LOCUS       gnlProkkaJLKCHBGE_38   11500 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|JLKCHBGE_38.
ACCESSION   gnlProkkaJLKCHBGE_38
VERSION     gnlProkkaJLKCHBGE_38
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2025-04-28 20:34:01
            Original ID  :: gnl|Prokka|JLKCHBGE_38
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 74610
            Orig. end    :: 86110
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..11500
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[5000:8155]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..8155
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..11500
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..11500
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             complement(168..1787)
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 111.6; E-value:
                     8.4e-34)"
                     /gene_kind="transport"
                     /locus_tag="ctg38_71"
                     /transl_table=11
                     /translation="MNTQQINFKWVVKHVPIYLQIVFLVLSAISAFEGVLNAVLFGQLT
                     NINFSNIDHVYKFIGLAFGAYLIVYIAMLLFYLVQNRIVMLLNIALKQEYFYSKFANSD
                     MKQARGADVINSISGTAKEIEQKYFFGITDIVQFVFNVVASAIVVVETNLILGIIYLLL
                     SALTLIPSYIGKKRMNEKTEKWNKSNSQLIQAMKDIFEGRLEILNFGVRHLFFKRFDRI
                     LVNEEDKYRKMNNCQFQVQFIAWLISLVTLLLPIFIGLLFMQRGWFNVTVAAIITLSLS
                     ADRVVGYLRTIALYQTQIHSTDAIRKIKSYNFEESESVKQDNHDSQAILKIKDLSFSYG
                     DKKILDGINLTLRDHDKIIVTGASGIGKSTLINCIANNLKYNGEITFAGHQINPADFIK
                     ISQRIWLFQGTVRENLSLLQNIPDDLMLHEAKKMGLIHEFGNDFLDKLISDDANNLSGG
                     QAQRLALVRGLIRSKKIYLLDEICSSLDPKNSDAIHKIIYQLPAIVIEIAHNYNPQLAQ
                     ENKVQVYKLIDAKLQKQNYIEQ"
     CDS             complement(1852..2022)
                     /locus_tag="ctg38_72"
                     /transl_table=11
                     /translation="MSEGMKKLIKDLSDGKNISLENIDALVNKYHLSLEERQLLETKDE
                     DDLKQLGLKSV"
     CDS             2184..3038
                     /locus_tag="ctg38_73"
                     /transl_table=11
                     /translation="MYGQKFKALRLQQHISLEQAANRVISPSTLSRWENNKIDIRFNLV
                     IKLLDNIHINLKEFTNYCKINHSNPFVAKVAMYYEANDDRHILQLIQSKKKEYQNSHNQ
                     FDLLLLASACNCYYDLTDNNVFPVSYQKKLFYILSNIEYWTEMYINVFGNTVFLYDSKE
                     LYSISIRILKNLNFNTFNDFQEYYYALSSVINALTALIIKNPKLASQLLTKIEKVSIPK
                     PISYLKIRTNVLKYLLDYRLGKTDEKLISIKLENLKWLGLTDIAKDLTFFFNRIKNDRS
                     PIS"
     CDS             complement(3184..3597)
                     /locus_tag="ctg38_74"
                     /transl_table=11
                     /translation="MKMEHSAGAVIYRRRVTGELEYLIVQSVVNHNWGFPKGHLENDEN
                     AEEAARREVFEEVGLKPEFDFNFKEKVKYQLTENKEKTVVYFIAKYLAGQEVKTQKEEI
                     LASKWVSLVEAQKYLTEHGKMDVLTKAQNYIEQ"
     CDS             complement(3774..4985)
                     /gene_functions="transport (smcogs) SMCOG1020:major
                     facilitator transporter (Score: 121.7; E-value: 6.3e-37)"
                     /gene_kind="transport"
                     /locus_tag="ctg38_75"
                     /transl_table=11
                     /translation="MRKLKLASSSVYLYLLGTFVSNLGDGIFTLIISKILYDKTGSVSA
                     FGLVLIIQNVASFLLNLLAGYIADIKKPQFISEIADSLRGIMIILGIIFLRLSNNIIVV
                     LMILMLILNLIVPFFRAANFKIIASIQRGGLGLLPLNGLRSSVNQSGQLLGVAIATPLI
                     AFNLTIPALLIDALTFFTSFICTIFLKFNKEHPVQIKVSDNKLKKMYFEWFKLLRTLFI
                     SKKLLLLVFFSSIDSVIVAFINLMEIKYATVVLKNSVYLTVLDGFFALGAMLNFTIIYL
                     LFERFNFSEVSWSGLFFQALAFIGLTLTSSIYIATIFIFIIGIFNGASQSLFQTQLHTS
                     FDETMKGKISSLRDAMVAFLNLIMIPVFSRLLNFNLYIAFWIFALCILVSSISVFLIFR
                     LKMF"
     CDS             complement(5001..5858)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 160.2;
                     E-value: 1e-48)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg38_76"
                     /sec_met_domain="phosphonates (E-value: 6.5e-86, bitscore:
                     280.3, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 8.2e-52, bitscore:
                     168.4, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNALKQKLNEGKLVRVIEAHDGLTAKMVDQAHSLKTNKQFDALWS
                     SSLCDSLVNGRPDMEVLSMDRRIAIINELRENSKKPIIVDMDSGGRLEQLFYKLKQLNE
                     INIEAIVLEDKIGTKRNSLFGEKNPQKQDTIEHFSKKITFVQENKNSDLMLFARIESLT
                     LGAGKYDAVKRAKAYIDAGADGILVHNANDSVEDLYYVIKKVKDYKDVPVIVVPTAFSF
                     VTEKELEQEGVNIVIYANQLIRSTIEPIAATLNSILDHGRAFEANKNLISIKEVLNFID
                     EPPI"
     CDS             complement(5866..6963)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1268:mandelate racemase/muconate lactonizing enzyme
                     (Score: 201; E-value: 4.2e-61)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg38_77"
                     /transl_table=11
                     /translation="MAIVKQFEIFKLSMPLSHAFVTNKRKSTDMNSLIFKAALSDGTIG
                     WGEAAENISLTGITIEGMLNFSCTLIKHILNEEINVALKLVSKSEYNSAKYGIETALID
                     AASQSQKTPISELLGISKPKSKIINDTTVSIMNSEETIRYTTNLVEQGYRYIKYKLGPG
                     TDEIARILQLSQYLSQDISIRIDPNQAWNKESALKYISLLQKSSLNVDLIEQPVGQQNL
                     TTLKELAQFSTIPIVADESVFGIQDAKKIINGKFADMLNIKLIKCGGPIEAVRIAKFAQ
                     KNNIKCMFGCTSEANIAITMAAYLASCLPNVIYYDLDGLDFISESPFSGGVVRDKDKLI
                     IPDGIGLEIQPNKNMKFLKLVKVLR"
     CDS             complement(6970..7536)
                     /NRPS_PKS="Domain: Aminotran_1_2 (15-175). E-value:
                     1.8e-23. Score: 75.1. Matches aSDomain:
                     nrpspksdomains_ctg38_78_Aminotran_1_2.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_1_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1019:aminotransferase (Score: 99.2; E-value: 4.1e-30)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg38_78"
                     /sec_met_domain="Aminotran_1_2 (E-value: 2.6e-23, bitscore:
                     75.1, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMYIAKLHLLEALSKNIQNRTIIAGGISKNYGMTGWRIGWLIGPE
                     EIISASSSFQSHSLGSAVTISQDAAISLLNHVDESPFNEIFSERRKTMVEELRKIKELT
                     FIEPQGACYIFPSIKKLVGKKYDGVILKNSKQFCELALKYGHISVIPGEACGLEGYLRL
                     SFGSLTSAQIKENMFQLKQFVENFR"
     aSDomain        complement(7012..7491)
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg38_78_Aminotran_1_2.1"
                     /evalue="1.80E-23"
                     /label="ctg38_78_Aminotran_1_2.1"
                     /locus_tag="ctg38_78"
                     /protein_end="175"
                     /protein_start="15"
                     /score="75.1"
                     /tool="antismash"
                     /translation="NIQNRTIIAGGISKNYGMTGWRIGWLIGPEEIISASSSFQSHSLG
                     SAVTISQDAAISLLNHVDESPFNEIFSERRKTMVEELRKIKELTFIEPQGACYIFPSIK
                     KLVGKKYDGVILKNSKQFCELALKYGHISVIPGEACGLEGYLRLSFGSLTSAQIKE"
     CDS             complement(7493..8155)
                     /NRPS_PKS="Domain: Aminotran_1_2 (34-216). E-value:
                     7.4e-40. Score: 129.0. Matches aSDomain:
                     nrpspksdomains_ctg38_79_Aminotran_1_2.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_1_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1019:aminotransferase (Score: 146.3; E-value: 2e-44)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg38_79"
                     /sec_met_domain="Aminotran_1_2 (E-value: 1.1e-39, bitscore:
                     129.0, seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 7.9e-12,
                     bitscore: 37.4, seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNIKENLSNRIKRVKPSVTNDSNRQAKELIKNGIHVFNLSNGDIS
                     LPTPEIAKNAAIEAIENDDTKYTLASGKEELRKAIADQYNRKYDLDYKYQNVLVGSGTK
                     NVLFTLMGVLCNHDDEIIVPTPCWPSYFEQIKLFGATPKIIECGIENNFKLTAKLLSKN
                     ITTRTKAVILNSPNNPSGSIYSKEELAELAKVLEKHDDIFIIFDDVYSEIASPRSSF"
     aSDomain        complement(7508..8053)
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg38_79_Aminotran_1_2.1"
                     /evalue="7.40E-40"
                     /label="ctg38_79_Aminotran_1_2.1"
                     /locus_tag="ctg38_79"
                     /protein_end="216"
                     /protein_start="34"
                     /score="129.0"
                     /tool="antismash"
                     /translation="HVFNLSNGDISLPTPEIAKNAAIEAIENDDTKYTLASGKEELRKA
                     IADQYNRKYDLDYKYQNVLVGSGTKNVLFTLMGVLCNHDDEIIVPTPCWPSYFEQIKLF
                     GATPKIIECGIENNFKLTAKLLSKNITTRTKAVILNSPNNPSGSIYSKEELAELAKVLE
                     KHDDIFIIFDDVYSEIASP"
     CDS             complement(8145..9347)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RimK"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Dala_Dala_lig_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg38_80"
                     /sec_met_domain="RimK (E-value: 5.6e-09, bitscore: 28.2,
                     seeds: 4, tool: rule-based-clusters)"
                     /sec_met_domain="ATP-grasp_3 (E-value: 2.8e-11, bitscore:
                     36.1, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="Dala_Dala_lig_C (E-value: 1.6e-12,
                     bitscore: 39.7, seeds: 12, tool: rule-based-clusters)"
                     /sec_met_domain="ATP-grasp (E-value: 4.2e-16, bitscore:
                     51.4, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKKVIVELGLHINQTPNFVKTARENDLNVYLIEGSTKIKNNKAL
                     VSLFDKTFIAENNDFEKINAWLKQQINIIGLISFEEDWLITTAKLNKSLNLLGTSLRSV
                     TQTINKVKTHELLAKAGIPTAEYKVVNTLAEARSFADIIGYPLILKPTNKKGSKGVIKV
                     KNEIELPQAFKECLSFCDNSQVLIEQYIKGNEFSLEGIVSSKGLCLFGITEKFLFPGTT
                     VEKMHITPLKKFSPKNMWNLANTVTNTLNISFGPFHIECFDAKDNVYVNEVHTRFGGDN
                     ITKITSLASNNNIHEILIKDLLKRPFEYTPIYSTDKTVAVSFIGAKTGTISELNLSILD
                     SKKVVLSDLRIKLHQKVKYPENSYDRLGWFIVKGIDRKDVLKKVLKIESAIEIKVKKDE
                     H"
     CDS             complement(9325..10572)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Dala_Dala_lig_C"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg38_81"
                     /sec_met_domain="ATP-grasp_3 (E-value: 4.3e-15, bitscore:
                     48.5, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="ATP-grasp (E-value: 2.2e-12, bitscore:
                     39.3, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Dala_Dala_lig_C (E-value: 1.8e-11,
                     bitscore: 36.3, seeds: 12, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKILFVGSMYDQKIGVLKEAKKMGLFVALMGNDYPSWGSKYIDL
                     YIKSNNYDSSDALEILDNLNLKFDGVVTFWDRDVELTSKIAEHFDLPGCPVKAATIMRN
                     KYLTRKVISKYKIPNIPYKLITDLSTLNSAIKKIGYPAIIKPVSASSSKGIFEINSEKD
                     IDEVKEKIIKTITPEKDKMFLYNKGKFIFEQFITGQEYSVESVIQNGNINIIGITEKIT
                     NNQFEEVQHTHPAPIDKNNEKRIKETVKKVLKAIGADNCTTHTEIKLTKEGPRIVEVNG
                     RMGGDYINTDLVPLARGINIVRATLQVSLNESIRDAISPKFNKGASVRFIIPSHAGTIK
                     SWKIDKELFKKKEFVKIHKDKKVGEKILFPPNAFHDTRAGYLIAKNSTAEKAKKNAQEF
                     VDKYVRIDMYDKKSNC"
     CDS             10696..11499
                     /locus_tag="ctg38_82"
                     /transl_table=11
                     /translation="MYGKYFKQLRKKQDISLKDAAANVISVSQLSRWENGRSNISFETV
                     INLLDNIHIRANEFIMYCKLNPTNSLTHKIFDAYQRKDITELEHLTLNQIKKSKTSKNR
                     FDLFLAVAAANFYFDLTNIRLISKFDILKVKSILSSTSYWDYYYISAWGNTLAFYNPAF
                     NFKIASRILTILKKRTPLEFGTEYYTWCTILNALIRIIPEKLELAKKLSLKIDRTSIPK
                     PFLSIRIKKRFMDIYIKYQLHESDKEELNKFFYSLENLQLIDLKNE"
ORIGIN
        1 cgatgaagaa cacccagaaa caccaatcca agatgaagct aagaagacct tggaagctat
       61 catcaaggaa ttgagctaat attaaggaaa taaattagtg tctcattcaa ttaaaattta
      121 atttcttaat gacgaaaaga cgagagttga ttaagctccc gtctttttta ttgctcaatg
      181 taattttgct tctgtagttt ggcatctatc agtttataaa cttgcacttt attctcttgt
      241 gcaagttgtg gattatagtt atgtgctatt tcaatgacaa tagccggcaa ttggtagatt
      301 atcttatgaa tggcatcact atttttaggg tctaaacttg aacaaatctc atcaagcaaa
      361 tatatcttct tagaacgaat tagacctcta actaaagcaa gtcgttgtgc ctgaccacct
      421 gataaattgt tcgcgtcatc tgaaattaat ttatctaaaa aatcattgcc aaactcatga
      481 atcagtccca tcttttttgc ttcatgaagc attagatcat caggtatgtt ttgcagaagt
      541 gatagattct ccctcactgt accttggaat aaccagattc tttgcgagat cttgatgaaa
      601 tcggcaggat taatttgatg accagcaaag gtgatttcac cgttatactt cagattatta
      661 gcaatacaat taattaatgt acttttccca atgcctgaag ccccagtaac aatgatcttg
      721 tcatgatcac gcaaagttaa atttatacca tctaaaattt tcttatcacc atatgaaaaa
      781 gacaaatctt ttattttcaa aatagcttga gagtcatgat tatcttgttt aacactttca
      841 ctttcttcaa aattatagct ttttattttt ctaattgcat cggtgctatg aatttgagtc
      901 tgatacaaag caattgttct tagatatccc acaaccctat cagctgacaa acttaaagtt
      961 ataatggccg ctaccgttac gttaaaccag cctctctgca taaaaagcaa gccaataaaa
     1021 attggtagca atagtgtaac taaagagatt aaccatgcaa tgaattgtac ctggaattga
     1081 caattattca tcttacgata tttgtcttcc tcattaacca agattcgatc aaatcgttta
     1141 aagaaaagat gtctgacacc aaaattcagt atttctaagc gtccttcaaa tatatccttc
     1201 attgcctgaa tcaactgtga gttagattta ttccattttt cggttttctc attcatcctc
     1261 ttcttgccaa tatagcttgg aatcagggtt agcgctgaaa gaagcaaata aataattccc
     1321 aaaatcagat tagtttctac aacaactatt gccgatgcaa ccacattaaa tacaaactga
     1381 actatgtcag ttatcccaaa gaaatatttt tgttcaattt ctttagcagt accactaatc
     1441 gaattgatta catctgctcc tcttgcttgc ttcatgtctg aattagcaaa tttagaataa
     1501 aaatattctt gctttaaagc aatatttaat agcatcacaa ttctattttg aaccaaataa
     1561 aacaagagca tggctatgta gactatcaga tatgcgccaa aggctaagcc aataaattta
     1621 taaacgtggt caatgttact aaaattgata ttagttaatt gtccaaacag tacagcattt
     1681 aatacccctt caaatgctga aatggccgat aaaaccagaa aaactatttg taaatatatt
     1741 ggaacatgtt ttactaccca tttaaaattt atttgttgtg tgttcattgt ttaataccca
     1801 catatttctc ataatcaaca agccaatctt catcattttt ataagaatga ttcatacact
     1861 ttttaaaccc aattgcttta aatcatcttc atctttagtt tctaacaatt gtcgctcttc
     1921 tagagacaag tgatacttat tcactaaggc atcaatattc tccaaagaaa tatttttacc
     1981 atcagaaaga tccttaatta atttcttcat accttcagac attactatac ctcctatttt
     2041 ctctcgttaa gtaatgcata attttcaact tgcaatttac tgtgtatggg attgatatca
     2101 atgcttccca taattcccca aatgcttata ataataacag taagtattct cttatttttt
     2161 aatttcaaag ccaggaattc attatgtacg gtcaaaaatt taaagcactt cgtcttcaac
     2221 aacatatttc actagagcaa gctgctaaca gagttatctc tccatcgact ttatccagat
     2281 gggagaataa taagattgat attcgcttca atttagttat taagctttta gacaatattc
     2341 atataaacct aaaagagttt actaattact gcaaaattaa tcatagtaat ccatttgttg
     2401 cgaaagtggc tatgtactat gaagccaacg atgatcgtca tattttgcaa ttaatacaaa
     2461 gcaagaaaaa agaataccaa aattcacata atcaatttga tttacttcta ctagctagcg
     2521 catgtaattg ttattacgat ctaactgata acaatgtttt cccagtgagc tatcaaaaga
     2581 aattattcta cattttatct aacattgaat attggacaga gatgtacatc aatgtttttg
     2641 gtaacactgt ttttctctat gacagcaagg aactatatag tatttcaatc agaattctta
     2701 aaaatttaaa ttttaataca tttaatgatt ttcaagaata ttattatgct ttatcctctg
     2761 tcatcaacgc cctaaccgct ctaattatca aaaatcccaa attagcatca cagcttttaa
     2821 ctaaaataga gaaagtttca attcctaaac caatctctta cttaaaaatt agaactaatg
     2881 tcctcaagta tcttttagat taccgtttag gcaaaacaga tgaaaagctt atctcaatta
     2941 agctagaaaa tttaaagtgg ttaggattaa cagatattgc aaaagactta actttcttct
     3001 ttaaccgtat aaaaaatgat cgttcaccta tttcctaatt catttgccta ttatattacc
     3061 ctcattttta tctaattgat ttttctttgc aaatatgcaa aattattttt agcaagaata
     3121 aaaaagccta ttaaatctag gtgtttacaa accctgattt aataggtctt ttatgcgtct
     3181 tttttattgc tcaatgtaat tttgcgcctt agttaaaaca tccatctttc catgctcagt
     3241 caaatacttt tgggcctcga ccagactcac ccacttgcta gctaaaattt cctctttttg
     3301 cgttttgact tcttgtcctg caagatattt ggctataaag tagacaaccg ttttttcttt
     3361 attctctgtt aattgatatt tgaccttttc cttaaagtta aaatcaaatt ccggctttag
     3421 tccaacttct tcaaagactt ctcttctagc cgcctcttca gcattctcat cattttccaa
     3481 atgccctttt ggaaagcccc aattatggtt cacgacgctc tgcacgatca aatattccag
     3541 ttcaccagtc acacgtcttc tgtaaataac tgcacctgca gaatgttcca ttttcatttt
     3601 tgtcacccaa cctttatatt gaacaattat taaatattta ttaatgtagg tcaagcgatt
     3661 gggatcaaaa aatgaccgtc ataaattgaa atatcctgat tttactaatt tcctttttaa
     3721 taataaacat aatttaaaaa atactatgaa gatacacgta ctaattattt atcttagaac
     3781 atttttaatc taaaaattaa aaatactgaa atactgctta ctaaaataca aagtgcaaaa
     3841 atccagaaag caatatataa attaaaattt aatagtcttg aaaacactgg aatcattatc
     3901 aaatttaaaa aggcaaccat agcatctctt aaactagaaa tttttccttt cattgtttca
     3961 tcaaaagatg tatgtaactg tgtttgaaac aaagactgcg atgcaccatt aaatattcca
     4021 ataataaaga taaagattgt agctatatat attgaactgg ttagagttag cccgataaaa
     4081 gccaaagctt ggaagaataa accagaccaa gaaacttcag agaaattaaa tctttcaaat
     4141 agtaaataaa tgattgtaaa atttaacatt gcacctagtg caaaaaatcc atctaaaaca
     4201 gttagataaa cggagttctt taatacaact gttgcatatt ttatctccat taaattgatg
     4261 aaagcgacaa ttactgaatc gatcgaagaa aaaaacacta acaaaagtaa ctttttgctt
     4321 ataaataaag ttcttaatag cttgaaccat tcaaaataca ttttctttaa cttattatct
     4381 gaaactttaa tttgaactgg atgttcctta ttaaatttta aaaaaatagt acaaataaat
     4441 gaagtaaaaa aagtaagtgc atctatcaat aaagcaggaa ttgttaaatt aaatgcaatt
     4501 aaaggtgtag caatagccac acctaataat tgaccacttt gatttactga actacgtaac
     4561 ccattcaatg ggagtaatcc caaaccacct ctttgaatac tagcaatgat tttaaaatta
     4621 gccgctctaa aaaatggcac aatcaagttt aaaatgagca ttaatatcat taaaactacg
     4681 attatattat ttgataatct taaaaagata atacctaaaa taatcataat tccgcgtaag
     4741 ctgtctgcaa tttctgaaat aaattgtggc tttttaatgt cagcaatgta accagctaat
     4801 aaatttagca aaaaagatgc tacattttga ataattaaca ctaatccaaa agccgaaacc
     4861 gagccagttt tatcatacaa aattttagaa attatcagtg taaaaatccc atcacccaga
     4921 ttcgacacaa aagttccaag tagatataag taaactgaag atgacgctag ttttagcttt
     4981 ctcattaaag ccacctccgt ctaaatcggt ggctcatcta taaaattcag aacctcttta
     5041 attgaaatta aatttttatt tgcttcaaat gctcgtccat gatccaaaat agaatttaaa
     5101 gtagctgcta taggctcaat tgtacttcta attaattgat tagcataaat gacaatattt
     5161 acaccttctt gctctaattc tttttctgtt acaaatgaaa atgcagtagg aacgactata
     5221 acaggtacat ccttataatc cttaactttc tttataacat aatatagatc ttcaacagaa
     5281 tcatttgcat tatgaaccag aattccatca gctcctgcat caatataggc cttagctctt
     5341 tttacagcgt catatttacc tgcacccaat gttaaacttt caattcttgc aaataacatt
     5401 aaatcactat tcttattttc ttggacaaaa gtaattttct tagagaagtg ttcaattgta
     5461 tcttgttttt gaggattttt ttcaccaaat aaagaatttc ttttagttcc aattttatct
     5521 tccaaaacta tggcttcaat gtttatttca tttagctgtt ttagtttata aaataattgt
     5581 tctaaacgac ctccactgtc catatccact ataataggct ttttactatt ttctcttagc
     5641 tcattaataa tagcaattct cctatccata cttaaaactt ccatatccgg ccttccattt
     5701 accaaagaat cacataatga gcttgaccat aaagcgtcaa attgcttatt agtctttaat
     5761 gaatgagcct gatcaaccat cttagcagtt aatccatcat gagcttctat aaccctaaca
     5821 agctttcctt cgtttagttt ctgcttcaat gcattcataa aggtatcacc tcaatacttt
     5881 aactaatttt aaaaatttca tgtttttatt aggctgaatc tctaatccaa taccatctgg
     5941 aattattaat ttatccttat ctctgacaac accaccacta aaaggtgatt cagaaataaa
     6001 gtctagtcca tccaaatcat aataaatgac attaggtaaa catgatgcta aataagctgc
     6061 catagtaata gcaatatttg cctcagaagt gcagccgaac atacatttta tattattttt
     6121 ttgtgcaaat tttgctattc tgaccgcctc aattggaccc ccacatttta ttaatttaat
     6181 atttagcata tcagcaaatt taccattaat tattttctta gcatcttgaa ttccaaatac
     6241 cgattcatct gccacaatag gaatagtact aaattgagct aattctttta atgtcgttaa
     6301 attttgttgt ccaactggct gttcaattaa atctacattt aaagaacttt tctgtagtaa
     6361 actaatatat tttaatgctg attccttatt ccaagcttga tttggatcaa ttcgaattga
     6421 aatatcttgg gataaatatt gtgacaactg taatatgcgc gcaatctcat ctgtacctgg
     6481 acctaattta tactttatgt atcgatatcc ttgttcgacc aagttagttg tatatctgat
     6541 tgtttcttca gaattcataa tacttactgt cgtatcattg ataattttac tttttggttt
     6601 agagatacca agtaattctg aaattggagt tttttgagat tgagaggctg catcaattaa
     6661 agctgtttca attccgtatt ttgctgaatt atactcactt ttacttacta acttcagggc
     6721 tacatttatt tcttcattca aaatatgctt aattaaagta catgaaaagt tgagcatacc
     6781 ttcaatagtt attcctgtta agctaatatt ttctgctgct tcaccccatc cgatcgttcc
     6841 atctgacaaa gcagctttaa aaattaaact attcatatca gttgatttac gtttatttgt
     6901 cacaaaagca tgactcaatg gcattgataa tttaaaaatt tcgaattgct ttactatggc
     6961 catacgtgat cacctgaaat tttctacaaa ttgttttaat tgaaacatat tttccttaat
     7021 ttgcgcagaa gttaaactac caaatgaaag acgaagataa ccctctaatc cacatgcttc
     7081 tccaggaatt actgaaatat gtccatattt taatgcaagt tcacaaaatt gttttgaatt
     7141 ttttagaatt acaccatcat attttttacc tacaagcttc ttgatagacg gaaatatata
     7201 acatgcacct tgaggctcaa taaaggttag ttcctttatt tttcttaatt cttcaaccat
     7261 tgtttttctt ctttcagaaa aaatttcatt aaatggagat tcatcaacat gatttaacaa
     7321 actaatagct gcatcttgag aaatagttac cgcgcttcct aaactatgac tttggaatga
     7381 gctagaagca gatataattt cttctggacc aattaaccaa ccaattctcc aacctgtcat
     7441 accataattt tttgaaattc ctcctgcgat aatagttcta ttctgtatat ttttagaaag
     7501 agcttctagg agatgcaatt tcgctatata catcatcaaa aataataaag atatcatcat
     7561 gtttttctaa taccttagct aattctgcta gttcttcctt cgaatatatc gatcctgagg
     7621 gattattagg tgagttaagt attactgctt tagtcctagt agtaatattt ttgcttagta
     7681 attttgctgt taatttaaaa ttattttcaa tcccacattc tataatttta ggagttgctc
     7741 caaataactt tatttgctca aaatatgatg gccaacaagg tgtaggaact attatttcat
     7801 catcatgatt acaaagtact cccattaatg taaaaagaac attcttagtt ccagatccaa
     7861 caagaacatt ttgatattta taatctaaat catattttcg attatattgg tcagcaatcg
     7921 ctttacgtaa ttcttctttt cctgatgcca aagtatattt tgtgtcatcg ttttcaatag
     7981 cttcaattgc tgcgttttta gcaatttcag gagttggcaa cgaaatatca ccattactta
     8041 aattaaatac atgaatacca tttttgatta attcttttgc ttgtctgttg ctatcgttag
     8101 ttacagatgg cttgactctt ttaatacgat ttgaaagatt ttctttaatg ttcatctttt
     8161 ttcaccttta tttctattgc tgactcaatc ttcaatactt tctttaaaac atcttttctg
     8221 tctatccctt ttacgataaa ccaacctaat ctgtcataac tattttcagg gtatttaact
     8281 ttttgatgta gtttaattct taaatcactc agcactactt ttttcgaatc taaaatcgac
     8341 aaatttaatt ctgaaatcgt tcctgttttt gcaccgataa aagaaacagc aacagtctta
     8401 tcagtagagt aaattggtgt atattcaaaa ggccttttca ataaatcttt tattaatatt
     8461 tcgtggatat tattattact tgccagactg gttatcttgg taatattatc tccaccaaat
     8521 ctagtgtgaa cttcatttac atatacattg tccttggcat caaagcattc tatatgaaac
     8581 ggcccaaaag atatatttaa agtgttagtt acagtatttg ccaaattcca catatttttg
     8641 ggagaaaatt tctttaacgg agtaatatgc atcttttcga cagttgtacc aggaaacaaa
     8701 aacttttcag taattccaaa caaacataat ccttttgaac ttacaattcc ttcaagggag
     8761 aattcatttc ctttgatata ttgttcaata agaacttgag aattatcaca aaaacttaag
     8821 cattccttga atgcttgagg caattcaatc tcattcttaa cttttatgac tcccttactt
     8881 ccctttttat tagtaggttt taggattaat ggatatccaa ttatatccgc aaaggaccgc
     8941 gcttctgcta aagtatttac taccttatat tccgctgttg gaattccagc ttttgccaat
     9001 aattcatgtg tttttacttt atttatcgtt tgagttacag aacgaagtga agtacctaaa
     9061 aggttaaggc ttttattcaa tttagctgta gtaattagcc aatcttcttc aaaagatatt
     9121 agcccaatta tatttatttg ttgctttaac caagcattaa ttttttcaaa gtcattattc
     9181 tcagcaataa acgttttatc aaagagtgaa actaatgctt tattgttttt gatctttgta
     9241 cttccttcaa ttaaataaac attcaagtca ttttctcttg ctgttttaac aaaattggga
     9301 gtctgattaa tatgaagtcc caattcaaca attacttttt ttgtcataca tatcaatcct
     9361 tacatattta tccacaaact cttgggcgtt ctttttagct ttttcagctg ttgagttttt
     9421 agcaattaaa tatccagctc tagtatcgtg aaaggcatta ggtggaaaca gaattttttc
     9481 tccaactttt ttgtctttat gaatttttac aaattctttt tttttaaata attctttatc
     9541 tattttccat gattttattg ttccagcatg agaaggaata ataaatctta cagaagcacc
     9601 tttattgaat ttaggactta ttgcatctct gatcgattca tttagagata cttgtaaagt
     9661 agctctaact atatttattc ctctagctaa aggaactaaa tctgtattaa tatagtctcc
     9721 gcccatacgc ccgttaactt ctacaatacg tggaccttct ttcgttaact ttatctctgt
     9781 atgtgttgtg cagttatctg ccccaattgc tttaagaact tttttaactg tttcttttat
     9841 ccgtttttca ttatttttat caattggtgc tggatgagta tgttgaactt cttcaaactg
     9901 attatttgta attttctccg ttattccaat aatatttata tttccatttt gaattacaga
     9961 ctcaacacta tattcttgac cagtaataaa ttgttcaaat ataaattttc ctttgttata
    10021 taaaaacatc ttatcttttt ctggtgtaat ggttttaatg attttctctt tgacctcatc
    10081 aatatctttt tcactgttta tttcaaaaat tcccttcgag gaagaagcac ttacaggttt
    10141 tatgatagcc ggataaccaa ttttctttat tgcactattt agagttgaca aatctgttat
    10201 caacttataa ggtatatttg gaattttata tttgctaatt actttacgag ttaaatactt
    10261 atttctcata atagtagcag ctttaactgg acatccaggt agatcaaaat gttctgcaat
    10321 ttttgaagtc aattcaacgt ctctatccca gaaagttaca actccatcaa atttaagatt
    10381 taaattatct aaaatttcaa gagcatcaga agagtcatag ttatttgact ttatatacaa
    10441 gtcaatatat tttgaccccc acgatggata gtcatttccc attaatgcta caaataatcc
    10501 cattttttta gcttctttaa gtacaccaat tttttgatcg tacattgatc cgacaaaaag
    10561 aatttttttc ataaaaaaca cctcattcta acgaaaaaat ttttccaaga acattggaac
    10621 tacaatcaat gccccttcta caagaaagga aataataact ttaatcattc tttttttatt
    10681 catggtaaga acctcatgta tggtaaatat tttaaacaat taagaaaaaa acaagatatt
    10741 tctttaaaag atgctgctgc aaatgtaatc tcggtttctc aattatccag atgggaaaat
    10801 gggagaagta acatttcttt tgaaacagta atcaatcttt tagataacat tcatattcga
    10861 gcaaacgaat ttataatgta ctgtaaactt aatccaacaa actctttaac tcacaaaata
    10921 tttgatgctt atcagagaaa agatattact gagcttgaac atctaacttt aaatcaaatt
    10981 aagaaaagta aaactagtaa aaacaggttt gatttgtttc tagccgtagc tgctgctaat
    11041 ttttattttg atttaaccaa tattcgttta atctcaaagt ttgatattct aaaagtaaaa
    11101 tcaattttat cgtctacttc atactgggat tattattaca ttagtgcttg gggtaatacc
    11161 ttagcattct ataatcctgc atttaatttc aaaattgctt caagaatact tacaattttg
    11221 aaaaaacgaa cgccattaga atttggtaca gagtattaca cttggtgcac tatcttaaat
    11281 gctctaatta gaataattcc agagaaactt gaactagcaa aaaaactttc actcaaaata
    11341 gatagaactt caattcctaa acccttttta tctattcgaa ttaagaaaag atttatggat
    11401 atatacatta agtatcagct acatgaatca gataaagagg aactgaataa atttttttac
    11461 tcattagaaa atttgcagtt aattgattta aagaatgaac
//
