtggatggc cgaacaacaa gacctataag
     1021 tggtccgaca ccagaaaact catgaattac ggattggagc agttcaaaaa gatcgacctg
     1081 ctgcagattg agccggacga agcggagctt gcgcccatag aggtgcggga cggacagggc
     1141 ggacaaatcg gcgaaacggt gtatttaaaa ccggttgtca ggaactatgc aggggaggag
     1201 agtatcctgg cgccgctaag cagtgaggtt acgcttaagt atgagattgc agaccggctg
     1261 tatgcaccgg tgaagagcgg cgattacatt gggaagattc gttatatgct gggggaggag
     1321 acgctcgcgg agcgatgtgt ggtagccggg gagacaatcg gaaagatcga ttatccgtgg
     1381 tgtctggggc aggtgcttcg gcttctctgg atcgaataaa aaacacaaac aaaaagcgtc
     1441 aaaaaattaa caatttactt gaaatattgc agaaaagcaa ttataattta acatagcgta
     1501 atttgttgaa tttttataca aagacgcatg gatttacatc attcactatg aagccgcatc
     1561 ccaaatggat gtggacaaca atttatagat ggagggcaaa aagaatgaat agtagcaatg
     1621 atagcctggc tatgcagcgc atcaccaggt tagtcgacga gaacagtttc attgagatcg
     1681 gttctctcgt aaccgcaaga agcacagatt ttaatcttgc agcaacggat actccttccg
     1741 acggagtcat cacaggacac ggcctgattg acggcaatct ggtgttcatt tacagccagg
     1801 acgcttctgt tttaaacgga acaatcggcg agatgcatgc gaagaagatc gctgcagtgt
     1861 atgacatggc gatgaagatg ggagcaccgg tgatcggctt tatcgattgc gcgggagtcc
     1921 gtttacagga gtctgtagat gcgcttgacg gcttcggact gatctatgca aaagaagttg
     1981 cagcatccgg cgtggttccg cagatttcag ccgtattcgg cagctgcggc ggtggactgg
     2041 cagtggtacc ggcactttct gattttgctt ttatcgaaga atccaaagga aagatgtttg
     2101 tgaattctcc gaacgcaatt gacggaaacc gcatcgagaa gtgcgacaca tcatctgcgg
     2161 cattccaggc agatgagaac ggctgcatcg atgcgacggg aacagaggat gagatccttg
     2221 cagacatccg tgagctggtc ggcatgcttc cgctcaacaa cgagggagat gtctacacag
     2281 acgagtgtgt ggatgacctg aaccgtgcat gcgagagcat ggatgccatg aagggcgatc
     2341 cgagatatct tctcagtgag atttcggaca gccatacatt cttcgagaca aaggcaggct
     2401 atgccagaga tatggtgacc ggatttatca agttaaacgg tatgacggtc ggcgcagttg
     2461 caaactgcac aacggtatac gacgaagagg gcaaagagag cgagaagttt gacaatgttc
     2521 tttctgcaaa gggatgtgag aaggcagcag agttcgtatc tttctgcgac gcattcgaga
     2581 tcccggtact gactctgacg aatgtcaagg gctacaaggc atgcaagtgc tctgagaagc
     2641 gtcttgcaaa ggcacttgct catctgacct ccgcatttgc gggagctaca tgtccgaagg
     2701 tgaacctgat cacgggagag gcatacggta ccgcttatgt tgctatgaat tccaagtcta
     2761 tcggtgcgga tttcgtatac gcatggccgg acgcaaaggt cggcatgatg gatgcggatc
     2821 ttgcagtaaa gatcatgtac gcggatgcat ctgcggatga gcttgcagag aaggcaaagg
     2881 aatatgatgc actgcagggc agcgttatga cagcagccag aagaggctat gtggatctga
     2941 tcgttgatcc ggcagatacg agaaagtatc tggtagatgc gtttgagctg ttatatacaa
     3001 agtgtgcata tacaccggac aagaaacatg gaacaaaata gaaaggtgaa gtttatgaag
     3061 aaaaaattat ctcttatact ttgtctttgc tttatggctc tgggacttgc agcatgcgga
     3121 acagatccga caacggttga ctatttcgga atgacttacg atgaactgca gagcagcatg
     3181 gaacaggaag tttccgcgct ggttggtctt acggacgaca acagaaccta tatccagtcc
     3241 tacggcagcg atacggcaat gaaacttgtc gagagctggg atgaggcgac aagtgatgtc
     3301 ggcgcatatc agggacttgg agaattcaat atcacaaagg cacagaaaac cttaacagta
     3361 gatcagtatg tagagtatca gaatcgtgaa gtcatcgttt cttacatcta tacatacaat
     3421 tacgagaccg agcagccgga gcttactgat gcatccgcgg acaaggtata tacgctgggt
     3481 gagaagatgg agaaggctgc gttaaatacc ctgatgggaa tgggaaccgt attcgtggtt
     3541 ctgatcctga tcagccttat tatttactgt ttccgcttta tctctgtaat acagaacaag
     3601 gcggccggca agggcaagaa gaacgaggca gaggcaggcg ctgtggtaga gcagatcgga
     3661 cagcgtgaag agcagcttac cgatgatctt gaacttgtgg cagttatttc cgcagcggtt
     3721 gcggcaagca ccggtgcatc cgcggattct ttcgttgtga gatcgatccg cagacgctaa
     3781 ttcgtataaa tgaaaagaaa tcatattagg aggatatttc aatgaaaagc tatacaatta
     3841 cagtaaatgg caatgtatat gatgtaaccg tagaagagaa cggcgcagtg agcgcaccgg
     3901 cagcagcacc gagacgtgca gcagcaccgg cggcagcacc tgcagcaaag ccggctgcag
     3961 cagcaggcgc aggcagcgtt aagatcgagg caggcgcagc aggaaaggta ttcaaacttg
     4021 agaagtctgt cggtgatgcc gttaagaagg gagacagcat catggttctt gagatcatga
     4081 agatggagac tccggtcgtt gcaacgcagg acggtacggt agcaagtatc aacgtaagtg
     4141 ttggagatat ggtagaagcg ggcgcattac ttgcaacatt aaactaattt aggaggaaga
     4201 caatgagcta ttttagtgag acaatgggga acctcctgca tcagaccgct ttctttaacc
     4261 ttacctgggg aaattttgtg atgatcattg tcgcatgctt tttcctgtat ctggctatcg
     4321 cgaaggggtt tgagccattg cttcttgttc cgattgcatt cggtatgctg cttgtaaata
     4381 tctatccgga tatttttgca gacccggagc agatgagcaa tggtgtaggt ggtttattcc
     4441 actactttta tgtgttagac gagtggtcaa tcttaccgtc tctgattttc cttggagtcg
     4501 gtgctatgac agatttcgga ccgctgattg caaatccgat cagtttcctg cttggagctg
     4561 cagctcagtt cggtattttc ggagcgtact tccttgcaat catgatgggc tttaatgata
     4621 aggcagcagc tgctgtttcc atcatcggtg gagccgatgg accgacctcc attttccttg
     4681 ccggaaagtt aggacagtcg ggactgatgg gaccgatcgc tgtggcggca tattcctata
     4741 tggcgcttgt gccgatcatc cagccgccaa ttatgaagct gtttacaacc aaaaaagagc
     4801 gcgccatcaa gatggagaac ttaagaccgg tttccaagct ggagaagatt ctcttcccga
     4861 tcgtggttac ggtggttgta tgtacgattc ttccgacgac agcgccgctg gttggtatgc
     4921 tgatgctcgg taacctgttc cgcgagagcg gtgtggtccg ccagctgacc gataccgcat
     4981 ccaacgcatt gatgtacatc gtagttatcc tgctcggtac ttccgtaggt gcatctacga
     5041 gtgcggaggc gttcttaaat acaacgacat taaagatcgt tgcacttgga ctgattgcat
     5101 ttatgttcgg tacagcagcc ggtgtcctgt ttggtaagct gttatgcttc ctcacaaagg
     5161 gcaagatcaa tcctctgatc ggatctgccg gtgtatctgc cgttcctatg gcagcccgtg
     5221 tatcccagaa agtcggcgcg gaggaagatc cgacgaactt cctgctgatg catgcgatgg
     5281 gaccgaacgt tgccggcgtt atcggtactg cagtagcagc cggtgtattc atggcaattt
     5341 tcggaattta gtgaaagagc aaatgccgtc atagacggat agcggtatca aagtatccgc
     5401 tgataaggag gaaaaaatgt cagaagttgt taaaaaacct ttaaaaataa cagagacggt
     5461 gctgcgtgat gcgcaccagt ctctgattgc gacaagaatg acaaccgagc agatgcttcc
     5521 gatcgtagac aagatggata aggtcggata caatgcggtt gagtgttggg gcggtgctac
     5581 cttcgatgca tgccttcgtt tcctgaaaga agatccgtgg gatcgtctcc gcaagttaag
     5641 agacggattt aagaacacca agcttcagat gctgtttcgt ggacagaaca tcttaggata
     5701 tcgtccgtat gcagatgatg tggtagagta ttttgtacag aaatctatcg caaacggtat
     5761 tgatatcatt cgtattttcg actgcttaaa cgatgtccgc aacctgcaga cagccgttac
     5821 cgcatgtaac aaagagaaag gacatgcaca ggtcgcatta tcctatacac ttggcgatgc
     5881 ctacactctg gattactgga tggagatggc gaagaaggta gaggatatgg gtgctgattc
     5941 cttatgtatc aaggatatgg caggtctttt ggttccgacg aaggcaaccg agctgattca
     6001 ggcattaaag tctgcaacca accttccgat cgagctccat acacactata cttctggtgt
     6061 cgcttccatg acatacatga aggcggttga ggcaggctgt gacattatcg atacagcaat
     6121 gtctccgttc tccatgggaa ccagccagcc ggcaaccgag gttatggtag aggcattcaa
     6181 gggcacagag ttcgataccg gtctggatca gaacctgtta gctgagatcg ctgactactt
     6241 ccgtccgatg cgtgaggaag cgttagagag cggtctgatg aacccgaagg ttctcggcgt
     6301 taacatcaag actctgttat atcaggtacc gggtggtatg ttatccaacc ttctgtctca
     6361 gttaaaagag cagggcaagg aagacaagtt cgaggaggtt cttgcagagg ttccgcgtgt
     6421 gcgtaaagac ctcggtgagc cgccacttgt tacaccgtcc tcacagatcg ttggtacaca
     6481 ggctgtgttc aacgtactga tgggagagcg ctacaaagtg gcaaccaagg agaccaaaga
     6541 cgtactgctt ggaaagtacg gtcagactgt aaaaccgttc aacccggaga tcgtagacaa
     6601 ggtacttggc gaggagaaga agaacgccat tacctgccgt ccggcagatc tgcttgagcc
     6661 ggagctggat aagatcgagg ctgagatgaa gcagtggaag cagcaggatg aggatgtact
     6721 gtcctacgca ctgttcccgc aggttgcaac cgaattcttc aagtaccgtg aggcacagca
     6781 gaagaaggtc gatgcaagcg tcgcagatac caagaacgga gcatatccgg tataatcaaa
     6841 aaacagttat aacaaaaagc gggtgagcag tcacctgctt tttgttttaa aaatgggaaa
     6901 attatgaatg cagggtattt gcagtaacat ttcattgaaa aaaagagagt gtttcagtat
     6961 cataggaata tgaatcgcag gatgatttga gatgcagtat cgaatgcaaa acagtaaaac
     7021 aacaaaaaag aggatgacat gagaaaaaaa gagaataggt tgaaaacagc agtatttgtt
     7081 ttgagcgcag gggtgttttt tggtgtatgc ccgtcgattg tgctggcaga tgagccggga
     7141 gaatggcggg aagaaaatgg cagtctctat tggtacgaaa atggcataaa gcagggaaca
     7201 gaaggaaggg gcaaggagat ttatgatccg gcgagcgatg gctggtattg gctggatgcc
     7261 attgatgggg ggaaaaaggc ggtcggaaag gacgtgtatc aggaatcatg ggcaggacct
     7321 tatgcagacc gtgaggacgg caccgggaaa tgggtgcgct atgataccag tgggaaaatg
     7381 gtaaaaggct gggatgtgac ggagagaggt acatactatt ttgaccagac gaccggagcg
     7441 atggcaaaag gagaaacgga gatagatgga ataccatgtg tttttgaccg ggagacgggc
     7501 attggctgga atctgcaatg gcaggagaaa gagggggcac gatactggta tgaaggagga
     7561 aaacgtcagg gactcgaagg cagagggaag gaaatctatg atccggcaag tgatgcatgg
     7621 tactggctgg acagcgatgc gcaggggaaa atggcggtaa acaaggatgt ttatcagccc
     7681 tatacaattc agggacagga tgagaccgga aaatgggtac gctatgatgc agatggacat
     7741 atggtaaaag gctgggacag acagaatgaa agtacctatt attttgatca gacaactgga
     7801 gcgatggcaa agggcgtggc gaagattgat ggtgtcagct attattttaa tgaaacgacc
     7861 ggtgtttgtg aaggggagta tacaccatca gacagcagtg agccaacaaa tgtgacaacc
     7921 tacacggcaa acgatcaggt cagtgaatat acagaaaatg agttggacgc gtcaggcaat
     7981 gtggtaaaaa gtacaactta cagtgcatca ggagtaaaaa aaacagaacg taccgatgca
     8041 tttgatcagt acggaaatca gatccgggga acttatgtta tatatcgggg aggagaagtt
     8101 tattcgacag caacggatga gacagtgtat gagtataatg ccgacggtca gccattatcc
     8161 atgacatgtt ataatgattc acagatgttt tcacgggtac tttatacata tgacaatgga
     8221 aagactgcaa aagtagagta ttatgttcca ctggatgggg aagaagaatt aagtaattat
     8281 gaacagtatt tttacgaaaa cggaagatgt gttcgaaagg aaaattatgt gctcagctat
     8341 acagatggtg cgtggaatat tagattggat acatcggatt attatgcata taacagcaat
     8401 ggaaatctga tccgtgagac caataagagc gccagaggga atgtgaacta ctattataca
     8461 tatgattatg atgcgagtgg caatttgatt gccaagggct gttatgcaaa agatgacagt
     8521 cagcagtgga aggaagtctg gacatatgag ggaatgcttc tggtaagcga ttattattac
     8581 agtgaagaag ccctgggata ttatattatc tatgaaaaca gacagcgcag cggtcattta
     8641 tatcagaaaa tagaaaaatc ttatgcagga gatggaacgt attccggtaa aagggtatac
     8701 acttatgaag gnnnnnnnnn nagcgtgagg tttaccatga agaggattgt ggcaaaaggg
     8761 aaggttagag ggaaacggac aacccggttt ccttccctta ccgtatgaca ccgccggtaa
     8821 tccgttttct ggagcagccg gcaggcttcg ttgcaaagtt atccggcatc cggtgaatga
     8881 tgaaaaatct ttcgatgata acaatgctgt tggtttaata tatgcagcgt tggaaaatgc
     8941 gctgcatgtg aggaaagttc catgtacaat ttcttgcaaa acacaatgta tttgatataa
     9001 taaaaacatt gggtggatca caattccgca gaagtgaggg aaagtatgag caatacaaat
     9061 gacctgagta accgcatcaa tgatgcttac agcaagctga gcaaagggca gaaacgtctg
     9121 gcaacctaca ttacggacaa ttatgacaag gcggtatttc tgaccgccgc aaagctgggt
     9181 gaggttgtgg gcgtgagcga gtccacggtg gtgcgctttg cgacacatct gggatataag
     9241 ggctatccgg aattccagag tgcgctggag gaactggtgc gcaataagct gaactccatt
     9301 cagcgcatgg aggttactta cggcaggatc agtcagtcga agattcttga gacggtgctg
     9361 aaatccgacg cggacaagat tcattccaca ctggaaaaga ttgatcagaa tgcatttgaa
     9421 ctcgcggttg acacgattct gcacgccaaa catatctata tcatcggaat ccggagctgc
     9481 gcgccgcttg ccagcttcat ggctttttat tttaccctga tgtttccaaa cgttcatctg
     9541 attcagacaa gcagttcgag cgagattttt gaacagatgg tgcgcatcgg caaggaggat
     9601 gtgatcatcg gaatcagttt cccacgttat tccatgcgta ccttaaaggc gatggaattt
     9661 gccaacaacc ggagcgcaaa ggtaatcaca cttaccgaca gcgtgcattc tccgatgaat
     9721 ctctattctt cctgcaatct gattgcggac agcgatatgg cttccattgt ggattccctg
     9781 gttgccccgc tgtcggtgat caatgcgctg atcgtggcgc tctgcatgaa aaagcagaac
     9841 gaggtggcga aaacgcttga gatgttagag gatatctggg acgaatacca ggtttacgag
     9901 aacgatgaga tcaattatat cgatgattcc atcaagatgc ggtatggaaa agtaggagat
     9961 gcggaactgt atgagtaagg tgatcgtagt cggcggcggg ccggcgggaa tgtttgctgc
    10021 cattgcggcg gcggagcggg gacatgaggt cgttttgctc gagaaaaatg aaaagcttgg
    10081 gaaaaagctc tacatcaccg gcaaagggcg gtgcaacatc acgaatgcgg gggatatgga
    10141 caccctgttt gccaatgtga tgacgaaccc gaagtttttg tacagcgctt tttacgatta
    10201 tgacaatcag agagtgattg atttttttga ggagaatggt ctggcgacga aggtggagcg
    10261 cggcaaccgt gtattcccgg tatcggatca ttcttcggat gtgattgcca cgctgcagcg
    10321 ggtactaaag cgcacgggtg ttatggtgca gcttcatgcg gaagtgcggc agatcctcac
    10381 cggggaaggc gcggtgcgcg gtgtgaagct tgccgacgga agcgttcttg aagcagagcg
    10441 cgtgattctt gcaaccggag gattttctta tcagacgacc ggttcgaccg gagacggcta
    10501 tcgttttgcg agggaactcg gacatacggt gacacagatt acgccgtcac tggttccgtt
    10561 ctacgtgaag gagacctgcg cggcgaggat gcaggggctg gcgctgaaaa atgtgcaggt
    10621 gcgcatccgg gacggaaaaa agctgttgta tgacgaattc ggcgagatgc tctttaccca
    10681 tttcggggta agcgggccgc tgattttaag cgccagtgcg gcaatcaagc cgggccgcgt
    10741 ggagaaggaa ctggcgatgg agatcgactt aaagccggca ctcacggagg aacagctgga
    10801 tgcgagactt ctgcgtgaat tcgaggaggc aaagaataag cagtttaaaa acgccgtcgt
    10861 gcatctgttc ccggcgaaga tgattccggt gatgttagaa gccggagcga ttgatccgga
    10921 gaagaaggtc aacgagatca cgagagagga gcggatggga tttgtgcatc tgatcaaggc
    10981 gtttccgctg acgctctgcg gtgtcagaga tttcaatgaa gcgatcatca cacgcggggg
    11041 tgtcagcgta aaggaagtga acccttccac gatggaatca aagcttgtgc cgggattgta
    11101 tttctgcggg gaactattgg atctggatgc gatgaccggc ggatttaatc tgcagattgc
    11161 ctggtcgacc gggcatctgg cgggtgagag tatcgaatag aagaggagag aagaagagat
    11221 gagtatgaat attgcgattg acggaccggc aggcgccggg aagagcacaa ttgcgaaaaa
    11281 actggcgaaa aagctggcgt ttgtctatgt ggatacggga gcaatgtacc gtgcgatggc
    11341 atactatttt ttacagaacg gcattgcacc agatgatgag caggcgattg cggcagcctg
    11401 cccgaaggtt gacgtgacga ttgtgtatga gaacggcgaa cagcaggtgc tcttaaacgg
    11461 agagaatgta aacggcgtca tccggacgga ggaagtcggc aatatggcat cagcgaccag
    11521 tgtctatccg gttgtgcgca caaagcttgt ggaactgcag cggcagcttg cgacaaagac
    11581 ggacgtcatc atggacggaa gggatatcgg cacctgtgtg cttccagatg cgcaggtaaa
    11641 aatatatctc acggcaagtg ttgcgacgcg cgcaaagcgc agatatgatg aactgaccgc
    11701 caagggaacc cagtgcaatc tggaagagat cgagaaagat attgaagacc gcgattaccg
    11761 cgatatgcac cgggagacgt cgccgttaaa gcaggccaag gatgcggtgt tagtggacag
    11821 ctccgagatg aacatcgacg aagtggtgga cgcaatctat cagatttatg cgagggtata
    11881 gagaatatga atgtaatctt ggcaaagagt gcgggcttct gcttcggggt aaaacgtgcc
    11941 gtggatacgg tatatgaacg gattctggaa aaagaaccgc tctacacgtt cggaccgatc
    12001 atccacaatg aagaagtggt gcgcgatctg gaggaaaagg gcgtcgtcgt ggtaaacgat
    12061 gtggacgaac ttgcggggaa gccgcagggg acggtaatca tccgggcaca cggcgtggag
    12121 agaggtgtct gcgagaaaat acagacgctc ggtttttcca tcgtggacgc gacctgcccg
    12181 tttgtgttaa agattcaccg gctggtggag cgctacagtg gggaggactg tcacattgtg
    12241 atcgtcggga atgccagcca cccggaggtg aaaggcatca aaagctggtc gaatgcagag
    12301 gatacgcgcg tgatcggaac ccgcgaagag gccgaaaaat acgatgcttc ccatggaaaa
    12361 aaggtatgta ttgtatcaca aacgacattt aattacaata aatttcaaga attagttgaa
    12421 attataaaag aaaaaggtta tgatataatt gttttaaata caatctgcaa tgctacggag
    12481 gaacgtcaga cggaagcccg ggcaatcgcg gagcaggtgg atgccatgat tgtgatcggt
    12541 ggcaggaaca gctccaacac gcagaagcta tttgaaatat gtaaaaacga atgcaaaaat
    12601 acttactata tacaaactgt aaaggatctt gaccttgccg aagtcaggtc tgtcgataac
    12661 gtaggtatta ccgcaggggc ttctacccca aacaatatta ttgaggaggt tcaaaagaat
    12721 gtcagaaatg agttttgaac aaatgctgga tgaatcattt aaaacaatca ga
//
