LOCUS       c00111_gnlPro..        10784 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|OMJBEFCL_111.
ACCESSION   c00111_gnlPro..
VERSION     c00111_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 01:34:00
            Original ID  :: gnl|Prokka|OMJBEFCL_111
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 10784
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10784
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[3925:10007]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      3926..10007
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..10784
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..10784
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             complement(3..1835)
                     /locus_tag="ctg111_1"
                     /transl_table=11
                     /translation="MVYDLTMLKTFYAAYSEKIERVRNVLQRPMTLAEKILYAHLYDGD
                     KVKNYRRGEDYVNFRPDRVAMQDATAQMALLQFMNAGREQVAVPSTVHCDHLIQAYKGA
                     KEDIATATKTNEEVYNFLRDVSSRYGIGFWQPGAGIIHQVVLENYAFPGGMMVGTDSHT
                     PNAGGLGMVAIGVGGADAVDVMTGMEWELKMPCLIGVHLKGKLSGWVAPKDVILKLAGI
                     LTVKGGTNAIIEYFGPGTASLSATGKATICNMGAEVGATTSLFPYDERMGTYLKATGRE
                     EVAKMAASVAADLRADDEVLANPEKYYDRIIEIDLSLLEPYINGPFTPDAATPISKFAE
                     VVITNNYPRRMEVGLIGSCTNSSYQDLSRAASLARQVKEKNLKVASSLIVNPGSEQIRA
                     TAERDGMIAAFEDIGATIMANACGPCIGQWKRHTDDPERKNSIVTSFNRNFAKRADGNP
                     NTFAYVASPEITMALTIAGDLCFDPLRDTLVNAKGEVVKLSEPVGEELPAHGFIGGKEG
                     YIAPGKGQTEITVNPHSQRLQLLTPFPAWDGMDLLNMPLLIKVQGKCTTDHISMAGPWL
                     RFRGHLENISDNMLMGAVRKRIDAMLNALDERELK"
     CDS             2031..3731
                     /locus_tag="ctg111_2"
                     /transl_table=11
                     /translation="MEYEYEKEEFKRQTENMGVARKVKRGLCWYPATPGRSYYNSLNQL
                     VIEITHTENTDIEHNFEFGRPVCFFRQSADGKITYMNFTATVSYADETRMVAIMPGAGA
                     VMEVQETDNLGVQLYFDETSYRTMFEALEDTLRSKGNRLAELRDILLGTSKAGFRELYP
                     VRFPWLNSTQETAVNKVLCARDVAIVHGPPGTGKTTTLVEAIYETLHREPQVLVCAQSN
                     TAVDWISEKLVDRGVNVLRIGNPTRVNDKMLSFTYERRFENHPLYPELWSIRKNLRELG
                     SRARRGSYDEREGVRSRMSRLRDRATALEIQINSELFDGAHVIASTLVSSNHRLLNGRR
                     FGTLFIDEAAQALEAACWIAIRKADRVVLAGDHCQLPPTIKCYEAARGGLERTLMEKVV
                     SNKPAVVSLLKVQYRMHEEIMKFPSQWFYNGELEAAPEVRYRGILDWDTPIHWIDTSEM
                     DFKEEFVGETFGRINKAEADLLLSELKIYINRIGGNRILEEKIDIGIISPYKAQVQYLR
                     SKIKADAFTQALSQLVHCKYGGWLPRARARCYLHQPCPCQRRRTDRIPE"
     CDS             complement(3926..4969)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg111_3"
                     /sec_met_domain="IlvN (E-value: 3.1e-47, bitscore: 149.3,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 2.8e-41, bitscore: 130.3,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQLNFGGVIENVMTREEFPLEKAREILKDETIAVIGYGVQGPGQ
                     ACNLRDNGFNVIVGQRPGKTYEKAVADGWVPGETLFGIEEACQKGTIVMCLLSDAAVMS
                     VWPTIKPYLTPGKALYFSHGFAITWNDRTGVVPPKDIDVIMVAPKGSGTSLRTMFLEGR
                     GLNSSYAVYQDATGKAFDKTIALGIGIGSGYLFETTFIREATSDLTGERGSLMGAIQGL
                     LLAQYEVLRENGHTPSEAFNETVEELTQSLMPLFAKNGMDWMYANCSTTAQRGALDWMT
                     PFHDAIKPVVQKLYASVKSGNEAQISIDSNSKPDYREKLNAELKALRESEMWQTAVTVR
                     KLRPENN"
     CDS             complement(5020..5772)
                     /locus_tag="ctg111_4"
                     /transl_table=11
                     /translation="MMSENNKIGTYKFVAEPFHVDFTGRLTMGVLGNHLLNCAGFHASD
                     RGFGIATLNEDNYTWVLSRLAVELDEMPYQYEDFSIQTWVENVYRLFTDRNFAIIDKEG
                     KKIGYARSVWAMISMNTRKPADLLALHSGSIVDYVCDEPCPIEKPSRIKVASKEPVAAL
                     VAKYSDIDINGHVNSIRYIEHILDLFPIEMYKEKRIRRFEMAYVAESYYGDELTLFMDD
                     AGEGVYDVEVKKNGSEVVCRSKVIFTEK"
     CDS             complement(5769..6329)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg111_5"
                     /sec_met_domain="ALS_ss_C (E-value: 4.8e-20, bitscore:
                     60.8, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKKLYTIIVHSENFAGLLNQVTAVFTRRQINIESLNVSASSIKG
                     VHKYTITAWTDKDTIEKVTKQITKKIDVLQAHYFTDDEIYQHEIALYKITTPTLEEKPE
                     VSKVIRKYNARIVEVNAVFAIVEKNGMSEEITNLYEELRQLDCVLQFVRSGRVAITTSC
                     FERVNEYLADREAKYRQSKHQES"
     CDS             complement(6362..8113)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg111_6"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.2e-47, bitscore:
                     150.7, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MADNNKKSNFSSLSQGEGRGEALITGAEALMRSLEHQGVKTIFGY
                     PGGSIMPVFDALYDHRKELNHILVRHEQGATHAAQGFARVSGEVGVCLVTSGPGATNTI
                     TGIADAMIDSTPIVVIAGQVGTNFLGTDAFQEVDLVGITQPITKWSYQIRRAEDVAWAV
                     ARAFYVAKSGRPGPVVLDFAKNAQVEKTEYAPTKVDYVRSYLPVPEMEPEAIRKAAELI
                     NGAERPLVLVGQGVELGEAQQELRAFIEKAGMPAGCTLLGLSALPTNHPLNKGMLGMHG
                     NLGPNINTNKCDVLIAVGMRFDDRVTGKLETYAKQAKIIHFDIDPAEIDKNVKTDVAVL
                     GDCKETLAAVTQLLEPANHQEWIDSFRQYEEVEEEKVIRPELHPAGKALSMGEVVRAVS
                     EATHNEAILVTDVGQNQMMSARYFKYSKERSIVTSGGLGTMGFGLPAAIGATFGRPDRT
                     VCVFMGDGGLQMNLQELGTIMEQKAPVKMILLNNNFLGNVRQWQAMFFNRRYSFTPMMN
                     PDYMKIASAYDIPARRVMTREELAKAIDEMIATDGPFLLQACVEEEGNVMPMTPPGGSV
                     NQMLLEC"
     CDS             complement(8205..10007)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ILVD_EDD"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg111_7"
                     /sec_met_domain="ILVD_EDD (E-value: 4.9e-219, bitscore:
                     717.2, seeds: 918, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKHQLRSSFSTQGRRMAGARALWTANGMKKEQMGKPIIAIVNSFT
                     QFVPGHVHLHEIGQFVKEEIEKLGCFAAEFNTIAIDDGIAMGHDGMLYSLPSRDIIADS
                     VEYMVNAHKADAMVCISNCDKITPGMLMAAMRLNIPTVFVSGGPMEAGEWNGQHLDLID
                     AMIKSADESVGDKEVAQIEQHACPTCGCCSGMFTANSMNCLNEAIGLALPGNGTIVATH
                     ENRKKLFEDAAKLIVENAFRYYEEGDESVLPRSIATREAFLNAMTLDIAMGGSTNTVLH
                     LLAVAHEAGADFKMDDIDMLSRKTPCLCKVAPNTQKYHVQDVNRAGGIIAIMNELAKGG
                     LVDTNVRRVDGMTLAEAIDRYSITSPDVCKEAIKKYSSAAAGKFNLVLGSQNASYKELD
                     TDRATGCIRDLEHAYSKDGGLAVLKGNIAQDGCVVKTAGVDESIWKFTGPAKVFDSQDA
                     ACDGILGGKVVSGDVVVITHEGPKGGPGMQEMLYPTSYIKSRHLGKVCALITDGRFSGG
                     TSGLSIGHVSPEAAAGGNIGKIKDGDIIEIDIPNRSINVKLTDEELAARPMTPVTRNRE
                     VSKALKAYASMVSSADKGAVRLID"
     CDS             10497..10784
                     /locus_tag="ctg111_8"
                     /transl_table=11
                     /translation="METVENKYITVAYKLYSIENGEKDFEEEAPVEHPFQFISGLGMTL
                     EPFEAQIKDLQIGDKFDFTIPASEAYGEYDDDHVIDLPKEIFMIEGEFDSD"
ORIGIN
        1 attttcaatt ctctttcgtc caaggcgttc aacatggcat caatccgctt tctgacagcc
       61 cccatcagca tattgtccga aatattctcc aaatgtcccc ggaaacggag ccatggcccc
      121 gccatagaga tgtggtcggt ggtacatttc ccttgcactt taatcaataa aggcatattc
      181 agcaagtcca tgccatccca ggcagggaag ggagtcagca gttgcaagcg ctgtgaatga
      241 ggattgaccg taatttccgt ctgtcctttg cctggagcaa tgtatccttc ctttcctcct
      301 ataaacccgt gtgccggcag ttcttcaccg accggttcgg acagtttcac aacctctcct
      361 ttggcattga ccagcgtatc cctcaacggg tcgaaacaaa ggtcaccggc aatggtcagc
      421 gccatcgtta tctccgggga agcgacgtaa gcaaaagtgt tgggatttcc atcggcacgt
      481 ttggcaaaat tacggttaaa agaggtgacg atggaatttt ttcgttcagg gtcatcagta
      541 tggcgcttcc actggccaat acaaggtccg caggcattcg ccattatcgt tgcgccaata
      601 tcttcgaaag cggcaatcat gccgtcgcgt tcagcagtgg cacgtatctg ctccgaaccg
      661 gggttgacaa tcagcgagga agcaaccttc aaattctttt cctttacctg ccgggcaagg
      721 gaggctgcgc ggctcaaatc ctgataggac gaattggtac acgaccctat caggccgact
      781 tccatccggc ggggatagtt attggttatc actacctcgg caaatttcga tatcggtgtt
      841 gctgcatccg gcgtaaaggg cccgttgata tacggttcca acagcgagag gtctatttca
      901 atgatgcggt cgtaatattt ttccggattt gccagcactt cgtcgtcggc gcgaaggtcg
      961 gcagctacgg aagcagccat ttttgccact tcttcacgtc cggtagcctt caaataagta
     1021 cccatgcgct catcgtaagg gaaaagggag gtagtcgccc ccacctctgc ccccatattg
     1081 cagatggtag cctttccagt ggcagacaat gaagcggttc ccggtccaaa atattcaatg
     1141 atggcattgg ttcccccttt taccgtaaga atacccgcca acttcagaat aacgtctttg
     1201 ggagctaccc agccactcaa tttacccttc aagtgtacac ctatcagaca cggcattttc
     1261 aattcccatt ccatgccagt catcacatcc accgcatcgg caccacccac accaatggcc
     1321 accatgccca aacctccggc attgggcgta tgagagtccg tgcctaccat cattccaccc
     1381 ggaaatgcgt agttctccaa taccacctgg tgaataatgc ctgctcccgg ctgccaaaaa
     1441 cctatgccat agcgggaaga aacatcacgg agaaaattat agacctcctc gttggtcttc
     1501 gtagcagtcg cgatatcttc ttttgcacct ttatatgctt gaatcaaatg gtcacagtgc
     1561 acagtggaag gcacggcaac ctgctcacgg cctgcattca taaattgcaa taaggccatt
     1621 tgggccgttg catcctgcat ggccacacgg tcgggacgga aattcacata gtcttctccc
     1681 cgtctgtagt tcttcacttt atccccatca tacaaatgag catacaaaat tttctccgct
     1741 aaagtcatcg gacgctgtag tacattccgt acgcgttcta tcttctccga ataagcagca
     1801 taaaacgttt tgagcatcgt taaatcatat accataacca ctatttttta gtttttcatt
     1861 attgtaaaga ttacaaatta atatcataaa caaataaaaa ggctgaatag tttaacaaaa
     1921 taaagcattt tttccgtcgg aagcgaagaa tgattacctt tgcaaccatg aaggaacaag
     1981 attcaaatag tcctattatt cacctccagc agcaacaagt tttgctgtgc atggaatacg
     2041 aatacgaaaa agaggaattc aaacgccaaa ccgaaaacat gggagttgcc cggaaagtga
     2101 aacggggact ttgctggtat cctgccactc cgggacgaag ttactataat tcactgaatc
     2161 aattagtaat agaaattaca cacacagaaa ataccgatat agaacataat tttgagttcg
     2221 gccgtcccgt atgttttttc cgccagtctg ccgatggaaa aataacctat atgaacttca
     2281 ccgctaccgt aagctatgcc gacgagacac ggatggtagc gataatgccc ggagccggtg
     2341 ccgtgatgga agtgcaggaa acggacaacc tcggcgtgca actttatttc gacgaaacat
     2401 cctatcggac catgttcgaa gccttggaag atacgttacg ctccaaaggc aaccgcctgg
     2461 ccgaattgcg ggacatattg ctgggaacct cgaaagccgg tttccgagag ctctatcccg
     2521 tacggtttcc ctggctgaac tccacgcagg aaacagctgt aaacaaagtg ctgtgtgctc
     2581 gcgacgtggc cattgtacat ggtcctccag gaaccggaaa aacgaccacc ttagtggaag
     2641 ccatctacga aaccctgcat cgggaaccgc aggtactggt atgtgcccaa agcaatactg
     2701 ccgtcgactg gatttcggaa aaactggtag accgtggcgt caatgtcctg cgtatcggca
     2761 atccgacccg tgtcaacgac aagatgcttt cctttaccta cgagcgtcgt ttcgagaacc
     2821 atccgcttta tccggagctg tggagcatcc ggaaaaatct ccgtgaactg ggcagccgtg
     2881 cccgccgtgg cagctatgac gaacgcgaag gagtacgcag ccgtatgagc cgcctgcgcg
     2941 accgcgccac cgcattggaa atacaaatca attcagagct ttttgatggg gcacatgtca
     3001 tagcctccac gctggtaagc agcaatcacc ggctactgaa cggacgccgt ttcggcaccc
     3061 ttttcattga tgaagcagcc caggccttag aggctgcctg ctggatagct atccgaaaag
     3121 cagaccgcgt ggtattggcg ggtgaccact gccaacttcc gcccaccata aaatgctacg
     3181 aagccgcccg tggaggtctg gaacgaacat tgatggagaa agtggtgtcc aacaaacctg
     3241 ccgttgtctc tttgctgaaa gtacaatacc gcatgcacga ggaaatcatg aaatttcctt
     3301 cccaatggtt ttataatggc gagttggaag ccgctcccga agtgcgttac cggggcatcc
     3361 tggactggga tacccccatc cactggattg acacctccga aatggatttc aaagaagaat
     3421 ttgtgggaga gactttcgga cgcattaata aggcggaagc ggacctgctc ctatcagaac
     3481 tgaaaatcta catcaaccgt atcggtggca accgcattct ggaagaaaaa atagacatcg
     3541 gcatcatctc cccttacaag gcacaagtgc aatatctccg cagcaagata aaggcagacg
     3601 ccttcactca agccttatcg cagcttgttc actgtaaata cggtggatgg cttccaaggg
     3661 caagagcgcg atgttatctt catcagcctt gtccgtgcca acgaagaagg acagatagga
     3721 ttcctgaatg atttaaggag aatgaatgta gccatcaccc gggcacgtat gaagctggtg
     3781 atattgggag aggcagagac gctgaaacat cacggttttt accggaagct attggagttt
     3841 attcaaaata tagggaatca ataataaaga aataccccct ccggtaacac cgaagagggt
     3901 atttcaccta tttatataaa gctgattaat tgttttccgg acgaagttta cgaactgtaa
     3961 cagctgtctg ccacatttcg ctttcacgca aggctttcaa ttctgcattc agcttctcac
     4021 gataatcggg tttggagtta ctgtcgatag aaatctgagc ttcgttgccc gacttcacac
     4081 ttgcatacaa tttctgtaca accggcttga tggcatcatg gaacggggtc atccaatcca
     4141 gcgcaccacg ctgtgccgta gtagaacagt tggcatacat ccagtccata ccgttcttgg
     4201 caaacaatgg catcaaagat tgagtcaact cttccactgt ttcattgaat gcttcagaag
     4261 gagtatgacc gttttcgcgc aatacctcat actgagccaa cagcaatccc tggatagcac
     4321 ccatcaatga accgcgttca ccggtcaagt cggaagtggc ttcgcggatg aaagttgtct
     4381 cgaacaaata tcccgaacca ataccgatac ccagtgcaat cgtcttgtca aaagccttac
     4441 ccgtagcatc ctgatagacg gcatatgatg agttcaagcc acgcccttcg aggaacatgg
     4501 tacgaagtga agtaccggaa cctttgggag caaccataat aacatcaata tctttaggag
     4561 gaaccacgcc ggtacggtcg ttccaggtaa tagcaaaacc atgagagaag taaagagcct
     4621 ttccgggagt caaataaggt ttgatagtcg gccatacaga cattacagct gcgtcagaca
     4681 acagacacat gacgatagta cctttctggc aagcctcttc gatgccgaac aaagtctcac
     4741 ccggtaccca tccgtcagcc accgcctttt cgtatgtctt acccggacgt tgtcctacaa
     4801 tcacattgaa accgttatca cgcaagttgc aagcctggcc cgggccttgt acgccataac
     4861 cgattactgc aattgtttca tctttcaaaa tctcacgtgc tttttccaaa ggaaattctt
     4921 ctcgggtcat tacattctca ataacaccgc caaaattcaa ttgtgccatt ttttgtttta
     4981 atttttattt gtggcttacg ccaacgttga taaatttatt tatttctctg taaatatcac
     5041 tttagagcga cagaccactt cgctgccatt ctttttcacc tccacatcgt aaacgccctc
     5101 accggcatca tccatgaaca aagtcaactc atccccataa tagctttcgg ctacatatgc
     5161 catttcaaaa cgacggatgc gcttctcctt atacatctct atcgggaaca aatcaaggat
     5221 atgctcgatg taacggatgc tgttcacatg cccgttaatg tcaatatcac tgtatttggc
     5281 taccaaagca gcaaccggtt cctttgaggc cacctttatc cgcgaaggtt tttctatcgg
     5341 gcaaggctca tcgcaaacat aatctacaat gctgccacta tgaagagcca gcaaatctgc
     5401 cggcttacgg gtattcatgc taatcatcgc ccaaacggaa cgtgcatacc caatcttctt
     5461 accctcctta tcgatgatag cgaaattacg gtctgtaaaa aggcgataga cattctccac
     5521 ccaagtctga atggagaaat cttcgtactg ataaggcatt tcatccagtt cgacagccag
     5581 acgggacaat acccaagtat aattgtcctc gtttagagtc gcgatgccaa aaccgcggtc
     5641 gctggcatgg aaacccgcac aattcaacaa atggttgccc aatactccca ttgtcagccg
     5701 tccggtaaag tcgacatgaa acggttcggc aacaaacttg taggtaccta ttttattgtt
     5761 ctcgctcatc atgattcctg gtgtttactt tgacgatatt ttgcttcacg gtccgccaga
     5821 tattcattga cacgctcaaa gcagctggtc gtaatggcta cgcgacccga acggacgaac
     5881 tgaagtacgc aatccaactg gcgcaactcc tcataaagat tggttatttc ctcactcatg
     5941 ccattcttct caacaatggc aaatacagca ttcacctcca caatacgggc attgtactta
     6001 cggattactt tggacacctc cggtttttct tccagcgtag gggtcgttat tttataaagg
     6061 gcaatctcgt gctgatagat ttcatcatcc gtgaaataat gggcttgcag cacatctatt
     6121 ttcttggtaa tctgcttggt caccttttca atggtatcct tatccgtcca agcggtaatg
     6181 gtatatttat gtaccccctt gatggaggag gccgatacat tcaaactctc gatgtttatc
     6241 tgccggcggg taaacacagc cgtcacctga ttcagcaaac cggcaaagtt ttccgaatga
     6301 acaatgattg tatatagttt tttatccata gatagagtaa attctttaat ttcgcatgac
     6361 ttcagcattc caacaacatc tgattgaccg aaccgcccgg aggtgtcatc ggcattacat
     6421 ttccttcttc ctccacacaa gcttggagca ggaacggtcc gtcagtcgct atcatctcgt
     6481 caatcgcttt tgccagctcc tcgcgggtca ttaccctgcg tgcaggaata tcatatgccg
     6541 aagcaatctt catataatcc ggattcatca tcggagtaaa cgaataacga cgattgaaga
     6601 acatcgcctg ccattgacga acattgccca ggaagttatt gttcaacaga atcatcttca
     6661 ccggagcctt ttgttccatg atggtaccca gttcctgcag gttcatctgc aagccgccgt
     6721 ctcccatgaa tacgcatacc gtgcggtccg gacgtccaaa agtggcaccg atagctgccg
     6781 gaaggccgaa gcccatagta cccaggccac cggaagtaac aatgctacgt tccttgctgt
     6841 atttgaaata acgggcggac atcatctgat tctggccgac atcagtcacc aatatcgcct
     6901 cgttatgggt agcctcactc acagcacgca ccacctcacc catgcttagc gcttttcctg
     6961 ccggatgtaa ttccggacgg attacctttt cctcttccac ttcctcgtat tgccggaaac
     7021 tgtcaatcca ttcctgatgg ttggcgggtt ccagcaattg ggtaacggca gccagtgtct
     7081 ctttgcaatc tcccaggaca gcaacatcag tctttacatt cttatctatt tcggcagggt
     7141 caatatcaaa gtggataatc ttcgcctgct tggcatatgt ttccaattta cccgtcacac
     7201 ggtcatcaaa gcgcatgcct acggcgataa ggacatcaca tttattggta ttgatattgg
     7261 gccccaggtt accgtgcata ccaagcattc ctttgttcaa cggatggttc gtaggtaatg
     7321 cggaaagtcc caataaagtg catccggcag gcattccggc tttctcaatg aaagcacgaa
     7381 gctcttgctg ggcttctccc agctccacgc cttgtcctac cagcaccaaa ggccgttccg
     7441 caccatttat taattcagca gccttccgta tggcctccgg ctccatttcg ggaacgggaa
     7501 gatagctacg gacatagtcc accttagtag gcgcatattc tgttttctcc acttgggcgt
     7561 ttttagcaaa atccagcacg accggtcccg gacgtccgct ctttgccaca tagaaagcac
     7621 gtgccactgc ccaggccaca tcttctgcac gacgaatctg gtaactccat ttcgtgatag
     7681 gctgagtaat gcctaccaag tccacttcct gaaatgcatc cgtacccaag aagttcgtcc
     7741 ctacctggcc ggcaatgaca acgataggcg tactgtcaat catggcatct gcaatgcccg
     7801 tgatagtatt ggtagcaccc ggtccactgg taaccagaca aacgccaacc tcgcctgata
     7861 cacgtgcaaa gccttgtgcc gcatgggttg ctccttgttc atgacgaacc aagatgtggt
     7921 tcaattcctt ccgatggtcg tataaggcat cgaataccgg catgatgctc cctcccggat
     7981 aaccgaaaat agtctttact ccctgatgct ccagagagcg catcaatgct tctgcgcctg
     8041 ttattagagc ctcaccccga ccctctcctt gggagaggga ggaaaagtta ctctttttat
     8101 tattatcagc catactttat ctattcatta tatttaaaag ctcaatagta gcttgaaaaa
     8161 tttgtttcat tctctcctcc cctcgctttc ggaaaggggg gcttttaatc aatcagcctc
     8221 acagcacctt tgtcagcgga actcaccata ctggcatatg ctttcaatgc tttggagact
     8281 tcgcggttgc gagttaccgg agtcatgggg cgtgcagcaa gctcttcatc cgtcaacttc
     8341 acattaatag aacggttcgg tatatcaatt tcgataatgt ccccatcctt aatcttgccg
     8401 atattaccac cagcagccgc ttcgggagaa acatgtccga tacttagtcc ggaagtacca
     8461 ccactgaaac gcccgtcggt aatcaatgca cacaccttac ccagatggcg ggatttgata
     8521 taagaagtag gataaagcat ctcttgcata cccggtccgc ctttcggccc ttcgtgagtg
     8581 atgacgacga cgtctccact gaccaccttt ccacccagaa taccgtcaca agccgcatct
     8641 tgtgagtcga agactttcgc cggccccgta aatttccaga tactctcgtc tacaccggca
     8701 gtcttgacaa cgcaaccgtc ctgtgctata tttcccttca aaaccgccag accgccatcc
     8761 ttgctgtatg catgttccaa atcacggata caaccggtcg cacggtccgt atcgagttcc
     8821 ttataagacg cattttgtga gccgagtacc agattgaact ttccggctgc cgcactggag
     8881 tatttcttga ttgcctcttt acatacatca gggctggtaa tactataccg gtcgattgcc
     8941 tctgccaacg tcattccatc cacacggcgg acattcgtat cgaccagtcc gcccttggca
     9001 agctcattca tgatggcaat gatgccaccg gcacggttaa cgtcttgtac atgatacttt
     9061 tgggtattgg gagccacctt gcataagcag ggggtcttgc gggagagcat gtcaatgtca
     9121 tccatcttaa aatccgctcc ggcttcgtga gccacagcca acaaatgaag tactgtatta
     9181 gtggaaccgc ccatcgcaat atccagcgtc atggcattca aaaatgcctc gcgggtagca
     9241 atactgcgcg ggagtacact ctcatcccct tcttcataat atctaaaggc attctctaca
     9301 atcaacttgg ctgcatcctc aaacagtttc ttgcgatttt cgtgagtggc tacaatcgtg
     9361 ccgttaccgg gcagtgccaa tccaatcgct tcattcaagc aattcatgga attagcggta
     9421 aacatacctg aacagcatcc gcaagtgggg caggcatgtt gctcaatctg tgccacctct
     9481 ttatcgccca cactttcatc agcagattta atcatggcat caatcaaatc caaatgctgt
     9541 ccgttccatt ccccggcttc catcggaccg cctgaaacaa acacagtcgg tatattcagc
     9601 ctcatagccg ccatcaacat ccccggagta atcttgtcac agttactgat gcaaaccata
     9661 gcatccgcct tatgggcatt taccatatac tccacactat cggcaatgat atctcttgaa
     9721 ggcagggaat aaagcatacc gtcgtgtccc atagcgatac cgtcgtcaat ggcaatcgta
     9781 ttgaactccg cagcaaaaca ccccagtttt tcaatctctt cctttacaaa ctggcctatt
     9841 tcgtgcagat gtacatgccc ggggacgaat tgtgtaaatg aattgactat agcgataatg
     9901 ggcttaccca tctgttcctt cttcatacca ttcgccgtcc acaatgcacg ggctcccgcc
     9961 atgcggcgac cttgtgtgct gaacgagctg cgtaactgat gcttcatttt caaatctcct
    10021 tttaatgaaa aagcctctcc cactatagtg agaaaggctt aataaattat cttctaacgt
    10081 acgaatacat acataacctt tctcacgctc ttgatgccac caccacgacg cgaataatat
    10141 gcaggactgc caggttaata gatgtatgta aattcattac ttaattcttc ttttttgttt
    10201 caaacgtgct gcaaaggtaa gggctttttt ataatctcca aacaaattga agaaaaaaat
    10261 aagataaata tgaataatcg taagaaaata tcgccctaaa atcctatttt atcacttaac
    10321 agttctaaat agaaccattc agacagccaa tgtaaatgta ttgccaatca ttgaaaccat
    10381 ttaataatct gaaaattacc aaaggctctc tacatcccga aacaaataat tcgtatcttt
    10441 gtctcttcaa atactcaaaa aaaagtattt actaattaaa taaagataga aaattaatgg
    10501 aaacagtaga aaacaagtac atcaccgtag catataagct gtactcaatc gaaaacggag
    10561 aaaaagattt cgaagaagaa gcacccgtag agcatccttt tcagtttatc tcaggtctgg
    10621 gaatgacact cgaacccttt gaagcccaga taaaagactt gcagataggc gataaattcg
    10681 actttaccat tccggcatca gaagcttatg gtgaatatga cgacgaccat gttattgacc
    10741 tccccaaaga aatcttcatg atagaaggag aattcgacag cgac
//
