LOCUS       c00052_gnlPro..        11597 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|JEJEJGKB_52.
ACCESSION   c00052_gnlPro..
VERSION     c00052_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 01:52:21
            Original ID  :: gnl|Prokka|JEJEJGKB_52
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 11597
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..1434
                     /locus_tag="ctg52_1"
                     /transl_table=11
                     /translation="HLRDVLLGQEKPGQRELFPIRFPWLNRSQEEAVNKVLGAKQVSIV
                     HGPPGTGKTTTLVEAIYETLHRENQVIVCAQSNTAVDCISEKLVDRGINVLRIGNPTRI
                     NDKMLSFTYERRFESHPDYPELWSIRKAIRDIQSNMRKKSREERDTIRNRLSRLKFRAT
                     ELEVKIDTELFDEARVVACTLVGSANRVMMNRHFTTLFIDEAAQALEAACWIAIGKADR
                     VILAGDHHQLPPTIKCIEAEREGLGRTLMQKIAHTKPETVSLLKIQYRMHEDIMRFSSQ
                     WFYHNELESAPEVSGRGILRLDTPIVWFDTSECDFTENTREETMSRVNRQEAELLVEQL
                     RSYIQKISKERVLEENIDFGLISPYKAQVQYIRKLIKQDAFFKPLRRLITVHTVDGFQG
                     QERDVILISLVRANEDGKIGFLNDLRRMNVAITRARMKLMILGDASTLTRHAFYKELYN
                     YISQRGKIITINTKQEHEL"
     protocluster    1..11597
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2488:7346]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      2489..7346
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
     cand_cluster    1..11597
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /kind="single"
                     /product="TPP_fatty_acids"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..11597
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_fatty_acids"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /tool="gutsmash"
     CDS             1424..2230
                     /locus_tag="ctg52_2"
                     /transl_table=11
                     /translation="MNYKLLVLDLDGTLTNSKKEITPFTRETLLQAQEKGLHLVLASGR
                     PTYGIVPLAEELNIKQYGGFILSFNGGKVIDLMTDKVLFEQALPPDIVPVLYNRSKEAG
                     LAILSYNGKYILSEHPENKYVQYESFLTKMKIKATDDFLRDLHQPADKCLVVGEPEMLV
                     PLEEKLRQELGKRINVYRSEAFYLELVPKGIDKAASLSRLLERTRIKQEEVIAIGDGFN
                     DVSMIRFAGLGVAMANAQPPVKANADRITQYTNDEDGVARFIQELL"
     CDS             2489..3721
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: HBT"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg52_3"
                     /sec_met_domain="HBT (E-value: 1.4e-17, bitscore: 53.4,
                     seeds: 132, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKYKLLVLDVDGTLLNDKKEITPRTHAALLKAQQMGVHVVLASGR
                     PTNGVQPLAEALELNHYGGFILSYNGGQIINAQTGELMFEKRIDPAMIPYLNRKAKENG
                     FAIFTYHKDYILTDSPENKHVQEEAELNKMRIIGVENFPEAVDFAPCKCILTSDDENNL
                     VGLENHWKKRLDGVLEAFRSEDYFLEVAPHFINKGNTLAVLMEMLNITTEEVVAIGDGV
                     ADVSMLQLAGTGVAMGNARDSVKACADFTTLSNNMDGVAVAIEKAILATIKPTEVPLDQ
                     LNARAKHALMGNLGIQYTYASEDRVEATMPVDERTRQPFGILHGGATLALAETVAGLGS
                     MILAKPDEMVVGMQVSGSHMSSAHEGDTVRAVGTIIHKGRSSHVWNVDIFTSTDKLVSS
                     VRVINSILKKK"
     CDS             3718..4815
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Chorismate_bind"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg52_4"
                     /sec_met_domain="Chorismate_bind (E-value: 1.2e-54,
                     bitscore: 175.0, seeds: 119, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIPRDSYEIIDTLIKQGRSFAIWRIPGEDRLHFRMQSAGSPCLLY
                     DIKDLNERSGFVIAPFQVTAERPIVLIQPDCFEIPSESDWDFSREKNEFPSNEIEIPSE
                     SEEKERYAYHFSLFTSPLLKGSQDKLVLSRSKTIRKDPSFSPGKAFFAAVERYIRSYVY
                     LCHTPETGTWMGGTPEILLSGEKGDWQTVALAGTQSLRDGKLPKSWDHKNWREQQLVAS
                     YIRRQLSTLGITPEEKGPYSARAGEVSHLKSDFFFSLPNPEKLGDVLQLLHPTPAVCGL
                     PKEEAYHFIIENEGYDRSYYSGFIGWLDPKGKTDLYVNLRCMNILPQTFTLYAGGGLLA
                     ASQLEDEWQETEDKLDTMRRIVGNL"
     CDS             4830..6518
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg52_5"
                     /sec_met_domain="TPP_enzyme_C (E-value: 7.2e-08, bitscore:
                     21.8, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYSDKKNILQLVALLIEHGVSNIVLCPGSRNSPIVHTLANHSFFN
                     CHSVTDERSAGFFAVGLALHGGKPAAVCCTSGTALLNIHPAVAEAFYQKVPLVVISADR
                     PAAWIGQMDGQTLPQPGVFGSLVKKSVQLPEIHTDQDEWYCNRLINEALLELNHHGKGP
                     VHINVPISEPLFQFTTPELPKVRVITRYQGLNVYDRKYDDLIERLNKYSKRMMIAGQMS
                     LIYLFEKKICKLLYKHFTWLSEHIGNRIVPGLPIKNFDAILYATPEEEKEKLVPELVIT
                     YGGHIVSKRLKEFLRKHPPKEHWHVSLDGEVADLFGSLTTVIEMDAFEFLEKIAYMLEN
                     RQIEYPKAWEYKSRNLPEPEFAYSEMAAIGGLIRSLPAESALHLGNSSTVRYAQLYTVP
                     ETVEVCCNRGTSGIEGSLSTAIGYASASQKLNFIVIGDLSFFYDMNALWNGNLHNNLRI
                     LLLNNGGGEIFQALPGFKMNERTHRYVTASHQTSAEGWATERGFSYSAVHNAEELAAAM
                     SAFTQTEQPSEHPLFMEVFTDKAEDVRLLKEYYHQLKNSSQAQNI"
     CDS             6522..7346
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: ECH_1"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg52_6"
                     /sec_met_domain="ECH_1 (E-value: 2.4e-82, bitscore: 265.4,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="METKREWTTIKEYEEILFDFYNGIARITINRERYRNAFTPTTTTE
                     MSDAFYICRERPDINVVVLTGAGDTAFCAGGDMNVKGRGGYVGKDGVPRLNVLDVQKQI
                     RSLPKPVIAAVNGFAIGGGHVLHVVCDLTIASENAIFGQTGPRVGSFDAGFGSSYLARV
                     IGQKKAREIWFLCRKYNAQEALDMGLVNKVVPLDKLEDEYVQWAEEMMLLSPLALRMIK
                     AGLNAELDGQAGIQELAGDATMLYYMTDEAQEGGKAFLEKRRPRFEDYPKFP"
     CDS             7384..8442
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MR_MLE_C"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg52_7"
                     /sec_met_domain="MR_MLE_C (E-value: 1.4e-30, bitscore:
                     95.9, seeds: 401, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVKERFYKTEVVPRCLTFKRPAGTSRGVYTTRKLWEVRIRKEDEP
                     SVIGIGECAPLPDLSCDYGVDYEITLSKACLDLEQKGYVDTESLRHYPSILFGLEMAMR
                     HYEQGGWRHYDTPFSRGQAGIPINGLIWMGDYKYMLEQVEEKMKEGFRCVKLKIGAIDF
                     DRELSLLKHIRTHFSAKEIELRVDANGAFTPPEAMDKLKRLAEMDLHSIEQPIRAGQLE
                     EMAHLAAESPLPIALDEELIGCNAPDEKRRLLETIHPQYIILKPSLHGGISGCTEWIHL
                     AEAILGSTPEQPKWWVTSALESQIGLNAIAQWCATLGNPLPQGLGTGEIFKDDKHRLIQ
                     RKGDTIWFTNDL"
     CDS             8446..9513
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1025:AMP-binding enzyme (Score: 52.4; E-value:
                     1.1e-16)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg52_8"
                     /sec_met_domain="AMP-binding (E-value: 1.8e-17, bitscore:
                     52.4, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPIQEDLQAFLAEWHDPSPFLEVQTSGSTGTPKRMRVRKDRMLNS
                     ARLTCDYLGLKKGDKALLCMPLRYIAGKMMVVRSLYAGLDLEVREPSGHPLADWGDTPL
                     RFAAMIPLQVYNTLRVPEERKRLEQTDILIIGGGAIDAALEQEIRQMPNTVYSTYGMTE
                     TLSHVALRRLNGPEASPYYHPFPSVTLSLSPDNTLVIDAPLVCDERLVTNDVARLLPDG
                     SFAIIGRKDNIINSGGIKIQIEEVEERLRPYLDLPYAITAAPDPRLGEAVVLLIAPRSC
                     ETVSPPRVTPHMKAIMSDSAQLSCEVSTVALASLPKYLRPRHVIEASEIPQTGSGKIDR
                     AACRELARNIITKTL"
     CDS             9516..11474
                     /locus_tag="ctg52_9"
                     /transl_table=11
                     /translation="MKRILTITAVSLLALSPMYGQDSCRYPQDPTLEKSQAYAGYDCVT
                     LLDSTAVTVQPTGSGAFAVCKAFKVQTPKGAVANRIIKYDYDPLTAHAEFRYATIYRAN
                     GDVINLDVTGACDYAAPARAIYWGARQIMLEVGRLQPGDVVEYEIAKKGFTYALLTAGD
                     DERFIPPMRGQFYDIVPFWATEPTVRKVYRVSMPMEKELQFQFYQGECTSSMRYEDGRK
                     VYTFASDDILPFAKEPNMVDLFDAAPKLMMSSTPRWEDKSVWFNKVNEDYGSFTAIPEA
                     QRKVDELIKGKKTEMEKIAVLTHWVADNIRYSGISMGKGEGFTLHNLKMNYTDRCGVCK
                     DIAGTLIAFLRMAGFEAYPAMTMAGSRVESIPADHFNHCVAVVKLASGTYMPLDPTWVP
                     FCRELWSSAEQQQNYLLGVPEGSDLCLTPVSAPENHYVRIHADNRLDEKGTLRGQFTIT
                     AEGQSDSNIRRIFTTGWQSDWQNTMEKQLLAVSPNAKLLRVDYGKDPKNYQAAPIKITF
                     SYEIPDYAIIAGDQMLIKPLVMNNLYNQVKSFLRIDTKPENRAYGFKDACSRLVEQDET
                     IRLPKGYTLLNAPKNDALRSNAADFEGSLSQEGDRNIVLRQKLALKKRVYDAADWKGFR
                     SAVNAYKSYGDYLIIKK"
     CDS             11488..11595
                     /locus_tag="ctg52_10"
                     /transl_table=11
                     /translation="MIKITYKLILLLSLLAMTVTSFAASEAEYGKVSKAW"
ORIGIN
        1 catctaaggg atgtattgct gggacaggaa aaaccgggac agcgggaatt attcccgatc
       61 cgcttccctt ggttgaaccg ttctcaggaa gaagccgtaa ataaggtatt gggagcgaaa
      121 caagtatcta tcgtacacgg ccctcccgga actgggaaaa caaccacctt ggtggaagcc
      181 atttacgaga cccttcaccg ggagaatcaa gtgatcgttt gcgcccaaag taataccgcc
      241 gtagactgca tctcggagaa actggtagat agaggcatta acgtcctgcg catcgggaac
      301 cccactcgta tcaatgacaa gatgctctct ttcacatatg aacgccgttt cgagtcgcat
      361 ccggattatc ccgaattatg gagcatccgg aaagcgatac gggatataca atccaatatg
      421 cgaaagaaaa gccgggagga acgggatacg atccgaaacc gcctctcccg tttgaaattc
      481 cgggcgaccg aactggaagt caagatcgat acagagctgt tcgacgaggc tcgtgtcgtt
      541 gcttgcacct tggttggctc cgcaaaccgg gtcatgatga accggcactt cacgaccttg
      601 tttatcgacg aggccgccca agccttggaa gccgcttgct ggatagcgat cggcaaggcg
      661 gaccgggtca tactagcggg cgatcatcac caattgcccc ctactattaa atgtatagaa
      721 gcggaacgag aaggcttagg acgtaccttg atgcaaaaga tagcccacac gaaaccggaa
      781 acagtctctc tcctgaagat ccaatatcgt atgcacgagg atatcatgcg cttctcctcc
      841 caatggttct atcataacga actcgaatcc gctcccgagg taagtgggcg aggaatcttg
      901 cgactggaca ctcccatcgt atggttcgat acgtccgagt gcgatttcac ggaaaatacg
      961 agagaggaga ccatgagccg tgtcaacagg caagaggcgg aattgctcgt ggaacaatta
     1021 cgctcctata tacagaaaat atccaaggag agagtgctgg aggagaatat cgacttcgga
     1081 ttgatctccc cttataaggc gcaggtacaa tacatccgta aattaatcaa acaggacgct
     1141 ttcttcaagc ctttacgcag actgattacc gtacataccg tagacggttt ccaagggcaa
     1201 gaacgcgatg tcatcttgat cagtttggtg agggccaacg aggatggaaa gataggcttc
     1261 ttgaacgact tacggcgcat gaacgtagcg atcacccgtg cccgtatgaa actgatgatc
     1321 ttgggagacg cttccaccct tacccggcac gcattttata aagaactcta taattatatc
     1381 tcccaaagag gtaaaataat cacgatcaac acgaaacaag agcatgaact ataaattatt
     1441 ggtactggat ttagacggta cactgacaaa cagtaaaaaa gagatcaccc cgtttacgag
     1501 ggaaaccctt ctgcaagcgc aggaaaaagg attgcatctg gtcttagcct ccggccggcc
     1561 cacctacggt atcgtgcctt tagccgagga actgaacata aagcaatatg gtggttttat
     1621 cctttccttc aacggcggta aggtgatcga cttgatgaca gacaaagtac ttttcgaaca
     1681 ggctttgcca cccgatatcg tacctgtttt atacaaccgc tccaaagaag cgggactggc
     1741 tatcctttcc tacaacggta aatatatctt aagcgaacac ccggaaaata aatacgtaca
     1801 atacgaatct ttcttaacca aaatgaagat caaggctacc gacgatttcc tgcgggattt
     1861 gcatcagcca gccgataaat gcttggtggt aggcgaaccg gagatgttgg taccgttgga
     1921 agagaagctc cgccaagaat tagggaaacg tatcaacgta tatcgttccg aggcattcta
     1981 tctggagctt gtccccaaag gcatcgacaa agccgcctcg ttatcccgct tactagagcg
     2041 aacccggata aaacaggagg aagtgatcgc tatcggcgac ggtttcaacg atgtatccat
     2101 gatccgtttc gccggattgg gagtcgctat ggccaacgcc cagccccctg tcaaggccaa
     2161 tgccgaccgc atcacccaat acacgaacga tgaggatgga gtggctcgtt tcatccaaga
     2221 attgctttga aaaaaacacg tacgtatttt ccgagaaaca cgtacatgtt ttcgcgagaa
     2281 cacgtacgtg ttttttcaga gacatttaca ccagtatcgg cacaggccaa tgcctatatc
     2341 ggcataagcc tgtacgtata tcgccgcaag gctacaccga tataggcgtg agcttgcgcc
     2401 gatatacgta aattcctttc atggaaatgt cttctaacta tcaactattt tatgtacatt
     2461 tgtattctaa accataaaat aagacgccat gaagtacaaa ttattagtct tagacgtaga
     2521 tgggacgttg cttaacgaca agaaagagat aactccccgg acccatgccg ccctgttaaa
     2581 ggctcagcag atgggagttc atgttgtatt ggcatccggc cgacccacca acggggttca
     2641 acccttggcg gaggctcttg aattgaatca ttacggtggt ttcatattat cttataacgg
     2701 aggtcagatc atcaatgccc agaccggaga attgatgttc gagaaacgaa tcgatccggc
     2761 catgattcct tatttgaacc ggaaggcgaa ggaaaacggt tttgctatct tcacgtatca
     2821 caaggactat atcctgaccg atagcccgga aaacaagcat gtccaagagg aggccgaact
     2881 caataagatg cgcatcatcg gtgtggagaa tttcccggaa gcggtggatt tcgcaccctg
     2941 taagtgtatt cttaccagcg atgacgagaa caatctagtg ggtctcgaaa atcattggaa
     3001 gaaacgtctg gacggggtat tggaagcttt ccgctccgag gactatttct tggaggtagc
     3061 tcctcatttc atcaataagg gaaatacgtt ggcggtattg atggagatgc tgaatatcac
     3121 gaccgaagag gttgtcgcta ttggtgatgg cgtagccgac gtatccatgc ttcaattagc
     3181 cggtaccggc gtggcgatgg gtaacgcacg cgactccgta aaggcttgcg ccgatttcac
     3241 gaccttatct aataatatgg atggtgtggc ggtagcgatc gagaaagcga tccttgccac
     3301 gatcaaaccc acggaggttc cgttagatca actaaacgca cgggccaaac atgccttaat
     3361 gggtaatcta ggcattcaat atacctatgc gtcggaggat cgtgtggaag cgaccatgcc
     3421 tgtagacgaa cggacccgcc agcctttcgg tatcttgcac ggaggcgcta cgctggcttt
     3481 ggcggagacc gtggccggac taggttccat gattctggcg aaaccggacg agatggtagt
     3541 cggcatgcaa gttagcggca gccatatgtc gtccgcccac gagggagaca cggtacgtgc
     3601 cgtcgggacg attatccaca aaggccgttc atcccatgtg tggaacgtag acatattcac
     3661 ctctaccgac aaactggttt cctcggtacg ggtaatcaat agcatactaa agaagaaatg
     3721 attccaagag attcttacga aataatagac acgttgatca agcaaggccg gagtttcgct
     3781 atttggcgta ttcccggtga ggataggctc catttcagga tgcaaagcgc cggctctcct
     3841 tgcctattat acgacataaa agacttaaat gaacggagcg gttttgtaat cgctccgttt
     3901 caggtgacag cggaacgacc tatcgtttta atccaaccgg attgctttga aatcccctcc
     3961 gaatccgatt gggatttctc tcgagagaaa aacgaattcc cttcgaatga aatcgaaatc
     4021 ccatccgaat ccgaggagaa ggaacgatac gcttaccatt tctccctgtt taccagccct
     4081 ttgctaaaag gaagccaaga taaactagtc ctatcccgta gcaaaacgat ccggaaagat
     4141 ccctctttct cacccggcaa ggcattcttc gccgcagtag aacgatatat ccgctcctat
     4201 gtctaccttt gccatacccc ggaaaccgga acttggatgg gtgggacacc ggaaatcttg
     4261 ttatccggcg agaaaggcga ctggcaaacg gtagctttgg ccggaaccca atccttacga
     4321 gacgggaaat taccgaaaag ctgggaccat aagaattgga gagaacagca attagtcgcc
     4381 tcctatatac gccgccagct gtccaccttg ggtattactc ccgaggagaa ggggccttat
     4441 tcagcccggg ccggagaggt ttcccatttg aaaagcgatt tcttcttctc cttgccgaat
     4501 cccgagaagc tgggtgatgt ccttcaacta ttacacccta ctccagccgt ttgcggtctt
     4561 cccaaggagg aggcttatca tttcatcatc gagaatgagg ggtacgatcg tagctattac
     4621 tccggtttca tcggttggct ggatcccaaa ggcaaaacag atctgtacgt aaacctccgt
     4681 tgcatgaata tcctccccca aacctttacg ctgtatgccg gaggcggtct gttggcggcc
     4741 tcgcagctag aggatgagtg gcaggagaca gaggataaat tagatacgat gcggagaata
     4801 gtgggtaatt tataatttta tatcatataa tgtatagcga taaaaagaac atccttcaat
     4861 tggtagcctt gctgatagag cacggcgtaa gtaatatcgt gctatgtccg gggagccgga
     4921 actctccgat tgtgcacaca ttggcaaacc attcgttctt caattgccat tccgtgacgg
     4981 atgagcgaag cgcgggattc tttgccgtag ggctagcgtt gcacggaggt aagccggcgg
     5041 ctgtttgctg tacctcgggc acggccttgc tgaatataca tccggcggta gcggaggctt
     5101 tctatcagaa agttccgctt gtcgtgatat ccgccgaccg ccccgccgca tggatcgggc
     5161 aaatggacgg acagaccttg ccgcaacccg gggtgttcgg ctcgctggtg aagaaatcgg
     5221 tacagctacc ggaaatacat acggatcaag atgaatggta ttgtaatcga ttgatcaacg
     5281 aggctttgtt ggaactgaac catcacggca aagggccggt tcatatcaac gtcccgatct
     5341 ccgagccttt atttcagttc acgacacccg aattgccgaa ggtacgggta atcacccgtt
     5401 atcaaggcct aaacgtgtac gaccggaaat atgacgatct gatcgagcgt ttgaacaaat
     5461 atagcaagcg aatgatgata gcgggacaaa tgagcttgat ctatctcttc gagaagaaaa
     5521 tatgcaagtt actatacaag catttcactt ggctctccga gcacatcggc aaccgtatcg
     5581 taccgggatt gccgatcaag aatttcgacg ccatcctgta cgctacccca gaggaggaaa
     5641 aagagaagct ggttcccgag ctcgtgatca cctacggcgg ccatattgtc tccaagcggc
     5701 tgaaagagtt tttgcggaaa cacccgccta aggagcattg gcatgtctca ttggatgggg
     5761 aggtagcgga tttattcggt agcctgacca cggtgatcga gatggacgct ttcgagtttc
     5821 tggagaaaat cgcttatatg ctggagaata ggcagattga atatccgaag gcttgggaat
     5881 ataaatcccg gaatctgccg gagccggagt tcgcttactc cgaaatggcg gcgatcggtg
     5941 gtttgatacg ttcgcttccg gctgaatctg ccttgcatct ggggaatagc tccaccgtac
     6001 gttacgcgca attgtacacc gtacccgaga cggttgaggt ttgttgtaac cgaggtacga
     6061 gcgggatcga aggctctttg tctacggcca tcggatacgc ctcggcctcg caaaaactaa
     6121 actttatcgt tataggcgat cttagtttct tctatgatat gaacgcattg tggaacggaa
     6181 acttgcacaa taaccttcgc atcctgctct tgaacaacgg aggtggcgag atcttccaag
     6241 ccttgccggg attcaagatg aacgagcgta cgcaccgtta cgtcaccgcc tcccaccaga
     6301 cctcagcgga gggatgggcc acggaaaggg gattctccta ctccgccgtt cataacgccg
     6361 aggagttggc agctgcgatg agcgccttta cccaaacgga gcaaccgagc gaacatcccc
     6421 tattcatgga ggttttcacg gacaaagcgg aagacgtacg attgctcaag gaatattatc
     6481 atcaactaaa aaattcatcc caagcacaaa acatataata tatggaaacg aaaagagaat
     6541 ggacaaccat caaggaatac gaggagatct tatttgattt ctacaacggc atcgcccgca
     6601 ttacgataaa ccgggaacgg tatcgcaacg cttttacccc gactacgacc acggagatga
     6661 gcgacgcctt ttacatctgc cgggaacgtc cggacattaa cgtagtcgtt ctgacaggag
     6721 ccggagatac ggcgttttgc gcgggaggcg atatgaacgt gaaaggacgt ggcggctacg
     6781 tgggtaaaga cggcgtacct cgcttgaacg tattggacgt acaaaagcag atccgctctc
     6841 tcccgaaacc cgtcatcgca gccgtgaacg gtttcgctat cggcggcgga cacgtattgc
     6901 acgtggtttg tgaccttacg atcgcttccg agaacgctat cttcggacag acaggccctc
     6961 gtgtgggtag cttcgacgcc gggttcggct cttcttacct cgcccgtgtg atcggacaaa
     7021 aaaaggcccg tgagatctgg ttcctatgcc gcaagtacaa tgcacaggag gctttggata
     7081 tgggtctggt aaataaggta gtccccttgg ataaattaga ggacgagtac gttcaatggg
     7141 ccgaggagat gatgttgctt agcccgttgg ccttgcgcat gatcaaggcg ggcttgaacg
     7201 ccgagttgga cggacaggcc ggtatacaag agttggccgg agacgctacc atgctttact
     7261 atatgacgga cgaggcgcag gaaggcggca aggcattctt ggagaaacgc cgtccacgct
     7321 tcgaggatta cccgaagttc ccgtaaaggg aattgagaat tgagaattga aaattgagaa
     7381 tgaatggtga aggagaggtt ttataaaaca gaggtggttc cccggtgctt gactttcaag
     7441 cgaccggcag gaacctcacg gggtgtttac acgacccgga aattgtggga ggtccgaatc
     7501 cgcaaggaag acgaaccctc ggttattggt atcggagaat gtgcccccct gccggatctc
     7561 agttgcgatt atggagtgga ttacgagatc acgttatcca aggcttgcct cgatctggaa
     7621 cagaagggat atgttgacac cgaatctttg cgccattacc catccatcct tttcggattg
     7681 gaaatggcca tgcgtcatta tgaacagggt ggttggcggc attacgacac gcccttctcg
     7741 cgggggcaag cgggcatccc cattaacgga ctgatctgga tgggcgatta taagtacatg
     7801 ctggaacagg tagaggaaaa gatgaaggag ggcttccgct gcgtcaagct gaagatcggc
     7861 gctatcgatt tcgaccggga actctcttta ttgaaacata tccgcacgca tttctccgcc
     7921 aaggaaatag agcttcgggt agatgccaac ggcgctttca ctcccccgga ggcgatggat
     7981 aaactgaagc ggctcgccga gatggactta cattccatcg agcagcctat ccgtgccggg
     8041 cagttggaag aaatggcaca ccttgcggca gagtcacccc ttcccatcgc tctcgacgag
     8101 gaactgatcg gctgtaacgc cccggacgag aaacggcggt tgttggaaac tatccatccc
     8161 caatacatta tattaaagcc ttccctccac ggaggtatct ccggatgtac ggaatggatt
     8221 cacttagcgg aagctatctt agggagtacc cctgaacaac ctaaatggtg ggtcacctcc
     8281 gctctggaat cgcaaatcgg actgaacgct atcgcccaat ggtgcgccac gttaggtaac
     8341 ccgctaccgc aaggtctggg aaccggcgag attttcaagg atgataaaca tcggttgatc
     8401 caacgaaaag gagacaccat ctggttcacc aacgaccttt gacctatgcc gatacaagaa
     8461 gatttacagg cattcttagc tgaatggcac gatccctccc cttttctgga agtccagacc
     8521 tccggctcca ccggtacgcc caagcggatg agagtgcgca aggaccggat gctgaacagc
     8581 gcccggctta cctgcgatta tctgggtctt aagaagggcg acaaggccct gttatgtatg
     8641 cccctgcgct atatagccgg aaagatgatg gtggtccgct ccctatacgc cggactggat
     8701 ctggaggtgc gtgaaccctc cggacacccg ttggcggatt ggggggatac gcccctgcgc
     8761 tttgccgcca tgatcccctt gcaggtttac aatacgttgc gagtacccga ggaacgtaaa
     8821 cggctggagc aaacggatat cctgattatc ggcggcgggg cgatcgacgc ggccttggaa
     8881 caggagatac ggcagatgcc aaacacggtt tattccacct acggaatgac ggagacgctg
     8941 tctcacgtcg ccctgcgccg gctgaacggg ccggaagcct cgccctatta ccatcccttc
     9001 ccctcggtga cgttatcctt gtcgccggac aataccttgg tgatagacgc cccattggtt
     9061 tgcgacgagc ggctggtgac gaacgatgtc gcccgcctgc tgccggacgg gagtttcgcc
     9121 attatcggaa ggaaagataa tatcatcaat agcggaggaa tcaaaataca gatcgaggag
     9181 gtggaagagc ggctacggcc ctacctagac ctcccctatg ccatcaccgc cgcccccgac
     9241 cctcggttgg gagaggcggt agtcttacta atcgccccaa ggtcatgtga aacggtatca
     9301 ccccctcggg tgacaccaca catgaaagct atcatgagcg actccgcgca gctatcatgt
     9361 gaggtatcga cagtggctct cgccagcctg cccaagtacc tccgtccaag gcacgtcata
     9421 gaggcaagcg agatccccca aaccggaagc ggcaagatcg atcgtgccgc ctgccgggag
     9481 ctagcgagaa atatcatcac aaaaacacta taaacatgaa aaggattcta acaatcaccg
     9541 cggtctccct attggcctta tcgcctatgt acgggcagga ttcttgccga tacccgcaag
     9601 atcctacctt ggagaaatcg caagcctacg caggatacga ctgcgtcacc ttgctggaca
     9661 gcaccgccgt cacggtacaa cctaccggct cgggggcttt cgccgtatgc aaggctttta
     9721 aggtacagac tcccaaggga gccgtcgcca accgtatcat caaatacgat tacgacccgc
     9781 tgacggcgca tgccgagttt cgttacgcca cgatctaccg tgcgaatggc gacgtgatca
     9841 atctcgacgt gactggggct tgcgactatg ccgcccccgc acgtgccatc tactggggcg
     9901 cccggcagat catgctggaa gtgggccgcc tgcaaccggg agatgtcgtg gagtacgaga
     9961 tcgccaagaa aggtttcacc tacgccttgc tgacggcggg cgacgacgag cgtttcatcc
    10021 ctcctatgcg gggacagttt tacgatatcg tccccttctg ggctaccgag cctaccgtgc
    10081 gtaaggtata ccgggtatcc atgccgatgg agaaagagtt gcaattccag ttctaccaag
    10141 gcgaatgtac ctcttccatg cgatatgagg atggacggaa agtatatacc ttcgcctccg
    10201 acgatatcct tcctttcgcc aaggaaccga atatggtaga cctattcgac gctgccccga
    10261 agctcatgat gtccagcacg ccccgctggg aagataaatc cgtatggttc aataaggtta
    10321 acgaggatta cggaagcttt accgcgatcc cggaagccca aaggaaggta gacgagctga
    10381 tcaaaggcaa gaagacggaa atggagaaga tagccgtatt gacccactgg gtagccgata
    10441 acatccgtta ctccggaatc tcgatgggta aaggcgaggg tttcacgctt cacaacctaa
    10501 agatgaatta taccgatcgt tgcggtgtct gcaaggatat cgccggtacg ttgatcgcct
    10561 tcctccgcat ggccggattc gaggcttacc cggcgatgac catggcggga agccgtgtag
    10621 aaagcatccc cgccgaccat ttcaaccatt gcgtggcggt ggtaaaactg gctagcggca
    10681 cgtatatgcc tctcgacccg acttgggttc ctttctgccg agaattatgg agtagcgccg
    10741 agcaacagca gaactacctc ctgggtgtgc ccgaaggctc cgacctctgc ctgacccctg
    10801 tctccgcccc agaaaaccac tacgtccgca tccacgctga caaccgccta gacgagaaag
    10861 gcacgctccg cggacaattc acgatcaccg ccgagggaca gtccgacagc aatatccgcc
    10921 gcatcttcac caccggatgg caatccgact ggcagaacac gatggagaag caattgctgg
    10981 ccgtatcccc caacgccaaa ctgcttcgtg tagattacgg taaggacccg aagaactatc
    11041 aagcggcccc tatcaagatc acgttctctt atgagatccc cgattatgcg atcatcgccg
    11101 gagaccagat gcttatcaag ccgctagtca tgaataacct ctacaatcaa gtgaagagtt
    11161 tcttgcgtat cgatacgaaa ccggaaaacc gtgcgtatgg attcaaggac gcttgctccc
    11221 gtttggtaga acaagatgag accatccgtc tccccaaagg ctataccctc ctgaacgccc
    11281 cgaagaatga cgccctgcga agcaatgcgg ccgatttcga aggttccctt tcacaggaag
    11341 gcgaccggaa catcgtcttg cgccagaagc tagcgttgaa gaagcgtgtc tacgacgcag
    11401 ccgactggaa aggcttccgt tccgccgtga acgcctataa gagttatggt gactatttga
    11461 ttatcaagaa ataaaaaaag aaagacaatg attaagataa cctataaact gattcttctc
    11521 ctaagcttgt tagcgatgac ggttacttca ttcgccgcat cggaggctga gtacgggaaa
    11581 gtatcgaaag cttggac
//
