LOCUS       c00178_gnlPro..        15421 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|MODKOLNA_178.
ACCESSION   c00178_gnlPro..
VERSION     c00178_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2025-04-30 22:21:43
            Original ID  :: gnl|Prokka|MODKOLNA_178
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 48018
            Orig. end    :: 63439
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15421
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[58018:61263]"
                     /cutoff="2000"
                     /detection_rule="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /neighbourhood="10000"
                     /product="Pyruvate2acetate-formate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..13245
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="2000"
                     /detection_rule="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /neighbourhood="10000"
                     /product="Pyruvate2acetate-formate"
                     /protocluster_number="1"
     cand_cluster    1..15421
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /kind="single"
                     /product="Pyruvate2acetate-formate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15421
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Pyruvate2acetate-formate"
                     /region_number="1"
                     /rules="((PFL_acetate1 or PFL_acetate2) and Radical_SAM)"
                     /tool="gutsmash"
     CDS             889..1413
                     /locus_tag="ctg178_46"
                     /transl_table=11
                     /translation="MTTIAAVRKDGVTALAGDGQVTLGEKVIMKGNAQKVRRIYHDQVV
                     IGFAGGVADAFTLQDWFEKKLEHYAGNLRRSAVALAQDWRKDPTLQKLEAMMIVMDEHD
                     LLLVSGSGEVIDPDEDVVAIGSGGNFAQAAAIAMLRHAPDMTPADIAKEAVNIAGNIDI
                     FTNHNVIVESF"
     CDS             1457..2866
                     /locus_tag="ctg178_47"
                     /transl_table=11
                     /translation="MAEVQTPKQIVEKLDQYVIGQDDAKRAVAVALYNRYRRMQLSPKM
                     QEEITPKNLLMIGPTGVGKTEIARRLAKIVEAPFVKVEATKFTEVGYVGRDVESMVRDL
                     AETAVAMEEEKQFSKVRIRAEKEANKRLVKILVPAIRKEKNTNPMAEMMSMLQGMQNGK
                     MPAGDDADAGGEVTDDIRNKRLSVAEQLEKGLLEDHEITVAVNDEKKGGGMGDMYGQMG
                     IDLSDTIGALMPKKKVERTMTVKEAREIFIKEESDKLVNHADIYHDAIQSAENNGIIFI
                     DEIDKIAAGNKHNSGEVSREGVQRDILPIVEGSQINTKYGPINTDHILFIGSGAFAEAK
                     PSDLIAELQGRFPIRVELKDLTEKDFVRILTEPDNALIKQYIALIGADGVKITFTKEAV
                     DRIAEIATQVNHDTDNIGARRLATILEKLLEDVLYEGPDMAMGSVTVTQQYVDDKIGHI
                     AADSNMTRYIL"
     CDS             2902..3780
                     /locus_tag="ctg178_48"
                     /transl_table=11
                     /translation="MVTIANDFLTVKISRHGAELTSIKDNLTGRERLWQADPAVWGRHA
                     PVLFPIVGALADNQYHYAGKTYHMGQHGFARDRDFTVLSATPFKASFVLKDDDKTRAMY
                     PFAFRLIITFALENNNLHVTYHVDNPDKSEPLFFSIGGHPGFKVPMTPDTQFSDYYLNF
                     KPRKSLVQIPLVAGEGIDYTHRTLAATDANLALTHETFDHDALIFALLGKTTFNLVSDK
                     TKHGVSVTMTDTPYLGVWSPYPTTGDFVCIEPWWGIADTIGSTGDLTRKLGINRLEPGT
                     AFEKGYMISIF"
     CDS             complement(3862..4569)
                     /locus_tag="ctg178_49"
                     /transl_table=11
                     /translation="MYVRFILLTYHSKVKNAKIVSSLRGGAHLILVLCFILAYFIGAIP
                     FGVVIGKLFYHTDIRKGGSHNIGTTNAYRMLGPVGGSIVLVLDILKGTLAASLPILFGI
                     EHHWLVLIVGLAAVFGHTFSIYIRFKGGKAVATSAGILLAYNPPFFVIAFAIWFSLILL
                     TSMVSVASTLGMVLITAWSLVYHDWLLTTVACGLLVVFLIKHRANFKRIKAGDENMVPF
                     GLGQYLRQHRGRS"
     CDS             5286..7298
                     /locus_tag="ctg178_50"
                     /transl_table=11
                     /translation="MDKATQAYNDSSIQVLHGLEAVRKRPGMYIGSTDGRGLHHLVYEI
                     VDNSVDEALAGFGDEINVTIHADNSVTVQDHGRGMPTGMHPSGKPTIEVILTVLHAGGK
                     FNQNSYKTSGGLHGVGSSVVNALSESLTVRVVRDKHAFEEHFINGGHPDGSLQKLGKVN
                     EPNGTTITFKPDPTIFQTTVFSYDTLAERLRESAFLLKNITINLTDERTGKHDSYHYPD
                     GLVSFVKYLNEGKDALSQVINFEGKKDGIVVDFAGQYNDGYSENLISFVNNVRTGDGGT
                     HEIGLRSGMTRAFNEFARKVGLLRERDKNLEGSDVREGFAGILSVRIPEEILQFEGQTK
                     GKLGTPQARTVVDGIVYDKLSTFLMENGEESQELVRKAVKARDAREAARKARDDSRTGR
                     KRKKDQGLLSGKLTPAQTKNPKRNELYLVEGDSAGGSAKQGRDRKFQAILPLRGKVLNT
                     QKAKLQDIVKNEEINTMIYTIGAGVGADFDLQQANYDKIIIMTDADTDGAHIQILLLTF
                     FYRYMRPLIDAGRIYIALPPLYRLQKGAGAKTKISYAWTDEELAKETKAMGKGYTLTRF
                     KGLGEMNADQLWETTMNPETRTLIRVRIDDAQLAERRVTTLMGDRVEPRREWIEHNVKF
                     DMDDDGSILETPTANHEKLQFGAKQIVKQLDKKGK"
     CDS             7305..9749
                     /locus_tag="ctg178_51"
                     /transl_table=11
                     /translation="LANQIQELTLEEVMGDRFGRYSKYIIQERALPDVRDGLKPVQRRI
                     LFAMNQDGNTYDKGFRKSAKSVGNVMGNYHPHGDSSIYEAMVRLSQDWKLRAPLIQMHG
                     NNGSMDGDPPAAMRYTEARLSKISKEMLADIDKETVDMVLNFDDTAQEPTVLPAGFPNL
                     LVNGATGISAGYATEIPPHNLREVIAAVLYLLKHPTADLDTLMQYVKGPDFPTGGIIQG
                     LDGIKQAYETGRGKIVVRSRTHIETIRGGREKIVVTEIPYDVNKAQMIKKIDELRINKK
                     VDGIAEVRDESDRFGLSVVIELKKEADAHGILNYLFKNTDLQIAYNFNMVAIADMQPKL
                     LGLKAMLEAYVEHRRDVVTRRTRFDLNKAAARQHIVEGLIKMLSILDQVIAAIRASKDK
                     GDAKRNLVKKFDFSEAQAEAIVSLQLYRLTNTDITALQKEAAQLAKAIAEYQDILARPA
                     ARDRVIEGELKRIAKEYGDDRRSSIQAKIETLEVATTVTVADETVMVQVSRDGYVKRSS
                     LRSYQAVDPADNGLKANDLAIFTGELSTLQHLYIVTNAGNVIYRPVHEISDARWKDTGE
                     HLSQTVGLGTDEKVLAVFAFDQLDGAGSFVLGSSDGYIKQTALSDLQPQRTYKSKPMMA
                     MKLKDPAAIVTNAYFTTDQQQDVFVVSRHAYGLTFPLSDVSTVGARATGVKSMDLKPDD
                     EVVNFILVKDPTTAKVGILTQRGAFKKMALSEVGEMSRARRGLLVLRELKRDPHRIVAM
                     MSVDDATRLNVLTDTGKVTTLNPAQHPAGDRYSNGSFVIDTDVLGKPVFVQTKEEPADQ
                     VE"
     CDS             10001..12262
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Pyruvate2acetate-formate: PFL_acetate2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Gly_radical"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg178_52"
                     /sec_met_domain="Gly_radical (E-value: 2.2e-41, bitscore:
                     132.6, seeds: 99, tool: rule-based-clusters)"
                     /sec_met_domain="PFL_acetate2 (E-value: 9.3e-244, bitscore:
                     802.0, seeds: 33, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKQLDETKVPNYWEGFNGGDWQEEINVRDFIEHNLNQYDGDESFL
                     AGPTEATTVLNNQVLNLKKQERANGGVLDADNNIPSTITSHGPGYLNKDLEKIVGVQTD
                     KPFKRAFMPFGGIRMAEDALESYGFKTDPQEHKIFNEYRKTHNQGVFDAYTPDMRKARH
                     YKIVTGLPDAYGRGRIVSDFPRIAVYGIDRLMAEKFKDYNLTGDGEMTDDVIKLREEIN
                     EQYRALNDMKKMAKEYGYDISRPAANAQEAVQWIYFGYLAAVKTQNGAAMSVGRIDTVI
                     DAYIQRDMRLGKLNEEQAQELIDHLVMKLRMVRFIRTEEYNSLFSGDPIWATLSLAGMG
                     NDGRHHVTKTAFRFLKTLDNMGAAPEPNITLLWSERLPEGFKRYATEVSIQSSTIQYEN
                     DDLMRNEWGTDYYGIACCVSAQPIADGVQYFGARANLAKTVLYAINGGKDEIQEAQVGP
                     EYAPITSDYIDYKEFMNKFDKMMDWLADTYVNALNVIHYMHDKYYYEAAQLALKDTQLN
                     RTFATGISGLSHAVDSISAIKYGHVKAIRDENGVAVDFVADNDDYPRYGNNDDRADDIA
                     KWLVKTFYNKMNTHHLYRGAKLSTSVLTITSNVVYGKNTGTTPNGRQKGEPFSPGANPA
                     YGAEKNGALASLMSTAKIPYHYATDGISNTFGVTPNTLGHDDETRKDTLVHMVDGYMEN
                     SGMHLNINVFNKETLIDAQKHPEEYPTLTVRVSGYCVYFADLTKEQQDDVIARTFFEEM
                     "
     CDS             12394..13245
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Pyruvate2acetate-formate: Radical_SAM"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1015:4Fe-4S single cluster domain (Score: 65.2;
                     E-value: 2.4e-20)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg178_53"
                     /sec_met_domain="Radical_SAM (E-value: 1.4e-25, bitscore:
                     82.4, seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLIDQSQSPLNILEQVGQDHDGPIKGYVHSVESFGSVDGPGIRF
                     VVFMQGCRMRCQYCHNPDTWNIGVGEEMTADQILADAQRYKAFWGDQGGITCSGGESLV
                     QIDFILELFTKAKALGISTCLDTSGGPFTRDQPWFGQFEKLMAVTDISLVDIKHIDSAE
                     HKKLTGFPNENILDMVQYMSAHGDDMWIRHVLVPERTDFDPYLKRLGDYIATLDKNVVQ
                     KVEILPYHTLGVKKYHELGITYPLEGIEPPSADRVKNAENLLHVKDYTGWQSWRPKPVA
                     SN"
     CDS             13370..14338
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LysR_substrate"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HTH_1"
                     /gene_functions="regulatory (smcogs) SMCOG1012:Bacterial
                     regulatory helix-turn-helix protein, lysR family (Score:
                     60.8; E-value: 3.2e-19)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg178_54"
                     /sec_met_domain="LysR_substrate (E-value: 3e-26, bitscore:
                     83.9, seeds: 361, tool: rule-based-clusters)"
                     /sec_met_domain="HTH_1 (E-value: 2.8e-19, bitscore: 60.8,
                     seeds: 1330, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTKQERIFSSKTLTYFLQLAETMNYTQAAQLLGITQPALTQQIK
                     KLERTVGAPLFYSVGKKLHLSDAGQTMLKSTHEIYEILNQTTDEIQQTTSATVGKINIG
                     LLSSIEDSAFIAFIAHYYQLNPEVEVTLRMMTRHEIWESLENNQIDLAIMNLPDETIKN
                     WKPYASKKIIDEQLLFLHHDDALANRKRIHFKDTLAEPWSTYPDDYFLGQLLREAYKNQ
                     MVDFPHVVAHFTTPYQLTQFVNLSGVNTALPTSFVRARADQIKAYAIAFDPAIRFEISF
                     VYRKEKADIPRISNFFQTFDDYLKEKDYLSRVSENRVKLDK"
     CDS             14368..15300
                     /locus_tag="ctg178_55"
                     /transl_table=11
                     /translation="MTTLIFGHQNPDTDAITSAMSWAEFQKQAGNTDVEAVALGGPNDE
                     TKFVLDHFKVQAPRVIKTAANETDHVMLVDHNEFQQSVSDIEDVTIDSVVDHHRIANFH
                     TAAPLFYRAEPVGSTNTVIFEMFQEYGFKISPTLAGLMASGLISDTLLLKSPTATDKDK
                     KILPEMAKIAGIDLQSYGLAMLKAGTNLAAKSDMDIIEGDAKSFTMGGKSIRIGQVNTV
                     DLNDIYARQDELISAMTKEAQAKGYDDFLLIATDILDSNSTGFAVGADRDKIASAFNEQ
                     FDKDARLALPGVVSRKKQVVPPMQSTFEG"
ORIGIN
        1 gaattgatgt cgtcaaacgc aacccatttg agctggttga attaaaaaag cagcatcatc
       61 atttaccaca atttttctat gaagccgaga ttcaggaact gttcaagaca gttgctggca
      121 aaaccccgct ggatcaacgt aatcgcgctt tgttggaagt tttgtatggc accggtattc
      181 gagtttccga gtgtgccaaa ctgacattga atcaggtcga tttcaatacg gcattactgt
      241 tgattcatgg taaaggcaac aaagataggt atgtgccctt tggacagtac gctcagcaag
      301 cactacgaac ttatttaaaa gatggccgac aagtcttgat ggctaaaagt caggcacagc
      361 atcgatatgt attcgtgaac cagtatgggc gtccgattac ctcgcgtggc attgaatata
      421 ttttggatca gctcatcaag cagacgacgc tgacagctaa cattcatccc cacatgctgc
      481 ggcatagttt tgcaacccat atgctggatc atggtgctga cctgcgaact gttcaagagc
      541 tactgggtca tgcaagttta tcaaccacac aaatctacac gcatgtcacc atggcacatt
      601 taaaaaatga gtatatgaaa tattatccga agcataatta agactaaagc atgatgcaaa
      661 agcagtctga gttttttaag ctaagaacat tggcgataac agattaatcg ctactttagc
      721 tgtttttatc cgacgagata cgcagataac gcgctcgcag tcgcagaaac ctacacataa
      781 tgacctgcaa gcctaaatag ccaaaattca gccatttagg cttgcagccc acttatgctc
      841 cggtttctaa gcgcttctgc tcgcgctcac ttaaaaagga gcatgactat gacaacaatt
      901 gcagcagtaa gaaaagatgg tgtgaccgct ttggccggtg acggtcaggt aacccttggc
      961 gaaaaggtca tcatgaaagg caacgcgcag aaagttcgcc ggatctatca tgatcaagtc
     1021 gtcatcggat ttgccggcgg ggtggcagat gctttcaccc tgcaagactg gtttgaaaag
     1081 aagctggagc attatgctgg caacttgcga cgttccgcag ttgcgctggc tcaagattgg
     1141 cgcaaggatc cgaccttgca gaaacttgaa gccatgatga tcgtgatgga tgagcatgac
     1201 ctgttacttg tatccgggtc tggcgaagtg atagatccag atgaagacgt ggtagcgatc
     1261 ggctccggcg gcaactttgc gcaagccgcg gcaatcgcga tgctgcggca tgccccagat
     1321 atgacaccag ctgacattgc caaagaagca gtgaatatcg cagggaatat cgatattttc
     1381 acaaaccaca atgttattgt cgaaagcttt tagtttgtaa ccgtcggcaa ttacattgac
     1441 ctacaggagg cttatgatgg cagaagtaca aaccccaaaa cagatcgttg aaaaactcga
     1501 tcaatatgtc attggacaag atgatgcaaa acgggccgtc gcggttgcct tgtataaccg
     1561 ttatcggcga atgcaattat cgccaaaaat gcaagaagag attaccccga aaaacttact
     1621 gatgatcgga ccaaccggtg tcgggaaaac cgaaattgca cgacgactgg cgaaaatagt
     1681 tgaggcgcca tttgtgaagg tggaagcgac taagtttacg gaagttggct acgttggccg
     1741 tgatgtcgaa tccatggtcc gagatcttgc cgaaactgcc gttgccatgg aagaagagaa
     1801 gcaattttca aaggttcgca tacgtgccga aaaagaagcc aacaagcgtt tggttaaaat
     1861 tttagtgccg gccattcgta aggaaaagaa taccaatccg atggccgaga tgatgagcat
     1921 gttgcaaggg atgcaaaatg gcaaaatgcc agctggcgat gatgcagatg caggcggcga
     1981 agtgaccgat gatattcgca ataagcgttt gagcgtggca gagcaactgg aaaaaggatt
     2041 acttgaagat catgaaatca ccgttgctgt caatgatgag aaaaaaggcg gtggcatggg
     2101 tgacatgtac ggtcagatgg gcattgatct aagcgacact attggcgctt taatgcctaa
     2161 gaaaaaggtt gagcggacca tgaccgtcaa agaagctcgc gaaatcttca tcaaagagga
     2221 atctgacaaa ctggtcaatc atgccgacat ttatcacgac gccattcaaa gtgccgagaa
     2281 taacgggatc attttcatcg atgaaatcga taaaattgct gcaggaaaca agcataatag
     2341 cggcgaagtt tcgcgtgaag gtgtgcagcg agatatttta ccgattgtag aaggatcgca
     2401 gattaacact aagtatggtc ctatcaatac ggatcacatc ttgttcattg gctcaggtgc
     2461 gtttgccgag gctaagccta gtgatttgat tgctgaactt caagggcgtt ttccaattcg
     2521 ggttgaattg aaggacttaa ccgaaaaaga ctttgtgcgg atcttgaccg agccagacaa
     2581 tgctttgatc aagcagtata tcgccttgat tggtgcagat ggcgtgaaga ttaccttcac
     2641 gaaggaagcg gttgatcgaa ttgcagagat tgcgactcag gtcaaccacg acactgataa
     2701 tattggagcg cggcgactgg caaccattct tgaaaaactg cttgaagacg tactttatga
     2761 aggtccagat atggcgatgg gcagtgtgac cgtcacccag caatatgtgg atgacaagat
     2821 tggccatatt gcggctgatt caaacatgac gcggtatatt ttgtagttaa caataatgtt
     2881 gtaggtaaag gatgaggatg tatggtaacg attgcaaatg actttttgac agttaaaatc
     2941 agtcggcatg gtgctgaact gaccagtatc aaagataacc tgacaggcag ggagcgtctg
     3001 tggcaagcag atcctgcggt gtggggtcgc cacgccccgg tcttgttccc gattgttggg
     3061 gcgctggctg acaatcaata tcattacgca ggcaagactt accacatggg ccagcacggt
     3121 tttgcccgtg atcgtgattt cacggtgctc tctgcgacac cgtttaaagc gagcttcgtt
     3181 ctgaaggatg atgacaaaac gcgggcgatg tacccgttcg cttttcgttt aatcatcacg
     3241 tttgcactag aaaataacaa tctacatgtc acgtatcacg ttgacaatcc ggacaaaagt
     3301 gagccactgt tctttagcat cggcggccat ccgggcttca aggtcccaat gacgccggat
     3361 actcaattct ccgattatta tttgaacttc aaaccgcgta agtcgcttgt tcagattcca
     3421 ttggttgctg gtgaaggcat tgattacacg caccggacct tggctgcaac tgatgccaat
     3481 ttggccttaa cgcacgaaac atttgatcat gatgctttaa ttttcgcgtt gcttggtaag
     3541 acaaccttca acttggtttc tgacaagacg aaacatggtg tcagcgttac catgaccgat
     3601 accccatatc tgggcgtttg gagtccgtat ccaaccactg gcgactttgt ctgcatcgaa
     3661 ccttggtggg gcatcgccga cacgattggc agcactggcg acctgacgcg caaactcggg
     3721 atcaatcgac ttgaacctgg cacggcattt gagaagggtt acatgatcag cattttctaa
     3781 ggtgtcatca gtttgtcgat taggtacatg aaaaaaagac atccagtttc ggatgtcttt
     3841 ttggttgcca tcaaaaggtg actaagagcg gccccggtgt tgacgaagat attggcctaa
     3901 gccaaagggc accatatttt catctccggc cttgatgcgt ttgaagtttg cccgatgttt
     3961 gatcaaaaag acaaccagca acccgcaggc aacagttgtc agcaaccaat catggtaaac
     4021 aagcgaccaa gctgtgatca acaccatacc cagtgtgctg gcaacgctga ccatggacgt
     4081 tagcaagatc aaactgaacc agatggcaaa tgcaatgaca aaaaatggcg gattatatgc
     4141 aagtaaaatg ccagcgctag ttgccaccgc cttaccgcct ttaaagcgaa tgtagatcga
     4201 aaatgtatga ccgaatacgg ccgctaaacc cacgatcagc accagccaat gatgctcgat
     4261 gccaaagaga atgggtaagc tggcagccaa cgtgcctttt aagatatcca gcaccaagac
     4321 aattgagccg ccgactggcc ctaacatgcg ataggcattt gtggtgccaa tattgtgact
     4381 cccgcctttg cggatatccg tgtgataaaa gagtttacca atgaccacac caaacgggat
     4441 ggcgcctatg aaatacgcga gtataaaaca aagcacaagt atcaaatgtg cccctcctct
     4501 caaactagaa actattttag catttttgac ttttgagtga tacgtcagta gaataaaacg
     4561 aacgtacatt cgaataaaac ctgtgaagcg ggttgtggcg cgatttggtg ttgtcttgcg
     4621 caaggatcat ggcggggcac agcgtagata tggtgccagc gggcgatgaa tttcacgtca
     4681 agaagtcata gttatgtgcc atgcttaggg aagtgcggtt ttctgctgag ctttgggaca
     4741 ttgacacggc taataaaatt taaatgaaca atgatggtat tagccagctg ggtcgatttt
     4801 gaggagaaaa caggagtcct gagagcaata cgttgaggtc tgctgttgat ggtgttgatg
     4861 cctaaacgca ctcgcagcaa cctgcgtgta aggaccttgg gtgcaatggt caaagtccaa
     4921 ccatcgcacc caaggccgct tatgctccgg tttctaatcg ggctgctcta ttgaaacgcg
     4981 ctcgcagtcg cagcaacctg cgtgtaaggg acttggccgc aatggtcaaa gccgaccatc
     5041 acgtccaagg ccgcttacac tccggttgct aaccgctcct gctcgcgctc tactgaaacg
     5101 cgctcgccag cccagaaacc tacacataag gaccttgggc acaatcgtca aagcccaacc
     5161 atcgcaccca aggccgccta tgctccggtt tctaatcggg ctggctcgcg ctcttatttt
     5221 ttatttctga aatctcaacg cgtggtgtat tctataactt agttgttcaa aaaagggagt
     5281 ttactatgga taaagcaacg caagcatata atgattcatc cattcaggtg ctgcatggct
     5341 tggaagctgt gcggaagcgt ccggggatgt atattggttc caccgatggc cgcggtttgc
     5401 atcacttggt ctatgaaatc gtggacaact ctgtcgatga agcgctcgcg gggtttgggg
     5461 atgagatcaa tgtgacgatt cacgccgata actctgtgac cgtacaggat catggtcgag
     5521 ggatgccaac ggggatgcac ccgagtggta aaccgacgat tgaagtcatt ttaaccgtgc
     5581 tacatgccgg cggaaaattt aaccaaaata gttacaaaac ttctggtggt ttgcatgggg
     5641 ttggctcaag cgtcgtcaat gccctatcgg agtcattgac tgtgcgagtt gtgcgggata
     5701 aacacgcatt tgaggagcat tttatcaatg gcggtcatcc tgatggcagt ttgcagaagt
     5761 tgggcaaagt taatgaacct aatggcacga ccatcacatt caagccggac ccgactattt
     5821 ttcaaaccac cgtcttcagt tatgatacct tggccgaacg cttgcgcgaa tcagcctttc
     5881 tactgaaaaa tattacgatt aatctgacgg atgaacgcac cggtaagcac gacagttatc
     5941 actatcctga tggcttggtc agttttgtta aataccttaa tgaaggcaaa gacgcattgt
     6001 cacaggtgat caattttgaa ggcaaaaagg acggtatcgt ggttgatttt gccggccaat
     6061 ataacgatgg ctattctgaa aacctgattt cgtttgttaa taacgttcgc actggtgatg
     6121 gcgggacgca tgaaattggc ttgcgcagcg gcatgacgcg agcattcaat gaatttgccc
     6181 gaaaagtcgg cttgctgagg gaacgcgaca agaaccttga aggcagtgat gtgcgtgaag
     6241 gttttgcagg tattttaagt gtccgcattc cagaagaaat tttgcaattt gagggccaga
     6301 caaagggcaa gctaggtacg ccgcaagccc gcactgtggt cgatgggatt gtctatgaca
     6361 agctgtcaac ttttttgatg gaaaacggtg aagagtcgca agagttggtt cgtaaagccg
     6421 tcaaagcccg tgatgcgcgg gaagcggctc gaaaagcgcg cgacgatagc cggacgggac
     6481 gcaagcgcaa gaaggaccaa ggtttgcttt ccggtaaatt gaccccggcg caaaccaaga
     6541 accctaagcg taacgaattg tatctcgtcg aaggggattc tgccggtggt tcagctaaac
     6601 aaggccgaga ccgaaagttt caggcgatct tgccattgcg agggaaagta ctgaataccc
     6661 agaaggccaa gttacaggac atcgttaaaa acgaagaaat caatacgatg atttacacca
     6721 tcggcgctgg tgtcggtgcg gattttgatc tgcagcaggc caactacgac aaaatcatta
     6781 ttatgactga tgcggatact gatggcgcgc atattcagat tttgctacta accttctttt
     6841 atcgctacat gcggccgctg attgacgcag gccgaattta cattgctttg ccaccattgt
     6901 atcggctgca aaaaggcgct ggtgctaaaa ccaagatcag ttatgcttgg accgatgaag
     6961 agttggccaa agagaccaag gccatgggca agggttacac attgacccga tttaaaggac
     7021 ttggggaaat gaatgccgac cagctttggg aaacgactat gaatcctgag acgcggactt
     7081 tgatccgggt tcggattgac gatgctcagc tggcggaacg acgcgtgacc actttgatgg
     7141 gtgatcgcgt tgagccgcgt cgtgaatgga ttgagcataa cgtcaagttt gatatggatg
     7201 acgacggcag tattttggaa accccgactg ctaatcacga aaaattacag tttggtgcca
     7261 agcaaatcgt caaacaactg gacaagaaag gaaagtaaaa gccattggcc aatcagattc
     7321 aagaactgac cttagaagag gtcatgggcg accggtttgg ccggtactcg aaatacatta
     7381 ttcaagaacg ggcgctgcct gatgtgcgtg acggcctcaa accggttcag cgtcgcattt
     7441 tatttgcgat gaaccaagat ggcaatacgt atgataaggg cttccgcaag tcggctaaaa
     7501 gtgtcgggaa tgtcatgggt aattatcatc cccacggcga cagctccatt tatgaagcga
     7561 tggttcggct aagccaggat tggaagttac gggccccact gattcagatg cacgggaata
     7621 acggttccat ggatggtgat ccgccagctg caatgcgata cacggaagcg cgtttaagca
     7681 aaatcagcaa ggaaatgctg gccgacatcg ataaggaaac cgtcgatatg gtgttgaact
     7741 ttgatgacac ggcacaggaa ccgactgtgc tgccagctgg gtttccaaat ttgctggtga
     7801 acggtgccac cggtatttct gccggttatg caaccgaaat tccgccgcac aatctgcggg
     7861 aagttattgc tgccgtctta tacttgctga agcatcccac tgctgattta gatactttaa
     7921 tgcaatacgt caagggtccc gattttccaa caggtgggat tattcaaggg cttgatggca
     7981 tcaagcaagc ttacgaaacc ggccgcggta aaatcgtggt tcgttctcgg acacacatcg
     8041 aaaccattcg tggcggtcgt gagaagatcg tggtcactga gatcccgtat gatgtcaata
     8101 aagcgcagat gattaaaaaa atcgatgaat tacgcatcaa caaaaaagtg gacggtatcg
     8161 ccgaagtccg tgacgaaagc gaccgttttg ggcttagcgt tgtcatcgaa ttaaaaaaag
     8221 aagccgatgc acatggcatc ttaaactatt tatttaaaaa taccgatcta caaattgcat
     8281 acaactttaa catggtcgct attgccgaca tgcagccgaa gttgctagga cttaaggcca
     8341 tgttggaagc atacgtcgaa catcgacgcg atgtggtcac tcggcgaacg cgttttgacc
     8401 tcaacaaggc cgctgctcga cagcacattg tcgaaggctt gatcaaaatg ctatcgattt
     8461 tggatcaggt catcgccgcg attcgtgctt ccaaggataa aggggatgct aagcgtaact
     8521 tagtcaagaa gtttgatttt tcggaagctc aggcggaagc gattgtttcc ttgcagctgt
     8581 atcgattgac caataccgat atcacggctt tacagaaaga agcagcacaa ttggcgaaag
     8641 caatcgccga gtatcaagat attttggccc gccccgctgc ccgcgatcgg gtgattgaag
     8701 gcgagttgaa gcggattgcc aaggagtacg gggatgatcg tcgcagcagc attcaagcca
     8761 aaattgaaac acttgaagtg gcgacaacgg tgacggtggc tgatgaaacc gtcatggtgc
     8821 aggtttctcg tgatgggtac gttaaacgca gttcactgcg cagttatcag gcggttgatc
     8881 cggccgacaa tggtttgaag gccaatgatc ttgccatttt cactggcgaa ctgagtacgt
     8941 tgcagcatct ttacatcgtg acaaatgccg gaaatgtcat ttatcgacca gtgcatgaaa
     9001 ttagtgatgc gcgttggaaa gacaccggcg aacacttaag ccaaacagtt ggccttggca
     9061 ctgacgaaaa agtcttggca gtgtttgctt ttgatcaact cgatggcgct ggcagttttg
     9121 tgttagggtc aagtgacggg tacatcaaac aaactgcctt aagtgatttg cagccgcaac
     9181 ggacgtacaa gagtaagccg atgatggcga tgaagctgaa agacccagcc gcgattgtca
     9241 ccaatgcata cttcacgact gatcagcaac aggatgtctt tgtggtcagc cgccacgctt
     9301 acggactgac attcccgtta agcgatgtgt caactgtcgg tgcccgggca accggcgtta
     9361 aaagtatgga tctaaagcca gacgatgagg ttgtcaattt cattctagtg aaggatccaa
     9421 ctacggctaa ggtcggtatt ttgacccaac gtggcgcctt caaaaagatg gccttaagcg
     9481 aagtcgggga aatgagtcgt gcccgtcgtg gtttactggt cttgcgtgag cttaagcgtg
     9541 atccgcatcg gattgtcgcg atgatgtcag tcgatgacgc tacccgcctg aatgttttga
     9601 ccgatacggg taaggtaacg acccttaatc cggcacaaca tccagcaggt gaccgctatt
     9661 cgaatggttc gtttgtcatt gacactgatg tccttggcaa gccagttttt gttcaaacca
     9721 aagaagaacc agcagatcaa gtcgaataaa tggtgatcat tgacaccgcc gtctgtacta
     9781 atacagatgg tggcgttttt gattattata ggacagacca gttgtgcaca atttaacaaa
     9841 atgccgaaat catgggcgaa aagaagcgac gaagcacact taaaaaacaa tataacgcct
     9901 attatatggg caataaaacg cttgcataga tttggcggcg tgttatactg tgtttgtaag
     9961 aactgtcaca tctgtaatcc actttaggag gcaaacaact atgaaacagc ttgacgaaac
    10021 caaagttcct aattattggg aaggctttaa cggcggcgac tggcaagaag aaattaatgt
    10081 gcgcgatttt atcgagcata acctgaacca atatgacggg gacgaaagtt tccttgctgg
    10141 ccccactgaa gcgacaacag tcctgaacaa tcaggttcta aatttaaaga agcaagaacg
    10201 tgcaaatggc ggtgttttgg atgctgacaa caatattcca tctacgatca cctcacatgg
    10261 ccctggttat ttgaacaaag atcttgaaaa gattgttggt gttcagaccg acaagccatt
    10321 caaacgagca ttcatgccat ttggcggtat tcgaatggct gaagatgcat tggaatctta
    10381 tggcttcaag acagatcctc aagaacacaa gattttcaat gaatatcgta agacccataa
    10441 ccaaggtgtc tttgatgctt atacccctga tatgcgaaag gctcgccatt acaagatcgt
    10501 gactggcttg ccagacgcat acggccgcgg ccggattgtt tctgatttcc cacggatcgc
    10561 tgtttacggg atcgatcgtt taatggctga gaagttcaag gattataact tgaccggcga
    10621 cggcgaaatg actgacgatg taatcaaatt gcgtgaagaa atcaatgaac aatatcgtgc
    10681 cttaaacgac atgaagaaga tggccaagga atatggctat gacatctcgc gtccggcagc
    10741 taatgcgcaa gaagctgttc agtggatcta ctttggctat ctggctgctg ttaagactca
    10801 aaacggtgcc gcaatgtccg ttggccggat cgatacggtt attgatgctt atatccaacg
    10861 cgatatgcgc ttaggcaaat tgaacgaaga acaggcacag gaactgattg atcatttggt
    10921 tatgaaattg cggatggttc gtttcatccg gactgaagaa tataactcac tgttctcagg
    10981 cgatccaatc tgggcaacct tgtcattggc aggaatgggc aatgatggcc gtcaccacgt
    11041 taccaagacg gctttccgtt tcctgaagac tttggacaac atgggcgcag caccagaacc
    11101 aaacatcacc ttgctttgga gcgaacgctt gccagaaggc tttaaacgct atgcaaccga
    11161 agtatccatc caaagttcaa ccattcaata tgaaaatgat gacctgatgc gcaacgaatg
    11221 gggtaccgat tactacggta ttgcttgctg tgtctcggca caaccaattg ctgatggcgt
    11281 tcaatacttt ggtgcccgtg ctaacttagc taagacagtt ctgtatgcga tcaacggtgg
    11341 gaaagatgaa attcaggaag cgcaagtagg gcctgaatat gcaccgatca ccagcgatta
    11401 cattgattac aaagaattca tgaataagtt cgacaagatg atggactggc tggccgacac
    11461 gtatgtcaat gctttgaatg tgattcacta tatgcatgac aagtattatt atgaagctgc
    11521 acagctggca ttgaaggata cccaactgaa ccggaccttc gcaaccggga tttccggcct
    11581 gtcacacgcg gttgattcca tcagtgcaat caagtatggt catgtcaagg caattcgcga
    11641 tgaaaacggt gttgcagttg acttcgttgc tgacaatgat gactatccac gttatggtaa
    11701 caacgatgat cgcgctgatg acatcgctaa gtggttggtt aagaccttct ataacaagat
    11761 gaacacgcat catctgtatc gcggcgcgaa gttgagcacc agtgtcctga ccattacttc
    11821 caacgtggtt tatggtaaga atacagggac aacaccaaac ggtcgtcaaa aaggcgaacc
    11881 attctcacca ggtgccaacc cggcatatgg cgcagaaaag aacggcgcac tggcatccct
    11941 gatgtccacc gccaagattc cgtatcatta cgcaactgac ggcattagta atacgtttgg
    12001 ggttactccg aacacactgg gccacgatga tgaaactcgt aaggatacct tggttcacat
    12061 ggttgacggc tatatggaaa acagcggcat gcatttgaac atcaacgtct tcaacaagga
    12121 gaccttgatt gatgctcaga agcacccaga agaataccca acattgaccg ttcgggtttc
    12181 tggctactgc gtctacttcg cagatttgac caaggaacaa caagacgatg tcattgctcg
    12241 gaccttcttc gaagaaatgt aagcagctta actcaagaca ggaagccatt cctgttttgc
    12301 caaaagacgg caacgatgct gttgccgttt tttggcagaa tgaaatgaaa atcaattgaa
    12361 aacgacacat gatgttgtag tggaggcaat aagatgaaac tcatcgatca gtcacaaagc
    12421 ccattaaata tcttagaaca agttggtcag gatcatgatg gcccgatcaa agggtatgtt
    12481 cactcggtcg aaagttttgg ttcggtcgat ggccctggta ttcgcttcgt tgtctttatg
    12541 caagggtgtc gcatgcgttg ccagtattgt cacaaccctg acacctggaa cattggggtt
    12601 ggtgaagaaa tgacggccga tcaaattttg gcggatgccc agcgctataa agcattctgg
    12661 ggtgaccaag ggggtattac ctgcagtggc ggtgagagtt tggtacaaat cgatttcatt
    12721 ctcgaactct tcaccaaggc taaggcactg ggaatttcga cttgcctcga tacgtcaggc
    12781 ggccccttca cgcgtgacca accgtggttt ggccagtttg aaaagctgat ggctgttact
    12841 gacatctcat tagttgatat taaacacatt gattcggccg agcataaaaa gctcaccggt
    12901 tttcctaatg agaatatttt ggatatggtg cagtatatgt cggcgcatgg tgatgacatg
    12961 tggattcgcc acgttctggt cccggaacgc actgactttg acccttatct caaacggtta
    13021 ggggactata ttgcgacatt ggacaaaaac gtggtccaaa aagttgagat tcttccgtat
    13081 cacacgttag gcgttaaaaa gtatcacgag cttggcatta cgtacccgct tgaaggcatc
    13141 gaaccgccgt ctgccgatcg cgttaagaat gcagagaatc tgctgcacgt taaggattat
    13201 accggatggc aaagctggcg tccgaaacca gttgcgagca actgaatctt tagctagaac
    13261 ttaacgtaac gattaaaaac gcggcaaatt cgttgcgttt tttttcattg ccacttatga
    13321 tgatggttga acgatattat taaattataa acgaaaggga agccgcccta tgaaaacgaa
    13381 acaagagcgc attttttcct caaagacact aacttatttt ctgcaattgg cagaaaccat
    13441 gaactacacc caagccgccc aattgcttgg cattacccag ccagccttaa cacagcagat
    13501 caagaaattg gaacggacgg tgggggcacc gctgttttat tctgtcggga agaaactgca
    13561 tttatctgac gctggtcaga ccatgttaaa gtcaacccat gagatctacg agatcttgaa
    13621 ccagacaacc gacgaaattc aacaaacaac cagtgcaacc gtcggaaaaa tcaatattgg
    13681 gttattaagc tcaattgagg atagcgcctt tattgcgttc attgctcatt actatcaact
    13741 gaatcctgaa gttgaagtaa cgctacggat gatgacccgt cacgaaattt gggaatcctt
    13801 ggaaaacaac cagattgatt tggctatcat gaatctgcca gatgagacca ttaagaactg
    13861 gaaaccatac gccagcaaga aaattattga tgaacaattg ctgttcttgc accacgatga
    13921 cgccttggct aaccgtaagc gaatccattt caaagatact ttagctgaac cttggtcaac
    13981 ttatcctgac gactatttcc ttggacagct tctgcgtgag gcgtacaaga atcaaatggt
    14041 tgatttcccg cacgtggtcg cacatttcac cacgccatat cagttaaccc aattcgttaa
    14101 cttgtcaggg gtcaacacgg ccttaccaac cagttttgtt cgggcacgcg ctgatcaaat
    14161 caaggcctat gctattgcgt ttgatccggc cattcgcttt gagatttctt ttgtttatcg
    14221 caaagagaaa gctgacattc cgcggatctc gaacttcttc cagacctttg acgattatct
    14281 gaaggaaaaa gattacttgt cgcgggtcag tgaaaaccgt gttaaacttg ataagtaaac
    14341 tattcagttg aggagcgatc agataagatg acgactttga tttttgggca tcagaacccg
    14401 gacaccgacg cgattacgag tgccatgagc tgggcagaat ttcagaaaca ggcaggcaac
    14461 acggatgttg aggcggtagc attaggcgga ccgaacgatg aaactaagtt cgtccttgat
    14521 cactttaagg ttcaggcacc gcgggttatc aagacggcag ccaacgagac ggatcatgtc
    14581 atgttggttg atcacaacga atttcaacaa agtgtcagtg atatcgaaga cgtgacgatt
    14641 gattctgttg tcgaccatca tcgcatcgct aacttccaca cggcagcgcc gctgttttac
    14701 cgagcagaac cggttggcag caccaatacc gtcatttttg agatgttcca agaatatggc
    14761 ttcaagattt cgccaacatt ggctggtttg atggcttctg gtttgatttc agacacgctg
    14821 ttgttgaaat cgccgaccgc aaccgataag gataagaaga ttttgccaga aatggcgaag
    14881 attgccggaa ttgatttgca gtcatatggt cttgccatgc tgaaggcagg tactaatttg
    14941 gccgccaagt cagatatgga cattatcgaa ggcgatgcta agagtttcac catgggcggc
    15001 aagtctattc gcatcggaca ggtcaatacc gttgatctga acgacattta cgcacgtcag
    15061 gacgaattga tcagtgccat gaccaaagag gcgcaggcga aaggctacga cgatttcctg
    15121 ctgattgcca ctgacatctt ggacagcaat tcaactggtt tcgcagtcgg tgctgaccgc
    15181 gataaaatcg ccagtgcttt caacgaacag ttcgacaagg acgcgcgttt ggcattgcct
    15241 ggggttgttt cccgcaaaaa acaggtcgtt ccgccaatgc agagcacgtt tgaaggttaa
    15301 ctttcatctt taattgcaca caattgttct aaggaaagtc gcagctagcc agttgcggct
    15361 tttttgtggc tctacgtcaa ctggtgttga agaataaatt tatcatttga ggcggttctc
    15421 c
//
