LOCUS       gnlProkkaCGDJAKNJ_26   13568 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|CGDJAKNJ_26.
ACCESSION   gnlProkkaCGDJAKNJ_26
VERSION     gnlProkkaCGDJAKNJ_26
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-01 17:37:46
            Original ID  :: gnl|Prokka|CGDJAKNJ_26
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 22858
            Orig. end    :: 36426
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13568
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:8568]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..8568
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..13568
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13568
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             complement(30..1166)
                     /NRPS_PKS="Domain: NAD_binding_4 (98-186). E-value:
                     2.8e-09. Score: 28.3. Matches aSDomain:
                     nrpspksdomains_ctg26_22_NAD_binding_4.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010:NAD-dependent epimerase/dehydratase (Score: 80.5;
                     E-value: 2.5e-24)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg26_22"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 1.5e-09,
                     bitscore: 29.3, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGSRGFVGRNLVSQLHNIRDGKARNYGIAGEELTIYEYDMNSDP
                     AELDVYCKQADFVFNLAGVNRPQDASEFMKGNFGFASTLLDTLKKYGNTCPVMISSSTQ
                     AALDNPYGESKRAGEQLLFEYSRETGAKVLVYRFPNVFGKWCRPNYNSAVATFCNNIAH
                     DLPIRVNDPSVVMHLVYIDDVVDELVSALSGREHRNGDYCEVPVVHTITLGGIVELIRS
                     FRQMPGTLSVPDLSDAFTKKLYSTYLSYLPEERFSYPLKMNVDDRGSFTEIIRTSDRGQ
                     FSVNISKPGVTKGQHWHHTKNEKFVVVSGHGLIQLRKIGTEEIVSFEVSGGRMEVVEMI
                     PGYTHNIVNLSETEDLVTFMWCNECFDPARPDTYFEKV"
     aSDomain        complement(609..872)
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg26_22_NAD_binding_4.1"
                     /evalue="2.80E-09"
                     /label="ctg26_22_NAD_binding_4.1"
                     /locus_tag="ctg26_22"
                     /protein_end="186"
                     /protein_start="98"
                     /score="28.3"
                     /tool="antismash"
                     /translation="ISSSTQAALDNPYGESKRAGEQLLFEYSRETGAKVLVYRFPNVFG
                     KWCRPNYNSAVATFCNNIAHDLPIRVNDPSVVMHLVYIDDVVD"
     CDS             complement(1219..1623)
                     /locus_tag="ctg26_23"
                     /transl_table=11
                     /translation="MNRIVLDTNSLIQCISPKSRYRKIWDCFLDGTNQLCVSDEILNEY
                     EEILERLAGVEIAKLVIDVILNNPYTLFFTPYYNFNLIKSDPDDNKFVDCAIVANAKFI
                     VTEDHHFHILKQYNFPKVSFIGLDDFCHSL"
     CDS             complement(1620..1841)
                     /locus_tag="ctg26_24"
                     /transl_table=11
                     /translation="MAATVLNSVQQHLLKMFAFDGSEERLNEVKEVLTKYFSQKLDDRL
                     NDLWDSGVLNQEKLDELRKIDVRTLPKR"
     CDS             complement(1942..3015)
                     /NRPS_PKS="Domain: NAD_binding_4 (10-144). E-value:
                     2.6e-07. Score: 21.9. Matches aSDomain:
                     nrpspksdomains_ctg26_25_NAD_binding_4.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010:NAD-dependent epimerase/dehydratase (Score: 105;
                     E-value: 8.3e-32)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg26_25"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 2.1e-108,
                     bitscore: 353.8, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="RmlD_sub_bind (E-value: 3.6e-08, bitscore:
                     24.8, seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVFKDKVLLITGGTGSFGNAVLRRFLDSDIKEIRIFSRDEKKQD
                     DMRHHLQNPKVKFYIGNVRDRQSVDGAMMGVDYVFSAAALKQVPSCEFFPLQAVQTNVI
                     GTDNVLESAIAHGVKNVVVLSTDKAAYPINAMGISKAMMEKVAIAKGRALGEEAGTTIC
                     CTRYGNVMASRGSVIPLWVEQIKNGRPITVTDPNMTRFMMTLDDAVDLVIYAFEHGHNG
                     DLFVQKAPAATLDVLAQALKETYAQVDPKYGETEVKTIGTRHGEKLYETLVTREEMAKA
                     VDMGDYYRIPCDTRDLNYDKFFTEGNEDIARIEDYHSHNTARLDVEGMKKLLLKLRFIR
                     EDLGMEEKAKSAEIKSE"
     aSDomain        complement(2584..2985)
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg26_25_NAD_binding_4.1"
                     /evalue="2.60E-07"
                     /label="ctg26_25_NAD_binding_4.1"
                     /locus_tag="ctg26_25"
                     /protein_end="144"
                     /protein_start="10"
                     /score="21.9"
                     /tool="antismash"
                     /translation="ITGGTGSFGNAVLRRFLDSDIKEIRIFSRDEKKQDDMRHHLQNPK
                     VKFYIGNVRDRQSVDGAMMGVDYVFSAAALKQVPSCEFFPLQAVQTNVIGTDNVLESAI
                     AHGVKNVVVLSTDKAAYPINAMGISKAMME"
     CDS_motif       complement(2932..2988)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg26_25_0001"
                     /evalue="1.70E-03"
                     /label="PKSI-KR_m1"
                     /locus_tag="ctg26_25"
                     /protein_end="28"
                     /protein_start="9"
                     /score="11.1"
                     /tool="antismash"
                     /translation="LITGGTGSFGNAVLRRFLD"
     CDS             complement(3030..3776)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_1"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg26_26"
                     /sec_met_domain="Glycos_transf_1 (E-value: 1.1e-12,
                     bitscore: 39.9, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSWKELMIEKARNLYLYYYFKRGVTAFWTENPYISEKVKHLFPTI
                     KAYTVSNYYNQVFDDENTQIEHALPSFDGCTLLSINAPYPHKNLAIAIEVARYLKKHYS
                     EFSFRFVFTVTENDLPPIPSYLREHFCLIDKVSVAECPSLYRQADIMFQPTLLECFTAT
                     YVEAMRMQVPILTTDLPFAHGLCGNAAVYYSPLDAEDCAKSIYKMAVDTSFQDYLVGEG
                     IKQLKSFDNYNRRAEKLIDLISNLDD"
     CDS             complement(4204..4293)
                     /locus_tag="ctg26_27"
                     /transl_table=11
                     /translation="MKTNFNIRSIIVINKIIINFFFRQYRWYL"
     CDS             complement(4300..5016)
                     /locus_tag="ctg26_28"
                     /transl_table=11
                     /translation="MSRGISEKEQRWLLVLSQVIEVLDKNNLLYFIDTGTLLGAVRDKM
                     FIPWDNDIDLAVIGGDTSTTNLLKVSKLLYALGFYVTLTKKEIAICSRDGVNLGIKLYK
                     KQASHYEACMGKVYRHRLFYSINLYLSGEVLYKKGFSFKYKAISLFVKFSQVFKLKLSC
                     IWQMKLLFWAKYDEKTVIIPFEFVDAIIDYNFYNIIVKVPNKPERYLAYRYGENWKVPK
                     QDYDYMIDDKSIINID"
     CDS             complement(5001..6095)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Fe-ADH"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg26_29"
                     /sec_met_domain="Fe-ADH (E-value: 4.6e-76, bitscore: 247.9,
                     seeds: 218, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEQRFFLGESSIKELIPILQEYTPDHIFLVRGKNSYEKCGAQAVL
                     ESVFVKLACGVTEFFDFEANPKIEDMEKGLSLLKEYPTNMIIAIGGGSVLDMAKLLRFF
                     YSYSGNPTGGEFEKKRQLIPLITLPTTAGTGSEATHFSVLYKDKVKYSVEHDAILPDVA
                     IVYPKFTYGNSKYLTSCTGFDALAQAIEAYWNVNATEESDKYAAKAIKLLWPNLPLVVN
                     SPTAEARNKVSEGSYWAGRAINITKTTAPHAFSYSFTTDYGYPHGHAVALTFPFFMRYN
                     IGNSDILLNPNINPYLYKIKMQKMLQWLNMECVDVAIAMKEYIRNLGLDIDISQIDISK
                     IVSSVNIQRLINNPYKVEAICLEE"
     CDS             complement(6102..7232)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 69;
                     E-value: 6e-21)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg26_30"
                     /sec_met_domain="TPP_enzyme_N (E-value: 8.8e-17, bitscore:
                     53.2, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.5e-20, bitscore:
                     65.5, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MISPNIFVDSLGAMQMDFFTGVPDSLLKNICAYLTDHLASEHNII
                     AANEGAAIGLATGYYLATRKIPVVYMQNSGLGNAVNPLMSLTDKEVYNIPLLLLIGWRG
                     EPGVKDEPQHIKQGKVTLPLLEAMGIRYAVLSQDEKKFISQLNVAKSYMDETREPFAFV
                     IQKDTFLEYSSENCEDERLSLKREAAIHFIAASLTEKDIIISTTGMISRELFEYRESTS
                     LEHERDFLTVGSMGHASQIALGIALKKRDCKVYCFDGDGSTLMHMGSLAIVGSLHPENY
                     VHVVFNNGAHDSVGGQPTVALDIDLCKIAQACGYEIVLSVSDNEGLCEALKKIQQIRGP
                     ILLEVKVRKGARKNLGRPANTPIQNKEAFMLFLDNL"
     CDS             complement(7264..8568)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 202.6;
                     E-value: 1.3e-61)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg26_31"
                     /sec_met_domain="CTP_transf_like (E-value: 8e-12, bitscore:
                     37.5, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 4e-119, bitscore:
                     388.9, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 1.3e-63, bitscore:
                     206.6, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEKKKVYVGMSADIIHPGHLNIIHEASKLGHVTVGVLTDSAIASY
                     KRLPYLNFDQRSLIVLNLKGVDEVIPQTTLDYVPNLELIRPNFVVHGDDWKEGIQQETR
                     QRVIDTISKWGGKVIDVPYTKGISSTLLNTRLKEIGTTPEIRLKRLKRLIAAKSIVRIC
                     ESHSGLTGLIIENTSVEVNGVKREFDGMWSSSLTDSTSKGKPDIEAVDLTTRLHDLNDA
                     LECTTKPVIFDGDTGGKIEHFVFTVRTLERLGISAVIIEDKIGLKKNSLFGTDAVQTQD
                     TIEGFCDKIQAGKRAQITDDFMIIARIESFIAGKGLDDALGRALAYIKAGADGIMIHSK
                     DKSGEDIKNFCLALRKIHKSIPIVVVPTTYNHISEDELASWGVNVVIYANHMLRSAYPA
                     MLNTAKSILANARSYEANDLCMPIKEILELIPGTK"
     CDS             complement(8531..9661)
                     /locus_tag="ctg26_32"
                     /transl_table=11
                     /translation="MKVTTDNSFYNLVIGNNKMILLLMLACIVTYYYAMKFALVIELYG
                     AGEGRMMRFEAGELFTSNLEVYLYDFLIKPFTQFVMLIVACMLLSKIKRRILLLSVLFL
                     FLYASVGNGRGGLIVFLFYCFIIYYLRRELYYINLLASKRKKWNFGVVSFVCLFVGVGI
                     IVVVISYMTAQRMGFDTFSAEVVKIGFEELKSQAVWYFLGPFRALDYSFRANYESITGF
                     WYGRATMGGIDNLLKLVIHYLGGSYTIAHDEIGHLLQNSKISVGNGIIFNYAYTNIIFH
                     YLDFGYVGVLLFPFLYGFIVRYSIYKFTQKPTLLTLGIMIYLVYISMFNIFSWEFQKPS
                     SIIYVLLLLFFQYVYSHKFVILKLNGKKKGLCRHEC"
     CDS             complement(9907..10839)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg26_33"
                     /sec_met_domain="Glycos_transf_2 (E-value: 3.5e-25,
                     bitscore: 80.8, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNGSITVSICCLTYNHEKYIRQCLDGLIMQKTEFDFEILVHDDAS
                     SDATQSIINEYVVAYPNLIKPILQIRNQYSQGISPLRQILFPLVKGKYVALCEGDDYWT
                     DPLKLQKQVNAMESDHSLAGCAHQSLVFYENGTPSHMFHHVKKQILKTKDLLDVRLFHT
                     ASFLFKKEVLDYIKDFNSSLYAGDRFLFLACSLKGNILYMPDVMCCYRKNAMGVTSRVS
                     YSLHVLDLKVPEYFHNKDLKFPYYRYLAFVHRAIFSESLDISLKKYIYHFTLFVKYSFS
                     YFPKNLKDIYKALYVSFWWLTKGQKYRIK"
     CDS             complement(10840..11835)
                     /NRPS_PKS="Domain: NAD_binding_4 (91-233). E-value: 3e-07.
                     Score: 21.7. Matches aSDomain:
                     nrpspksdomains_ctg26_34_NAD_binding_4.1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010:NAD-dependent epimerase/dehydratase (Score:
                     114.5; E-value: 1.1e-34)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg26_34"
                     /transl_table=11
                     /translation="MKKKIIIFGATGNTGSYLLEYALNFFNKEEYEIIASGRRETTFFS
                     KRGIPYYSVDITKEEDFDKLPMENIHAVMLLSAQIPSYMDTYCPIKYLDSIVIGGFNVL
                     EYCRKCHVDRIIYTQTVFDISLYSHDTILKPDMKPNFSYTGDHAIYVISKNTALDLIEH
                     YYQEYGLKKFIFRLPTIYSYSPYPYYFPNGVKTKRPIYQMIENAQKGLPIEIWGDPHYA
                     KDMVHVNDFSQMLCKAVEVEQESGFYNVGTGMPITLEEQIRTIISVFSPKESPSEVIYR
                     PDKVCGGGYIMNIENAKKELGYVPQYDCRKLFEDYKSEMEIKRFAELRLK"
     aSDomain        complement(11137..11562)
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg26_34_NAD_binding_4.1"
                     /evalue="3.00E-07"
                     /label="ctg26_34_NAD_binding_4.1"
                     /locus_tag="ctg26_34"
                     /protein_end="233"
                     /protein_start="91"
                     /score="21.7"
                     /tool="antismash"
                     /translation="YLDSIVIGGFNVLEYCRKCHVDRIIYTQTVFDISLYSHDTILKPD
                     MKPNFSYTGDHAIYVISKNTALDLIEHYYQEYGLKKFIFRLPTIYSYSPYPYYFPNGVK
                     TKRPIYQMIENAQKGLPIEIWGDPHYAKDMVHVNDFSQ"
     CDS             complement(11832..12797)
                     /locus_tag="ctg26_35"
                     /transl_table=11
                     /translation="MMSIGGYFELEIREGKHFHQGAIKLSTARQCFEYILKARRYTKVY
                     IPYYTCDVIIEPLMKLNVKYEYYHINSLLDPVFDKKIESSEAFLYTNYFGLKQDTVLYL
                     SRFYPNLIVDNAQAFFAKPIEGVDTFYSARKFFGVPDGAYLYTTALLDIDFPIYNPIDN
                     INYLIGRITDSAEGYYKDFQESEERMSNQEIHRMSVLSDKILSSLDYVSIIERRRFNYH
                     LLYSALTAFNKFDFSISENQNVPLIYPFYTSKAGLRQQLILEHVYVPQYWQNVVNKIDA
                     KCLEYSIANNMIALPIDQRYDEKTMNILIEKISNLNNHLS"
     CDS             complement(12794..13483)
                     /locus_tag="ctg26_36"
                     /transl_table=11
                     /translation="MKLGIMQPYFMPYIGYFQLIKAVDKYVVYDDVNYIKGGWVNRNNI
                     LVNGEKKMFTITLKGASAYKHFNEIEIGDDFRKFMKTLELNYSKAPFYHETMELLYRII
                     MFPNRQLALFLANSFKEILDYLNIQTEILLSSDLPKDCSLKGKDKVLHICKLLSADTYY
                     NAIGGKQIYNKEDFMQNGINLKFVDTIIKRYPQQSKEFVPYLSIIDVLMNNSKEETCML
                     LDSFSLQ"
ORIGIN
        1 ccatctgttc ctatattctt taactcgttt caaacttttt caaaataagt gtccggacgt
       61 gccgggtcga aacactcgtt gcaccacatg aaggtcacca ggtcttccgt ttccgaaagg
      121 ttgacaatgt tgtgcgtata gccgggaatc atctccacga cctccatcct cccgccgctt
      181 acctcgaagc tgacaatttc ctccgtacct atcttgcgga gctgtatcag accgtgcccg
      241 ctcaccacca caaacttctc gttcttggta tggtgccagt gctggccttt cgtaacgccc
      301 ggcttggaga tgttcaccga gaactgcccg cggtcggaag tacggataat ctccgtaaaa
      361 ctgccgcggt cgtccacatt catcttcagg ggatagctga accgttcttc aggcaggtat
      421 gagaggtatg tggaatagag tttctttgta aaggcatcgc tcaaatccgg gacggacaag
      481 gtaccgggca tttgtctgaa agaccttatc agttccacaa tgccgcccaa ggtaatggta
      541 tgcaccacgg gtacttcgca ataatccccg ttgcggtgtt ccctgccgct cagggcagag
      601 acaagctcgt ccaccacatc gtctatgtaa accagatgca tcaccaccga agggtcgttc
      661 acccggatgg gcaagtcatg ggcgatgttg ttgcagaaag tggccaccgc gctgttatag
      721 ttggggcggc accatttgcc gaaaacattc gggaagcggt acaccagtac ctttgcaccc
      781 gtttccctgg agtactcgaa caacagctgc tcccctgccc gcttcgattc accgtaaggg
      841 ttgtcgagtg cggcctgcgt ggaagaggaa atcattaccg gacaggtatt gccgtacttc
      901 ttcaatgtat caagcagcgt ggaggcgaag ccgaagttcc ctttcataaa ctcagacgca
      961 tcctggggac ggttcacgcc tgccagattg aagacaaagt cagcctgttt gcaatagaca
     1021 tccagttcgg cagggtcact gttcatgtca tattcgtaaa tggtaagttc ctcacctgca
     1081 atgccgtaat tgcgggcttt cccgtcacgg atgttgtgca gctgggatac aaggttccgg
     1141 ccgacaaacc ctcgggagcc ggtcactaag attttcataa actaatgggt tctgtttgtc
     1201 acagaaaaga gaagatattc atagtgaatg acagaaatca tccaaaccta taaaacttac
     1261 ttttgggaaa ttatattgct tcaatatatg aaaatgatga tcttccgtaa caataaactt
     1321 ggcattagcc acaattgcac agtccacaaa cttattatca tccggatctg attttatcag
     1381 attgaagtta taataaggag taaagaacaa agtataagga ttattgagaa tgacatcaat
     1441 caccagctta gctatttcca cacctgccaa acgttctaat atttcctcat attcattaag
     1501 aatttcatca gaaacgcata actgattcgt tccatccaaa aagcaatccc aaatcttacg
     1561 gtacctgctt ttgggagaaa tgcactgtat caagctattt gtatctaata caattctatt
     1621 catctcttcg gaagtgtacg gacatcaatt tttctcagtt catcaagttt ttcttggttt
     1681 aaaactcccg aatcccataa gtcattcaag cggtcatcta acttctgaga aaaatatttg
     1741 gtcaacactt ctttaacttc attcaatcgc tcctccgaac catcaaaagc aaacatcttc
     1801 aaaagatgtt gttgaactga atttaatact gttgctgcca tattctcaat tattagtttc
     1861 aatatggcaa agatagtttt tttttctaaa ggaacaatac attccctctt tctttcctgt
     1921 tgtattattc aaattaaaga cttattcact cttgatttcc gcgctcttcg ccttttcctc
     1981 cattccgagg tcttcgcgga tgaaacggag tttcaaaaga agctttttca tgccctccac
     2041 atccaggcgg gcagtgttat ggctgtgata gtcctctata cgggcaatat cctcattgcc
     2101 ttccgtgaag aacttgtcat agttcagatc acgggtgtcg caggggatgc ggtagtagtc
     2161 gcccatgtcg acagcctttg ccatctcttc gcgggttacc agtgtctcat acagtttctc
     2221 gccgtggcgc gtgccgatgg tcttcacctc cgtctcaccg tatttcggat caacctgcgc
     2281 gtatgtttcc ttcaaggcct gcgccagtac atccaaggtg gcggcaggag ccttctgcac
     2341 gaacaggtca ccgttatgtc cgtgctcaaa cgcatagatt accagatcca cggcatcgtc
     2401 cagcgtcatc atgaagcggg tcatgttagg atccgttacc gtaatgggcc tgccgttctt
     2461 tatctgctcc acccacaagg gaattacaga accgcggctt gccatcacat tgccgtaacg
     2521 ggtacagcag atggttgtac cggcttcctc acccaacgca cggcccttgg ctatggcaac
     2581 cttctccatc atggctttgc tgatacccat ggcattgatg gggtaagccg ccttgtcggt
     2641 agaaagcact actacgtttt tcaccccatg cgctatggcg gattccagta cattgtccgt
     2701 accgatcaca ttggtctgca cagcctgcaa cggaaagaac tcgcagctgg gaacctgctt
     2761 caaagcggcg gcggaaaaca cataatccac tcccatcatg gcaccgtcta cagactggcg
     2821 gtcacggaca ttaccaatgt aaaattttac tttgggattt tgcaggtgat gacgcatgtc
     2881 atcctgcttt ttctcgtcac gactaaaaat acgaatctcc ttgatatcag aatcaaggaa
     2941 acgacgcaat acagcgttac caaaactgcc ggtacctccg gttataagga ggactttgtc
     3001 tttaaatact gacataaata taatatgtat taatcatcca aattcgatat caaatcgatt
     3061 aatttttctg ctctccgatt ataattatcg aaggacttaa gttgttttat tccttctccg
     3121 accagataat cttgaaagga tgtgtctaca gccattttat aaattgattt ggcacagtct
     3181 tctgcatcta acggcgaata gtacacagct gcatttccac ataatccatg agcaaatggc
     3241 aaatctgtag ttaaaattgg cacttgcatt cgcatcgctt cgacatatgt ggcagtgaaa
     3301 cattcaagta aagttggttg aaacattata tctgcctgac gatataagga agggcattct
     3361 gctacactaa ctttatcaat cagacagaaa tgctctcgca aataagaagg aataggtggc
     3421 aagtcattct ctgtcaccgt aaaaacgaat cgaaaactaa attcggaata atgtttttta
     3481 agatatcgag cgacttcgat agcaattgct aaattcttat gaggataagg agcatttatg
     3541 gacagtaaag tacaaccgtc aaaagacggt aaggcatgtt ctatttgagt attttcatca
     3601 tcgaaaacct gattataata attcgataca gtataggctt ttatggtagg gaacaagtgc
     3661 tttactttct ctgaaatata aggattctca gtccaaaaag cagtcacacc acgtttgaag
     3721 taataatata aataaagatt tctcgccttt tctatcatta gttccttcca agacatacgt
     3781 tgaaaatagg gagaatcgtt caaaacgaga tgggatctgg caaatccaca tagatgctta
     3841 catttcggct tccatcttgc aggtccgaat atggtaagaa ctccaccaat attgtgtctg
     3901 gttaccaaat tatccatagc cttatcacgt ccccaaaaca atgtatacca actgtttcgt
     3961 atatcatgac gcactacagt gacatttttg tattccgata ccctatcagc agtatcatcc
     4021 atacatgagg ataatactaa aaaaaaatca tgttggggaa ttgtattcaa acaagaacaa
     4081 accgaatcag cgacttgaag ccctccacct ttcttgagat tggagcaatt tattagaatg
     4141 ttcatttgtt ccgagaatat aatatataag tgcccaattt tggtgtataa atgaaagtgc
     4201 tatttataaa taccatctat attgtctaaa gaaaaagttg attataattt tattaattac
     4261 aataatactc cttatgttga aatttgtttt catatttttt taatcaatat ttataataga
     4321 cttgtcatca atcatataat catagtcttg tttgggaacc ttccaatttt caccatatct
     4381 atatgctaga tatctttctg gcttatttgg cactttcaca attatattat aaaaattata
     4441 atcaataatt gcatctacaa actcaaaagg aataatcacc gtcttttcat catacttagc
     4501 ccaaaacaat aacttcattt gccaaataca agacaatttt aacttaaaga cttgactaaa
     4561 cttcacaaag agtgagatag ctttatactt aaaagaaaag ccttttttat acaggacctc
     4621 tccagagagg tataaattta tagaataaaa tagtctatgt ctataaactt ttcccataca
     4681 tgcttcataa tgacttgctt gctttttata taatttaatt cctaaattta ccccgtctct
     4741 agaacagata gcaatttctt tctttgtcaa agtgacgtaa aagcctaaag catataacaa
     4801 ttttgacact ttaagcaaat tagtagtaga tgtatctcct ccaataactg ctaaatcaat
     4861 atcattatcc caaggaataa acattttatc tctaacagct cctaaaagag taccagtatc
     4921 aataaaatat aataaattat ttttatcaag aacttcaata acttgtgata atactaacaa
     4981 ccatcgttgc tccttttcac ttattcctct agacatatcg cttcaacttt atatggattg
     5041 tttattaatc tttgaatatt aacagaagat acgattttcg atatgtcaat ttgagatatg
     5101 tcaatatcta atcccaagtt tcttatatac tctttcatag cgattgcaac atctacgcat
     5161 tccatattta accactgtaa cattttttgc attttaatct tatataagta aggatttata
     5221 ttaggattca ataagatatc cgaatttcca atattatatc tcataaaaaa gggaaatgtt
     5281 aatgctactg catgtccatg cggatatcca taatcagttg taaatgaata cgaaaaagca
     5341 tgtggagctg tagtcttagt tatattaatt gcacgaccag cccaataaga gccttccgaa
     5401 accttattcc tagcctccgc tgtaggagaa tttacaacca atggcaaatt aggccataag
     5461 agtttaattg ctttcgccgc atatttatcc gactcttccg tagcattcac attccaataa
     5521 gcttctatcg cctgcgctag agcatcaaag cctgtacaag atgttagata ttttgaattt
     5581 ccataagtaa attttggata tacaatcgct acatccggaa gaatagcatc atgttctact
     5641 gaatatttta ctttatcttt atataaaaca gaaaaatgag ttgcttcact acctgtacca
     5701 gctgtagtag gaagtgttat taatggaatt aattgtcgct tcttttcaaa ctcccccccc
     5761 gtaggattac cagaatagga ataaaaaaaa cgaagcaatt ttgccatatc taatacacta
     5821 cctccaccta tagcaataat catatttgtc ggatattctt tcaataatga aagtcctttt
     5881 tccatatctt caattttagg atttgcttca aaatcaaaga attccgtcac gccacaagct
     5941 aatttaacaa aaacagattc taacacagcc tgtgcaccac atttctcata agaatttttt
     6001 cctcttacaa gaaatatatg atcaggagta tattcttgca agataggaat caattctttt
     6061 atagaagact ctcctaaaaa aaaacgctgt tccataattc tctataaatt atctaagaaa
     6121 agcatgaatg cctctttatt ttgtatagga gtgttggctg gtcttcccaa attcttacga
     6181 gctccctttc gaacctttac ttccaacaaa atagggccgc gtatttgctg tatcttttta
     6241 agagcttcac ataaaccttc gttatcagaa acagacaata ctatttcata accacaagct
     6301 tgagcaattt tacataaatc aatatctaaa gcgactgttg gttgtccccc cacagaatcg
     6361 tgagcgccat tattaaagac tacgtgtaca tagttttccg gatgtaaaga accgacaatt
     6421 gctaacgaac ccatatgcat caaagtggaa ccatctccat caaagcaata aactttacag
     6481 tctctctttt taagagctat tcccaatgct atctgcgacg cgtgccccat agaacctaca
     6541 gtcaaaaaat ctctctcatg ttctaaagaa gtagattcac gatattcaaa taattcacgt
     6601 gatatcatac ctgttgtcga tattataata tctttttctg ttaatgaagc tgctatgaaa
     6661 tgaatagcag cttcgcgttt caaagacaac cgttcatctt cacaattttc agaactatac
     6721 tctaagaaag tgtctttctg aattacaaaa gcaaaaggct ctcttgtctc atccatgtaa
     6781 gattttgcaa cattaagttg agatataaac ttcttttcat cttgagataa aacagcatat
     6841 ctgataccca ttgcctcaag taatggaagt gtgacttttc cctgcttaat atgttgtggc
     6901 tcatctttca caccaggttc accacgccaa ccaattagca ataacaatgg aatattataa
     6961 acttctttat ccgtcaatga cattaaagga tttactgcat ttccaagacc tgaattctgc
     7021 atataaacaa ctggaatttt cctcgtagcc aaataatatc ctgtagccaa acctatagca
     7081 gcaccttcat tagcggcaat aatgttatgt tcagaagcaa ggtgatctgt taaatatgca
     7141 catatattct tcaataaaga atcgggaact ccagtaaaaa aatccatctg catagcgcca
     7201 agagagtcta caaaaatatt aggagaaatc ataataataa gaatttaatt ttaaagagtc
     7261 tatttactta gtccctggaa tcaattccag aatttcttta ataggcatgc ataagtcatt
     7321 ggcttcataa gagcgtgcat tggcaagaat ggacttcgcc gtattaagca tagcgggata
     7381 tgcacttcta agcatatgat ttgcatatat tacaacattt actccccaag aagccaattc
     7441 atcttctgat atatggttat aagtagttgg aacaaccact atcggaatgg atttatgtat
     7501 tttgcgtaaa gcaagacaga agttctttat atcctcacca gacttatctt tgctatggat
     7561 cataatccca tccgcacctg ctttaatata tgctaatgca cgtcctaaag catcatctaa
     7621 accttttcca gcaataaaac tttcaatacg agctattatc ataaaatcat ccgttatctg
     7681 agcacgttta cccgcttgaa ttttatcaca aaacccttca attgtatcct gggtctgaac
     7741 agcgtctgtt ccaaaaagcg agttcttctt cagacctatt ttatcctcga taataacagc
     7801 tgatatccct aaacgttcca gcgtgcgaac agtaaataca aaatgttcta ttttaccacc
     7861 tgtatcacca tcaaaaatta ctggtttggt agtacactcc aaagcatcat tcaaatcatg
     7921 aagacgagtt gtcaagtcaa cggcttcaat atcaggctta cctttagaag tcgaatcagt
     7981 aagactactg gaccacatcc catcaaattc acgcttaact ccgttgactt ctacactggt
     8041 attttctatt atcaaacctg ttaacccact atgagattca cagatacgaa caatactttt
     8101 agcagcaatt aagcgtttaa gtcgcttcaa acgaatttcg ggagtggttc ctatttcctt
     8161 caacctagta ttcaataaag tggaagaaat acctttcgta taaggaacat ctatcacttt
     8221 tccaccccat ttagagatag tatcaatcac acgctggcga gtttcttgtt gaataccctc
     8281 tttccagtca tcaccatgta ctacaaagtt aggcctaatc aattccaaat tcggaacata
     8341 atcaagagta gtttgaggta ttacttcatc aacacccttc aaattcagaa ctatcaatga
     8401 gcgctgatca aaattcaagt aaggcaaacg cttgtaactg gcaatagctg aatctgttaa
     8461 tacaccaacc gttacatgcc ccaattttga agcctcatga atgatattca aatgacctgg
     8521 atgaataata tcagcactca tgccgacata aacctttttt ttttccattt aattttaata
     8581 ttacgaattt atgagaataa acatattgaa aaaatagcaa caacaaaaca taaataattg
     8641 aggaaggctt ctgaaattcc cacgaaaaaa tattgaacat tgatatatag accaaatata
     8701 tcataatacc aagagtcagt aatgttggtt tttgagtaaa tttataaata ctatatcgta
     8761 cgataaagcc atataaaaat gggaataaaa gaacgccaac gtaaccaaaa tccaaataat
     8821 gaaatattat attagtgtat gcataattaa agatgattcc attcccaact gaaatttttg
     8881 aattttgcaa aagatgacct atttcatcat gagcaatggt ataacttcct cctaaataat
     8941 ggattacaag ttttaataaa ttatcaattc cacccattgt tgcccttcca taccaaaacc
     9001 cggttatcga ttcataatta gctctaaatg aatagtctaa agctctaaat ggacctaaaa
     9061 aataccatac ggcctgactt tttagttctt caaaacctat ttttacgacc tcagcactaa
     9121 atgtatcaaa tcccattctt tgagctgtca tatatgaaat aaccacaact attattccaa
     9181 cgccaacgaa caagcataca aaagaaacta caccaaaatt ccattttttc cttttgctgg
     9241 ctaacaaatt gatatagtac aattctcttc ttaaataata aatgataaaa caataaaata
     9301 gaaaaacaat caatccccca cgcccattac caacagatgc gtataaaaac agaaaaagca
     9361 ccgatagcaa cagaattcta cgtttaatct tagaaagtag catacacgct acaattagca
     9421 taacaaactg tgtaaaaggt tttattagaa aatcatatag atatacttct aaattactcg
     9481 taaaaagttc accagcctca aatctcatca tccgaccttc gcccgctcca tatagttcaa
     9541 taactagagc aaacttcatt gcgtaataat aagtaacaat acatgccaac ataagaagta
     9601 atatcatctt attattgcca ataaccagat tataaaaact attatctgtt gtaaccttca
     9661 atcgtatttt ttttattttt ccaaaacaaa gaaatcccca attaaacgcc caaacattga
     9721 tcaataataa catatatgtt ttcattgaca cagaatatag ttcagctgga tcaaaagtag
     9781 aaataacaat agcagttccc caccacaata aatatatgaa acttattttt cttgaaaaag
     9841 aatcaattat aagcctatta gatatcaaaa tctgaattaa gaatagaata agaaaaatta
     9901 tagcaatcat ttgattctat acttttgtcc ctttgtcaac caccagaaag aaacatataa
     9961 agccttatag atatctttca gattcttagg aaaataagaa aaagaatatt tcacaaataa
    10021 agtaaaatga tatatatatt tctttaagga aatgtcaagt gattctgaaa atatagctct
    10081 atgaacaaat gccaaatatc tgtaataagg aaatttcaaa tctttattat gaaaatattc
    10141 aggaactttt aggtctaata catgtaatga ataagaaact ctagaagtaa ctcccattgc
    10201 attcttccta taacaacaca ttacatctgg catatataaa atatttcctt tcaacgaaca
    10261 agccaaaaac agaaaacgat ctccagcata taaactacta ttgaaatctt taatataatc
    10321 aagtacttct tttttaaaaa ggaaagacgc tgtatgaaaa agtcttacat ccaataagtc
    10381 tttagttttt aaaatctgtt ttttcacatg atgaaacata tgggatggag ttccattctc
    10441 ataaaaaact aaagattgat gcgcacaacc tgctaacgaa tgatcactct ccattgcatt
    10501 tacttgtttt tgtaacttca acggatcagt ccaataatca tccccctcac aaagcgcaac
    10561 atatttacct tttactaaag gaaataatat ttgacgtaac ggagaaatac cttgagaata
    10621 ctggtttcga atctgaagaa ttggtttaat aagattagga tatgccacaa catattcatt
    10681 aataatactc tgagtagcat cagaagacgc atcatcatga acaagaattt caaaatcaaa
    10741 ttctgttttt tgcattataa ggccatctaa acactgcctt atatattttt catgattata
    10801 cgtcaagcaa catatgctaa ctgttattga accgttcatt tattttaatc ttaattcagc
    10861 aaaacgcttt atttccattt cacttttata atcctcaaac aacttacgac aatcatattg
    10921 aggcacatat cctaattctt tctttgcatt ttcaatgttc attatgtacc caccaccaca
    10981 aactttgtct ggtctatata taacttcaga tggtgactcc ttaggcgaaa aaacactaat
    11041 aatagtgcga atttgttctt ctaatgtaat tggcattcct gtacccacat tataaaagcc
    11101 actttcttgt tccacctcaa cagctttaca caacatttga ctaaaatcgt taacatgaac
    11161 catatccttt gcataatgag gatctcccca tatctctata ggtagtcctt tctgagcatt
    11221 ttcaatcatt tggtaaatag gtcgcttcgt cttgactcca ttaggaaagt agtacggata
    11281 agggctatag ctatatattg ttggaagcct aaaaatgaat tttttcaaac cgtattcttg
    11341 ataataatgc tctatcaagt ctaaagcagt atttttggaa attacatata tagcatgatc
    11401 acccgtatag ctaaaatttg gtttcatatc gggttttaaa atagtatcat gagaatacaa
    11461 tgaaatatca aaaacggttt gagtataaat tatcctatct acatgacatt tgcggcaata
    11521 ctctaataca ttaaatcctc ctattacaat agaatctaaa tactttatgg ggcaataagt
    11581 atccatataa gaaggtattt gagcagagag tagcataact gcatgtatat tttccattgg
    11641 aagcttatca aaatcttctt ccttcgtaat gtccacagaa taatatggta ttcccctttt
    11701 ggaaaaaaaa gtagtttcgc gacgtcctga agctattatt tcatactctt ccttattaaa
    11761 gaaatttaat gcgtattcta acaaataaga ccctgtatta ccggttgctc caaaaataat
    11821 aattttcttt ttcatgataa atggttattt aagttagata ttttttcaat taatatattc
    11881 attgtttttt catcatatct ctgatctata ggcaatgcaa tcatattatt cgcgattgag
    11941 tattccagac atttagcgtc tatcttattc actacgtttt gccaatattg aggtacatat
    12001 acgtgctcta atattaattg ttggcgaagc ccagctttgc tcgtataaaa aggatatatc
    12061 aacgggacat tttgattttc agaaatacta aaatcaaatt tattaaatgc agttaatgca
    12121 ctgtagagaa gatgataatt aaaacgacgc ctttcaatta ttgagacgta atccaaagaa
    12181 gacaaaattt tatcagacaa tacagacatt ctatgtatct cttgatttga catcctttct
    12241 tcagattctt gaaaatcttt ataatacccc tctgcagagt cagttatacg ccctatcaag
    12301 tagttaatat tatcaatagg attataaatc gggaaatcaa tatccagtaa cgcagttgtg
    12361 tacaaataag cgccatctgg aactccaaaa aatttacggg cagaataaaa tgtatctacc
    12421 ccttcaattg gttttgcaaa aaaagcttgt gcattatcaa ctattaagtt aggataaaac
    12481 cgagataaat aaagaacagt atcttgtttt aagccgaaat aattagtata tagaaaagcc
    12541 tctgagcttt ctattttttt atcaaacaca ggatccagta aactatttat atgataatat
    12601 tcatacttta catttaattt catgagaggt tctattatca catcacaagt gtaatatgga
    12661 atatacactt ttgtataccg tctagctttt aatatatact caaagcattg acgagcagta
    12721 ctcagtttta ttgcaccttg atgaaaatgt tttccttcac gtatttccag ttcaaaatag
    12781 ccacctattg acatcattgt aaactaaatg aatctaataa catacaagtt tcttctttag
    12841 aattattcat tagtacatct attattgata aatatggaac aaattcttta gattgctggg
    12901 gatacctttt tattatcgta tctacaaatt tcaaattaat accattttgc ataaagtctt
    12961 ccttattata gatttgtttt ccacctatag cattataata agtatctgcc gatagtaact
    13021 tacaaatatg aagaacttta tcctttcctt ttaaagagca atctttaggt aaatctgaag
    13081 atagcaatat ttcagtctga atatttagat aatctaaaat ttctttaaaa ctattagcca
    13141 agaagagagc caattgtcta tttggaaaca taattatcct atacaacaat tccattgttt
    13201 catgatagaa aggagcttta gagtaattca attccaatgt tttcataaat ttacgaaaat
    13261 catctcctat ctctatttca ttgaaatgtt tataggcact agcccccttc aaagtgatag
    13321 taaacatttt cttttcacca tttaccaata tattgttacg attcacccac cctcctttaa
    13381 tataattaac atcatcgtat acaacgtatt tatcaacagc cttaattagc tggaaataac
    13441 ctatataagg cataaaataa ggttgcatta tacctaattt catttcaata tcagatttaa
    13501 aattctttca acatcttcat tcgacaatcc acaatacatt ggcaagcaga ttacactttt
    13561 tgccattt
//
