LOCUS       c00088_gnlPro..        16279 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|EIGOLAPF_110.
ACCESSION   c00088_gnlPro..
VERSION     c00088_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2025-04-29 22:06:19
            Original ID  :: gnl|Prokka|EIGOLAPF_110
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 81112
            Orig. end    :: 97391
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16279
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[91112:94357]"
                     /cutoff="2000"
                     /detection_rule="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /neighbourhood="10000"
                     /product="Pyruvate2acetate-formate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..13245
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="2000"
                     /detection_rule="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /neighbourhood="10000"
                     /product="Pyruvate2acetate-formate"
                     /protocluster_number="1"
     cand_cluster    1..16279
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /kind="single"
                     /product="Pyruvate2acetate-formate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16279
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Pyruvate2acetate-formate"
                     /region_number="1"
                     /rules="((PFL_acetate1 or PFL_acetate2) and Radical_SAM)"
                     /tool="gutsmash"
     CDS             998..1522
                     /locus_tag="ctg88_73"
                     /transl_table=11
                     /translation="MTTIAAVRKDGVTALAGDGQVTLGEKVIMKGNAQKVRRIYHDQVV
                     IGFAGGVADAFTLQDWFEKKLEHYAGNLRRSAVALAQDWRKDPTLQKLEAMMIVMDEHD
                     LLLVSGSGEVIDPDEDVVAIGSGGNFAQAAAIAMLRHAPDMTPADIAKEAVNIAGNIDI
                     FTNHNVIVESF"
     CDS             1566..2975
                     /locus_tag="ctg88_74"
                     /transl_table=11
                     /translation="MAEVQTPKQIVEKLDQYVIGQDDAKRAVAVALYNRYRRMQLSPKM
                     QEEITPKNLLMIGPTGVGKTEIARRLAKIVEAPFVKVEATKFTEVGYVGRDVESMVRDL
                     AETAVAMEEEKQFSKVRIRAEKEANKRLVKILVPAIRKEKNTNPMAEMMSMLQGMQNGK
                     MPAGDDADAGGEVTDDIRNKRLSVAEQLEKGLLEDHEITVAVNDEKKGGGMGDMYGQMG
                     IDLSDTIGALMPKKKVERTMTVKEAREIFIKEESDKLVNHADIYHDAIQSAENNGIIFI
                     DEIDKIAAGNKHNSGEVSREGVQRDILPIVEGSQINTKYGPINTDHILFIGSGAFAEAK
                     PSDLIAELQGRFPIRVELKDLTEKDFVRILTEPDNALIKQYIALIGADGVKITFTKEAV
                     DRIAEIATQVNHDTDNIGARRLATILEKLLEDVLYEGPDMAMGAVTVTQQYVDDKIGHI
                     AADSNMTRYIL"
     CDS             3011..3889
                     /locus_tag="ctg88_75"
                     /transl_table=11
                     /translation="MVTIANDFLTVKISRHGAELTSIKDNLTGRERLWQADPAVWGRHA
                     PVLFPIVGALADNQYHYAGKTYHMGQHGFARDRDFTVLSATPFKASFVLKDDDKTRAMY
                     PFAFRLIITFALENNNLHVTYHVDNPDKSEPLFFSIGGHPGFKVPMTPDTQFSDYYLNF
                     KPRKSLVQIPLVAGEGIDYTHRTLAATDANLALTHETFDHDALIFALLGKTTFNLVSDK
                     TKHGVSVTMTDTPYLGVWSPYPTTGDFVCIEPWWGIADTIGSTGDLTRKLGINRLEPGT
                     AFEKGYMISIF"
     CDS             complement(3971..4678)
                     /locus_tag="ctg88_76"
                     /transl_table=11
                     /translation="MYVRFILLTYHSKVKNAKIVSSLRGGAHLILVLCFILAYFIGAIP
                     FGVVIGKLFYHTDIRKGGSHNIGTTNAYRMLGPVGGSIVLVLDILKGTLAASLPILFGI
                     EHHWLVLIVGLAAVFGHTFSIYIRFKGGKAVATSAGILLAYNPPFFVIAFAIWFSLILL
                     TSMVSVASTLGMVLITAWSLVYHDWLLTTVACGLLVVFLIKHRANFKRIKAGDENMVPF
                     GLGQYLRQHRGRS"
     CDS             4958..5230
                     /locus_tag="ctg88_77"
                     /transl_table=11
                     /translation="MVLMPKRAHQPRNLRVRTLGTMVKAQPSRPRPLTLRLLTAPARAL
                     LKRVHQPRNLHIRTLGTMVKAQPSHPRPLMLRFLIGMARALIFYF"
     CDS             5286..7298
                     /locus_tag="ctg88_78"
                     /transl_table=11
                     /translation="MDKATQAYNDSSIQVLHGLEAVRKRPGMYIGSTDGRGLHHLVYEI
                     VDNSVDEALAGFGDEINVTIHADNSVTVQDHGRGMPTGMHPSGKPTIEVILTVLHAGGK
                     FNQNSYKTSGGLHGVGSSVVNALSESLTVRVVRDKHAFEEHFINGGHPDGSLQKLGKVN
                     EPNGTTITFKPDPTIFQTTVFSYDTLAERLRESAFLLKNITINLTDERTGKHDSYHYPD
                     GLVSFVKYLNEGKDALSQVINFEGKKDGIVVDFAGQYNDGYSENLISFVNNVRTGDGGT
                     HEIGLRSGMTRAFNEFARKVGLLKERDKNLEGSDVREGFAGILSVRIPEEILQFEGQTK
                     GKLGTPQARTVVDGIVYDKLSTFLMENGEESQELVRKAVKARDAREAARKARDDSRTGR
                     KRKKDQGLLSGKLTPAQTKNPKRNELYLVEGDSAGGSAKQGRDRKFQAILPLRGKVLNT
                     QKAKLQDIVKNEEINTMIYTIGAGVGADFDLQQANYDKIIIMTDADTDGAHIQILLLTF
                     FYRYMRPLIDAGRIYIALPPLYRLQKGAGAKTKISYAWTDEELAKETKAMGKGYTLTRF
                     KGLGEMNADQLWETTMNPETRTLIRVRIDDAQLAERRVTTLMGDRVEPRREWIEHNVKF
                     DMDDDGSILETPTANHEKLQFGAKQIVKQLDKKGK"
     CDS             7305..9749
                     /locus_tag="ctg88_79"
                     /transl_table=11
                     /translation="LANQIQELTLEEVMGDRFGRYSKYIIQERALPDVRDGLKPVQRRI
                     LFAMNQDGNTYDKGFRKSAKSVGNVMGNYHPHGDSSIYEAMVRLSQDWKLRAPLIQMHG
                     NNGSMDGDPPAAMRYTEARLSKISKEMLADIDKETVDMVLNFDDTAQEPTVLPAGFPNL
                     LVNGATGISAGYATEIPPHNLREVIAAVLYLLKHPTADLDTLMQYVKGPDFPTGGIIQG
                     LDGIKQAYETGRGKIVVRSRTHIETIRGGREKIVVTEIPYDVNKAQMIKKIDELRINKK
                     VDGIAEVRDESDRFGLSVVIELKKEADAHGILNYLFKNTDLQIAYNFNMVAIADMQPKL
                     LGLKAMLEAYVEHRRDVVTRRTRFDLNKAAARQHIVEGLIKMLSILDQVIAAIRASKDK
                     GDAKRNLVKKFDFSEAQAEAIVSLQLYRLTNTDITALQKEAAQLAKAIAEYQDILARPA
                     ARDRVIEGELKRIAKEYGDDRRSSIQAKIETLEVATTVTVADETVMVQVSRDGYVKRSS
                     LRSYQAVDPADNGLKANDLAIFTGELSTLQHLYIVTNAGNVIYRPVHEISDARWKDTGE
                     HLSQTVGLGTDEKVLAVFAFDQLDGAGSFVLGSSDGYIKQTALSDLQPQRTYKSKPMMA
                     MKLKDPAAIVTNAYFTTDQQQDVFVVSRHAYGLTFPLNDVSTVGARATGVKSMDLKPDD
                     EVVNFILVKDPTTAKVGILTQRGAFKKMALSEVGEMSRARRGLLVLRELKRDPHRIVAM
                     MSVDDATRLNVLTDTGKVTTLNPAQHPAGDRYSNGSFVIDTDVLGKPVFVQTKEEPADQ
                     VE"
     CDS             10001..12262
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Pyruvate2acetate-formate: PFL_acetate2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Gly_radical"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg88_80"
                     /sec_met_domain="Gly_radical (E-value: 3.3e-41, bitscore:
                     132.6, seeds: 99, tool: rule-based-clusters)"
                     /sec_met_domain="PFL_acetate2 (E-value: 1.4e-243, bitscore:
                     802.0, seeds: 33, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKQLDETKVPNYWEGFNGGDWQEEINVRDFIEHNLNQYDGDESFL
                     AGPTEATTVLNNQVLNLKKQERANGGVLDADNNIPSTITSHGPGYLNKDLEKIVGVQTD
                     KPFKRAFMPFGGIRMAEDALESYGFKTDPQEHKIFNEYRKTHNQGVFDAYTPDMRKARH
                     YKIVTGLPDAYGRGRIVSDFPRIAVYGIDRLMAEKFKDYNLTGDGEMTDDVIKLREEIN
                     EQYRALNDMKKMAKEYGYDISRPAANAQEAVQWIYFGYLAAVKTQNGAAMSVGRIDTVI
                     DAYIQRDMRLGKLNEEQAQELIDHLVMKLRMVRFIRTEEYNSLFSGDPIWATLSLAGMG
                     NDGRHHVTKTAFRFLKTLDNMGAAPEPNITLLWSERLPEGFKRYATEVSIQSSTIQYEN
                     DDLMRNEWGTDYYGIACCVSAQPIADGVQYFGARANLAKTVLYAINGGKDEIQEAQVGP
                     EYAPITSDYIDYKEFMNKFDKMMDWLADTYVNALNVIHYMHDKYYYEAAQLALKDTQLN
                     RTFATGISGLSHAVDSISAIKYGHVKAIRDENGVAVDFVADNDDYPRYGNNDDRADDIA
                     KWLVKTFYNKMNTHHLYRGAKLSTSVLTITSNVVYGKNTGTTPNGRQKGEPFSPGANPA
                     YGAEKNGALASLMSTAKIPYHYATDGISNTFGVTPNTLGHDDETRKDTLVHMVDGYMEN
                     SGMHLNINVFNKETLIDAQKHPEEYPTLTVRVSGYCVYFADLTKEQQDDVIARTFFEEM
                     "
     CDS             12394..13245
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Pyruvate2acetate-formate: Radical_SAM"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1015:4Fe-4S single cluster domain (Score: 65.2;
                     E-value: 2.4e-20)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg88_81"
                     /sec_met_domain="Radical_SAM (E-value: 2.2e-25, bitscore:
                     82.4, seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLIDQSQSPLNILEQVGQDHDGPIKGYVHSVESFGSVDGPGIRF
                     VVFMQGCRMRCQYCHNPDTWNIGVGEEMTADQILADAQRYKAFWGDQGGITCSGGESLV
                     QIDFILELFTKAKALGISTCLDTSGGPFTRDQPWFGQFEKLMAVTDISLVDIKHIDSAE
                     HKKLTGFPNENILDMVQYMSAHGDDMWIRHVLVPERTDFDPYLKRLGDYIATLDKNVVQ
                     KVEILPYHTLGVKKYHELGITYPLEGIEPPSADRVKNAENLLHVKDYTGWQSWRPKPVA
                     SN"
     CDS             13370..14338
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LysR_substrate"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HTH_1"
                     /gene_functions="regulatory (smcogs) SMCOG1012:Bacterial
                     regulatory helix-turn-helix protein, lysR family (Score:
                     60.8; E-value: 3.2e-19)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg88_82"
                     /sec_met_domain="LysR_substrate (E-value: 1.3e-26,
                     bitscore: 85.7, seeds: 361, tool: rule-based-clusters)"
                     /sec_met_domain="HTH_1 (E-value: 4.3e-19, bitscore: 60.8,
                     seeds: 1330, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTKQERIFSSKTLTYFLQLAETMNYTQAAQLLGITQPALTQQIK
                     KLERTVGAPLFYSVGKKLHLSDAGQTMLKSTHEIYEILNQTTDEIQQTTSATVGKINIG
                     LLSSIEDSAFIAFIAHYYQLNPEVEVTLRMMTRHEIWESLENNQIDLAIMNLPDETIKN
                     WKPYASKKIIDEQLLFLHHDDALANRKRIHFKDTLAEPWATYPDDYFLGQLLREAYKNQ
                     MVDFPHVVAHFTTPYQLTQFVNLSGVNTALPTSFVRARADQIKAYAIAFDPAIRFEISF
                     VYRKEKADIPRISNFFQTFDDYLKEKDYLSRVSENRVKLDK"
     CDS             14368..15300
                     /locus_tag="ctg88_83"
                     /transl_table=11
                     /translation="MTTLIFGHQNPDTDAITSAMSWAEFQKQAGNTDVEAVALGEPNDE
                     TKFVLDHFKVQAPRVIKTAANETDHVMLVDHNEFQQSVSDIEDVTIDSVVDHHRIANFH
                     TAAPLFYRAEPVGSTNTVIFEMFQEYGFKISPTLAGLMASGLISDTLLLKSPTATDKDK
                     KILPEMAKIAGIDLQSYGLAMLKAGTNLAAKSDMDIIEGDAKSFTMGGKSIRIGQVNTV
                     DLNDIYARQDELISAMTKEAQAKGYDDFLLIATDILDSNSTGFAVGADRDKIASAFNEQ
                     FDKDARLALPGVVSRKKQVVPPMQSTFEG"
ORIGIN
        1 gatgatttag acgttcaaac ttatttgact gatcttaaca aacaggattt ggcacggaca
       61 tcgattgccc gaaaaatcag tagtttgcga agcttttacc gttatttgac acgaattgat
      121 gtcgtcaaac gcaacccatt tgagctggtt gaattaaaaa agcagcatca tcatttacct
      181 caatttttct atgaagccga gattcaggaa ctgttcaaga cagttgctgg caaaaccccg
      241 ctggatcaac gtaatcgcgc tttgttggaa gttttgtatg gcaccggtat tcgagtttcc
      301 gagtgtgcca aactgacatt gaatcaggtc gatttcaata cggcattact gttgattcat
      361 ggtaaaggca acaaagatag gtatgtgccc tttggacagt acgcccagca agcactacga
      421 acctatttaa aagatggtcg acaagttttg atggctaaaa gtcaggcaca gcatcgatat
      481 gtattcgtga accagtatgg gcgtccgatt acctcgcgtg gcattgaata tattttggat
      541 cagctcatca agcagacgac gctgacagct aacattcatc cccacatgct gcggcatagt
      601 tttgcaaccc atatgctgga tcatggtgct gacctgcgaa ctgttcaaga gctactgggt
      661 catgcaagtt tatcaaccac acaaatctac acgcatgtca ccatggcaca tttaaaaaat
      721 gagtatatga aatattatcc gaagcataat taagactaaa gcatgatgca aaagcagtct
      781 gagtttttta agctaagaac attggcgata acagattaat cgctacttta gctgttttta
      841 tccgacgaga tacgcagata acgcgctcgc agtcgcagaa acctgcacat aatgacctgg
      901 aagcctaaat agccaaaatt cagccattta ggctagccca cttatgctcc ggtttctaag
      961 cgcttctgct cgcgctcact taaaaaggag catgactatg acaacaattg cagcagtaag
     1021 aaaagatggt gtgaccgctt tggccggtga cggtcaggta acccttggcg aaaaggtcat
     1081 catgaaaggc aacgcgcaga aagttcgccg gatctatcat gatcaagtcg tcatcggatt
     1141 tgccggcggg gtggcagatg ctttcaccct gcaagactgg tttgaaaaga agctggagca
     1201 ttatgcgggc aacttgcgac gttccgcagt tgcgctggct caagattggc gcaaggatcc
     1261 gaccttgcag aaacttgagg ccatgatgat cgtgatggat gagcatgacc tgttactcgt
     1321 atccggatct ggcgaagtga tagatccaga tgaagacgta gtagcgatcg gctccggcgg
     1381 caactttgcg caagccgcgg caatcgcgat gctgcggcat gccccagata tgacaccagc
     1441 tgacattgcc aaagaagcgg tgaatatcgc aggaaatatc gatattttca caaaccacaa
     1501 tgttattgtc gaaagctttt agtttgtaac cgtcggcaat tacattgacc tacaggaggc
     1561 ttatgatggc agaagtacaa accccaaaac agatcgtcga aaaactcgat caatatgtca
     1621 ttggacaaga tgatgcaaaa cgggccgtcg cggttgcctt gtataaccgt tatcggcgaa
     1681 tgcaattatc gccaaaaatg caagaagaga ttaccccgaa aaacttactg atgatcggac
     1741 caaccggtgt cgggaaaacc gaaattgcac gacgactggc gaaaatagtt gaggcgccat
     1801 ttgtgaaggt agaagcgact aagtttacgg aagttggcta cgttggccgt gacgtcgaat
     1861 ccatggtccg agatcttgcc gaaactgccg ttgccatgga agaagagaag caattttcaa
     1921 aggttcgcat acgtgctgaa aaagaagcca acaagcgttt ggttaaaatt ttagtgccgg
     1981 ccattcgtaa ggaaaagaat accaatccga tggccgagat gatgagcatg ttgcaaggga
     2041 tgcaaaatgg caaaatgcca gctggcgatg atgcagacgc aggcggcgaa gtgaccgatg
     2101 atattcgcaa taagcgtttg agcgtggcag agcaactgga aaaaggatta cttgaagatc
     2161 atgaaatcac cgttgctgtc aatgatgaga aaaaaggcgg tggcatgggt gacatgtacg
     2221 gtcagatggg cattgatcta agcgacacca ttggcgcttt aatgcctaag aaaaaagttg
     2281 agcggaccat gaccgtcaaa gaagctcgcg aaatcttcat caaagaggaa tctgacaaac
     2341 tggtcaatca tgccgacatt tatcacgacg ccattcaaag tgccgagaat aacgggatca
     2401 ttttcatcga tgaaatcgat aaaattgctg cgggaaacaa gcataatagc ggcgaagttt
     2461 cgcgtgaagg tgtgcagcga gatattttac cgattgtaga aggatcgcag attaacacta
     2521 agtatggtcc tatcaatacg gatcacatct tgttcattgg ctcaggtgcg tttgccgagg
     2581 ctaagcctag tgatttgatt gctgaacttc aagggcgttt tccaattcgg gttgaattga
     2641 aggacttaac cgaaaaagac tttgtgcgga tcttgaccga gccagacaat gctttgatca
     2701 agcagtatat cgccttgatt ggtgcagatg gcgtgaagat taccttcacg aaggaagcgg
     2761 ttgatcgaat tgcagagatt gcgactcagg tcaaccacga cactgataat attggagcgc
     2821 ggcgactggc gaccattctt gaaaaactgc ttgaagacgt actttatgaa ggtccagata
     2881 tggcgatggg cgctgtgacc gtcacccagc aatatgtgga tgacaagatt ggccatattg
     2941 cggctgattc aaacatgacg cggtatattt tgtagttaac aataatgttg taggtaaagg
     3001 atgaggatgt atggtaacga ttgcaaatga ctttttgaca gttaaaatca gtcggcatgg
     3061 tgctgaactg accagtatca aagataacct gacaggcagg gagcgtctgt ggcaagcaga
     3121 tcctgcggtg tggggtcgcc acgccccggt cttgttcccg attgttgggg cgctggctga
     3181 caatcaatat cattacgcag gcaagactta ccacatgggc cagcacggtt ttgcccgtga
     3241 tcgtgatttc acggtgctct ctgcgacacc gtttaaagcg agcttcgttc tgaaggatga
     3301 tgacaaaacg cgggcgatgt acccgttcgc ttttcgttta atcatcacgt ttgcactaga
     3361 aaataacaat ctacatgtca cgtatcacgt tgacaatccg gacaaaagtg agccactgtt
     3421 ctttagcatc ggcggccatc cgggcttcaa ggtcccaatg acgccggata ctcaattctc
     3481 cgattattat ttgaacttca aaccgcgtaa gtcgcttgtt cagattccgt tggttgctgg
     3541 tgaaggcatt gattacacgc accggacctt ggctgcaact gatgccaatt tggccttaac
     3601 gcacgaaaca tttgatcatg atgctttaat tttcgcgttg cttggtaaga caaccttcaa
     3661 cttggtttct gacaagacga aacatggtgt cagcgttacc atgaccgata ccccatatct
     3721 gggcgtttgg agtccgtatc caaccactgg cgactttgtc tgcatcgaac cttggtgggg
     3781 catcgccgac acgattggca gcactggcga cctgacgcgc aaactcggga tcaatcgact
     3841 tgaacctggc acggcatttg agaagggtta catgatcagc attttctaag gtgtcatcag
     3901 tttgtcgatt aagtacatga aaaaaagaca tccagtttcg gatgtctttt tggttgccat
     3961 caaaaggtga ctatgagcgg ccccggtgtt gacgaagata ttggcctagg ccaaagggca
     4021 ccatattttc atctccggcc ttgatgcgtt tgaagtttgc ccgatgtttg atcaaaaaga
     4081 caaccagcaa cccgcaggca acagttgtca gcaaccaatc atggtaaaca agcgaccaag
     4141 ctgtgatcaa caccataccc agtgtgctgg caacgctgac catggacgtt agcaagatca
     4201 aactaaacca gatggcaaat gcaatgacaa aaaatggcgg attatatgca agtaaaatgc
     4261 cagcgctagt tgccaccgcc ttaccgcctt taaagcgaat gtagattgaa aatgtatgac
     4321 cgaatacggc cgctaaaccc acgatcagca ccagccaatg atgctcgatg ccaaagagaa
     4381 tgggtaagct ggcagccaac gtgcctttta agatatccag caccaagaca attgagccgc
     4441 cgactggccc taacatgcga taagcatttg tggtgccaat attgtgactc ccgcctttgc
     4501 ggatatccgt gtgataaaag agtttaccaa tgaccacacc aaacgggatg gcgcctatga
     4561 aatacgcgag tataaaacaa agcacaagta tcaaatgtgc ccctcctctc aaactagaaa
     4621 ctattttagc atttttgact tttgagtgat acgtcagtag aataaaacga acgtacattc
     4681 gaataaaacc tgtgaagcgg gttgtggcgc gatttggtgc cgttttgtgc aaggatcatg
     4741 gcggggcaca gcgtagatat ggtgccagcg ggcgatgaat ttcacgtcaa gaagtcatag
     4801 ttatgtgcca tgcttaggga agtgcggttt tctgctgagc tttgggacat tgacacggct
     4861 aataaaattt aaatgaacaa tgatggtatt agccggctgg gtcgattttg aggagaaaac
     4921 aggagttctg agagcaatac ggtgaggtct gctgttgatg gtgttgatgc ctaaacgcgc
     4981 tcaccagccc agaaacctgc gtgtaaggac cttgggcaca atggtcaaag cccaaccatc
     5041 acgtccaagg ccgcttacac tccggttgct aaccgcccct gctcgcgctc tactgaaacg
     5101 cgttcaccag cccagaaacc tgcacataag gaccttgggc acaatggtca aagcccaacc
     5161 atcgcaccca aggccgctta tgctccggtt tctaatcggg atggctcgcg ctcttatttt
     5221 ttatttctga aatctcaacg cgtggtgtat tctataactt agttgttcaa aaaagggagt
     5281 ttactatgga taaagcaacg caagcatata atgattcatc cattcaggtg ctgcatggct
     5341 tggaagctgt gcggaagcgt ccggggatgt atattggatc caccgatggc cgcggtttgc
     5401 atcacttggt ctatgaaatc gtggacaact ctgtcgatga agcgctcgcg gggtttgggg
     5461 atgagatcaa tgtgacgatt cacgccgata actctgtgac cgtacaggat catggtcgcg
     5521 ggatgccaac ggggatgcac ccgagtggca aaccgacgat tgaagtcatt ttaaccgtgc
     5581 tacatgccgg cggaaagttt aaccaaaata gttacaaaac ttctggtggt ttgcatgggg
     5641 ttggctcaag cgtcgtcaat gccttatcgg agtcattgac tgtgcgagtt gtgcgggata
     5701 agcacgcatt tgaggagcat tttatcaatg gcggtcatcc tgatggcagt ttgcagaagt
     5761 tgggcaaagt taatgaacct aatggcacga ccatcacgtt caagccggac ccgactattt
     5821 ttcaaaccac cgtcttcagt tatgatacct tggccgaacg cttgcgcgaa tcagcctttc
     5881 tactgaaaaa tattacgatt aatctgacgg atgaacgcac cggcaagcat gacagttatc
     5941 actatcctga tggcttggtc agttttgtta aataccttaa tgaaggcaaa gacgcattgt
     6001 cacaggtgat caattttgaa ggcaaaaagg acggtatcgt ggttgatttt gccggccaat
     6061 ataacgatgg ctattctgaa aacctgattt cgtttgttaa taacgttcgc actggtgatg
     6121 gcgggacgca tgaaattggc ttgcgcagcg gcatgacccg tgcattcaat gagtttgccc
     6181 gaaaagtcgg cttgctgaag gaacgcgaca agaaccttga aggcagtgat gtgcgtgaag
     6241 gttttgcagg tattttaagt gtccgcattc cagaagaaat tttgcaattt gagggccaga
     6301 caaagggcaa gcttggtacg ccgcaagccc gcactgtggt cgatgggatt gtctatgaca
     6361 agctgtcaac ttttttgatg gaaaacggtg aagagtcgca agagttggtt cgtaaagccg
     6421 tcaaagcccg tgatgcgcgg gaagcggctc gaaaagcacg cgatgatagc cggacgggac
     6481 gcaagcgcaa gaaggaccaa ggtttgcttt ccggtaaatt gaccccggcg caaaccaaga
     6541 accctaagcg taacgaattg tatctcgtcg aaggggattc tgccggtggt tcagctaaac
     6601 aaggccgaga ccggaagttt caggcgatct tgccattgcg agggaaagta ctgaataccc
     6661 agaaggccaa gttacaggac atcgttaaaa acgaagaaat caatacgatg atttacacca
     6721 tcggcgctgg tgtcggtgcg gattttgatc tgcagcaggc caactacgac aaaatcatta
     6781 ttatgactga tgcggatact gatggcgcgc atattcagat tttgctacta accttctttt
     6841 atcgctacat gcggccgctg attgacgcag gccgaattta cattgctttg ccaccattgt
     6901 accggctgca aaaaggcgct ggtgctaaaa ccaagatcag ttatgcttgg accgatgaag
     6961 agttggccaa agagaccaag gccatgggca agggttacac attgacccga tttaaaggac
     7021 ttggggaaat gaatgccgac cagctttggg aaacgactat gaatcctgag acgcggactt
     7081 tgatccgggt tcggattgac gatgctcagc tggcggaacg acgcgtgacc actttgatgg
     7141 gtgatcgcgt tgagccgcgt cgtgaatgga ttgagcataa cgtcaagttt gatatggatg
     7201 acgacggcag tattttggaa accccgactg ctaatcacga aaaattacag tttggtgcca
     7261 agcaaatcgt caaacaactg gacaagaaag gaaagtaaaa gccattggcc aatcagattc
     7321 aagaactgac cttagaagag gtcatgggcg accggtttgg ccggtactcg aaatacatta
     7381 ttcaagaacg ggcgctgcct gatgtgcgtg acggcctcaa accggttcag cgtcgcattt
     7441 tatttgcgat gaaccaagat ggcaatacgt atgataaggg cttccgcaag tcggctaaaa
     7501 gtgtcgggaa tgtcatgggt aattatcatc cccacggcga cagctccatt tatgaagcga
     7561 tggttcggct aagccaggat tggaagttac gggccccact gattcagatg cacgggaata
     7621 acggttccat ggatggtgat ccgccagctg caatgcgata cacggaagcg cgtttaagca
     7681 aaatcagcaa ggaaatgctg gccgacatcg ataaggaaac cgtcgatatg gtgttgaact
     7741 ttgatgacac ggcacaggaa ccgactgtgc tgccagctgg gtttccaaat ttgctggtga
     7801 acggtgccac cggtatttct gccggttatg caaccgaaat tccgccgcac aatctgcggg
     7861 aagttattgc tgccgtctta tacttgctga agcatcccac tgctgattta gatactttaa
     7921 tgcaatacgt caagggtccc gattttccaa caggtgggat tattcaaggg cttgatggca
     7981 tcaagcaagc ttacgaaacc ggccgcggta aaatcgtggt tcgttctcgg acacacatcg
     8041 aaaccattcg tggcggtcgt gagaagatcg tggtcactga gatcccgtat gatgtcaata
     8101 aagcgcagat gattaaaaaa atcgatgaat tacgcatcaa caaaaaagtg gacggtatcg
     8161 ccgaagtccg tgacgaaagc gaccgttttg ggcttagcgt tgtcatcgaa ttaaaaaaag
     8221 aagccgatgc acatggcatc ttaaactatt tatttaaaaa taccgatcta caaattgcat
     8281 acaactttaa catggtcgct attgccgaca tgcagccgaa gttgctagga cttaaggcca
     8341 tgttggaagc atacgtcgaa catcgacgcg atgtggtcac tcggcgaacg cgttttgacc
     8401 tcaacaaggc cgctgctcga cagcacattg tcgaaggctt gatcaaaatg ctatcgattt
     8461 tggatcaggt catcgccgcg attcgtgctt ccaaggataa aggggatgct aagcgtaact
     8521 tagtcaagaa gtttgatttt tcggaagctc aggcggaagc gattgtttcc ttgcagctgt
     8581 atcgattgac caataccgat atcacggctt tacagaaaga agcagcacaa ttggcgaaag
     8641 caatcgccga gtatcaagat attttggccc gccccgctgc ccgcgatcgg gtgattgaag
     8701 gcgagttgaa gcggattgcc aaggagtacg gggatgatcg tcgcagcagc attcaagcca
     8761 aaattgaaac gcttgaagtg gcgacaacgg tgacggtggc tgatgaaacc gttatggtgc
     8821 aggtttctcg tgatgggtac gttaaacgca gttcactgcg cagttatcag gcggttgatc
     8881 cggccgacaa tggtttgaag gccaatgatc ttgccatttt cactggcgaa ctgagtacgt
     8941 tgcagcatct ttacatcgtg acaaatgccg gaaatgtcat ttatcgacca gtgcatgaaa
     9001 ttagtgatgc gcgttggaaa gacaccggcg aacacttaag ccaaacagtt ggccttggca
     9061 ctgacgaaaa agtcttggca gtgtttgctt ttgatcaact cgatggcgct ggcagttttg
     9121 tgttagggtc aagtgacggg tacatcaaac aaactgcctt aagtgatttg cagccgcaac
     9181 ggacgtacaa gagtaagccg atgatggcga tgaagctgaa agacccagcc gcgattgtca
     9241 ccaatgcata cttcacgact gatcagcaac aggatgtctt tgtggtcagc cgccacgctt
     9301 acggactgac attcccgtta aacgatgtgt caactgtcgg tgcccgggca accggcgtta
     9361 aaagtatgga tctaaagcca gacgatgagg ttgtcaattt cattctagtg aaggatccaa
     9421 ctacggctaa ggtcggtatt ttgacccaac gtggcgcctt caaaaagatg gcattaagcg
     9481 aggtcgggga aatgagtcgt gcccgtcgtg gtttactggt cttgcgtgag cttaagcgtg
     9541 atccgcatcg gattgtcgcg atgatgtcag tcgatgacgc tacccgcctg aatgttttga
     9601 ccgatacggg taaggtaacg acccttaatc cggcacaaca tccagcaggt gaccgctatt
     9661 cgaatggttc gtttgtcatt gacactgatg tccttggcaa gccagttttt gttcaaacca
     9721 aagaagaacc agcagatcaa gtcgaataaa tggtgatcat tgacgccgcc gtctgtacta
     9781 atacagatgg cggcgttttt gattattata ggacagatca gttgtgcaca acttaacaaa
     9841 atgtcgaaat catgggcgaa aagaagcgac gaagcacact taaaaaacaa tataacgcct
     9901 attatatggg caataaaacg cttgcataga tttggcggcg tgttatactg tgtttgtaag
     9961 aactgtcaca tctgtaatcc actttaggag gcaaacaact atgaaacagc ttgacgaaac
    10021 caaagttcct aattattggg aaggctttaa cggcggcgac tggcaagaag aaattaatgt
    10081 gcgcgatttt atcgagcata acctgaacca atatgacggg gacgaaagtt tccttgctgg
    10141 ccccactgaa gcgacaacag tcctgaacaa tcaggttcta aatttaaaga agcaagaacg
    10201 tgcaaatggc ggtgttttgg atgctgacaa caatattcca tctacgatca cctcacacgg
    10261 ccctggttat ttgaacaaag atcttgaaaa gattgttggt gttcagaccg acaagccatt
    10321 caaacgagca ttcatgccat ttggcggtat tcgaatggct gaagatgcat tggaatctta
    10381 tggcttcaag acagatcctc aagaacacaa gattttcaat gaatatcgta agacccataa
    10441 tcaaggtgtc tttgatgctt atacccctga tatgcgaaag gctcgccatt acaagatcgt
    10501 gactggcttg ccagacgcat acggccgtgg ccggattgtt tctgatttcc cacggatcgc
    10561 tgtttacggg atcgatcgtt tgatggccga gaagttcaag gattataact tgactggcga
    10621 cggcgaaatg actgacgatg tgatcaaact gcgtgaagaa atcaatgaac aatatcgtgc
    10681 cttaaacgac atgaagaaga tggccaagga atatggctat gacatctcgc gtcctgcagc
    10741 taatgcgcaa gaagctgttc agtggatcta ctttggctat ctggctgctg ttaagactca
    10801 aaacggtgcc gcaatgtccg ttggccggat cgatacggtt attgatgctt atatccaacg
    10861 cgatatgcgc ttaggcaagt tgaacgaaga acaggcacag gaactgattg atcatttggt
    10921 tatgaaattg cggatggttc gtttcatccg gactgaagaa tataactcac tgttctcagg
    10981 cgatccaatc tgggcaacct tgtcattggc aggaatgggc aatgatggcc gtcaccacgt
    11041 taccaagacg gctttccgtt tcctgaagac tttggacaac atgggcgcag caccagaacc
    11101 aaacatcacc ttgctttgga gcgaacgctt gccagaagga ttcaaacgct atgcaaccga
    11161 agtatccatc caaagttcaa ccattcaata tgaaaatgat gatctgatgc gcaacgaatg
    11221 gggtaccgat tactacggta ttgcttgctg tgtctcagca caaccaattg ctgatggcgt
    11281 tcaatacttt ggtgcccgtg ctaacttagc taagacagtt ctgtatgcga tcaacggtgg
    11341 gaaagatgaa attcaggaag cgcaagtagg gcctgaatat gcaccgatca ccagcgatta
    11401 cattgattac aaagaattca tgaataagtt cgacaagatg atggactggc tggccgacac
    11461 gtatgtcaat gctttgaatg tgattcacta tatgcatgac aagtattatt atgaagctgc
    11521 acagctggca ttgaaggata cccaactgaa ccggaccttc gcaaccggga tttccggcct
    11581 gtcacacgcg gttgattcca tcagtgcaat caagtatggt catgtcaagg caattcgcga
    11641 tgaaaacggt gttgcagttg acttcgttgc tgacaatgat gactatccac gttatggtaa
    11701 caacgatgat cgcgctgatg acatcgctaa gtggttggtt aagaccttct ataacaagat
    11761 gaacacgcat catctgtatc gcggcgcgaa gttgagcacc agtgtcctga ccattacctc
    11821 caacgtggtt tatggtaaga atacagggac aacaccaaac ggtcgtcaaa aaggcgaacc
    11881 attctcacca ggtgccaacc cggcatatgg cgcagaaaag aacggcgcac tggcatccct
    11941 gatgtccacc gccaagattc cgtatcatta cgcaactgac ggcattagta atacgtttgg
    12001 ggttactccg aacacactgg gccacgatga tgaaactcgt aaggatacct tggttcacat
    12061 ggttgacggc tatatggaaa acagcggcat gcatttgaac atcaacgtct tcaataagga
    12121 gactctgatt gatgctcaga agcacccaga agaataccca acattgaccg ttcgggtttc
    12181 tggctactgc gtctacttcg cagatttgac caaggaacaa caagacgatg tcattgctcg
    12241 gaccttcttc gaagaaatgt aagcagctta actcaagaca ggaagccatt cctgttttgc
    12301 caaaagacgg caacgatgct gttgccgttt tttggcagaa tgaaatgaaa atcaattgaa
    12361 aacgacacat gatgttgtag tggaggcaat aagatgaaac tcatcgatca gtcacaaagc
    12421 ccattaaata tcttagaaca agttggtcag gatcatgatg gcccgatcaa agggtatgtt
    12481 cactcggtcg aaagttttgg ttcggtcgat ggccctggta ttcgcttcgt tgtctttatg
    12541 caagggtgtc gcatgcgttg ccagtattgt cacaaccctg acacctggaa cattggggtt
    12601 ggtgaagaaa tgacggccga tcaaattttg gcggatgccc agcgctataa agcattctgg
    12661 ggtgaccaag ggggtattac ctgcagtggc ggtgagagtt tggtacaaat cgatttcatt
    12721 ctcgaactct tcaccaaggc taaggcactg ggaatttcga cttgcctcga tacgtcaggt
    12781 ggccccttca cgcgtgacca accgtggttt ggccagtttg aaaagctgat ggctgttact
    12841 gacatctcat tagttgatat taaacacatt gattcggccg agcataaaaa gctcaccggt
    12901 tttcctaatg agaatatttt ggatatggtg cagtatatgt cggcgcatgg tgatgacatg
    12961 tggattcgcc acgttctggt cccggaacgc actgactttg acccttatct caaacggtta
    13021 ggggactata ttgcgacatt ggacaaaaac gtggtccaaa aagttgagat tctgccgtat
    13081 cacacgttag gcgttaaaaa gtatcacgag cttggcatta cgtacccgct tgaaggcatc
    13141 gaaccgccgt ctgccgatcg cgttaagaat gcagagaatc tgctgcacgt taaggattat
    13201 accggatggc aaagctggcg tccgaaacca gttgcgagca actgaatttt tagctagaac
    13261 ttaacgtaac gattaaaaac gcggcaaatt cgttgcgttt tttttcattg ccacttatga
    13321 tgatggttga acgatattat taaattataa acgaaaggga agccgcccta tgaaaacgaa
    13381 acaagagcgc attttttcct caaagacact aacttatttt ctgcaattgg cagaaaccat
    13441 gaactacacc caagccgccc aattgcttgg cattacccag ccagccttaa cacagcagat
    13501 caagaaattg gaacggacgg tgggggcacc gctgttttat tctgtcggga agaaactgca
    13561 tttatctgac gctggtcaga ccatgttaaa gtcaacccat gagatctacg agatcttgaa
    13621 ccagacaacc gacgaaattc aacaaacaac cagtgcaacc gtcggaaaaa tcaatattgg
    13681 gttattaagc tcaattgagg atagcgcctt tattgcgttc attgctcatt actatcaact
    13741 gaatcctgaa gttgaagtaa cgctacggat gatgacccgt cacgaaattt gggaatcatt
    13801 ggaaaacaac cagattgatt tggctatcat gaatctgcca gatgagacca ttaagaactg
    13861 gaaaccatac gccagcaaga aaattattga tgaacaattg ctgttcttgc accacgatga
    13921 cgccttggct aaccgtaagc gaatccattt caaagatact ttagctgaac cttgggcaac
    13981 ttatcctgac gactatttcc ttggacagct tctgcgtgag gcgtacaaga atcaaatggt
    14041 tgatttcccg cacgtggtcg cacatttcac cacgccatat cagttaaccc aattcgttaa
    14101 cttgtcaggg gtcaacacgg ccttaccaac cagttttgtt cgggcacgcg ctgatcaaat
    14161 caaggcctat gctattgcgt ttgatccggc cattcgcttt gagatttctt ttgtttatcg
    14221 caaagagaaa gctgacattc cgcggatctc gaacttcttc cagacctttg acgattatct
    14281 gaaggaaaaa gattacttgt cgcgggtcag tgaaaaccgt gttaaacttg ataagtaaac
    14341 tattcagttg aggagcgatc agataagatg acgactttga tttttgggca tcagaacccg
    14401 gacaccgacg cgattacgag tgccatgagc tgggcagaat ttcagaaaca ggcaggcaac
    14461 acggatgttg aggcggtagc attaggcgaa ccgaacgatg agactaagtt tgtccttgat
    14521 cacttcaagg ttcaggcacc gcgggttatc aagacggcag ccaacgagac ggatcatgtc
    14581 atgttggttg atcacaacga atttcaacaa agtgtcagtg atatcgaaga cgtgacgatt
    14641 gattctgttg tcgaccatca tcgcatcgct aacttccaca cggcagcgcc gctgttttac
    14701 cgagcagaac cggttggcag caccaatacc gtcatttttg agatgttcca ggaatatggc
    14761 ttcaagattt cgccaacatt ggctggtttg atggcttctg gtttgatttc agacacgctg
    14821 ttgttgaagt cgccgaccgc aaccgacaag gataagaaga ttttgccaga aatggcgaag
    14881 attgccggaa ttgatttgca gtcatatggt cttgccatgc tgaaggcagg cactaatttg
    14941 gccgccaagt cagatatgga cattatcgaa ggcgatgcta agagtttcac catgggcggc
    15001 aagtctattc gcatcggaca ggtcaatacc gtcgatctga acgacattta cgcacgtcag
    15061 gacgaattga tcagtgccat gaccaaagag gcgcaggcga aaggctacga cgatttcctg
    15121 ctgattgcca ctgacatctt ggacagcaat tcaactggtt tcgcagtcgg tgctgaccgc
    15181 gataaaatcg ccagtgcttt caacgaacag ttcgacaagg acgcgcgttt ggcattgcct
    15241 ggggttgttt cccgcaaaaa gcaggtcgtt ccgccaatgc agagcacgtt tgaaggttaa
    15301 ctttcatctt taattgcaca caattgttct aaggtaagtc gcagctagcc agttgcggct
    15361 tttttgtttg caaaaagtct ctagccatct ttttgcgaaa tctgttaaat ataaagctgg
    15421 ctagcagttc gtgatgcgtg aatttgaaat ttgtgtagca attcgcgggt cgaatcaaca
    15481 gcaagttgtc atgggtcatt ttggatggtt ttgaggcatg ctgagagacg cattctgaga
    15541 cgagttcggg aattcaactt gatagtttga cttaacgaaa aaactcaagc aaaaaatatc
    15601 caatgattta tccaaagatt gtagaagctt ttaaagactt ggctgcaagc agcggttcaa
    15661 aaaatgaggc gactatcagg tgctgtatga aattgcgaat caaataatcg ccaacgtaaa
    15721 tattgcgaga atggcacgat gccgtctctt caaacgctac ttcgcataat atatattatg
    15781 taaactagaa tataaataat tggctttggc acttgatctg cgaatctggg tgtcccctct
    15841 ttcagatggc tgtcaaaaat ttgtggtccg gacgtaatgt tggtggtggc gattgcattt
    15901 tttaccaagg caatcaatta tgacttggaa cgttgcgttt acgctgagtt gcatgcattt
    15961 gtttgattga aaatgtcatg ctagccaaaa ccagaaaaat gcatatcaat tcaagcttca
    16021 tgatgttgtg agattctcgt cagttagccg gcttcgagtt gcttgatgat tttttgagtt
    16081 gtgtagtttg aaattgactc aacaacaatt gagggtcacg taacattcag caaatttatt
    16141 ttattgacca atggccaaaa taagtttgct gaatgattga ccgaagtgaa ctcatttaat
    16201 agccccagtt tacaattcaa gtgcaacacc ctgacgacta gaccataaag gccatgaaga
    16261 cctattcttg ttagtgcta
//
