LOCUS       c00077_gnlPro..        14721 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|CEDCOPAD_77.
ACCESSION   c00077_gnlPro..
VERSION     c00077_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 01:48:52
            Original ID  :: gnl|Prokka|CEDCOPAD_77
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14721
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14721
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[77:4721]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      78..4721
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..14721
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14721
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             complement(78..1238)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg77_1"
                     /sec_met_domain="OAD_beta (E-value: 3.1e-153, bitscore:
                     500.2, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGEFINFLGNNLADFWTYTGFANATVGHIVMILIGLFFIYLAVAK
                     EFEPMLLIPIGFGILIGNIPFNMEAGLKVGIYEEGSVLNILYQGVTSGWYPPLIFLGIG
                     AMTDFSALISNPKLMLIGAAAQFGIFGAYMIALAMGFDPMQAGAIGIIGGADGPTAIFL
                     SSKLAPNLMGAIAVSAYSYMALVPVIQPPIMRLLTTKHERLIRMKPPRVVSHTEKVMFP
                     IIGLLLTCFLVPSGLPLLGMLFFGNLLKESGVTRRLAETARGPLIDTITILLGLTVGAS
                     TQASEFLTIDSILIFALGALSFIIATASGVIFVKIFNLVLGKDNKINPLIGNAGVSAVP
                     DSARISQVIGLEYDPTNYLLMHAMGPNVAGVIGSAVAAGILLGFLM"
     CDS             complement(1240..1671)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 64.7; E-value:
                     1.8e-20)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg77_2"
                     /sec_met_domain="Biotin_lipoyl (E-value: 6e-21, bitscore:
                     64.7, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEYKYKINGNIYKVAIGDIEDNIAHVEVNGTPYKVEMEKAPKAV
                     VKPVVRPASTSPAPAPTTVVKPAATSTGKSGVKSPLPGVILDIKVNVGDTVKKGQTIII
                     LEAMKMENNINADKDGKITAINVSKGESVLEGTDLVIIE"
     CDS             complement(1695..2624)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg77_3"
                     /sec_met_domain="OAD_gamma (E-value: 2.4e-15, bitscore:
                     47.5, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKLNIGIFLSLLLMVGLCSCGEQKSNTKLVLNEVLIENESNFQD
                     DYGVHSAWIEIFNRSFGSADLAGCLLKVSSQPGDTATYFIPKGDVLTLIKPRQHALFWA
                     DGEPNRGTFHTNFTLNAATNNWIGLYDSGKKLLDQIIVPAGTLQANQSYARVSDAANEW
                     EVKGSSADKYVTPSTNNKTINSNAKMEKFEEHDSVGIGMSISAMSVVFVGLLLLFIAFK
                     VIGRISVNLSKRNAMKVKGITDKQEAKEKKLGEAPGEVFAAIAMAMHEMQSDVHDVEET
                     VLTITRVKRSYSPWSSKIYTLRETPHKK"
     CDS             complement(2652..4205)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Btheta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg77_4"
                     /sec_met_domain="CT_Btheta (E-value: 8.9e-292, bitscore:
                     958.2, seeds: 72, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNQLEKIKELIERRATARMGGGDKAIAKQHEKGKYTARERIAML
                     LDEGSFEEMDMFVEHRCTNFGMEKKHYPGDGVVTGCGTIEGRLVYIFAQDFTVSAGSLS
                     ETMSLKICKVMDQAMKMGAPCIGINDSGGARIQEGINALAGYAEIFQRNILASGVIPQI
                     SGIFGPCAGGAVYSPALTDFTLMMEGTSYMFLTGPKVVKTVTGEDVSQENLGGASVHST
                     KSGVTHFTAKTEEEGLAMIRKLLSYIPQNNLEEAPYVDCTDPIDRLEDSLNEIIPDSPN
                     KPYDMYEVISAIVDNGEFLEVQPHYAKNIIIGFARFNGQSVGIVANQPKYLAGVLDSNA
                     SRKGARFVRFCDAFNIPLVSLVDVPGFLPGTGQEYNGVILHGAKLLYAYGEATVPKVTI
                     TLRKSYGGSHIVMSCKQLRGDMNYAWPTAEIAVMGGAGAVEVLYAREAKEQENPAAFLA
                     EKEAEYTKLFANPYNAAKYGYIDDVIEPRNTRFRIIRALQQLQTKKLTNPAKKHGNIPL
                     "
     CDS             complement(4308..4721)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Glyoxalase_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg77_5"
                     /sec_met_domain="Glyoxalase_4 (E-value: 1.1e-25, bitscore:
                     80.5, seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKISHIEHLGIAVKSIEEALPYYENVLGLKCYNIETVEDQKVKTA
                     FLKVGDVKIELLEPTSPESTIAKFIEKNNGNGGMHHLAFAVEDGVANALAEAETTGIRL
                     IDKAPRKGAEGLQIAFLHPKSTLGVLTELCEKP"
     CDS             complement(4878..5900)
                     /locus_tag="ctg77_6"
                     /transl_table=11
                     /translation="MWIDKQKTINLQLEMPVRLSTYRKGNAIPPLPGTNIFHSTELFHV
                     FEMTRGYEPLLIVAYIGNRPVGKLLAVIRKSMRLFPPAIIKRCEIYGTGEYFDEEQNKE
                     DLFGEMLEHLTNEVLCKSFLIEFRNLENPLFGYKAFRKNNYFAINWLRVRNSLHSKVPY
                     ERLSMSRKRQINKALRNGAIMEVADNEKDIQDFSRMLKKAYSSQVRKHFPDIGFFRLLA
                     WQNPEKELAKVFLVKYKGKIIGGSICLFSKESAYLWFSGGMRKTYAFLYPGILAVWAPI
                     TYAHEKGYAHLEFMDAGLPFKKHGYRDFILRFGGKQSSTRRWFRFSWKWLNKLLCKFYI
                     "
     CDS             5946..6482
                     /locus_tag="ctg77_7"
                     /transl_table=11
                     /translation="MEQFSDLIKNRRSMRKFTDQELTQEEVVALLKAALMAPSSKRSNC
                     WQFLVVDDKYMLEKLSHCKEMGAAFLADAAMAVVVMADPLASDVWIEDAAIASIMIQLQ
                     AEDLGLGSCWIQVRERFTATGMPSGEYVHTLLDIPLQLQVVSIIAVGHKGMERKPFNED
                     HLQWEKIHINKFGGK"
     CDS             6485..6811
                     /locus_tag="ctg77_8"
                     /transl_table=11
                     /translation="VAAVNHKDTYKASAVFLIVMGMLYLIDKFIGFASHGLPWVMQKDN
                     LLLYAAVIFLWFKADKSVGIVLAGIWLILNISLVIALLGQMSAYLLPAALLLLGVILYL
                     VSTR"
     CDS             6811..7617
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) F420_oxidored"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg77_9"
                     /sec_met_domain="F420_oxidored (E-value: 2.8e-10, bitscore:
                     31.3, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIVLIGAGNVATHLGIALQKAGCLILQVYSRTEESASALADRLL
                     VDYTIVPDEIRRDADLYIVALKDAVLRQLAPVLVKGREQALFVHTAGSMPMDLWKGLVK
                     RYGVLYPMQTFSKQREVDFNTVPFFIEASAPAEVGVLRMVAVRLSPKVYEVTSGQRRHL
                     HLAAVFACNFANHMYALSSHILEKQGISFEVMLPLIDETAGKVHELSPTQAQTGPAVRY
                     DENVISKHLEMLADEESLQELYEKISKSIHDLPLSVIQTNKEGKNS"
     CDS             7623..8141
                     /locus_tag="ctg77_10"
                     /transl_table=11
                     /translation="MINYDLKKIKALVFDVDGVLSAETIYLHPNGEPMRTVNIKDGYAL
                     QLAVKCGLHVAIITGGNTEAVRKRYEGLGIKDVYLAAAVKTREYAHLKEKYGLQDEEIL
                     YMGDDIPDYEVMRLCGLPCCPADAAPEIKETAVYISHRNGGYGCGRDVVEQVLKAQGKW
                     MAHERAFGW"
     CDS             8159..8740
                     /locus_tag="ctg77_11"
                     /transl_table=11
                     /translation="MLENLEKYKIILASNSPRRKELLSGLGIKYEVKTLPGIEETYPDT
                     LKAEEIPLYIACEKAAAYRNIMHPDELIITADTIVWLDGVVMGKPHNEDDARQMLWKLS
                     GKTHQVITGVCLTTARTQRSFSAVTEVTFAELSDEEIDYYIRVYKPMDKAGSYGIQEWI
                     GFIGVCGISGSYFNVMGLPVQCLYTELKKL"
     CDS             8806..9813
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Hacid_dh"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Hacid_dh_C"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg77_12"
                     /sec_met_domain="Hacid_dh (E-value: 5.1e-32, bitscore:
                     100.8, seeds: 88, tool: rule-based-clusters)"
                     /sec_met_domain="Hacid_dh_C (E-value: 5.9e-58, bitscore:
                     185.6, seeds: 144, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAYKIAFYDTKPYDEHSFTEANEKFGFDIRYYKGHLNMNNVVLTK
                     GVDVVCIFVNDTADAEVIRAMADNGVKLLALRCAGYNNVDLAATAGKMKVVRVPAYSPY
                     AVAEFTVALMLSLNRKIPRATMRTRDGNFSLHGLMGFDMHGKTAGIIGTGKIAKILIQI
                     LRGFGMNVLAYDLYPDYNFAREHQVVYCTLDELYHSSDIISLHCPLTEQTKYLINDYSI
                     SKMKDGVMIINTGRGQLIHTNALIEGLKTKKVGYAGLDVYEEEEPYFYEDKSDKIIDDD
                     TLARLLSFNNVIVTSHQAFFTKEAMTNIAHTTLQNVKDFVEGRPLVNEVAVGRV"
     CDS             complement(9810..10979)
                     /locus_tag="ctg77_13"
                     /transl_table=11
                     /translation="MQTIKLYIKDWLAIHPYIQQQTTDRYFVDLANRLYSTCTIREIPE
                     SIKKKLCLYTAAYFEDVISGLGLWQAFIKKHLELYDTSLPFYTIRPDYIKDEINEEDIR
                     FIIWNTLEKAPYKHLYINPMDRNIEETAHLFFRILDEEYETAPANATLQEFFMDFKGKE
                     DANHKLRWLFGHTYLTEPSVQEYIAQVTETDKFIIPCGPLALFLHEWIDLLTNGETECW
                     EEIEGLYPAIPEISDEMKERNHHTYQLFTQGTNGARIVYLKSYKELHSFLTQVLQWPDD
                     SNHTLPQMKEHKDFIMMVNSEKGILLAKDICKYISDPLNPMYDAATAAQEAFSLLTIPT
                     KCPPDLMEYLINNHYIPDAQFPEFGEKELVQKNADFIARHSLLYYYRGD"
     CDS             11098..11487
                     /locus_tag="ctg77_14"
                     /transl_table=11
                     /translation="MEIDLTTPALLFSAISLIMLAYTNRFLSYAQLVRTLKDQYRENHS
                     AVTAAQISNLRKRLYLTRAMQVTGIGSLLLCVVSMFLMYIQLYLISVYIFGLALVLLII
                     SLGISVREIYISVKALELHLSDMDS"
     CDS             complement(11489..12664)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MFS_1"
                     /gene_functions="transport (smcogs) SMCOG1058:Major
                     facilitator family (Score: 92.5; E-value: 8.1e-29)"
                     /gene_kind="transport"
                     /locus_tag="ctg77_15"
                     /sec_met_domain="MFS_1 (E-value: 2.8e-29, bitscore: 92.5,
                     seeds: 192, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKQELKENQGLPASLLWTLAIIAGISVANLYYNQPLLNRISRDLQ
                     TSEFTANLIAMITQIGYAIGLLFIIPLGDLFKRKTIILINFTVLVVSLLTIALTPYIHL
                     ILFASLLTGICSVMPQIFIPIAAQFSTPKTKGRNVGMIVSGLLTGILASRVVSGIVGEY
                     LGWRFIFFVAAGMMVICLIIIMRVLPDMPCNFKGKYSDLMKSLFSLVIEYPQLRISSLR
                     AGIAFGSFLALWTSLAFKMGQAPFFAGNNIVGLLGLCGIAGALTASYIGKYVHVLGVKR
                     LNYIGCGLIFVAWFSLYFGQDSYVGIITGIFIIDIGMQCIQLSNQTTIFALNPKAANRI
                     NTIFMTTYFIGGSVGTFLAGTFWHWFGWQGVVGTGIALTACSFMINIFAKR"
     CDS             12730..13245
                     /locus_tag="ctg77_16"
                     /transl_table=11
                     /translation="MKNCIKTVCFLFWTCVMFIACIDDDVEEGTVDLQTGENIPVFSVV
                     MDDGQIITSETLKGEVSLIVFFHTGCPDCRKELPVLQKIYTDYGQRIRMVCISREESSA
                     EIVRYWDENHLTLPYSAQENRTVYYQFAKSGIPRVYVIDKELVIRSVFTDNPLASYEDL
                     AEAIETCL"
     CDS             13344..13955
                     /locus_tag="ctg77_17"
                     /transl_table=11
                     /translation="MQILKDNIRSRILDVAKQQFELKGYSKTSMREIAVDVGVGVGNIY
                     NYFKSKDELFHEVVRPVLYALEMLLQEHHGIQGEDIMMMRSEEYLETCINEYISLYDTH
                     HRLMKILLFRAQGSSLERFRENYTDRSTELVKVWFTVMQRKYPMINIAIPDFIIHLHTV
                     WMFTMFEELLRHSIAKQEMKAILHNYILFEIQGWRAIIRI"
ORIGIN
        1 tttcttaatc tatatcaata aaaaatcctc ttccacatat tagttgaaga ggattttatt
       61 tgttgttgtt caatgaatta catcaagaat ccaagtaaaa taccggctgc tacggcagaa
      121 ccgattacac cagctacgtt gggacccata gcatgcatca gcaagtagtt ggtaggatca
      181 tattccagac caataacctg agagatacgt gccgagtcgg gaacagcaga tacaccggca
      241 ttaccgataa gcgggttgat tttgttatcc ttacctaata ccaagttgaa tatcttcacg
      301 aagataactc cagaagcagt agcaatgatg aatgacaatg cacccagcgc gaaaatcaag
      361 atcgaatcaa tggtaaggaa ctctgaagct tgcgtggaag cacctactgt caatcctaat
      421 aagatggtaa tggtatcaat cagcggaccg cgggcagttt ctgctaagcg acgagttaca
      481 ccgctttctt tcaataagtt accaaagaaa agcataccca atagaggcag acccgacgga
      541 accagaaaac aagtaagtaa caaaccaatg atagggaaca ttactttttc tgtatgagaa
      601 acgacgcgtg gtggtttcat acggatcaaa cgttcgtgct tggtagtgag cagacgcatg
      661 ataggcggct ggataaccgg taccaatgcc atgtatgaat aggctgatac cgcaatagct
      721 cccatcaggt taggcgccag tttggatgaa aggaagattg ctgtcggacc gtccgcacca
      781 ccgatgatgc cgatagcacc agcctgcatc ggatcaaagc ccattgccaa tgcaatcatg
      841 tatgcaccga aaataccaaa ctgtgcggca gcaccaatca acatcagttt aggatttgaa
      901 atcaatgccg agaaatccgt cattgcaccg atacctaaaa agataagtgg tggataccat
      961 ccggaggtaa ctccttgata taaaatatta agaacagaac cttcctcata gatgccgact
     1021 ttcagtccag cttccatgtt gaaaggaata ttaccgatca agataccaaa accgatagga
     1081 atgagcaaca tcggctcaaa ttccttggcc acggcaaggt atatgaagaa taaacctatc
     1141 aggatcatta cgatatgacc aacagtagca ttggcaaaac ccgtatatgt ccaaaagtca
     1201 gctaggttat tccctaaaaa gttgataaat tctcccatat tattcaataa ttacaaggtc
     1261 agtaccttcg agaacggatt ctcctttact tacattgatt gcggtgatct tgccgtcttt
     1321 gtctgcgttg atgttattct ccatcttcat agcttcaagg ataatgatgg tttgcccctt
     1381 ttttacggta tcaccaacat ttaccttaat atcaaggatt acacctggca acggagattt
     1441 aacgcccgat tttcctgtag aagttgcagc aggctttact actgtagttg gagccggagc
     1501 agggctggtt gatgcaggac gaactaccgg tttcactaca gctttcgggg ctttttccat
     1561 ttctactttg taaggagtgc cgtttacttc aacatgagcg atattatctt ctatatctcc
     1621 aatggcaacc ttatatatgt taccgttaat cttatattta tattctttca tcgttttatc
     1681 tttttattgg tgacttactt tttgtgggga gtttcacgca aggtataaat cttagaactc
     1741 cacggtgaat agctacgttt tacacgagta atggtaagaa cagtttcttc tacatcgtgt
     1801 acatcgcttt gcatttcgtg catagccatg gcaattgcgg cgaatacttc gcctggagct
     1861 tcacccagtt tcttttcttt ggcttcttgt ttgtcggtaa taccttttac cttcatggca
     1921 ttgcgcttgc tcaggttgac agaaatacgg cctataactt tgaaagcaat aaacagaagg
     1981 agcaagccta cgaatacgac actcatagct gatatggaca taccaatacc cacactgtca
     2041 tgttcttcaa acttttccat cttagcgttg ctgttgatag tcttgttgtt agtgctagga
     2101 gttacatact tgtctgcact agaacctttt acttcccatt catttgcagc gtcgctgaca
     2161 cgtgcgtatg attggtttgc ctgtaatgta cctgcaggaa ctataatctg atccaataat
     2221 ttcttgcctg aatcatacaa gccgatccaa ttgttcgttg cggcattcag ggtgaagttg
     2281 gtgtggaaag taccacggtt aggttcacca tctgcccaga acaaagcgtg ctggcgaggt
     2341 ttgatcaaag tcaatacatc acctttaggg ataaaataag tagcagtatc tccaggctgg
     2401 ctgctcacct tcagtaaaca accggcaagg tctgcgctac caaatgatct attgaatatt
     2461 tcaatccatg cgctgtgtac tccgtagtca tcttggaaat tgctttcatt ttcaatcagc
     2521 acttcattca gtaccagctt ggtgtttgat ttctgttctc cacaagaaca taaacccacc
     2581 atcagcagca aagaaaggaa tattcctata tttaatttct tcatgttcaa ttctcaattt
     2641 ttaattttta attaaagagg aatattacca tgcttcttag ccggattggt taatttctta
     2701 gtttgcaact gttgcaatgc acggatgatg cggaaacggg tattacgcgg ttcaatcaca
     2761 tcatcaatat agccatattt ggcagcattg taaggattgg cgaacagctt ggtgtattca
     2821 gcttcttttt cggctaggaa tgcggcagga ttttcctgtt ctttggcttc gcgggcgtat
     2881 aatacttcta ctgcacctgc accacccata acggcgattt cggcagtagg ccatgcataa
     2941 ttcatatcac cgcgaagttg tttacagctc attacaatgt gagatccgcc gtatgattta
     3001 cgcagggtaa ttgttacttt gggtacagtc gcttcgccgt aagcatacag caacttggcg
     3061 ccgtggagga ttacgccgtt gtattcttgt cctgtgcctg gaaggaatcc cggaacatct
     3121 accaatgaaa caagaggtat attgaaagcg tcgcagaaac gtacaaaacg cgcaccttta
     3181 cgtgacgcat tgctgtcaag tacacccgcc aggtattttg gctggtttgc aacaatacct
     3241 acagattgtc cgttgaaacg tgcgaaacca atgatgatat ttttagcgta gtgaggttgg
     3301 acttccaaaa actcaccatt atctacgatg gcgctgatca cctcatacat atcgtatggt
     3361 ttgttggggc tgtcggggat aatttcgttc aaagagtctt ccagacggtc gataggatcg
     3421 gtacagtcta catagggagc ttcttccaga ttattttgag gaatatagct taacaatttg
     3481 cggatcatgg ctaacccttc ttcttccgtc ttggcagtaa aatgagtaac accggatttg
     3541 gtagaatgaa cgcttgcacc acctaagttt tcttggctta catcttcacc tgtaacagtc
     3601 tttaccactt tcggtccggt aaggaacatg tatgatgtgc cttccatcat caatgtgaag
     3661 tctgtcagcg caggagagta aacagctccg cctgcacaag gaccgaaaat acctgaaatc
     3721 tgtggaataa cacctgaagc aagaatattg cgttggaaaa tttcagcata accggccagc
     3781 gcattgatac cttcttgaat acgtgcgcca cccgagtcat tgataccgat acagggagca
     3841 cccattttca tggcttgatc cattactttg cagattttca gagacattgt ttctgacaga
     3901 gaaccggcag aaacagtgaa atcctgtgca aagatgtaaa ctaaacgtcc ttctatggta
     3961 ccacaacctg ttactacacc gtcgcccgga taatgttttt tctccatgcc aaaattggtg
     4021 catctgtgtt ccacaaacat atccatttct tcgaaactgc cttcatccag caacatggct
     4081 atgcgttcgc gggctgtata ttttcctttt tcatgctgtt ttgcaattgc tttatcacct
     4141 ccacccatgc gtgctgtagc ccggcgttcg ataagctctt ttattttttc aagttgattg
     4201 ctcattttac ttatgatttt acaatttacg attaaaaaat atttctattt acgcttgaac
     4261 cagactaaat acactgattt caattgtgaa tagtcagatc tcgtgtttta tggtttttcg
     4321 caaagctcag tcaggacacc caaagttgat ttgggatgta aaaaagcaat ttgcaaacct
     4381 tcagcacctt tacgcggagc tttgtcaatg agacggatgc cagtggtttc cgcttcggct
     4441 aacgcatttg ccacaccatc ttccactgca aaagccaaat gatgcatacc accgttgcca
     4501 ttattttttt caatgaactt tgcgatagtg ctttcggggc ttgtaggttc cagcagttct
     4561 attttaacat cacctacttt cagaaaagcg gttttaactt tctgatcctc tactgtttcg
     4621 atattgtagc atttcagacc taatacgttt tcataatacg gcagggcctc ttcaatgctc
     4681 tttacggcaa tgcccaggtg ttcaatgtgt gagattttca tgatcttata attttaatag
     4741 tttggtttta tactcaagtt ttcagataaa actgcacaaa gaaagtaatt tcgagttaaa
     4801 taaagaaata tttcttcaat tttatttctt atttgcgaga tgcttcacaa cactttagac
     4861 aaaaagacaa aaatgaatta aatatagaat ttgcacaaga gtttgttcag ccacttccaa
     4921 ctgaagcgga accagcggcg tgtactgctc tgcttgccgc caaagcggag tataaagtcc
     4981 ctgtaaccgt gctttttgaa cggtaatcct gcatccatga attccaaatg tgcatatcct
     5041 ttttcgtgag cataggtaat aggtgcccat acggctagaa taccggggta aagaaaagca
     5101 taggttttcc gcatacctcc tgagaaccac agataagcac tttcttttga gaaaagacag
     5161 atagaaccac ctatgatttt gcctttatat ttcacaagaa acactttggc taattctttt
     5221 tctgggtttt gccatgctaa tagccggaaa aagccgatgt ccgggaaatg ttttcttacc
     5281 tgtgaggaat aggctttttt caacattcgt gagaaatctt gaatatcttt ctcattgtcg
     5341 gctacttcca tgatggcacc gtttctcaac gctttgttta tttgtctttt gcgagacatg
     5401 ctcagccgtt cgtaagggac tttactgtgc agtgagttac gtactcttag ccaattaatg
     5461 gcgaaatagt tgttctttct gaaagctttg tatccgaata gcggattttc caagttgcgg
     5521 aactcgatga ggaacgattt gcataatact tcgttggtga gatgttccaa catttccccg
     5581 aacaggtctt ccttattctg ttcttcatca aaatactcgc ctgtgccata aatctcgcat
     5641 cgtttgatga ttgcgggggg gaacaagcgc atactcttcc ggatgacagc cagcagtttg
     5701 cctacaggac ggtttcctat ataggctacg ataagcagag gttcgtatcc ccgagtcatt
     5761 tcaaagacat gaaataactc ggtagaatgg aaaatgtttg ttccaggcag agggggaatg
     5821 gcatttcctt tgcgatatgt acttaatctg acaggcatct ctaattgcaa atttattgtt
     5881 ttttgtttat caatccacat tctagttgta tatttgtgca gaaaaataaa ttaactgagt
     5941 atattatgga acaatttagt gacttaataa agaacagacg cagtatgcgt aagttcacgg
     6001 atcaagagtt gacacaggaa gaggtggttg ctttgttgaa ggctgctttg atggctccgt
     6061 cttctaaacg tagcaattgc tggcagtttc ttgtggtaga tgataagtat atgctggaaa
     6121 aactttccca ttgtaaggag atgggggcag cttttctagc ggatgctgct atggctgtag
     6181 ttgtgatggc tgatccgttg gctagtgatg tttggattga agatgcggca attgcttcca
     6241 taatgatcca gttgcaggca gaagatttgg ggttgggaag ttgttggata caggtgcgtg
     6301 aacgttttac cgctaccggg atgccctcgg gtgaatacgt gcatacactg cttgatattc
     6361 cgttgcagtt gcaggtggtt tccattatag cggtaggaca taagggcatg gaacgcaagc
     6421 cttttaatga ggaccatttg caatgggaga aaattcacat caataaattt ggaggcaagt
     6481 aaacgtggct gctgtcaatc ataaggatac gtataaagct tctgcggtgt ttctcattgt
     6541 gatgggtatg ctttatctga tcgataagtt tataggattt gcctcacacg ggttgccatg
     6601 ggttatgcag aaagacaatc tgttactgta tgcagctgtt attttccttt ggttcaaggc
     6661 cgataagtca gtaggaattg tattggcggg tatatggctg atattgaata tcagtttggt
     6721 gatagctttg ttggggcaga tgtctgctta tttgttgccg gcggctttgt tgttgttagg
     6781 agttatttta tatttagttt cgacccgatg atgaaaatag ttctgatagg agctggcaat
     6841 gtggctaccc atttgggaat cgctttacaa aaggcagggt gtcttatttt gcaggtatac
     6901 agccgtacag aggagtctgc ttctgcattg gctgacagac ttttagtaga ctacacaatt
     6961 gtgccggatg agatacgtcg ggatgccgat ttgtatattg tagcgctgaa agatgcagtt
     7021 ttgcgacaat tggctcctgt attggtgaaa ggaagggagc aggctttgtt tgtacatacg
     7081 gcgggtagta tgcctatgga tttatggaag gggttggtaa aacgctatgg ggtactttat
     7141 cctatgcaga cttttagcaa gcagcgtgaa gttgatttca ataccgtacc tttttttata
     7201 gaagcatctg ctccggcaga agtgggagtg ctgcgtatgg tggcagttcg tctcagtcct
     7261 aaagtgtatg aagtgacttc cggtcaacgt aggcatttgc acctggcggc agtctttgct
     7321 tgtaattttg ctaaccatat gtatgcatta agttcacata tactggaaaa gcaggggatt
     7381 tcttttgaag tgatgcttcc gctgatagac gaaactgccg gcaaagtaca tgaactttct
     7441 cccacacagg cgcagacagg tccggctgta cgctacgatg aaaacgtaat aagcaaacat
     7501 ttggagatgt tggcggatga ggagtctttg caggaattgt acgaaaagat aagtaaaagt
     7561 attcatgatc tccctttgtc tgttattcag acaaataaag agggaaagaa ctcataagtg
     7621 gtatgataaa ctatgattta aagaaaataa aggcattggt atttgatgtc gatggggtat
     7681 tgagtgcgga aactatttat ttgcacccca atggtgaacc catgcgtacg gttaatatca
     7741 aggatgggta tgcattacag ttggctgtga aatgcgggct gcatgttgcc atcattactg
     7801 gtggaaatac cgaggcggtg cgtaagcgtt atgaggggct gggtatcaag gatgtttatc
     7861 tggctgctgc ggtaaagacc cgggagtatg cccatttgaa ggaaaaatat ggattgcagg
     7921 atgaggagat actctatatg ggcgatgata ttcccgatta tgaagtgatg cgtttgtgtg
     7981 ggctaccttg ttgtcctgct gatgcggcac ctgagataaa agaaacagct gtttatattt
     8041 ctcatcgtaa tgggggctat ggatgtggcc gtgacgtggt ggaacaggtt ttgaaggctc
     8101 aaggaaaatg gatggctcat gaaagagcct tcgggtggta atgaaataaa gaaaagctat
     8161 gttggaaaat ttagaaaaat ataaaataat ccttgcttcc aattctccgc gccgcaaaga
     8221 attgttatcc ggcttaggta taaaatatga ggtaaaaaca ctacccggca tagaggaaac
     8281 ctatccggat acattgaaag cagaggaaat tcctttgtat atagcttgcg agaaggcggc
     8341 tgcttaccgg aatatcatgc atccggacga attgattatt actgctgata ccattgtatg
     8401 gttggacggt gtagtcatgg gcaagcctca taacgaggat gatgcacggc agatgttgtg
     8461 gaagctttct ggcaagaccc atcaggtgat aactggggtt tgtctgacta ctgccaggac
     8521 tcagagaagt ttttctgctg tgacagaagt aacgtttgca gaattgtccg atgaggagat
     8581 cgattattat attcgggttt acaagccgat ggataaggct ggttcttatg gtatacaaga
     8641 gtggataggc ttcattggtg tctgtggaat ttcgggtagt tacttcaatg tgatgggact
     8701 ccctgtgcag tgcctgtaca cagaactgaa aaaactataa gtctgtatgt gaacagtaag
     8761 ggacgtgttt ttgttattta tatgaactat aaataaaaaa taattatggc ttataaaata
     8821 gctttttacg acacgaaacc ctacgacgaa cactcgttta cggaggctaa tgagaagttt
     8881 ggctttgata tcaggtatta caaaggccat ttgaatatga ataacgtggt gttgaccaaa
     8941 ggagtggatg tggtttgcat cttcgtaaac gatacggctg atgccgaagt tatccgggca
     9001 atggcggata atggtgttaa actgctggct ttaagatgtg ctggttataa taatgtggat
     9061 ttagcggcaa cggcaggtaa gatgaaagtg gtacgggtac cggcatattc gccatatgct
     9121 gttgccgaat ttacagtggc attgatgttg tcactcaatc gtaagattcc tcgtgccaca
     9181 atgcgcacac gtgacggaaa cttttctttg catggactta tgggatttga tatgcatggc
     9241 aagactgccg gaattatcgg tacgggtaag attgccaaga ttttaattca gatattacgt
     9301 ggatttggta tgaatgttct tgcatatgat ctttatcccg attacaattt tgcccgtgaa
     9361 catcaggtgg tttattgtac tttggatgaa ctttatcata gttcggatat catctccctg
     9421 cattgtcctt tgacagaaca gacaaagtat ctgattaatg attattccat cagtaaaatg
     9481 aaagatgggg tgatgattat caatacgggg cgtgggcagt tgattcacac caatgccttg
     9541 atagaggggc tgaagaccaa aaaagtggga tatgccggtc tggatgtata cgaggaagaa
     9601 gagccttatt tttatgaaga taagtctgat aagattattg atgatgacac tttagctcgt
     9661 cttctgtctt tcaataatgt gattgtaact tcacatcagg ctttttttac caaagaggca
     9721 atgacgaata ttgctcatac tactctacaa aacgtgaaag actttgttga aggtagacct
     9781 ttggtgaacg aagtagcggt ggggagggtc taatctcccc tgtagtaata caataaggaa
     9841 tggcgggcta taaagtccgc attcttttga accagttcct tttcaccaaa ttcggggaat
     9901 tgtgcatcgg ggatatagtg gttgtttatt aaatattcca tcaggtccgg cggacatttg
     9961 gtcgggatag taagcaggct gaatgcctct tgggcagccg ttgcggcatc atacatcggg
    10021 ttaagaggat cactgatgta tttgcatata tccttcgcca atagaatacc tttttcggaa
    10081 tttaccatca tgatgaaatc cttatgttcc ttcatttggg gcaaagtgtg attggaatcg
    10141 tccggccatt gtaatacttg ggtaaggaaa ctgtgtagtt ctttatagct tttcagatat
    10201 acgatacggg caccatttgt gccttgcgtg aacaattgat aggtatggtg gttcctttcc
    10261 ttcatctcgt ccgatatttc gggaatggca gggtatagtc cttctatctc ttcccaacat
    10321 tcggtttctc cgttggtcag caggtcaatc cattcatgaa gaaacagggc aagggggcca
    10381 catggaatga tgaatttgtc ggtttctgta acctgtgcaa tatattcttg tacagatggt
    10441 tctgtgagat aagtatgtcc gaacagccag cgtagtttat ggtttgcgtc ctcttttcct
    10501 ttgaaatcca taaagaactc ctgtaacgtg gcattggcgg gagccgtttc atattcttca
    10561 tccaatatcc ggaaaaataa atgtgcagtt tcttcgatat tcctgtccat cggattgata
    10621 tacagatgtt tatatggagc cttctctaaa gtgttccaaa tgatgaaacg gatatcttcc
    10681 tcattgatct catcttttat ataatccggt cggatggtat agaaaggaag tgacgtatca
    10741 tatagttcca gatgcttttt gatgaatgct tgccatagac ctaaacctga aatgacatct
    10801 tcaaaatagg cagcggtgta aagacataac ttctttttaa tggattcggg aatctctctt
    10861 atcgtacaag tggagtataa tcggttagcc agatcgacaa aatatctgtc tgtagtctgt
    10921 tgttggatat aaggatggat agccaaccag tcttttatgt ataattttat ggtttgcata
    10981 ttagtttatt ggaattattt ttattgcaaa gatattcctt tcattgtaaa aaggaaggag
    11041 aatatcggga tatttacttt atctttgcaa tattctaact ttgaaatacc tataaaaatg
    11101 gaaatagatt taacaactcc tgctttattg ttctcagcca tatcgctgat tatgctggca
    11161 tataccaatc gttttctgtc atatgcccag ttagtacgca cgttgaagga tcagtatcgt
    11221 gaaaatcatt cggcggttac ggcagcacag atttctaatc tccgcaaacg cctttatctg
    11281 acacgtgcta tgcaggtgac aggtatcggg agcttgttgc tttgcgtggt cagtatgttt
    11341 ttaatgtata tacagcttta cctcatatcc gtatatattt ttggactggc actggtgctg
    11401 ctcattattt ctttaggcat ttctgtccgc gagatttata tttccgtcaa ggcgctggaa
    11461 ctgcatctga gtgatatgga ttcttgattt atctttttgc aaagatattt atcataaagg
    11521 aacaggctgt taatgcgatc cctgttccta ctactccttg ccatccaaac caatgccaga
    11581 atgttccggc aaggaatgta cctacggaac cacctataaa ataagttgtc ataaaaatgg
    11641 tattaatacg gttggctgct ttcgggttga gggcgaaaat cgtagtctga ttactcaatt
    11701 ggatacattg catacctata tctataataa aaattccggt gatgataccc acgtaagagt
    11761 cctgaccgaa ataaagtgag aaccacgcca caaaaatcaa gccacaacct atgtaattca
    11821 gtcgtttgac tcccaaaaca tgtacatatt ttcctatata cgaggcggtg agagctcctg
    11881 ctatgccgca caatcctaat aaccctacaa tattgtttcc tgcaaagaaa ggagcttgtc
    11941 ccattttgaa tgccagcgaa gtccacagag ctaggaatga accgaaagca attccggcac
    12001 gtaaggaaga aatacgtaac tgggggtatt ctatcactaa tgaaaacaag gatttcatca
    12061 gatcactata tttcccttta aaattacatg gcatatcggg tagtacacgc atgataatga
    12121 tgagacatat caccatcatt cccgccgcta caaagaaaat aaaccgccat cccaaatatt
    12181 cgccgacgat tccgctgact acgcgcgaag ccaaaatacc agtcagtaac cctgatacaa
    12241 tcatgcctac atttcttcct ttggttttgg gggtggagaa ttgtgcagct atggggataa
    12301 agatttgtgg catcaccgaa caaatgccgg tcagcagaga ggcaaataaa atgagatgga
    12361 tataaggagt cagtgcgatg gttagtaatg aaacgactag gactgtgaaa ttgattagaa
    12421 taatggtttt ccttttaaat aaatctccca aaggaataat gaacagcaat ccgatggcat
    12481 aacctatttg ggtaatcatt gctatcaggt tggcggtgaa ttcggatgtt tggagatcac
    12541 ggctgatgcg atttaataaa ggttggttat aatataaatt ggcaacggag attcccgcaa
    12601 taattgctag cgtccaaagt aaggaggcag gtagtccttg gttttctttt aattcttgtt
    12661 tcatgctgca aaagtagtaa tttcatgaaa atcatgttat ctttgtaaag aagaaaaata
    12721 gaaatgaaaa tgaagaattg tataaaaacg gtctgttttc tgttttggac ctgtgtaatg
    12781 tttatagcgt gtattgatga tgatgtggag gaaggtactg ttgatttaca aacaggagag
    12841 aacattcctg ttttttctgt ggtaatggat gatggacaaa taataacttc cgaaaccctg
    12901 aaaggagagg tttccttgat tgtgtttttt catacgggtt gtccggactg ccggaaagaa
    12961 cttcctgtgc tgcaaaaaat atatacggat tacggtcaaa gaatccggat ggtttgtatt
    13021 agcagggaag agagttcggc agagattgtc cgttattggg acgaaaatca tttgactttg
    13081 ccctattcgg cccaagaaaa ccgcacggta tactatcagt ttgctaaatc ggggatacct
    13141 cgtgtttatg tcatagataa agagttggtt atccgtagtg ttttcacgga taacccgttg
    13201 gcaagttatg aagatttggc tgaggctata gaaacctgtt tgtagttttt agagagggta
    13261 aaatccctaa aaataggtat tgtcagataa tgataagctc attacctttg ccatcataaa
    13321 aacagaatca caactgacta tacatgcaaa tattaaagga taacatacgt agccgtattt
    13381 tggatgtagc caaacaacaa tttgagttga aaggttattc caagacttcc atgcgtgaga
    13441 tagctgtgga tgtaggtgtt ggggtgggaa atatttacaa ctactttaaa agtaaggatg
    13501 agctgtttca tgaagttgtt cgtccggttt tgtatgcgtt ggaaatgctg ttgcaggaac
    13561 atcatggaat acagggcgag gatattatga tgatgaggtc ggaagaatac ttagaaacct
    13621 gtataaacga atatatttcc ttgtatgaca cccaccacag attgatgaaa atactgttat
    13681 ttcgtgcgca aggttcttca ttggaacgtt ttcgggagaa ttatacagac cgttcaaccg
    13741 aattagtcaa agtctggttt acggtgatgc agagaaagta cccgatgata aatatagcta
    13801 ttcccgattt tataatccat ttgcatactg tatggatgtt tactatgttt gaggagcttt
    13861 tgaggcattc aatagcgaaa caggaaatga aagctatttt acacaattat attctatttg
    13921 agatccaagg ttggagggcc attattcgaa tatgacaggt aaaatttgta tatacagact
    13981 ggttgctaca gtaaggcagc aggaaaggag gaagtcttta cggaggtttc ctcctttttt
    14041 tatgaacaaa tttgaatacc gttcactaat aatccgtttg atatagtaca attatatgaa
    14101 aaagaagaaa gaaggattgt cccgtttgtt agagattgcg ggacagaaga aagggttgct
    14161 tctgctggca ggtttgttgt cggtaggtag tgccatgtgt atgcttgtgc cctattgggc
    14221 tgtctatgag gtgctgaaag agttgttgtt gcatggcagc aatcctgttt tggcaaatgg
    14281 aactgaaatg atacgttggg gatggatcgc actgggtgga cttgtcggcg gattggtttt
    14341 gctgtacgct gcccttatgt cctctcatgt agccgcattc cgaatcttgt atgggttgcg
    14401 tgtccgttta tccgaacata tcggtaaact tccgttgggc tatctgaaca acacttccat
    14461 cgggtccatc aaaaaaacga tggatcagaa tatcgagaag atagagggat tcattgcaca
    14521 tactatcccc gatttggtaa atgtgatagc tacggtggca gtgatgtttg tcattttctt
    14581 ctcattaaat gtatggttga cagtggcgtg tttgacagtt gtcgtattaa gccttttcct
    14641 gcaattttcc aattttatgg gaaagaaagc gaaggagttt atgcgtgtct attacgatgc
    14701 acaggaaagg atgagtactt c
//
