LOCUS       c00038_gnlPro..        15420 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|CEDBCKDO_38.
ACCESSION   c00038_gnlPro..
VERSION     c00038_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2025-04-30 22:09:46
            Original ID  :: gnl|Prokka|CEDBCKDO_38
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15420
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15420
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2175:5420]"
                     /cutoff="2000"
                     /detection_rule="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /neighbourhood="10000"
                     /product="Pyruvate2acetate-formate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      2176..5420
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="2000"
                     /detection_rule="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /neighbourhood="10000"
                     /product="Pyruvate2acetate-formate"
                     /protocluster_number="1"
     cand_cluster    1..15420
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /kind="single"
                     /product="Pyruvate2acetate-formate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15420
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Pyruvate2acetate-formate"
                     /region_number="1"
                     /rules="((PFL_acetate1 or PFL_acetate2) and Radical_SAM)"
                     /tool="gutsmash"
     CDS             complement(121..1053)
                     /locus_tag="ctg38_1"
                     /transl_table=11
                     /translation="MTTLIFGHQNPDTDAITSAMSWAEFQKQAGNTGVEAVALGEPNDE
                     TKFVLDHFKVQAPRVIKTAANETDHVMLVDHNEFQQSVSDIEDVTIDSVVDHHRIANFH
                     TAAPLFYRAEPVGSTNTVIFEMFQEYGFKISPTLAGLMASGLISDTLLLKSPTATDKDK
                     KILPEMAKIARIDLQSYGLAMLKAGTNLAAKSDMDIIEGDAKSFTMGGKSIRIGQVNTV
                     DLNDIYARQDELISAMTKEAQAKGYDDFLLIATDILDSNSTGFAVGADRDKIASAFNEQ
                     FDKDARLALPGVVSRKKQVVPPMQSTFEG"
     CDS             complement(1083..2051)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LysR_substrate"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HTH_1"
                     /gene_functions="regulatory (smcogs) SMCOG1012:Bacterial
                     regulatory helix-turn-helix protein, lysR family (Score:
                     60.8; E-value: 3.2e-19)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg38_2"
                     /sec_met_domain="LysR_substrate (E-value: 8.8e-27,
                     bitscore: 85.7, seeds: 361, tool: rule-based-clusters)"
                     /sec_met_domain="HTH_1 (E-value: 3e-19, bitscore: 60.8,
                     seeds: 1330, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTKQERIFSSKTLTYFLQLAETMNYTQAAQLLGITQPALTQQIK
                     KLERTVGAPLFYSVGKKLHLSDAGQTMLKSTHEIYEILNQTTDEIQQTTSATVGKINIG
                     LLSSIEDSAFIAFIAHYYQLNPEVEVTLRMMTRHEIWESLENNQIDLAIMNLPDETIKN
                     WKPYASKKIIDEQLLFLHHDDALANRKRIHFKDTLAEPWATYPDDYFLGQLLREAYKNQ
                     MVDFPHVVAHFTTPYQLTQFVNLSGVNTALPTSFVRARADQIKAYAIAFDPAIRFEISF
                     VYRKEKADIPRISNFFQTFDDYLKEKDYLSRVSENRVKLDK"
     CDS             complement(2176..3027)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Pyruvate2acetate-formate: Radical_SAM"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1015:4Fe-4S single cluster domain (Score: 65.2;
                     E-value: 2.4e-20)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg38_3"
                     /sec_met_domain="Radical_SAM (E-value: 1.5e-25, bitscore:
                     82.4, seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLIDQSQSPLNILEQVGQDHDGPIKGYVHSVESFGSVDGPGIRF
                     VVFMQGCRMRCQYCHNPDTWNIGVGEEMTADQILADAQRYKAFWGDQGGITCSGGESLV
                     QIDFILELFTKAKALGISTCLDTSGGPFTRDQPWFGQFEKLMAVTDISLVDIKHIDSAE
                     HKKLTGFPNENILDMVQYMSAHGDDMWIRHVLVPERTDFDPYLKRLGDYIATLDKNVVQ
                     KVEILPYHTLGVKKYHELGITYPLEGIEPPSADRVKNAENLLHVKDYTGWQSWRPKPVA
                     SN"
     CDS             complement(3159..5420)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Pyruvate2acetate-formate: PFL_acetate2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Gly_radical"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg38_4"
                     /sec_met_domain="Gly_radical (E-value: 2.3e-41, bitscore:
                     132.6, seeds: 99, tool: rule-based-clusters)"
                     /sec_met_domain="PFL_acetate2 (E-value: 1.5e-243, bitscore:
                     801.5, seeds: 33, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKQLDETKVPNYWEGFNGGDWQEEINVRDFIEHNLNQYDGDESFL
                     AGPTEATTVLNNQVLNLKKQERANGGVLDADNNIPSTITSHGPGYLNKDLEKIVGVQTD
                     KPFKRAFMPFGGIRMAEDALESYGFKTDPQEHKIFNEYRKTHNQGVFDAYTPDMRKARH
                     YKIVTGLPDAYGRGRIVSDFPRIAVYGIDRLMAEKFKDYNLTGDGEMTDDVIKLREEIN
                     EQYRALNDMKKMAKEYGYDISRPAANAQEAVQWIYFGYLAAVKTQNGAAMSVGRIDTVI
                     DAYIQRDMRLGKLNEEQAQELIDHLVMKLRMVRFIRTEEYNSLFSGDPIWATLSLAGMG
                     NDGRHHVTKTAFRFLKTLDNMGAAPEPNITLLWSERLPEGFKRYATEVSIQSSTIQYEN
                     DDLMRNEWGTDYYGIACCVSAQPIADGVQYFGARANLAKTVLYAINGGKDEIQEAQVGP
                     EYAPITSDYIDYKEFMNKFDKMIDWLADTYVNALNVIHYMHDKYYYEAAQLALKDTQLN
                     RTFATGISGLSHAVDSISAIKYGHVKAIRDENGVAVDFVADNDDYPRYGNNDDRADDIA
                     KWLVKTFYNKMNTHHLYRGAKLSTSVLTITSNVVYGKNTGTTPNGRQKGEPFSPGANPA
                     YGAEKNGALASLMSTAKIPYHYATDGISNTFGVTPNTLGHDDETRKDTLVHMVDGYMEN
                     SGMHLNINVFNKETLIDAQKHPEEYPTLTVRVSGYCVYFADLTKEQQDDVIARTFFEEM
                     "
     CDS             complement(5672..8116)
                     /locus_tag="ctg38_5"
                     /transl_table=11
                     /translation="LANQIQELTLEEVMGDRFGRYSKYIIQERALPDVRDGLKPVQRRI
                     LFAMNQDGNTYDKGFRKSAKSVGNVMGNYHPHGDSSIYEAMVRLSQDWKLRAPLIQMHG
                     NNGSMDGDPPAAMRYTEARLSKISKEMLADIDKETVDMVLNFDDTAQEPTVLPAGFPNL
                     LVNGATGISAGYATEIPPHNLREVINAVLYLLKHPTADLDTLMQYVKGPDFPTGGIIQG
                     LDGIKQAYETGRGKIVVRSRTHIETIRGGREKIVVTEIPYDVNKALMIKKIDELRINKK
                     VDGIAEVRDESDRFGLSVVIELKKEADAHGILNYLFKNTDLQIAYNFNMVAIADMQPKL
                     LGLKAMLEAYVEHRRDVVTRRTRFDLNKAAARQHIVEGLIKMLSILDQVIAAIRASKDK
                     GDAKRNLVKKFDFSEAQAEAIVSLQLYRLTNTDITALQKEAAQLAKAIAEYQDILARPA
                     ARDRVIEGELKRIAKEYGDDRRSSIQAKIETLEVATTVTVADETVMVQVSRDGYVKRSS
                     LRSYQAVDPADNGLKANDLAIFTGELSTLQHLYIVTNAGNVIYRPVHEISDARWKDTGE
                     HLSQTVGLGTDEKVLAVFAFDQLDGAGSFVLGSSDGYIKQTALSDLQPQRTYKSKPMMA
                     MKLKDPAAIVTNAYFTTDQQQDVFVVSRHAYGLTFPLSDVSTVGARATGVKSMDLKPDD
                     EVVNFILVKDPTTAKVGILTQRGAFKKMALSEVGEMSRARRGLLVLRELKRDPHRIVAM
                     MSVDDATRLNVLTDTGKVTTLNPAQHPAGDRYSNGSFVIDTDVLGKPVFVQTKEEPADQ
                     VE"
     CDS             complement(8123..10135)
                     /locus_tag="ctg38_6"
                     /transl_table=11
                     /translation="MDKATQAYNDSSIQVLHGLEAVRKRPGMYIGSTDGRGLHHLVYEI
                     VDNSVDEALAGFGDEINVTIHADNSVTVQDHGRGMPTGMHPSGKPTIEVILTVLHAGGK
                     FNQNSYKTSGGLHGVGSSVVNALSESLTVRVVRDKRAFEEHFINGGHPDGTLQKLGKVN
                     EPNGTTITFKPDPTIFQTTVFSYDTLAERLRESAFLLKNITINLTDERTGKHDSYHYPD
                     GLVSFVKYLNEGKDALSQVINFEGKKDGIVVDFAGQYNDGYSENLISFVNNVRTGDGGT
                     HEIGLRSGMTRAFNEFARKVGLLKERDKNLEGSDVREGLAGILSVRIPEEILQFEGQTK
                     GKLGTPQARTVVDGIVYDKLSTFLMENGEESQELVRKAVKARDAREAARKARDDSRTGR
                     KRKKDQGLLSGKLTPAQTKNPKRNELYLVEGDSAGGSAKQGRDRKFQAILPLRGKVLNT
                     QKAKLQDIVKNEEINTMIYTIGAGVGADFDLQQANYDKIIIMTDADTDGAHIQILLLTF
                     FYRYMRPLIDAGRIYIALPPLYRLQKGAGAKTKISYAWTDEELAKETKAMGKGYTLTRF
                     KGLGEMNADQLWETTMNPETRTLIRVRIDDAQLAERRVTTLMGDRVEPRREWIEHNVKF
                     DMDDDGSILETPTANHEKLQFGAKQIVKQLDKKGK"
     CDS             10543..11250
                     /locus_tag="ctg38_7"
                     /transl_table=11
                     /translation="MYVRFILLTYHSKVKNAKIVSSLRGGAHLILVLCFILAYFIGAIP
                     FGVVIGKLFYHTDIRKGGSHNIGTTNAYRMLGPVGGSIVLVLDILKGTLAASLPILFGI
                     EHHWLVLIVGLAAVFGHTFSIYIRFKGGKAVATSAGILLAYNPPFFVIAFAIWFSLILL
                     TSMVSVASTLGMVLITVWSLVYHDWLLTTVACGLLVVFLIKHRANFKRIKAGDENMVPF
                     GLGQYLRQHRGRS"
     CDS             complement(11332..12210)
                     /locus_tag="ctg38_8"
                     /transl_table=11
                     /translation="MVTIANDFLTVKISRHGAELTSIKDNLTGRERLWQADPAVWGRHA
                     PVLFPIVGALADNQYHYAGKTYHMGQHGFARDRDFTVLSATPFKASFVLKDDDKTRAMY
                     PFAFRLIITFALENNNLHVTYHVDNPDKSEPLFFSIGGHPGFKVPMTPDTKFSDYYLNF
                     KPRKSLVQIPLVAGEGIDYTHRTLAATDANLALTHETFDHDALIFALLGKTTFNLVSDK
                     TKHGVSVTMTDTPYLGVWSPYPTTGDFVCIEPWWGIADTIGSTGDLTRKLGINRLEPGT
                     AFQKGYMISIF"
     CDS             complement(12246..13655)
                     /locus_tag="ctg38_9"
                     /transl_table=11
                     /translation="MAEVQTPKQIVEKLDQYVIGQDDAKRAVAVALYNRYRRMQLSPKM
                     QEEITPKNLLMIGPTGVGKTEIARRLAKIVEAPFVKVEATKFTEVGYVGRDVESMVRDL
                     AETAVAMEEEKQFSKVRIRAEKEANKRLVKILVPAIRKEKNTNPMAEMMSMLQGMQNGK
                     MPAGDDADAGGEVTDDIRNKRLSVAEQLEKGLLEDHEITVAVNDEKKGGGMGDMYGQMG
                     IDLSDTIGALMPKKKVERTMTVKEAREIFIKEESDKLVNHADIYHDAIQSAENNGIIFI
                     DEIDKIAAGNKHNSGEVSREGVQRDILPIVEGSQINTKYGPINTDHILFIGSGAFAEAK
                     PSDLIAELQGRFPIRVELKDLTEKDFVRILTEPDNALIKQYIALIGADGVKITFTKEAV
                     DRIAEIATQVNHDTDNIGARRLATILEKLLEDVLYEGPDMAMGAVTVTQQYVDDKIGHI
                     AADSNMTRYIL"
     CDS             complement(13699..14277)
                     /locus_tag="ctg38_10"
                     /transl_table=11
                     /translation="MLRFLSDSARAHLKGSMTMTTIAAVRKDGVTALAGDGQVTLGEKV
                     IMKGNAQKVRRIYHDQVVIGFAGGVADAFTLQDWFEKKLEHYAGNLRRSAVALAQDWRK
                     DPTLQKLEAMMIVMDEHDLLLVSGSGEVIDPDEDVVAIGSGGNFAQAAAIAMLRHAPDM
                     TPADIAKEAVNIAGNIDIFTNHNVIVESF"
     CDS             complement(14471..15367)
                     /locus_tag="ctg38_11"
                     /transl_table=11
                     /translation="MKPIAAFQEYLEVERQYSPETVTAYLSDLQEFQAFLKANGGFTDF
                     RHVDDLDVQTYLTDLNKQDLARTSIARKISSLRSFYRYLTRIDVVKRNPFELVELKKQH
                     HHLPQFFYEAEIQELFKTVAGKTPLDQRNRALLEVLYGTGIRVSECAKLTLNQVDFNTA
                     LLLIHGKGNKDRYVPFGQYAQQALRTYLKDGRQVLMAKSQAQHRYVFVNQYGHPITSRG
                     IEYILDQLIKQTTLTANIHPHMLRHSFATHMLDHGADLRTVQELLGHASLSTTQIYTHV
                     TMAHLKNEYMKYYPKHN"
ORIGIN
        1 gagaaccgcc tcaaatgata aatttattct tcaacaccag ttggcgtaga gccacaaaaa
       61 agccgcaact ggctagctgc gacttttctt agaacaattg tgcacaatta aagatgaaag
      121 ttaaccttca aacgtgctct gcattggcgg aacaacctgc tttttgcggg aaacgacgcc
      181 tggcaatgcc aaacgcgcgt ccttgtcgaa ctgctcgttg aaagcactgg cgattttatc
      241 gcggtcagca ccgactgcga aaccagttga attgctgtcc aagatgtcag tggcaatcag
      301 caggaaatcg tcgtagcctt tcgcctgcgc ctctttggtc atggcactga tcaattcgtc
      361 ctgacgtgcg taaatgtcgt tcagatcgac ggtattgacc tgtccgatgc gaatagactt
      421 gccgcccatg gtgaaactct tagcatcgcc ttcgataatg tccatatctg acttggcggc
      481 caaattagtg cctgccttca gcatggcaag accatatgac tgcaaatcaa ttctggcaat
      541 cttcgccatt tctggcaaaa tcttcttatc cttgtcggtt gcggtcggcg acttcaacaa
      601 cagcgtgtct gaaatcaaac cagaagccat caaaccagcc aatgttggcg aaatcttgaa
      661 gccatattct tggaacatct caaaaatgac ggtattggtg ctgccaaccg gttctgctcg
      721 gtaaaacagc ggcgctgccg tgtggaagtt agcgatgcga tgatggtcga caacagaatc
      781 aatcgtcacg tcttcgatat cactgacact ttgttgaaat tcgttgtgat caaccaacat
      841 gacatgatcc gtctcgttgg ctgccgtctt gataacccgc ggtgcctgaa ccttgaagtg
      901 atcaaggacg aacttagtct catcgttcgg ttcgcctaat gctaccgctt caacacccgt
      961 gttgcccgcc tgtttctgaa attctgccca gctcatggca ctcgtaatcg cgtcggtgtc
     1021 cgggttctga tgcccaaaaa tcaaagtcgt catcttatct gatcgctcct caactgaata
     1081 gtttacttat caagtttaac acggttttca ctgacccgcg acaagtaatc tttttccttc
     1141 agataatcgt caaaggtctg gaagaagttc gagatccgcg gaatgtcagc tttctctttg
     1201 cgataaacaa aagaaatctc aaagcgaatg gccggatcaa acgcaatagc ataggccttg
     1261 atttgatcag cgcgtgcccg aacaaaactg gttggtaagg ccgtgttgac ccctgacaag
     1321 ttaacgaatt gggttaactg atacggcgtg gtgaaatgtg cgaccacgtg cgggaaatca
     1381 accatttgat tcttgtacgc ctcacgcaga agctgtccaa ggaaatagtc gtcaggataa
     1441 gttgcccaag gttcagctaa agtatctttg aaatggattc gcttacggtt agccaaggcg
     1501 tcatcgtggt gcaagaacag caattgttca tcaataattt tcttgctagc gtatggtttc
     1561 cagttcttaa tggtctcatc tggcagattc atgatagcca aatcaatctg gttgttttcc
     1621 aatgattccc aaatttcgtg acgggtcatc atccgtagcg ttacttcaac ttcaggattc
     1681 agttgatagt aatgagcaat gaacgcaata aaagcgctat cctcgatcga gcttaataac
     1741 ccaatattga tttttccgac ggttgcactg gttgtttgtt gaatttcgtc ggttgtctgg
     1801 ttcaagatct cgtatatctc atgggttgac tttaacatgg tctgaccagc gtcagataaa
     1861 tgcagtttct tcccgacaga ataaaacagc ggtgccccca ctgtccgttc caatttcttg
     1921 atctgctgtg ttaaggctgg ctgggtaatg ccaagcaatt gggcggcttg ggtgtagttc
     1981 atggtttctg ccaattgcag aaaataagtt agtgtctttg aggaaaaaat gcgctcttgt
     2041 ttcgttttca tagggcggct tccctttcgt ttataattta ataatatcgt tcaaccatca
     2101 tcataagtgg caatgaaaaa aaacgcaacg aatttgccgc gtttttaatc gttacgttaa
     2161 gttctagcta aaaattcagt tgctcgcaac tggtttcgga cgccagcttt gccatccggt
     2221 ataatcctta acgtgcagca gattctctgc attcttaacg cgatcggcag acggcggttc
     2281 gatgccttca agcgggtacg taatgccaag ctcgtgatac tttttaacgc ctaacgtgtg
     2341 atacggcaga atctcaactt tttggaccac gtttttgtcc aatgtcgcaa tatagtcccc
     2401 taaccgtttg agataagggt caaagtcagt gcgttccggg accagaacgt ggcgaatcca
     2461 catgtcatca ccatgcgccg acatatactg caccatatcc aaaatatttt cattaggaaa
     2521 accggtgagc tttttatgct cggccgaatc aatgtgttta atatcaacta atgagatgtc
     2581 agtaacagcc atcagctttt caaactggcc aaaccacggt tggtcacgcg tgaaggggcc
     2641 gcctgacgta tcgaggcaag tcgaaattcc cagtgcctta gccttggtga agagttcgag
     2701 aatgaaatcg atttgtacca aactctcacc gccactgcag gtaataccac cttggtcacc
     2761 ccagaatgct ttatagcgct gggcatccgc caaaatttga tcggccgtca tttcttcacc
     2821 aaccccaatg ttccaggtgt cagggttgtg acaatactgg caacgcatgc gacacccttg
     2881 cataaagaca acgaagcgaa taccagggcc atcgaccgaa ccaaaacttt cgaccgagtg
     2941 aacataccct ttgatcgggc catcatgatc ctgaccaact tgttctaaga tatttaatgg
     3001 gctttgtgac tgatcgatga gtttcatctt attgcctcca ctacaacatc atgtgtcgtt
     3061 ttcaattgat tttcatttca ttctgccaaa aaacggcaac agcatcgttg ccgtcttttg
     3121 gcaaaacagg aatggcttcc tgttttgagt taagctgctt acatttcttc gaagaaggtc
     3181 cgagcaatga catcgtcttg ttgttccttg gtcaaatctg cgaagtagac gcagtagcca
     3241 gaaacccgaa cggtcaatgt tgggtattct tctgggtgct tctgagcatc aatcagggtc
     3301 tccttgttga agacgttgat gttcaaatgc atgccgctgt tttccatata gccgtcaacc
     3361 atgtgaacca aggtatcctt acgagtttca tcatcgtggc ccagtgtgtt cggagtaacc
     3421 ccaaacgtat tactaatgcc gtcagttgcg taatgatacg gaatcttggc ggtggacatc
     3481 aaggatgcca atgcgccgtt cttttctgcg ccgtatgccg ggttggcacc tggtgagaat
     3541 ggttcgcctt tttgacgacc gtttggtgtt gtccctgtat tcttaccata aaccacgttg
     3601 gaggtaatgg tcagaacact ggtactcaac ttcgcgccgc gatacagatg atgcgtgttc
     3661 atcttgttat agaaggtctt aaccaaccac ttagcgatgt catcagcgcg atcatcgttg
     3721 ttaccatagc gtggatagtc atcattgtca gcaacgaagt caactgcaac accgttttca
     3781 tcgcgaattg ccttgacatg accatacttg attgcactga tggaatcaac tgcgtgtgac
     3841 aggccggaaa tcccggttgc gaaggtccgg ttcagttggg tatccttcaa tgccagctgt
     3901 gcagcttcat aataatactt gtcatgcata tagtgaatca cattcaaagc attgacatac
     3961 gtgtcggcca gccagtctat catcttgtcg aacttattca tgaattcttt gtaatcaatg
     4021 taatcgctgg tgatcggtgc atattcaggc cctacttgcg cttcctgaat ttcatctttc
     4081 ccaccgttga tcgcatacag aaccgtctta gctaagttag cacgggcacc aaagtattga
     4141 acgccatcag caattggttg tgccgagaca cagcaagcaa taccgtagta atcggtaccc
     4201 cattcgttgc gcatcaggtc atcattttca tattgaatgg ttgaactttg gatggatact
     4261 tcggttgcat agcgtttgaa gccttctggc aagcgttcgc tccaaagcaa ggtgatgttt
     4321 ggttctggtg ctgcgcccat gttgtccaaa gtcttcagga aacggaaagc cgtcttggta
     4381 acgtggtgac ggccatcatt gcccattcct gccaatgaca aggttgccca gattggatcg
     4441 cctgagaaca gtgagttata ttcttcagtc cggatgaaac gaaccatccg caatttcata
     4501 accaaatgat caatcagttc ctgtgcctgt tcttcgttca atttgcctaa gcgcatatcg
     4561 cgttggatat aagcatcaat aaccgtatcg atccggccaa cggacattgc ggcaccgttt
     4621 tgagtcttaa cagcagccag atagccaaag tagatccact gaacagcttc ttgcgcatta
     4681 gctgccggac gcgagatgtc atagccatat tccttggcca tcttcttcat gtcgtttaag
     4741 gcacgatatt gttcattgat ttcttcacgc agtttgatta catcgtcagt catttcgccg
     4801 tcgccggtca agttataatc cttgaacttc tcagccatta aacgatcgat cccgtaaaca
     4861 gcgatccgtg ggaaatcaga aacaatccgg ccacggccgt atgcgtctgg caagccagtc
     4921 acgatcttgt aatggcgagc ctttcgcata tcaggggtat aagcatcaaa gacaccttgg
     4981 ttatgggtct tacgatattc attgaaaatc ttgtgttctt gaggatctgt cttgaagcca
     5041 taagattcca atgcatcttc agccattcga ataccgccaa atggcatgaa tgctcgtttg
     5101 aatggcttgt cggtctgaac accaacaatc ttttcaagat ctttgttcaa ataaccaggg
     5161 ccgtgtgagg tgatcgtaga tggaatattg ttgtcagcat ccaaaacacc gccatttgca
     5221 cgttcttgct tctttaaatt tagaacctga ttgttcagga ctgttgtcgc ttcagtgggg
     5281 ccagcaagga aactttcgtc cccgtcatat tggttcaggt tatgctcgat aaaatcgcgc
     5341 acattaattt cttcttgcca gtcgccgccg ttaaagcctt cccaataatt aggaactttg
     5401 gtttcgtcaa gctgtttcat agttgtttgc ctcctaaagt ggattacaga tgtgacagtt
     5461 cttacaaaca cagtataaca cgccgccaaa tctatgcaag cgttttattg cccatataat
     5521 aggcgttata ttgtttttta agtgtgcttc gtcgcttctt ttcgcccatg atttcgtcat
     5581 tttattaaat tgtgcacaac tgatctgtcc tataataatc aaaaacgcca ccatctgtat
     5641 tggtacagat ggtggcgtca atgatcacca tttattcgac ttgatctgct ggttcttctt
     5701 tggtttgaac aaaaactggc ttgccaagga catcagtgtc aatgacaaac gaaccattcg
     5761 aatatcggtc acctgctgga tgttgtgccg gattaagggt cgttacctta cccgtatcgg
     5821 tcaaaacatt caggcgggta gcgtcatcga ctgacatcat cgcgacaatc cgatgcggat
     5881 cacgcttaag ctcacgcaag accagtaaac cacgacgggc acgactcatt tccccgacct
     5941 cgcttaaggc catctttttg aaggcgccac gttgggtcaa aataccgacc ttagccgtag
     6001 ttggatcctt cactagaatg aaattgacaa cctcatcgtc tggctttaga tccatacttt
     6061 taacgccggt tgcccgggca ccgacagttg acacatcgct taacgggaat gtcagtccgt
     6121 aagcgtggcg gctgaccaca aagacatcct gttgctgatc agtcgtgaag tatgcattgg
     6181 tgacaatcgc tgctgggtct ttcagcttca tcgccatcat cggcttactc ttgtacgtcc
     6241 gttgcggctg caaatcactt aaggcagttt gtttgatgta cccgtcactt gaccctaaca
     6301 caaaactgcc agcgccatcg agttgatcaa aagcaaacac tgccaagact ttttcgtcag
     6361 tgccaaggcc aactgtttgg cttaagtgtt cgccggtgtc tttccaacgc gcatcactaa
     6421 tttcatgcac tggtcgataa atgacatttc cggcatttgt cacgatgtaa agatgctgca
     6481 acgtactcag ttcgccagtg aaaatggcaa gatcattggc cttcaaacca ttgtcggccg
     6541 gatcaaccgc ctgataactg cgcagtgaac tgcgtttaac gtagccatca cgagaaacct
     6601 gcaccatgac ggtttcatca gccaccgtca ccgttgtcgc cacttcaagc gtttcaattt
     6661 tggcttgaat gctgctgcga cgatcatccc cgtactcctt ggcaatccgc ttcaactcgc
     6721 cttcaatcac ccgatcgcgg gcagcggggc gggccaaaat atcttgatac tcggcgattg
     6781 ctttcgccaa ttgtgctgct tctttctgta aagccgtgat atcggtattg gtcaatcgat
     6841 acagctgcaa ggaaacaatc gcttccgcct gagcttccga aaaatcaaac ttcttgacta
     6901 agttacgctt agcatcccct ttatccttgg aagcacgaat cgcggcgatg acctgatcca
     6961 aaatcgatag cattttgatc aagccttcga caatgtgctg tcgagcagcg gccttgttga
     7021 ggtcaaaacg cgttcgccga gtgaccacat cgcgtcgatg ttcgacgtat gcttccaaca
     7081 tggccttgag tcctagcaac ttcggctgca tgtcagcaat agcgaccatg ttaaagttgt
     7141 atgcaatttg cagatcggta tttttaaata aatagtttaa gatgccatgt gcatcggctt
     7201 ctttttttaa ttcgatgaca acgctaagcc caaaacggtc gctttcgtca cggacttcgg
     7261 cgataccgtc cacttttttg ttgatgcgta attcatcgat ttttttaatc atcagcgctt
     7321 tattgacatc atacgggatc tcagtgacca cgatcttctc acgaccgcca cgaatggttt
     7381 cgatgtgtgt ccgagaacga accacgattt taccgcggcc ggtttcgtaa gcttgcttga
     7441 taccatcaag cccttgaata atcccacctg ttggaaaatc gggacccttg acgtattgca
     7501 ttaaagtatc taaatcagca gtgggatgct tcagcaagta taagaccgca ttgatcactt
     7561 cgcgcaagtt atgcggcgga atttcggtcg cgtaacctgc agagatgccc gttgcaccat
     7621 tcaccagcaa attcggaaat cctgcgggca acacagttgg ttcctgtgcc gtgtcatcaa
     7681 agttcaacac catatcgacg gtttccttat cgatatcggc cagcatttcc ttgctgattt
     7741 tgcttaaacg cgcttccgta tatcgcattg cagctggcgg atcaccatcc atggaaccgt
     7801 tattcccgtg catctgaatc agtggggccc gtaacttcca atcctggctc agccgaacca
     7861 tcgcttcata aatggagctg tcgccgtggg gatgataatt acccatgaca ttcccgacac
     7921 ttttagccga cttgcggaag cccttatcat acgtattgcc atcttggttc atcgcaaata
     7981 aaatgcgacg ctgaaccggt ttgaggccgt cacgcacatc aggcagcgcc cgttcttgaa
     8041 taatgtattt cgagtaccgg ccaaaccggt cgcccatgac ctcttctaag gtcagttctt
     8101 gaatctgatt ggccaatggc ttttactttc ctttcttgtc cagttgtttg acgatttgct
     8161 tggcaccaaa ctgtaatttt tcgtgattag cagtcggggt ttccaaaata ctgccgtcgt
     8221 catccatatc aaacttgacg ttatgctcaa tccattcacg acgcggctca acgcgatcac
     8281 ccatcaaggt ggtcacgcgt cgctccgcca gctgagcatc gtcaatccga acccggatca
     8341 aagtccgcgt ctcaggattc atagtcgttt cccaaagctg atcggcattc atttccccaa
     8401 gtcctttaaa tcgggtcaat gtgtaaccct tgcccatggc tttggtctct ttggccaact
     8461 cttcatcggt ccaagcataa ctgatcttgg ttttagcacc agcgcctttt tgcagccggt
     8521 acaatggtgg caaagcaatg taaattcggc ctgcgtcaat cagcggccgc atgtagcgat
     8581 aaaagaaggt tagtagcaaa atctgaatat gcgcgccatc agtatccgca tcagtcataa
     8641 taatgatttt gtcgtagttg gcctgctgca gatcaaaatc cgcaccgaca ccagcgccga
     8701 tggtgtaaat catcgtattg atttcttcgt ttttaacgat gtcctgtaac ttggccttct
     8761 gggtattcag tactttccct cgcaatggca agatcgcctg aaacttccgg tctcggcctt
     8821 gtttagctga accaccggca gaatcccctt cgacaagata caattcatta cgcttaggat
     8881 tcttggtttg cgccggagtc aatttaccgg aaagcaaacc ttgatccttc ttgcgcttgc
     8941 gtcccgtccg gctatcatcg cgtgcttttc gagccgcttc tcgcgcatca cgggctttga
     9001 cggctttacg aaccaactct tgcgactctt caccgttttc catcaaaaaa gttgacagct
     9061 tgtcatagac aatcccatcg accacagtgc gggcttgcgg cgtaccaagc ttgccctttg
     9121 tctggccctc aaattgcaaa atttcttctg gaatgcggac acttaaaata cctgcaagac
     9181 cttcacgcac atcactgcct tcaaggttct tgtcgcgttc cttcaacaag ccgacttttc
     9241 gggcaaattc attgaatgct cgcgtcatgc cgctgcgcaa gccaatttca tgcgtcccgc
     9301 catcaccagt gcgaacgtta ttaacaaacg aaatcaggtt ttcagaatag ccatcgttat
     9361 attggccggc aaaatcaacc acgataccgt cctttttgcc ttcaaaattg atcacttgtg
     9421 acaatgcgtc tttgccttca ttaaggtatt taacaaaact gaccaagcca tcaggatagt
     9481 gataactgtc atgcttgccg gtgcgttcat ccgtcagatt aatcgtgata tttttcagta
     9541 gaaaggctga ttcgcgcaag cgttcggcca aggtatcata actgaaaaca gtggtttgaa
     9601 aaatagtcgg atccggctta aacgtgatgg tcgtgccatt cggttcgttg acttttccta
     9661 acttctgcag cgtgccatca ggatgaccgc cattgatgaa atgttcttca aatgcgcgct
     9721 tatcccgcac aactcgcacg gttaatgatt ccgatagggc attgacgacg cttgagccaa
     9781 ccccatgcaa accaccagaa gttttgtaac tattttggtt aaactttccg ccggcatgta
     9841 gcacggttaa aatgacttca atcgtcggtt tgccactcgg gtgcatcccc gttggcatcc
     9901 cgcgaccatg atcctgtacg gtcacagagt tatcggcgtg aatcgtcaca ttgatctcat
     9961 ccccaaaccc cgcgagcgct tcatcgacag agttgtccac gatttcatag accaagtgat
    10021 gcaaaccacg gccatcggtg gaaccaatat acatccctgg acgcttccgc acagcttcca
    10081 agccatgcag cacctgaatg gatgaatcat tatatgcttg cgttgcttta tccatagtaa
    10141 actccctttt ttgaacaact aagttataga atacaccacg cgttgagatt tcagaaataa
    10201 aaaataagag cgcgagcagg agcggttgct gcgactgtga gcgcgtttaa gcatcaacac
    10261 catcaacagc agacctcacc gtattgctct caggactcca gttttctcct caaaatcgac
    10321 ccagctggct aataccatca ttgttcattt aaattttatt agccgtgtca atgtcccaaa
    10381 gctcagcaga aaaccgcact tccctaagca tggcacataa ctatgacttc ttgacgtgaa
    10441 attcatcgcc cgctggcacc atatctacgc tgtgccccgc catgatcctt gcacaagacg
    10501 gcaccaaatc gcgccacaac ccgcttcaca ggttttattc gaatgtacgt tcgttttatt
    10561 ctactgacgt atcactcaaa agtcaaaaat gctaaaatag tttctagttt gagaggaggg
    10621 gcacatttga tacttgtgct ttgttttata ctcgcgtatt tcataggcgc catcccgttt
    10681 ggtgtggtca ttggtaaact cttttatcac acggatatcc gcaaaggcgg gagtcacaat
    10741 attggcacca caaatgctta tcgcatgtta gggccagtcg gcggctcaat tgtcttggtg
    10801 ctggatatct taaaaggcac gttggctgcc agcttaccca ttctctttgg catcgagcat
    10861 cattggctgg tgctgatcgt gggtttagcg gccgtattcg gtcatacatt ttcgatctac
    10921 attcgcttta aaggcggtaa ggcggtggca actagcgctg gcattttact tgcatataat
    10981 ccgccatttt ttgtcattgc atttgccatc tggtttagtt tgatcttgct aacgtccatg
    11041 gtcagcgttg ccagcacact gggtatggtg ttgatcacag tttggtcgct ggtttaccat
    11101 gattggttgc tgacaactgt tgcctgcggg ttgctggttg tctttttgat caaacatcgg
    11161 gcaaacttca aacgcatcaa ggccggagat gaaaatatgg tgccctttgg cttaggccaa
    11221 tatcttcgtc aacaccgggg ccgctcttag tcaccttttg atggcaacca aaaagacatc
    11281 cgaaactgga tgtctttttt tcatgtacct aatcgacaaa ctgatgacac cttagaaaat
    11341 gctgatcatg taacccttct gaaatgccgt gccaggttca agtcgattga tcccgagttt
    11401 gcgcgtcagg tcgccagtgc tgccaatcgt gtcggcgatg ccccaccaag gttcgatgca
    11461 gacaaagtcg cccgtggttg gatacggact ccaaacgccc agatatgggg tatcggtcat
    11521 ggtaacgctg acaccatgtt tcgtcttgtc agaaaccaag ttgaaggttg tcttaccaag
    11581 caacgcgaaa attaaagcat catgatcaaa tgtttcgtgc gttaaggcca aattggcatc
    11641 agttgcagcc aaggtccggt gcgtgtaatc aatgccttca ccagcaacca atggaatctg
    11701 aacaagcgac ttacgcggtt tgaagttcaa ataataatcg gagaatttag tatccggcgt
    11761 cattgggacc ttgaagcccg gatggccgcc gatgctaaag aacagtggct cacttttgtc
    11821 cggattgtca acgtgatacg tgacatgtag attgttattt tctagtgcaa acgtgatgat
    11881 taaacgaaaa gcgaacgggt acatcgcccg cgttttgtca tcatccttca gaacgaagct
    11941 cgctttaaac ggtgtcgcag agagcaccgt gaaatcacga tcacgggcaa aaccgtgctg
    12001 gcccatgtgg taagtcttgc ctgcgtaatg atattgattg tcagccagcg ccccaacaat
    12061 cgggaacaag accggggcgt ggcgacccca caccgcagga tctgcttgcc acagacgctc
    12121 cctgcctgtc aggttatctt tgatactggt cagttcagca ccatgccgac tgattttaac
    12181 tgtcaaaaag tcatttgcaa tcgttaccat acatcctcat cctttaccta caacattatt
    12241 gttaactaca aaatataccg cgtcatgttt gaatcagccg caatatggcc aatcttatca
    12301 tccacatatt gctgggtgac ggtcacagcg cccatcgcca tatctggacc ttcataaagt
    12361 acgtcttcaa gcagtttttc aagaatggtc gccagtcgcc gtgccccaat attatcagtg
    12421 tcgtggttga cctgagtcgc aatctctgca attcgatcaa ccgcttcctt cgtgaaggtg
    12481 atcttcacgc catctgcacc aatcaaggcg atatactgct tgatcaaagc attgtctggc
    12541 tcggtcaaga tccgcacaaa atctttttcg gttaagtcct tcaattcaac ccgaattgga
    12601 aaacgccctt gaagttcagc aatcaaatca ctaggcttag cctcggcaaa cgcacctgag
    12661 ccaatgaaca agatgtgatc agtattgata ggaccatact tagtgttaat ctgcgatcct
    12721 tctacaatcg gtaaaatatc tcgctgcaca ccttcacgcg aaacttcgcc gctattatgc
    12781 ttgtttcccg cagcaatttt atcgatttcg tcgatgaaaa tgatcccgtt attctcggca
    12841 ctttgaatgg cgtcgtgata aatgtcggca tgattgacca gtttgtcaga ttcctctttg
    12901 atgaagattt cgcgagcttc tttgacggtc atggtccgct caaccttttt cttaggcatt
    12961 aaagcgccaa tggtgtcgct tagatcaatg cccatctgac cgtacatgtc acccatgcca
    13021 ccgccttttt tctcatcatt gacagcaacg gtgatttcat gatcttcaag taatcctttt
    13081 tccagttgct ctgccacgct taaacgctta ttgcgaatat catcggtcac ttcgccgcct
    13141 gcgtctgcat catcgccagc tggcattttg ccattttgca ttccttgcaa catgctcatc
    13201 atctcggcca tcggattggt attcttttcc ttacgaatgg ccggcactaa aattttaacc
    13261 aaacgcttat tggcttcttt ttcggcacgt atgcgaacct ttgaaaattg cttctcttct
    13321 tccatggcaa cggcagtttc ggcaagatct cggaccatgg attcgacgtc acggccaacg
    13381 tagccaactt ccgtaaactt agtcgcttcc accttcacaa atggcgcctc aactattttc
    13441 gccagtcgtc gtgcaatttc ggttttcccg acaccggttg gtccgatcat cagtaagttt
    13501 ttcggggtaa tctcttcttg catttttggc gataattgca ttcgccgata acggttatac
    13561 aaggcaaccg cgacggcccg ttttgcatca tcttgtccaa tgacatattg atcgagtttt
    13621 tcaacgatct gttttggggt ttgtacttct gccatcataa gcctcctgta ggtcaatgta
    13681 attgccgacg gttacaaact aaaagctttc gacaataaca ttgtggtttg tgaaaatatc
    13741 gatattccct gcgatattca ccgcttcttt ggcaatgtca gctggtgtca tatctggggc
    13801 atgccgcagc atcgcgattg ccgcggcttg cgcaaagttg ccgccggagc cgatcgctac
    13861 cacgtcttca tctggatcta tcacttcgcc agatccggat acgagtaaca ggtcatgctc
    13921 atccatcacg atcatcatgg cctcaagttt ctgcaaggtc ggatccttgc gccaatcttg
    13981 agccagcgca actgcggaac gtcgcaagtt gccagcataa tgctccagct tcttttcaaa
    14041 ccagtcttgc agggtgaaag catctgccac cccgccggca aacccgatga cgacttgatc
    14101 atgatagatc cggcgaactt tctgcgcgtt gcctttcatg atgacctttt cgccaagggt
    14161 tacctgaccg tcaccggcca aagcggtcac accatctttt cttactgctg caattgttgt
    14221 catagtcatg ctccctttta agtgagcgcg agcagaatcg cttagaaacc ggagcataag
    14281 tgagctggaa gcctaaatgg ctgaattttg gctatttagg cttgcaggtc attatgtgta
    14341 ggtttctgcg actgcgagcg cgttatctgc gtatctcgtc ggataaaaac agctaaagta
    14401 gcgattaatc tgttatcgcc aatgttctta gcttaaaaaa ctcagactgc ttttgcatca
    14461 tgctttagtc ttaattatgc ttcggataat atttcatata ctcatttttt aaatgtgcca
    14521 tggtgacatg cgtgtagatt tgtgtggttg ataaacttgc atgacccagt agctcctgaa
    14581 cagttcgcag gtcagcacca tgatccagca tatgggttgc aaaactatgc cgcagcatgt
    14641 ggggatgaat gttagctgtc agcgtcgtct gcttgatgag ctgatccaaa atatattcaa
    14701 tgccacgcga ggtaatcgga tgcccatact ggttcacaaa tacatatcga tgctgtgcct
    14761 gacttttagc catcaagact tgtcggccat cttttaaata agttcgtagt gcttgctgag
    14821 cgtactgtcc aaagggcaca tacctatctt tgttgccttt accatgaatc aacagtaatg
    14881 ctgtattgaa atcgacctga ttcaatgtca gcttggcaca ctcggaaact cgaataccgg
    14941 taccatacaa aacttccaac aaagcgcgat tacgttgatc cagcggggtt ttgccagcaa
    15001 ctgtcttgaa cagttcctga atctcggctt catagaaaaa ttgtggtaaa tgatgatgct
    15061 gcttttttaa ttcaaccagc tcaaatgggt tgcgtttgac gacatcaatt cgtgtcaaat
    15121 aacggtaaaa gcttcgcaaa ctactgattt ttcgggcaat cgatgtccgt gccaaatcct
    15181 gtttgttaag atcagtcaaa taagtttgaa cgtctaaatc atccacatgc cgaaaatcag
    15241 taaacccgcc gttggccttg agaaacgctt gaaattcttg aagatcactc aaataagccg
    15301 tcactgtttc cggtgaatac tgccgttcaa cttcaagata ctcttgaaac gctgcaattg
    15361 gcttcattga atccctccga taatacatta acataaaatg cagccattgt tgacgctttc
//
