LOCUS       gnlProkkaECONCMOK_114  13936 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|ECONCMOK_114.
ACCESSION   gnlProkkaECONCMOK_114
VERSION     gnlProkkaECONCMOK_114
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-01 16:04:40
            Original ID  :: gnl|Prokka|ECONCMOK_114
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13936
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13936
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[909:3339]"
                     /cutoff="0"
                     /detection_rule="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      910..3339
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="0"
                     /detection_rule="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS-like"
                     /protocluster_number="1"
     cand_cluster    1..13936
                     /SMILES="NC([*])C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /kind="single"
                     /product="NRPS-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13936
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="NRPS-like"
                     /region_number="1"
                     /rules="cds((PP-binding or NAD_binding_4) and (AMP-binding
                     or A-OX))"
                     /tool="antismash"
     CDS             complement(12..905)
                     /locus_tag="ctg114_1"
                     /transl_table=11
                     /translation="MQTENFTLGKKELLILLGLTLVLPFPINWALIELNPLTLMAGADD
                     VPTWIGFGGSYIGGIIGGVISIMILNKTLQQTGVLHHDLKLLQLDTIIYTQQQDWFTGF
                     KQELAENLKSIDLYVLNTVVSSISMKNYAYAKEVLTEINKGLEYQMVAASFSFTSTHLS
                     SEEKKYMNLVRRVQTEYSSFIKDILYYIPLAETISSRKKLNYDQLMDYTLSQYDYLQGQ
                     EGESTASGAIIPRVMEIDPSDDIRKELERIMEERLTGRTYLYHLKSDLAEATHQLIIYE
                     ENRINSILHKPEREMN"
     CDS             complement(910..3339)
                     /NRPS_PKS="Domain: AMP-binding (12-401). E-value: 8.6e-83.
                     Score: 270.0. Matches aSDomain:
                     nrpspksdomains_ctg114_2_AMP-binding.1"
                     /NRPS_PKS="Domain: PP-binding (509-568). E-value: 2.7e-10.
                     Score: 32.6. Matches aSDomain:
                     nrpspksdomains_ctg114_2_PP-binding.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: AMP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     256.4; E-value: 7.1e-78)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg114_2"
                     /sec_met_domain="AMP-binding (E-value: 1.5e-87, bitscore:
                     283.1, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 4.8e-11, bitscore:
                     32.6, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTNIQENLSRSLSTWGDKPAVVAKDGTVSYQMLERYSANIAQSI
                     RQRLSVTDPSGLRNICIGVCMERNKTLVPAILAIFRLGATYLPIDPSLPDNRKRYMAEN
                     ADMVLLLTDSSNEVGGIPSVRRLYLNGEQLSEPVVGDYTEVLPDDCAYIIYTSGTTGNP
                     KGVRISYRNLDTFTRNLVDKKLYHLSDPANRYLAFASISFDASILELMMCIPVGGTLIL
                     AGEDERRDISLLDELIRREKVNIAFFPPSLLGMFADLDFPSFKTLLFGAEAIGEKLFNR
                     LKQQPYRLMNVYGPTENTVLSTIRIVGKDTSYDDIGYPLKGTVCYVLSENLQQTTLEAT
                     GELCLGGPQVSLGYIGSVQLNEKSFISYDGERLYRTGDLVQQQPDGSIRFIGRKDTQVK
                     IRGFRIELTEIAERLNRDPDVERAHVVVVERNGRQLLGAYLQPSVSGNFHPEEVKERLR
                     AELPYYMIPNLWQVVDHFQRTINDKIDVRALPAFTSLELKYVPPVHPGEVILCGILKEM
                     LGLPQVSVEADLIDDLGLTSLDMLRLVTEANKKGCPINVSAVYTARNLRRLLLVPRQEP
                     IYWYRQQNLKKPVIILVCGSAYFNHLYFNLADRLYPKYDFLVVDAIYDHFNKVATDIPE
                     LLEYYVRTVQPMIRERTVYALTGFCMGAELAIGLAEMLHRSMGIMPKVFALDGQAWQNP
                     ALCQNYPLLVFPGDTDEMVRERNEIINIYFRTTPNLIYQGEVIVLLSGLFHQQAGLSPE
                     ESWTEENYRIFRTEYDNCERLWNKYYPNAPVLRLPADHWHFLEGESLEQLITVFLK"
     aSDomain        complement(1636..1812)
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg114_2_PP-binding.1"
                     /evalue="2.70E-10"
                     /label="ctg114_2_PP-binding.1"
                     /locus_tag="ctg114_2"
                     /protein_end="568"
                     /protein_start="509"
                     /score="32.6"
                     /tool="antismash"
                     /translation="LCGILKEMLGLPQVSVEADLIDDLGLTSLDMLRLVTEANKKGCPI
                     NVSAVYTARNLRRL"
     aSModule        complement(1636..3303)
                     /complete
                     /domains="nrpspksdomains_ctg114_2_AMP-binding.1"
                     /domains="nrpspksdomains_ctg114_2_PP-binding.1"
                     /locus_tags="ctg114_2"
                     /monomer_pairings="X -> X"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       complement(2110..2172)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg114_2_0004"
                     /evalue="1.50E-11"
                     /label="NRPS-A_a8"
                     /locus_tag="ctg114_2"
                     /protein_end="410"
                     /protein_start="389"
                     /score="36.2"
                     /tool="antismash"
                     /translation="FIGRKDTQVKIRGFRIELTEI"
     aSDomain        complement(2137..3303)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg114_2_AMP-binding.1"
                     /evalue="8.60E-83"
                     /label="ctg114_2_AMP-binding.1"
                     /locus_tag="ctg114_2"
                     /protein_end="401"
                     /protein_start="12"
                     /score="270.0"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="LSTWGDKPAVVAKDGTVSYQMLERYSANIAQSIRQRLSVTDPSGL
                     RNICIGVCMERNKTLVPAILAIFRLGATYLPIDPSLPDNRKRYMAENADMVLLLTDSSN
                     EVGGIPSVRRLYLNGEQLSEPVVGDYTEVLPDDCAYIIYTSGTTGNPKGVRISYRNLDT
                     FTRNLVDKKLYHLSDPANRYLAFASISFDASILELMMCIPVGGTLILAGEDERRDISLL
                     DELIRREKVNIAFFPPSLLGMFADLDFPSFKTLLFGAEAIGEKLFNRLKQQPYRLMNVY
                     GPTENTVLSTIRIVGKDTSYDDIGYPLKGTVCYVLSENLQQTTLEATGELCLGGPQVSL
                     GYIGSVQLNEKSFISYDGERLYRTGDLVQQQPDGSIRFIGRKDTQVKIR"
     CDS_motif       complement(2245..2325)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg114_2_0003"
                     /evalue="1.50E-07"
                     /label="NRPS-A_a6"
                     /locus_tag="ctg114_2"
                     /protein_end="365"
                     /protein_start="338"
                     /score="23.7"
                     /tool="antismash"
                     /translation="ATGELCLGGPQVSLGYIGSVQLNEKSF"
     CDS_motif       complement(2833..2889)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg114_2_0002"
                     /evalue="1.50E-08"
                     /label="NRPS-A_a3"
                     /locus_tag="ctg114_2"
                     /protein_end="169"
                     /protein_start="150"
                     /score="26.8"
                     /tool="antismash"
                     /translation="AYIIYTSGTTGNPKGVRIS"
     CDS_motif       complement(3070..3111)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg114_2_0001"
                     /evalue="3.50E-03"
                     /label="NRPS-A_a2"
                     /locus_tag="ctg114_2"
                     /protein_end="90"
                     /protein_start="76"
                     /score="11.0"
                     /tool="antismash"
                     /translation="LAIFRLGATYLPID"
     CDS             complement(3352..5718)
                     /gene_functions="transport (smcogs)
                     SMCOG1082:TonB-dependent siderophore receptor family
                     (Score: 167.8; E-value: 9.2e-51)"
                     /gene_kind="transport"
                     /locus_tag="ctg114_3"
                     /transl_table=11
                     /translation="MKRCLLYILCCFGVVQLSAQPADNIRNSFVKAETFYKSGDIDEAC
                     RILEENLSSFQGTMHTEACRLAALCCLALDRFPEAEKYVSLLLKDEPYYYISLQDPERF
                     ADMVRKHRETKVTLVTASQQVETPEEAPVPVTLITEEMIRAIHARCLRDVLIAYVPGIS
                     GLSSNEEMNLAMRGVYSPEQENILIMQDGQRLNSYITNAVSPDYGISLAKVKQIEVLRG
                     PASSLYGSVALTAVINIVTKDGVDVRNGSISVSAGNRGQLAADLLLGKHDMNMDFMAWF
                     SLYRATGESVFVPAEKQYALYPRDGFIRLDNYSGFPAMDGGIKLQRGNLLFSFSMNYAK
                     KRQPYSMWLFSSPYSYERFRTFDGSGPGYSRWSAREQAVYSRTWQRITFSTAFYTDWNK
                     NVHYETSGDTLQDYPIFPNYDYQPIIYPTRGAFQYIRWMDFNVGFNGRVNYAYDWGKLG
                     KGNMLGGVEWNRYTLYDSEYLEGMNFKEIVRTWIEKRLYTGHEMNTDAFLQIKHNLHKN
                     WIVNAGIRYDYKRRSNKRTLQAFSPRLSLIYLRNGLNIKASYSRAFVDAPYYYRNNEMD
                     TYSGGENLQAEYLSSYQVTCAYHHSPSHIDVECNLFYNRASHFLFTQPETRVYENAGSL
                     DMGGVEVVARYKADRLSLDGNLCFQKVLNYTNFFVTDGSVNNVPGFSMNLVANYFLLKK
                     KVQSWSAHLKLNCSSHCYTQVSVLEDGLNGDATNYTVRLPGYAVFSFTTRYKYKRIEGS
                     LGIENLFNNRYECGGATVPIRQKGRWISASILYNF"
     CDS             complement(5715..6551)
                     /gene_functions="regulatory (smcogs) SMCOG1003:sensor
                     histidine kinase (Score: 136.3; E-value: 3e-41)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg114_4"
                     /transl_table=11
                     /translation="MEKNISQEKRIEELEARLKEQEKLGSLGLLSAGIAHEIQNPLNFV
                     INFSKLSGQLLADLADRVDEAKARIPEAELEDIKDILSGLRENVDKIKEHGDRAISIIR
                     GILLYSRGKEDEFMPTQIQKLTKEYVWLAYHAMRANYKNFNIAIREDYAKDIPSIRLIP
                     QDFSRAVLNVMNNACYAVWKKWQNAPEGYSPEIMVTLEKLDKRIVLSIRDNGEGMGPEV
                     KRKLFDSFFTTKPVGQGTGLGMAIVRDIIENKHHGKVLFDSVLHEYTCFRFIIPIA"
     CDS             complement(6574..9411)
                     /locus_tag="ctg114_5"
                     /transl_table=11
                     /translation="MKKIVSLIMCLCSVYANSQEGIPFFVNYPASVYQAHNRNFDVVCD
                     SCGNVYFANFEGILHYDYSRWETIYTPGFSRVTRLFRDSEGRIWVGGYNVFGRIERDGR
                     GCITLRTLLSDLDTNFLGELEDMAEIDKRIYLKATSGGYYTVQSDSILAPVQVLPAQLQ
                     EKWRNQTSVSMNRAFSLPGGETISINSAHGLIMDDSGKKERFSVTERNGLCSNAVSGIA
                     ADGRGNLWGATDNGVFHVFIPSLFSRYTSGEGLKGEVISAVSYKGMIYTGTLQGLYVLK
                     QNTFVPVQGISQACWQLCLSPQGELYAASGDGVYVIRDYNHSEKLTDMAAYSLAFIGHT
                     NLLMGTMDGIYQYSADEERIKKISDVEKVVRLEVKKDRSVWAKTLYGEIYLREEGKSSF
                     VLQDRESEEVMTEYTDNDGCHWQTNLKGKEVQVHHSQIDTEKFNQCLYAIRNYVVRVIY
                     IEEDRAAWFGGDFGLIRMDLEKARTFTPVAPRIYLREVCLNRDSVYWGGDLPEESGGAD
                     WQINSTVPRLGNDVRSIRFSFATDAPCFTGSNEYRYRLVGYDPEWSSWDSGTVKEYANL
                     SSGTYTFCVRARDIYGTESEMKQFRFSLLPPFYLQWYCLILYTVAFGMLLFLLFKWRMR
                     SLLKEKERLEALVGQRTKQLVQQKNEIEEKSLKLEKALKELGQAQDELVRQEKMATVGK
                     LTQGLIDRILNPLNYINNFSHLTSGLLKDLYQNLESVKELLDEDTYLDSVDVINMMRDN
                     LEKIEEHGSNTTRVLKAMEEILRDRNRQLEKTELIGLCRKDMELLSSYYQKEITAMHIA
                     VRTSLPDNPLFIDGNAEQLGKTIMSLLNNGMYAIAKKYGKKAYPAEIGLALESKDGQAV
                     IRLYDNGVGIEQSILDKIFDPFFTTKTTGEAAGIGLYLSKEIILNHHGQIAVRSEKDEL
                     TEFTITLPLWEEKSV"
     CDS             complement(9408..11009)
                     /locus_tag="ctg114_6"
                     /transl_table=11
                     /translation="MIKLNENIIRWIIAVPCILLTVCLVLYRAYRHSASDRERLALSLE
                     EFRDKEKKSVLIQRVSQQMEEIAYQQKDISEKRRQEAVAQTQKANRMQQQAELARERAL
                     AAQLEAEKAYRMADEQKNLAMERQLQAEQSKRVADTLAFLALGRSLGTLSVTQYRSGNM
                     ELASLLAYTAWWFTKRYDGDVYHPAVFNALSLSCRQDQLWFGHKGAVTGIKLLSGGEEK
                     AKAGRNPLPGLVTVGKYGEMIRWKSENGQTYTSELLLNDPCYDFRDVLLRSDSQMYALS
                     YCGQLISTDSAGIVTRFLPKGEYRQLISIASNLVLAVSTTGIYSFDCVNHEIQPCFQPE
                     HSITCVGQMEGYLYVFFKNGTVALLSSDGTFLRFIDSLPENSVVTAFCPLTNERYAIGC
                     REGVILICDKNGNIRQKLIGHQAAVTAISRKGNKLFSSSYDCTLRLWDLRKGKTESAVI
                     VTSPGWIHTFCFHPDGTSVFIGDEQGRLYRVPISPDHMAAVVRQGLQRDFTREEWEYYI
                     GKQIPFESYYLKTYQP"
     CDS             complement(11006..11434)
                     /locus_tag="ctg114_7"
                     /transl_table=11
                     /translation="MTLLQFRPVDGRLDEILSMLMHSREVASHPSLSYAIRLVSEEIIV
                     NILNYAYPQQAEGYLTLCLWDEDGEITLEFIDGGIPFNPLDKADPDISLPLEQREIGGL
                     GIFLVREMMDDVAYTYVNKENRLTIKKKYLQPTDEPVS"
     CDS             complement(11449..11754)
                     /locus_tag="ctg114_8"
                     /transl_table=11
                     /translation="MEKYEIHFVGSVLDSNTSGDEQAKIVALIEQGHSVALDLSGCSYV
                     SSAGLRVMLYAFKLAKAKSRDVCLVGVSQEVKDVMHMTGFDKFFRFYQTLDELSQP"
     CDS             complement(11773..12942)
                     /gene_functions="other (smcogs) SMCOG1054:hypothetical
                     protein (Score: 217.2; E-value: 8.5e-66)"
                     /gene_kind="other"
                     /locus_tag="ctg114_9"
                     /transl_table=11
                     /translation="MAVKILSVDDELDLEVLLTQYFRRQIRKGEYEFAFAHNGLEALQK
                     LLETPDFDIILSDINMPEMDGLTLLAKVNELKNPAMKCIMVSAYGDMDNIRSAMNKGAF
                     DFATKPIDLDDLSRTIEKAIEQVRYIRESQQEHNQLESIKNDLAIAGEIQQTILPRSFP
                     PFPELTEVVDIYASMTPAKDVGGDFYDFFQIDDERIGLVIADVSGKGVPASLFMAVSRT
                     LLRATALRGVSSAECLTYANKLLCKESLDSMFVTVFYGIYHYKAGMMDYTNAGHNPPYL
                     LRGGRTVECLPVASNFVVGVFDDIEFESNTLTFGIGDTLLLYTDGVTEAFNDKREQFSE
                     SNLQDILASMHESSSAKEVVTSVLQSVKTFSGDYPQSDDITLLSLQRIK"
     CDS             13290..13913
                     /locus_tag="ctg114_10"
                     /transl_table=11
                     /translation="MLIILKQDDSCQVAQTTCTTNSLEIRYKDYSVLKKTLDLNTKSIN
                     SNSCIELIIYGTHGNEKEICKLTKPDIKDLSYFFKGKVCRLVLDACHSACHIPHFKEML
                     TDDGIILCHVGICQVNSIETKTGKDTYERWINGNKEGLKVWSDGIVPAIYTQKNNTLTY
                     YECSKFEVDINHPFTETEFKTYCLNLKSKGIKMVIKNHSDFDKI"
ORIGIN
        1 attaatatat gtcaattcat ttctctctca ggtttatgca gaatagagtt tatacggttc
       61 tcttcataaa taattaattg atgcgtagcc tctgcaagat ctgacttcag gtgatacaaa
      121 taggtacgcc cggttaatct ttcttccatt atccgttcta gttctttccg tatatcatca
      181 gatggatcga tttccataac acgcggtatg atggctcccg aagctgtaga ctccccttcc
      241 tgaccttgca aataatcata ttgggacaaa gtatagtcca tcagctgatc atagtttagt
      301 tttttcctgg aagatatcgt ttctgccaaa ggaatatagt aaagaatatc cttgataaaa
      361 gagctatatt cagtctgtac gcggcgtacc agattcatat actttttttc ttcggatgat
      421 aaatgcgtag aagtgaaaga aaaggatgcg gcaaccatct gatattcgag ccctttattg
      481 atttctgtca acacctcttt ggcatatgca tagtttttca tggatataga cgaaacaacc
      541 gtattcaaca catacaaatc aatagatttg agattctctg ccagttcttg tttgaaaccg
      601 gtaaaccaat cttgttgctg agtataaatt atggtatcta actgcaggag tttcaaatcg
      661 tgatgaagta cacctgtctg ctgaagtgtc ttgttcagaa tcataatcga gatgacccct
      721 ccgatgattc ctccaatata actgccgccg aaaccaatcc aggtgggcac atcgtctgca
      781 cccgccatca gagtcaacgg attcagttcg attaatgccc aattgattgg aaaaggcagt
      841 acaagagtca agccaagcaa aataagaagc tctttcttac ctaaagtaaa gttttcagtc
      901 tgcataaatc tacttcaaaa acacagttat taattgttcc aatgattccc cttctaaaaa
      961 gtgccaatga tctgccggca atcgcaaaac aggagcgttc ggataatatt tattccataa
     1021 tctttcgcaa ttgtcatatt ctgtccggaa tatacgatag ttttcctccg tccacgactc
     1081 ttcaggagac aatcccgcct gttgatggaa caatccggac agcaaaacaa taacctctcc
     1141 ctgataaatc agattaggag tggttcgaaa ataaatattt atgatttcgt tccgttcacg
     1201 taccatttca tcggtatctc cgggaaatac caacaaagga taattttgac agagagccgg
     1261 attttgccaa gcctgtccat ccagagcaaa aacttttggc attatcccca tggagcgatg
     1321 taacatttcg gccaggccga tagccagttc agctcccata cagaagccgg taagcgcata
     1381 gacggtacgc tcccggatca ttggctgaac cgtccggaca taatattcca acagttccgg
     1441 aatatccgtg gccactttat taaaatgatc gtagatagca tctacaacta gaaagtcata
     1501 tttgggataa aggcggtcgg ccaaattaaa gtacaaatga ttaaaatagg cagatccaca
     1561 aaccagaatg attacgggtt tcttcaagtt ttgctgcctg taccaataga taggttcttg
     1621 ccgcggaacg agcaataatc ggcgcagatt acgggcagta taaactgcag atacgttgat
     1681 gggacatcct tttttattgg cctcggtaac aagcctcaac atatccagcg aagttaatcc
     1741 cagatcatca atcaaatcgg cctcaacact gacttgaggc aaacctaaca tttccttcaa
     1801 aattccacat aagataacct cccccggatg aacaggagga acatacttca actccaacga
     1861 agtaaaagcc gggagcgccc ggacatcaat tttatcattt atagtacgct gaaaatgatc
     1921 taccacctgc cataaattgg gtatcatgta gtaaggaagt tctgcacgca aacgctcttt
     1981 gacctcttcc ggatgaaagt taccggagac tgagggttgc aaataagctc ccaataattg
     2041 acgcccattc cgctcaacaa ctactacgtg ggctctctcc acgtccggat ctctattcaa
     2101 tcgttctgct atttcagtca attcgatgcg aaagccacgt attttgacct gagtatcttt
     2161 tcgcccgata aaccgtattg aaccgtccgg ttgctgctgt accaagtcac ctgtcctgta
     2221 caaccgttct ccatcgtacg agatgaatga tttttcattc agctgaacac tcccaatata
     2281 tcccagcgaa acctgaggtc ctcccaagca aagttctcct gtagcctcaa gagttgtctg
     2341 ttggaggttt tcagacaaaa cataacagac agttcccttg agcggatagc caatatcgtc
     2401 atacgacgta tctttgccta caatccgtat ggtactgagt acggtattct ctgtcggtcc
     2461 atatacattc atcaaccggt aaggctgctg tttcagcctg ttaaataact tttcaccaat
     2521 agcctccgca ccaaagagca gagtcttaaa ggatggaaag tcaaggtcgg caaacatgcc
     2581 cagcaacgaa ggagggaaaa aagcaatatt caccttctcg cgcctgatca gttcgtctag
     2641 taaagaaata tctctgcgtt cgtcctcacc ggccaggatc aatgttcctc cgaccggaat
     2701 acacatcatc agttctaata tggaagcatc aaaactgata ctcgcaaacg ccagatacct
     2761 gtttgccgga tcagacaaat gatacaattt cttatctacc agattcctcg taaatgtatc
     2821 cagattccga taactaatac gtacaccttt gggattgcct gttgttccgg aagtatatat
     2881 aatataggcg caatcatcgg gaagaacttc agtatagtca ccaacaaccg gttcggatag
     2941 ttgctcccca ttcaggtaaa gtcggcggac ggacggaatt ccacctactt cattcgatga
     3001 atcggtcaac aacaaaacca tatccgcatt ttcagccata taccgtttac gattatccgg
     3061 cagcgaggga tctatcggta aataagttgc ccctaaccgg aaaatagcca gaatggcagg
     3121 tactaaagtt ttgtttcgtt ccatacaaac tccgatacag atattccgaa gtccggacgg
     3181 atcagttacc gataaacgtt gacggataga ttgtgctata ttggcagagt aacgttccag
     3241 catttgataa gagacggtac cgtcttttgc aacgaccgcc ggtttgtcac cccaggtaga
     3301 gagtgatcga gaaagatttt cttgaatgtt tgttttcatt attagtttga tttagaaatt
     3361 atacaatata ctggcggaaa tccaccttcc tttctggcgg ataggaacag tcgctcctcc
     3421 gcattcatat cggttattga aaagattctc aatgcccaga ctgccttcta tccttttata
     3481 cttatatctg gtagtgaaag aaaagacagc ataaccgggc aaacggactg tgtaattcgt
     3541 cgcatctcca ttgagtccat cttccaatac acttacctga gtgtagcagt ggctactgca
     3601 attcaatttt aaatgggcag accagctctg tactttcttt ttaagtaaaa agtagtttgc
     3661 tacaagattc atagaaaagc cgggtacgtt attcacagat ccatcggtaa caaaaaaatt
     3721 ggtataattc aatactttct gaaaacacag gtttccatcc aggctcagtc ggtctgcctt
     3781 ataacgggca acaacctcga cacctcccat atccagagaa ccggcatttt cataaacacg
     3841 tgtttccggc tgtgtgaaca ggaaatggga cgcccgatta taaaataaat tacactctac
     3901 atctatatgt gaaggtgaat gatgataagc acaagtcacc tgatatgaac ttagatattc
     3961 agcttgcaga ttttcgccac ccgaataggt atccatttca ttgtttctgt aataataggg
     4021 cgcatcgaca aatgctctgg aataactggc tttgatattt aatccgttcc tgagataaat
     4081 tagtgacaga cggggagaaa aagcctgtaa tgtccgctta ttacttcgcc gtttatagtc
     4141 atacctgatg ccggcattga caatccaatt tttatgcagg ttgtgtttaa tctgaagaaa
     4201 ggcatccgtg ttcatctcgt gtcccgtgta aagtcgtttt tcgatccacg tcctgacgat
     4261 ctctttaaaa ttcatacctt ccaaatactc ggaatcataa agcgtatacc gattccattc
     4321 cacaccgcca agcatattgc ctttccccag cttcccccaa tcataggcat agtttacacg
     4381 cccattaaag cctacgttaa aatccatcca gcggatgtat tgaaatgctc cgcgagtcgg
     4441 ataaataata ggttgataat catagttagg aaaaatagga tagtcttgta aagtatctcc
     4501 cgaggtttca taatgtacgt ttttattcca atcggtataa aatgcggtac tgaaagtgat
     4561 ccgctgccac gtgcggctat aaacagcctg ttctcttgcc gaccacctgg aatatcccgg
     4621 gccggaaccg tcaaaagtac gaaaccgctc ataagaatat ggagaagaaa agagccacat
     4681 gctataaggt tgccttttct tcgcgtaatt catactgaaa ctaaaaagca aatttccacg
     4741 ttgcaattta attcctccat ccatggcagg aaatcccgaa taattgtcca gacggatgaa
     4801 tccgtccctg gggtaaagag catattgttt ttcggccggg acaaaaaccg attctcccgt
     4861 tgcacggtac aaggagaacc atgccataaa gtccatgttc atgtcgtgct ttcccaatag
     4921 caggtcagca gccaactggc cccgattacc ggcgctgaca gatatggaac cattacgaac
     4981 atccaccccg tctttagtaa ctatattaat cacggctgtc aaagccacac tgccataaag
     5041 cgaagaagcc ggtccgcgca gcacctctat ttgtttgact tttgccagac taataccata
     5101 atccggcgaa acagcattag taatataact gttcagacgt tgtccatcct gcataatcaa
     5161 tatgttctcc tgttcgggag aatatacccc gcgcatagcc agattcatct cttcattgga
     5221 agacaaaccg gatataccgg gcacataagc tatcagtaca tcccgcaggc accgggcatg
     5281 gatagcccgt atcatctcct ccgtaattaa agtaacaggc accggagctt cttccggggt
     5341 ctctacctgt tgtgaggctg tgaccagagt tactttagtc tccctgtgtt tccttaccat
     5401 atccgcaaag cgttccggat cttgaagcga gatataataa taaggttcgt ctttcaataa
     5461 cagcgaaaca tacttttccg cttccgggaa gcggtctaaa gctaaacagc ataatgcagc
     5521 caaacggcac gcctcggtat gcatcgtacc ttgaaaagac gacagattct cctccaagat
     5581 acgacaagct tcatcgatat ctccgctctt ataaaatgtt tccgccttta caaacgaatt
     5641 acggatgtta tccgccggct gagctgacag ttgcacaacc ccaaagcagc aaaggatata
     5701 tagcagacag cgtttcatgc gataggaatg ataaaccgga aacaagtata ttcatgcagg
     5761 accgaatcaa acaatacttt tccatggtgt ttgttttcta taatatcacg aacgattgcc
     5821 ataccaaggc ctgtcccctg ccccaccggt tttgttgtga aaaaagagtc aaatagtttt
     5881 cgtttgacct ccggacccat gccctctccg ttatcacgaa tagaaagtac aattctttta
     5941 tccaactttt ctaaggtcac cattatctcg ggggaatatc cttcgggagc attctgccat
     6001 tttttccata ctgcatagca ggcattattc atcacattca agactgcccg actgaaatcc
     6061 tgcgggatca gccggatcga ggggatatct ttagcataat cttcacggat agcaatattg
     6121 aaattcttat aattggcccg catggcatga taagccagcc acacatattc tttagtcaat
     6181 ttttgtattt gtgtaggcat gaattcgtct tctttccccc tggagtaaag caaaatacca
     6241 cgaataatgc tgatagcccg atcaccatgc tctttgattt tgtccacatt ctctctcagc
     6301 ccggaaagta tatctttgat atcttccagt tccgcttccg gaatacgagc ttttgcttca
     6361 tccaccctat cggccaggtc ggccaacaat tgaccggaca gtttactgaa attgatgaca
     6421 aaattcaaag gattctgtat ctcgtgtgca atgcctgcac tcaacaaacc caatgatccc
     6481 agcttttcct gctctttgag ccgtgcttcc aactcttcaa ttcgtttctc ttgtgaaatg
     6541 tttttttcca taatcaatct gttctatgtt tatttatact gacttttcct cccacaatgg
     6601 cagagtgata gtgaattctg tcaattcatc tttttcagaa cgtactgcta tctgcccatg
     6661 gtgatttaat atgatttcct tactcagata caaaccgata cctgctgcct ctccggttgt
     6721 tttggtagta aagaacggat cgaagatttt atccagaata ctctgctcga tccccactcc
     6781 attgtcatat aggcgaatga ctgcctgtcc gtccttactt tccaatgcca ggccaatctc
     6841 tgccggatag gctttcttac cgtatttttt ggctatggca tacataccat tgttaagaag
     6901 actcataatg gtttttccca gttgttcggc attcccgtca ataaacaacg gattatcggg
     6961 caaggaagta cgaaccgcaa tgtgcatagc cgtaatctcc ttctgataat aactgctcaa
     7021 tagctccatg tctttccggc ataaaccgat taattctgtt ttttccagtt gcctgttacg
     7081 gtctctcagg atttcttcca tggccttcag tacacgagtg gtgttacttc catgttcctc
     7141 aatcttttcc agattatctc tcatcatgtt gatgacatct accgaatcca agtaggtatc
     7201 ttcatccaaa agttctttta cactctccag attctgatat aggtccttca gtaatcctga
     7261 ggtcaggtgg gaaaaattat taatgtaatt caacggattc agaatacggt caatcaaccc
     7321 ttgagtcagt ttacctacag tagccatttt ttcttgtcga accaattcat cttgtgcctg
     7381 gcccagctcc ttcaatgctt tttccaattt taaggacttt tcctcaattt catttttttg
     7441 ttgtaccaac tgtttggtac gttggccgac aagggcctct aacctctcct tctctttcag
     7501 caaactgcgc attctccatt taaacaataa gaacaacagc attccaaaag caacggtata
     7561 taggatcaga caataccatt gcaaataaaa aggaggcaat aacgaaaagc ggaattgttt
     7621 catttcactc tctgtaccgt aaatatcacg ggcccggaca caaaacgtat acgtacccga
     7681 cgaaaggttg gcatactctt tcacagtccc ggaatcccac gaactccatt ccggatcata
     7741 accgaccagg cgatatctat actcattgga accggtgaaa cagggcgcat cggtagcaaa
     7801 tgaaaaacga atggaacgta catcattccc caaacgaggt actgtactat ttatctgcca
     7861 gtccgctccc ccggactctt ccggcaaatc tcctccccaa tagacagaat cacggttcag
     7921 acaaacttca cgaagataga tgcggggagc aaccggagta aatgtccggg ccttttcaag
     7981 gtccatccga attaaaccaa aatcaccgcc gaaccatgcc gccctgtctt cttcaatata
     8041 aatcaccctc acgacataat tccgaatggc atacaggcat tggttgaatt tctccgtatc
     8101 aatttgcgaa tgatgtacct gtacctcttt tcctttcaga tttgtctgcc aatgacagcc
     8161 atcgttgtcc gtatactcgg tcattacttc ttcactctct ctgtcttgaa gtacaaaaga
     8221 gcttttgccc tcttcccgca aatagatttc tccgtacaac gttttagccc atacagaacg
     8281 atctttcttc acttccagac gaacgacttt ttcgacatcg gaaattttct ttatccgttc
     8341 ctcatctgcc gaatattgat aaatcccatc catagtgccc atcagaaggt tcgtatgccc
     8401 aatgaatgcc aatgaataag ctgccatatc tgtgagtttt tccgaatgat tataatcccg
     8461 gatcacatac acaccatcgc cggacgctgc atataattct ccttgtggag aaagacacag
     8521 ttgccaacat gcttgcgaaa ttccctgaac aggaacaaaa gtgttttgct tcaatacgta
     8581 taatccctgt aaggtcccgg tatatatcat tcctttgtaa gagacagccg atattacctc
     8641 tcccttcaga ccttcaccag aggtataacg gctgaacaaa gagggaataa aaacatgaaa
     8701 cacaccgtta tccgtagctc cccagagatt gccacgccca tcggccgcaa tacccgaaac
     8761 agcgttactg cataagccat ttctctcagt tacggaaaac cgttcttttt tcccactgtc
     8821 atccattatt aatccatggg cagagtttat cgagattgtt tctcctccgg gtagagaaaa
     8881 cgcccgattc attgagactg aggtttgatt tctccacttt tcctgcaatt gggccggaag
     8941 tacctgaacc ggtgccaaaa tggaatctga ctgaaccgta taatatcctc ctgatgtagc
     9001 tttcagataa atgcgtttat ctatttctgc catatcttcc aattcgccca aaaagtttgt
     9061 gtccagatcg gaaagaaggg ttctcaacgt aatacatccg cgtccatcac gctctatccg
     9121 tccgaacacg ttatatcctc ccacccatat cctaccttcc gaatcacgaa acaaacgggt
     9181 gacacgggaa aagcccggtg tataaatagt ttcccaacgg ctatagtcat aatgaaggat
     9241 accttcgaaa ttagcaaaat agacatttcc acaactgtcg caaacgacat cgaaattacg
     9301 attgtgcgcc tgataaaccg aagccggata gtttacaaaa aacgggatac cttcttgtga
     9361 atttgcatat accgagcaaa gacacattat caaagagact atctttttca tggctgatac
     9421 gtttttaggt aataggattc aaatggaatt tgcttaccga tataatactc ccattcttct
     9481 cgagtaaaat cacgctgtaa cccctgacgg acaacagcag ccatgtgatc gggtgaaata
     9541 ggtacccgat acaaccgccc ctgttcgtct cctataaaga cagatgtacc gtccggatga
     9601 aagcaaaaag tatgaatcca accggggctt gtcacaataa cagccgactc ggtctttcct
     9661 ttacgaagat cccacagacg cagtgtacaa tcgtaactac tcgaaaacag tttgttccct
     9721 ttccgggaaa tagcagtaac cgcagcctga tgccctatca acttctgccg gatatttcca
     9781 ttcttatcac aaatcaggat aactccttca cgacagccaa tggcatatct ttcattggta
     9841 agaggacaga atgcagtaac cacactattc tcgggcaagc tgtctataaa tctgagaaat
     9901 gtaccatccg acgaaagtaa agctactgtc ccattcttaa aaaaaacata gagatagcct
     9961 tccatttgac cgacacaagt tatcgaatgt tccggttgaa aacaaggttg tatctcatgg
    10021 ttgacacagt caaaagaata aataccggtt gtggaaaccg ccaataccaa gttagaggca
    10081 atcgaaatca attgccgata ttctccttta ggcaaaaagc gggtaacgat accggcggaa
    10141 tccgtggaga taagctgccc gcagtatgac aaggcataca tctgtgaatc ggaccgcaac
    10201 agcacatccc gaaaatcata acagggatca ttcaacagta attcggaggt ataggtctgc
    10261 ccattttccg atttccaacg tatcatctca ccgtacttgc cgacagtgac caatcccggc
    10321 agaggattcc gaccggcttt tgctttttcc tcgcctccgg ataacagttt gatcccggta
    10381 acagctcctt tatgcccgaa ccaaagctga tcttgcctgc aagacaaaga caatgcattg
    10441 aaaacagccg gatgatatac atcgccatca tatcgcttgg taaaccacca ggcggtatat
    10501 gccaacagag aagctaattc catgttgccc gaccgatatt gagtaacaga gagtgtcccc
    10561 aatgaacgtc ccaaagccag aaaagccaat gtatcggcaa ccctcttcga ctgttcggcc
    10621 tgtagttgcc gttccatcgc cagattcttt tgttcatctg ccatccgata cgctttctca
    10681 gcctccaatt gtgcagcaag cgctctttcc cgtgccaact ctgcctgctg ttgcattcgg
    10741 ttggcctttt gagtttgcgc aacagcttcc tgtcttctct tttcggaaat atccttttgt
    10801 tgataagcaa tctcctccat ttgttgactg acccgttgta taagaaccga tttcttttct
    10861 ttatcccgga attcctccag agacagagca aggcgctccc tgtccgatgc cgaatgacga
    10921 tatgcccggt ataggaccag acatactgtc aaaagtatac aaggaacggc aatgatccaa
    10981 cggatgatat tttcgtttaa cttgatcatg atacaggttc atcagtgggt tgcagatatt
    11041 tctttttaat ggtcaaccga ttctccttat tcacgtacgt atacgctacg tcatccatca
    11101 tttcacgtac caggaaaatg cccaatcctc ctatttcacg ctgttctaac ggtaatgaaa
    11161 tatcaggatc ggctttatcc aaaggattga atggaatacc accatctata aactccaaag
    11221 taatctctcc gtcttcatcc cataagcaca gagtcagata accttctgcc tgctgcggat
    11281 aagcgtaatt gagaatattg acaatgatct cctcactgac caaacggata gcataagaca
    11341 gggaaggatg tgaagcaact tcacgactat gcatcagcat actaagaatt tcatctaacc
    11401 tcccatcgac agggcgaaac tgaagtaacg tcattgctca ggtaattttt agggttgtga
    11461 taattcatcg agagtctgat aaaaacgaaa gaatttatcg aatccggtca tgtgcatcac
    11521 gtctttaacc tcttgtgaca caccgacaag gcaaacatct ctacttttag ctttcgccag
    11581 cttaaaggca taaagcatga ctctcaatcc ggcactggat acataagaac agccgctgag
    11641 atctaatgca acagaatgtc cttgctcgat aagagctaca atttttgctt gttcgtcacc
    11701 gcttgtattt gaatccaaga cggaacctac aaaatgaatt tcatactttt ccatcgttct
    11761 tttattttaa tattatttga ttcgttgaag agaaagcagg gttatgtcat cggactgagg
    11821 atagtctccg gagaaagtct taacagactg caatacactc gtaacaacct cttttgcgga
    11881 actactttcg tgcatagacg ccaatatatc ctgtaagtta ctttccgaga attgttcccg
    11941 cttgtcgtta aaagcctctg tgacaccatc cgtatacaga agtaaagtgt caccgatgcc
    12001 gaacgtcaat gtattactct caaattcaat atcatcgaac acgcctacca caaaattaga
    12061 agcgacaggc aagcattcaa cagtccgtcc gccgcgaagg agataagggg gattatgccc
    12121 ggcattggta tagtccatca tgccggcttt ataatgataa atcccataaa agaccgtaac
    12181 aaacatagag tccaggctct ctttacacag taacttattg gcataagtaa ggcattctgc
    12241 cgacgaaaca ccccgaagag cagttgcacg gagcagggtc cgactaaccg ccatgaacaa
    12301 ggatgccggc acacctttcc cggatacgtc agcaatcacc agcccgatac gttcatcgtc
    12361 aatctggaag aaatcataaa aatcgccacc tacatctttt gccggagtca tggaagcata
    12421 aatatcaacc acttccgtca gttccggaaa aggaggaaag gaacggggaa gaatcgtttg
    12481 ctggatttct cccgcaatgg ccaggtcatt tttgatagat tccagttggt tgtgctcctg
    12541 ctgtgactca cggatatagc gaacctgttc gatcgccttt tcaatagtcc gcgacagatc
    12601 atccaaatcg atcggtttgg ttgcaaaatc aaacgctccc ttgttcatag cagaacgtat
    12661 gttatccatg tctccataag cagagaccat tatacacttc attgccggat ttttcagttc
    12721 attgacctta gccaataggg tcaacccatc catctccggc atattaatat cactcaggat
    12781 gatatcgaaa tcgggagttt ccagaagttt ctgtaaagct tccaacccgt tatgggcaaa
    12841 agcgaactcg tattcacctt ttcgtatttg tcgcctgaag tactgggtaa gtaatacttc
    12901 taaatcgagt tcatcatcta cactcaatat ttttactgcc atatctattg ttatttatga
    12961 atttcaaccg tttgttctga cgtttatgat ggcaaaaata gagcgtgacc gccccggtta
    13021 caattttata ttttaaacag gaaaaatgtt tttccgaatg gacgatattg tcttataagc
    13081 atacaggtat attgctttcg tgccttagaa gacagcacct gaaagattga tttacactcc
    13141 tgaaagaaac tattccgtat tcagaaatta tatttttaag atggaacttt tcttctcact
    13201 tttgtcaccg taagcttaca aagaataaat agaaacggcg gattccgaaa agccgaagaa
    13261 agagtaggaa ctttttacga attactatta tgcttattat tttaaaacaa gatgatagtt
    13321 gtcaagttgc acaaacgaca tgtacaacaa actctttaga aatccgatac aaagattata
    13381 gtgtactgaa aaaaactctg gatttgaaca caaaatctat taatagcaat agctgtatag
    13441 agttaattat ttacggaaca cacggaaatg aaaaggaaat ttgcaaacta accaaaccag
    13501 acataaaaga tctgagctat ttcttcaaag gaaaagtttg tagattagtt cttgatgctt
    13561 gccatagcgc ctgccatatt ccacatttca aagagatgtt aacagatgat ggaatcatat
    13621 tatgtcatgt aggtatctgc caagtaaaca gcatcgaaac taaaacaggt aaagacacct
    13681 atgaacggtg gataaatggc aataaggaag gattaaaagt atggtcggat ggaatcgttc
    13741 cagctatcta tactcaaaag aataacactt taacttacta cgaatgtagc aaattcgaag
    13801 tagatattaa tcaccctttt accgaaactg aatttaagac ttattgtctg aatttaaaat
    13861 caaaaggaat taaaatggta attaaaaatc attctgattt cgataaaatc taactatctt
    13921 atataaatca tataac
//
