LOCUS       gnlProkkaHDFOCCGP_74   13604 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|HDFOCCGP_74.
ACCESSION   gnlProkkaHDFOCCGP_74
VERSION     gnlProkkaHDFOCCGP_74
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-17 21:45:25
            Original ID  :: gnl|Prokka|HDFOCCGP_74
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13604
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..894
                     /locus_tag="ctg74_1"
                     /transl_table=11
                     /translation="MVTFPKTVGQIPFNFPCKPSSQIDGGKNPGPTGNMSRINGALYPF
                     GYGLSYTTFEYSDLDITPRVITPNESATVRLKVTNTGKRAGDEVVQLYIRDVLSSITTY
                     EKNLAGFQRIHLEPGEAQELSFTIDRKHLELLDADMKWVVEPGDFVLMAGASSEDIRLN
                     GTLTVEDYQTRAKAIEAQKPAKRVSASTNPEDAENVLDEKINTAWQGNKGDYITFALKN
                     GTQVDKVTIAFTRDNNLPATFEIQLSGGGGQFLTVYSGTVSEYGKLISYPFKGTTASDL
                     RIVLNDDRVSIAEVKF"
     protocluster    1..13604
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[3250:3604]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      3251..3604
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..13604
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13604
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             996..2123
                     /locus_tag="ctg74_2"
                     /transl_table=11
                     /translation="MKTLLFCMLGLGLTACGSSPKGTNGDQDELAMLIGTYTNGSSKGI
                     YTFRFNQETGTAVPLSSAALPNPSYLVPSEDGEFVYAVSEMNDSTAALSSLALDRETGE
                     LRLLNTVPTFGADPCYVATNGREVLTANYSGGTMSVFPLQKDGTLAPADTLFQGSATGP
                     DAIRQATPHIHCTVFSPDGKYIFATDFSADRILRFVMHPDDPIPHASLEAVDIEADSGP
                     RHLTFSPNGKFAYLITELSGKVIAFSYDDGCLEQIQTITADTVAARGSADIHLSPDGKY
                     LYASNRLKEDGIAIFAVNPENGTLAKVGYQPTGIHPRNFNITPNGKYLLAACRDSNVIQ
                     VYKRNEVTGLLEDTHQDIVVDMPVCVQFVSSVNNL"
     CDS             2194..3243
                     /locus_tag="ctg74_3"
                     /transl_table=11
                     /translation="MKKNILMLSALFLSITAMAQTDVTTGVMRGKDYGVTYMLPKTEIE
                     IVLQATKHTYTPGEFCRYADRYLRLNNVSAEPEEFWTLDKIETRIAGVPDKDNVYFVKM
                     KDKTVAPLMELTEDGIVRSINIPFSGKPAAKTPEAKATESSIDPRSFLTEEILMSNSSA
                     KMAELVAKEIYSIRESKNALLRGEADNMPKDGAQLKLMLDNLNQQETAMTEMFSGKIKK
                     EPKTFTIRLTPKEMKDEVAFRFSRKLGVVANNDLAGEPYYISVTDLKSPDVSATEEGKK
                     KVDGVAYNLPGKAQVTLMYNNKKLFDDQLPITQFGTVEYLAPVLFNKNSTIKVLFDTAT
                     GGLIKVDRE"
     CDS             complement(3251..3604)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg74_4"
                     /sec_met_domain="PqqD_RRE (E-value: 1.2e-10, bitscore:
                     30.9, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 2.1e-17, bitscore: 53.1,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMEIPEGKVSLLDAVPVRCGHITTEWEGECAVLAYPRFKYEWMRR
                     FLLPKGMSPDIHVRLEEHGTAVWNLIDGHRTVREIISLLARHFGEEENYIPRVTAYVMQ
                     LRKDGFIQLTIRN"
     CDS             complement(3624..5015)
                     /gene_functions="transport (smcogs) SMCOG1106:major
                     facilitator transporter (Score: 100.6; E-value: 1.2e-30)"
                     /gene_kind="transport"
                     /locus_tag="ctg74_5"
                     /transl_table=11
                     /translation="MTEQLKLKLNDSKATRWGALVIVAFTMMAAYYVNDVVAPLKTMLE
                     TDLAWSSTDFGFFTGGYSFLNVFFLMLIWGGLILDRFGIRFTGKLATILMVGGTALEYY
                     AMTGLAGADATLFGINEIFGYKTGVFVAFAGYSIFGVGAEVAGITVSKIIAKWFKGKEL
                     ATAMGVQVALARIGSQAGYAVAIPLARAFGISTPVLLGLVLLLGGMIAFFIFAVMDKKL
                     DKQMEAAAIAAGTEDEEEKFSFKDVKNILVNPGFWLIALLCVLFYSCVFPFQKFASELM
                     IIKYGINENVAGTFAGLPALGALILTPVFGGFIDKRGKSASIMLLGSAMLICVHFIYAI
                     PDINYWLVAIVLMIILGIAFSLVPSAMWPAVAKIFPVSQLGTAYALIFFIQNIGLWGIP
                     TLIGWVLDAYCISGKKPDGTNMYDYTVPMCIFTGIACLSLIVALLLKKADKKYGYKLEE
                     PNIQK"
     CDS             complement(5169..5558)
                     /locus_tag="ctg74_6"
                     /transl_table=11
                     /translation="MYLLLVILMLIASVLMCFIVLIQNSKGGGLASGFSSSNQIMGVRK
                     TTDFLEKATWTLAAVMVVFSIVSAYTIPSSTGKGGDVILEQAQQEEKTNPYNMPVGTEA
                     PQSEAPAATTPAEAPAPAAEAPAAE"
     CDS             complement(5563..6336)
                     /locus_tag="ctg74_7"
                     /transl_table=11
                     /translation="MTPTHLQQWIQHPETLNRDTLYELRTLVARYPYFQSLRLLYLKNL
                     YLLHDINFGAELRKAVLYVADRRVLFYFIEGDRYTLKSRKVSSLFSGDLEKEPSVDRTL
                     SLIDAFLATVPEEHSQHTELDYAVDYTAYLMQEEPGVDAEDESEVPKLRGHELIDDFIQ
                     KSESSDASDTRREFLVEKEEETEEEEEPSVSPVTEELDDSCFTETLAKIYIKQHRYDKA
                     LEIIKKLSLNYPKKNAYFADQIRFLEKLIINAKSK"
     CDS             complement(6341..6865)
                     /locus_tag="ctg74_8"
                     /transl_table=11
                     /translation="MDWIKKAAFASLLVSLLFLVNSCSMKLGLAPISSIDYTKVKTISI
                     ADFQNRAEYVYAPLATEFNQKMKDMFIQQTRLQLVNSGGDLEIDGEITGYNQYNESVDA
                     SGYSSKVKVTLTVNVRYTNNTNHEEDFEQQFSAFQTYDSSKLLTEVQDQLITLMVKDIA
                     EQIFNATVANW"
     CDS             complement(6852..8102)
                     /gene_functions="regulatory (smcogs) SMCOG1112:sigma-54
                     dependent trancsriptional regulator (Score: 379.9; E-value:
                     3.1e-115)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg74_9"
                     /transl_table=11
                     /translation="MTKAEIQQVKLRFGIIGNNEALMRAIDIAIQVAPTDLSVLITGES
                     GVGKESFPQIIHQYSRRKHGQYIAVNCGAIPEGTIDSELFGHEKGAFTGAIGERKGYFG
                     EANGGTIFLDEVGELPLPTQARLLRVLESGEFIKVGSSKVEKTDVRIVAATNVNLTQAI
                     ADGRFREDLYYRLNTVPIQVPPLRERGEDVVLLFRKFASDFAEKYRMPAIQLTEDGKQV
                     LLGYSWPGNVRQLKNITEQISIIETNREINASILKGYLPEQNNMQRLPALFGVKEDKSF
                     GSEREILYQVLFDMRQDVTDLKKLVHEIMAERGTVANPAVATSAYYTPATPAVVPPVTS
                     SVPTIIHPSVKPVTPVDDDFQDTEEYVEESLSLDEVEKEMIRKALEKHHGKRKSAAQDL
                     NISERTLYRKIKEYGLD"
     CDS             complement(8104..9201)
                     /locus_tag="ctg74_10"
                     /transl_table=11
                     /translation="MEDNKIRVGITQGDINGVGYEVILKTFADPVMLELCTPIIYGSPK
                     VAAYHRKSLDLPTNFSIVNSASEAVPNRLSVVNCTDDEVKVEFSKPDVEAGKAALGALE
                     KAIEEYKEGMIDVIVTAPINKHTIQSEEFAFPGHTEYIEQKLGDGEKALMILMKDDFRV
                     ALVTGHIPVKEIAGSITKELIQEKLKIFNRSLKQDFAISAPRIAVLSLNPHAGDGGLLG
                     TEEQEIIIPAINEMAAKGMLCYGPYPADGFMGSDNFTHFDGILAMYHDQGLAPFKALAM
                     DEGVNYTAGLPVIRTSPAHGTAYDIAGKGIASEDSFRQAIYVAIDVFRNRQREKEAHAN
                     PLRKQYYEKRDDSDKLKLDSVEEDL"
     CDS             complement(9207..10262)
                     /locus_tag="ctg74_11"
                     /transl_table=11
                     /translation="MRKHLFYLSMVLVLTLFSACGGGKKGVFTPTSSGRAYEVLVVVEP
                     GLWERPAGRALFDVLDSDVPGLPQSERSFRIMYTAPSNYDATLKLIRNIIIVDVNKDLY
                     TQPKFKYARNVYAAPQSILTIQAPDEASFEKFVEENRQVIIDFFTHAEMNRQISVLKDK
                     HSDYIATKVKSQFDCDVWVPGELTSTKEGENFFWAGTNAATGDQNFVIYSYPYTDKDTF
                     TKEYFVHKRDSVMKVNIPGAREGMYMSTDSLMTDVRPISVQGDYALEARGLWRIKGDLM
                     GGPFVSHVRLDKANQRIIVSEIFIYSPDKMKRNLVRQMEASLYTLKLPGSKQEGAEIPV
                     GVTSKDTTNNK"
     CDS             complement(10333..11373)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg74_12"
                     /sec_met_domain="PF04055 (E-value: 2.2e-17, bitscore: 53.7,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQKRPLLGLTLSELQNVVKNLGMPGFSAKQIASWLYDKKVTSIDE
                     MSNLSLKHRELLKEIYEVGAEAPVDAMRSVDGTVKYLYRAGEGHFVEAVYIPDEDRATL
                     CVSSQVGCKMNCKFCMTGKQGFTANLTSNQIINQINSLPERDKLTNVVMMGMGEPLDNL
                     DEVLKALEIMTASYGYAWSPKRVTLSSVGLKKGLQRFIEESDCHLAISLHSPIPLQRRE
                     LMPAEKAFSITEIVELLRNYDFSKQRRLSFEYIVFKGVNDSLPYAKELLKLLRGLDCRI
                     NLIRFHAIPGVNLEGADMETMTAFRDYLTSHGLFTTIRSSRGEDIFAACGMLSTAKQEE
                     NKEELI"
ORIGIN
        1 acggtgacct tccccaagac cgtagggcaa atccccttca acttcccctg caaaccttct
       61 tcacagatag acggcggtaa gaatccggga cctacgggca acatgtcacg catcaacgga
      121 gcactctacc ccttcggtta cggcttgagc tacaccacct tcgagtactc cgacctcgac
      181 atcacccccc gagtcatcac cccgaacgag tctgccaccg tccgcctgaa ggtgaccaac
      241 accggcaaac gtgccggaga tgaagtagtg cagctctata tccgcgacgt actgagcagc
      301 atcaccacct acgaaaagaa tcttgcaggc ttccagcgca tccacctcga accgggcgaa
      361 gcccaggagc tgtccttcac catcgaccgc aagcacctgg agcttctgga cgccgacatg
      421 aaatgggtgg tggaacccgg cgacttcgtg ctcatggccg gcgcctcttc cgaagacatc
      481 cgcctgaacg gaacgctgac cgtagaagac taccagaccc gtgccaaagc cattgaagcc
      541 caaaaaccag caaagcgtgt gagtgccagc accaacccag aggatgccga aaacgtgctc
      601 gacgaaaaaa tcaataccgc atggcaagga aataagggag attatattac ctttgccttg
      661 aagaacggaa cccaggtaga taaagttacc atcgccttta cacgtgacaa caacctgccg
      721 gcaaccttcg aaatccagct ctcgggcggt ggcggacagt tcctcaccgt atattcgggc
      781 accgtcagcg aatacggcaa actgatttcc tatccgttca aaggcactac cgccagcgac
      841 ctccgcatcg tgctgaacga tgaccgcgtc agtattgccg aagttaaatt ttaatgtgct
      901 aatgtgccaa tatgctaatg taccaatgac catgcagcat atacagcgca gccaattagc
      961 acattagcat attggcacat taacacatta aattaatgaa aacacttctt ttctgtatgc
     1021 tcggattagg tttgacagca tgtggctctt ctccaaaggg cactaacggt gaccaggacg
     1081 aactcgccat gctaataggt acttacacga atggctcaag caagggtatc tataccttcc
     1141 gctttaatca ggagacggga acagccgttc cgctcagttc agcggcattg cccaatccct
     1201 cctacctcgt cccctcggaa gatggcgaat ttgtctatgc cgtcagtgaa atgaacgaca
     1261 gcacagcagc cctcagctcc cttgccttag accgggaaac gggagaactg cgcctgctga
     1321 acaccgttcc caccttcggc gccgacccct gctacgtggc caccaatggc cgggaagtgt
     1381 tgactgccaa ctacagcggt ggaaccatgt ccgtctttcc tttacagaaa gacggtactt
     1441 tggctcctgc agacacgctc tttcaaggct ctgccaccgg tcccgacgcc atacggcaag
     1501 ccactcccca catccattgc acggtctttt caccggacgg aaagtatatc ttcgccaccg
     1561 acttcagtgc cgaccgcatc ctgcgctttg tgatgcaccc cgacgaccct attcctcatg
     1621 cttctctgga agccgttgac attgaagcgg attccggccc gcgccatctg acattcagcc
     1681 ctaacgggaa gtttgcctat ctcatcaccg aactgtccgg taaggtcatt gccttcagtt
     1741 acgacgacgg ctgcctggaa cagatacaga ctatcacagc cgacaccgta gccgcccgtg
     1801 gaagtgcaga catccacctc agtccggatg ggaaatacct ctacgccagt aaccgtctga
     1861 aagaagacgg catcgccatc tttgccgtga atcccgaaaa tggaaccttg gcaaaggtag
     1921 gttatcagcc caccggcatc catccccgca acttcaacat cacgcccaac ggcaaatact
     1981 tgcttgccgc ctgccgcgac agcaatgtca ttcaggtata caaacgaaac gaagttaccg
     2041 gactcttgga agatactcat caggacattg tagtcgacat gccggtttgc gtacagttcg
     2101 tcagctctgt taataattta taaagcaata tttagcaaag ataacttcat taactttgtc
     2161 ccttagctaa atcagtctaa acgaatgtac attatgaaga agaatatatt gatgctctca
     2221 gctctgttct tgtctatcac tgccatggcg caaacagacg taaccaccgg tgtgatgcgt
     2281 ggcaaagact acggagtgac ttatatgttg cccaaaacag aaatagaaat cgtattgcaa
     2341 gccaccaaac atacttacac tcccggagaa ttttgcagat atgccgaccg ctatctgcgt
     2401 ctcaacaacg tgtctgccga acccgaggag ttctggacac tggataagat agaaacccgc
     2461 atagccggtg taccggataa ggacaacgtc tatttcgtga agatgaaaga caagaccgta
     2521 gcacccctta tggagcttac cgaagacgga attgtccgct ccatcaacat tccgttcagc
     2581 ggtaagcctg ctgccaagac gcccgaagcc aaagccaccg aaagcagcat tgacccacgc
     2641 agttttctga cggaagaaat actgatgtcc aactccagtg ccaagatggc cgagctggtg
     2701 gctaaggaaa tatacagcat ccgcgaaagc aagaatgccc tcctgcgcgg cgaagcagac
     2761 aatatgccca aggacggcgc ccaactcaag ctgatgcttg acaatctgaa ccagcaggaa
     2821 acggctatga cggaaatgtt ctcgggcaaa ataaagaaag aacccaagac attcaccatc
     2881 cggctgacgc ctaaagagat gaaagatgaa gtggctttcc gtttttcccg aaagctggga
     2941 gtggtggcca ataatgacct tgccggtgaa ccgtattata tcagcgtcac cgacctcaaa
     3001 agtcccgatg tatctgccac cgaggaaggc aaaaagaaag tggacggtgt agcctataac
     3061 cttccgggca aggcacaagt gacattgatg tataacaata agaaattgtt tgacgaccaa
     3121 cttcccatta cccaattcgg caccgtagaa tacctcgcac cggtactgtt caacaagaat
     3181 tctaccatca aagtgctgtt tgatacggca acgggaggat tgataaaagt ggatagggaa
     3241 taaaggaatt ctaattccgg attgtcaact ggataaatcc atccttacgc aactgcatta
     3301 cgtaggcggt gacccgggga atataattct cttcctcccc aaagtgcctg gcaagtagag
     3361 agatgatttc gcgcacggta cgatgtccat ctatcagatt ccagacagct gtaccgtgtt
     3421 cttccagcct cacatggatg tcaggagaca tccccttcgg caataaaaaa cgacgcatcc
     3481 attcgtattt aaaccgtggg taggcgagta cggcgcactc accttcccat tcggttgtta
     3541 tatgtccaca gcggaccgga acagcgtcca acagacttac ttttccttcg ggtatttcca
     3601 tcatacggta tccgcttttc ctattatttc tgaatattag gctcttccag cttataacca
     3661 tacttcttgt ctgccttctt cagcagtaga gccactataa gggacaagca ggcaataccg
     3721 gtaaaaatgc acataggcac cgtatagtca tacatattcg ttccatctgg tttcttgccg
     3781 gatatacaat aggcatcaag cacccaccct atcaatgtag gaatacccca aagaccgata
     3841 ttctggataa agaaaatcaa tgcgtatgcc gtacccaact ggcttaccgg gaatatcttg
     3901 gccacagccg gccacatggc agaaggtacc agcgagaaag cgatacccaa aattatcatc
     3961 agcacaatag ctaccagcca atagtttata tcgggaatag cataaatgaa atgcacacat
     4021 atcagcatgg ccgagcccag cagcatgata gatgcggact tgccccgctt gtcaatgaaa
     4081 ccaccaaaga ccggagtcag aatcagcgct cccaatgccg gaagtccggc aaatgtaccg
     4141 gctacattct cattgatacc gtatttgata atcatcaact cggaagcaaa cttctggaat
     4201 gggaatacac aagagtagaa caatacacac agcaatgcta tcagccagaa accgggattg
     4261 accagaatat tcttcacatc cttaaaagag aacttctctt cctcatcttc cgtaccggca
     4321 gcaatggcag cagcttccat ctgtttgtcc agcttcttgt ccatcactgc aaagatgaag
     4381 aaagcaatca taccgcccaa caacagaacc aaacccaaca acaccggtgt ggaaataccg
     4441 aaagcgcggg ccaaaggaat ggctacggca taaccggctt gcgaaccgat acgtgctaaa
     4501 gcgacttgta cccccatagc cgtggcaagc tctttcccct taaaccactt ggctatgatt
     4561 ttggaaactg taataccggc gacctccgct cctactccaa aaatggaata accggcaaaa
     4621 gcaacaaaca cacccgtttt atagccaaat atttcattga ttccgaataa agtcgcgtcg
     4681 gcaccggcaa gtcccgtcat tgcatagtat tcaagtgctg taccacctac catcaggata
     4741 gttgccagct ttccggtgaa acggatacca aagcggtcga ggattaatcc tccccaaatc
     4801 aacatcagga aaaaaacatt cagaaaacta taaccaccgg taaagaatcc gaaatcggta
     4861 ctcgaccaag ccaagtccgt ttccaacatt gtcttcaacg gtgctaccac gtcgtttaca
     4921 taataagctg ccatcatcgt gaaggcaaca atcaccaatg ccccccaacg ggtagccttg
     4981 gaatcattca atttaagttt gagttgttct gtcattgtac tatttggatt tcaatttatt
     5041 aatcagattg cataaattgc tgacaaaggt aaataaatac ttcatcaaaa cgaaaaaagg
     5101 ctgacacctt ttcagtatca acctttctct tatttttcca agcgggagtc atccgcaata
     5161 tccttatctt attctgctgc aggggcttct gctgcaggag caggagcttc agccggagtt
     5221 gtagctgcag gggcctccga ttgcggagct tctgtaccta cgggcatgtt ataaggatta
     5281 gttttttctt cttgttgcgc ctgttccaga atcacatcac cgcccttgcc tgtggaagaa
     5341 ggaatagtgt aagcagaaac aatactgaag actaccatga cagctgccag agtccaggtt
     5401 gctttttcca aaaagtccgt agtcttgcgc acacccataa tttggttgga tgatgaaaag
     5461 cctgatgcca gaccacctcc tttagaattt tgaatcaata caatgaagca catcagcaca
     5521 gatgcaatca gcattaagat aactaataat aaatacattt tgttattttg atttagcgtt
     5581 aataatcaat ttctccaaaa atctgatttg gtctgcaaag taagcatttt tttttggata
     5641 attcaaactt aattttttaa taatttcaag cgccttgtca tatcggtgct gttttatata
     5701 gattttggct aaagtttccg taaaacagct atcgtccaac tcttccgtta ccggcgatac
     5761 tgagggttct tcctcttctt cagtctcttc ctccttctct acaagaaact cccttctcgt
     5821 atccgaggca tccgaagact cactcttttg gataaagtca tctatcaatt catgcccgcg
     5881 cagtttaggc acttccgact catcttctgc atccacaccg ggttcttcct gcattaaata
     5941 ggccgtataa tccaccgcat aatccagctc cgtatgctgt gaatgctctt cgggaacagt
     6001 agccagaaat gcgtcaatca aggaaagggt acggtccaca ctcggctctt tctccaaatc
     6061 gccggaaaac agcgacgaga ccttccggga tttcaaagta tagcggtcac cctctataaa
     6121 gtaaaacagc acacgacggt ctgccacata caacacagcc ttgcgcaact ccgcgccaaa
     6181 gttgatgtcg tgcagcagat agaggttttt cagatagagc aaacggagcg actggaaata
     6241 aggatagcgt gccaccaatg tgcgaagctc gtacaaagta tccctattca gcgtctcggg
     6301 atgctgaatc cattgttgca aatgggtagg cgtcatgagt ttaccagtta gctacagttg
     6361 cattgaaaat ctgttcggca atgtctttca ccatcaaggt tatcagctgg tcctgcactt
     6421 cggtcagcaa ttttgaggaa tcataggtct ggaaagccga gaactgctgt tcaaagtcct
     6481 cctcatggtt cgtgttattg gtgtagcgca cgttgacagt cagcgtcacc ttcaccttcg
     6541 aagagtagcc gctggcatcc accgattcat tatattgatt gtagccggtt atttctccgt
     6601 ctatttccag gtctcctccg gaattcacca gttgcaggcg agtctgctga atgaacatat
     6661 ccttcatttt ctggttaaat tctgttgcca gcggtgcata tacatactct gcccggttct
     6721 ggaaatcggc aatggaaatc gtttttacct ttgtatagtc gatagagctt atcggagcaa
     6781 gtcccaactt catactacat gaattcacca gaaataacaa gcttaccaac aaggaagcaa
     6841 atgccgcttt tttaatccaa tccatattct tttatctttc tgtataacgt acgctcagag
     6901 atattcaaat cctgagccgc actcttacgc ttgccgtgat gtttttcaag cgccttacgt
     6961 atcatttctt tctccacttc atccagggag agtgactcct ccacatattc ttccgtatcc
     7021 tggaaatcat cgtccaccgg agtaaccggc tttaccgaag gatgtataat ggtggggaca
     7081 ctggatgtta ccggaggtac caccgccgga gtagccggcg tatagtaggc cgatgtggca
     7141 accgccggat tggctaccgt tcccctttca gccataatct catgcaccaa ctttttcaag
     7201 tccgttacat cctggcgcat atcaaacaga acctggtaga gaatttcccg ttcactccca
     7261 aagctcttgt cctccttcac tccaaacaag gcaggcaggc gctgcatatt gttctgctca
     7321 ggcagatagc ccttcagtat ggatgcattg atttcacgat tggtctcaat gatggatatc
     7381 tgctcggtga tattcttcaa ctggcgcaca ttacccggcc atgagtagcc cagcaacact
     7441 tgcttgccgt cttccgtcag ctgaatggca ggcatacggt acttttctgc aaagtccgaa
     7501 gcaaactttc ggaacagcag caccacgtct tcaccgcgtt cgcgcaatgg agggacctga
     7561 ataggaactg tgttcaaacg gtaatacaag tcttcacgaa aacgtccgtc agcaatggct
     7621 tgtgtcaagt ttacattggt agcggcaaca atacgcacat cggtcttttc caccttagaa
     7681 gaacctactt tgatgaattc accgctctcg agcacacgca acaagcgtgc ctgggtaggc
     7741 aaaggcaatt cgccgacttc atcaaggaag attgttccgc cgttggcctc accgaaatac
     7801 cccttccgtt cgccgatagc cccggtaaat gcgcccttct catgaccgaa cagttccgag
     7861 tcaatcgtcc cttcgggaat ggctccacag ttcacggcaa tgtactgtcc atgcttgcgc
     7921 cggctgtact ggtgtattat ctgcggaaag ctctcctttc ccacaccact ctctccggta
     7981 atcagtacag acaagtcggt gggcgctacc tggatagcga tatcaatggc acgcatcagc
     8041 gcttcattgt tgccgataat gccgaaacgt aattttactt gttgtatttc cgcttttgtc
     8101 attctacaaa tcttcttcta cactatcgag tttcagtttg tcgctatcgt cacgtttctc
     8161 gtaatattgc ttgcgcagcg gatttgcatg tgcctctttc tcacgctggc ggttacggaa
     8221 cacatctatt gccacataga tagcctgccg gaatgaatct tcagaggcga ttcctttccc
     8281 ggcaatatcg taggccgtgc catgagcagg cgaagtgcgt atcaccggca agccggcagt
     8341 atagttcacg ccctcgtcca tagccaatgc cttgaacggt gccagcccct ggtcgtgata
     8401 catggccagg ataccatcaa aatgggtaaa gttatctgag cccataaacc cgtctgccgg
     8461 ataaggacca tagcaaagca tacccttagc agccatttcg ttgatggccg gaatgataat
     8521 ctcctgctct tcagttccca gcaatccgcc gtctcctgca tgcggattca gcgaaagcac
     8581 tgcaatacgc ggtgcgctga tagcaaaatc ctgcttcaag gagcggttga atatcttcag
     8641 tttttcttgt atcagttctt tggtgatgct tccggctatc tctttaacgg gaatatgtcc
     8701 ggtcaccaat gctacccgga agtcatcttt catcagaatc ataagggcct tctcgccatc
     8761 tcccaatttt tgctctatat actccgtatg tccggggaag gcaaactcct ccgactggat
     8821 ggtatgcttg ttgatgggag ctgtgacaat cacgtctatc attccctcct tatattcctc
     8881 aatggctttt tccagtgcac caagtgcagc tttaccagct tcaacgtcag gtttagagaa
     8941 ctcaaccttt acttcatcat ccgtacagtt cactacactc aagcgattgg gaaccgcttc
     9001 ggaggcggag ttgacgatac tgaagttggt aggcaagtcc aatgatttac gatgataagc
     9061 tgccacttta ggcgaaccgt agataatcgg cgtgcacaat tccagcatca ccgggtctgc
     9121 aaacgtcttt aaaatcactt cataccctac accattaatg tcgccttgtg taatgccgac
     9181 tcttattttg ttgtcttcca tttttattac ttattattag tagtatcttt tgaggttacg
     9241 cctaccggaa tttccgcacc ttcctgcttg ctgccgggca gtttcaaggt atagagcgaa
     9301 gcctccatct gacgtaccag attacgtttc attttatcag gtgaataaat aaatatttca
     9361 gatacgataa tacgctgatt ggccttgtcc aaacgtacat gcgatacgaa cggaccgccc
     9421 atgaggtcac cctttatgcg ccacaagccg cgggcctcca gtgcatagtc tccctgcaca
     9481 ctgatggggc gtacatcggt catcagagaa tccgtcgaca tatacatgcc ttcacgggca
     9541 ccagggatat taaccttcat cacggaatcg cgtttatgaa caaaatattc tttagtaaac
     9601 gtatccttat ccgtataagg ataagagtag attacaaagt tctggtcgcc ggtagctgca
     9661 ttcgtacctg cccagaagaa gttctcaccc tccttggtag atgtcagttc gcccggcacc
     9721 catacatcgc aatcgaactg gcttttcacc ttcgttgcta tatagtcgct atgcttgtcc
     9781 ttcaatactg aaatctgacg attcatttcc gcatgggtaa agaaatcgat gattacctgc
     9841 ctattctcct ccacaaattt ctcgaacgaa gcctcgtccg gtgcctgaat agtgagaata
     9901 gactgaggag cagcatatac attccttgca tacttgaatt taggctgggt atagaggtcc
     9961 ttgttcacat cgacaataat gatattgcga atcagtttta aagtggcatc ataattggaa
    10021 ggggcagtat acatgattcg gaatgaacgt tctgactggg gaagccccgg aacatcagaa
    10081 tcaagcacat cgaaaagcgc cctaccggca ggacgttccc acaagccggg ctccaccact
    10141 accagaactt catacgcacg accactggag gtcggagtaa acacaccctt tttaccacca
    10201 ccgcaagcgg aaaaaagtgt cagtacgaga accatactta aataaaacaa gtgctttctc
    10261 atatctctat cattttagtt tttcacaaag ctacgaagaa tgcgtaatat cctccctacc
    10321 taagttaata atttatatta attcttcttt attctcctcc tgcttggcag tggacaacat
    10381 gccacaagcg gcaaatatat cctctccacg cgatgaccgt atagtggtaa acagaccgtg
    10441 cgaagtcaga taatcacgga acgcagtcat ggtttccata tcagcccctt caagattcac
    10501 tccaggtatg gcatgaaaac gaatcaggtt aatccggcag tccagcccgc gtagcagctt
    10561 cagaagttcc tttgcatacg gtaacgagtc attcactcct ttgaaaacaa tatattcaaa
    10621 agatagtctg cgctgtttgc taaaatcata gtttcttaac aattccacaa tctccgtgat
    10681 ggagaacgcc ttctctgccg gcatcagttc gcggcgttgc aaaggtatcg gcgaatgaag
    10741 gctgatagcc agatggcagt ccgattcctc aataaaacgc tgcaagccct tcttcaatcc
    10801 cacagaagaa agtgtaacac gcttgggact ccacgcatac ccataagagg cggtcattat
    10861 ttccagcgct ttcaatacct cgtccagatt atcaagtggt tcacccatgc ccatcattac
    10921 cacattggta agcttgtccc tttcgggcaa cgaattgatt tgattaataa tctggttgga
    10981 tgtcagattg gcagtaaaac cttgtttgcc ggtcatacag aacttgcaat tcatcttaca
    11041 gcccacctgc gaggagacac aaagcgtagc cctgtcttcg tcgggtatat agacagcttc
    11101 cacgaaatgc ccctcgcctg cccggtacaa gtatttcacc gtaccgtcta cagagcgcat
    11161 ggcatctacc ggcgcttcgg cacctacctc atagatttct ttcagcaatt cccgatgctt
    11221 caacgaaaga ttgctcattt cgtctataga agtcaccttc ttgtcataca gccaggaagc
    11281 tatctgcttg gcagagaaac cgggcattcc cagattcttc accacattct gcaattcaga
    11341 gagcgtcaag cccaatagag gtcgtttctg catatcgttt ttcattaaaa acaaaactct
    11401 ttcaagaatg caaaggtagg aataaagttg cacaaagaca acggagagta tagaaaatga
    11461 aatgtacaga gaatgaaaaa gccgcccggg agtaccgaac ggcttttcaa tatgggtttt
    11521 ctattcttag aagaataaat aacgttggtc ttttacgttg gctttcagat acaagtcact
    11581 gatgaactgg cttgccatgc gtgcgtgcat gttagccaag ttagcctctt cagtttcctt
    11641 gttgaatgtt tcgttcagct tctcttttgc ataaggttgc agaacgaata caccaccgtt
    11701 acccttgata ggagcactca gcttgttcac ttcggcaata gaagcgtatg cgcctaccag
    11761 aggttcgctg ctacgcaatg ccgggatata ggcaggagca gagaaagtaa cgtgctttac
    11821 agaatcacta acagcatttg ccatattctt gtactgctcg aacgaagttg cattggcagc
    11881 cttcatatca gccataatct tctctgcttt cttgtcacgg agaatttcag ctctcaactg
    11941 gtcctttacc aaagccagtg gacgataacc ttcaggaaca atacttgcaa cacctactac
    12001 cagcatacgg tcgctctcgc cacattcgta caaaccggaa acttcaccgg cttttgcctc
    12061 aaacgcccat ttcaaagcat ctttggttcc tctgatacca ccgataccat gttcagagct
    12121 gtacaaatcg gctctatcca gcaacttgta accggcatct tccgcattgg caatcatttt
    12181 ctctaaagta ttgtttgcag cgatgaactg gctaaactca ttgtatgcct tgctgtaagt
    12241 ttccttgctg aattctaccg gacgcttgat aacggctacc ttatatttat ccttgacagc
    12301 cttcttgttg gttacttgca aaatgacatt tgcttgtccc aacgccagat tggtcagttc
    12361 gttctgtccc aaagttgtga cagcggtaat gtatttcaag ttgtcaccgt caatctgtgc
    12421 gccttcgtag ttagcagaag aaatccaggt aggctcaccg gtctgaccgt acttcttcgc
    12481 aacttcagca aagctggcac cacccttaat agcattgtag atgctgtcgg ccaaagtctt
    12541 cgtcttttca gcatcttcgg caactacctg aatctgacgg aactcgatag agtccggcat
    12601 ggcagcagta gccaatttct tgaaagagtt gagggtattg tcagatacgt tataataagg
    12661 cccgaacaca ccacccaccg caacagagtc caaacgggct gtcacatcag caggcagaga
    12721 cttagtagtg tagaacaagt ctgtataagg agcttcggaa ccggtagaac ggatgaaggt
    12781 agtatagtca gaaggattgg cagtaagttg ttcggtgtat tcttccattt ccttctggag
    12841 agcagctctg tcttctgcac ttgcagtaac ttgcacatca atgaacttga tattgcgagt
    12901 ttccacatat tgcttgaact gttctttctt cttgtcgtat gcagctttca aatcggaatc
    12961 cttgataacg atggtagagt caacgataga agaataggga actgcagcaa gcagcaggtc
    13021 tgactgctct actcttgcat caaaagcgtc ctgagcttct accgggttgg agaaaagaga
    13081 ttttgtaatc aaagcctgat acttctcctg aagacgtgcc tggataaggg acttttcgag
    13141 gaaagaccag aacttgtaca tggattcata gtattctgca tattgtgaag gcatctgtgc
    13201 cttattcatt tttgaatagt ccaccaagaa cttcttcaac atatccttat caaacgcacc
    13261 ggtctgagga ttacggaacg gagtctgttg cagcatcgga tgcacaccgg cattaatgat
    13321 agcctgaatc tcagccttcg atacaaccag accgagtttc tttgcttcct tttcaatcag
    13381 cttattattg acgtatgttc tccatacttc atctttgatt tggtttgtct gctcatcgct
    13441 caatgcactg ttgccactgg agaacttgat gacttctgta tattcttcta ccaatgcttg
    13501 aaaatcctga gcggaaattg attccccgtt cacttcacct acgtcttgtg actggtgtgg
    13561 ctgaagcact ttccacgcgt cacctgcgat gaaagcaaac agcg
//
