LOCUS       c00020_gnlPro..        14079 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|CIGIMPGA_20.
ACCESSION   c00020_gnlPro..
VERSION     c00020_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 01:28:14
            Original ID  :: gnl|Prokka|CIGIMPGA_20
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14079
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14079
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[5157:12293]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      5158..12293
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..14079
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14079
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             complement(199..930)
                     /locus_tag="ctg20_1"
                     /transl_table=11
                     /translation="MNDTAAAILKATAALRDGTEKLRFESPVHVTYNPLTYAWGPHEQY
                     VRTYGNGEKGHLFLGMNPGPFGMAQTGVPFGEVDAVVNWLHIRGEVGRPEHTHPKRPVE
                     GFGCPRSEVSGRRLWGLFAEAFGTAENFFRHNYVANYCPLIWMGATGANITPDKLPAEQ
                     RAAVDAVCMEHLLSLITILNPHTLVGVGAYATQKLRDAASRLPGKSFTIGTLLHPSPAS
                     PIANKLWPERPIQQLKELGIL"
     CDS             1059..2003
                     /locus_tag="ctg20_2"
                     /transl_table=11
                     /translation="MTSGGDAAGMNPAIKAAVDHARQLGMNPYVVYDGLEGLIDGKIKE
                     ATRELTNDMIYRGGTLLRSSRSKRFFDYEFRKQAYEHLKKRNIDKLIIMGGDGSFRALN
                     DFFNDFEVPFAGIPATIDNDIAGTDYCLGVDTAQNVILDCIDSVRDTARSHHRAFVIET
                     MGRDCGYLAMTTALCSAADICIVPEIPYDLESIYKRLQPVINEEGSCIIAVVAEGTRVA
                     QYLTRWLTERAGMDTRLTVLGHVQRGGSPTARDRLMGTRFATRAVEALNNGDINQIMVY
                     HDGQYGYASLDSVAGQQYSVNQDIINLCRELSC"
     CDS             2135..3187
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GDP_Man_Dehyd"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg20_3"
                     /sec_met_domain="GDP_Man_Dehyd (E-value: 9.5e-98, bitscore:
                     317.3, seeds: 258, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKVIVTGGAGFIGSNLVRLLLERGHEVLNIDALTYAGNIHSLDGS
                     ADSPAYLFLHADVRDASLMRRTLREYAPDWVMHLAAESHVDRSIDDPGNFMTTNVMGTF
                     SMLQSALEYYRSLEGEKKERFRFHHISTDEVYGSLGKEGLFTESTPYRPHSPYSASKAS
                     SDHLVRAWHDTYGLPVLITNCSNNYGPYQFPEKLIPVVILKALGGAPIPVYGKGENVRD
                     WLYVGDHCEALLTVVSCGKPGETYNIGGNNEKTNLELVELLCSHLDELRPRPDGRSYRE
                     QISFVQDRPGHDLRYAIDASKIRRELGWTPRQDHSSGFRKTIQWYLDHEEWWRGILSGE
                     YRLERLGTNG"
     CDS             3197..4060
                     /locus_tag="ctg20_4"
                     /transl_table=11
                     /translation="MKGIVLAGGSGTRLHPVTLSVSKQLLPVYDKPMVYYPISVLMLAG
                     IREILVISTPRDLPLYRDLLGDGSRFGVSFEYREQPRPEGLAQAFIIGEEFIGKDSVAL
                     VLGDNIFYGRGLTEKLRRAAELTSGATIFGYQVHDPQRFGVVEFNEEGKAVSIEEKPLR
                     PKSDIAVTGLYFYDNRVVEIAKRIPKSSRGELEITSVNQEYLKQGLLRVEKLARGYTWL
                     DTGTHDTLLEASMFVRTLEHHQGFKVACLEEIAFNNGWISQETLRSQAGAMNNNGYGRY
                     LDELVK"
     CDS             complement(4338..5039)
                     /locus_tag="ctg20_5"
                     /transl_table=11
                     /translation="MNWMIYPAARAFIKVCAVLFGAGATAAALIHLFMPFFLRSPRTAA
                     PFLLLGTGAELLSILSLSFLMFWGARVLLASRGSKITRNLSMLAFLPALYALLIPFAGM
                     PASSQYTEMDRVWEAFLLLASVISFFSFPYTAGYGAAGRRLFLAWGISAAGCGLQSALF
                     FLAVLLRQFLTTAVPSLAAPVAWLAVLLSCGLEIMLAALSVILARRLFKEVMSIASMPE
                     SIDPSMPGNLP"
     CDS             complement(5158..6654)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: AcetylCoA_hydro"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: AcetylCoA_hyd_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg20_6"
                     /sec_met_domain="AcetylCoA_hyd_C (E-value: 7.3e-47,
                     bitscore: 148.9, seeds: 181, tool: rule-based-clusters)"
                     /sec_met_domain="AcetylCoA_hydro (E-value: 5.2e-44,
                     bitscore: 140.4, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSYKVLTPEEAASLIKHGHHIGLSGFTPAGTAKAVTAALAKIAEA
                     EHEKGNPFQVSVFTGASTGDSCDGILSRAKAIRYRAPYTTNVDFRKAVNNGEIAYNDIH
                     LSQMAQEVRYGFMGNVDIAIIEACEVTADGKIYLTAAGGIAPTICRLADKIIVELNAAH
                     SKSAMGLHDVYEPLDPPYRREISIFKPSDRIGKPYIQVDPKKIVGVVETNWPDEARSFA
                     AADPLTDKIGQNVADFLAADMKRGIIPSTFLPLQSGVGNIANAVLGALGRDKTIPAFEM
                     YTEVIQNSVIGLIREGRVKFGSACSLTVTNDCLEGIYRDMDFFRDKLVLRPSEISNSPE
                     VIRRLGVISINTAIEADIYGNVNSTHIGGTKMMNGIGGSGDFTRNAYISIFTCPSVAKD
                     GKISAIVPMVSHHDHTEHDVNIIITEQGVADLRGKSPKERAQTIIENCVHPDYKNILWD
                     YLKLSDGKAQTPQSIRAALGMHAELARSGDMKNVDWAQYK"
     CDS             complement(6716..7495)
                     /locus_tag="ctg20_7"
                     /transl_table=11
                     /translation="MNSAASFSTPPEEEGPCGDWTYHEWAEAFSTNDLARSLPPGHIAV
                     CRVQTGGRGRFNRKWIGEEGGLWASFTVPLSAPADTAAGVHWGHLPLVAGLALFNMLRG
                     MGLDSVRLRWPNDLLAGKSKLAGILVERPAENMAVIGIGINVFNDVASIAGEIKDPPAR
                     LADLVRDCPSLHAVMASLGSHLNQVLSVFSHGGVSALQEGLSRAWAGERPVSILTDDET
                     VRGIFTGIDDQGNPVLSLPAGAVRTIPAHLINRLLEE"
     CDS             complement(7533..9158)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg20_8"
                     /sec_met_domain="OAD_beta (E-value: 8.6e-160, bitscore:
                     521.1, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGVFSLSWQMVGMWGIAILLLYLGVAKQYEPLLMVPIAFGALIAN
                     IPDNGMLITQLNQQVISSNEQGEVTSTSLNNVGYLRVHVAPLQQTPAKVPANLTTPEAR
                     AQYLETMQQPMQVYPGSQLTVSKIKSVRESQEKAKADAARLGDDSLTVDPNLKDFQNVT
                     EDNGNEPVFLLTNGEGTTVVRQQGVNYFDTSGNRVPVDLKTQKLEPLVVSAAGKYVAVG
                     QHTQELLVTSIHGGLYDWIGLGIKAEIFPPIIFLGVGALTDFGPLLAAPRTLLLGAAAQ
                     VGVAATFFMALFMGFNPNEAASIGIIGGADGPTSIFLTMKLAPHLLGAVAVAAYTYMSL
                     VPLIQPPIMALLTTKKERLIRMKSLRTVSKSEKLFFAVLVTIVTILLIPDASPLIGMLM
                     LGNFLRECKVTERLVQASQNEIINIVTIFLGTSVGLTMQGDRFLQAETLLIILLGIVAF
                     GVATAGGVIAAKLMNLIWRKNPVNPLIGSAGVSAVPMAARVSHNVGQKYDPSNYLLMHA
                     MGPNVAGVIGTAVIAGYYIATLAK"
     CDS             complement(9276..9683)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 58.7; E-value:
                     1.3e-18)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg20_9"
                     /sec_met_domain="Biotin_lipoyl (E-value: 2.7e-19, bitscore:
                     58.7, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKLRITVDGKVFDVSVELLDQVSSTTAAPAPAPVAAPAPAASAP
                     VATPAPAPAPAPAPAPAAAGAGDVPSPLAGKVVSLDVAAGAPVKAGDQILTLEAMKMNT
                     IIYAPASGTLTAFCVNPGDTVQEGQALAKIG"
     CDS             complement(9758..10204)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg20_10"
                     /sec_met_domain="OAD_gamma (E-value: 2.8e-11, bitscore:
                     33.8, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLLTTLAFAQGIANVMNNLNYQIVGIMVVMMCLGGLAVILTISGS
                     IAAAIQNRAKAKTAAPVAAPAAAPAAAGKPGMTPEMLAILSAAVDSAMTELTPEMVAVI
                     SAAVDAGLDGMSHRIVEIKQSPGSGYAAAGRAEIFASHRIRPSR"
     CDS             complement(10226..11791)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Vparvula"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg20_11"
                     /sec_met_domain="CT_Vparvula (E-value: 1.2e-216, bitscore:
                     709.8, seeds: 132, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAIDPKLIDDLNSRRKKVILSGGQEKIDKRHEKGEMTARDRMGYL
                     FEEGTFSEIGMHVRHNCHNFGMGKKEIPGDGVVSGFGLVDGRPVACAASDFLAQGGSLG
                     YMHAMKIADAQKYALKAGIPMVTVNDSGGARLQEGVAALSGYAQVFYNNVLASGVVPQI
                     SMILGPCAGGAAYSPALTDFIIMRNSGNAGMYITGPKVIEQVTYEKCTMDDIGSAAIHA
                     TVSGNVHFVADSDAHAMDILKRLLSFLPSNNTEEPPHKLDTPLDLSADEGMSDLIPGDN
                     RTPLDVQPIISRLVDNGDFLEVHKDFAKNVVVGFGRICGVVVGIIANQPNVKAGCLDID
                     SSDKAARFIRFCNAFNIPLVNLVDVPGFLPGKNQERGGIIRHGAKLIFAYSQATVPKVT
                     LIMRKAYGGAYIAMCCKDLGADAVFAWPGAEIAVMGAEGAVPVLYGRELKAVEDPAEKA
                     KRQGELLEEYREAFYNPYVAAGMGQITEVINPEETRAKIAFALRTLLNKKEVRPAKKHG
                     NIPL"
     CDS             complement(11823..12293)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Glyoxalase_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg20_12"
                     /sec_met_domain="Glyoxalase_4 (E-value: 9.4e-26, bitscore:
                     80.1, seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYCRPPPCIPYNHHTHMIQQIDHIGIAVKSLDATVPYYRDALGLG
                     EPHIEEVPTQKVRVAMFDVAGVHIELLEPTSPESAIAKAIEKKGEGIHHIAFKTNDIAG
                     NISQAKEAGLTVLNDPPVPGAHNTQVTFLHPKCTFGVLTEFCQHPGGCECGK"
     CDS             12411..13949
                     /locus_tag="ctg20_13"
                     /transl_table=11
                     /translation="MFKSGLAVLFLLASWFSASCAYELLPAHVAVVYNGKSELSRRMAR
                     EYARVRGVPEGNLVSLDCPTTSEISRKEYEDTIRVPLLEAARKQRWWVPSGIASSPLMN
                     RKIFVLVLMADLPMKIRHETPAPLPGKGVNQMQTDRAAVDSELALLAVGGYERKSWQVN
                     PYFNKREDFVGSGLPSFLVCRLDGLTPDTCMRLVAEPANVEKKGLWGWAVVDRGGPYAQ
                     GDRWLDDVFERVREAGIPAYLDDWPQTLPEKFPLSRDTALYCGWYAGNANGPFSDPSFR
                     FRPGAIAMHLHSFSAADFKVPGRGWSSALLEKGAAVTVGNVYEPFLGACHRFDIFVDRL
                     LDGYTVAEASWMSMPVLSWQGLVFGDPLYRPYARMKDMDVEPTEEDRYFQGWWASSVQF
                     GDRWKDRSARLMESARKAPFSCLYEALALECLYRKEPARAGELLSSALDGAADARTRAR
                     LLLEILMAERARGGNKAFLQRADGIRGLMSSSAFLPALEEWLARVAPPPDPPEK"
ORIGIN
        1 cccggtagat gccggcgtgc atttcttccg tcaggaaggc cgtgtccctg ggcgaatcaa
       61 gccagtgaag ggggccggat attccttcaa agcgatgtag ttttggaggg gaacaagatg
      121 aactgccgat ttccggcctg tcgctctggt gattccttcc atgtcacgga gctttccact
      181 ctacctcctc cgctcttttt ataaaatgcc cagttcctta agctgctgga tggggcgttc
      241 cggccagagc ttgttggcga tggggctggc ggggcttggg tggagcaacg tgccgatggt
      301 gaagcttttg ccggggagcc gggaggcggc gtcccgcagc ttctgcgtgg cgtaggcacc
      361 cacacccacc agcgtgtggg gattcaggat ggtgatgagg gaaagcaggt gttccatgca
      421 tactgcgtcc acggcggcgc gctgttccgc cggcagtttg tccggcgtaa tgttggctcc
      481 ggtggctccc atccagatca gcggacagta attggccacg taattgtgac ggaagaagtt
      541 ttccgcagtg ccgaaagctt ccgcgaaaag tccccagagg cggcggccgc tgacttccga
      601 cctggggcag ccgaaaccct ccacgggacg tttggggtgg gtatgttccg gccgtccgac
      661 ttctccgcgg atgtgcagcc agttgacgac ggcgtccact tccccgaaag ggacgcctgt
      721 ctgggccatg ccgaaggggc cgggattcat gcccaggaac agatggccct tttccccgtt
      781 tccgtaggtg cgcacatact gttcatgcgg cccccatgca taggtgagag ggttgtaggt
      841 aacatggacc ggggattcga accggagctt ctccgtgccg tcccggaggg cggccgtggc
      901 tttcagaatg gctgctgcag tgtcgttcat gcctccgcat catgaagtgt tgccgtttat
      961 tgcgccagta aaaactccgc gcttgcatta tttgttccgc ccggtaacat ttccccccgg
     1021 acaagttaac cttattactt atgagtggaa tagccattat gacatctggc ggtgatgccg
     1081 ccggaatgaa cccggcgatc aaggcggcag tggatcatgc ccgccagctt gggatgaacc
     1141 cgtacgttgt ttatgacggc ttggaagggc tgatcgatgg aaaaatcaag gaagccaccc
     1201 gggaactgac caacgatatg atctacaggg gcggaactct cctccgttcc tcacgatcca
     1261 agcgcttttt cgactacgaa ttccgcaagc aggcctacga acatctgaag aaacgcaaca
     1321 tcgacaagct catcatcatg ggcggggacg gttccttccg cgccctgaac gactttttca
     1381 atgattttga agtgcctttt gccggtattc cggccacgat tgacaacgac attgccggca
     1441 cggactactg cctgggcgtg gatacggccc agaacgtgat tctggattgc attgattccg
     1501 ttcgtgatac ggcccgttcc catcaccgcg ctttcgtgat tgaaacgatg ggccgggact
     1561 gcggctatct ggcgatgacc accgctcttt gcagcgcggc ggatatctgc attgtccctg
     1621 aaattccgta tgacctggaa tccatttaca agcgcctcca gcctgtcatc aatgaggaag
     1681 gaagctgcat cattgccgtg gtggcggaag gcacccgcgt ggcgcagtac ctgacccgct
     1741 ggctgacgga acgcgccggc atggataccc gcctgaccgt gctgggccat gtgcagcgcg
     1801 gcggttcccc caccgcccgt gaccgcctga tgggcacccg ttttgccacc cgcgccgtgg
     1861 aagctctgaa caacggggac atcaaccaga tcatggtgta tcatgacggc cagtacggct
     1921 atgcctccct ggattccgta gccgggcagc agtactccgt gaaccaggat atcatcaacc
     1981 tttgtcggga gctgagctgc tagccgtctc agcggttacg gaacccgctt tttcccgccc
     2041 atgccgccac gttcccgcgg catgggcgga tttgttttga aaaaaaacgc cgctgctgta
     2101 tgatggcgcc gcatctttcc ctgaaaacag tgctatgaaa gttatcgtta cgggcggcgc
     2161 cggattcatc ggctccaatc tggtcaggct gctgctggag cgcggccatg aagtcctgaa
     2221 tattgacgcc ctgacctatg ccggcaacat ccattcactg gacggctcgg cggattctcc
     2281 ggcatacctc tttctgcacg ccgacgtccg ggacgcttcc ctgatgcggc gcactttgcg
     2341 ggagtacgct ccggactggg tgatgcacct ggcggcggaa tcccatgtgg accgttccat
     2401 tgacgatccg ggaaatttta tgaccaccaa cgtcatgggc actttttcca tgcttcagtc
     2461 cgccctggaa tattaccgtt ccctggaggg agagaaaaag gagcgtttcc gcttccacca
     2521 catttccacg gatgaagtgt acggctccct gggaaaggaa ggcctgttca cggagtccac
     2581 gccgtatcgc ccccattccc cgtattccgc cagcaaggcc tccagcgacc acctggtgcg
     2641 cgcctggcac gatacgtacg gactgcccgt gctgatcacc aactgttcca acaattacgg
     2701 cccttaccag ttcccggaaa agctgatccc cgtcgttatc ctgaaagcgc tgggcggggc
     2761 ccccatccct gtatacggca aaggggaaaa cgtgagggac tggctgtatg tgggggatca
     2821 ctgcgaggct ctgttgacgg tcgtttcctg cggaaaaccg ggggaaacgt acaacatcgg
     2881 cggcaataac gagaaaacca atctggagct ggtggagctg ctgtgttccc atctggatga
     2941 actgcggccc cggccggacg gccggagcta ccgggagcaa atctcctttg tgcaggacag
     3001 gccgggtcat gacctgcgct atgcgattga cgcttccaaa atacggaggg aattggggtg
     3061 gactccgcgc caggaccatt cttccggatt cagaaagacc attcagtggt atctggacca
     3121 tgaggaatgg tggcggggca tcctgtccgg ggaataccgc ctggaacgtc ttggaaccaa
     3181 tggctaggaa tttgatatga agggtattgt tctggccggg ggaagcggca cgcgtctgca
     3241 tcccgttacg ctttccgtca gcaagcaatt gctgcccgtt tatgataagc cgatggttta
     3301 ttatcccatc tctgtgctga tgctggccgg aatacgggaa atccttgtta tttccacgcc
     3361 ccgggatctg cccctgtacc gggatttgct gggggacggc agcaggttcg gcgtttcctt
     3421 tgaatacagg gaacaaccca ggccggaggg gctggctcag gcctttatta ttggagagga
     3481 gttcatagga aaggattccg ttgccctggt gctgggggac aatatttttt acgggcgcgg
     3541 cctgacggag aagctgaggc gggccgccga actgacgagc ggagcgacca ttttcggtta
     3601 ccaggtgcat gacccgcagc gtttcggggt agtggaattc aatgaggagg ggaaggcggt
     3661 ttccattgag gaaaaaccgc tcaggcccaa atcggatatt gcggtgacgg gcctctattt
     3721 ttacgacaac cgggtggtgg agatagccaa acggattccc aagtcttccc gcggcgagtt
     3781 ggaaatcacc tctgtgaatc aggaatacct gaagcagggc ctgttgcgcg tggaaaaact
     3841 ggcgcgcggt tatacgtggc tggatacggg cacgcacgat acccttctgg aggcttccat
     3901 gttcgttcgt actctggagc accaccaggg gttcaaggta gcctgcctgg aggagatagc
     3961 ctttaataac ggctggattt cccaggaaac gctgcgctcc caggccggag ccatgaataa
     4021 taacggttat ggccgttatc tggatgaatt ggtgaaatag ggctgtctgc cgccggcgtg
     4081 gaaacgggag gggtgttcct gcgaacccgc ggctttccgg ggtggggcgg gttgctttcc
     4141 ggcaatgctt tccatacgga ttccgttcca ccggcggaaa tttccggacg gctttttgcg
     4201 caaagccgta aaagcctttc atgccgggat gcggcagccg ggttggaaga aggctgccgt
     4261 gagcggttcg cgtattcatg ccgcggactg ggggtaaccc cttccaactg gctgcaaaca
     4321 tgaaggcagg ggggaagtca gggaaggttg cccggcatgg agggatcaat cgattccggc
     4381 atggacgcta tggacatgac ctctttaaac aggcgccgcg ccagaatgac ggaaagggcc
     4441 gccagcatga tttccaggcc gcaggacaaa agaacggcca gccatgcaac tggcgctgcc
     4501 agggagggaa ctgctgtggt caggaattga cgcaacagga cggcaagaaa aaacagggcg
     4561 ctctgcaaac cgcatcctgc cgccgagatg ccccaggcca ggaataatct cctgcctgcg
     4621 gcgccgtatc ccgccgtata agggaaggaa aagaaagaaa tgacggacgc cagaaggagg
     4681 aaggcctccc aaaccctgtc catttccgta tattgcgatg aggcgggcat gcccgcaaac
     4741 ggaatgagga gggcgtacag ggcgggcagg aaggccagca tgctcagatt tcttgttatc
     4801 ttgcttcccc gggaggccag cagaactctg gcgccccaga acatgaggaa ggacagggaa
     4861 aggatggaga gcaattccgc ccctgttccc aaaagcagga agggcgcggc tgtccgggga
     4921 gagcggagga aaaaaggcat gaacagatgg atgagggctg ctgctgttgc gcccgcgccg
     4981 aaaagaacgg cgcagacttt gatgaaagcc ctggctgccg ggtaaatcat ccagttcatg
     5041 gtgaagaaaa ggagtagagg ggatgggaaa aaggaaaagg accgctccct ttgcggaagc
     5101 ggtcctgagg ggttaacgtg aattcatgga tgccaatgcg agtgacggca tgcggaatta
     5161 cttatactgg gcccagtcga cattcttcat gtctccgctt ctggccagtt cggcgtgcat
     5221 gcccaaagcg gccctgatgg attgcggcgt ctgggctttg ccgtcggaca gcttcaggta
     5281 atcccagagg atgtttttgt aatccgggtg gacgcagttt tcaataatgg tctgggcccg
     5341 ttctttcggg ctcttgccgc gcaggtccgc gaccccctgc tcggtaataa tgatattgac
     5401 gtcatgttcc gtatggtcat ggtgggaaac catggggacg atggcgctga tcttgccgtc
     5461 cttggcaacg gacgggcagg tgaaaatgga gatgtaggcg ttgcgcgtga agtcgccgga
     5521 cccgccgatg ccgttcatca tcttcgtgcc gccaatgtgc gtggagttga cgttcccgta
     5581 aatgtcggct tcaatggcgg tgttgatgga gatgacgccg agacggcgga taacttccgg
     5641 gctgttggat atttccgagg gacggagcac cagtttgtcg cggaaaaagt ccatatccct
     5701 gtaaatgcct tccaggcagt cgttcgtcac ggtcagggag caggcgctgc cgaatttcac
     5761 gcggccttcc cgaatcaggc cgatgacgga gttctggatg acttccgtgt acatctcgaa
     5821 cgcgggaatc gtcttgtcgc ggcccagggc gcccagcacc gcgtttgcga tgttgcctac
     5881 gccggactgg agaggcagga atgtggaggg aatgatgccc cgtttcatgt cggcagccag
     5941 gaaatcggcc acgttctgcc cgattttatc agtcagggga tccgctgcgg cgaaggaacg
     6001 ggcttcatcc ggccagttgg tttccacaac gcccacaatc tttttcgggt caacctggat
     6061 gtacggcttg ccgatgcggt cgctgggttt gaagatggag atttcgcggc ggtagggagg
     6121 atccaggggt tcgtaaacgt cgtgcaggcc catggcgctc ttgctgtggg cggcgtttaa
     6181 ttccacgata attttgtctg ccaggcggca gatggtggga gcgatcccgc ccgcggccgt
     6241 caggtaaatt ttgccgtcgg ccgtgacttc acaggcttca ataatggcga tgtccacgtt
     6301 gcccatgaac ccgtagcgca cttcctgggc catctgggac aaatggatgt cattataggc
     6361 gatttccccg ttgttcaccg ccttgcggaa atcaacgttg gtggtgtagg gagcgcggta
     6421 gcggattgcc ttggcccggg aaaggatccc gtcgcaggaa tcgccggtgg aagcaccggt
     6481 gaagacgctc acctggaaag ggttcccctt ctcatgttcc gcttctgcga tttttgccag
     6541 cgcggccgta acggccttgg ccgttccggc gggcgtgaat ccgctcagcc caatatggtg
     6601 gccatgcttg atcaggcttg ctgcttcttc tggtgtcagt accttgtaac tcatgtcagt
     6661 gatttttgtt ggatgaaaaa agaaagaaac cccgtgtaaa aacggagcgg caggctcatt
     6721 cttcgaggag cctgttaatc aggtgcgccg gaatggtgcg gacggcgccg gccggaaggg
     6781 atagcacagg attgccctga tcgtcaatcc ctgtaaaaat accccggacg gtttcgtcat
     6841 ccgtaagaat ggaaaccggc ctttctccgg cccatgcccg ggacagaccc tcctgaaggg
     6901 cagagacgcc gccgtgggaa aagacggaaa gaacctggtt caaatgactg cccagggaag
     6961 ccatgacggc gtgcagggaa gggcagtccc gaacaagatc cgccagcctt gccggagggt
     7021 ccttgatttc cccggcgatg gaggctacat cattgaaaac attgatgccg atgccgatga
     7081 cggccatgtt ttccgccggg cgttccacca gtattcccgc cagtttggat ttgcccgcca
     7141 gcaggtcgtt cggccagcgc aggcgcacgg aatccagccc catgccgcgg agcatgttga
     7201 acagggccag ccccgcaacc aggggcaaat ggccccagtg cacgccggcc gctgtatccg
     7261 caggagcgga caggggaacg gtgaaggatg cccacaggcc gccttcctcc cctatccatt
     7321 tgcggttgaa cctgccgcgg cctcctgtct gaacgcggca gacggcaata tgccccgggg
     7381 gcagggagcg ggccaggtca ttggtggaaa aagcctcggc ccattcatga taagtccagt
     7441 cgccgcatgg tccttcctcc tccggagggg tggaaaatga ggctgcggaa ttcatgggac
     7501 gggccgaggc cgggagtaat tttcaattct ggttatttcg ccagagtggc gatgtagtag
     7561 cccgcgatga ctgcggtgcc gatcacgcct gcaacgttcg ggcccatggc gtgcatgagc
     7621 agatagttgg aggggtcgta cttctggccc acattgtggg agacgcgggc cgccatcggg
     7681 acggcggaga cgcctgcgga cccgatgagg gggttgaccg gattcttgcg ccagatgagg
     7741 ttcatgagct tggcggcgat gacgccgccc gcagtggcta cgccgaaggc gacaatgccc
     7801 agcagaatga ttagcagcgt ttccgcctgc aggaagcggt ctccctgcat cgtgagaccc
     7861 acggaggttc ccaggaagat ggtgacgatg ttgatgattt cattctggga ggcctgaacc
     7921 aggcgttccg tcaccttgca ttcgcgcagg aagttgccga gcatcagcat gccgatgagc
     7981 ggggatgcgt ccggaatcag cagaatggtg acaatggtta ccagcacggc gaagaacagt
     8041 ttttcgctct tgctgaccgt ccgcagggat ttcatgcgga tgaggcgctc cttcttggtc
     8101 gtcagcaacg ccatgatggg cggctgtatc agcggaacca gggacatgta cgtgtatgcg
     8161 gccacggcca cggcgcccag caggtgcgga gccagcttca tcgtcaggaa gatggaagtg
     8221 gggccgtcag ctccgccgat gatgccgatg gaggcggctt cattcgggtt gaagcccatg
     8281 aacagggcca tgaagaacgt ggcggctacg cccacctggg ccgccgcgcc cagaagcagg
     8341 gtgcgcggtg cggcgagcag cgggccgaag tccgtcaggg ctcctacgcc caggaagatg
     8401 atgggcggga aaatttcagc cttgatgccc agcccgatcc agtcatacag gcccccgtgg
     8461 atggaggtga ccagcagttc ctgggtatgt tggcctacgg ccacgtattt gcctgcggcg
     8521 gaaaccacca ggggttccag cttctgcgtt ttcaggtcca cgggaacacg gttgccgctg
     8581 gtgtcaaagt aattgacgcc ctgctggcgg acgacggtgg ttccttctcc gttcgtgagt
     8641 aggaagaccg gctcattgcc gttgtcctcc gtcacgttct ggaagtcctt caggttggga
     8701 tccaccgtca gactgtcgtc tcccaggcgg gcggcgtcag ctttggcttt ttcctgggat
     8761 tcccgcacgg acttgatttt ggaaacggtc agctggctgc cgggataaac ctgcatgggc
     8821 tgctgcatgg tttccagata ctgggcgcgg gcttccggcg tggtcagatt ggccggcacc
     8881 ttggcgggcg tctgctgcag aggagccaca tgaacgcgca ggtagcccac gttgttcagg
     8941 gacgtggagg ttacttcccc ctgttcattg gaggagatga cctgctggtt cagctgggtg
     9001 atgagcattc cgttgtccgg aatgttggcg atgagggcgc cgaaagcaat gggaaccatc
     9061 aggagcggtt cgtattgctt ggctacaccc agatacagga ggagaatggc aatgccccac
     9121 atccctacca tctgccatga tagggagaag acgcccatcc cctgtaaaaa ggtgattaat
     9181 gaatcaaaaa gactcatacg gaatgttatt gtagcggttt attatttgag ccggagcccg
     9241 ggactgttgg cgtttccggg ctgccgccgc cgggattaac caattttggc cagtgcctgt
     9301 ccttcctgaa ccgtgtcgcc cgggttcacg cagaaagcgg tgagcgtgcc ggaggcggga
     9361 gcgtagatga tggtgttcat cttcatggct tccagcgtca gaatctggtc accggccttc
     9421 acgggtgcgc ctgctgccac gtccagggag acgaccttcc cggcaagcgg gctgggaacg
     9481 tctcctgcgc cggcggcggc cggagcgggc gcaggtgcgg gagccggagc cggagccggg
     9541 gtggccacgg gtgcggatgc ggcaggagcg ggagcggcca caggtgcggg ggccggggct
     9601 gcggtagtgg aggatacctg gtccaggagt tctacggata cgtcaaatac cttgccgtct
     9661 acggtgatgc gaagtttctt catgataatg tatggtatgg agtattaagt taaatggttc
     9721 ccgccggggc gggggtaagg gtgaataatg ctgtagttca acgggaaggc cgaatgcggt
     9781 gggaggcgaa gatttccgcc ctgcctgcgg ccgcatagcc ggagcccggg gattgcttga
     9841 tttccacaat gcggtggctc atgccgtcca ggcccgcgtc cacggcggcg gagatgacgg
     9901 ccaccatttc cggcgtgagc tccgtcatgg cggagtccac cgctgcggag aggatggcga
     9961 gcatttccgg agtcatgccc ggtttgcccg ccgcagcggg ggcggcggca ggcgcggcca
    10021 cgggagcggc ggttttggct ttggccctgt tctgaatggc ggcggcgatg gagccgctga
    10081 tggtcagaat gacggccagg ccacccaggc acatcatgac caccataatg ccgacaatct
    10141 gatagttcag attgttcatg acgttggcga tgccctgtgc aaaggcgagt gttgtgagta
    10201 acatatgaat ccgttgagat ggatgttaga gcggaatgtt gccgtgtttc ttggccgggc
    10261 gcacttcctt cttgttcagc agggtgcgca gggcgaaggc gattttggcg cgggtttctt
    10321 ccggattgat gacttccgtg atctgtccca tgccggccgc cacatacggg ttgtagaagg
    10381 cttcccggta ttcttcaagg agttctccct gtcgcttggc tttttccgcc gggtcttcca
    10441 cagccttcaa ttcacggccg tagagcaccg gaacggcgcc ttccgcgccc atgacggcga
    10501 tttccgcgcc gggccaggcg aagacggcgt cagcgcccag gtccttgcag cacatggcga
    10561 tgtaggcgcc gccgtaggct ttccgcatga tcagggtgac tttgggcacc gtggcctggg
    10621 aataggcgaa gatgagtttg gcgccgtggc ggataatgcc gccccgttcc tggttcttgc
    10681 cgggtaggaa gccgggcacg tccaccaggt tcaccaacgg aatattgaac gcgttgcaga
    10741 agcggatgaa gcgcgcggcc ttgtcggagg agtcgatatc caggcagccg gctttcacgt
    10801 tgggctggtt ggcgatgatg ccgactacta cgccgcagat gcggccgaag ccgacgacga
    10861 cgtttttggc gaagtcctta tgcacttcca ggaagtcccc gttgtccacc aggcggctga
    10921 tgatgggctg gacgtccagc ggcgtgcggt tgtcgccggg aatcaggtcg ctcatacctt
    10981 cgtctgcgct caggtcaagc ggggtgtcca gtttgtgagg cggttcttcc gtgttgttgg
    11041 aaggaaggaa ggaaagcagc ctcttcagga tgtccatggc gtgcgcgtcg ctgtccgcta
    11101 cgaaatggac gttgccggat acggtggcgt gaatggcggc ggagccgatg tcatccatcg
    11161 tgcatttttc atacgtgacc tgttcaatca ccttggggcc ggtgatgtac atgccggcgt
    11221 tgccggaatt gcgcatgatg atgaagtccg tcagggcggg ggagtaggcc gcgccgcccg
    11281 cgcagggacc cagaatcatg gagatttgcg gaaccacgcc ggaggcaagc acattgttgt
    11341 agaacacctg ggcatagccg gaaagggccg ccacgccttc ctggaggcgc gcgccgccgg
    11401 agtcgttcac ggtcaccatc gggatgccgg ctttcagggc gtacttctgg gcatccgcaa
    11461 ttttcatggc gtgcatgtag ccgagggacc cgccctgggc caggaagtcg gaggccgcgc
    11521 aggccaccgg acggccgtcc accaggccga agccggaaac gacgccgtcg ccggggattt
    11581 ccttcttgcc catgccgaag ttgtggcagt tgtggcgcac atgcatgccg atttccgaga
    11641 aggtgccttc ctcaaagagg taccccatgc ggtcgcgggc tgtcatttcg cccttttcat
    11701 gtctcttgtc gatcttttcc tgaccgccgc tgaggattac cttcttgcgg cggctgttca
    11761 gatcgtcaat caatttggga tcaatagcca ttggtatagt ggtatggtga atagggagaa
    11821 tgttacttgc cgcattcgca gccgccgggg tgctggcaga attcggtcag gacgccgaag
    11881 gtgcacttgg gatgcaggaa ggtgacctgc gtgttgtgag cgccggggac gggcgggtcg
    11941 ttcagcacgg taaggcctgc ttccttggcc tgggagatat ttccggcgat gtcattggtc
    12001 ttgaaagcga tgtggtggat gccttcccct tttttctcaa tagccttggc gatagcgctt
    12061 tccggagagg tgggttcgag cagttcgatg tggactccgg caacgtcaaa catggcgacg
    12121 cggacctttt gagtgggaac ttcctcaatg tggggctctc cgagcccgag cgcatcgcgg
    12181 taatagggga cggtggcgtc aaggctcttg acggcgatgc cgatatggtc aatttgctga
    12241 atcatatgcg tgtgatggtt atagggaatg caggggggag gcctgcaata catcaagagt
    12301 tattaaagcg tattttttta ggatgtgaag cgaaaagcgg aaaaatggcg aattcgtggc
    12361 cgcccctttc acctgcttga ttgccccgga agatgaggta tggtaggggc atgttcaaga
    12421 gtggattagc cgtgttattt ctgctggcgt cgtggttttc cgcctcgtgt gcctatgagc
    12481 tgctgcccgc tcatgtggcc gtggtttata acggaaaatc cgagctgagc cgccgcatgg
    12541 ccagggagta tgcgcgggtg cgcggcgttc cggaagggaa tctcgtttcc ctggattgcc
    12601 ccacgaccag cgagatttcg cggaaggagt atgaggatac gatccgcgtc ccgctgctgg
    12661 aggcggcgcg gaaacaacgg tggtgggtgc cttccggcat tgcgtcctcc cccttgatga
    12721 accggaagat ttttgtgctg gtgctgatgg cggacctgcc gatgaagata cggcatgaaa
    12781 cgcccgctcc ccttcccggg aaaggcgtca accagatgca gacggatcgc gctgcggtgg
    12841 attccgaatt ggctctgctg gcggtgggcg gttatgaaag gaagtcctgg caggtgaatc
    12901 cctattttaa taaaagggag gattttgtgg gttccggcct tccttcgttt ctggtatgcc
    12961 gcctggacgg actgacgccc gatacctgca tgcggctggt ggcggaaccg gcgaacgtgg
    13021 agaaaaaagg tttatggggg tgggccgttg tggaccgggg cggcccctat gcccaggggg
    13081 accggtggct ggacgacgtg ttcgagcgcg taagggaggc gggcattccc gcttatctgg
    13141 atgactggcc ccagaccctg ccggaaaaat tccccttgag ccgggatacg gctctttact
    13201 gcgggtggta tgcggggaat gcgaacggac cgttttcgga tccttcgttc cgcttccggc
    13261 ccggggcgat agccatgcat ctgcattcct tcagcgccgc cgatttcaag gtccccggca
    13321 ggggatggag ttccgccctg ctggagaagg gggctgctgt gacggtggga aacgtgtatg
    13381 agccgttcct gggcgcctgc caccgctttg atatttttgt ggaccgcctc ctggacggct
    13441 ataccgtggc ggaggcttcc tggatgagca tgcctgtgct gtcctggcag gggttggtgt
    13501 tcggagaccc cctgtaccgt ccatacgccc gcatgaagga tatggacgtg gagccgacgg
    13561 aagaagaccg ttatttccag gggtggtggg cttcctccgt gcagttcgga gaccgctgga
    13621 aggaccgttc cgcgcgtttg atggagtccg cccggaaggc ccctttttcc tgcctttatg
    13681 aagctctggc gctggaatgc ctgtaccgga aggaaccggc ccgcgccgga gagctccttt
    13741 cctccgccct ggacggcgcg gctgacgccc gcacccgtgc gcgcctgctg ctggaaatcc
    13801 tgatggcgga acgggcccgg ggcggcaaca aggcttttct gcagcgggcg gacggcatcc
    13861 ggggcctcat gtcttcctcc gcttttcttc cggcgctgga ggaatggctt gccagggtgg
    13921 ctccgccgcc ggacccgccg gaaaaataaa ttaaggacgt acggcaaatt tggattgcct
    13981 tttaggggat tatggctcat attctgcgtc ccgtaagttt tccttttact gatattcacc
    14041 agcaatagat aacacaagat gaacattatc aacaaaatc
//
