LOCUS       c00043_gnlPro..        13550 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|NPLAGMNC_43.
ACCESSION   c00043_gnlPro..
VERSION     c00043_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 02:28:19
            Original ID  :: gnl|Prokka|NPLAGMNC_43
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 14006
            Orig. end    :: 27556
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13550
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[24006:27554]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..13548
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..13550
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13550
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             585..1232
                     /locus_tag="ctg43_19"
                     /transl_table=11
                     /translation="VLPEYNRDVILSIRHFIVENVRTARRFLKKTEPSIVIDDLVFSEL
                     NKHTSPEEVTGYLAPLAKGESVGVISEAGCPAVADPGADVVAIAQRKGYKVVPLVGPSS
                     ILMSVMGSGFNGQSFAFHGYLPIDASQRTNAIKKLEGRIYSENQTQLFIETPYRNNKLA
                     EELIRTCRPSTKLCIASNITCEDEYIHTRPVKEWAGKVPDLSKKPTIFLIYK"
     CDS             complement(1464..1715)
                     /locus_tag="ctg43_20"
                     /transl_table=11
                     /translation="MPVFAHPTDLTGRIADNQSVWRNIFSDHGPCADHSIFADRMAAND
                     RCIRTNRSSFADMCFQILVFTGNGTAGIDHICKNAAGS"
     CDS             complement(1836..2579)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) QRPTase_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) QRPTase_N"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg43_21"
                     /sec_met_domain="QRPTase_C (E-value: 2e-61, bitscore:
                     198.1, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="QRPTase_N (E-value: 8.4e-24, bitscore:
                     75.0, seeds: 125, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGKSQLIVKEDGVLAGVEMAERIFHTFDPELKMTTFIHDGAEVKK
                     GDIAFVVEGKVQSLLQTERLMLNVMQRMSGIATTTRKYVKALEGTKTRVLDTRKTTPGL
                     RMVEKEAVKIGGGVNHRIGLFDMILLKDNHVDFAGGIEAAITRCHQYLKEKNKDLKIEI
                     EVRNFDELQEAMRVGGIDRIMLDNFNIENTKKAVEMVAGRYELESSGGITFATLRDYAE
                     CGVDYISVGALTHSVKGLDMSFKAC"
     CDS             complement(2761..3132)
                     /locus_tag="ctg43_22"
                     /transl_table=11
                     /translation="MKRLFLTLALVLSVLSVMAADIVPISNAFKRGNVSSLSGSMDKEV
                     DMALPGSSKKCNANDAVSMLNAFFGGNKPTGFTVVHHADKKETGFFVGKLPTSSGEYRV
                     NVTYRAEGNKAIIQSIRIE"
     CDS             3223..3696
                     /locus_tag="ctg43_23"
                     /transl_table=11
                     /translation="MKIALIVIGKTDAGYFVEAINEYKNRLVHYIPFEMEVIPDIKNVK
                     NLSESQQKEKEGDLILKALQPGDYLVLLDEKGKEFTSVQFSTYIERKTHTVPKRLVFVV
                     GGPYGFSDAVYKAAAEKISLSKMTFSHQMIRLIFIEQLYRAMTILNNEPYHHE"
     CDS             complement(3765..4133)
                     /locus_tag="ctg43_24"
                     /transl_table=11
                     /translation="MLTINAVKGFEYGDGFEAALYRGSERNDRFFNDNGHINTHTNHSG
                     GIQGGISNGQDIYFRVAFKSVATILMEQETVNTEGEDTILKARGRHDPCVLPRAVPIVE
                     SMAAMTLLDFLLMQKIRN"
     CDS             4137..4343
                     /locus_tag="ctg43_25"
                     /transl_table=11
                     /translation="MSQCRMQLSEYRFAQTNGNSLCYAGDYAADRISFGFHFGDQSLHF
                     FGGRRVRTTYGRIFRLVQVVIRV"
     CDS             4383..4736
                     /locus_tag="ctg43_26"
                     /transl_table=11
                     /translation="LYPDTFLAKNQFGNCSGYATGDRFTCRRTSTSARVADSVFGLVGV
                     ICMGRTINILHIIVVRRVLVLVPDDETDRSPCRFSFVNTGKELYFVVFLAWGCDFGLSR
                     FTAVQFTLDKCRI"
     CDS             4724..5449
                     /locus_tag="ctg43_27"
                     /transl_table=11
                     /translation="MPYLVRYQQGIRLLRLRFRDRATLRKRSACICFQMYSPLLKLSIV
                     NSLMASATSASTFVVMVATTASAVVTSTTASTSRSCEGCDFFSCRFVYIDNFTIEMQCF
                     ASQRMVEVHNDNIFFYFQDRTVHAVAVRIHHRYRVAFFDHFRVELAVYLENILRKIQYV
                     FLHIFAVCISRSYGKIKFVAYFQSFQSVFKSGEHSACTKDEFQRCFSCCSFHQFAFFAF
                     AYIQIVSNCNELICCNFHL"
     CDS             complement(5541..6791)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg43_28"
                     /sec_met_domain="Aminotran_1_2 (E-value: 2.6e-41, bitscore:
                     133.4, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSESKQFLNIIRIFDPDQQTELIEIMKQYNFDEIIERRGTNCVKY
                     DLLKKDFGNENLVPLWVADMDFRTPDFIVNAIKKRLEHEIFGYTFDSDSYYNSIIEWVH
                     YKHNWKIQREWLSYIPGIVKGIGFVLQCFTKPGDKVIIQPPVYHPFRIVPENMHREVVY
                     NPLKTVDDIYEMDFENLESVIDEHCKVLILCNPHNPGGVVWKKDTLVKLAEVCAKHNIL
                     VISDEIHAEMAYPQYTHHPFATVSETAANCSITFMAPSKTFNIAGIVTSYSIIPNAEIR
                     EKFYSFMEAGEFNAGTIFAYTATEAAYTYGAEWLQQMRMYITENVRFVDEYCKSKLPKI
                     KVYPPQASFLVWLDCRDLKLSQPELVSLFQDKAGLLLNDGSMFGPGGEGHMRLNIGCPR
                     SVLSSALDALKKAIDKK"
     CDS             complement(6816..7037)
                     /locus_tag="ctg43_29"
                     /transl_table=11
                     /translation="LPNGKSLFDLGQKDIRRRSKALWLYSLTIKVWQLPLYDTFRTRLI
                     YKCQLFTFIDTYNRIFNTQSIYFRTRQN"
     CDS             complement(7390..7509)
                     /locus_tag="ctg43_30"
                     /transl_table=11
                     /translation="MTSQFLAHLSPYLLMTRRTTTRIICNTLFIIFSYIFIIV"
     CDS             complement(7523..7744)
                     /locus_tag="ctg43_31"
                     /transl_table=11
                     /translation="MAIIGLPNCSSFRPLARHKARAPAMRLPSVLYELLNGFFIILFVV
                     FERLTNRPYFLILNIIILKKPFSVWRKA"
     CDS             complement(7752..7961)
                     /locus_tag="ctg43_32"
                     /transl_table=11
                     /translation="VGIHHILDAVRNNITRRKRIEHSVVSHSDTIVNSNRIEFGSKATQ
                     LFNLRFYLLPDLVQMDMAGYKLGK"
     CDS             complement(8016..8291)
                     /locus_tag="ctg43_33"
                     /transl_table=11
                     /translation="MRSDDRPVARKCQTDRFVQTVHRVGRKHTGTTTASRTGIPFHLCD
                     PFIADRSVGRFDHGIDQIQMAVIQLTGFHRTAGDKDSRNIEPHGCH"
     CDS             complement(8284..8427)
                     /locus_tag="ctg43_34"
                     /transl_table=11
                     /translation="MTWHSGKPDGWRYCGEEQTHHRHDSIYRHFLQSAGQHRGTVAYGP
                     HA"
     CDS             complement(8424..9128)
                     /locus_tag="ctg43_35"
                     /transl_table=11
                     /translation="MTAFYIRSRIKHFLHTRTTLRSFVCDHHHIARDDFSTEDAFASRI
                     LRIEHFRRTGKLPDAFIHTGRLDHTTVQRDISFQDSQAAIFGISMLDITDTSGGTIGIQ
                     FLIIGFLRSHPNAETMGGSTLVFLDSLVRHIRRGDSKFIYGFGKRHTVHTLHIPVYQAA
                     FQQLVHDSHDTTGTVHILDVVGVRVGSNLAEARSLAGEHIDIVHREVRLSFLRDGEQVE
                     NRIGGTTHCNIQ"
     CDS             complement(9129..9371)
                     /locus_tag="ctg43_36"
                     /transl_table=11
                     /translation="MRRRKGFCAAGFFRFTAFCQLFIAYLHINRTFRDINLDYIAVFHQ
                     SNRSSCRSFGRNMTDRKTGSTATETTVCDQRALLA"
     CDS             complement(9387..9530)
                     /locus_tag="ctg43_37"
                     /transl_table=11
                     /translation="VTSAKLPNRLSSVSPYLFILVLCLIFYYSHSTLIGRTDHLTVSSQ
                     GF"
     CDS             complement(9527..9643)
                     /locus_tag="ctg43_38"
                     /transl_table=11
                     /translation="MTHQYMLQFIPVIVQTIVNRNRLPAGITENRIYSFSYQ"
     CDS             10001..11185
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg43_39"
                     /sec_met_domain="TPP_enzyme_C (E-value: 2.8e-51, bitscore:
                     164.8, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VDYEYKKVDYIRSYQPEPDINQDRIKAAAALINKAEKPFCLVGQG
                     VLLGGAEEELKAFLLKNDIPAGSTVLGLSALPSDFPLNKGMLGMHGNVGPNRKTNECDV
                     LIAIGMRFDDRVTGDLKTYAKQAKVIHLDIDNSEIGKNVPVDVKVLGNAKHTIPMITAL
                     LEERKRPEWNAEFELDAQEEYEKVIEKELYPMNGSLKMGEVVRKVSEATGNDAVLVTDV
                     GQNQMMGVRYFKYKRTRSVVTSGGLGTMGFGLPAAMGAKFGAPDRTVCFFTGDGGMQMT
                     IQELGTIMQEKLDVKIIILNNNFLGMVRQWQELFFHERYSNTIMENPDFVAIAKAYGIA
                     GRTVEKREELDEAIAEMLNHNGAFVLVANVETCGMVYPMVPAGGSVTNMILGDK"
     CDS             11198..11749
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg43_40"
                     /sec_met_domain="ALS_ss_C (E-value: 3.2e-17, bitscore:
                     54.1, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTKKLYTVIIFSENTVGLLNQITIIFTRRQLNIETLSVSPSAIQ
                     GIHKFTITTFADEDMIDKVVKQIDKRVDILKAYYNTDEDLVFQEIALYKLSTELFIKMG
                     TVEDLIRKYNARILEMNETCVVLEKSGHYDETQALFRELSETIGVLQFIRSGRIAITKS
                     RVERLSDMLAEMERKLQEKK"
     CDS             11757..12527
                     /locus_tag="ctg43_41"
                     /transl_table=11
                     /translation="VVCELPQQKRIMDKDKSKIGEFHFVTEPYLLDFRGRVTIPMIGNY
                     LIHVASSHAAERGFGFNDMSERHTAWVLSRLAIEMIEYPAMSEPITLYTWVDEVGRLFT
                     SRCFELVDGNGKTFGYARSIWAAIDVETRRPTLLDIARLSAYVTDRPCPIEKPGKIAAV
                     ENETEGVPYFIKYSDLDINGHLNSIKYMEHLLDLFDLDLFKTKDIKRFEIAYQSEGKYG
                     MKLMLYKREADNGKYDMAICNEGKAICRAAVMWH"
     CDS             complement(12598..12981)
                     /locus_tag="ctg43_42"
                     /transl_table=11
                     /translation="MREIQRFSRSQIFFDTRPAFDLSGVGKQHLYDSCSFASFFNTEQC
                     FTRYPAVGNSFVIGFTRALSYDNVETIITQVQALSRTLNTVTDNCNHFIFQYFSCLFQR
                     KFFAGYYVFVNTAKIHYCHFFYY"
     CDS             13159..13548
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg43_43"
                     /sec_met_domain="IlvC (E-value: 2.3e-39, bitscore: 126.5,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VIALGIGVGSGYLFETTFKKEVYSDLTGERGTLMGAIQGLLLAQY
                     ETLRENGHEPSEAFNETVEELTQSLMPLFAENGMDWMYANCSTTAQRGALDWMGPFHDA
                     VKPVFEKLYREVACGNEAQRSIDTNS"
ORIGIN
        1 cgcaattcgg atttccccac ttggcgatat tttccgccag gatatgactc cggctacgga
       61 tcacctcatt gctgaccagc aggctccctt ccggcagaca agccgccagg tgagtcgatt
      121 tgcctcccgg agcggcgcag aggtcgaggc atcggacagg cgttttcacg tggctgcgga
      181 tcacttgttc gagaaacatg gacgacgctt cctgcacgta gtaggcgccg gcatggaaga
      241 gcgggtcgaa ggtaaacgaa agcctttcag gcaggtaata acctgtatcg caccacgcca
      301 cccggttatc cggagtatcg gctgccggga taggagcgcc tttcttctcg ttgatacgga
      361 tgctgacggg gacatcggcc tgcaacgccg cttcgaaact gtcgaactca tttcccagca
      421 atgcgcgggt acgtgtgata aaatctatcg gaagtgccat ctcttttcgc ttgttttcgg
      481 caaaaatact acttttgcgt aatcaattat caattgtcta ttaaaaaagt atgtccgctc
      541 tttacctcat tcccgtcacg cttggcgacg ttgaacatcg ccgggtgctt cccgaatata
      601 accgggatgt tatcctttcc atccgtcatt tcattgttga aaatgtgcgt acggcacgcc
      661 gtttcctgaa aaagacagaa ccctctatcg tgatagacga tcttgtcttt tctgaactga
      721 acaagcatac gtcgcctgaa gaggttaccg gctatctggc ccctttggcc aaaggcgagt
      781 cggtcggcgt gatctcggag gccggctgtc cggctgttgc tgatccgggt gcggatgtgg
      841 tggctattgc acagcgtaaa ggttacaagg tggttccgct ggtcggccct tcttcgatcc
      901 tgatgtcggt gatgggttcc ggttttaacg ggcagagctt tgcttttcat ggctatctgc
      961 cgatcgatgc ttcacagcgt acgaatgcga tcaagaagct ggaagggcgc atctactcgg
     1021 agaaccagac gcaactgttc atcgaaacgc cttaccgcaa taataaattg gcggaggagt
     1081 tgatccgtac gtgccgccct tcgaccaaat tgtgtattgc ttcgaatatc acttgcgaag
     1141 atgaatatat ccatacgcgt cctgttaaag aatgggccgg aaaggttcct gatttgagca
     1201 agaaaccaac aatcttctta atatataagt aaatggaaac ttataaggca catgaaacag
     1261 ccgttatcga tcccggatgc acgattggag acggcacaca catctggcat ttttcccata
     1321 ttatgccggg atgctcaatc ggtcggaatt gcaatatcgg acagaatgtc gtgatctctc
     1381 ctctggtggt tttagggaat aatgtgaagg tacaaaacaa tgtctccgtc tataccggcg
     1441 tgacttgtgg ggatgatgtt tttttaggac ccagctgcgt ttttacaaat gtggtcaatc
     1501 cccgcagtgc cgtttcccgt aaagaccaat atttgaaaac acatgtcggc aaaggagctt
     1561 ctattggtgc gaatgcaacg atcgtttgcg gccatacgat cggcgaatat gctatgatcg
     1621 gcgcaggggc cgtggtcact aaagatattc cgccatacgc tttggttgtc ggcaatcctt
     1681 cccgtcagat cggttgggtg agcgaatacg ggcatcgcct ctccttcaat gaaaaaggta
     1741 tcgccacatg cccggaaagc aatcagcaat acctgttaga ggggggcgtc gtgacgcgta
     1801 tttcgtagag acgagatccg cccgccttaa tgtctttagc aagccttaaa gctcatatcc
     1861 agccccttga cagagtgtgt cagggctccg actgagatat aatccacacc gcattcggca
     1921 taatcgcgaa gcgtggcgaa tgtgatgcca cctgaagatt ccagctcgta acgtccggca
     1981 accatttcga cggctttctt cgtattctcg atattgaagt tgtccagcat gatacggtcg
     2041 ataccgccga cacgcattgc ttcctgtaac tcgtcgaagt tacgaacctc gatttcaatc
     2101 ttcaaatcct tgtttttctc tttcagatac tgatggcagc gtgtgatggc cgcttcgata
     2161 ccgccggcaa agtccacatg gttgtctttc agcaaaatca tatcgaacaa cccgatacga
     2221 tggttgacac cgccaccgat tttaaccgct tctttctcga ccatacgcag acccggagtc
     2281 gtcttacgcg tatctaacac gcgtgttttc gttccttcca gagccttgac atatttgcgt
     2341 gtcgtggtgg caataccgct catgcgttgc atgacgttga gcatcaagcg ttccgtttgc
     2401 aacaaagact gtaccttccc ttcgacaacg aaagcgatat cgcctttctt cacttcggct
     2461 ccgtcatgga tgaatgtcgt cattttcagc tccggatcga atgtgtggaa aatacgttca
     2521 gccatttcga caccggccaa tacgccgtct tctttcacga tcagctggct cttccccatt
     2581 tccgtagccg gaatgcaaca taaagtcgta tggtcgccat ctcctatatc ttctgcgaat
     2641 gccaggcgga tcagttccgc aatcagttgt tcttttgtct cttgtacgtt catgttactg
     2701 ttgatttatg atttatgatt tatgatttat atgcgacaag gtataaatca taagatcttg
     2761 ttattcaatt ctgatagact gtataatcgc tttgtttcct tctgcacggt atgtcacgtt
     2821 tacgcgatat tcaccggatg aagtaggtag tttaccgaca aagaaaccag tctctttttt
     2881 atcagcatgg tgaacgactg tgaatcctgt cggcttgttc cctccgaaga aggcattcag
     2941 cattgaaaca gcgtcgtttg cgttgcactt tttggatgaa cccggtaggg ccatgtcgac
     3001 ttccttgtcc attgatccac tgagcgacga gacgttgcct cttttaaaag cgttcgatat
     3061 aggaactatg tcggcagcca ttacactcag aaccgagaga accaatgcca acgttaaaaa
     3121 taatcgtttc ataagctttc tcctcttttt gtgagtatta tcgtacaaag gtatgtattt
     3181 tttcctgtaa tttagcaccc tcaatctcta aaatgtaaac gaatgaaaat tgcgctgatt
     3241 gtgatcggca agacggatgc cggctatttt gtggaagcga tcaatgagta taagaaccgc
     3301 ctagtccatt atatcccttt tgaaatggaa gtgattcctg atattaagaa cgtcaaaaat
     3361 ctttccgaat cccaacaaaa agagaaggaa ggagatttga ttctgaaagc attacagccg
     3421 ggtgactatt tggttttgtt ggatgaaaaa ggaaaagaat ttacatcggt gcagttttcc
     3481 acctatatag aaagaaagac gcatacagtc ccgaagcgct tggtttttgt tgtcggtggt
     3541 ccgtatggtt tcagcgatgc tgtttataaa gccgccgccg agaaaatatc cttaagcaaa
     3601 atgactttct cccaccagat gatccgcctg atctttatcg agcagctcta tagggcgatg
     3661 acaattctga ataatgaacc ctatcaccat gaataattgg caattgacaa ttaaaaatac
     3721 aatctgataa ttgtctgata catttaattg tcaattgtca attctcaatt tcggattttc
     3781 tgcataagca gaaaatccaa cagtgtcatt gctgccattg attcgacgat agggacagct
     3841 cgaggtaaaa cacacggatc atggcgtccg cgggctttca ggatcgtgtc ttcaccttcc
     3901 gtattgacgg tttcctgttc catcaggata gtggcgaccg atttgaaggc aacacggaaa
     3961 taaatatcct gcccgttcga gatacctccc tgtatgccac cggaatgatt cgtatgggtg
     4021 ttgatgtgtc cgttgtcgtt gaagaaacgg tcgttccgtt ccgagccacg atataaggcc
     4081 gcttcgaaac cgtcaccgta ttcgaaccct tttacggcat tgattgtcaa catcgcatgt
     4141 cccaatgccg catgcaactt tccgaatacc ggttcgccca gaccaatggg aactccctgt
     4201 gctacgcagg tgattacgcc gccgatcgta tctcctttgg atttcacttc ggcgatcaaa
     4261 gcctccattt tttcggcggt cgccgggtcc ggacaacgta cggccgtatc ttccgccttg
     4321 tccaagtcgt aatccgtgta tgagccgtta agtttgatgt tcccgacctg tgaggtaaat
     4381 gcttgtatcc ggataccttt ctggcgaaga accagtttgg caattgctcc ggctacgcaa
     4441 cgggcgatcg tttcacgtgc agacgaacgt ccacctccgc gcgggtcgcg gattccgtat
     4501 ttggtctggt aggtgtaatc tgcatgggaa ggacgataaa cattcttcat attatcgtag
     4561 tccgccgagt gctggttctt gttccagatg atgaaaccga tcggagtccc tgtcgttttt
     4621 ccttcgtaaa taccggaaag gaactgtact tcgtcgtctt ccttgcgtgg ggttgtgatt
     4681 ttggactgtc ccggtttacg gcggttcagt tcactttgga taaatgccgt atctagttcg
     4741 ataccagcag ggcatccgtc tattacgcct ccgattccgg gaccgtgcga ctctccgaaa
     4801 gaggtcagcc tgtatatgtt tccaaatgta ttcacccttg ctaaaattgt caattgtcaa
     4861 ttctttaatg gcatccgcca catccgcatc caccttcgtg gttatggtcg ccacaaccgc
     4921 ttccgcagtc gtcacatcca caaccgcatc caccagccgg agctgtgagg gctgcgattt
     4981 cttcagctgt cggttcgtgt acatcgataa cttcaccatt gaaatgcaat gtttcgccag
     5041 ccaacggatg gttgaagtcc ataacgacaa catcttcttt tacttccaag acagaaccgt
     5101 tcatgcggtt gccgttcgaa tccatcatcg gtaccgtgtt gccttctttg atcatttccg
     5161 agtcgaactt gccgtctacc tcgaaaatat tcttcggaag atccagtacg tgttcctcca
     5221 catattcgcc gtatgcatca gccggagtta tggaaaaatt aaatttgtcg cctacttcca
     5281 gtcctttcag agcgtcttca aaagcgggga gcatagcgcc tgtaccaaag atgaatttca
     5341 gaggtgtttc agctgttgct ctttccatca attcgcgttc ttcgccttcg cctacattca
     5401 gatcgtaagt aactgcaacg aacttatttg ctgtaatttt catttgtaat tgtatttgtg
     5461 ataaataaaa tggtgacaaa tttacgtata atttccgact tgtctgccca atctctggat
     5521 aattaaacag gcaaacggct ttatttctta tctatcgctt ttttcaaagc atccagtgcg
     5581 gaagacagga cggaacgcgg acagccgata ttcaaacgca tatgcccttc acctccggga
     5641 ccgaacatgc ttccgtcgtt cagcaacagg ccggctttat cttggaacaa gcttaccagt
     5701 tcaggctggc ttagtttcag gtcacggcaa tccaaccata caaggaaaga tgcctgaggg
     5761 ggatagactt tgatcttcgg gagtttggat ttgcaatatt catctacgaa gcggacattc
     5821 tcagtgatat acatccgcat ctgttgcaac cattcggctc cgtatgtata agccgcttct
     5881 gttgccgtat aggcaaagat cgtcccggca ttgaattctc ctgcttccat gaaggaatag
     5941 aacttttcgc gtatttccgc attgggaatg atcgagtagg aggtgacgat tccggcaatg
     6001 ttgaaagtct tgctcggagc catgaaagta atgctgcaat tggcggctgt ctccgaaacc
     6061 gttgcaaacg gatgatgcgt atattgcgga taagccatct ctgcatgtat ttcatcggag
     6121 ataacgagta tattgtgttt ggcacaaacc tcggccaact tgaccagtgt gtcttttttc
     6181 cagacgacac cgcctggatt atgagggttg caaaggatca ggaccttgca atgctcatca
     6241 atgaccgatt cgagattctc gaaatccatc tcgtaaatgt cgtctactgt tttaagcggg
     6301 ttgtagacaa cctcacggtg catgttttcc ggaacgatgc ggaagggatg gtagaccggt
     6361 ggctggataa ttactttgtc accaggtttg gtgaagcatt gcaaaacgaa accgattccc
     6421 tttacgatgc cgggaatata actaagccat tcgcgttgga ttttccagtt atgtttataa
     6481 tgtacccact cgatgatact gttataatag gaatccgaat cgaatgtgta cccgaaaatc
     6541 tcatgctcca gacgtttctt gattgcgttg acaataaagt ctggtgtccg gaaatccatg
     6601 tcggctaccc aaagtggaac aaggttctcg ttaccgaagt ctttctttag aagatcgtac
     6661 ttgacacaat tggttccacg acgttcgatg atctcgtcaa agttgtattg tttcattatc
     6721 tctataagtt cagtctgttg atcggggtca aagatacgaa ttatatttag aaactgtttc
     6781 gattccgaca tttgggtagt tacacaaccg gacttttaat tttgtctcgt cctgaaatag
     6841 attgactgtg tattaaaaat cctgttatag gtgtctataa atgtaaataa ctgacacttg
     6901 taaatgagtc gggtacgaaa agtatcatag agtggcaact gccatacttt tatcgttagg
     6961 ctataaagcc atagagcttt tgacctacgt cgaatatctt tttgcccaag gtcgaaaagg
     7021 cttttgccat taggcaaaaa ggctttcggc cttgggcaaa aacgtaagaa gttataatta
     7081 aatctgtacg agacagggtg aaagcagatc tttaaggtga agccagtccg aatgcctgcc
     7141 tttaccttaa ggatctgctt ttattttaat atatagcaag acgatggtga agcctactcg
     7201 catattcttt catatgaaaa gttaggcgga aacaatccag acaggtattt cggatttgat
     7261 aatggaagat tggaaggatg tgttaaactg caagcctatc ttgtttcttt gcttgagaaa
     7321 tgtaagataa attgatattt ttcttttaat ttctttggtg gtatgaatta ttgttctaca
     7381 tttgcagcat caaacaataa taaagatgta agaaaagatg atgaacaatg tattgcatat
     7441 tattctcgtg gtggtccttc tagtcattag caggtaagga gaaaggtgtg caagaaattg
     7501 tgaagtcata taaagatatt tcttaagcct ttctccatac agagaagggc ttttttaata
     7561 taataatatt taggataaga aaataggggc ggttcgtgag ccgttcgaaa acaacaaata
     7621 atatgatgaa gaatccgtta agaagttcat acagcacaga gggcagacgc atggctgggg
     7681 ctcgcgcttt gtggcgtgcc aacggtctga aagaagagca gttcggtaaa ccgattatag
     7741 ccattgtgaa ttcatttacc cagtttgtac ccggccatgt ccatctgcac gagatcgggc
     7801 agcaggtaaa agcggagatt gaaaagttgg gttgctttgc tgccgaattc aatacgattg
     7861 ctattgacga tggtatcgct atgggacacg acggaatgct ctattcgctt ccttcgcgtg
     7921 atattattgc ggacagcgtc gagtatatgg tgaatgccca caaagccgat gcaatggttt
     7981 gcattagcaa ttgcgacaag atcactccgg ggatgctaat ggcatccatg cggctcaata
     8041 ttccgactat ctttgtctcc ggcggtccga tggaagccgg tgagctggat aaccgccatc
     8101 tggatttgat cgatgccatg atcgaatcgg ccgacacttc ggtcagcgat gaacggatcg
     8161 cacaggtgga acggaatgcc tgtccgggat gcggttgttg ttccggtatg tttacggcca
     8221 actcgatgaa ctgtctgaac gaagcgatcg gtttggcact tccgggcaac gggacgatcg
     8281 tcgctacgca tgtgggccgt acgcaactgt tccgcgatgc tgcccggcag attgtagaaa
     8341 atgcctataa atactatcgt gacggtgatg agtctgttct tccccgcagt atcgccaccc
     8401 gtcaggcttt cctgaatgcc atgtcattgg atattgcaat gggtggttcc accaatacgg
     8461 ttctccactt gctcgccatc gcgcaggaag ctgaggcgga cttcacgatg gacgatatcg
     8521 atatgctctc ccgcaagact ccttgcctct gcaaggttgc tcccaacacg cacacctacc
     8581 acgtccagga tgtgaaccgt gccggtggta tcatgggaat catgaacgag ctgctgaaaa
     8641 gcggcttggt agacgggaat gtgaagcgtg tggacggtat gacgcttgcc gaagccgtag
     8701 ataaatttgc tatcacctcg ccgaatatga cggacgaggc tgtcaagaaa tacaagagtg
     8761 ctcccgccca tcgtttcagc attcggatgg gatcgcagga aacctattat aaggaactgg
     8821 ataccgatcg tgccgccgga tgtatccgtg atatcgagca tgcttattcc aaagatggcg
     8881 gcctggctgt cctgaaagga aatatcgcgc tggacggttg tgtggtcaag acggccggtg
     8941 tggatgaaag catctggaag tttgccggtc cggcgaaagt gttcgattcg caggatgcgg
     9001 cttgcgaagg catcctcggt ggaaaagtcg tctcgggcga tgtggtggtg atcacacacg
     9061 aaggaccgaa gggtggtccg ggtatgcagg aaatgcttta tcctacttct tatataaaaa
     9121 gccgtcattt aggcaaggag tgcgcgctga tcacagacgg tcgtttcagt ggcggtactt
     9181 ccggtctttc tatcggtcat atttctcccg aagctgcggc aggaggagcg attggactgg
     9241 tgaaagacgg cgatataatc gagattgata tccctgaacg tacgattaat gtgaaggtaa
     9301 gcgatgaaga gttggcagaa cgccgtaaag cggaagaagc ccgcggcaca aaagccttta
     9361 cgccgcctca tcgccagcgt gtcgtctcaa aagccttgag agcttacggt aagatggtca
     9421 gttcggccga taagggtgga gtgagagtag tagaagatta aacacaagac taaaataaag
     9481 agatatggag aaacagaaga taaccggttc ggaagctttg ctgaagtcac tgatagctga
     9541 aggagtagat acgattttcg gttatcccgg cgggcaagcg attcctattt acgatagttt
     9601 gtacgattac agggataaat tgaagcatgt attggtgcgt catgaacaag gggcgacgca
     9661 tgctgcacaa gggtatgccc gtgtatccgg taaagtaggg gtgacgttgg ttacttcagg
     9721 acccggcgca acaaatacca tcaccggcat tgccgatgca ctgatggaca gcactcctat
     9781 ggtggtcata gccggacagg tcccttctcc attgcttgga acagatgctt tccaggaagt
     9841 cgatgtgatc ggcattacgc aaccgatcac caaatgggcg taccagattc gcaagccgga
     9901 agagatagcg tgggctgttt cacgtgcttt ttatatcgct tctaccggac ggccggggcc
     9961 tgttgtactc gatttggcaa aggatgctca ggttggattt gtggattatg aatataagaa
    10021 agtagactat atccgcagct atcagccgga accggatatc aaccaggatc ggattaaagc
    10081 ggctgccgcg ttgatcaata aagcggagaa accgttctgc ctggtcggac agggggtttt
    10141 gttgggaggt gctgaagagg agctgaaagc attcctgctg aagaatgaca ttcctgccgg
    10201 ttcgactgtt ctcggtctat cggcgttgcc ttccgatttt cctttgaata agggtatgtt
    10261 gggtatgcac ggcaatgtcg gtccgaatag gaagaccaat gaatgtgacg tgttgatcgc
    10321 catcggtatg cgtttcgacg atcgtgttac tggcgatttg aagacatacg ccaagcaggc
    10381 gaaagtgatc catttggata tcgacaactc ggagatcggg aagaatgtac cggtcgatgt
    10441 gaaggttctc ggaaatgcca aacataccat tccgatgata actgcgttgt tggaagaacg
    10501 gaaacgtccg gagtggaatg ctgagtttga gctggatgca caggaagagt atgaaaaggt
    10561 gatcgagaag gagttgtatc cgatgaacgg atctttgaaa atgggtgaag tcgttcgaaa
    10621 agtgtccgag gcgactggaa acgatgctgt tttagttacg gatgtcggac agaaccagat
    10681 gatgggtgtc cgctatttca aatataaacg cactcgtagc gtggttactt caggtggtct
    10741 ggggacgatg ggctttggcc ttcccgctgc tatgggagcc aagttcggtg cacctgaccg
    10801 tacggtctgc ttctttaccg gtgacggtgg gatgcagatg acgattcagg agttgggaac
    10861 cattatgcag gaaaaactgg atgtgaaaat catcatcctt aataataatt tcttaggaat
    10921 ggtacgtcag tggcaggagt tgttcttcca cgaacgttat tcgaatacga tcatggagaa
    10981 cccggatttc gtggcgatcg cgaaagcgta cggtatcgct ggccgcaccg ttgaaaaacg
    11041 ggaggaactg gatgaggcta ttgccgagat gttgaaccat aacggagcgt ttgtgttggt
    11101 cgccaatgtg gaaacgtgtg gtatggtata tccgatggtt cctgctggag gaagcgtaac
    11161 gaatatgata ttaggagata agtaaggagg tgaagctatg acaactaaaa aattatatac
    11221 cgttattatc ttttcagaga atacagtagg tcttctgaac cagattacga ttatctttac
    11281 gcgtcggcag ttgaacatcg agacgctttc cgtttcacct tccgccatac agggtataca
    11341 taaatttacg atcacgacat ttgccgatga agatatgatc gacaaggttg tgaagcagat
    11401 cgacaaacgg gtggatatct tgaaggctta ctataatacg gatgaagatc tggttttcca
    11461 ggagatcgcc ctttataagc tgagcaccga gctgtttatc aagatgggga cggtcgagga
    11521 tctgattcgc aaatataacg cccgtattct ggaaatgaac gaaacgtgtg tcgttctcga
    11581 aaagagtggt cattacgatg agacgcaagc ccttttcagg gagttgagcg aaacgatcgg
    11641 tgtcttgcag ttcatccgtt ccggtcgcat tgcgatcaca aaaagccgtg tcgagcgttt
    11701 gagcgatatg ttggccgaaa tggaacgtaa gttgcaggaa aaaaaataac gtacgggtgg
    11761 tttgcgaact gccccaacag aaaagaatca tggataaaga taaaagcaaa ataggggaat
    11821 ttcatttcgt cacggaaccg tacctgttgg attttcgtgg acgtgtaacg ataccgatga
    11881 tcggaaacta tctgatacat gtcgcatcca gccatgctgc tgaacgcgga ttcggtttca
    11941 acgatatgtc agaacggcat acggcttggg ttctttcccg tctggcgatc gaaatgatcg
    12001 aatatccagc catgtccgaa cctataactc tttatacctg ggtggatgaa gtcggccgtc
    12061 tctttaccag ccgttgtttc gagctggtgg atggcaacgg taagacattc ggttacgccc
    12121 gttctatttg ggcggctatc gatgtggaaa cacgccggcc gaccttgttg gatatcgcca
    12181 ggttgagcgc ttatgtcacg gatcgcccct gcccgataga aaagccggga aagattgcgg
    12241 ctgtggagaa tgagacggaa ggggttcctt atttcattaa gtacagcgac cttgatatca
    12301 acggccacct gaacagtatc aagtatatgg aacatcttct agacctgttt gatcttgacc
    12361 tgttcaagac aaaagatatc aaacgtttcg aaatcgccta ccagtctgaa ggcaaatatg
    12421 ggatgaaact catgttgtac aagagggagg ctgataacgg aaaatatgat atggcgatct
    12481 gtaatgaagg caaagcgatt tgccgtgctg ctgttatgtg gcattgaaca aacatggtat
    12541 gggcggatgg tttgcgaact gtcctgacaa aagaattatt ttattaacac attacattta
    12601 atagtagaaa aaatggcagt aatgaatttt ggcggtgttg acgaaaacgt agtaacccgc
    12661 gaagaatttc cgttggaaaa ggcaagagaa gtattgaaag atgaagtgat tgcagttatc
    12721 ggttacggtg ttcaaggtcc tggacagagc ttgaacttgc gtgataatgg tttcaacgtt
    12781 atcgtaggac agcgccctgg taaaacctat gacaaagctg ttgccgacgg ctgggtaccg
    12841 ggtgaaacac tgttcggtat tgaagaagct tgcgaaagag caactatcat acaggtgttg
    12901 ctttccgacg ccgctcagat cgaatgctgg ccgcgtatca aaaaatatct gactccggga
    12961 aaagcgctgt atttctctca tggttttgct atcacttaca aggaacgtac caatattatc
    13021 cctcctgctg atgttgacgt gattctagtc gcaccgaaag gttctggtac ttctttgcgt
    13081 cgtatgttcc tgcagggacg tggcttgaat tcaagctatg caattttcca ggatgcaacc
    13141 ggtagagcat gggaccgtgt gatcgctttg ggtatcggcg ttggttcagg ctatctgttc
    13201 gaaacgacat tcaagaagga agtttattcc gatctgactg gtgaacgtgg aactttgatg
    13261 ggggctatcc aaggtttatt gttggctcaa tacgaaacat tgcgtgaaaa cggccacgaa
    13321 ccttccgaag cattcaacga aacagtcgaa gagctgactc agtctttgat gccgttgttt
    13381 gctgaaaacg gaatggactg gatgtatgca aactgttcga ctactgcaca gcgtggcgct
    13441 ttagactgga tggggccgtt ccacgatgcc gttaagcctg tatttgaaaa attataccgg
    13501 gaggtcgcct gcggtaacga agcgcagcgt tctatcgata cgaacagtaa
//
