LOCUS       gnlProkkaIHAFMDNN_398  11464 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|IHAFMDNN_398.
ACCESSION   gnlProkkaIHAFMDNN_398
VERSION     gnlProkkaIHAFMDNN_398
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-01 16:11:42
            Original ID  :: gnl|Prokka|IHAFMDNN_398
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 11464
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..11464
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[4361:5735]"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      4362..5735
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
     cand_cluster    1..11464
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /kind="single"
                     /product="ranthipeptide"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..11464
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="ranthipeptide"
                     /region_number="1"
                     /rules="(TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085
                     or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /tool="antismash"
     CDS             91..744
                     /locus_tag="ctg398_1"
                     /transl_table=11
                     /translation="MLQIGIREPGSAITHFIAMMMAIFATSPLLVKAALNGNHTTILAM
                     AVFMGSMVLLYGASTVYHSLVVRDKILKIFRKLDHMMIFVLIAGSYTPVCLIVLGGKSG
                     YTLLAAVWGIAAAGMLIKVLWINCPKWFSSVIYIAMGWVCLFVFRELLATLSQAAFLWL
                     LAGGLIYTVGGVIYALKLPVFNAKHSQFGSHEVFHLFVMAGSICHFVFMYQYVA"
     CDS             865..1743
                     /locus_tag="ctg398_2"
                     /transl_table=11
                     /translation="MRYTLENENLKVEIDSFGAEIKSVKRKSDNFEYMWCGDKKYWGRT
                     SPVLFPFVGAPKNKEYRYDGKTYTMGQHGFARDMEFTLEAQTEENISFVLTDTAETCEK
                     YPFHFALHIGYELCKNEVKVNWTVENTDTKELYFSIGAHPAFNCPVHGEGNKTGYGLKF
                     GGLADTIHHHGNTPDGMAVMEDKVLALKDGCVTFTEGFFDECTYMVEGKQTGEVSLLDR
                     EGIPYVTVKFDTPLFAVWSPEGKNAPFVCIEPWYGRCDATDFTGTLQQRDYENMLPQGG
                     TFKAAYSIAYL"
     CDS             1862..2254
                     /locus_tag="ctg398_3"
                     /transl_table=11
                     /translation="MNIQSKMKTRDAKNNPVTAVLVSVLVMFLLSCLFLLLLAALLYKF
                     DLSESAVKVGIVVIYIVSGVIGGFFMGKIMKTQKFLWGFAAGAIYFCILFLISVLVKQG
                     VSMELPKVATTFILCAASGMAGGMIS"
     CDS             2396..3787
                     /locus_tag="ctg398_4"
                     /transl_table=11
                     /translation="MESQKRQGAEYEFYGKLPLKKAIPLGLQHVLAMFVGNLTPILIIS
                     GACGIAGEEFGSLQVDLLQNAMLIAGIVTLIQLFAIGPVGGKVPIIMGTSSGFIGVFNS
                     VVQVMGGGILAYGAIMCASVIGGLFEGILGFLLKPLRRFFPAVVTGTVVLSIGLSLIAV
                     GVNSFGGGNTANDFGSVENLLLGAAVLLIIVAVKHWMKGMASASSILIGIVAGYIIAAI
                     MGLVLPTTAVNADGVEYTKAWVLNWDKVANAAWFSVPKLMPVKLVFDWRAIIPVLIMFV
                     VTAVETVGDISGVMEGGMGREATDKELSGGVICDGIGSSLAALFGVLPNTSFSQNVGLV
                     TMTKIVNRMALASGAVFLILCGLFPKLAALISIMPQSVLGGAAVMMFSSIVISGIQLIT
                     KEPMTMRNITIVSVALGLGYGIGSSSGILAHLPQGIQLIFGGSGIVPAAIVAIIFNIIL
                     PKDAE"
     CDS             4362..5735
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: Ranthipeptide_rSAM_RRE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR04085"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: Quinohemoprotein_rSAM_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg398_5"
                     /sec_met_domain="Ranthipeptide_rSAM_RRE (E-value: 3.3e-35,
                     bitscore: 109.8, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Quinohemoprotein_rSAM_RRE (E-value:
                     3.1e-11, bitscore: 32.8, seeds: 15, tool:
                     rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 4.4e-17, bitscore: 52.1,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 5.4e-14, bitscore: 42.3,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 7e-19, bitscore: 57.6,
                     seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVHQYKNNGYDIVLDVNSGAIHVVDDVTYDVIEMIDQSQPESYAR
                     DEIVSALSGKYGKEEVEEAIDEVQTLIDEESLFTKDTYENYIMDFKKRPTVVKALCLHI
                     AHDCNLACQYCFAEEGEYHGRRALMSFEVGKKALDFLIANSGNRRNLEVDFFGGEPLMN
                     WQVVKDLVAYGREQEKLHDKNFRFTLTTNGVLLNDEIMEFCNKEMANVVLSIDGRKEIH
                     DKMRPFRKGAGSYDLIVPKFQKFAESRHQDKYYVRGTFTHYNPDFAADVLHLADLGFKQ
                     ISVEPVVAEPSEPYAITEEDLPQLFEEYDKLAAEMVRRHKEGDDFNFFHFMIDLEGGPC
                     VAKRLSGCGSGTEYLAVTPWGDFYPCHQFVGNEKFLLGNVDEGIKNTEIRDEFKCCNVY
                     AKEKCRKCFARFYCSGGCAANAYNFSGDICGAYDIGCELQKKRIECAIMIKAAEADCE"
     CDS             5761..7920
                     /locus_tag="ctg398_6"
                     /transl_table=11
                     /translation="MKKSKAAVILVAILAAFAGLAYYASIILSSTGIGEEMSIPLGLDL
                     SGGVSITYQVMDENPSAEDMSDTIYKLQKRVESYSTEASVYQVGDDRIAVEIPGVTDAS
                     KILEELGNPGSLEFQLSDGTVFMTGDQVADAQAATTTDQYGNKQYVVQLTLTDEGAKTF
                     GEVTSENVGKALPIVYDGEVISYPTVQEAITGGTAQISGQSTFEEAQTLATQIRIGSLS
                     LQLSELESSVVGAQLGSQAISSSLKAAAIGLVIVMVFMIIVYAVPGVAAALALAIYTAL
                     VIATLYLFEITLTLPGIAGIILSIGMAVDANVIIFARIREEIASGKSVITAMKNGFHKA
                     MSAILDGNITTLIAAIVLMGLGSGTVKGFAYTLMIGIILSMFTALVVTRWILYSFYWLG
                     MRDEKFYGRAKERKTINFLQKRYVFFAISIAVIAAGFIGMGVHKASGQNSLNYGLDFMG
                     GTSTTADFGKEYTIEDIENDIIPVVKEVTGDSNIQANKVEGTTQITIKTRTLSKEERDD
                     LNNKLADSFDVDESTITFQSISSTISGEMRADAVKAVIISTICMLIYIWFRFKDIRFGA
                     SAIIALIHDVLVVLTVYALMRISVGNTFIACMLTIIGYSVNDTIVIFDRIRENLALKHG
                     KQTREDLMEVANRSLTQTLSRSINTSITTFIMVFMLFLLGVASIREFALPLMAGMICGA
                     YSSICIATELWYVMKVHLGKNKITE"
     CDS             8106..8384
                     /locus_tag="ctg398_7"
                     /transl_table=11
                     /translation="MDTIAAYLIFLNLVGFLIMGEDKRRAKMHRWRISERMLFLVSILG
                     GSIGTWAGMYVFRHKTRHWYFVIGIPLILILQIAGAIWLYRQGLYHL"
     CDS             8524..9765
                     /NRPS_PKS="Domain: Aminotran_1_2 (77-368). E-value:
                     1.2e-15. Score: 49.4. Matches aSDomain:
                     nrpspksdomains_ctg398_8_Aminotran_1_2.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg398_8"
                     /sec_met_domain="Aminotran_1_2 (E-value: 2.1e-16, bitscore:
                     49.3, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYTLEDIQAVDMEVANAITDEFERQNSHIELIASENWVSKAVMSA
                     MGSVLTNKYAEGYPGKRYYGGCECVDVVEELARERAKELFGCEYANVQPHSGAQANMAV
                     QFAILKPGDTVMGMNLDHGGHLTHGSPVNFSGTYFHIVPYGVNDEGFIDYDKVEEIAME
                     CKPKMIIAGASAYARTIDFKRFREIADACGAVLMVDMAHIAGLVAAGLHPSPIPYAHVV
                     TTTTHKTLRGPRGGMILSSQEIADKYNFNKAIFPGIQGGPLMHVIAAKAVCFKEALQPE
                     FKVYQQNIIDNAQALCKGLLSRDIKIVSGGTDNHLMLVDLTNYDQTGKAVEKLLDSVNI
                     TCNKNTIPNDPKSPFVTSGVRLGTPAVTSRGLNTEDMDQIAEAIAMMIKEGEPAADKAC
                     AIVKSLTEKYPLER"
     aSDomain        8755..9627
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg398_8_Aminotran_1_2.1"
                     /evalue="1.20E-15"
                     /label="ctg398_8_Aminotran_1_2.1"
                     /locus_tag="ctg398_8"
                     /protein_end="368"
                     /protein_start="77"
                     /score="49.4"
                     /tool="antismash"
                     /translation="RERAKELFGCEYANVQPHSGAQANMAVQFAILKPGDTVMGMNLDH
                     GGHLTHGSPVNFSGTYFHIVPYGVNDEGFIDYDKVEEIAMECKPKMIIAGASAYARTID
                     FKRFREIADACGAVLMVDMAHIAGLVAAGLHPSPIPYAHVVTTTTHKTLRGPRGGMILS
                     SQEIADKYNFNKAIFPGIQGGPLMHVIAAKAVCFKEALQPEFKVYQQNIIDNAQALCKG
                     LLSRDIKIVSGGTDNHLMLVDLTNYDQTGKAVEKLLDSVNITCNKNTIPNDPKSPFVTS
                     GVRLGTPAVT"
     CDS             complement(9854..10678)
                     /locus_tag="ctg398_9"
                     /transl_table=11
                     /translation="MKLFKQITCAVLTLCLCAGLLLIPSAPVSAATGPSAPKAVDVSYY
                     KNYPMVNDSAISVQLGTNGKNIKNIKTSSKNLKAKVTRLSLSSSSNSGYVGVYAKKTGK
                     YTVSFDVYNAQNKKIKKFTVKVNVTEPTFSNNSPFKSVTFNNKEYDYAKAVYNKNSVKV
                     NVKMNKGYKLKKIEYSTYSKPVAKTNSSYSTTYSNSEITKKVKNGKSIQLGHYGYYYGH
                     DYSYAYGTYSYESYSRDGDIMAPTIVKITYLDKNKNTISTSYTLYRIADDVK"
     CDS             complement(10700..11335)
                     /locus_tag="ctg398_10"
                     /transl_table=11
                     /translation="MKIFKRTVSLFLAFCLCAGMLLLQPQSTVSAAVRNKPTTTVLRMS
                     SNSFDSSAIYVNLPKAKVCYIKNIKTSSKNLIAKNTHYYTTSSDDTYTDTFASIGLYAK
                     KTGKYKVTYNICDKSGNKLSSGKVTVYVKNDLPVKSVKFAGKEVVKTMKNNSTLKLGEY
                     AYIFDNSYSSGRNYSTSLAARTKITITYIDKYTKQECESIYSISRLAK"
ORIGIN
        1 ataagtagta gtatcaaaat acaaaagata tagtaacaaa tactacatgt aaaaataata
       61 aatactattt tgctaaaagg aggtcacatt atgttacaga tagggattcg tgaaccggga
      121 agcgccatta cacattttat agctatgatg atggcaatat ttgccacatc gccgttgtta
      181 gtcaaggctg cgctgaatgg aaatcataca acgattctgg caatggccgt gtttatggga
      241 agcatggtgc tgctttatgg tgcaagtacg gtgtaccatt cgcttgttgt ccgggataaa
      301 attttaaaga tattccgcaa actcgaccat atgatgatat ttgtcctgat tgccggatct
      361 tatacgccgg tatgtctgat cgtacttggc gggaagtcgg gttatacgct gcttgcggca
      421 gtttggggca ttgcggcggc aggaatgctg ataaaagtgc tctggatcaa ctgcccgaag
      481 tggttttcat ccgtgatcta tatcgcaatg ggatgggtgt gtctgtttgt attccgggaa
      541 ctgttagcca ctctttccca ggcagcattt ttgtggctgc ttgcaggcgg tctgatctat
      601 actgtcggcg gtgtgatcta tgcattaaaa ctgccggtgt tcaacgcgaa gcacagtcag
      661 tttggctccc atgaagtatt tcatctgttt gtcatggctg gaagcatctg ccattttgta
      721 ttcatgtatc agtatgtagc gtgaaaaata aaacgattgc cggatagatt ttatggaaaa
      781 gttaggttat aatgtaacag caatgaaaaa tgagcagtga caggcagatg agaaatgaaa
      841 tgcctgtatg aagaggagac agatatgaga tatacgttgg aaaatgaaaa tttaaaagtg
      901 gagattgact catttggagc agagatcaaa tctgtaaaaa gaaaatcaga taactttgaa
      961 tatatgtggt gtggtgataa aaagtactgg ggcagaacat cccctgtatt atttccgttt
     1021 gtcggtgcgc cgaaaaacaa agaataccgt tatgacggaa aaacttatac gatgggacag
     1081 cacggatttg caagagatat ggagtttaca ttagaggcac agacggaaga gaacatctca
     1141 tttgtactga ccgatactgc ggaaacctgt gaaaaatatc catttcattt tgcactgcac
     1201 attggttatg aattgtgcaa aaacgaggtg aaagtaaact ggactgtgga aaacaccgac
     1261 acaaaagaat tatatttttc catcggtgca catccggcat tcaactgccc ggttcacgga
     1321 gagggaaata aaaccggata tggtctcaaa tttggcggcc tggcagatac tattcatcat
     1381 catggaaaca caccggacgg tatggcggtg atggaggata aagtcctggc actgaaagat
     1441 ggctgtgtga catttacgga aggattcttt gatgagtgca cttacatggt cgaaggaaaa
     1501 cagaccggag aggtttccct gcttgaccgt gaaggcatcc cgtatgtaac cgtaaaattt
     1561 gacactccac tatttgcagt atggtcaccg gaaggaaaaa atgcaccttt cgtctgcatt
     1621 gaaccatggt atggaagatg cgatgccaca gattttaccg gcacattgca gcagcgcgac
     1681 tacgaaaaca tgctgccgca gggcggaaca ttcaaggcag cttatagtat tgcatatctg
     1741 taagatagag tcagcaaaag gtggatcata aaaataaaaa acgcaaaagc atgtaaaaaa
     1801 agcatagctt ttgcgttttt ttcatatagt gaaacagaat cgaaaacctg tggagtggtc
     1861 aatgaatata cagtcaaaaa tgaaaacaag agatgcaaaa aacaatccgg tcactgcggt
     1921 attggtgtcc gtgctggtca tgttcctttt aagctgcctg ttcctgttac tgttggctgc
     1981 actgttatat aagtttgatc tgagtgaatc ggcagtaaag gtgggaatcg ttgtcattta
     2041 tatcgtctcc ggagtgatcg gtggattttt catgggaaag atcatgaaaa cacagaaatt
     2101 tttatgggga tttgcagcgg gagccattta tttttgcatt ttattcctga tatcagtgct
     2161 ggttaaacag ggagtctcca tggaactgcc gaaagtggcg acaacattta ttctatgtgc
     2221 ggcatccggg atggcgggcg gaatgataag ttagtggtta ctgtcagtgt gccaattagt
     2281 atatagacag gacttgcgca gaatatcagc ggcgtgctat actcaaagaa aatgtgcatg
     2341 gatgaaaaaa atatcaatgt ttcatgcaga aaaagataca cacgaggagg aagatatgga
     2401 aagtcagaag agacagggag cagagtacga gttttacgga aaactcccgc tgaaaaaggc
     2461 aatcccgctg ggattacagc atgtgctggc aatgtttgtg ggaaacctga caccgatcct
     2521 gatcatctca ggggcatgtg gtattgcagg tgaggagttc ggcagtctgc aggtcgatct
     2581 gctgcagaat gcgatgctga tcgccgggat cgtgacactg atccagttat ttgcgatcgg
     2641 accggttggt ggaaaggtac cgatcatcat gggaacgagt tccggattta tcggtgtgtt
     2701 taacagtgtg gttcaggtaa tgggaggagg aatccttgca tatggagcca ttatgtgtgc
     2761 atccgtcatt ggtggtctgt ttgagggaat ccttggattt ctgttaaagc cgctccgcag
     2821 atttttccct gcggttgtaa cgggaaccgt tgtactgtcg atcggattgt cactgatcgc
     2881 ggtcggcgtc aattcttttg gcggcggcaa tacggcaaac gactttggtt cagtagaaaa
     2941 tttactgctc ggagcagctg ttttactgat cattgtagcc gtgaaacact ggatgaaagg
     3001 tatggcgagt gcatcatcga tcctgatcgg tattgtggca ggctatatca ttgctgcgat
     3061 catgggactg gtactgccga caacagcagt caatgcggat ggtgtggaat acacaaaagc
     3121 ctgggtgtta aactgggata aggttgcaaa tgcagcctgg ttttccgttc cgaaattaat
     3181 gccggtcaaa ctggtatttg actggagagc aatcattccg gttctgatca tgtttgttgt
     3241 taccgcggtt gaaacagtcg gagatatctc cggtgttatg gaaggtggaa tgggcagaga
     3301 agctaccgac aaagaacttt ccggcggtgt catctgtgat ggaattggtt cttcgcttgc
     3361 agcacttttt ggtgttctgc cgaatacttc tttcagtcag aatgtaggac ttgtcacaat
     3421 gacgaaaatc gtaaaccgta tggcgcttgc atccggagcc gtattcctga ttttatgtgg
     3481 tttattcccg aaacttgcag cactgatttc aatcatgccg cagagtgtac ttggaggagc
     3541 tgccgttatg atgttttcat ccatcgtgat cagcggaatc cagcttatta ccaaagaacc
     3601 gatgacgatg cgcaatatca cgatcgtctc cgtcgcattg ggacttggct atggaatcgg
     3661 atccagcagc ggcatccttg cacatctgcc gcagggcatc cagctgatct ttggcggttc
     3721 cggtattgtt ccggcagcca ttgtggcgat catctttaat attatcctgc cgaaggatgc
     3781 ggaataaaaa aaacttccca tatgaaaaaa gttatgttat actgtataag ttaacagaac
     3841 tccgcgcgaa agcgaataaa tacatagtat tacggggagc gggcaaatgg cgtatcccat
     3901 gtgtgcggaa attacaaaaa aggagagaag catcatgaaa catgtaaaga cattaaatac
     3961 caagagatta cagaacacaa tcaaaaaagg cggctgcggc gagtgccaga catcctgcca
     4021 gtctgcatgc aaaacatcct gtacagtagg aaaccagagc tgcgagcaca aataagattt
     4081 gagctggtac agccgggcat gcatagcatg gtaaaaattg tgcatatgag tgccggatat
     4141 gccatcatgg catcatacaa aatgactgtg tgatacaacg atgaaaatca tacggtcgta
     4201 tataagtgaa atctgcaaac gaccgttcgc atagcgtgcg gtcatttgta cgttttatcg
     4261 gcaacattaa aatgccgtaa tacttgaaaa aaatatattg atttgcagaa aactttaaat
     4321 gttttgctgt aaaatcagat agaaagagag gaaatattat agtggttcat cagtataaga
     4381 acaacggcta tgatattgtt ttagatgtaa acagcggagc gattcatgtg gtggatgacg
     4441 tgacttatga tgtcattgag atgatcgatc agagccagcc ggaatcgtat gcaagggatg
     4501 agatcgtatc tgcactgtcc ggaaaatacg gcaaagagga agtggaggaa gcaatcgatg
     4561 aagtccagac attgatcgat gaggagtcac tttttacaaa ggacacttac gaaaactata
     4621 tcatggattt caaaaaacgc ccgacggttg tcaaggcact ctgcctgcat attgcacatg
     4681 actgcaacct ggcatgtcag tactgctttg ctgaggaggg agagtaccat ggaagaaggg
     4741 cactgatgtc ctttgaagtt ggaaagaaag cactggattt cttaattgcc aattcaggta
     4801 acagacgaaa tcttgaggtg gatttctttg gcggcgagcc gcttatgaac tggcaggtcg
     4861 taaaagactt agttgcctat ggaagagagc aggaaaagct gcatgacaag aatttccgtt
     4921 ttacactgac cacaaatggt gtgcttttaa atgacgagat catggaattc tgtaataaag
     4981 agatggcaaa tgtggtctta agtatcgatg gaagaaagga aattcatgat aagatgcgtc
     5041 cgttccgcaa aggggcagga agttatgatc tgatcgttcc aaagttccag aaatttgcag
     5101 agagcagaca tcaggacaaa tattatgtgc gtggtacatt cacacactac aatcctgatt
     5161 ttgcagcaga tgtacttcat cttgcggatc ttggtttcaa acagatctcc gtggagccgg
     5221 tagttgcaga accgagtgaa ccgtatgcga tcacagagga agatcttcca cagctgtttg
     5281 aggaatatga caaacttgca gcggagatgg taagacgtca caaagaggga gatgatttta
     5341 atttcttcca ttttatgatc gatcttgagg gcggtccatg tgtggcaaaa cgtctgtccg
     5401 gctgtggttc aggaaccgag taccttgcag tgacaccatg gggagatttt tatccatgtc
     5461 accagtttgt cggcaatgaa aagtttttac ttggcaatgt ggatgaaggt ataaaaaata
     5521 cagagatccg tgatgagttt aagtgctgta atgtctatgc aaaagaaaaa tgcagaaaat
     5581 gtttcgcaag attctactgc agcggcggat gtgcagcaaa tgcgtataat ttcagcggtg
     5641 acatctgtgg ggcatatgat atcggatgtg aattgcagaa aaaacgtatt gagtgcgcga
     5701 tcatgattaa ggctgccgag gccgattgtg aataaataag aaacaggaag gaaaaagaaa
     5761 atgaaaaaga gtaaagcagc agtcatatta gttgcgattc tcgctgcatt tgcgggactt
     5821 gcctattatg catctattat tctttcatcg accggtattg gggaagaaat gagtattccg
     5881 cttggacttg atctgtccgg tggtgtatcg atcacctatc aggtcatgga tgaaaatccg
     5941 agtgcagagg atatgagtga tacgatttac aaactccaga agcgtgtgga aagttacagt
     6001 acagaggcat ccgtatatca ggttggagat gatcgtatcg ccgttgagat cccgggtgtt
     6061 acggacgcaa gcaagatttt ggaagaactt ggtaatccgg gttccttaga gttccagctt
     6121 tcagatggta ccgtatttat gacgggtgac caggtggcag atgcacaggc tgcaacaacc
     6181 acagatcagt atggaaacaa gcagtatgtg gtacagctta cactgacaga tgagggagca
     6241 aagactttcg gagaagttac ttctgaaaac gtcggaaaag cacttccaat cgtatacgat
     6301 ggagaagtta tcagttatcc gactgttcag gaggcaatta ccggaggtac tgcacagatt
     6361 tccggtcaga gcacctttga agaggcacag actttagcaa cacagatcag aatcggttct
     6421 ctttccctgc agttatcaga gttagagtcc agtgtggtag gagcacagct tggaagccag
     6481 gcaatctcct ccagtttaaa agcggcagca atcggtcttg tgatcgtaat ggtatttatg
     6541 atcattgtat atgcagttcc gggtgtcgca gcagctttag cacttgcaat ttatacagca
     6601 cttgtgattg caactttata cttattcgag atcacattaa cattacctgg tattgccggt
     6661 attatcttaa gtattggtat ggcagtggat gcgaacgtta tcatctttgc acgtatccgt
     6721 gaagaaattg catcaggaaa atccgtgatt actgcaatga agaatggttt ccacaaagcg
     6781 atgtctgcaa tcttagatgg taatatcaca acattgattg cagcgattgt tcttatggga
     6841 ttaggttccg gtactgtaaa aggatttgca tatacactga tgatcggtat tatcctttcc
     6901 atgtttacag cacttgttgt cacaagatgg atcctttatt ctttctactg gttaggaatg
     6961 agagatgaaa aattctacgg acgtgcaaaa gagagaaaga cgatcaattt cctgcagaag
     7021 agatatgtat tctttgcaat ttctattgca gttatagctg ccggatttat cggtatggga
     7081 gtacataagg catctggtca gaactccctg aattatggac ttgacttcat gggaggaact
     7141 tccactactg ctgatttcgg caaagaatat acgatcgaag atattgaaaa tgatattatc
     7201 ccggttgtaa aagaagtaac tggagacagc aatattcagg caaacaaagt agagggaaca
     7261 actcagatta cgatcaagac acgtacttta tccaaagaag agcgtgatga tctgaataat
     7321 aagctggcag acagttttga tgtagatgaa tccaccatta cattccagag tatcagttcc
     7381 acgatcagtg gtgagatgcg tgcggatgca gtcaaggcgg ttattatctc aacaatctgt
     7441 atgctgatct atatctggtt ccgttttaaa gatatccgtt tcggtgccag tgcgatcatt
     7501 gccctgatcc acgacgtact ggttgtactt accgtatatg cgctgatgcg tatttcagtc
     7561 ggcaatacat ttatcgcatg tatgctgacg atcattggtt attctgtcaa cgatacgatc
     7621 gttatctttg accgtatccg tgagaacctt gcattaaagc atggtaaaca gacaagggaa
     7681 gatctgatgg aagtagcaaa ccgaagcctg acacagacct tatcacgaag catcaacaca
     7741 tccataacaa catttattat ggtatttatg ctgttccttc ttggtgtagc aagtattcgt
     7801 gaatttgcac tgccgctgat ggcaggtatg atctgcggtg catattcatc tatctgcatt
     7861 gcaaccgagt tgtggtatgt gatgaaagtt catcttggta aaaataaaat aacagaataa
     7921 gatctgttga agaaaagtga aagtcctggc agttatttgc cgggactttt aagattcata
     7981 ggaaattacg tcctatgaat cttaaagccc tccgggcggg atcacactgc gtcggagatg
     8041 aattatgtcg cgcaggcggt gaatcctgta gaacaggatt ctattttaga aaaaaggaga
     8101 aacatatgga tacgatcgca gcttatctga tctttttaaa tctggtgggc ttccttatta
     8161 tgggagagga taaaagaagg gcgaaaatgc atcgatggcg gatctcagaa agaatgcttt
     8221 ttttagtcag cattttaggc ggcagtatcg gaacgtgggc gggaatgtat gtgttccgcc
     8281 acaagacgag acactggtat tttgttatag gaataccact gatcctcatt ttacagatcg
     8341 caggtgccat ctggctttat cgtcagggct tatatcattt ataataattt gatataacta
     8401 ttctggcatt tggaattgcc aaaaaaagga aagtcatata taatgataaa catagcaaaa
     8461 gacaagtgtt tttcgtagaa agacacattg atcaaacagc aaagaaaggg agaattacgg
     8521 attatgtata cactggaaga tattcaggca gttgatatgg aagtggcaaa tgccatcacc
     8581 gatgaatttg aacgtcagaa cagtcatatt gagctgattg catccgaaaa ctgggtaagc
     8641 aaggcagtga tgtcggcgat gggcagtgtt cttacaaata aatatgcaga aggttatccg
     8701 gggaaaagat attacggcgg atgtgagtgt gtggatgttg tagaggaact tgcaagagag
     8761 cgtgcgaaag agctgtttgg ctgtgagtat gcgaacgtac agccacattc aggtgcacag
     8821 gcgaatatgg ctgtacagtt tgccatctta aaaccgggtg acacggtcat gggaatgaac
     8881 ttagatcacg gcggacattt gacacacgga agccctgtaa acttttccgg tacttatttt
     8941 cacattgtac cttacggtgt caatgacgag ggatttattg attatgacaa agtagaagag
     9001 atcgcgatgg agtgcaagcc gaagatgatc atcgcaggtg caagtgctta tgcgagaacc
     9061 attgatttca agagattccg tgagatcgca gatgcatgcg gagcagttct gatggtcgat
     9121 atggcacata tcgcaggact tgtcgctgca ggacttcatc caagcccaat cccgtatgca
     9181 cacgttgtca caaccacaac acacaagaca ctgcgtggac cgcgtggagg catgatctta
     9241 tccagtcagg aaatcgcaga caaatataac tttaacaaag ctattttccc tggaatccag
     9301 ggcggacctt tgatgcatgt gattgctgcg aaggcagtct gctttaaaga ggcacttcag
     9361 ccggagttta aagtatacca gcagaatatc attgacaatg cacaggcact ctgcaaggga
     9421 ctgttaagcc gtgatattaa aatcgtatcc ggcggtacag acaatcacct gatgcttgtt
     9481 gatctgacaa attatgatca gaccggaaag gcagtggaga aacttctcga ttctgtcaat
     9541 attacctgca acaagaatac gatcccgaac gatccgaaat ccccattcgt aacaagcggt
     9601 gtacgtcttg gaacgccggc agttacttcc cgtggactaa acacagagga tatggatcag
     9661 attgcagagg caatcgccat gatgatcaag gagggtgaac cggcagctga taaagcgtgt
     9721 gcaatcgtaa aatcgctgac agagaaatat ccgctggaga gataaaagag aatagaatat
     9781 aatttaataa tgaataaaaa atgaggaacc tgtttcgtga caggttcctc gttttttgtg
     9841 ctttttgagt ttgttatttt acatcatctg caatacggta cagtgtgtac gaggtagaaa
     9901 tcgtattttt atttttatcg agatatgtga ttttcacgat tgtcggtgcc ataatatcac
     9961 catcacggct gtatgactca taagagtaag taccatatgc gtaagagtag tcatgtccgt
    10021 aatagtatcc ataatgtcct aactggatac tctttccatt ttttaccttt tttgttatct
    10081 cggagtttga ataagtggtt gaataggaag aatttgtttt tgcaactggc ttgctgtaag
    10141 tagagtattc gatcttcttt aatttataac ccttgttcat tttgacattg actttgacag
    10201 aatttttatt gtagactgcc tttgcgtaat catattcttt gttgttaaaa gttacactct
    10261 taaaaggact attgttagag aatgtcggct cggttacatt gactttgaca gtaaattttt
    10321 taatcttttt attctgtgca ttatatacat caaaagatac tgtgtattta ccggttttct
    10381 tggcatagac accaacgtat ccggaattac tggagctgga aagtgaaagt cttgttactt
    10441 tggctttcag gtttttgctc gatgttttga tatttttgat gttttttccg tttgtaccga
    10501 gctgtacgga gatagccgaa tcattgacca tcggataatt tttgtaataa gaaacatcta
    10561 cagcctttgg ggcgcttgga cctgttgcag cagataccgg cgcagaaggg atcagtaata
    10621 atccggcgca caggcaaagt gtaagaacag cgcaagtaat ttgcttaaat aatttcatat
    10681 cagatatcct cctgttggat tattttgcaa gacgggaaat ggaataaata ctctcacatt
    10741 cctgcttggt atatttgtcg atataagtaa tagtgatctt ggtacgcgca gcaagtgagg
    10801 tagaatagtt tctgccgctg gaatatgaat tatcaaatat atatgcgtac tcgccaagct
    10861 ttaaggtgct gttgtttttc attgttttta caacttcttt acctgcaaat ttgacagatt
    10921 tgactggcag gtcatttttt acatatactg ttactttacc cgaagaaagt ttgtttcctg
    10981 atttatcgca gatattatag gtgactttgt atttaccggt ttttttggca tagaggccga
    11041 tagacgcaaa ggtatccgtg tatgtatcgt ctgaactggt agtataatag tgggtgtttt
    11101 ttgcaatcag atttttactg ctggttttga tgtttttgat ataacatact ttggcttttg
    11161 gcagattgac atagattgca gaactgtcga aagaattact ggacatgcga agtacagtgg
    11221 tggtcggttt gttcctgacg gctgcggata ccgttgactg cggctgcagt aaaagcatcc
    11281 cggcacagag acagaaagct aaaaataagc tgactgttcg tttgaaaatt ttcataagtg
    11341 aatcctcctt gtttataaat attttataga tgttacaaaa acattacaat atgaagggaa
    11401 attttataca atcataaatt aaaaaataaa taagggaatt ttaagaaaat ttatagcatt
    11461 atat
//
