LOCUS       gnlProkkaFGJFBCEM_4    14096 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|FGJFBCEM_4.
ACCESSION   gnlProkkaFGJFBCEM_4
VERSION     gnlProkkaFGJFBCEM_4
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 20:47:28
            Original ID  :: gnl|Prokka|FGJFBCEM_4
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 161538
            Orig. end    :: 175634
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14096
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[10000:10267]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10267
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..14096
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..14096
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             718..1566
                     /locus_tag="ctg4_111"
                     /transl_table=11
                     /translation="MNISEFNINAEFIACNHITTNELNPLVEKPYHTKASIFALCTKGV
                     LKTIINHTQFRVEANALLVIPPETFVQLLHTSEDAEIYVAMFSQQLIQSAGAGKLMMDK
                     FHIIGKHYIFPLSKTDFQLYAEFMTYLSHLYQRTESPSSLVSLQTLLTYLLQGISELCP
                     ERPRIKETPGSRHFNQYRIFIRLVHTDYVREHQVSYYALKMNMRPAALCRLVKKESGHT
                     AMEIINNTIIMDAKAQLCTANTPIKDIAVSLGFNNAAFFNKFFKRHTGIPPQKFRTSSK
                     Q"
     CDS             complement(1641..2417)
                     /NRPS_PKS="Domain: oMT (51-145). E-value: 6.6e-11. Score:
                     32.7. Matches aSDomain: nrpspksdomains_ctg4_112_oMT.1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089:methyltransferase (Score: 81.3; E-value:
                     1.3e-24)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg4_112"
                     /transl_table=11
                     /translation="MSNENKTIHDFEFNLICDFFSNMERQGPGSPEVTLKALSFVDGLT
                     DESLIADIGCGTGGQTMVLAGHVPGQITGIDLFPGFIDIFNRNARQLGLQDRVKGIAGS
                     MDALPFGEEELDMIWCEGAIYNIGFERGLKEWRKYLKPGGYIAVSESSWFTDERPAEIN
                     DFWMDAYSEMDTLPNLVAKLYKAGYLPVATFILPENCWTEHYFASKVAAQEIFRKKYAG
                     NKIAEEFSSLQMIEDELYGKYKEFYGYVFFIAKKVG"
     aSDomain        complement(1983..2264)
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg4_112_oMT.1"
                     /domain_subtypes="oMT"
                     /evalue="6.60E-11"
                     /label="ctg4_112_oMT.1"
                     /locus_tag="ctg4_112"
                     /protein_end="145"
                     /protein_start="51"
                     /score="32.7"
                     /tool="antismash"
                     /translation="DIGCGTGGQTMVLAGHVPGQITGIDLFPGFIDIFNRNARQLGLQD
                     RVKGIAGSMDALPFGEEELDMIWCEGAIYNIGFERGLKEWRKYLKPGGY"
     CDS             complement(2651..2983)
                     /locus_tag="ctg4_113"
                     /transl_table=11
                     /translation="MKQLIACCGLDCENCAARIATVNNDDELREKTAKEWSVLNNTPEI
                     TPETIHCMGCRADGVKFAYCSDYCAIRKCVYEKGFNTCGDCKELDTCQVVGAVLQHAPG
                     ARGNLY"
     CDS             3834..4175
                     /locus_tag="ctg4_114"
                     /transl_table=11
                     /translation="MESLIMKNCYGIDFRSWRKELRTREKTKQPPCKLPDRASRSLQGV
                     LFKVYQISVLILLKKILFSFFSVCLPLFIRHIAAMLLRKTSSKTMQTVTKYLKELSGVR
                     SDNSPNSYK"
     CDS             4541..4756
                     /locus_tag="ctg4_115"
                     /transl_table=11
                     /translation="MKQNTPDGREAYITPSIEVIKMENEGVIATSGEPYHPITRSYSGS
                     TSTHSYNSASSSDLEDLINDILTVEN"
     CDS             4770..8348
                     /locus_tag="ctg4_116"
                     /transl_table=11
                     /translation="MMKLRNLMQVACMATAALTAFSCSQEEFENSGRKGNITVNATFEG
                     AGTDTRTTVNDEYKILWQDTDALGLFCSNAESNYSNTKLEYASGAGQTSATFNGSKPSG
                     ETAVFSIYPYQQNMSVSGNTLTMTLPATLTNYNGSSNGPMYAKVTNPDNLSALSFKHMA
                     AMIKLTVNKIPAEATTFKIIASNNIAGTCTVDLTAADPILAVTSDESKEITASFTASAD
                     IKSRNFYIPLPTGTYSSITAQLTNGSDKVYFTKTLNDKILGRRDILVVPPLDCVVVEAT
                     TPSALSTALADSKNLPQEAPTAATVTDIAVSGSFNTTSGSNDGIAIPVLQNSDINLAFN
                     TAPTTSTSAPLKLTDKTNTSVSTPAATATNSVSLAVPETTAEQEAPSVAITMPSTTVTL
                     AAVGNKATYNEVTATTAQQTLIINAGVTVKKLTVKGGNLKIYGKVEQLVHDAGNTTIYI
                     IKGTEASLPATIDSKFVVQSDVAVLKTAFANGEDFKLSADADITGQSVSVPAGKSVVLD
                     LNGYTLTADNSATGKIIVLGKMTLKDSSTEKKGKIVASQDYTAASYNGSLIEIAGEDAS
                     MTMESGNISAVRKTPNSNGQYGVGVTDGGDFTMTGGKIEAGWFAVAGNGNYKTQNSIIN
                     ITDGELISTADYAVYLPQSGTTTISGGKVYGAAGGVCIQRGTLNVEGTALITSKGTGST
                     GNWGDGTGGLDCAAINVSGAYGIATVNIKGGTLIAEAKSLITEGTTYTPVINVTGGTFS
                     DPSALKYMKTNANVNIKLTADKTCPGFKTTSGQTLTMDLGGKILTLADPTVGSTGTETN
                     SCQLLEGSNVTFKNGTLKSDNNKIMIQNYCNLTLDNMTVEDTNAQYVVSNNCGNISINN
                     TTINAGSNANQFAFDVCGYAKYTAGVTVTVSGTSVINGKVEISKSAGNTEPMKLNITGG
                     TFNGDLKVDASVGTENAKSIISVSGGTFSDPSVLKYMATNATVDIKLLSNINIAKTELA
                     TGYILNAANATANLNLNGHDIINSSETADATPFTQIFTVQNGTLNISGNGNVKCDASAT
                     AKDDGYRMVIEARGHGTVNIHGGSYYNTQKLNTQIDLIYARENGKINIYGGTFESGKYG
                     TPNNDTDGRYWVLNLKNTDKNTASIQVSGGTFINFNPANPNMDDNESYLVTGYEVTRDG
                     SVYTAAHKVNDGRKEYIVGPTSQENR"
     CDS             8595..9521
                     /locus_tag="ctg4_117"
                     /transl_table=11
                     /translation="MRIQILDYQVGPHTFRMVKPSDFNIFKALPSLIPFITTIDTTQKV
                     IFETEIDDDETATKRTIAKTPDDICFNWEDADCIIRPLPHSSHLVSITPRKSGKNYWME
                     CNDNFRQCFIHLPACRTETPAPENETNFVLNNFLMMLYAFNAARHHTLLMHASVVATET
                     GKGYLFLGKSGTGKSTHTGLWLQQFSDCHLLNDDNPIVHVDSLGKQATVFGSPWSGKTP
                     CYRKESMTVGAFVRLEQAPQNEIEQERAAHAFATLLPSCSCLKQNKEIYNAIVTTVTEL
                     ATLAPVYHLKCLPDREATELCRKTVEG"
     CDS             9548..9988
                     /locus_tag="ctg4_118"
                     /transl_table=11
                     /translation="MKKSIPNEILLPEVARLIKEGHTVTITVRGNSMNPFLVDRRDRVT
                     LGDFTTEQLQPGVAVLARDLTERIVFHRIIRRNGNILILQGDGNLAQTEETDIGRVMGV
                     MTEAMRKDKRYTADGKVWKLYSYWWMKLNPARRWLLALFRRI"
     CDS             10001..10267
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg4_119"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 9.7e-13,
                     bitscore: 41.0, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 4.5e-15, bitscore: 48.7,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIKQGFILHRIGDDYIIMQDGSSNVDFSKVISLNQTSAMLWQEI
                     ENKEFDTDSVTEALTSRYDVDNESARRDAQKFIDSLDREGIIE"
     CDS             10276..11439
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NTP_transf_5"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg4_120"
                     /sec_met_domain="NTP_transf_5 (E-value: 9.2e-46, bitscore:
                     149.3, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQHAFFSLVRSGLWGTPADRQLFRSVSPDDWETVYRMANSQALLA
                     LTFDGISSLPAELRPPRALYLKWAARTAQIEQANKRLNQLLPELNTLYREAGLHPVLLK
                     GQGIGTNYRTPLHRQCGDIDIYLGKQGQPIANRLLLQQGAIVEGEASDKHASYSLKGVH
                     IENHRIILRLNSPLANRHFQQIIRKWYPQETDYALFSETGKEDSKAVSIAIPPATFNAL
                     YIFLHAFVHFLNSGIGLRQLCDWTCLLANRHKEIDATTLLRQLQDLGLLHAAQAFGYIA
                     VTRLGLPANRLPFPLEGTKQIGEQLLEDILSTGNFGQHDNRIKPRPKGYWAGKWYTFCR
                     ATRRCNELRQFAPYEALWYPVTLIGGTIAIQINRLKGVKDKKARTKK"
     CDS             11462..13132
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 275.5; E-value:
                     1.5e-83)"
                     /gene_kind="transport"
                     /locus_tag="ctg4_121"
                     /transl_table=11
                     /translation="MKKQQKDKKVKKDRREKLRYIREVSAEQRGRILLSCLTGILGVAF
                     ALAFIYATKRVIDTATGITDDNLTHVAVLTVVLLTAQLLCGAADTWISTRMQIETGNAL
                     RHRLFSRLLQSRWNELERFHTGDVVNRVEQDTAAIVTLLTSSVPAFIVTSIQLLAAFLF
                     FYFLDPSLPWLIVAILPVFLLGSRFYMRRMKRYTHDIRNSDGRIQSVIQESLQHRIVIK
                     TLEQGERHLDKLDDLQDMLHSQVMGRTRFSLSAHMLVALAFSGGYLTAFLWGAVHLSAG
                     CITFGTMTAFLQLVGKVQRPVLDLSRLIPSVVNALTAIDRLLELERLPAEADGDSIFLA
                     STPELELKDVTFGYTPDDRPVFSRFSCRFPAGSCIAVVGETGKGKTTLIRLLLALATPQ
                     EGQILLIPAKHPLETSHTVSPQTRKNFVYVPQGNTLFSGTIRDNLLMGNPQASEEAIYQ
                     ALQTATADFVFHLPDGVDSPLSERGGGLSEGQAQRIAIARALLRPGNILLLDEATSALD
                     PDTERLLIKNLRRDCAGKTCIFVTHHPAVAEACESIVRL"
     CDS             complement(13177..14094)
                     /locus_tag="ctg4_122"
                     /transl_table=11
                     /translation="MSMKPTLFLLAAGMGSRYGGLKQLDGLGPNGETIMDYSIYDAINA
                     GFGKLVFVIRKDFEQDFRDKIISKYEGHIPCELVFQSIDDLPEGFTCPEGRTKPWGTNH
                     AVMMGADVIKEPFAVINCDDFYGRDSFQVMGKFLAALPEGSKNVYSMVGFRIGNTLSES
                     GTVSRGLCGTDANNLLTSVVERTKIQRMDGEVKYIDDNGEWTATPETTPVSMNFWGFTP
                     DYFAYSAEFFKSFLSDPKNMENLKSEFFIPLMVDKLINDGTATCEVLDTTSKWFGVTYP
                     EDRQSVVDKIQALVDAGEYPAKLF"
ORIGIN
        1 taacgcggtt ctataatcat cagattatgt tccatgtcga aagaccattg aaatatctgg
       61 gtgcggctca gcgcaatatt cagcaaatgc ttctgtgtcc gttcttccaa cacattcctg
      121 aaatagagta caatcctcac caattgtcca tcttcatgaa ttcccaccat agcaccttgt
      181 atcagaaaac tgataccact cttcaattca cgtataaagc aattgatatc taagggaata
      241 atccgcacat ccctctcccg aagttgcagc aaaaggtctt ctaacacatt ctttttatca
      301 cataccactt ccaataagtc agtgatacgc cgccctatca catactcatt caaatggagt
      361 tcattcatca cctgctgatt cagacgccag atacaatctt ccaaatcaat cataataatg
      421 ctgacgggcc atgagttgaa caactgctcg gagatggcat ttattatacg tacttcttga
      481 ggaacattcg gattcatcag aattgtttta tcatacaagg agcaaagttc gggctaaaat
      541 gcttatgcca caaacaaacc cttataaatc aatattccgt tttagcatgt atatattcta
      601 ttattcacaa ctttacctta tttaacagag acaaattgag cgtaatattg attttaactg
      661 ttatctctgt catttataca ttattatccc ccatttttgt gtcttaaaat ctccaacatg
      721 aatatatccg aattcaatat aaatgccgag ttcattgcct gcaatcatat cacaaccaat
      781 gaactgaatc cgctagtgga aaagccatac cacaccaagg ccagtatctt cgctctatgc
      841 accaaaggag ttctgaaaac tatcataaac catactcaat tcagggttga agctaacgcc
      901 ctcctagtta ttcctcccga gaccttcgta caattgctac acacgtcaga ggatgctgaa
      961 atatatgtcg ccatgttttc ccagcaactt atccaaagtg caggggccgg caagctcatg
     1021 atggataagt ttcacattat aggcaaacac tatatttttc ctctatcgaa aacggacttc
     1081 cagctttatg ccgagttcat gacctatttg tcacacctct accaaagaac agaaagcccc
     1141 tcaagtctag tttcattgca aactctactg acctatctgt tacaaggtat atccgaactc
     1201 tgtccggaac gccctagaat aaaagagact ccgggcagca ggcatttcaa ccaataccgc
     1261 atttttatcc gattggtaca cacagactat gtccgggagc atcaagtgtc ctattatgca
     1321 ttgaaaatga atatgaggcc ggcagctctt tgccgccttg tcaaaaagga atcaggacat
     1381 acagccatgg aaatcatcaa caatactatc atcatggatg ccaaagcaca gctttgtacc
     1441 gccaacactc cgataaagga tatagccgtg agtctaggtt ttaataatgc ggccttcttc
     1501 aacaaattct ttaaacgtca tacgggaata cctcctcaga agttccgtac atcctcaaaa
     1561 caataaaatc tactcaaaac acaaaatgcg gatattctgc catgagaata cccgcattcc
     1621 tcaataagag aagtctgcca tcaacctacc ttcttagcaa taaaaaacac ataaccgtag
     1681 aattccttat atttgccgta tagttcatcc tcaatcattt ggagtgagct gaactcttcg
     1741 gcaattttat taccggcata tttcttacgg aaaatctcct gggccgcaac ctttgaagca
     1801 aagtaatgct ctgtccagca attctccggc agaatgaatg tagcaacggg gagataaccc
     1861 gccttgtaca acttggctac cagattggga agtgtatcca tttcagaata ggcgtccatc
     1921 cagaagtcat tgatttccgc aggacgttcg tccgtaaacc atgaactctc ggatacggca
     1981 atataccctc ccggtttcag atatttacgc cactccttca agccacgttc aaagccgatg
     2041 ttatagatag caccttcaca ccaaatcata tccagctcct cctcaccgaa agggagggca
     2101 tccattgaac cggcaattcc ttttactctg tcctgcaagc ccaactgcct tgcattacgg
     2161 ttgaagatgt caataaagcc ggggaaaagg tcaattccgg taatctgtcc cggaacatgg
     2221 ccagccaata ccattgtctg accacccgtt ccacaaccga tatcggcaat aagggattca
     2281 tcggtaagac cgtctacaaa gctcaatgcc ttcaacgtca cttcaggact gccagggcct
     2341 tgccgttcca tattggagaa aaagtcacag attaaattaa attcgaaatc gtggatagtt
     2401 ttattttcgt tactcatttt cttactatat tttgcatata cggaaagtat cacaacacct
     2461 tcagcataat atgcggatta aacttgaatt ataacaatag aaaaacactc tcgaaagaag
     2521 ttatccgaaa gtaaacgaaa gggacaatct gtgcatggaa cacagattgt ttacaaaacc
     2581 aaatccgatt taaatgtctt tgtcatactg caaagataag caatatttta tttaatcaaa
     2641 gattttacgg ttaataaaga tttccccttg caccgggcgc atgctgaaga accgcaccta
     2701 ccacctggca agtatccagt tccttacagt cgccacaagt attgaaacct ttttcgtaca
     2761 cacatttgcg gatagcacaa taatcgctgc aataggcaaa cttcaccccg tctgcacggc
     2821 accccataca atggatggtt tccggcgtaa tttccggcgt attgttcagc acactccact
     2881 ctttggcggt tttctctctc agctcatcgt cattattgac agtggctata cgggcggcgc
     2941 aattttcgca atccaacccg caacatgcaa ttaattgttt catcacttgg ttataaccat
     3001 ttatgtgttt ctcatagcaa gcatttgtct acctcctctt tatctgaatt taagaggagg
     3061 cagacagcca tgctacaaat atacggttat tattgtgtga atgccaaatt aattttccat
     3121 cactttgctt ccacacttcc acccacctcc tgcatccccc tgtccatcgg catttgccct
     3181 gcggtggaag caacctgaaa aggtggaagc aaaatttgct tccacctgcc tgaaacgcct
     3241 gagttttgca gtaagctgct atcccctacc ataatactgc atgcagatta catgaatcgg
     3301 caggttcggt tttcctgcat tttcgggctt gtccttactg tgaagtcaac ggatatggag
     3361 ttggactgta ggagcatagt aggagttatc gggaatcaaa ggccgactat gaataatgca
     3421 ctctaatgtc ttttacaccg ttgtataata cgtttgcgcc ttgtgcgcaa taggttcggg
     3481 ctacgtactt catctgtaat agctctggag ttagtgacgc ctaacggcca tgaacaactc
     3541 tgcttacggt cgtcaaacga ttgctttatg gtcgaaagca gggttgttca tggccgttag
     3601 gcgtcataaa ttccctatgc cacagcagac aaacaaaggg agaagagtaa aggaatacct
     3661 atgttttaga taaaaatcca caagctttca ctcgtgctct ccataggtta tgagagcagg
     3721 cttcgcgctc tgtgcgataa attcccattt atcagcaggc atactcactt acgaaacttc
     3781 aattacttat ataaattgtt tcagccaaag gcagtacgga catttgctaa aatatggaaa
     3841 gtcttattat gaaaaattgc tatggcatcg acttccgttc gtggcgtaag gagctacgta
     3901 cacgcgagaa aaccaagcag ccaccctgca aactgccgga cagagcaagc cggagtttgc
     3961 agggtgttct gtttaaagta tatcaaatct ctgttttaat tttgcttaaa aagattttat
     4021 tcagcttctt ttcggtctgt cttcccctct ttattcgcca catagccgct atgctcctca
     4081 gaaaaacatc ctcaaagaca atgcagacag ttactaaata tttgaaggag ttatcgggag
     4141 ttagaagtga taactctcct aactcctata aatgaaagag acgtgagcct ttcccaaaaa
     4201 aaatagagaa acatagatac acttaaacaa aaaacaatta tctttgtcac aaatccgcta
     4261 tagcgtagtg ggtttattta catattagta agagcattat tgaaattatc ttctttattc
     4321 aaacttcgca actttgaaaa tttccctgaa gataacaaca aggatgctca cgtctatgtt
     4381 tatatggttt tctcccatca ggggggatgg tatatacaca aacgacgtga gtgactgttg
     4441 tatatccagg gaaagggcaa tgcgaaggcc tgaataaagg atatacaaac atagttactc
     4501 acgttttttt tattgtttaa cttttaaata atttgtgtat atgaaacaga acacaccaga
     4561 cggtagagaa gcatacatca ctccgtctat cgaagttatc aaaatggaga atgaaggagt
     4621 cattgcaaca agcggcgaac cttaccatcc cattacgcgc tcctattcgg gcagcacctc
     4681 tacccatagc tacaattcgg catccagcag cgacttggaa gacctaatca atgacatctt
     4741 aaccgtagaa aactaagggg gacttcatta tgatgaaatt aagaaacctt atgcaagttg
     4801 cctgcatggc aactgctgcc ttgaccgcat tcagttgcag ccaagaggaa tttgaaaaca
     4861 gcgggcggaa aggaaacatc accgttaacg caacgtttga aggcgcaggt accgacaccc
     4921 gtactaccgt aaacgatgaa tacaagattc tatggcaaga taccgatgcc ctagggttgt
     4981 tctgtagtaa tgcagaaagt aattatagca atacaaaatt agaatatgca agcggtgctg
     5041 gtcaaacttc cgccactttc aacggcagca agccaagcgg agaaacggct gtattctcca
     5101 tctatcctta ccaacaaaac atgagcgtaa gcggcaatac attgaccatg actctacctg
     5161 ccacgcttac aaattataac ggcagcagca atggcccgat gtatgccaag gtgacaaatc
     5221 ccgacaatct gagcgctctg tccttcaagc acatggcagc catgataaaa ctgaccgtca
     5281 acaagattcc ggcagaggcc actactttca agattattgc ctccaataac attgcaggta
     5341 cttgtacggt agacttaacc gcagcagacc cgatactggc agtaacgagc gatgaaagca
     5401 aggaaatcac cgcctccttc acagcctcag ctgatataaa gtctcgcaac ttctacattc
     5461 ctttgcccac aggtacttat agttccatca ctgcccaact gacgaatgga agcgacaagg
     5521 tatattttac caagacgctt aatgacaaaa tcctaggcag aagagacata ttggtagtac
     5581 ctcctttgga ttgcgttgtg gtagaggcta caacccccag tgcgcttagt acagctttag
     5641 ctgattcaaa aaatctccca caagaagcac cgacagcagc aaccgtaacc gacattgcag
     5701 tcagcggcag cttcaatacc acttctggca gcaacgacgg catcgccatc ccggttttac
     5761 agaactcgga catcaacctg gcgttcaata cagccccgac aaccagcact tctgccccgt
     5821 taaagctgac cgacaagacc aataccagcg taagtactcc cgccgccact gccaccaaca
     5881 gtgtatcctt ggctgtgccg gaaaccacag cagagcaaga agctccttct gtagccatca
     5941 ccatgccaag caccaccgtt acattggcag cagtaggcaa taaagccact tacaatgaag
     6001 tgactgccac taccgcccag cagacattga ttatcaatgc aggcgtcacc gtaaagaagc
     6061 tgaccgtaaa aggcggtaac ttgaagatat atggaaaggt agaacaattg gtacacgatg
     6121 ccggcaatac cacaatctat ataataaaag gaactgaagc atcacttccg gcaacaatcg
     6181 acagcaaatt tgtagttcaa tccgacgtgg cagtcctaaa gaccgctttc gccaacggcg
     6241 aagattttaa attgtccgcc gatgccgaca tcacagggca aagcgtcagt gtacccgccg
     6301 gaaagtccgt ggttcttgac ttgaacggat atacactgac tgccgacaac agcgcaacag
     6361 gcaaaatcat cgtcttgggc aagatgacac tgaaggacag ctctaccgag aagaaaggca
     6421 agatagttgc cagccaggat tatacagcgg cttcttataa tggcagtctg attgaaatag
     6481 ccggtgaaga tgcctccatg accatggaaa gcggcaacat cagtgcagtc agaaagactc
     6541 cgaacagtaa cggccaatat ggcgtcggag tgacggacgg tggagacttc accatgacag
     6601 gcggcaagat agaagccgga tggtttgcag tggcaggcaa cggcaattac aagacgcaga
     6661 actccatcat caacatcaca gacggagaac tcatttctac tgctgactat gcagtctatc
     6721 tgccccaatc cggcacaacg accatcagtg gcggcaaggt ttatggtgcc gcaggaggtg
     6781 tatgcatcca acgaggcact ctgaacgtgg aaggcacagc cttgattacc agtaaaggca
     6841 caggcagcac cggcaactgg ggcgacggta ccggaggact ggactgcgcc gccatcaacg
     6901 taagtggagc atatggcatt gccacagtaa acatcaaagg cggtacactg attgccgaag
     6961 caaagtcact catcacagaa ggcaccactt atacaccggt catcaacgtt accggcggta
     7021 cattctccga cccaagcgcg ctgaagtaca tgaagacaaa tgcaaatgtg aacataaagt
     7081 tgaccgccga caagacctgc ccgggattca agaccacaag cggacaaacc ttgacgatgg
     7141 acttaggcgg caagatcctt acacttgctg acccgaccgt aggttccacc ggcaccgaaa
     7201 cgaacagctg tcaattactc gaaggttcaa acgttacttt caagaacgga acgctgaaga
     7261 gtgacaacaa caaaatcatg attcagaact actgcaacct gacattagat aatatgacag
     7321 tagaagacac aaatgcccaa tacgtagtaa gcaacaattg tggcaatata agcatcaaca
     7381 ataccactat caacgcagga agcaatgcga atcaatttgc attcgacgta tgcggctatg
     7441 caaagtacac tgctggagtc acggttacgg taagcggtac gagcgtcatc aatggaaaag
     7501 tggaaatttc caagagtgca ggaaataccg aacctatgaa gctgaatatc acaggcggta
     7561 ctttcaacgg tgacttaaag gtagatgcat ccgtgggaac cgaaaatgcc aaaagtatca
     7621 tctctgtttc cggaggtaca ttctccgacc caagcgtact gaagtacatg gcaaccaacg
     7681 caactgtgga tataaaactt ctctcaaata tcaacatcgc caagacggag cttgccacag
     7741 gctacatatt gaatgctgca aacgcaacgg caaacttaaa cctgaatggc cacgacatca
     7801 tcaattcctc agaaacagct gatgccactc ctttcacaca aatctttact gtacagaacg
     7861 gaacactaaa catttcaggc aacggcaatg tgaagtgcga tgcatctgct acagcgaaag
     7921 acgatggtta tcgcatggta attgaagccc gaggacacgg gacagtaaat attcatggcg
     7981 gttcttacta taacacccag aaactgaaca cccagataga cctgatttat gcaagagaga
     8041 atgggaaaat caatatctat ggaggaacat ttgaatccgg caaatatggt acacccaaca
     8101 acgacacgga tggcagatac tgggtactga acttaaagaa tacagacaag aacactgcca
     8161 gcatccaggt gtccggtgga acgttcatca atttcaaccc ggcaaatccg aatatggacg
     8221 acaatgaatc ctatttggta acaggttacg aggttacccg tgacggcagt gtatatacag
     8281 cagcccacaa agtcaacgat gggaggaaag aatatattgt tggcccaaca agtcaggaga
     8341 accgataagc caaattctaa gaaaggaagc aatatatcct cgcagaccaa acgaagaggt
     8401 atcggaatcg ccttattact atcttttaga tgcggcggac agcggatttt cttttataaa
     8461 tctgcgtcct ccgcgtctaa aaaatgacaa caagacagtt gaaaaatctc tcaaatcttc
     8521 ctcattcaca caaacattca ttatttttct gagtagccca aagtatcatg aataacaact
     8581 aacaatcaaa acatatgaga atacagatat tggattatca agtaggaccg cacaccttcc
     8641 gcatggtgaa accttccgac ttcaatatat tcaaggcgtt gccttcactg attccgttca
     8701 tcacgacaat agacacgacg caaaaagtaa tctttgaaac agagatagac gatgacgaaa
     8761 cagcgacaaa acgaaccata gcgaaaactc ccgatgatat atgtttcaac tgggaagatg
     8821 ccgattgcat cattcgccct ttgccccaca gctcacacct tgtatccatc accccacgga
     8881 aaagcgggaa aaactattgg atggagtgca acgataactt caggcaatgc ttcatccacc
     8941 taccggcctg caggacagaa acaccggctc cggaaaacga aacgaacttc gtactgaaca
     9001 acttcttgat gatgctctat gccttcaatg ccgcccgcca ccatacactg ctgatgcatg
     9061 cctcggttgt cgctactgaa acaggcaaag gctacctctt cttagggaaa agcggcacgg
     9121 gcaaaagtac gcacaccggg ctctggctgc aacagttctc ggactgccat ctactgaacg
     9181 atgacaatcc gatagtacat gtggacagcc tcggcaagca agccactgtt ttcggttctc
     9241 cgtggagcgg aaagacacca tgctatcgga aagaatccat gaccgtaggc gccttcgtcc
     9301 gcttggaaca agcaccgcag aatgaaatag agcaagagag agcagcacat gctttcgcca
     9361 ccctcctccc ctcctgctct tgcctgaagc agaacaagga aatctataac gccattgtca
     9421 ccactgtgac ggaacttgcc acgctggcac ccgtctatca tctgaaatgc ctgcccgacc
     9481 gtgaagcgac ggagctttgc agaaagacgg tagaaggata agttatgaat gatgaactga
     9541 acagccgatg aagaaaagca ttcccaacga gatattgctt cccgaagtgg cgcgtctcat
     9601 caaagagggg catacagtaa ccatcaccgt gcggggcaac agcatgaatc ctttcttagt
     9661 ggaccgccgt gaccgggtga cactgggcga tttcaccaca gaacagctgc aaccgggcgt
     9721 cgccgtactg gcacgcgacc tgacggaacg catcgtcttt caccgcatca tccgtcggaa
     9781 cggaaatata ctcatcctgc aaggcgacgg caacctcgcc cagaccgaag aaaccgacat
     9841 cggacgggta atgggcgtca tgaccgaagc catgcgaaaa gacaaacggt acaccgccga
     9901 cggcaaagtc tggaagctct actcctactg gtggatgaag ctaaaccctg ctcgccgctg
     9961 gctgctcgcc ctgttcagaa gaatataaaa caaaataacc atgaaaatca aacaaggatt
    10021 tatcctgcac cggataggcg atgactacat catcatgcaa gacggctcgt cgaacgtgga
    10081 cttcagcaaa gtcatcagcc tgaaccaaac ttccgccatg ctttggcaag agatagaaaa
    10141 caaagagttc gatacagaca gcgtgacaga agccctgacc agccgctatg atgtagataa
    10201 cgaatcggcc cgtcgcgatg cgcagaagtt tatcgactcc cttgaccgcg aaggaatcat
    10261 agaataagga cggatatgca acacgctttc ttttcattgg tacgctccgg cctgtggggc
    10321 actccggcag accgacaact cttccggtcg gtctcgccgg acgactggga aaccgtgtac
    10381 cgcatggcaa actcacaagc cctgcttgca ctgacttttg acggcataag cagtctaccg
    10441 gccgaactgc gccctccacg cgccctctat ctgaaatggg ctgcccggac tgcacagata
    10501 gaacaagcca acaaacgcct caaccagctt ctgcccgaac tcaataccct ttaccgggaa
    10561 gccgggctgc atcccgtact gctgaaaggg caaggcatcg gcaccaacta ccgcactccc
    10621 ttgcaccggc aatgcggaga catcgacatc tatttaggaa aacaaggaca acccatagcc
    10681 aaccgcctcc tgctgcaaca aggcgccata gtcgagggag aagcgtccga caagcatgcc
    10741 agctacagtt tgaaaggagt acacatcgag aaccaccgca tcatcctccg gctgaacagt
    10801 ccgcttgcca accggcactt tcagcagatt atcagaaaat ggtatccgca ggaaacagac
    10861 tatgccctat tctccgaaac cgggaaagag gactcgaagg ccgtcagtat cgccatacct
    10921 ccggccacct tcaatgcact ttatatcttc ctacatgcct ttgtacattt cctgaacagc
    10981 ggaatcggcc tgcgccagct atgcgactgg acttgtctgc ttgccaatcg ccacaaagaa
    11041 atagatgcca ccaccctgct tcgccagttg caggacctcg gactattgca tgccgcacaa
    11101 gcattcggct acattgccgt cacccgactg ggattgcccg ccaaccggct tcctttcccc
    11161 ttggaaggca ccaagcagat aggagaacaa ttattggaag acatcctgtc taccggtaac
    11221 ttcgggcaac atgataaccg catcaagcca cgccccaaag gatattgggc aggaaagtgg
    11281 tacaccttct gccgcgccac ccgacgctgc aacgaactgc gtcaatttgc accgtacgaa
    11341 gcactctggt atcccgtgac tctgataggg ggaacgatag ctatacaaat aaaccgatta
    11401 aaaggagtaa aagacaagaa agcaaggaca aagaaataaa agaacccgga aaataaaagg
    11461 aatgaaaaag caacagaagg acaaaaaagt gaaaaaggac agacgtgaaa aacttaggta
    11521 tattcgagag gtatctgccg aacaacgcgg acgtatcctg ctaagttgcc tcaccggcat
    11581 tctgggcgtg gcctttgccc tagcctttat ctatgcaacc aaacgggtga tagacaccgc
    11641 taccggaata acagacgaca acctgacgca tgtcgccgtt ctcaccgttg tcctgctgac
    11701 tgcccaatta ctgtgcggag ctgctgacac ttggataagt acccgtatgc agatagagac
    11761 gggcaacgcc cttcgccacc gcctcttctc gcgcttactg caaagccgct ggaacgaatt
    11821 ggagcgtttc cataccggag acgtagtgaa ccgggtagaa caagacaccg ccgccatcgt
    11881 cacattgctc acctcttctg tcccggcatt catcgtcacg agtatacaac tgctggcagc
    11941 ctttctattc ttctactttt tagacccttc actgccatgg ctgattgttg ccatcctgcc
    12001 cgtctttcta ttaggcagcc gtttctatat gcgacgaatg aaacgctata cacatgatat
    12061 tcggaacagt gacggtcgca tccagtccgt catacaagag agcctgcaac atcgcatagt
    12121 gattaaaaca ttggaacaag gcgaacggca tctggacaaa ctcgatgact tgcaagacat
    12181 gctccacagc caagtcatgg gacgtacccg tttctcgctt tccgcccaca tgttagtggc
    12241 ccttgccttt tccggcggat acctcacggc ttttctttgg ggagccgttc acctcagcgc
    12301 aggctgtatc accttcggaa cgatgaccgc ctttttgcaa ttggtaggaa aagtccagcg
    12361 tcccgtgctc gacctctcac gcctgatacc ttccgtagtc aatgccctta ccgccataga
    12421 ccggctattg gaattggaaa gactgccggc agaagcggac ggtgacagca tattcctcgc
    12481 ctctaccccg gaactggaac tgaaagacgt gacttttggc tacactcccg atgaccgtcc
    12541 ggtattcagc cgcttctcct gccgtttccc cgccggtagc tgcatagctg tagtcggaga
    12601 aacaggaaaa ggaaagacaa cgctcatccg gctattgttg gcactggcaa cgccacaaga
    12661 gggacagata ctcttgatac ccgccaaaca tccacttgaa accagtcata ccgtctctcc
    12721 gcaaacccgc aagaacttcg tatatgtccc gcaaggcaat acccttttca gcggaactat
    12781 ccgtgacaac ctgctgatgg gaaacccaca agcttctgaa gaagccatat atcaagccct
    12841 gcaaaccgcc accgccgact tcgtcttcca ccttcccgac ggcgtagact ccccactcag
    12901 cgaacgaggt ggcggactca gtgaaggaca agcccaacgc atcgccattg cccgcgctct
    12961 gctacgcccc ggaaacattc ttcttttaga tgaagccact tctgccctcg accccgacac
    13021 ggaacggctg ttaataaaaa acctgcgcag agactgcgca ggcaaaacat gtatcttcgt
    13081 cacccaccat ccggcagtag cggaggcatg cgaatctatt gtccgattat aatcagagaa
    13141 tgagccccaa cgggtatctg cctttggtta acaaactcag aacagctttg caggatactc
    13201 gcctgcatcc accaaagcct gaatcttgtc gactacactc tgacggtctt cgggataagt
    13261 cacaccgaac cacttgctgg ttgtgtcgag cacttcgcag gtagcagtgc catcgttaat
    13321 cagcttatcc accatcagcg ggatgaagaa ttcgctcttc aggttctcca tgttcttcgg
    13381 gtcgctcaag aaactcttga aaaactctgc actgtaagca aagtaatcgg gagtgaaacc
    13441 ccagaagttc atgctgaccg gagtcgtctc gggagtggca gtccattcac cgttatcatc
    13501 gatgtatttc acctcaccgt ccatgcgctg aatcttggtg cgttccacta cggaagtcag
    13561 caggttgttc gcatccgttc cgcacaatcc acgggatacg gtaccgcttt cgctcaacgt
    13621 gttgccgatg cggaagccta ccatggaata tacgtttttg gagccttcgg gaagggctgc
    13681 aagaaattta cccattacct ggaaggaatc acgaccgtag aaatcgtcgc agttgataac
    13741 agcaaacggt tcctttatta catcggcacc catcattaca gcatggttgg ttccccaagg
    13801 tttggtacgg ccttcggggc aagtgaagcc ttcgggaagg tcatcaatgg actggaatac
    13861 cagttcgcac ggaatatggc cttcgtattt ggaaataatc ttgtcgcgga aatcctgctc
    13921 aaaatcttta cggataacaa acacaagctt gccaaagcct gcattgatgg catcgtaaat
    13981 agaataatcc atgatagttt cgccattcgg gcccagtccg tccaattgtt tcaagccacc
    14041 ataacggctg cccatgccgg ctgccaataa gaataaagtt ggtttcatac ttagtt
//
