LOCUS       c00068_gnlPro..        15064 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|KIJMFKND_68.
ACCESSION   c00068_gnlPro..
VERSION     c00068_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 01:55:22
            Original ID  :: gnl|Prokka|KIJMFKND_68
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 1287
            Orig. end    :: 16351
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15064
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[11287:15526]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..14239
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..15064
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15064
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             complement(1761..2315)
                     /locus_tag="ctg68_3"
                     /transl_table=11
                     /translation="MEKSKDTWTVLSSEYLHRAPWLTVRKDHVVLPNGNHIPSYYILEY
                     PNWVNTIAITRDGQFVFIRQYRHGIQETSYELCAGVCEEEDGSPMVSAQRELLEETGYG
                     NGVWKEFMQISPNPSTHTNITYCFLTTDVEKISEQQLEDTENLTVHLLSLQEVKELLQQ
                     GSIRQALMAAPLWKYMAERII"
     CDS             complement(2330..3409)
                     /locus_tag="ctg68_4"
                     /transl_table=11
                     /translation="MKDFQIQAIGLMSGTSLDGLDVCCCTFRQQAGKWSFHIDCAKGYS
                     YPDAMKQILGTGAQTMSALEFITFHSSYGKFLGERVNEFMQEFGVHPDIIASHGHTIFH
                     EPQKRIMYQIGDGAAIAAETRIPTVSDFRRLDIMLGGQGAPLVPIGDRLLFADYDFCLN
                     IGGFSNISFEQDGRRIAFDISPVNYVINHYCRQIGLEFDRDGEIARQGNICQELLDELN
                     GMDFYHQSGPKSLGREWVETLVYPMLERYGLSMENMLRTFYEHAAWQISRIITARPLPD
                     GNGKLLITGGGAFNKFLIERIDALCPCEIVIPSRQIIEYKEALIFAFLGALYMVDTPGC
                     LASVTGATTDNIGGMLFKI"
     CDS             complement(3425..4780)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_M20"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg68_5"
                     /sec_met_domain="Peptidase_M20 (E-value: 1.9e-38, bitscore:
                     122.0, seeds: 360, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEIKKYITENEPKMLEDLFSLIRIPSISAKPEHHDDMLACAERWA
                     QLLLEAGADEALVMPSKGNPIVFGQKIVDPDAKTVLVYAHYDVMPAEPLELWKSDPFEP
                     EIRDGHIWARGADDDKGQSFIQVKAFEYLVRNELLQTNVKFIFEGEEEIGSPSLESFCQ
                     EHKELLKADVILVSDTSMLGADLPSLTTGLRGLAYWEIEVTGPNRDLHSGHFGGAVANP
                     INVLCQIISQVTDAEGRITVPGFYDDVEEVPQAERDMIARIPFDEEKYKKAIHVKALFG
                     EKGYSTLERNSCRPSFDVCGIWGGYTGEGSKTVLPSKAYAKVSCRLVPHQDHHKISRLF
                     ADYILDIAPDSVQVKVTPMHGGQGYVCPITLPAYQAAEKGFEKAFGKKPLAVRRGGSIP
                     IISTFEQVLGIKTVLMGFGLESNAIHSPNENIPLDIFRKGIEAVVEFYLNYK"
     CDS             complement(4790..5866)
                     /locus_tag="ctg68_6"
                     /transl_table=11
                     /translation="MFNSFGNILRLTSFGESHGKGVGGVIDGFPAGIVIDMDFVQAELD
                     RRRPGQSRITTARKEGDKVEFLSGIFEGKSTGCPIGFIVWNQNQHSDDYNNLKEVYRPS
                     HADYTYKVKYGIRDHRGGGRSSARETISRVVAGALAKLALKQLGIHITAYTSQVGPIRL
                     EENYTAYDLDLIETNPVRCPDPAKAKEMEELIFKIKGEGDTIGGVVTCVVKGCPIGLGQ
                     PVFGKLHAALGAAMLSINAAKAFEYGDGFKGLKQKGSEQNDVFYNNNGRIETRTNHSGG
                     IQGGISNGQDIYFRVAFKPVATVLMEQHTVNIDGVDTTLKARGRHDPCVLPRAVPIVEA
                     MTAMTLLDYYLIDRTTQL"
     CDS             6241..7434
                     /locus_tag="ctg68_7"
                     /transl_table=11
                     /translation="MKKNLFYLFALICSMSLFTACSDDDDDKVVCPVPQTEFTVATGLN
                     LTYNGGSMLGKKVTFTPDASDATKATLVLAGNLDLSGILTREAASGSFGAGVFPGSPVV
                     TLPVTLNIQGDECSFSGTSETDYCTFDYAGKVTASSLKLDLTNVALKNSALSGTTWVPT
                     PLNSDYTEEPIHLIWESNKNVEVMPGWELPIQTILTLALRMPLIDAGGDDKVNVEDMLC
                     SVLHDITLGVDGNISASYVDAAQGGTSVVKTPANVAQYVVLSDTQMKVYLNLDAIIANV
                     KRLGSSTKAIDMSEILSQAVTSLLPLVTDGVPLTYEKNEGKLKVYLNTDLLLPLMKNIV
                     APLFSDEEFVNMLIEAMKADPDFGSMAGMAEGMLKGLPEIINETTRLEVGLNLTAAK"
     CDS             7554..8831
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SDH_alpha"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg68_8"
                     /sec_met_domain="SDH_alpha (E-value: 1.8e-62, bitscore:
                     201.1, seeds: 645, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTETERRQIIALVKSEVIPAIGCTEPIAVALCVAKAAEVLNKRPE
                     KITVLLSANILKNAMGVGIPGTGMIGLPIAVALGALIGKSAYQLEVLKESTPDAVEAGK
                     RFIEEKRIHISLKNDMEEKLYIEVCCEADTNKATAIIAGGHTCFTYITRNGDILLDKQI
                     ASCIEEEDVLDLTLRKVYDFAMTTPLDDIRFILDTARLNKTAAERSFEGEYGHGLGKIL
                     RGTYEHRIMGDSVFSHILSYTSGACDARMAGAMIPVMSNSGSGNQGISATLPVLVYAEE
                     NGKSEEELIRALMLSHLTVIYIKQSLGRLSALCGCVVAATGSSCGITWLMGGTYEQVAY
                     AVQNMIANLTGMICDGAKPSCALKVTTGVSTAVLSAIMAMENRCVTSVEGIIDEDVDQS
                     IRNLTKIGSKGMNETDKLVLEIMTSK"
     CDS             complement(8939..9511)
                     /locus_tag="ctg68_9"
                     /transl_table=11
                     /translation="METVENKYITVAYKLYSIENGEKDFEEEAPVEHPFQFISGLGMTL
                     EPFEAQIKDLQIGDKFDFTIPASEAYGEYDDDHVIDLPKEIFMIEGEFDSDRVVEGAVI
                     PLMTSEGQRINGSVVEVKEDVVVMDMNHPLAGCDLNFTGEVVESRPATNEELAEVARMM
                     GGGCGSCGCGDCGDGCGDHECGGGCCH"
     CDS             10001..11803
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ILVD_EDD"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg68_10"
                     /sec_met_domain="ILVD_EDD (E-value: 3.5e-219, bitscore:
                     718.4, seeds: 918, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKHQLRSSFSTQGRRMAGARALWTANGMKKEQMGKPIIAIVNSFT
                     QFVPGHVHLHEIGQFVKEEIEKLGCFAAEFNTIAIDDGIAMGHDGMLYSLPSRDIIADS
                     VEYMVNAHKADAMVCISNCDKITPGMLMAAMRLNIPTVFVSGGPMEAGEWNGQHLDLID
                     AMIKSADESVGDKEVAQIEQHACPTCGCCSGMFTANSMNCLNEAIGLALPGNGTIVATH
                     ENRKKLFEDAARLIVENAFRYYEEGDESVLPRSIATREAFLNAMTLDIAMGGSTNTVLH
                     LLAVAHEAGADFKMDDIDMLSRKTPCLCKVAPNTQKYHVQDVNRAGGIIAIMDELAKGG
                     LVDTNVRRVDGMTLAEAIDRYSITSSNVCKEAIKKYSSAAAGKFNLVLGSQNASYKELD
                     TDRATGCIRDLEHAYSKDGGLAVLKGNIAQDGCVVKTAGVDESIWKFTGPAKVFDSQDA
                     ACDGILGGKVVSGDVVVITHEGPKGGPGMQEMLYPTSYIKSRHLGKECALITDGRFSGG
                     TSGLSIGHVSPEAAAGGNIGKIKDGDIIEIDIPNRSINVKLTDEELAARPMTPVTRNRE
                     VSKALKAYASMVSSADKGAVRLID"
     CDS             11895..13646
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg68_11"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.1e-47, bitscore:
                     151.4, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MADNNKKSNFSSLSQGEGRGEALITGAEALMRSLEHQGVKTIFGY
                     PGGSIMPVFDALYDHRKELNHILVRHEQGATHAAQGFARVSGEVGVCLVTSGPGATNTI
                     TGIADAMIDSTPIVVIAGQVGTNFLGTDAFQEVDLVGITQPITKWSYQIRRAEDVAWAV
                     ARAFYVAKSGRPGPVVLDFAKNAQVEKTEYAPTKVDYVRSYLPVPEMEPEAIRQAAELI
                     NGAERPLVLVGQGVELGEAQQELRAFIEKAGMPAGCTLLGLSALPTNHPLNKGMLGMHG
                     NLGPNINTNKCDVLIAVGMRFDDRVTGKLETYAKQAKIIHFDIDPAEIDKNVKTDVAVL
                     GDCKETLAAVTQLLEPANHQEWIDSFRQYEEVEEEKVIRPELHPAGKALSMGEVVRAVS
                     EATHNEAILVTDVGQNQMMSARYFKYSKERSIVTSGGLGTMGFGLPAAIGATFGRPDRT
                     VCVFMGDGGLQMNLQELGTIMEQKAPVKMILLNNNFLGNVRQWQAMFFNRRYSFTPMMN
                     PDYMKIASAYDIPARRVMTREELAKAIDEMIATDGPFLLEACVEEEGNVMPMTPPGGSV
                     NQMLLEC"
     CDS             13679..14239
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg68_12"
                     /sec_met_domain="ALS_ss_C (E-value: 7.9e-20, bitscore:
                     60.8, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKKLYTIIVHSENFAGLLNQVTAVFTRRQINIESLNVSASSIKG
                     VHKYTITAWTDKDTIEKVTKQITKKIDVLQAHYFTDDEIYQHEIALYKITTPTLEEKPE
                     VSKVIRKYNARIVEVNAVFAIVEKNGMSEEITNLYEELRQLDCVLQFVRSGRVAITTSC
                     FERVNEYLADREAKYRQSKHQEL"
     CDS             14236..14988
                     /locus_tag="ctg68_13"
                     /transl_table=11
                     /translation="MMSENNKIGTYKFVAEPFHVDFTGRLTMGVLGNHLLNCAGFHASD
                     RGFGIATLNEDNYTWVLSRLAVELDEMPYQYEDFSIQTWVENVYRLFTDRNFAIIDKEG
                     KKIGYARSVWAMISMNTRKPADLLALHSGSIVDYVCDEPCPIEKPSRIKVASKEPVATL
                     VAKYSDIDINGHVNSIRYIEHILDLFPIEMYKEKRIRRFEMAYVAESYYGDELTLFMDD
                     AGEGVYDVEVKKNGSEVVCRSKVMFTEK"
ORIGIN
        1 gcgtcggatt tccagccttt gtacgaagca ggcttgtcgc gtgccattgg cgactggctg
       61 ctcgggatga atgccacccg cctctacacc atgaagtatg ggcagaaccg gcaggtactt
      121 tctatcggcc gtgtgcagac gccgacactg gcgctgattg taaaccgtca gttggaaata
      181 cagaattttg ttcccaagca atactgggag ctgaagaccg tctatcgaga taccactttc
      241 tccgccatcc tccggaaaag tgaggaggaa ctggtattgg aagccgagaa gcagaaagag
      301 gctatagctg ccgggaagaa acctaaaaaa gaagaagaga atcggggtat cgaccccatt
      361 accgaccgcg aacgtgggct tgctttattg gaccagatta agaattctcc ttttaccgtg
      421 acggatgtca ccaagaaaga ggggagggag gcgccactcc gcttgtttga cttgacttct
      481 ttacaagtgg aatgtaacaa gaagtttgcc tattccgctg atgagacgct gaaaatcatc
      541 cagtctttgt atgagaagaa agtggctacc tatccacgtg tagacactac ctatttgagt
      601 gatgacatct atcccaaatg ccccggcatc ttgaaaggtc tgcgtgatta cgagacattt
      661 acagcccctt tgacaggaac tgcattgttg aagtccaaaa aggttttcga taactcgaag
      721 gtaacagacc accacgccat tattcctacc ggccagcatc cgcagaatct gacggatatg
      781 gagcgtcgcg tattcgattt gatagcacgc cgtttcattg ctgtattcta tcccgattgt
      841 aagtttgcca ctaccaccgt attgggcgag gtagagagca tagagttcaa ggccaccggc
      901 aagcagattc tggaaccggg ttggcgtgtt atcttcggca ccccctcggc acaatcgcag
      961 gaggagaaag aggagaaggg agaagaggag aatgtgcttc cggcttttgt gaaaggagaa
     1021 agcggaccgc acgtccccga tttgtatgag aagtggacgc agccgccccg gccttatacg
     1081 gaagccaccc tgctgcgtgc tatggaaacg gcgggcaagc tggtggataa cgacgaactg
     1141 cgtgatgcgc tgaaggaaaa cggtatcggt cgtccatcta cccgtgcagc catcatcgag
     1201 acgctgttca agcgaaacta tatccgcaag gaaaagaaga atctgatagc cacccctacc
     1261 ggtgtggagc tgatacagat tatccatgag gagctgttga agtcggcgga actgaccggt
     1321 atctgggaga aaaagctacg tgagatagaa aggcggacat ataatgccgg acaattcttg
     1381 gaagaattga agcagatggt atcggaagtc gtgatgagtg tactttctga taacagcaac
     1441 cgccacatca ccatccaagc gcctgctccc gaaaagggca gtaaggcttc tgccaagaca
     1501 gaggctgccg ataagccgaa aaaggagccg aagaaaagaa caccgagaga gtctgccgcc
     1561 gcaggtaaaa agacggagca ggcttcgggc gctgtggcag cttcaagtac ggaggcttcc
     1621 gtacaagctg acgatttcgt cggtcagcct tgtccgcttt gcggaaaagg taccgttatc
     1681 aaggggaaaa cggcttacgg ttgttccgaa tggaaatccg gatgcacatt ccgtaagccg
     1741 tttgaataag ggtaatcaca ttaaataatt ctctccgcca tgtatttcca gaggggagca
     1801 gccatcagcg cctggcggat gcttccttgc tgcagcaatt ccttgacctc ctgcaaggaa
     1861 agcaggtgta cggtcaggtt ttccgtatct tccaactgtt gctcggagat tttctccacg
     1921 tccgtagtca ggaaacagta ggtaatgttg gtgtgggtac ttggattggg agagatttgc
     1981 atgaactctt tccatactcc gtttccatag ccggtttctt ccaaaagttc ccgttgtgcg
     2041 gaaaccatcg gagagccgtc ctcttcttcg catacccctg cacagagctc ataggacgtt
     2101 tcttgtatgc catgccggta ttggcggata aagacaaatt gtccatcacg ggtgatggca
     2161 atggtattca cccagtttgg atattccaat atataatagg aggggatgtg gttgccgttg
     2221 ggtagcacta catggtcctt acgcacagtg agccacggag cccgatgcag gtattcgctg
     2281 gataagacgg tccaggtgtc ttttgatttt tccataatgg taaaattgac tatattttaa
     2341 acagcatccc tccgatatta tctgtcgtgg ctcccgtcac cgaggcgagg catccgggtg
     2401 tgtccaccat atagagggca cccaggaaag caaagattag ggcttccttg tattctatga
     2461 tttgccggct gggaatcacg atttcacacg gacacaaggc gtcgatacgt tctatgagga
     2521 acttgttgaa tgcacctcca ccggtaatca gcagttttcc gttaccatcg ggcaaggggc
     2581 gggcggtgat gatgcgtgat atttgccagg cggcatgctc gtaaaaggta cgtagcatat
     2641 tctccatact caagccataa cgctcgagca tgggatatac cagcgtttcc acccactccc
     2701 gtcccaatga cttcggtccg gactgatggt agaaatccat tccgttcagt tcgtccagca
     2761 gttcttggca gatgttgcct tgccgtgcta tctcgccgtc acggtcaaat tccaatccta
     2821 tttgccggca gtaatggttg atgacgtaat tcaccggact gatgtcaaaa gcgatgcgcc
     2881 gcccgtcctg ctcgaatgag atgttggaga aaccgccgat attcaaacag aagtcgtagt
     2941 cggcaaaaag caaccggtcg ccaataggta cgagtggagc gccctgccca cccagcatga
     3001 tgtccagccg ccggaaatcc gaaacggtag gtatacgggt ttcagcggca atggcggctc
     3061 cgtcacctat ttggtacatg attctctttt gaggctcatg gaagatggta tgcccgtggg
     3121 aggcgataat atcggggtgg actccaaatt cttgcatgaa ctcgttgaca cgttcaccga
     3181 gaaactttcc ataggagctg tggaaagtga tgaactccaa agcactcatt gtctgtgcac
     3241 cggtacccaa tatctgcttc atggcgtcgg ggtagctata gccttttgca cagtctatgt
     3301 ggaaagacca ttttccggct tgctgccgga aagtgcaaca acatacgtcc agcccgtcaa
     3361 gggaagtgcc ggacatcagg ccgatggctt gaatttggaa gtctttcatc ctgattttct
     3421 tgttttattt ataattgagg tagaattcga caacagcttc tattccttta cggaagatgt
     3481 ccaacggtat attctcatta ggtgagtgga tggcgttgga ttcgagcccg aagcccatca
     3541 gaacggtttt gatgcccagt acttgctcga aagtggagat gatggggata cttccacccc
     3601 gacgcactgc cagcggtttc tttccaaaag ctttttcaaa acctttttcg gcggcttggt
     3661 aggcgggtag ggtgatggga catacatatc cttggcctcc atgcatcgga gtgactttta
     3721 cctgtactga atccggcgct atgtccagaa tgtagtcggc aaagagccgg gatatcttgt
     3781 ggtggtcctg gtggggaacc aaccggcagg ataccttggc gtatgccttg gatgggagca
     3841 cggtcttgga cccttcaccc gtatatccgc cccagatgcc gcatacgtcg aaagacggac
     3901 ggcaactgtt acgttccagc gtactgtaac ctttctctcc gaaaagtgct tttacatgga
     3961 tagccttttt gtatttctct tcgtcgaaag gaatgcgggc tatcatgtcg cgctcggctt
     4021 ggggaacttc ttccacatcg tcatagaagc ccggtacggt gatacgtccc tctgcgtccg
     4081 tcacttggct gattatctgg caaagtacat tgatggggtt ggcaacagca ccgccgaagt
     4141 gaccgctgtg taggtcgcgg ttggggccgg tcacttctat ttcccaatag gctagtccgc
     4201 gcagtccggt ggtcagtgaa ggcaggtctg caccaagcat gctggtgtcc gaaaccagaa
     4261 tgacgtctgc tttcagcaac tctttgtgct cctggcagaa gctttctaag ctgggcgaac
     4321 cgatttcttc ttctccttcg aagatgaatt ttacgttggt ttgcagcagt tcgttgcgta
     4381 cgaggtattc aaacgctttc acttgtatga aagattgccc tttgtcatca tcagcaccac
     4441 gtgcccagat atgtccgtcg cgtatttccg gctcaaaggg gtcgcttttc caaagttcga
     4501 gaggttcggc tggcatcacg tcgtagtggg catataccaa tacggtcttg gcgtccgggt
     4561 ctacgatttt ctgtccaaaa acaatcgggt tacctttgga gggcattacg agggcttcat
     4621 ccgctccggc ttcgagcagc aactgtgccc agcgttcggc gcaggcaagc atatcgtcgt
     4681 gatgctcggg tttggcactg atgcttggaa tgcgaatgag gctgaacaag tcttccagca
     4741 ttttaggctc gttctcggtg atgtatttct ttatttccat gggtgaatat tatagttgtg
     4801 ttgttctgtc aatcaggtaa taatccaaca atgtcattgc tgtcattgct tccacgatgg
     4861 gtactgcgcg tggcaataca cacgggtcat ggcgtcctcg ggctttcagg gtggtgtcta
     4921 caccgtcaat gttcacggtg tgttgctcca tcagtacggt tgccacgggt ttgaaggcta
     4981 cacggaaata gatgtcttgc ccgttactga ttccaccttg tataccgccc gaatgattgg
     5041 tgcgggtctc gatacgtccg ttattgttgt agaacacatc attctgctcc gagcctttct
     5101 gctttaatcc cttgaaaccg tctccatact cgaatgcttt tgctgcattg atgctgagca
     5161 tggctgctcc aagtgctgca tggagcttgc cgaatacggg ttgtcccagt ccgatggggc
     5221 atcctttgac gacacaagtc accactcctc cgatggtatc tccttctccc tttatcttga
     5281 agatgagttc ttccatttct tttgccttcg ccgggtcggg gcagcggacc ggattggtct
     5341 ctatcaggtc gaggtcgtat gcggtataat tttcttcaag gcggatagga cctacttgtg
     5401 aagtgtacgc cgtgatgtgt atacccagct gcttcagcgc caatttggcc agggcacccg
     5461 ctactacacg cgagattgtt tcacgggctg atgaacgtcc gcctccgcgg tggtcgcgga
     5521 tgccatattt cactttataa gtatagtcgg catgtgacgg tcggtagact tctttcagat
     5581 tattgtaatc gtcagaatgt tggttttggt tccatacaat gaatcctatg gggcagcctg
     5641 tggattttcc ttcgaagatg ccggagagga actccacttt atcaccttct ttccgggcgg
     5701 tagtgatacg tgactgtccg gggcggcgtc ggtcgagctc tgcctggacg aaatccatat
     5761 caatgactat tcctgcaggg aatccgtcta tcactcctcc cacgccctta ccgtgcgatt
     5821 ccccaaaact ggtaagacgg agaatatttc caaatgagtt gaacatatca aatgctttaa
     5881 aggtttatat atgaggttaa tgtgccaata cgctttataa gaaatgcttt tgactttata
     5941 aagataacaa ctttttttca taaaacgttt aaggaaataa gataaaaagt cttttccgca
     6001 taaagttgcc tgcctttgcc agagtttggt caatggcttg ttctttataa aaatggctta
     6061 ctctttatga aatctgcatc cgaatttcac tcgtaatgat gaaaaaagga acatttattt
     6121 tttagaaaag accttgtact gtaaccttaa aaagtgttac tttgcacctt tgatttaaaa
     6181 tgggaaatta atagctccct tgggaagctt tttattaact aaacaagtac tcaaaaaagt
     6241 atgaaaaaga atttatttta tttatttgca ttgatctgtt caatgagttt attcacggct
     6301 tgtagtgatg atgacgatga caaggtagta tgtcctgtgc cgcaaacaga gtttacagtt
     6361 gcaacaggtt tgaacttgac ttataacggt ggatcaatgt tgggaaagaa agtaactttt
     6421 actccggatg cttctgatgc aaccaaggct actttggtat tggctggcaa tttggatctt
     6481 tccggtattc ttacacgtga agcggcttcc ggttcttttg gtgcaggcgt attccctggt
     6541 tctccggttg taacccttcc ggttactttg aatatacaag gtgatgaatg ttcgttttcc
     6601 ggcacaagtg agaccgatta ttgtactttt gactatgcag gaaaggttac tgcttcttcc
     6661 ttgaaattag atttaactaa tgtcgcattg aaaaattccg ctttatccgg aacaacttgg
     6721 gttcctacac cccttaattc tgattatacg gaagaaccga ttcatttgat ttgggaatcc
     6781 aataagaatg tagaggtaat gcctggctgg gagctaccga ttcaaacaat tttgacgtta
     6841 gctcttcgta tgcctttaat tgacgcaggt ggtgatgata aagtgaatgt agaggatatg
     6901 ttgtgtagtg tgttgcatga tattactttg ggtgttgacg gtaatatttc agcttcttat
     6961 gttgatgccg ctcagggagg tacctctgtt gttaagactc ctgcgaatgt tgcacaatat
     7021 gtagttctca gtgataccca aatgaaggta tatttgaatc tggatgccat cattgccaat
     7081 gtaaaacgtc tgggcagttc taccaaggct atagatatga gtgaaatttt atctcaggct
     7141 gttacgtctt tgcttccttt ggtaactgac ggtgtgcctt tgacttacga aaagaacgaa
     7201 ggtaaattaa aggtttattt gaatacggat ttgttattgc ctttgatgaa aaatatagtt
     7261 gctcctttat tctcggatga ggagtttgta aatatgctta tcgaagcaat gaaagctgat
     7321 cctgattttg gaagtatggc cggtatggca gaaggtatgt tgaagggttt acctgaaata
     7381 attaatgaaa caactcgttt ggaagttggt ttgaacttga ctgccgctaa ataacttttt
     7441 tttcgatatg gaattttccc tcctttgtct cctgattttc aggttataga ggagggattt
     7501 ttgtttgttt tttcctacat ttgcatgata aataatcaaa ttgtagaaat gatatgacag
     7561 aaacggaaag acgacagatt attgctttgg ttaaatctga agtaattcct gccattggtt
     7621 gtacagaacc tatagctgtg gcattgtgtg tagcaaaggc tgcggaagtg ctgaataagc
     7681 gtcccgaaaa gataactgta ttgctgagtg ccaatattct gaaaaatgca atgggagtgg
     7741 gtattccagg tacggggatg attggattac cgattgctgt ggcgcttggc gccttaatag
     7801 gtaagtcggc gtatcaattg gaggttttga aagaaagtac tcctgatgca gtggaggcag
     7861 gaaagcgttt catagaagaa aagcgtattc atatatcttt aaaaaacgat atggaagaga
     7921 agctttatat agaagtatgt tgtgaagctg atacgaacaa ggcaacagct attattgccg
     7981 gtgggcatac ttgttttact tatataacgc gcaacggtga catcttattg gacaaacaaa
     8041 ttgcctcttg tatcgaagag gaggatgtat tggacttgac tttacgcaaa gtgtatgact
     8101 tcgccatgac aaccccatta gacgacatcc gttttattct tgatacggca cgactgaaca
     8161 agactgccgc cgaacgttcc ttcgaaggtg aatatggtca tggactaggt aaaatcctac
     8221 gtggcactta cgaacaccgg attatgggcg acagtgtctt ctctcatatc ctttcttaca
     8281 cttcgggagc atgtgatgcc cgtatggccg gtgccatgat tccggtgatg agcaattccg
     8341 gcagtggcaa tcaagggata tctgctaccc ttcccgtact ggtctatgcc gaagaaaatg
     8401 gaaaatcgga agaagaattg attcgtgcct tgatgttgag ccatttaaca gtaatctata
     8461 tcaagcagag tttgggacgc ttatctgcct tatgcggttg tgtggttgct gctacgggtt
     8521 ccagttgcgg tataacttgg ctaatgggag gaacttatga acaggtggca tatgctgtgc
     8581 agaacatgat tgccaatctt accggaatga tttgtgatgg tgccaaaccc agttgtgcat
     8641 tgaaagtaac taccggagtt tcaaccgcag tgctttcagc catcatggcc atggaaaacc
     8701 gttgtgtgac ttccgtagaa ggtattattg atgaggatgt ggatcagagt atccgtaatc
     8761 tgacaaaaat cggttctaaa ggaatgaatg aaacggataa attggtattg gagataatga
     8821 caagtaaata atatagaatt tgaaaattaa agaattaaaa attaaagaat taccatgcgg
     8881 catgcttaat actgtgtagt ctgattcttt aatttttaat tctttaattt ttaattcttt
     8941 agtggcagca tccgcctcca cattcatggt cgccgcatcc gtcgccacag tcaccacaac
     9001 cgcagctgcc gcaaccgcca cccatcatac gggcaacttc agcaagctct tcgttcgtag
     9061 ccggacggct ttccaccact tctccggtaa agttcaaatc acaacctgcg agtggatgat
     9121 tcatgtccat tacaactacg tcttccttta cttctactac acttccattg atgcgttgac
     9181 cttcagaagt catcaagggg atgacggcgc cttccactac acggtcgctg tcgaattctc
     9241 cttctatcat gaagatttct ttggggaggt caataacatg gtcgtcgtca tattcaccat
     9301 aagcttctga tgccggaatg gtaaagtcga atttatcgcc tatctgcaag tcttttatct
     9361 gggcttcaaa gggttcgagt gtcattccca gacctgagat aaactgaaaa ggatgctcta
     9421 cgggtgcttc ttcttcgaaa tctttttctc cgttttcgat tgagtacagc ttatatgcta
     9481 cggtgatgta cttgttttct actgtttcca ttaattttct atctttattt aattagtaaa
     9541 tacttttttt tgagtatttg aagagacaaa gatacgaatt atttgtttcg ggatgtagag
     9601 agcctttggt aattttcaga ttattaaatg gtttcaatga ttggcaatac atttacattg
     9661 gctgtctgaa tggttctatt tagaactgtt aagtgataaa ataggatttt agggcgatat
     9721 tttcttacga ttattcatat ttatcttatt tttttcttca atttgtttgg agattataaa
     9781 aaagccctta cctttgcagc acgtttgaaa caaaaaagaa gaattaagtt atgaatttac
     9841 atacatctat taacctggca gtcctgcata ttattcgcgt cgtggtggtg gcatcaagag
     9901 cgtgagaaag gttatgtatg tattcgtacg ttagaagata atttattaag cctttctcac
     9961 tatagtggga gaggcttttt cattaaaagg agatttgaaa atgaagcatc agttacgcag
    10021 ctcgttcagc acacaaggtc gccgcatggc gggagcccgt gcattgtgga cggcgaatgg
    10081 tatgaagaag gaacagatgg gtaagcccat tatcgctata gtcaattcat ttacacaatt
    10141 cgtccccggg catgtacatc tgcacgaaat aggccagttt gtaaaggaag agattgaaaa
    10201 actggggtgt tttgctgcgg agttcaatac gattgccatt gacgacggta tcgctatggg
    10261 acacgacggt atgctttatt ccctgccttc aagagatatc attgccgata gtgtggagta
    10321 tatggtaaat gcccataagg cagatgctat ggtttgcatc agtaactgtg acaagattac
    10381 tccggggatg ctgatggcgg ctatgaggct gaatataccg actgtgtttg tttcaggcgg
    10441 tccgatggaa gccggggaat ggaacggaca gcatttggat ttgattgatg ccatgattaa
    10501 atctgctgat gaaagtgtgg gcgataaaga ggtggcacag attgagcaac atgcctgccc
    10561 cacttgcgga tgctgctcag gcatgtttac cgctaattcc atgaattgct tgaatgaagc
    10621 gattggattg gcactgcccg gtaacggcac gattgtagcc actcacgaaa atcgcaagaa
    10681 actatttgag gatgcagcca ggttgattgt agagaatgcc tttagatatt atgaagaagg
    10741 ggatgagagt gtactcccgc gcagtattgc tacccgcgag gcatttttga atgccatgac
    10801 gctggatatt gcgatgggcg gttccactaa tacggtactt catttgttgg ctgtggctca
    10861 cgaagccgga gcggatttta agatggacga cattgacatg ctctcccgca agaccccctg
    10921 cttatgcaag gtggctccca atacccaaaa gtatcatgta caagacgtta accgtgccgg
    10981 tggcatcatt gccatcatgg atgagcttgc caagggcgga ttggtcgata cgaatgtccg
    11041 ccgtgtggat ggaatgacgt tggcagaggc aatcgaccgg tatagtatta ccagctctaa
    11101 tgtatgtaaa gaggcaatca agaaatactc cagtgcggca gccggaaagt tcaatctggt
    11161 actcggctca caaaatgcgt cttataagga actcgatacg gaccgtgcga ccggttgtat
    11221 ccgtgatttg gaacatgcat acagcaagga tggcggtctg gcggttttga agggaaatat
    11281 agctcaggac ggttgcgttg tcaagactgc cggtgtagac gagagtatct ggaaatttac
    11341 ggggccagcg aaagtcttcg actcacaaga tgcggcttgt gacggtattc tgggtggaaa
    11401 ggtggtcagt ggagacgtcg tcgtcatcac tcacgaaggg ccgaaaggtg gaccgggtat
    11461 gcaagagatg ctttatccta cttcttatat caaatcccgc catctgggta aggagtgtgc
    11521 attgattacc gacgggcgtt tcagtggtgg tacttccgga ctaagtatcg gacatgtttc
    11581 tcccgaagcg gctgccggtg gtaatatcgg caagattaag gatggggaca ttatcgaaat
    11641 tgatataccg aaccgttcta tcaatgtgaa gttgacggat gaagagcttg cagcacgccc
    11701 tatgactccg gtaacccgca accgtgaagt ctccaaagca ttgaaagcat atgccagtat
    11761 ggtgagttcc gctgacaaag gggctgtgag gctgattgat taaaagcccc cctttccgaa
    11821 agcgagggga ggagagaatg aaacaaattt ttcaagctac tattgagctt ttaaatataa
    11881 tgaatagata aagtatggct gataataata aaaagagtaa cttttcctcc ctctcccaag
    11941 gagagggtcg gggtgaggct ctaataacag gcgcagaagc attgatgcgc tctctggagc
    12001 atcagggagt aaagactatt ttcggttatc cgggagggag catcatgccg gtattcgatg
    12061 ccttatacga ccaccggaag gaattgaacc acatcttggt tcgccatgaa caaggagcaa
    12121 cccatgcggc acaaggcttt gcacgtgtat caggcgaggt tggcgtttgt ctggttacca
    12181 gtggaccggg tgctaccaat actatcacgg gcattgcaga tgccatgatt gacagtacgc
    12241 ctatcgttgt cattgccggc caggtaggga cgaacttctt gggtacggat gcatttcagg
    12301 aagtggactt ggtaggcatt actcagccta tcacgaaatg gagttaccag attcgtcgtg
    12361 cagaagatgt ggcctgggca gtggcacgtg ctttctatgt ggcaaagagc ggacgtccgg
    12421 gaccggtcgt gctggatttt gctaaaaacg cccaagtgga gaaaacagaa tatgcgccta
    12481 ctaaggtgga ctatgtccgt agctatcttc ccgttcccga aatggagccg gaggccatac
    12541 ggcaggctgc tgaattaata aatggtgcgg aacggccttt ggtgctggta ggacaaggcg
    12601 tggagctggg agaagcccag caagagcttc gtgctttcat tgagaaagcc ggaatgcctg
    12661 ccggatgcac tttattggga ctttccgcat tacctacgaa ccatccgttg aacaaaggaa
    12721 tgcttggtat gcacggtaac ctggggccca atatcaatac caataaatgt gatgtcctta
    12781 tcgccgtagg catgcgcttt gatgaccgtg tgacgggtaa attggaaaca tatgccaagc
    12841 aggcgaagat tatccacttt gatattgacc ctgccgaaat agataagaat gtaaagaccg
    12901 atgttgctgt cctgggagat tgcaaagaga cactggctgc cgttacccaa ttgctggaac
    12961 ccgccaacca tcaggaatgg attgacagtt tccggcaata cgaggaagtg gaagaggaaa
    13021 aggtaatccg tccggaatta catccggcag gaaaagcgct aagcatgggt gaggtggtgc
    13081 gtgctgtgag tgaggctacc cataacgagg cgatattggt gactgatgtc ggccagaatc
    13141 agatgatgtc cgcccgttat ttcaaataca gcaaggaacg tagcattgtt acttccggtg
    13201 gcctgggtac tatgggcttc ggccttccgg cagctatcgg tgccactttt ggacgtccgg
    13261 accgcacggt atgcgtattc atgggagacg gcggcttgca gatgaacctg caggaactgg
    13321 gtaccatcat ggaacaaaag gctccggtga agatgattct gttgaacaat aacttcctgg
    13381 gcaatgttcg tcaatggcag gcgatgttct tcaatcgtcg ttattcgttt actccgatga
    13441 tgaatccgga ttatatgaag attgcttcgg catatgatat tcctgcacgc agggtaatga
    13501 cccgcgagga gctggcaaaa gcgattgacg agatgatagc gactgacgga ccattcctgc
    13561 tcgaagcttg tgtggaggaa gaaggaaatg taatgccgat gacacctccg ggcggttcgg
    13621 tcaatcagat gttgttggaa tgctgaagtc atgcgaaatt aaagaattta ctctatctat
    13681 ggataaaaaa ctatatacaa tcattgttca ttcggaaaac tttgccggtt tgctgaatca
    13741 ggtgacggct gtgtttaccc gccggcagat aaacatcgag agtttgaatg tatcggcctc
    13801 ctccatcaag ggggtacata aatataccat taccgcttgg acggataagg ataccattga
    13861 aaaggtgacc aagcagatta ccaagaaaat agatgtgctg caagcccatt atttcacgga
    13921 tgatgaaatc tatcagcacg agattgccct ttataaaata acgaccccta cgctggaaga
    13981 aaaaccggag gtgtccaaag taatccgtaa gtacaatgcc cgtattgtgg aggtgaatgc
    14041 tgtatttgcc attgttgaga agaatggcat gagtgaggaa ataaccaatc tttatgagga
    14101 gttgcgccag ttggattgcg tacttcagtt cgtccgttcg ggtcgcgtag ccattacgac
    14161 cagctgcttt gagcgtgtca atgaatatct ggcggaccgt gaagcaaaat atcgtcaaag
    14221 taaacaccag gaattatgat gagcgaaaac aataagatag gtacctacaa gtttgttgcc
    14281 gaaccgtttc atgtcgactt taccggacgg ctgaccatgg gagtattggg caaccatttg
    14341 ttgaattgtg cgggtttcca tgccagcgac cgcggttttg gcatcgcgac tctaaacgag
    14401 gacaattata cttgggtatt gtcccgtctg gctgtcgaac tggatgaaat gccttatcag
    14461 tacgaagatt tctccattca gacttgggtg gagaatgtct atcgcctttt tacagaccgt
    14521 aatttcgcta tcatcgataa agagggcaag aagattgggt acgcacgttc cgtttgggcg
    14581 atgattagca tgaatacccg taagccggca gatttgctgg ctcttcatag tggcagcatt
    14641 gtagattatg tttgcgatga accttgcccg atagaaaaac cttcgcggat aaaggtggcc
    14701 tcaaaggaac cggttgctac tttggtagcc aaatacagtg atattgacat taacgggcat
    14761 gtgaacagca tccgttacat cgagcatatc cttgatttgt tcccgataga gatgtataag
    14821 gagaagcgca tccgtcgttt tgagatggca tatgtagccg aaagctatta tggggatgag
    14881 ttgactttgt tcatggatga tgccggtgag ggcgtttacg atgtggaggt gaaaaagaat
    14941 ggcagcgaag tggtctgtcg ctctaaagtg atgtttacag agaaataaat aaatttatca
    15001 acgttggcgt aagccacaaa taaaaattaa aacaaaaaat ggcacaattg aattttggcg
    15061 gtgt
//
