LOCUS       c00022_gnlPro..        13661 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|JJNGJEDH_22.
ACCESSION   c00022_gnlPro..
VERSION     c00022_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 03:16:20
            Original ID  :: gnl|Prokka|JJNGJEDH_22
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13661
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13661
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1:3661](+)"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      2..3661
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
     cand_cluster    1..13661
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /kind="single"
                     /product="Others_HGD_unassigned"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13661
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Others_HGD_unassigned"
                     /region_number="1"
                     /rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D, HleuD1,
                     HleuD2, HleuS1, HleuS2, Lactoyl-CoA1, Lactoyl-CoA2]) and
                     minimum(1, [ACP_syn_III, ACP_syn_III_C, AcetylCoA_hyd_C,
                     AcetylCoA_hydro, Acyl-CoA_dh_1, Acyl-CoA_dh_2,
                     AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG, Biotin_lipoyl,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_6_Glutaconate, CoA_transf_3, ECH_1, ECH_2, ETF,
                     ETF_alpha, FGGY_C, HCDH, HCDH_N, Hacid_dh, Hacid_dh_C,
                     Mal_decarbox_Al, Peptidase_M22, Peptidase_M23, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and not (minimum(2,
                     [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /tool="gutsmash"
     CDS             2..3661
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: HGD-D"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: BcrAD_BadFG"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg22_1"
                     /sec_met_domain="HGD-D (E-value: 1.3e-22, bitscore: 72.3,
                     seeds: 370, tool: rule-based-clusters)"
                     /sec_met_domain="BcrAD_BadFG (E-value: 1e-33, bitscore:
                     108.4, seeds: 18, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="ENIAASIFHAVAVQTTVTLARGCNIVAPVLLCGGPLTFIPALRKA
                     FANYLNLSQDTDFILPEKGNLIPAWGAALAENNEESIHLSNLIQVIENKLSVTSPFQSD
                     LSPIFDSEEEYRSWKKEKDQYKIQYASLRPGLQEATIGIDSGSTTTKIVVLDNNHRILY
                     SYYHDNNGNPIKTVENGLQKLYEECRRRGTTLRIKGGCSTGYGEDLIKAAFHMDAGIIE
                     TIAHYAAAKHISKEVSFILDIGGQDMKAIFVNDGVINRIEINEACSSGCGSFISTFAQS
                     LDYSVEDFAKAACFSQAPCDLGTRCTVFMNSKVKQVLREGASVADIAAGLSYSVVKNCL
                     YKVLQLKDTEILGDHIVVQGGTMRNDSIVRSLEKLTGKQTFRSNCPELMGALGCALYAK
                     QIENARVTELNEMLQWAQYTSKQLQCRGCENQCAIMRYTFNNDNHYFSGNRCEKVFSNK
                     GSHADKGINTYDKKLELLFDRSADIPQPLFTIGIPRILNMYEEYPFWHTLFTACGIQVQ
                     LSAPSTFSKYETAAGMVMSDNICFPAKLVHSHIRNLTLQNVNRIFMPFVVFEKKDKQQQ
                     NSYNCPIVSGYSEVIKSVQEENIPIDAPTITFKDEALLYKQCYEYLKSLGIRDEVCKNA
                     FSRALQEQYAFEEKIAAYNQEVLNEGREKHKLIILLAGRPYHSDPLIQHKVSDMIAAMG
                     VYVITDDIVRQQEISLEKTHYLSQWAFTNRILKATKWAAMQEGDIQYMQMTSFGCGPDA
                     FLIDEVRNLLKRYGKNLTLLKIDDVNNIGSIKLRVRSLVESLNFSLKHSQAKDPEPFVS
                     TAPFTKKDKKKKILAPFFTPFISPLIPSIMKVAGYEMETLPLSDTASCDWGLKYSNNEV
                     CYPATLIVGDIVKAFKSGRYDPANTCVAITQTGGQCRASNYISLIKKALIENGYTNTPV
                     VSLAFGSGIENEQSGFKVNWLKVLPIILASVLYSDCIAKFYYAAVVREKERGQAARLRD
                     LYLDTAQPIIQKNKPEDLLSYLYLAARDFNKICEQRSCHKVGIVGEIFLKFNPFAQKDV
                     TSWLINQKIEVIPPLISDFFMQGFVNLKVRQNQHLQRKLTPDFVIDWLYKKVQKQINKV
                     NEIGKNFNYFTPFESIFEKAEKAKQVISPGTQFGEGWLISGEILSFASQGVNHVISLQP
                     FGCIANHIVEKGIEKRIKSLCPQMNILSLDFDSSVSDVNITNRLLLFIDNINN"
     CDS             3666..4286
                     /locus_tag="ctg22_2"
                     /transl_table=11
                     /translation="MATTEHSDLEQQIIKTAQQLFIEKGFVETSMSDIAATVGINRPTL
                     HYYFRTKDKMFKAVFGSIVMSLMPKIQDIVKQDIPFMERLSMILDEYIELFTSNPCLPR
                     FICGEIQRDVNHLLATAKELQFGDALSQVKDSILTAMEDGKLKKVPIHIVFLTVYSLLS
                     YPFLAKNLIVSLFLEDEAAFADFLQEWKQNIINQLQNLLCYEE"
     CDS             complement(4476..4898)
                     /locus_tag="ctg22_3"
                     /transl_table=11
                     /translation="MMRDAEKTVGNMIDKLKTAFIGSIDGEGFPTIKAMLQPRKRKGIK
                     TIYLTTNTSSMRVAQYRENNHACIYFCDTRFFRGVMLRGTMDVLTDSASKEMIWQEGDT
                     MYYPEGVTDPDYCVLKFTAISGRFYSNFKSEDFVVE"
     CDS             complement(4991..5869)
                     /locus_tag="ctg22_4"
                     /transl_table=11
                     /translation="MKNSIPRYTFYKHKYGSELLVDVVELKYVKKFLAKSAVHTLNYYD
                     ITFITEGKGAFSVDNQTYEAIPRDVLFSKPGEIRNWDTHHITNGYALIFEEEFLSFLFK
                     DSLFVQHLSFFQIESSSSLLHLSDELYTRILETLHDIKMEIDSYQQGDVHVLRALLYEV
                     LMLLDRAYLKMTSIEEGRSREVSNNHVSKFMNLVATHAKEQHSVQYYADKLCITPNYLN
                     EMITSTMGISAKQYIQSKVMEEAKRLLVYTDFPIADIAFELCFSTVSYFIRSFRQHTGE
                     TPLLYRKVHKP"
     CDS             complement(5993..6541)
                     /locus_tag="ctg22_5"
                     /transl_table=11
                     /translation="MEAYLKKLCFEYQVDEREVKELLARMEMVYLDKGETIASATLPEQ
                     SLYIIVSGILHTYTTHEGEERTNRFFSAGDAVLCYNSSQYSIKTLTKCAAYYISEEEIE
                     ELCASSISFANLVRQLMEYQFYFKEEEDMNARKLTVRERYLSLLAEIPDILYRVPLKHI
                     NHYLGADVTSLGYLAGSSK"
     CDS             complement(6582..7946)
                     /locus_tag="ctg22_6"
                     /transl_table=11
                     /translation="MKELDLTQGSVPKVLLQFAVPFLIANVLQALYGGADLFVVGQYDD
                     SASVAAVAIGSQVMQTITGIILGITTGTTVLIAIATGAKDNRKVAFTIGSSVWLFSITG
                     VVLTLVMVLFHSRIAELMHTPVEAMVDTKNYILVCSLGILFIVGYNVVCGILRGLGDSK
                     TPLYFVGLACVINIVLDFILVGYFHWGATGAAIATVTAQGVSFGIALWFLYRHGFHFDF
                     SRKDIRLNRNLSKKILVLGAPIALQDALINVSFLIITVIVNQMGVIASASLGVVEKIIV
                     FAMLPPMAISSAVATMTAQNYGAGLIKRMNKCLASGIGIALVFGVSVCVYSQFLPETLT
                     AFFTKDAAVVAMAADYLRGYSIDCIVVSFVFCINSYFSGQGNSLFPMIHSLIATFLFRI
                     PLSYWFSQIDSSSLFIMGFAPPISTVVSLLICIWYLRYTQRKLYLRGTMMPAMSN"
     CDS             complement(8183..9748)
                     /locus_tag="ctg22_7"
                     /transl_table=11
                     /translation="MENESSLLSFRHIYYRGKLNSCNYTCSYCPFGKKSHLADTTQDEQ
                     AWNRFIAAIEQWKGEPLQLFIIPYGEVLIHRYYRKGMVHLAALPQVTGISCQTNLSFPA
                     KHWLDEIRVAPTVISKIRLWASFHPEMTSVEKFAHQIHILHHAGIQVCVGAVGNPSAKV
                     VLNDLRNALLPDIYLFINAMQGLRAPLSQEDIQFFSQLDNLFEYDLKNAPVQWEVCAGG
                     RDNCFIDWKGDMYACPRSRVKIGNFYQGDGAVVPLSCKRKVCDCYIAFSNLNNHPLHRI
                     MGEGAFWRIPDKPLITTVFFDVDGTLTDSQGKVPESYANALRYMAQSVSLYLATSLSME
                     QAKKKLGKALFDLFRGGVFADGGLLSYSRQIKCLPVKVYPEVYGESSKVTIHSYEGVVY
                     KYSILVRDKEQRESILTRLKENPCQVFHKAPLITVIHPEASKKEGMLQLCKALGLASEH
                     TLVVGNSLKDWPMMSVVSHSCAVMNAEPLLKECARYTLNPDRLAAFFRFSNGDPIDQTS
                     SDNS"
     CDS             complement(9760..11037)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Radical_SAM"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg22_8"
                     /sec_met_domain="Radical_SAM (E-value: 2.7e-16, bitscore:
                     51.8, seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNQPLPRYVDYMYSYPHKTAYRSFPSPVSLVPYLKQVEGQKASLY
                     FHIPFCSHKCGYCNLFSLQTNRADYIATYLETLHKQAQQLSPLTTGLAFDSFAIGGGTP
                     LLLTVPQLEYLLDTAALFGVHPSHTFTSVETSPEYADPTRLDLLKQAGVARVSIGVQSF
                     LDEELTALKRRPRRDMINQALEAIRKRQFPFFNIDLIYGIRGQTVASFLYSLEQALLFQ
                     PNELFIYPLYVRPGTAITERESDDVCFQMYCAACDLLKDRGFLQTSMRRFIHHPSTDAE
                     ISCGDEVMLSCGSGGRSYLGNLHYATRYTVCQRCIAGEIDDYMGTTDFTVARNGFILSQ
                     EERRQRFIIKNLMYYMGLDKAEYKRRFGESPDNVMLFRQLAERQWIENTDNGRICLTSD
                     GMAYSDYIGQLFITPEIRELMETYSY"
     CDS             complement(11034..11888)
                     /locus_tag="ctg22_9"
                     /transl_table=11
                     /translation="MQIDELPAGEQTQNPDLDMNQVVGTHDILMLCFDTLRYDVSKEEE
                     EAGRTPVLNSHGGEWEKRHAPGNFTYPSHFAIFAGFLPSPAEPHSLRSRKWLFFPVQAG
                     TGRIPPAGSYPFTEATFVQSLANVGYETICIGGVNFFSKRNELGRVFPGYFTKSYWLPT
                     FGCTAPDSTEKQIDFALKKLENYPEDKRIFMYINFSAIHYPNCHYVEGKMKDDKESHAA
                     ALQYVDSQLPRLFQAFQKRGNTLVIALSDHGTCYGEDGYEYHCISHETVYTVPYKHFIL
                     TKK"
     CDS             complement(11875..12885)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp_3"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg22_10"
                     /sec_met_domain="ATP-grasp_3 (E-value: 8.6e-09, bitscore:
                     27.1, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQIIVVSNSLSKRIEYFIEAGKHLQVEVRFMTYGELFNCLPQLRQ
                     AVIKLEPCVSDETNFLKYALLNQAYKETLQRLGEMRLSDDVCFLNTPHALLRALDKKET
                     KQVLMDRGLKVTPMLPSPRSFDELRELLADCGRGCFLKPRYGSGAGGIMAVRYQPNRNK
                     WVVYTTLQQVDGVIHNTKRINRLSTEKEMIPLAEAVMQTEAILEEWIPKEQLQGENYDL
                     RVVCRESEIDYIVVRCSKGSITNLHLNNKAHWWNELSLPEVVRQQIYFQCQEAVQSLDL
                     QYAGVDVLIERGTDIPYIIEVNGQGDHVYQDMFAHNSIYIQQIKNIKKRYNHANR"
ORIGIN
        1 agaaaatata gcagcttcca ttttccatgc agtagccgta cagaccactg tcacacttgc
       61 acgcggttgc aatatcgtag ctccggtatt actctgcggt ggcccattga cttttattcc
      121 ggcccttcga aaagcatttg ccaactatct gaatctgtca caagatacag atttcatatt
      181 accggaaaaa ggaaatctga tccctgcctg gggagcagca ttggcagaga acaatgaaga
      241 aagtattcat ctctccaacc tgatacaggt aatagaaaac aaactaagtg ttacctcacc
      301 tttccagagt gatctttctc ctatattcga cagtgaggaa gaatatcggt catggaaaaa
      361 agaaaaagac cagtataaaa ttcaatatgc cagtctgcgt cccggattac aggaagcaac
      421 tatcggcata gactccggct ctactaccac caaaatcgta gtactcgaca acaatcatcg
      481 tatcctttac tcctattatc acgacaacaa cggaaaccct ataaaaacag tagagaacgg
      541 cttgcagaaa ctatatgaag aatgccggag acgaggaact accctgcgca taaaaggagg
      601 atgttctacc ggttacggag aagatctgat aaaagcggct ttccacatgg atgcgggaat
      661 cattgaaacc atcgctcatt atgctgctgc caaacatatc agcaaagaag tttcttttat
      721 cctggatatt ggagggcagg atatgaaagc catctttgtg aacgacggag taatcaacag
      781 aatcgaaatc aatgaagcct gttcctccgg ttgcggttct tttatcagca catttgcgca
      841 atcgctggat tacagtgtgg aggactttgc caaagcagct tgtttttcgc aagcaccatg
      901 tgatctgggt acacgttgca cagtcttcat gaactccaaa gtaaaacagg tacttcggga
      961 aggagcgtcc gtagcggata tagctgccgg attatcttat tccgttgtta aaaactgcct
     1021 gtataaggtt ctgcaattaa aagacacgga gatacttggc gaccatattg tcgtgcaggg
     1081 aggaaccatg cgtaatgatt ccatcgtacg aagtctggaa aagctgaccg ggaaacaaac
     1141 cttccgcagt aactgtcctg aattgatggg tgctcttggt tgtgccctat atgccaaaca
     1201 aatcgaaaat gcccgggtga cggagctgaa cgagatgctc caatgggcgc aatatacttc
     1261 caagcaactt caatgccggg ggtgcgagaa ccagtgcgcc attatgcgat atacgttcaa
     1321 caatgacaac cattacttct ccggcaaccg atgtgaaaag gtattttcca ataaaggaag
     1381 ccatgcggac aaaggcatca atacgtatga taaaaagctg gaattattat tcgaccggag
     1441 cgcagacatt ccacaacccc tatttaccat aggcattcca cgtattctga atatgtatga
     1501 ggaataccct ttctggcata ccttatttac tgcttgcggc attcaggtac agttgtcggc
     1561 cccctctaca ttcagcaaat acgagactgc tgccggcatg gtgatgtctg ataacatctg
     1621 cttccctgcc aaacttgtgc acagtcatat ccgtaacctg acactgcaaa acgtcaaccg
     1681 gatatttatg ccgttcgttg ttttcgagaa aaaggataag caacagcaaa acagctataa
     1741 ttgccccatc gtttccggtt attcggaagt catcaaaagt gtacaggaag agaatatacc
     1801 gatagatgct ccgactatca ccttcaaaga tgaagcattg ctgtataaac aatgctatga
     1861 atatctgaaa tctttgggta tcagggatga ggtatgcaaa aatgccttct cacgcgcatt
     1921 acaggaacaa tatgctttcg aagaaaaaat tgctgcctat aatcaggaag ttctgaacga
     1981 gggacgggaa aaacacaaac tgattatctt actcgccgga cgcccttacc atagcgatcc
     2041 actgatacag cacaaggttt cggacatgat tgctgcgatg ggagtttatg tgataactga
     2101 tgatattgtc cgccagcagg agatttcatt ggaaaagact cattacctct ctcaatgggc
     2161 atttaccaac cgtattctga aagcaaccaa gtgggcggca atgcaagagg gtgacataca
     2221 atatatgcag atgacttctt ttggctgcgg tccggatgct ttccttatag atgaagtacg
     2281 taacttgctg aaacgatacg gcaagaatct tactttgctc aagatagacg atgttaataa
     2341 tatcggctcc atcaaattac gagtccgctc gttggtggaa agcttgaatt tcagtttgaa
     2401 acattctcaa gcgaaagatc ccgagccatt tgtttcaact gctcctttca ccaagaaaga
     2461 caaaaagaag aaaatcctcg ctccattctt tacgcctttc atttcaccac tcattccatc
     2521 catcatgaaa gtggccggat atgaaatgga aacgttaccg ttgagcgaca ccgcatcttg
     2581 cgactgggga ttgaaatact ccaataatga ggtatgttat ccggcaacat tgattgtcgg
     2641 cgacatagta aaagccttta aaagcggacg ttatgatcct gccaatacgt gcgttgccat
     2701 cacacaaacc ggtggacaat gtcgtgccag caactatatt tcactgataa aaaaggcatt
     2761 gattgagaat ggatacacca atacaccggt ggtatcactt gctttcggca gtggtattga
     2821 aaatgagcaa tccggtttta aagtaaactg gctcaaggtt ttgccaatca tacttgcgtc
     2881 tgtgttatac agtgattgta tcgctaaatt ctattatgca gccgtcgttc gtgagaaaga
     2941 acggggacag gccgcccgtc tgcgcgatct ttatctggat acagcacagc ccatcatcca
     3001 gaaaaataaa ccggaggact tgttgagtta cttatatctc gctgccagag acttcaacaa
     3061 aatctgtgaa cagagatcct gtcacaaagt aggtattgtt ggagaaatat tcctgaagtt
     3121 caaccctttt gctcaaaagg acgtcacctc atggctcatc aaccagaaga tcgaagtgat
     3181 tccgccactg ataagtgatt tcttcatgca gggatttgtc aacctgaaag tgagacagaa
     3241 ccaacacttg cagcgaaaac tcactcccga ctttgttatc gactggttat acaagaaagt
     3301 ccagaagcag attaataaag tgaatgaaat cggcaaaaat ttcaattact tcacgccgtt
     3361 cgaatcaatc tttgaaaagg cagaaaaagc taaacaagtc atctccccgg gcacccagtt
     3421 tggagagggt tggctgatat ccggtgaaat actatccttt gcttcccaag gagtcaatca
     3481 tgtcattagc ttgcaacctt tcggatgcat tgccaatcac attgtagaaa aaggaataga
     3541 aaaacgtata aaatcgctgt gccctcaaat gaatatacta tctttagact ttgacagtag
     3601 cgtcagcgat gtgaacataa caaacagatt attacttttt attgacaaca taaacaacta
     3661 aaattatggc tacaacggaa catagcgatt tagagcagca aataataaaa actgcccaac
     3721 aactttttat agaaaaagga tttgtggaga ccagcatgag tgatattgct gcaacggtag
     3781 gaatcaaccg gcccacttta cattattatt tcagaaccaa agataagatg ttcaaagccg
     3841 tgttcggctc gatagtcatg tctttaatgc cgaaaataca ggatatagta aaacaggata
     3901 tcccatttat ggagcgacta agcatgattc tggatgagta tattgagctt ttcacaagta
     3961 atccctgtct tcccagattc atttgcggag aaatacagcg tgatgtaaac cacttgcttg
     4021 ccactgcaaa agaacttcag ttcggagatg ctttatccca agtgaaagac agtatactga
     4081 cagcaatgga agacggtaaa cttaaaaagg ttccgataca tattgtattt ctgactgtct
     4141 acagcctatt gagctatcca tttcttgcca agaacctgat agtatcttta ttcttggaag
     4201 atgaagccgc ttttgctgac ttcctgcaag aatggaaaca aaacatcatc aaccaattgc
     4261 agaacttatt gtgttatgag gaatagtata gatactatat aaggaggtgt gtcataatga
     4321 ataataaaac gcagattaac gcaaattatc gcagattatt ccaattatat tgatatatta
     4381 atcaacgact tataaaatta tttctgcgat aatttgcgtt aatctgcgtt ttgacacact
     4441 ccgttattac cattccaatc accccatctt gcaccttatt cgaccacaaa atcttccgat
     4501 ttaaaattac tatagaaacg tcctgaaata gcagtaaact tcaatacaca gtaatcggga
     4561 tccgtcactc cctccggata atacatggta tctccctcct gccagatcat ctctttactg
     4621 gcactatccg tcaagacatc catcgtaccg cgtagcatga cacctctaaa gaatctcgta
     4681 tcacagaagt agatacacgc atggttgttc tcacggtatt gcgccacacg catggacgaa
     4741 gtatttgttg tcagataaat agtttttatc ccctttcttt ttctgggttg cagcattgct
     4801 ttgatggtag gaaatccttc accgtctatc gaaccgataa aagctgtttt cagcttatca
     4861 atcatgttgc ctactgtttt ttccgcgtct ctcatcattt tactttttat tattggttta
     4921 ttatctgatg cgaaagtaga gaaatgccag gaaagcaatg caataaaaag aaaggtagaa
     4981 atagcacttt ttacggtttg tgtactttac gatacaataa cggagtttct cccgtatgct
     5041 gccggaagct acggataaaa taagaaaccg ttgaaaaaca gagttcaaat gcaatatcag
     5101 ctataggaaa gtccgtataa acaagcagcc tcttagcctc ttccatcacc ttgctctgaa
     5161 tatattgttt tgcgctgatt cccatggtcg aggttatcat ctcattcaga taattaggag
     5221 taatgcagag cttatccgca taatattgaa ccgaatgttg ctcttttgca tgtgtagcaa
     5281 ccaaattcat gaatttactt acatgattat tggaaacttc cctacttctg ccctcctcta
     5341 tcgaagtcat tttaaggtaa gcacggtcca gcaacatcag gacttcataa agcaatgctc
     5401 tcaaaacgtg tacatcgccc tgttgatacg aatcaatctc catctttata tcatgcaagg
     5461 tttcaagtat gcgtgtataa agctcatcag acaaatgtag tagcgatgaa gaactttcta
     5521 tctgaaaaaa cgaaagatgc tgtacaaaca aagaatcttt aaagaggaaa gacaaaaatt
     5581 cttcttcgaa aatcagagca tacccattgg tgatatgatg agtatcccag ttccggattt
     5641 cccccggttt agagaaaaga acgtcacgag gaattgcttc ataggtttgg ttatcgactg
     5701 aaaaagctcc cttaccttct gttataaaag taatatcata ataatttaga gtgtggacag
     5761 cacttttagc caggaacttc ttcacatact tcagttctac tacatcgacc aaaagttcac
     5821 tcccatactt atgcttataa aaagtatatc gaggtattga gtttttcatt cagaatacaa
     5881 aaatagtatt ccttaccaaa taatccaaag acttttcaaa ttcgattcga ttgaataagc
     5941 catgaaccat ctgataagga atacatagaa aaatatgtct aggttatatt tcctatttag
     6001 aacttccggc cagatatccc aaactggtca catctgcccc caagtaatga ttaatgtgct
     6061 tcaatggcac cctgtacaga atatccggaa tttccgccaa taaagagagg tacctttccc
     6121 ttactgtcag cttgcgggca ttcatatcct cttcctcttt aaagtaaaac tgatactcca
     6181 tcagttgacg gaccagattc gcaaatgaaa ttgaagatgc acacaactct tcaatctcct
     6241 cttcactgat gtaataagca gcacatttcg tcagtgtctt gatagaatac tgacttgaat
     6301 tatagcataa cacagcatca cccgcagaga aaaaccgatt ggttctctct tctccttcat
     6361 gagtggtata tgtatgcaaa ataccggaaa caataatgta caagctctgt tctggcaatg
     6421 tggcagaagc aatcgtttct cctttatcca gatacaccat ttccattcga gccaacagct
     6481 ctttcacttc tctttcatcc acctgatact caaaacagag tttcttcaaa taagcttcca
     6541 tacaaaatag attttagtta atatatgtca cttaaaaaca cctaattcga catagcaggc
     6601 atcattgtgc ctctcaaata taatttcctt tgggtatatc gtaaatacca gatacagatc
     6661 aataatgaaa cgaccgttga aatgggtgga gcaaatccca tgataaacag cgacgagcta
     6721 tctatctggc tgaaccagta tgacaacggt atacggaaca ggaaagtggc tatcagactg
     6781 tgaatcatcg ggaataacga gtttccttgt ccgctgaaat aagaattaat gcagaacacg
     6841 aaactaacca cgatgcagtc gatgctatac cctcgcaaat aatctgccgc cattgccacc
     6901 acagcagcat ctttcgtaaa gaaagcagta agagtctccg gcaggaattg cgaatacacg
     6961 caaaccgaca caccgaaaac aagagcaatc ccaatccccg aagccagaca tttattcatt
     7021 ctcttgataa gtcccgctcc atagttctgt gcagtcatgg ttgccacagc cgatgatata
     7081 gccatcggag gcagcatagc aaacacgatg attttctcaa caacacccag ggaagcagat
     7141 gcaatgactc ccatctgatt gacaatgaca gtgataatca gaaaagaaac attgattaaa
     7201 gcatcctgca aagcaatagg tgctcccaac accaagatct ttttagacag attccggttc
     7261 aatcgaatat ctttccgtga aaagtcaaaa tggaatccgt gccggtataa gaaccagagc
     7321 gctattccaa agctgactcc ttgtgcagtt acagtagcga tagccgctcc cgtagccccc
     7381 caatggaaat aaccgaccaa tataaaatcg agcactatat ttatcacaca tgccagccca
     7441 acaaaataaa gtggtgtttt agaatcaccc aatccacgca aaataccaca tacaacatta
     7501 tatcctacta taaacagaat acccagagag cataccaaaa tatagttttt cgtatctacc
     7561 atcgcttcga caggagtatg catcagttct gctatccgac tatgaaaaag caccatgacc
     7621 aaagttagca ctacgccggt tattgaaaac aaccatacgg aagacccgat agtaaaagct
     7681 acttttcgat tgtctttagc tccggtagca atagcaatca gcactgttgt cccggtagta
     7741 atacccagaa taatacctgt aattgtctgc atcacctgac taccaatagc tacggctgcc
     7801 acacttgccg aatcatcata ttgtccgaca acgaaaaggt cagctccgcc ataaagtgcc
     7861 tggagcacat tggcaatcag aaaaggtact gcaaactgca acaatacctt cggtacgctt
     7921 ccttgtgtca aatctaactc tttcatagtt tcttcgatac ttttcctctt tatcttattt
     7981 tgttacaaca aaaaaaagtg ccggacaagc gaatgatttg caccattcat cttatccagc
     8041 actataatta ttattatagc accctccgat gaggattttt atgcctgtcc ctatttcagg
     8101 gctgcaaata tgggctttgt tttcataatt accaaatttt aaccggtttt tattttctta
     8161 tgaagatgta actagctata tatcaactat tatcagacga ggtttggtct ataggatctc
     8221 cgttagaaaa acgaaagaaa gctgccaacc gatccggatt cagcgtataa cgtgcgcatt
     8281 cttttaataa gggttccgca ttcattacgg cacaagaatg agaaaccacg gacatcatcg
     8341 gccagtcctt taacgaattt cctacaacta aagtgtgttc agaagctaaa cccaaagcct
     8401 tacataactg aagcatcccc tcttttttac tcgcttcagg atgaatgact gttatcagcg
     8461 gagctttatg aaagacctgg cagggatttt ctttcaaccg ggtaagaata gattctctct
     8521 gttctttatc acgtaccaat atactatact tgtaaaccac tccttcataa ctatgaatag
     8581 taacttttga cgattctcca tatacctccg gatatacttt caccggcaaa cacttaatct
     8641 gccgcgaata agataataaa cctccatctg caaacactcc tcccctgaat aaatcaaaaa
     8701 gagcctttcc cagctttttc ttcgcctgct ccatcgacag agaagtggca agatataagg
     8761 aaacggactg tgccatatat cgcaaagcgt tagcataact ttctggaact tttccctgtg
     8821 aatcagtcag tgttccatcc acatcgaaga aaacagtcgt aataagtggc ttgtccggta
     8881 ttcgccagaa tgccccttct cccattattc gatgtaaagg gtgattgttc aggttactaa
     8941 atgcaatata acagtcacaa accttcctct tgcaagataa cggcacaaca gctccatcac
     9001 cttgataaaa attacctatc ttcacccggc ttcggggaca agcatacata tcccctttcc
     9061 aatcgataaa acaattatcc cttcctcctg cgcaaacttc ccattgtacc ggagcattct
     9121 tcaagtcata ctcaaaaaga ttatccagtt gactgaaaaa ctgaatatct tcctgactta
     9181 atggtgccct taacccttgc atagcattaa tgaataaata aatatccggc aaaagagcat
     9241 tccgtaaatc attgagtacg acctttgcag agggatttcc taccgctccg acacatacct
     9301 gtattcccgc atgatggagt atatgaatct gatgcgcaaa tttctctacc gaagtcatct
     9361 caggatgaaa actagcccaa agccttatct tacttatcac agtgggagcc acacgaatct
     9421 catcaagcca gtgtttagcc ggaaaagaaa ggttagtctg acaggaaatt ccggtcacct
     9481 gtggcaatgc cgccaaatgc accattcctt tccgataata acgatggatc aatacttcac
     9541 cgtaaggaat aataaataac tgcaacggct cccctttcca ttgttcaata gctgctataa
     9601 aacgattcca tgcctgttca tcctgtgtcg tatctgccag atgcgacttc ttgccgaaag
     9661 gacaataaga acaggtatag ttgcagctat tcaatttgcc gcgataatat atatgcctga
     9721 aggaaagtaa agagctttcg ttttccattt ctatttcgtt caataagaat aagtttccat
     9781 cagttctctt atttcaggag taatgaacaa ctgaccaata taatcggagt atgccattcc
     9841 gtcggaagtc agacaaatac gaccgttatc cgtattttct atccattgcc gttcagctaa
     9901 ctgtcgaaac aacatcacat tatccggtga ttctccaaag cgacgcttat attcggcctt
     9961 atcaagcccc atataataca tcagattttt aatgatgaaa cgttgtcgcc gttcttcctg
    10021 agaaagaata aatccattac gagccactgt aaaatcagta gtgcccatat aatcatctat
    10081 ctctccggca atacaacgct ggcaaacagt ataccgggtg gcataatgca aattacccag
    10141 gtaactgcgt ccgccggagc cacacgacag catcacttca tccccacatg agatttccgc
    10201 atcagtagac ggatgatgaa taaaacgtcg catcgacgtt tgtagaaaac ctctgtcttt
    10261 caacaaatca caagcggcac aatacatctg aaaacagaca tcgtcggatt cccgctccgt
    10321 gatagccgtt cccggtcgta catatagcgg atagataaag agttcgttag gctgaaacag
    10381 aagagcctgt tccaatgaat aaagaaagct ggccacagtt tgtcctctga ttccgtaaat
    10441 caaatcaata ttaaaaaacg ggaattgtct cttccgaata gcctccagcg cctgattaat
    10501 catgtctcgc cggggacgtc ttttcaaagc tgttaattct tcgtcaagga aactctgtac
    10561 gccaatactc acacgagcta ctcctgcttg cttcaacaag tccaaacggg taggatcggc
    10621 atattccggc gatgtttcta cggaagtaaa ggtatgtgaa ggatgcactc cgaataaggc
    10681 agccgtatcc aataggtatt ccagttgagg aacagtgagg agcaacggtg tgcctcctcc
    10741 aatggcgaaa ctatcaaatg ccagtccggt agtgagtgga gacaactgtt gcgcctgctt
    10801 gtgaagagtt tccaaataag ttgcgatata atccgcacga tttgtttgca gagaaaacag
    10861 gttgcaatat ccacatttat gactacaaaa aggaatatgg aaataaagcg atgctttctg
    10921 tccttccacc tgtttcaggt aaggaaccag cgaaaccggg gacggaaaag aacgataagc
    10981 agttttatgt ggataactat acatatagtc tacatatcgt ggtagcggtt gattcatttt
    11041 ttcgttaaaa taaagtgttt gtaagggact gtataaaccg tttcgtgaga tatgcaatga
    11101 tattcatatc catcctctcc atagcaagtg ccatgatcgg aaagagcaat caccagcgta
    11161 tttccccgct tctgaaaggc ctgaaataaa cggggtagct gactgtcgac atattgcagc
    11221 gcggcagcgt gtgattcctt atcatccttc attttgcctt ccacataatg acagttcgga
    11281 taatgaatag cagaaaaatt gatatacata aaaatccgtt tgtcctccgg atagttttcg
    11341 agtttcttca atgcaaaatc aatttgtttt tcagtactat cgggtgccgt gcatccaaag
    11401 gtcggcagcc aataactttt agtaaagtaa ccgggaaaca cacgccccag ttcattacgc
    11461 ttgctgaaga agttcacccc tcctatacaa atcgtttcat agcctacatt ggcaaggctt
    11521 tgcacaaaag ttgcttccgt aaacggataa cttcccgcag gcggaatacg tcccgtacca
    11581 gcttgcacag ggaaaaacaa ccacttacgg ctgcgtagcg aatgaggttc cgccggagaa
    11641 ggcagaaatc ctgcaaagat ggcaaaatga gacgggtaag taaaatttcc cggcgcatgt
    11701 cttttttccc attctcctcc gtgactgttc agtaccggtg ttcttcctgc ctcttcttcc
    11761 tccttgctga catcataacg caaggtatca aagcaaagca tcaatatatc atgagtaccc
    11821 accacctgat tcatatccag atccggattt tgggtctgtt cgccagccgg cagttcatct
    11881 atttgcatgg ttatatctct tttttatgtt ttttatctgt tgaatataaa tagaattatg
    11941 agcaaacata tcctgataca catgatctcc ctgtccgttg acttctatta tataaggaat
    12001 atctgttcct ctctctatca gtacatccac tccggcatat tgcaaatcca aagattgaac
    12061 cgcttcctga cactgaaaat agatttgttg ccgcactact tccggcaaag acaattcgtt
    12121 ccaccaatgt gccttattgt tcagatgcag attggttatg cttcctttac tgcatctcac
    12181 aacgatataa tcaatttcag attcccggca cactacacga agatcataat tctctccctg
    12241 caactgctct ttaggaatcc attcttctaa aatagcttct gtttgcatca cagcttccgc
    12301 caacgggatc atctcttttt ccgtactcaa acggttgata cgtttagtgt tatgaatgac
    12361 tccatccact tgttgcaagg tagtatagac tacccattta ttccggttgg gttgatagcg
    12421 aacagccata atacctcccg cccccgaacc gtaacggggt ttcaaaaagc atcctctacc
    12481 gcaatcggca agaagctctc tcaactcatc aaaagaacgg ggagaaggta acatcggagt
    12541 cactttcaac cctctgtcca tcaacacttg tttagtttcc tttttatcaa gagcacgtaa
    12601 taaagcatgg ggagtattca aaaagcacac gtcatcagat agcctcatct cgcctaaacg
    12661 ttgcagtgtc tccttatatg cctgattcaa cagcgcatat ttcaggaaat tcgtttcatc
    12721 gcttacacaa ggttccagtt tgataactgc ctgccgtagt tgcggcaagc agttaaaaag
    12781 ttccccgtaa gtcataaaac gaacttccac ctgcaagtgt ttgcctgctt caataaagta
    12841 ttctatacgt ttggacagag agttgctgac aacgattatc tgcatctcct attctgtaat
    12901 catcgggtaa taccacaatt caccatcata ttcatctgcc tcttcagttt cagcaatatc
    12961 tattttcata gggagactct gcaactgttt cttcatctcc ttgctcaaat aattatagcg
    13021 catattgata aacttcaaat gagcgatctt atccatatta tccagcaata attgggcacc
    13081 ttcatctttg agagtaccag ccgaaacatc cattgtttca agttggggaa gaatatccga
    13141 ctccaggaac atttctacaa tcttgtcctg ttcttcagag ttgacgatcc ccagataagt
    13201 cagcttcggg aaacgttctt tggagaacaa cggacggaat atctcaatat cagcttcaaa
    13261 tccataatct tccacaccaa catatagaat cagtttttcc agattgggga aatcagaacc
    13321 aagaatatct tctaccactt cggtaggcag gccaccactg ataatttcga gtgaccgcaa
    13381 ctccggccgt gaagtctttc ccaaacgcag attattggtt cctttgattt tcagatcttt
    13441 caatttaggc atggcatcga gcagcggact aatatcagct tgttcaatcc atgaaatctc
    13501 ctgttcttcc tgctcaatat ctccccagaa caagccttct atttgtgcga acttctcctt
    13561 attttcaatc attccctgta ataaggcaga acagtcgcca ccctcataat cccaacaacc
    13621 gattgttatt tgtttatatt cagagagatg tttatctttc a
//
