LOCUS       gnlProkkaPAONAMNP_4    16253 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|PAONAMNP_4.
ACCESSION   gnlProkkaPAONAMNP_4
VERSION     gnlProkkaPAONAMNP_4
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2025-04-28 20:13:12
            Original ID  :: gnl|Prokka|PAONAMNP_4
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16253
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16253
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[3961:6253]"
                     /cutoff="5000"
                     /detection_rule="(PF04055 and TIGR01716)"
                     /neighbourhood="10000"
                     /product="RaS-RiPP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      3962..6253
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="5000"
                     /detection_rule="(PF04055 and TIGR01716)"
                     /neighbourhood="10000"
                     /product="RaS-RiPP"
                     /protocluster_number="1"
     cand_cluster    1..16253
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(PF04055 and TIGR01716)"
                     /kind="single"
                     /product="RaS-RiPP"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..16253
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RaS-RiPP"
                     /region_number="1"
                     /rules="(PF04055 and TIGR01716)"
                     /tool="antismash"
     CDS             complement(443..1021)
                     /locus_tag="ctg4_1"
                     /transl_table=11
                     /translation="MYNEVKRFYLFRRRRWADTLFDTLYHVIFILGFYSLLRGNSDFQL
                     SYFYYYFILTHVVSLGNEELEYEIRSGQSFGTQYALQSVYRIYLQRAVVYFVWLSLIFW
                     IALLLIHQGLPTHFSLKVISFQGLFVVLIGFLIFLGYYLVMIRLTIRFQRISVLVDFLN
                     TVLLFYSGLVFPVVSFGNLKKLFDGIIRN"
     CDS             complement(1014..1754)
                     /locus_tag="ctg4_2"
                     /transl_table=11
                     /translation="MMLSAIGREFSRQLSEYKQFKVNLLFANMGIFFLVTGFLTYFDSQ
                     KDTFELFILLFTWYFSSHSITHPTYFIEDEIADRTIINVIQSRRSIFVMLFIKIIVQIL
                     LDLVKAIPLFCLVALVQQIAFPTDWVDTFVTFLLSFVVIASLYGLGFLFASFSFVFTKI
                     SSITSLLAYGILFLVGFQEQSSHLIATLTRFLPFHLLVSFIRQPSWFVLLLLLGYGLIY
                     WLLGYLCFQTCLTYAKKKGSLFHV"
     CDS             complement(1751..2644)
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 166.6; E-value:
                     1.2e-50)"
                     /gene_kind="transport"
                     /locus_tag="ctg4_3"
                     /transl_table=11
                     /translation="MTNITFSQVQKSFHKKLLLDIPDFQADSGEIFSIVGSNGAGKSTF
                     IKLLAGIFLQDKGEVRVYGVSNRSKKIHSLVKFVLESGQGLYSYLTAMENLQYFLGLNG
                     IALSHIKAEVDVLCDQLAFTPYKDTLVSELSQGNRQKLTLILALVQKPKVLCLDEPTNG
                     LDLLAKKQLMTLLQDYARYHQASIFITSHDASFIEKVSTRVVVIQEGRLYREGTFEEIF
                     GNVHQHEVYHLLLDKSSESVLRQRFSELDYKVLDGGISVETRIPDLYRLLLEETEVLQF
                     TREPASLEDLLYEVLK"
     CDS             complement(2637..2900)
                     /locus_tag="ctg4_4"
                     /transl_table=11
                     /translation="MHINNKVWFIRFEPNFQGDKKTILYNKSSGELYEVSEIYFHFLES
                     IRNKKSCQDALKQRYNTENIDIEKIIQQIKENLLNLGVILND"
     CDS             complement(2887..3972)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR04085"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SPASM"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg4_5"
                     /sec_met_domain="TIGR04085 (E-value: 7e-17, bitscore: 55.1,
                     seeds: 281, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 8.5e-10, bitscore: 32.5,
                     seeds: 166, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKSENLIETCKKIESSFDLPFYIYSKISSKSNEKVIAPLKIGLKI
                     TNECHFRCPYCFVSKNSEYLRYQDLKTVLSKLPQYPYEVYLTGGEATLHPKFDKIVDYI
                     DSLGILIKLHTTGVVPLNTEKYILNNIEKFSSIQISLDSIKNFNKLRPNLIDEDPLTQI
                     VNFCKRLQQKKFENIIVNIVISSLNVMELPEIFDFCLSNKLKYIQLSSIFTTSKRLLTN
                     DLDYLLYYEELLTTYQKQGIIFRTAPFCHPWSLAIQKGYDYRSPLYCPAQKTEFEIDMH
                     GDVYPCPFLHDEKHKMGNLLNNDFDEVWYSGVEELNHTNWSKNTKCKSCSLYKFCGGGC
                     YALASVSNKDYDMRCSLHAYK"
     CDS             complement(3962..5137)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RaS-RiPP: PF04055"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg4_6"
                     /sec_met_domain="PF04055 (E-value: 2.1e-16, bitscore: 54.2,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIFVKQNERILISCMIIGIVKILSFFIKLRNLVHFMNERTWLEVF
                     NRLYLTKDLSLNDAIKPIYVGYKIIERCNQRCVHCWAGKNDGVVPSLNDVISGLDKLKQ
                     LQPLHLTITGGEPLMHEDWFSIVQYAKNNFPIVELFTNAVLFTEESVKRLSKIFDENDY
                     VQVSLDGLEKSYMKQRGVDNFKHVVANIQLLVTYGINVRVNMTITHLNVNDMLGVYELL
                     RDIGIASFSISPVYPLRRGKNLIPLVDYDEYLVNSEKIKKLYSKTKETMHLEIIYPIEI
                     QSREARKLENSKDISRFNLDLLHWTIDAKGDIFHFMDHFPIKELKIGNIYSNTTDELLS
                     KDYKIQTSIMYHSSVGTKCSQCTLNDYCTGFGYLNSYPEIASDFRRCSFEI"
     CDS             complement(5159..5284)
                     /locus_tag="ctg4_7"
                     /transl_table=11
                     /translation="MSSLEKRELMETKLTAIDLSVEKIDCGKIKLYKSWSKSHGH"
     CDS             complement(5381..6253)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RaS-RiPP: TIGR01716"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg4_8"
                     /sec_met_domain="TIGR01716 (E-value: 4.9e-44, bitscore:
                     144.0, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLTKFGEIYKLFRESRKITLRDIEHRGISRSQLSRFEKGETDLTT
                     TKFFLALEQINVPIEEFMYAVKDFKRDCFYQLIDEVKQCFLNRNVPKLHKMLIKRMEND
                     DTSIFSTIEIIFLKIKLQELSGEEYFNDTDINRITDYLFGVNYWGMFEILLFGNIMYIF
                     NYETFLLLSKELLHRTEFYHDIPSYRRVIASIALNAFIICIERDYLVDAKYFEKQISRF
                     YFDESEIYERLIYTYARSFYEFKKKQTTQSILKMRKVIGFMRVVECEKLAERYEEHLNK
                     ILSSFSDDN"
     CDS             6623..7318
                     /locus_tag="ctg4_9"
                     /transl_table=11
                     /translation="MKEKILAYVKDNRLFVSVIAVLMVIFCFFLWMTCGAGSSMEAETS
                     YTDVTALSTSSSKQSSQSLSEASSQSKTEGSEKVKSKVTVDVKGAVVNPGVYTLKAGAR
                     VTDVIQEAGGMTEDADAKSVNLAASLSDEEVIYVANKDENVSVLDQTGTGQVSDKGGQA
                     VSKDGKINLNTATSEQLQTISGIGAKRTEDIIAYRESHGGFQSVDDLKNVSGIGDKTLD
                     KIRESLYVA"
     CDS             7308..9548
                     /locus_tag="ctg4_10"
                     /transl_table=11
                     /translation="MWLKKAPINLFSLALLIVALYFTIFVSNFYAIGTFVFLMICFLRH
                     HWKNRAALKLVGLIGGFFLVYFLFLYHIAIMQDKQTPAEIHQVTLVADTLSVNGERLSA
                     IGKSNGQTYQVFYRLKSDREQHFFKTTSQTLVLKGKIKLSSATGQRNFQGFDYQSYLAS
                     QGIYRIAQIERLEHVVTPKSISPIAFFHQLRRKTLVHIQTHFPNPMRHYMTGLLFGYLD
                     KEFDEQSQLYTSLGIIHLFALSGMQVGFFLGWFRYGLLRLGLPKNYILAILLPFSIFYG
                     LMTGWTASVLRSLIQSLLAECGIKKLNNMGITLLLFFLVLPHFLLTVGGVLSCSYAFLL
                     CLFNFEEMSSFKKSIYMSLVLSLGTLPFLTYYYGTFQPLSLILTAIFSLVFDSFLLPVL
                     TVLFTLSGMVIFSQFNTLFEWMEFFLTWVQSWGVQTLILGKPSLFQFVSMIFVLVLLFD
                     FWKKPQFRISLLMIFSLLMVWVKHPLINEVTVVDVGQGDSIFLRSMKGETVLIDVGGKV
                     TFGSKEKWQEGSQTSNAEKTLIPYLQARGVSQIDYLVLTHTDTDHIGDLEVVAKRFKIK
                     KICVSEGALTKPSFAKRIRFLKCPVRTLKAGDKLPMMGSNLQVLYPNKIGDGGNNDSLV
                     LYGKLLGTSFLFTGDLEKEGEEELMASYPNLKVRVLKAGHHGSKGSSSEAFLDQLKPSL
                     ALVSAGENNRYKHPNDETLERFKERHIKVLRTDQDGAIRFKGWFQLSSETVR"
     CDS             9634..10896
                     /locus_tag="ctg4_11"
                     /transl_table=11
                     /translation="MRKIIINGGKKLQGEVTVSGAKNSVVALIPAIILSDGVVTLDGVP
                     AISDVDNLIEIIEVMGGSVKRDGETLEIDPRGVKDMPMPFSKINSLRASYYFYGSLLGR
                     YGQAIVGLPGGCDLGPRPIDLHLKAFEAMGASIFYEDEAMRIATDAGQRIKGAHIYMDT
                     VSVGATINTMLAAAKADGRTVIENAAREPEIIDVATLLNNMGARVRGAGTEVITIEGVE
                     SLHGTRHQVIPDRIEAGSYIAMAAAIGKGIKIKNVLYEHLESFICKLEAMGVRMTVEED
                     AIFVEEQGDLKPVDIKTSPYPGFATDLQQPMTPLLLKASGRGKIIDTIYEKRINHVPEL
                     ARMGADIQVLGGQIVYNGPTQLSGAPVKASDLRAGAALVTAGLMADGQTEITNIEFILR
                     GYSNIIEKLSDLGADIRLIED"
     CDS             10962..11507
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1111:GCN5-related N-acetyltransferase (Score: 100.9;
                     E-value: 1.3e-30)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg4_12"
                     /transl_table=11
                     /translation="MDIWTSLGAFAFFESERLSFRPLVFLDRFDLHEIVSNPENLQFFF
                     PATQTQYETDCLLVHYFMKEPLGVWAIVDRESNKLIGIVRFEKIDVQKRTAELGYFLNA
                     LYWGRGIMTETVTCLSDLALTAMGMERIILIAHLENKASIRVAEKSGFKLVSRFKGADR
                     YTRTMRDYLRFEKEKNCE"
     CDS             11500..12780
                     /locus_tag="ctg4_13"
                     /transl_table=11
                     /translation="MSKHQEIMDYLEALPIGKRVSVRSISNHLQVSDGTAYRAIKEAEN
                     RGLVETRPRSGTVRIEKKVQVRLDKLTFAEIAEITESEVISGHEGLERVFSKFYIGAMT
                     IENITRYLTKGDLLIVGDREDIQLLALEYNNAILVTGGFRVSDRVKELSRLKQFPVMVT
                     TYDTFTVATMINQALSNVRIKTEIKTVAQVYTRREEYNYMTPEMTVKDFQNLVKRTNLV
                     RFPIVSEDDRVIGIVTMRDVANQLPTTMAKAIMTKPTVTRLEASLASVAQKMIFEDYDM
                     IPVVDDEKHYLGTITRRQVLEELQDNNRGDLHTFSDQMIANLNREKNAFSFEVEPTMID
                     NSGNLTQGVLVEMVKEVVYRTMEKQEQNSLVFEEMMFYFLQAAQIDDKVKITPSIIAET
                     RRRAHLDLMVTHGNHAVCKSVVVVKKT"
     CDS             12824..13684
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1172:methionine aminopeptidase (Score: 266.7; E-value:
                     5.3e-81)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg4_14"
                     /transl_table=11
                     /translation="MITLKSAREIEAMDRAGDFLASIHIGLRDLLKPGVDMWEVEEYVR
                     RRCKEENVLPLQIGVEGSIMDYPYATCCSLNDEVAHAFPRHYILKDGDLLKVDMVLSEP
                     IDKSVLDVSKLDFDNVAQVKKYTESYAGGLADSCWAYAIGTPSDEVKNLMEVTREAMYL
                     GIEQALVGNRIGDIGAAIQEYAESRGYGVVRDLVGHGVGPTMHEEPMVPNYGVAGRGLR
                     LKEGMVLTIEPMINTGTWEIDTDLETGWAHKTLDGGLSCQYEHQFVITKDGPVILTSQG
                     EERTY"
     CDS             13704..14651
                     /locus_tag="ctg4_15"
                     /transl_table=11
                     /translation="MARLLDKLQWRPFQVYLSHYRSAEIDISSIAVAYYLILTVFPLIV
                     IAANVFPYLNIDTTDLLKFMNEHLPKHFYAPAANVVQDIFSTPSGRLLGVASLTGFWTM
                     IKSLSSLQKAIDKVYGASEHRDVFISHIIGGLLSLVILFLLTFALMLSTIIQSVLRVIN
                     QTYPIGSNLTQLILNSIQPLSVAVVFLGMMVLYFILPNVKIRKIRYIMPGTIFTTLVIG
                     YLSNLFGTYVIHTLSRLIDIKLFGSIMIFIFIFMLWFIFLARILIFGAVFNATYQELKQ
                     GELHSRRGDVLTIIQSFSGDGSNSKKTKNDRDKS"
     CDS             14742..15251
                     /locus_tag="ctg4_16"
                     /transl_table=11
                     /translation="MKNKTVRDLTHIAIVAALYVVLTIVPPFNLISYGPYQFRIAEMFN
                     LLGFYNRKYIIAVTLGCVIANFFSFNMIDVVVGSLSTLVFVGSGVYFFDRFKNQDILGG
                     LFDKAHVYFAFYFSFFMVTIAAELSLVAQAPFWATWFTVALGELASLLVGAVLIKKLAK
                     VIDFVS"
ORIGIN
        1 aaatttctct ggagaagaaa aacaatgact atttttagtt taatagcgag gggagaaacc
       61 tcataacact aaaaacagaa aggatagtta tgcttttagg aaggtccctg attcataact
      121 aatagaactt aatagaactt aatagaactt aatagattat gttagatgcg agaggagaaa
      181 tctcgtctaa ccttacaaca acaatggtta ggtcaaggcg aggggagaaa cctcgttcct
      241 taaccttgat ataagtatat cataatagat cttgtattcg aagctcagag gacactttat
      301 ttcacttttt ttatattttt tttaaccaaa tttcgtaaat gctatcaact ataaggggag
      361 tatgtcacct tcaccgtctc agaggttagg aattgaaaga agatttcaat ataaaaaagg
      421 actctgcatt gaaaaagaat ccttaatttc ttataatccc atcaaataat ttcttcaagt
      481 tcccaaaact caccactgga aagacgagtc ctgagtagaa taagagtacg gtgtttagaa
      541 aatctaccaa gactgaaatt cgttggaagc ggatagtcag tcgaatcatg acaagataat
      601 agccgaggaa aatcaggaaa ccaatcagta ccacgaacag tccttggaaa ctgatgacct
      661 tcaaagaaaa gtgagttggt aaaccctgat gaatcaaaag cagagcaatc cagaagatca
      721 aagacaacca aacaaagtaa accactgctc gttgcaggta aattctatac actgattgca
      781 aagcatactg ggtaccaaaa gattgcccag accgaatctc gtactccaac tcttcatttc
      841 ccaaggaaac cacatgagtc aagatgaaat aataatagaa ataggacaac tgaaagtcag
      901 aatttcctct caaaaggcta taaaaaccaa gaatgaaaat gacgtggtag agggtgtcaa
      961 acagggtatc cgcccagcgt ctcctgcgaa agagataaaa tcgcttcact tcattataca
     1021 tggaacaaac ttcccttctt tttggcatag gtcaaacaag tttgaaagca caagtaaccc
     1081 aagagccagt aaatcaaacc gtatcccagt aataataaaa gaacgaacca acttggctga
     1141 cggataaaac tcaccaagag atggaaaggc aagaaacgag ttaaagtagc aatcaaatga
     1201 ctcgattgtt cctgaaaacc aaccaaaaag agaatcccgt aagcaaggag gctagtaata
     1261 ctggaaattt ttgtaaagac aaaggaaaaa ctggcaaaga gaaagcctag accataaagg
     1321 gacgcaataa ccacaaagga cagaagaaag gtaacaaatg tatcgaccca gtcagtagga
     1381 aaggcaatct gctgaaccaa ggcaaccaag caaaacaaag gaatggcctt gaccaagtcc
     1441 aacaaaatct gtacgataat tttgataaaa agcatgacaa agatgctcct ccgactctga
     1501 atcacgttga taatggtgcg gtctgcaatc tcatcctcga taaaataggt cggatgagtg
     1561 atactgtggc tagaaaaata ccaagtaaaa agcaagataa acagctcaaa agtatctttc
     1621 tgactgtcaa aataggtcag aaaacccgta actagaaaga aaattcccat gttagcaaag
     1681 agaagattga ctttgaactg tttgtattcg ctgagttgac gactaaactc tctcccaatc
     1741 gctgatagca tcatttgagc acctcataca gcaaatcttc caaagaggca ggttctcggg
     1801 taaactgtaa gacttccgtt tcttccagca atagccgata aaggtctgga attctggtct
     1861 ctaccgaaat cccaccatca agcaccttgt agtccagctc agagaatctt tgtctcagta
     1921 cactttctga actcttatct aacagcaagt gatagacttc atgctggtgg acattaccaa
     1981 aaatctcctc aaaggttcct tctcgataaa gccgtccctc ctgaattacc accacccgag
     2041 tgctgacctt ctcgataaaa ctagcgtcat gactggtgat aaaaatactg gcttgatggt
     2101 aacgagcata atcctgcaaa agagtcatca gctgtttttt tgccagcaaa tctagcccat
     2161 tggtcggctc atccaaacag agtactttcg gtttttgcac caaggctaag attaaggtca
     2221 atttttgacg gttgccctgg gacagttctg aaaccagcgt gtccttataa ggggtaaaag
     2281 ccagctggtc acacaagaca tccacctctg ccttgatatg agacaaggca atcccattca
     2341 agcctagaaa atattggaga ttctccatag ctgtcaaata actgtacaac ccctgcccgc
     2401 tctccaagac aaacttgacc agcgagtgga ttttcttgga gcgattagaa acgccataga
     2461 cacgaacctc gcccttatcc tgcaaaaaaa tccctgccaa gagcttgata aaagtcgatt
     2521 tcccggcacc attgctacca acgatggaga agatttcacc tgaatccgct tgaaaatcag
     2581 gaatgtctaa caacaacttc ttgtgaaaac tcttttgaac ttgtgaaaat gttatgttag
     2641 tcatttaaga taacccctag atttagaaga ttctctttaa tttgttgaat tattttttca
     2701 atatctatat tttcagtatt atatcgttgc tttagagcat cttgacaact tttcttattt
     2761 cttatacttt ctaaaaaatg aaaatatatt tcagatactt catatagttc gccactagac
     2821 ttattatata atattgtctt tttatctcct tgaaaattag gctcaaaacg aataaaccac
     2881 actttattat ttatatgcat gtaaactaca cctcatatca taatccttat tagacacact
     2941 cgccagagca taacaacctc caccacaaaa tttatatagt gaacaggact tacatttagt
     3001 atttttgctc caatttgtat ggtttagttc ttctactcca gaataccata cttcatcaaa
     3061 gtcattattc agtaaattcc ccattttatg tttttcatcg tgcaaaaacg ggcaaggata
     3121 aacatcgcca tgcatatcta tctcaaactc tgttttttgt gctggacaat ataaagggga
     3181 tcggtaatcg taaccttttt gaatagccaa agaccatgga tgacaaaaag gagctgttct
     3241 aaaaattatt ccttgttttt gataagtagt taataattcc tcataataaa gcaagtaatc
     3301 aagatcatta gttaacaatc gtttactcgt agtaaatatt gatgataact gaatatattt
     3361 caacttatta gataaacaaa aatcaaaaat ttctggaagc tccattacat ttaaagagct
     3421 tattacaata ttaactatga tattttcaaa tttcttttgt tgtaatcttt tacaaaaatt
     3481 aacaatttga gtcaaaggat cttcatcaat tagatttggt ctcaatttat taaaattctt
     3541 tattgagtct aaactaattt gaatcgatga aaatttttca atattattta atatatattt
     3601 ttctgtatta aggggaacta cacccgtcgt atgtaattta atcaaaatac ctagactatc
     3661 tatataatca acaattttat caaatttcgg atgaagagtt gcttctcccc cagtcaaata
     3721 aacttcgtat ggatattgag gtaatttgga caaaacagtt ttcaaatcct gatatctcaa
     3781 atattccgaa ttcttactta caaaacaata aggacatcta aaatgacatt cattagttat
     3841 tttcagacca atcttcaaag gcgcaattac tttttcattg cttttagaac ttatctttga
     3901 atagatataa aatggcaagt caaaacttga ctctattttt ttacatgttt cgatcaaatt
     3961 ttcagatttc aaagctacac ctcctaaaat ctgaagcaat ctcagggtag gaattaagat
     4021 atccaaaccc cgtacaataa tcattcaagg tacactgtga acattttgtt cccaccgaac
     4081 tatgatacat aatagaggtt tgaatcttat aatcctttga tagtaactcg tcagtagtgt
     4141 tagaatatat attccctatc ttgagttctt ttataggaaa atgatccata aaatgaaata
     4201 tatctccctt tgcgtctatt gtccaatgta ataaatctaa attgaaacga gaaatatctt
     4261 tcgaattctc caattttcta gcttctctag attgaatttc tattggataa attatttcaa
     4321 gatgcattgt ttctttagtt ttagaataca atttttttat cttttcagaa tttacaaggt
     4381 attcatcgta atcaactaac ggaattaagt tctttcctct tcttaacgga taaactggag
     4441 agatagaaaa cgaagctatt ccaatatctc tcaacaactc atatactcct aacatatcat
     4501 taacatttag atgagtaata gtcatattga ctcgaacatt aatgccataa gtcacaagta
     4561 attgaatatt tgccaccaca tgcttgaaat tatctacacc tctctgtttc atgtaactct
     4621 tttctaaacc gtccaaactc acttgaacat agtcattttc atcaaaaatt tttgataatc
     4681 tcttcacaga ttcttctgta aataaaacag cattagtgaa taactcaaca attggaaaat
     4741 tgttttttgc atattgaact attgaaaacc aatcttcatg cattaaaggt tctccacctg
     4801 ttatggttaa atgaagaggt tgaagttgtt taagtttatc aagtcctgat ataacgtcat
     4861 ttaatgacgg taccacccca tcattttttc cagcccagca gtgaacacaa cgttgattac
     4921 atctctcaat aattttataa cctacataga taggttttat tgcatcattt aacgataaat
     4981 cttttgttaa atacaaacga ttaaaaactt ccaaccaagt tctttcattc ataaaatgca
     5041 ccaagtttct taatttgata aaaaatgaga gaattttaac aataccaata atcatacagg
     5101 aaattaaaat tctctcattt tgcttcacaa atatcatcgc taatcaatat aaagctcatt
     5161 aatgaccatg tgatttagac catgatttgt ataacttaat ctttccgcaa tcaatttttt
     5221 ctaccgacaa atcgattgct gttagtttag tttccattag ttcacgtttc tctaaactag
     5281 acatgactat ccctccctta cttcaaattg tatttgtaag cttacgagta tagtatatca
     5341 ctttataaat ctaattctat tttgtcccga atctgctctt ttaattatca tctgagaaag
     5401 aagacaatat tttatttaaa tgttcttcat atctttctgc aagtttctca cattcgacta
     5461 cacgcataaa tccaattact tttctcattt ttaggattga ttgtgttgtc tgcttttttt
     5521 taaattcata aaaagatcgt gcgtatgtat aaattaaacg ctcataaatc tcagattcat
     5581 caaaataaaa acgagaaatt tgtttttcaa agtattttgc atccactagg taatcccttt
     5641 caatacagat aataaaagca tttagagcta tactagcaat cactctccta taactaggta
     5701 tatcatgata aaattctgtt ctatgtaaca gttctttaga taacaatagg aacgtttcgt
     5761 aattaaaaat gtacatgata tttccaaata ataaaatttc aaacattccc caataattaa
     5821 caccaaataa gtaatcagtt attctattta tatccgtatc attaaaatat tcttcgccag
     5881 aaagttcttg taattttatt tttaaaaaaa taatttctat tgtggaaaag atagaagtat
     5941 catcattttc catgcgttta atcaacattt tatgtaattt aggcacattt ctattaagaa
     6001 aacactgctt gacttcatct attagttgat aaaaacaatc tcttttaaaa tccttaacag
     6061 catacataaa ttcctcgatg ggtacattta tctgttcaag agctaaaaaa aattttgttg
     6121 ttgttaaatc tgtttctcct ttttcaaacc tagacagctg tgaacgtgat atccctctgt
     6181 gctcaatgtc tctaagagta atttttcttg attctctaaa taatttatat atttccccaa
     6241 attttgttaa cattctatac ctccatgagc aaatatggga cagttctaaa ataaagcctc
     6301 ttcatgtgat aaaatataca tagattatat catataatta aagtttttat taatttattc
     6361 aaggaggttt cacatgaata tttctataaa aagattccta atgattttac ttgaaattat
     6421 cattatcatc gccttataat tatcattcag taatttaggt cctatattta aaaagagttc
     6481 ttatgagact ttttgtgtac actcaaaaag ctctataatt tctactatta ggagtcatta
     6541 gcgatggagt ttttttcttt ttgatatatt tttcaagttt tttacgaata agaaagaaaa
     6601 tatatcaatt aaggagaata gcgtgaagga aaagattcta gcctatgtca aagataatcg
     6661 tctgtttgtg agtgtcatcg ctgtactgat ggtgattttt tgcttctttt tatggatgac
     6721 ttgtggtgcc ggcagcagca tggaggcgga gacgtcttat acagatgtga cagctttgtc
     6781 aacgtcttca tccaaacaaa gttcacagtc tctttctgag gcgtcttccc agtcaaagac
     6841 cgaaggaagt gaaaaagtta agtcaaaagt aacggtagat gttaaggggg ctgtggtcaa
     6901 tccaggtgtc tatacgctaa aggcaggcgc tagggtgaca gatgtcattc aagaagctgg
     6961 aggaatgaca gaagatgcag acgctaagag tgttaactta gccgcaagct tgtcagatga
     7021 agaggttatt tatgtagcca ataaagatga aaatgtttct gtccttgatc aaacaggtac
     7081 tggtcaggtc tctgataaag gagggcaggc tgtatctaag gatggcaaaa ttaacttaaa
     7141 tacagcaacc tcagagcagt tgcaaaccat ttctggaatt ggagctaagc ggacagagga
     7201 tatcattgcc tatcgtgaaa gtcatggcgg ctttcagtcc gtagatgact tgaaaaatgt
     7261 ctcaggaatt ggtgataaaa cattagataa aatcagagag tccctctatg tggcttaaaa
     7321 aagctccaat caatcttttt tccctagcgc ttttaatagt tgctctttat tttactattt
     7381 ttgtatctaa tttctatgct attgggactt ttgtctttct gatgatatgt tttttgaggc
     7441 atcattggaa gaatagagca gctctaaagt tggtgggact tataggtggt ttctttttgg
     7501 tctacttttt atttttatac catatagcta tcatgcaaga taaacaaact cctgctgaaa
     7561 ttcatcaggt gacactggtt gcagatacgc tctcagttaa tggtgagcga ttatcagcaa
     7621 tcgggaagtc aaatggacaa acctatcagg tcttttaccg gctaaaatct gatagggagc
     7681 agcatttttt taagactact agtcaaacgc ttgttttaaa agggaaaata aagttgtcct
     7741 cggcaactgg tcaacgtaat tttcaaggat ttgattatca gtcttatcta gctagtcagg
     7801 gcatttatag gattgctcag attgagcgcc tggaacatgt cgtaacccca aaatcgatat
     7861 ctccaatagc tttttttcat caattgagga ggaagactct agttcatatt cagacgcatt
     7921 ttcctaatcc gatgagacac tacatgacag gactgctctt tgggtatttg gacaaggagt
     7981 ttgatgagca gagtcaactc tacactagct tggggattat tcatcttttt gcgctatcgg
     8041 gtatgcaggt tggatttttt cttggctggt ttcgctatgg acttctccgt ttggggcttc
     8101 ccaaaaatta tatccttgct atcttattac ctttttcgat tttctatggc ttaatgactg
     8161 gttggacggc ttcggtctta cgttctttga ttcaaagcct cttggctgag tgtggtatta
     8221 aaaaactgaa caatatgggc ataacgctac ttctattttt tctagtcttg cctcattttc
     8281 ttttaacggt aggaggtgtt ttaagttgtt cttatgcctt cttgttgtgt ttatttaatt
     8341 ttgaggagat gtcgtccttt aaaaagtcaa tttatatgag tttagtattg agtcttggga
     8401 ctttgccttt tttgacctac tattatggaa cttttcaacc attgagtttg attctgacgg
     8461 caatcttctc tctagttttt gatagctttc tcttacctgt cttaacagta ctttttacac
     8521 tttcaggaat ggtaattttt tctcaattta acacactttt tgaatggatg gagttctttt
     8581 tgacttgggt acaatcttgg ggagtccaga cattgatttt aggaaaacct agcttgtttc
     8641 agtttgtctc aatgatattt gtattggttt tgctctttga tttttggaaa aagcctcagt
     8701 ttagaatatc cctcttgatg atttttagtc ttttgatggt ctgggtcaaa catcctttaa
     8761 taaatgaagt aacggtggtc gacgttggtc aaggagatag tattttttta aggagtatga
     8821 aaggtgaaac ggtcctaata gatgtaggtg gcaaggtgac tttcggctct aaggaaaaat
     8881 ggcaagaggg gagccagacg agtaatgcgg agaaaacctt aattccctat ctacaggcaa
     8941 ggggagtgtc tcaaattgac tatctggttc tgactcatac ggatacagac catattggtg
     9001 atttggaggt agtggctaaa cggtttaaga ttaagaaaat ttgtgtcagt gagggggctt
     9061 tgactaagcc tagttttgcc aaacgtattc gatttcttaa atgtcccgtt cgcactttaa
     9121 aggctggtga taagctgcct atgatgggaa gtaacctaca ggttctttat cccaataaaa
     9181 ttggtgatgg tggtaacaat gattcacttg ttctctatgg aaagttattg ggaaccagtt
     9241 ttctatttac tggtgatttg gaaaaagaag gagaagagga attgatggct agctatccaa
     9301 atttaaaagt aagggtcctc aaagcaggac atcacggttc taaaggctct tcatcagaag
     9361 cttttttgga tcagctaaag ccatcacttg ctcttgtctc agcaggtgaa aataatcgtt
     9421 ataagcatcc aaatgatgaa acattagagc gtttcaaaga acgtcacatt aaggttttac
     9481 gcacagacca ggatggtgcc attcggttta agggatggtt ccaactatca agtgaaactg
     9541 tccgataatt gtttggattc ttaatttgtc atgcacctca atctatggta gaatgtaaag
     9601 gttaatattc aagtataaga aagattgagc agtatgcgta aaattatcat caatggtggt
     9661 aagaaacttc aaggagaagt tacagtatca ggagctaaaa attcagttgt tgcattgatt
     9721 ccagccatca ttttatctga tggagtggtt actcttgacg gggtaccagc aatcagcgac
     9781 gtcgataatc taattgagat tattgaagta atgggtggtt ctgttaagcg tgatggcgaa
     9841 acacttgaaa tcgaccctcg aggcgttaaa gatatgccaa tgccatttag taagattaac
     9901 agccttcgtg cttcatatta tttctatggt agtttgcttg ggcgttatgg tcaagctata
     9961 gtaggtttgc ctggtggatg tgatttagga ccgcgtccta ttgaccttca ccttaaggcc
    10021 tttgaagcta tgggtgctag cattttctat gaagatgaag ctatgcgtat tgctacggat
    10081 gccggccaac gtatcaaggg tgctcacatc tatatggata cggttagtgt gggggcgact
    10141 atcaatacca tgttggcagc ggctaaggct gacggtcgta ctgttattga aaatgcggct
    10201 cgtgaacctg agattattga tgtggcaacg cttctcaaca atatgggtgc gcgtgtacgt
    10261 ggcgctggta cagaagtcat cacgattgag ggtgtagaga gcctacatgg tactcgccat
    10321 caagttattc cagaccgtat tgaagcaggc tcatacattg ccatggcggc agctatcggt
    10381 aagggaatta aaattaaaaa tgttctctat gaacaccttg aaagttttat ttgtaagctt
    10441 gaagcaatgg gtgttcgcat gaccgttgaa gaggatgcaa tctttgtgga agaacagggt
    10501 gatttaaaac ctgttgacat taagacatca ccttatccag gttttgcgac ggatttacaa
    10561 caaccaatga caccattgtt gttgaaagca agtggccgag gaaaaatcat tgatacgatc
    10621 tatgagaagc gtataaatca cgttcctgaa ctggctcgta tgggtgctga tattcaagta
    10681 cttggtggtc agattgttta taatggtcca acgcaacttt ctggtgcacc tgtgaaagct
    10741 agtgatttgc gtgcgggtgc tgcactcgtt actgcaggac ttatggcaga tggtcagact
    10801 gaaataacaa acattgaatt tatccttcgg gggtattcaa atatcattga gaaactttct
    10861 gatcttggtg cggatattcg tttgattgaa gattaagtct aaggtttaac cgctagtggt
    10921 tgagcctttt tccatttcta aaactgtgtt ataatactat catggatatt tggactagtc
    10981 tgggtgcttt tgccttcttt gagtcggagc gcctttcttt tagaccactc gtctttttag
    11041 atcgttttga cttacatgag attgtgtcaa atccagagaa tttacaattt ttctttcctg
    11101 ctacgcaaac tcagtatgaa acagattgcc tcttggtaca ttatttcatg aaggagcctt
    11161 tgggtgtttg ggcaattgta gatcgagagt ctaataagtt gattgggatt gttcgctttg
    11221 aaaagataga tgtccagaaa aggactgcag agctcggtta ttttttgaat gctttatact
    11281 ggggtagagg tataatgact gagacagtta cttgtttgtc agatttggca ttgacagcta
    11341 tgggaatgga acgcattatc cttattgctc atttggaaaa taaggcatcg attcgtgtgg
    11401 cagaaaagtc tggctttaaa ctggtgtctc gtttcaaagg agcagaccga tacacccgta
    11461 ccatgcgaga ttatctccgc tttgagaagg agaagaactg tgagtaaaca tcaagaaatt
    11521 atggattatc tagaggcttt gcccatcggt aaacgagtta gtgtgcgtag tatttctaac
    11581 cacttgcagg tttctgatgg aactgcttat cgagccatta aagaagctga aaatcgaggg
    11641 ctagttgaaa cgcgtcctcg aagtggaaca gttcgaattg aaaagaaagt tcaagtacgg
    11701 cttgacaaac tgacctttgc ggagattgca gagattacag agtctgaggt gatttcgggt
    11761 catgaaggtt tagaacgtgt cttcagtaag ttctacattg gggccatgac tattgagaat
    11821 atcacccgtt atctaacaaa aggcgacctt ctcattgttg gagacaggga agatatccag
    11881 ttattagcct tagaatacaa taatgctatt ctggtaactg gaggctttcg ggtttctgat
    11941 agggttaaag agctttctcg tttgaagcag tttccagtca tggtcactac ttacgacaca
    12001 tttactgtgg cgactatgat taatcaggca ctttcgaatg ttcgtattaa aacagaaatt
    12061 aaaacagttg ctcaagtcta tactagacga gaagaataca actatatgac tccagaaatg
    12121 acagtcaaag attttcaaaa tttggttaaa cggactaacc ttgttcgttt tcctattgtg
    12181 tctgaggatg atagggttat tgggattgtg accatgcgtg atgtggctaa tcagcttcct
    12241 accactatgg ctaaggctat tatgacaaaa ccgacagtaa ctcgtttgga ggctagcctt
    12301 gcgtctgtgg cacaaaagat gatttttgaa gactatgaca tgattcctgt tgtggatgac
    12361 gaaaaacatt atttagggac tatcactcgt cgtcaggttt tagaggaact tcaagataat
    12421 aaccgtggtg atctccatac atttagcgat caaatgatag ctaaccttaa tcgtgaaaag
    12481 aatgccttta gttttgaggt agaaccgacc atgattgata attctgggaa ccttacacag
    12541 ggtgttcttg tagaaatggt taaagaggtt gtttaccgaa cgatggagaa acaagaacaa
    12601 aatagtctgg tgtttgaaga gatgatgttt tactttctgc aggcggctca aattgatgat
    12661 aaggtgaaga ttacacccag tatcattgcg gaaaccagac gcagagctca tttagacctt
    12721 atggttactc atggcaatca tgcggtttgt aagtcagtag tagtggtcaa gaaaacttaa
    12781 taagccattt aaaattaaag aaataaagaa aacggagaaa ataatgatta cactgaaatc
    12841 agcacgtgaa attgaagcga tggatagagc gggagatttt cttgcaagta tccacattgg
    12901 cctacgtgat ctcttgaaac caggagtgga tatgtgggaa gtagaagagt atgttcgtcg
    12961 tcgttgtaaa gaagaaaatg ttctgccact tcagattggg gttgaaggaa gcatcatgga
    13021 ctatccttat gcgacatgtt gtagtcttaa tgatgaagta gcacacgctt ttccacgtca
    13081 ttatattttg aaagatggag acctcttgaa agttgatatg gtcttgtcag aacctattga
    13141 taagtcagtg cttgatgtat caaaattgga ctttgataat gttgcccagg taaaaaaata
    13201 tacagaatca tatgctggtg gtttggctga ctcatgttgg gcatatgcga ttggaacgcc
    13261 ttctgatgag gttaaaaacc ttatggaagt aacccgtgaa gccatgtatc ttggtattga
    13321 acaagcgtta gttggtaatc gtatcggtga tatcggtgca gctatccaag aatacgctga
    13381 aagtcgaggc tatggtgtcg tacgtgattt ggtcggacac ggagttggac caacaatgca
    13441 tgaagaacca atggttccta actatggcgt ggctggacgt ggtcttcgcc ttaaagaagg
    13501 aatggtcttg accatcgagc caatgattaa cacaggaact tgggaaatcg atacagacct
    13561 tgaaactggt tgggctcata agacacttga cggtggcctt tcatgccaat atgagcacca
    13621 atttgtaatt actaaagatg gtccagtaat tttgacttct caaggggaag aaagaactta
    13681 ttaatatgaa acgacaaggc ataatggccc gtctcctaga taagcttcaa tggcgccctt
    13741 ttcaggttta tcttagccat tatcgtagtg ctgagataga tatttctagc attgctgtgg
    13801 cttattattt gattttgacg gtctttccgc tcattgtcat tgctgccaat gtctttccct
    13861 atctgaatat tgatacgact gatctcttga agtttatgaa tgagcatctt cctaagcatt
    13921 tttatgcacc tgcagctaat gttgttcagg atatcttctc cacaccttct ggacggttgt
    13981 tgggagtggc ctctttgacg ggattttgga ccatgattaa gtccttatct tcgcttcaaa
    14041 aagcgattga caaggtatat ggtgcttcag aacaccgtga tgtctttatc agtcatatca
    14101 ttggtggact cttgagtttg gttatcttgt ttttgttaac ctttgcgctc atgttatcta
    14161 caattattca gtcggtcctt cgggtaatca atcagaccta tcctattggg tctaacctaa
    14221 ctcaactgat tttgaatagt attcagccct tgagtgttgc agttgtcttc ctgggaatga
    14281 tggtacttta tttcattctt ccgaatgtaa agattcgaaa aatccgctac atcatgccag
    14341 ggactatctt tacgactttg gtgattgggt atctgagcaa tttgtttgga acttacgtga
    14401 ttcatacctt gagtagattg attgatatca agctgttcgg atcgattatg attttcatct
    14461 tcatcttcat gctttggttc atcttcctag ctagaatatt gatttttggt gccgtcttta
    14521 atgcgaccta tcaggaactt aaacaaggtg aactacacag taggaggggt gacgtactta
    14581 ccataattca gagtttttct ggagacggta gtaacagcaa aaaaacaaaa aatgataggg
    14641 ataagtcata gagcataaag agagcttggc taagcccagg ctcttttgat ggattagttg
    14701 gtccttgtta gtagaaaaac atctcattta tggaggaaaa gatgaaaaac aaaactgttc
    14761 gtgatttaac acatattgcg attgtggcgg cactttacgt ggtcttgacc attgtgccac
    14821 ctttcaactt gatttcgtat ggtccttacc agttccgtat tgcggaaatg ttcaatcttt
    14881 taggatttta taatcgcaag tatatcattg ctgttacttt gggatgtgtg attgctaatt
    14941 tctttagttt taacatgatt gatgtggttg ttggcagtct ctcaacgcta gtttttgttg
    15001 gttcaggtgt ttatttcttt gaccgcttta agaatcaaga tattttgggt ggtctctttg
    15061 ataaggctca tgtttatttt gccttttatt tctcattctt catggtgacc atcgctgcag
    15121 agttgtcctt agttgctcaa gcgccatttt gggctacttg gttcactgtc gctttaggag
    15181 aactggcatc acttttagtt ggtgcggtcc ttatcaagaa attagccaaa gtaatcgatt
    15241 ttgtttctta aattaacgtc tgtaaaggcg tttttttctg cttttatgtt aaaatgttcc
    15301 tatggaaaaa cgaatgaaag agctggttga caaacttaac cagtatgcaa aagagtatta
    15361 taccgaggat aatccatcgg tgtcagatgc cgagtatgat aagctctatc gtgagttagt
    15421 aactttagag gctgaacacc cagaacttgt tcaggcggat agccctacgc accgtgtggg
    15481 tggcctggtt cttgatggtt ttgagaaata ccaacatgag tatccgcttt atagtttgca
    15541 ggatgctttt tcacgagaag agctagatgc cttcgataag aggatcaagt ccgaatttcc
    15601 taacgctgac tatatggccg agctcaaaat tgatggcctt tcaatttctc taacctatgt
    15661 ggatggtatt cttcaagtag gtgcaacgcg aggtgatggt tctgttggtg aaaatatcac
    15721 tgaaaatgtt aagcgaatct cggatattcc tctgaagttg gatcaaccgc ttaatatcac
    15781 cgttcggggt gagtgttatt tgccacgagc tgagtttgaa cgcatcaaca cccagcgcca
    15841 ggagaatggt gaggccgaat ttgccaatcc acgtaatgct gcagcaggaa ctcttcgtca
    15901 attagatacg aaagtagttg ctgagcgtcg tttggccacc ttcttttatc aagaagctgg
    15961 tcccactgag cgcctgacac aaaatgatgt cttgaatgaa gtggcagaac ttggcttctc
    16021 cgttaatcca cgccgtattg tgacatcatc gatggatgag atttgggact ttattcaagc
    16081 tgttgggcaa gatcgtgatc acttggctta tgatattgat ggagttgtta tcaaggtcaa
    16141 tagtttggcc atgcaggaag aacttggctt taccgttaag gcaccacgtt gggccattgc
    16201 ctataaattc ccagctgagg aaaaggaagc aaaacttctc tcggttgatt ggc
//
