LOCUS       c00016_gnlPro..        14739 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|KOEEGCMD_16.
ACCESSION   c00016_gnlPro..
VERSION     c00016_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-04 22:34:23
            Original ID  :: gnl|Prokka|KOEEGCMD_16
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 72160
            Orig. end    :: 86899
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14739
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[82160:86804]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..14644
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..14739
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14739
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="2"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             complement(770..1381)
                     /locus_tag="ctg16_68"
                     /transl_table=11
                     /translation="MQILKDNIRSRILDVAKQQFELKGYSKTSMREIAVDVGVGVGNIY
                     NYFKSKDELFHEVVRPVLYALEMLLQEHHGIQGEDIMMMRSEEYLETCINEYISLYDTH
                     HRLMKILLFRAQGSSLERFRENYTDRSTELVKVWFTVMQRKYPMINIAIPDFIIHLHTV
                     WMFTMFEELLRHSIAKQEMKAILHNYILFEIQGWRAIIRI"
     CDS             complement(1480..2001)
                     /locus_tag="ctg16_69"
                     /transl_table=11
                     /translation="MKMKNCIKTVCFLFWTCVMFIACIDDDVEEGTVDLQTGENIPVFS
                     VVMDDGQIITSETLKGEVSLIVFFHTGCPDCRKELPVLQKIYTDYGQRIRMVCISREES
                     SAEIVRYWDENHLTLPYSAQENRTVYYQFAKSGIPRVYAIDKELVIRSVFTDNPLASYE
                     DLAEAIETCL"
     CDS             2061..3236
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MFS_1"
                     /gene_functions="transport (smcogs) SMCOG1058:Major
                     facilitator family (Score: 92; E-value: 1.2e-28)"
                     /gene_kind="transport"
                     /locus_tag="ctg16_70"
                     /sec_met_domain="MFS_1 (E-value: 1.6e-28, bitscore: 92.0,
                     seeds: 192, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKQELKENQGLPASLLWTLAIIAGISVANLYYNQPLLNRISRDLQ
                     TSEFTANLIAMITQIGYAIGLLFIIPLGDLFKRKTIILINFTVLIVSLLTIALTPYIHL
                     ILFASLLTGICSVMPQIFIPIAAQFSTPKTKGRNVGMIVSGLLTGILASRVVSGIVGEY
                     LGWRFIFFVAAGMMVICLIIIMRVLPDMPCNFKGKYSDLMKSLFSLVIEYPQLRISSLR
                     AGIAFGSFLALWTSLAFKMGQAPFFAGNNIVGLLGLCGIAGALTASYIGKYVHVLGVKR
                     LNYIGCGLIFVAWFSLYFGQDSYVGIITGIFIIDIGMQCIQLSNQTTIFALNPKAANRI
                     NTIFMTTYFIGGSVGTFLAGTFWHWFGWQGVVGTGIALTACSFMINIFAKR"
     CDS             complement(3238..3627)
                     /locus_tag="ctg16_71"
                     /transl_table=11
                     /translation="MEIDLTTPALLFSAISLIMLAYTNRFLSYAQLVRTLKDQYRENHS
                     AVTAAQISNLRKRLYLTRAMQVTGIGSLLLCVVSMFLMYIQLYLISVYIFGLALVLLII
                     SLGISVREIYISVKALELHLSDMDS"
     CDS             3746..4915
                     /locus_tag="ctg16_72"
                     /transl_table=11
                     /translation="MQTIKLYIKDWLAIHPYIQQQTTDRYFVDLANRLYSTCTIREIPE
                     SIKKKLCLYTAAYFEDVISGLGLWQAFIKKHLELYDTSLPFYTIRPDYIKDEINEEDIR
                     FIIWNTLEKAPYKHLYINPMDRNIEETAHLFFRILDEEYETAPANATLQEFFMDFKGKE
                     DANHKLRWLFGHTYLTEPSVQEYIAQVTETDKFIIPCGPLALFLHEWIDLLTNGETECW
                     EEIEGLYPAIPEISDEMKERNHHTYQLFTQGTNGARIVYLKSYKELHSFLTQVLQWPDD
                     SNHTLPQMKEHKDFIMMVNSEKGILLAKDICKYISDPLNPMYDAATAAQEAFSLLTIPT
                     KCPPDLMEYLINNHYIPDAQFPEFGEKELVQKNADFIARHSLLYYYRGD"
     CDS             complement(4912..5919)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Hacid_dh"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Hacid_dh_C"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg16_73"
                     /sec_met_domain="Hacid_dh (E-value: 2.1e-31, bitscore:
                     100.8, seeds: 88, tool: rule-based-clusters)"
                     /sec_met_domain="Hacid_dh_C (E-value: 2.4e-57, bitscore:
                     185.6, seeds: 144, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAYKIAFYDTKPYDEHSFTEANEKFGFDIRYYKGHLNMNNVVLTK
                     GVDVVCIFVNDTADAEVIRAMADNGVKLLALRCAGYNNVDLAATAGKMKVVRVPAYSPY
                     AVAEFTVALMLSLNRKIPRATMRTRDGNFSLHGLMGFDMHGKTAGIIGTGKIAKILIQI
                     LRGFGMNVLAYDLYPDYNFAREHQVVYCTLDELYHSSDIISLHCPLTEQTKYLINDYSI
                     SKMKDGVMIINTGRGQLIHTNALIEGLKTKKVGYAGLDVYEEEEPYFYEDKSDKIIDDD
                     TLARLLSFNNVIVTSHQAFFTKEAMTNIAHTTLQNVKDFVEGRPLVNEVAVGRV"
     CDS             complement(5985..6566)
                     /locus_tag="ctg16_74"
                     /transl_table=11
                     /translation="MLENLEKYKIILASNSPRRKELLSGLGIKYEVKTLPGIEETYPDT
                     LKAEEIPLYIACEKAAAYRNTMHPDELIITADTIVWLDGVVMGKPHNEDDARQMLWKLS
                     GKTHQVITGVCLTTARTQRSFSAVTEVTFAELSDEEINYYIRVYKPMDKAGSYGIQEWI
                     GFIGVCGISGSYFNVMGLPVQCLYTELKKL"
     CDS             complement(6584..7102)
                     /locus_tag="ctg16_75"
                     /transl_table=11
                     /translation="MINYDLKKIKALVFDVDGVLSAETIYLHPNGEPMRTVNIKDGYAL
                     QLAVKCGLHVAIITGGNTEAVRKRYEGLGIKDVYLAAAVKTREYAHLKEKYGLQDEEIL
                     YMGDDIPDYEVMRLCGLPCCPADAAPEIKETAVYISHRNGGYGCARDVVEQVLKAQGKW
                     MAHERAFGW"
     CDS             complement(7108..7914)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) F420_oxidored"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg16_76"
                     /sec_met_domain="F420_oxidored (E-value: 1.1e-09, bitscore:
                     31.3, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIVLIGAGNVATHLGIALQKAGCLILQVYSRTEESASALADRLL
                     VDYTIVPDEIRRDADLYIVALKDAVLRQLAPVLVKGREQALFVHTAGSMPMDLWKGLVK
                     RYGVLYPMQTFSKQREVDFNTVPFFIEASAPAEVGVLRMVAVRLSPKVYEVTSGQRRHL
                     HLAAVFACNFANHMYALSSHILEKQGISFEVMLPLIDETAGKVHELSPTQAQTGPAVRY
                     DENVISKHLEMLADEESLQELYEKISKSIHNLPLSVIQTNKEGKNS"
     CDS             complement(7914..8237)
                     /locus_tag="ctg16_77"
                     /transl_table=11
                     /translation="VAAVNHKDTYKASAVFLIVMGMLYLIDKFIGFASHGLPWVMQKDN
                     LLLYAAVIFLWFKADKSVGIVLAGIWLILNISLVIALLGQMSAYLLPAALLLGVILYLV
                     STR"
     CDS             complement(8240..8776)
                     /locus_tag="ctg16_78"
                     /transl_table=11
                     /translation="MEQFSDLIKNRRSMRKFTDQELTQEEVVALLKAALMAPSSKRSNC
                     WQFLVVDDKDMLEKLSHCKEMGAAFLADAAMAVVVMADPLASDVWIEDAAIASIMIQLQ
                     AEDLGLGSCWIQVRERFTATGMPSGEYVHTLLDIPLQLQVVSIIAVGHKGMERKPFNED
                     HLQWEKIHINKFGGK"
     CDS             8822..9844
                     /locus_tag="ctg16_79"
                     /transl_table=11
                     /translation="MWIDKQKTINLQLEMPVRLSTYRKGNAIPPLPGTNIFHSTELFHV
                     FEMTRGYEPLLIVAYIGNRPVGKLLAVIRKSMRLFPPAIIKRCEIYGTGEYFDEEQNKE
                     DLFGEMLEHLTNEVLCKSFLIEFRNLENPLFGYKAFRKNNYFAINWLRVRNSLHSKVPY
                     ERLSMSRKRQINKALRNGAIMEVADNEKDIQDFSRMLKKAYSSQVRKHFPDIGFFRLLA
                     WQNPEKELAKVFLVKYKGKIIGGSICLFSKESAYLWFSGGMRKTYAFLYPGILAVWAPI
                     TYAHEKGYAHLEFMDAGLPFKKHGYRDFILRFGGKQSSTRRWFRFSWKWLNKLLCKFYI
                     "
     CDS             10001..10414
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Glyoxalase_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg16_80"
                     /sec_met_domain="Glyoxalase_4 (E-value: 4.6e-25, bitscore:
                     80.5, seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKISHIEHLGIAVKSIEEALPYYENVLGLKCYNIETVEDQKVKTA
                     FLKVGDVKIELLEPTSPESTIAKFIEKNNGNGGMHHLAFAVEDGVANALAEAETTGIRL
                     IDKAPRKGAEGLQIAFLHPKSTLGVLTELCEKP"
     CDS             10517..12070
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Btheta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg16_81"
                     /sec_met_domain="CT_Btheta (E-value: 3.5e-291, bitscore:
                     958.2, seeds: 72, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNQLEKIKELIERRATARMGGGDKAIAKQHEKGKYTARERIAML
                     LDEGSFEEMDMFVEHRCTNFGMEKKHYPGDGVVTGCGTIEGRLVYIFAQDFTVSAGSLS
                     ETMSLKICKVMDQAMKMGAPCIGINDSGGARIQEGINALAGYAEIFQRNILASGVIPQI
                     SGIFGPCAGGAVYSPALTDFTLMMEGTSYMFLTGPKVVKTVTGEDVSQENLGGASVHST
                     KSGVTHFTAKTEEEGLAMIRKLLSYIPQNNLEEAPYVDCTDPIDRLEDSLNEIIPDSPN
                     KPYDMYEVISAIVDNGEFLEVQPHYAKNIIIGFARFNGQSVGIVANQPKYLAGVLDSNA
                     SRKGARFVRFCDAFNIPLVSLVDVPGFLPGTGQEYNGVILHGAKLLYAYGEATVPKVTI
                     TLRKSYGGSHIVMSCKQLRGDMNYAWPTAEIAVMGGAGAVEVLYAREAKEQENPAAFLA
                     EKEAEYTKLFANPYNAAKYGYIDDVIEPRNTRFRIIRALQQLQTKKLTNPAKKHGNIPL
                     "
     CDS             12098..13027
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg16_82"
                     /sec_met_domain="OAD_gamma (E-value: 9.6e-15, bitscore:
                     47.5, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKLNIGIFLSLLLMVGLCSCGEQKSNTKLVLNEVLIENESNFQD
                     DYGVHSAWIEIFNRSFGSADLAGCLLKVSSQPGDTATYFIPKGDVLTLIKPRQHALFWA
                     DGEPNRGTFHTNFTLNAATNNWIGLYDSGKKLLDQIIVPAGTLQANQSYARVSDAANEW
                     EVKGSSADKYVTPSTNNKTINSNAKMEKFEEHDSVGIGMSISAMSVVFVGLLLLFIAFK
                     VIGRISVNLSKRNAMKVKGITDKQEAKEKKLGEAPGEVFAAIAMAMHEMQSDVHDVEET
                     VLTITRVKRSYSPWSSKIYTLRETPHKK"
     CDS             13051..13482
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 64.7; E-value:
                     1.8e-20)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg16_83"
                     /sec_met_domain="Biotin_lipoyl (E-value: 2.4e-20, bitscore:
                     64.7, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEYKYKINGNIYKVAIGDIEDNIAHVEVNGTPYKVEMEKAPKAV
                     MKPVVRPASTSPAPAPTTVVKPAATSTGKSGVKSPLPGVILDIKVNVGDTVKKGQTIII
                     LEAMKMENNINADKDGKITAINVSKGESVLEGTDLVIIE"
     CDS             13484..14644
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg16_84"
                     /sec_met_domain="OAD_beta (E-value: 1.2e-152, bitscore:
                     500.2, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGEFINFLGNNLADFWTYTGFANATVGHIVMILIGLFFIYLAVAK
                     EFEPMLLIPIGFGILIGNIPFNMEAGLKVGIYEEGSVLNILYQGVTSGWYPPLIFLGIG
                     AMTDFSALISNPKLMLIGAAAQFGIFGAYMIALAMGFDPMQAGAIGIIGGADGPTAIFL
                     SSKLAPNLMGAIAVSAYSYMALVPVIQPPIMRLLTTKHERLIRMKPPRVVSHTEKVMFP
                     IIGLLLTCFLVPSGLPLLGMLFFGNLLKESGVTRRLAETARGPLIDTITILLGLTVGAS
                     TQASEFLTIDSILIFALGALSFIIATASGVIFVKIFNLVLGKDNKINPLIGNAGVSAVP
                     DSARISQVIGLEYDPTNYLLMHAMGPNVAGVIGSAVAAGILLGFLM"
ORIGIN
        1 agcagaagta ctcatccttt cctgtgcatc gtaatagaca cgcataaact ccttcgcttt
       61 ctttcccata aaattggaaa attgcaggaa aaggcttaat acgacaactg tcaaacacgc
      121 cactgtcaac catacattta atgagaagaa aatgacaaac atcactgcca ccgtagctat
      181 cacatttacc aaatcgggga tagtatgtgc aatgaatccc tctatcttct cgatgttctg
      241 atccatcgtt ttcttgatgg acccgatgga agtgttgttc agatagccca acggaagttt
      301 accgatatgt tcggataaac ggacacgcaa cccatacaag attcggaatg cggctacatg
      361 agaggacata agggcagcgt acagcaaaac caatccgccg acaagtccac ccagtgcgat
      421 ccatccccaa cgtatcattt cagttccatt tgccaaaaca ggattgctgc catgcaacaa
      481 caactctttc agcacctcat agacagccca atagggcaca agcatacaca tggcactacc
      541 taccgacaac aaacctgcca gcagaagcaa ccctttcttc tgtcccgcaa tctctaacaa
      601 acgggacaat ccttctttct tctttttcat ataattgtac tatatcaaac ggattattag
      661 tgaacggtat tcaaatttgt tcataaaaaa ggaggaaacc tccgtaaaga cttcctcctt
      721 tcctgctgcc ttactgtagc aaccagtctg tatatacaaa ttttacctgt catattcgaa
      781 taatggccct ccaaccttgg atctcaaata gaatataatt gtgtaaaata gctttcattt
      841 cctgtttcgc tattgaatgc ctcaaaagct cctcaaacat agtaaacatc catacagtat
      901 gcaaatggat tataaaatcg ggaatagcta tatttatcat cgggtacttt ctctgcatca
      961 ccgtaaacca gactttgact aattcggttg aacggtctgt ataattctcc cgaaaacgtt
     1021 ccaatgaaga accttgcgca cgaaataaca gtattttcat caatctgtgg tgggtgtcat
     1081 acaaggaaat atattcgttt atacaggttt ctaagtattc ttccgacctc atcatcataa
     1141 tatcctcgcc ctgtattcca tgatgttcct gcaacagcat ttccaacgca tacaaaaccg
     1201 gacgaacaac ttcatgaaac agctcatcct tacttttaaa gtagttgtaa atatttccca
     1261 ccccaacacc tacatccaca gctatctcac gcatggaagt cttggaataa cctttcaact
     1321 caaattgttg tttggctaca tccaaaatac ggctacgtat gttatccttt aatatttgca
     1381 tgtatagtca gttgtgattc tgtttttatg atggcaaagg taatgagctt atcattatct
     1441 gacaatacct atttttaggg attttaccct ctctaaaaac tacaaacagg tttctatagc
     1501 ctcagccaaa tcttcataac ttgccaacgg gttatccgtg aaaacactac ggataaccaa
     1561 ctctttatct atggcataaa cacgaggtat ccccgattta gcaaactgat agtataccgt
     1621 gcggttttct tgggccgaat agggcaaagt caaatgattt tcgtcccaat aacggacaat
     1681 ctctgccgaa ctctcttccc tgctaataca aaccatccgg attctttgac cgtaatccgt
     1741 atatattttt tgcagcacag gaagttcttt ccggcagtcc ggacaacccg tatgaaaaaa
     1801 cacaatcaag gaaacctctc ctttcagggt ttcggaagtt attatttgtc catcatccat
     1861 taccacagaa aaaacaggaa tgttctctcc tgtttgtaaa tcaacagtac cttcctccac
     1921 atcatcatca atacacgcta taaacattac acaggtccaa aacagaaaac agaccgtttt
     1981 tatacaattc ttcattttca tttctatttt tcttctttac aaagataaca tgattttcat
     2041 gaaattacta cttttgcagc atgaaacaag aattaaaaga aaaccaagga ctacctgcct
     2101 ccttactttg gacgctagca attattgcgg gaatctccgt tgccaattta tattataacc
     2161 aacctttatt aaatcgcatc agccgtgatc tccaaacatc cgaattcacc gccaacctga
     2221 tagcaatgat tacccaaata ggttatgcca tcggattgct gttcattatt cctttgggag
     2281 atttatttaa aaggaaaacc attattctaa tcaatttcac agtcctaatc gtttcattac
     2341 taaccatcgc actgactcct tatatccatc tcattttatt tgcctctctg ctgaccggca
     2401 tttgttcggt gatgccacaa atctttatcc ccatagctgc acaattctcc acccccaaaa
     2461 ccaaaggaag aaatgtaggc atgattgtat cagggttact gactggtatt ttggcttcgc
     2521 gcgtagtcag cggaattgtc ggcgaatatt tgggatggcg gtttattttc tttgtagcgg
     2581 cgggaatgat ggtgatatgt ctcatcatta tcatgcgtgt actacccgat atgccatgta
     2641 attttaaagg gaaatatagt gatctgatga aatccttgtt ttcattagtg atagaatacc
     2701 cccagttacg tatttcttcc ttacgtgccg gaattgcttt cggttcattc ctagctctgt
     2761 ggacttcgct ggcattcaaa atgggacaag ctcctttctt tgcaggaaac aatattgtag
     2821 ggttattagg attgtgcggc atagcaggag ctctcaccgc ctcgtatata ggaaaatatg
     2881 tacatgtttt gggagtcaaa cgactgaatt acataggttg tggcttgatt tttgtagcgt
     2941 ggttctcact ttatttcggt caggactctt acgtgggtat catcaccgga atttttatta
     3001 tagatatagg tatgcaatgt atccaattga gtaatcagac tacgattttc gccctcaacc
     3061 cgaaagcagc caaccgtatt aataccattt ttatgacaac ttattttata ggtggttccg
     3121 taggtacatt ccttgccgga acattctggc attggtttgg atggcaagga gtagtaggaa
     3181 cagggatcgc attaacagcc tgttccttta tgataaatat ctttgcaaaa agataaatca
     3241 agaatccata tcactcagat gcagttccag cgccttgacg gaaatataaa tctcgcggac
     3301 agaaatgcct aaagaaataa tgagcagcac cagtgccagt ccaaaaatat atacggatat
     3361 gaggtaaagc tgtatataca ttaaaaacat actgaccacg caaagcaaca agctcccgat
     3421 acctgtcacc tgcatagcac gtgtcagata aaggcgtttg cggagattag aaatctgtgc
     3481 tgccgtaacc gccgaatgat tttcacgata ctgatccttc aacgtgcgta ctaactgggc
     3541 atatgacaga aaacgattgg tatatgccag cataatcagc gatatggctg agaacaataa
     3601 agcaggagtt gttaaatcta tttccatttt tataggtatt tcaaagttag aatattgcaa
     3661 agataaagta aatatcccga tattctcctt cctttttaca atgaaaggaa tatctttgca
     3721 ataaaaataa ttccaataaa ctaatatgca aaccataaaa ttatacataa aagactggtt
     3781 ggctatccat ccttatatcc aacaacagac tacagacaga tattttgtcg atctggctaa
     3841 ccgattatac tccacttgta cgataagaga gattcccgaa tccattaaaa agaagttatg
     3901 tctttacacc gctgcctatt ttgaagatgt catttcaggt ttaggtctat ggcaagcatt
     3961 catcaaaaag catctggaac tatatgatac gtcacttcct ttctatacca tccgaccgga
     4021 ttatataaaa gatgagatca atgaggaaga tatccgtttc atcatttgga acactttaga
     4081 gaaggctcca tataaacatc tgtatatcaa tccgatggac aggaatatcg aagaaactgc
     4141 acatttattt ttccggatat tggatgaaga atatgaaacg gctcccgcca atgccacgtt
     4201 acaggagttc tttatggatt tcaaaggaaa agaggacgca aaccataaac tacgctggct
     4261 gttcggacat acttatctca cagaaccatc tgtacaagaa tatattgcac aggttacaga
     4321 aaccgacaaa ttcatcattc catgtggccc ccttgccctg tttcttcatg aatggattga
     4381 cctgctgacc aacggagaaa ccgaatgttg ggaagagata gaaggactat accctgccat
     4441 tcccgaaata tcggacgaga tgaaggaaag gaaccaccat acctatcaat tgttcacgca
     4501 aggcacaaat ggtgcccgta tcgtatatct gaaaagctat aaagaactac acagtttcct
     4561 tacccaagta ttacaatggc cggacgattc caatcacact ttgccccaaa tgaaggaaca
     4621 taaggatttc atcatgatgg taaattccga aaaaggtatt ctattggcga aggatatatg
     4681 caaatacatc agtgatcctc ttaacccgat gtatgatgcc gcaacagctg cccaagaggc
     4741 attcagcctg cttactatcc cgaccaaatg tccgccggac ctgatggaat atttaataaa
     4801 caaccactat atccccgatg cacaattccc cgaatttggt gaaaaggaac tggttcaaaa
     4861 gaatgcggac tttatagccc gccattcctt attgtattac tacaggggag attagaccct
     4921 ccccaccgct acttcgttca ccaaaggtct accttcaaca aagtctttca cgttttgtag
     4981 agtagtatga gcaatattcg tcattgcctc tttggtaaaa aaagcctgat gtgaagttac
     5041 aatcacatta ttgaaagaca gaagacgagc taaagtgtca tcatcaataa tcttatcaga
     5101 cttatcttca taaaaataag gctcttcttc ctcgtataca tccagaccgg catatcccac
     5161 ttttttggtc ttcagcccct ctatcaaggc attggtgtga atcaactgcc cacgccccgt
     5221 attgataatc atcaccccat ctttcatttt actgatggaa taatcattaa tcagatactt
     5281 tgtctgttct gtcaaaggac aatgcaggga gatgatatcc gaactatgat aaagttcatc
     5341 caaagtacaa taaaccacct gatgttcacg ggcaaaattg taatcgggat aaagatcata
     5401 tgcaagaaca ttcataccaa atccacgtaa tatctgaatt aaaatcttgg caatcttacc
     5461 cgtaccgata attccggcag tcttgccatg catatcaaat cccataagtc catgcaaaga
     5521 aaagtttccg tcacgtgtgc gcattgtggc acgaggaatc ttacgattga gtgacaacat
     5581 caatgccact gtaaattcgg caacagcata tggcgaatat gccggtaccc gtaccacttt
     5641 catcttacct gccgttgccg ctaaatccac attattataa ccagcacatc ttaaagccag
     5701 cagtttaaca ccattatccg ccattgcccg gataacttcg gcatcagccg tatcgtttac
     5761 gaagatgcaa accacatcca ctcctttggt caacaccacg ttattcatat tcaaatggcc
     5821 tttgtaatac ctgatatcaa agccaaactt ctcattagcc tccgtaaacg agtgttcgtc
     5881 gtagggtttc gtgtcgtaaa aagctatttt ataagccata attatttttt atttatagtt
     5941 catataaata acaaaaacac gtcccttact gttcacatac agacttatag ttttttcagt
     6001 tctgtgtaca ggcactgcac agggagtccc atcacattga agtaactacc cgaaattcca
     6061 cagacaccaa tgaagcctat ccactcttgt ataccataag aaccagcctt atccatcggc
     6121 ttgtaaaccc gaatataata attgatctcc tcatcggaca attctgcaaa cgttacttct
     6181 gtcacagcag aaaaacttct ctgagtcctg gcagtagtca gacaaacccc agttatcacc
     6241 tgatgggtct tgccagaaag cttccacaac atctgccgtg catcatcctc gttatgaggc
     6301 ttgcccatga ctacaccgtc caaccataca atggtatcag cagtaataat caattcgtcc
     6361 ggatgcatgg tattccggta agcagccgcc ttctcgcaag ctatatacaa aggaatttcc
     6421 tctgctttca atgtatccgg ataggtttcc tctatgccgg gtagtgtttt tacctcatat
     6481 tttataccta agccggataa caattcttta cggcgcggag aattggaagc aaggattatt
     6541 ttatattttt ctaaattttc caacatagct tttctttatt tcattaccac ccgaaggctc
     6601 tttcatgagc catccatttt ccttgagcct tcaaaacctg ttccaccacg tcacgggcac
     6661 atccataccc cccattacga tgagaaatat aaacagctgt ttcttttatc tcaggtgccg
     6721 catcagcagg acaacaaggt agcccacaca aacgcatcac ttcataatcg ggaatatcat
     6781 cgcccatata gagtatctcc tcatcctgca atccatattt ttccttcaaa tgggcatact
     6841 cccgggtctt taccgcagca gccagataaa catccttgat acccagcccc tcataacgct
     6901 tacgcaccgc ctcggtattt ccaccagtaa tgatggcaac atgcagcccg catttcacag
     6961 ccaactgtaa tgcataccca tccttgatat taaccgtacg catgggttca ccattggggt
     7021 gcaaataaat agtttccgca ctcaataccc catcgacatc aaataccaat gcctttattt
     7081 tctttaaatc atagtttatc ataccactta tgagttcttt ccctctttat ttgtctgaat
     7141 aacagacaaa gggagattat gaatactttt acttatcttt tcgtacaatt cctgcaaaga
     7201 ctcctcatcc gccaacatct ccaaatgttt gcttattacg ttttcatcgt agcgtacagc
     7261 cggacctgtc tgcgcctgtg tgggagaaag ttcatgtact ttgccggcag tttcgtctat
     7321 cagcggaagc atcacttcaa aagaaatccc ctgcttttcc agtatatgtg aacttaatgc
     7381 atacatatgg ttagcaaaat tacaagcaaa gactgccgcc agatgcaaat gcctacgttg
     7441 accggaagtc acttcataca ctttaggact gagacgaact gccaccatac gcagcactcc
     7501 cacttctgcc ggagcagatg cttctataaa aaaaggtacg gtattgaaat caacttcacg
     7561 ctgcttgcta aaagtctgca taggataaag taccccatag cgttttacca accccttcca
     7621 taaatccata ggcatactac ccgccgtatg tacaaacaaa gcctgctccc ttcctttcac
     7681 caatacagga gccaattgtc gcaaaactgc atctttcagc gctacaatat acaaatcggc
     7741 atcccgacgt atctcatccg gcacaattgt gtagtctact aaaagtctgt cagccaatgc
     7801 agaagcagac tcctctgtac ggctgtatac ctgcaaaata agacaccctg ccttttgtaa
     7861 agcgattccc aaatgggtag ccacattgcc ggctcctatc agaactattt tcatcatcgg
     7921 gtcgaaacta aatataaaat aactcctaac aacaaagccg ccggcaacaa ataagcagac
     7981 atctgcccca acaaagctat caccaaactg atattcaata tcagccatat acccgccaat
     8041 acaattccta ctgacttatc ggccttgaac caaaggaaaa taacagctgc atacagtaac
     8101 agattgtctt tctgcataac ccatggcaac ccgtgtgagg caaatcctat aaacttatcg
     8161 atcagataaa gcatacccat cacaatgaga aacaccgcag aagctttata cgtatcctta
     8221 tgattgacag cagccacgtt tacttgcctc caaatttatt gatgtgaatt ttctcccatt
     8281 gtaaatggtc ctcattaaaa ggcttgcgtt ccatgccctt atgtcctacc gctataatgg
     8341 aaaccacctg caactgcaac ggaatatcaa gcagcgtatg cacgtattca cccgagggca
     8401 tcccggtagc ggtaaaacgt tcacgcacct gtatccaaca acttcccaac cccaaatctt
     8461 ctgcctgcaa ctggatcatt atggaagcaa ttgccgcatc ttcaatccaa acatcactag
     8521 ccaacggatc agccatcaca actacagcca tagcagcatc cgctagaaaa gctgccccca
     8581 tctccttaca atgggaaagt ttttccagca tatccttatc atctaccaca agaaactgcc
     8641 agcaattgct acgtttagaa gacggagcca tcaaagcagc cttcaacaaa gcaaccacct
     8701 cttcctgtgt caactcttga tccgtgaact tacgcatact gcgtctgttc tttattaagt
     8761 cactaaattg ttccataata tactcagtta atttattttt ctgcacaaat atacaactag
     8821 aatgtggatt gataaacaaa aaacaataaa tttgcaatta gagatgcctg tcagattaag
     8881 tacatatcgc aaaggaaatg ccattccccc tctgcctgga acaaacattt tccattctac
     8941 cgagttgttt catgtctttg aaatgactcg gggatacgaa cctctgctta tcgtagccta
     9001 tataggaaac cgtcctgtag gcaaactgct ggctgtcatc cggaagagta tgcgcttgtt
     9061 cccccccgca atcatcaaac gatgcgagat ttatggcaca ggcgagtatt ttgatgaaga
     9121 acagaataag gaagacctgt tcggggaaat gttggaacat ctcaccaacg aagtattatg
     9181 caaatcgttc ctcatcgagt tccgcaactt ggaaaatccg ctattcggat acaaagcttt
     9241 cagaaagaac aactatttcg ccattaattg gctaagagta cgtaactcac tgcacagtaa
     9301 agtcccttac gaacggctga gcatgtctcg caaaagacaa ataaacaaag cgttgagaaa
     9361 cggtgccatc atggaagtag ccgacaatga gaaagatatt caagatttct cacgaatgtt
     9421 gaaaaaagcc tattcctcac aggtaagaaa acatttcccg gacatcggct ttttccggct
     9481 attagcatgg caaaacccag aaaaagaatt agccaaagtg tttcttgtga aatataaagg
     9541 caaaatcata ggtggttcta tctgtctttt ctcaaaagaa agtgcttatc tgtggttctc
     9601 aggaggtatg cggaaaacct atgcttttct ttaccccggt attctagccg tatgggcacc
     9661 tattacctat gctcacgaaa aaggatatgc acatttggaa ttcatggatg caggattacc
     9721 gttcaaaaag cacggttaca gggactttat actccgcttt ggcggcaagc agagcagtac
     9781 acgccgctgg ttccgcttca gttggaagtg gctgaacaaa ctcttgtgca aattctatat
     9841 ttaattcatt tttgtctttt tgtctaaagt gttgtgaagc atctcgcaaa taagaaataa
     9901 aattgaagaa atatttcttt atttaactcg aaattacttt ctttgtgcag ttttatctga
     9961 aaacttgagt ataaaaccaa actattaaaa ttataagatc atgaaaatct cacacattga
    10021 acacctgggc attgccgtaa agagcattga agaggccctg ccgtattatg aaaacgtatt
    10081 aggtctgaaa tgctacaata tcgaaacagt agaggatcag aaagttaaaa ccgcttttct
    10141 gaaagtaggt gatgttaaaa tagaactgct ggaacctaca agccccgaaa gcactatcgc
    10201 aaagttcatt gaaaaaaata atggcaacgg tggtatgcat catttggctt ttgcagtgga
    10261 agatggtgtg gcaaatgcgt tagccgaagc ggaaaccact ggcatccgtc tcattgacaa
    10321 agctccgcgt aaaggtgctg aaggtttgca aattgctttt ttacatccca aatcaacttt
    10381 gggcgtcctg actgagcttt gcgaaaaacc ataaaacacg agatctgact attcacgatt
    10441 gaaatcagtg tatttagtct ggttcaagcg taaatagaaa tattttttaa tcgtaaattg
    10501 taaaatcata agtaaaatga gcaatcaact tgaaaaaata aaagagctta tcgaacgccg
    10561 ggctacagca cgcatgggtg gaggtgataa agcaattgca aaacagcatg aaaaaggaaa
    10621 atatacagcc cgcgaacgca tagccatgtt gctggatgaa ggcagtttcg aagaaatgga
    10681 tatgtttgtg gaacacagat gcaccaattt tggcatggag aaaaaacatt atccgggcga
    10741 cggtgtagta acaggttgtg gtaccataga aggacgttta gtttacatct ttgcacagga
    10801 tttcactgtt tctgccggtt ctctgtcaga aacaatgtct ctgaaaatct gcaaagtaat
    10861 ggatcaagcc atgaaaatgg gtgctccctg tatcggtatc aatgactcgg gtggcgcacg
    10921 tattcaagaa ggtatcaatg cgctggccgg ttatgctgaa attttccaac gcaatattct
    10981 tgcttcaggt gttattccac agatttcagg tattttcggt ccttgtgcag gcggagctgt
    11041 ttactctcct gcgctgacag acttcacatt gatgatggaa ggcacatcat acatgttcct
    11101 taccggaccg aaagtggtaa agactgttac aggtgaagat gtaagccaag aaaacttagg
    11161 tggtgcaagc gttcattcta ccaaatccgg tgttactcat tttactgcca agacggaaga
    11221 agaagggtta gccatgatcc gcaaattgtt aagctatatt cctcaaaata atctggaaga
    11281 agctccctat gtagactgta ccgatcctat cgaccgtctg gaagactctt tgaacgaaat
    11341 tatccccgac agccccaaca aaccatacga tatgtatgag gtgatcagcg ccatcgtaga
    11401 taatggtgag tttttggaag tccaacctca ctacgctaaa aatatcatca ttggtttcgc
    11461 acgtttcaac ggacaatctg taggtattgt tgcaaaccag ccaaaatatc tggcgggtgt
    11521 acttgacagc aatgcgtcac gtaaaggtgc gcgttttgta cgtttctgcg acgctttcaa
    11581 tatacctctt gtttcattgg tagatgttcc gggattcctt ccaggcacag gacaagaata
    11641 caacggcgta atcctccacg gcgccaagtt gctgtatgct tacggcgaag cgactgtacc
    11701 caaagtaaca attaccctgc gtaaatcata cggcggatct cacattgtaa tgagctgtaa
    11761 acaacttcgc ggtgatatga attatgcatg gcctactgcc gaaatcgccg ttatgggtgg
    11821 tgcaggtgca gtagaagtat tatacgcccg cgaagccaaa gaacaggaaa atcctgccgc
    11881 attcctagcc gaaaaagaag ctgaatacac caagctgttc gccaatcctt acaatgctgc
    11941 caaatatggc tatattgatg atgtgattga accgcgtaat acccgtttcc gcatcatccg
    12001 tgcattgcaa cagttgcaaa ctaagaaatt aaccaatccg gctaagaagc atggtaatat
    12061 tcctctttaa ttaaaaatta aaaattgaga attgaacatg aagaaattaa atataggaat
    12121 attcctttct ttgctgctga tggtgggttt atgttcttgt ggagaacaga aatcaaacac
    12181 caagctggta ctgaatgaag tgctgattga aaatgaaagc aatttccaag atgactacgg
    12241 agtacacagc gcatggattg aaatattcaa tagatcattt ggtagcgcag accttgccgg
    12301 ttgtttactg aaggtgagca gccagcctgg agatactgct acttatttta tccctaaagg
    12361 tgatgtattg actttgatca aacctcgcca gcacgctttg ttctgggcag atggtgaacc
    12421 taaccgtggt actttccaca ccaacttcac cctgaatgcc gcaacgaaca attggatcgg
    12481 cttgtatgat tcaggcaaga aattattgga tcagattata gttcctgcag gtacattaca
    12541 ggcaaaccaa tcatacgcac gtgtcagcga cgctgcaaat gaatgggaag taaaaggttc
    12601 tagtgcagac aagtatgtaa ctcctagcac taacaacaag actatcaaca gcaacgctaa
    12661 gatggaaaag tttgaagaac atgacagtgt gggtattggt atgtccatat cagctatgag
    12721 tgtcgtattc gtaggcttgc tccttctgtt tattgctttc aaagttatag gccgtatttc
    12781 tgtcaacctg agcaagcgca atgccatgaa ggtaaaaggt attaccgaca aacaagaagc
    12841 caaagaaaag aaactgggtg aagctccagg cgaagtattc gccgcaattg ccatggctat
    12901 gcacgaaatg caaagcgatg tacacgatgt agaagaaact gttcttacca ttactcgtgt
    12961 aaaacgtagc tattcaccgt ggagttctaa gatttatacc ttgcgtgaaa ctccccacaa
    13021 aaagtaagtc accaataaaa agataaaacg atgaaagaat ataaatataa gattaacggt
    13081 aacatatata aggttgccat tggagatata gaagataata tcgctcatgt tgaagtaaac
    13141 ggcactcctt acaaagtaga aatggaaaaa gccccgaaag ctgtaatgaa accggtagtt
    13201 cgtcctgcat caaccagccc tgctccggct ccaactacag tagtaaagcc tgctgcaact
    13261 tctacaggaa aatcgggcgt taaatctccg ttgccaggtg taatccttga tattaaggta
    13321 aatgttggtg ataccgtaaa aaaggggcaa accatcatta tccttgaagc tatgaagatg
    13381 gagaataaca tcaacgcaga caaagacggc aagatcaccg caatcaatgt aagtaaagga
    13441 gaatccgttc tcgaaggtac tgaccttgta attattgaat aatatgggag aatttatcaa
    13501 ctttttaggg aataacctag ctgacttttg gacatatacg ggttttgcca atgctactgt
    13561 tggtcatatc gtaatgatcc tgataggttt attcttcata taccttgccg tggccaagga
    13621 atttgagccg atgttgctca ttcctatcgg ttttggtatc ttgatcggta atattccttt
    13681 caacatggaa gccggactga aagtcggcat ctatgaggaa ggttctgttc ttaatatttt
    13741 atatcaagga gttacctccg gatggtatcc accacttatc tttttaggta tcggtgcaat
    13801 gacggatttc tcggcattga tttcaaatcc taaactgatg ttgattggtg ctgccgcaca
    13861 gtttggtatt ttcggtgcat acatgattgc attggcaatg ggctttgatc cgatgcaggc
    13921 tggtgctatc ggcatcatcg gtggtgcgga cggtccgaca gcaatcttcc tttcatccaa
    13981 actggcgcct aacctgatgg gagctattgc ggtatcagcc tattcataca tggcattggt
    14041 accggttatc cagccgccta tcatgcgtct gctcactacc aagcacgaac gtttgatccg
    14101 tatgaaacca ccacgcgtcg tttctcatac agaaaaagta atgttcccta tcattggttt
    14161 gttacttact tgttttctgg ttccgtcggg tctgcctcta ttgggtatgc ttttctttgg
    14221 taacttattg aaagaaagcg gtgtaacccg tcgcttagca gaaactgccc gcggtccgct
    14281 gattgatacc attaccatct tattaggatt gacagtaggt gcttccacgc aagcttcaga
    14341 gttccttacc attgattcga tcttgatttt cgcgctgggt gcattgtcat ttatcattgc
    14401 tactgcttct ggagttatct tcgtgaagat attcaacttg gtattaggta aggataacaa
    14461 aatcaacccg cttatcggta atgccggtgt atctgctgtt cccgactcgg cacgtatctc
    14521 tcaggttatt ggtctggaat atgatcctac caactacttg ttgatgcatg ctatgggtcc
    14581 caacgtagct ggtgtaatcg gttctgccgt agcagccggt attttacttg gattcttgat
    14641 gtaattcatt gaacaacaac aaataaaatc ctcttcaact aatatgtgga agaggatttt
    14701 ttattgatat agattaagaa atgaatgatt tattatgaa
//
