LOCUS       gnlProkkaKDOOIGDA_4    12142 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|KDOOIGDA_4.
ACCESSION   gnlProkkaKDOOIGDA_4
VERSION     gnlProkkaKDOOIGDA_4
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2025-04-28 21:57:05
            Original ID  :: gnl|Prokka|KDOOIGDA_4
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 39384
            Orig. end    :: 51526
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12142
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:7142]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..7142
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..12142
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..12142
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             636..2186
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1249:carbamoyl phosphate synthase small subunit
                     (Score: 384.9; E-value: 5.4e-117)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg4_40"
                     /transl_table=11
                     /translation="MTTMTKLVNEMILVLDFGSQYNQLITRRIREFGVYSELHPHTLTA
                     EEIKEMNPKGIILSGGPNSVYDEGSFRCDEKIFELDIPVLGICYGMQLMTHYLGGKVEA
                     ASQREYGKANIQIQGTPDLFKDLPEEQVVWMSHGDLVVQVPEGFTVDATSHHCPNSAMS
                     KKDKKWYGVQFHPEVRHSEYGNDLLKNFVFGPCECKGEWSMENFIEIEMQKIRETVGDK
                     QVLCALSGGVDSSVVAVLIHKAIGDQLTCIFVDHGLLRKGEAEGVMKTFSEGFNMNVIK
                     VDAKDRFLNKLKGVSDPEQKRKIIGNEFIYVFDDEADRLKGIDYLAQGTLYTDIIESGT
                     ATAQTIKSHHNVGGLPEDMQFELIEPLNTLFKDEVRALGTELGIPDDIVWRQPFPGPGL
                     GIRVLGEVTEEKLEIVRESDAILREEVANHGLERDIWQYFTVLPDIRSVGVMGDARTYD
                     YTIGIRAVTSIDGMTSDWARIPWDVLEVISTRIVNEVKHINRVVYDITSKPPATIEWE"
     CDS             2550..3812
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Dala_Dala_lig_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1063:argininosuccinate lyase/adenylosuccinate lyase
                     (Score: 75.6; E-value: 6.8e-23)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg4_41"
                     /sec_met_domain="ATP-grasp_3 (E-value: 2.1e-13, bitscore:
                     44.8, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="ATP-grasp (E-value: 7.7e-09, bitscore:
                     29.4, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Dala_Dala_lig_C (E-value: 1.3e-07,
                     bitscore: 25.4, seeds: 12, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEKHILFFNATYIKKISTLETAKNLGLTVSVVGPELPEWSRPFVD
                     HYISANTYQIDETIAVLKETAKENPFDGVITFWDRDVVPVAVTARELNLKGSPVEAAER
                     ARNKWKMRQCLNRAQVPHPKYCKFTNWTELYHASIDMEYPLIVKPVGASASKGVFRISK
                     PEDLNRAYQQLLNAAVPENDKMFSFYQNEYIVEEFMNGQEVSIEGVISDGVIHFAGVTE
                     KWTDQYFEEYQHAFPARLPEAVERELFHITSEGIKALELNNCGFHAEVMITEKGCKIIE
                     INGRLGGDFITTHLVPLAKGINITRANLLAVLGETISFEASKRRAACVRFLIADRAGVI
                     EKWEGVESIKEMPGVVEFVLEKQPGDHVGLPPEKFHDSRIAYVITEAEDTEKAIEYAEN
                     ALSEVRCFINGEEKTVPDRDS"
     CDS             3775..4986
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RimK"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Dala_Dala_lig_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg4_42"
                     /sec_met_domain="ATP-grasp_3 (E-value: 1.7e-16, bitscore:
                     54.8, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="RimK (E-value: 1e-06, bitscore: 22.6,
                     seeds: 4, tool: rule-based-clusters)"
                     /sec_met_domain="Dala_Dala_lig_C (E-value: 8e-11, bitscore:
                     35.9, seeds: 12, tool: rule-based-clusters)"
                     /sec_met_domain="ATP-grasp (E-value: 5.4e-10, bitscore:
                     33.2, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MERKRLFLIGIPETHIEKAVTRAKQLGFDVLLGDTEASLKKYEHL
                     IKEADQKIALDYTNHENLFSVAKEIHDKEPLDAIFTFKEAGLFNVSKLQQAFHLKGNPP
                     SVVQACLDKYTTRRLLKKAGLNSPDFGLCRSVEDVYDFWNTSQHPIILKPRSQQGSIGV
                     IKVEKKEDIEACFKECSKHDEEKSVLAEEFIEGQEISIEAVVCQGKVDIFGVTEKLLYP
                     GTFVESGHISPYKHKEKHQDLYKNLVKEVVHAMGIVFGPLHIEGYHTNKGFVVGEVHTR
                     YGGDNIVTITEIAMKCDMHTPIFAELAGIPYQPERKHAQSEVCAVRFLETNQGVVRAIK
                     GISDLKMMGNVVDFHVNCSVGDRIRPIKNSYDRAGWMIVKGKNEREVNHALHDAIDKIK
                     IIIR"
     CDS             5001..5885
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) phosphonates-like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 264.5;
                     E-value: 1.9e-80)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg4_43"
                     /sec_met_domain="phosphonates (E-value: 2.8e-109, bitscore:
                     358.7, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates-like (E-value: 3.1e-127,
                     bitscore: 417.3, seeds: 13, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 1.9e-68, bitscore:
                     224.6, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNRKSSIFRDALDSKGLVKVAGAHDGLSAKLAEKNGFNAVWASG
                     LGISAVQTVPDASILTMTEFLEAAVIMNESCNLPVIADCDSGYGNIHNVTRMIKKYEAA
                     GIAGVCIEDKVYPKLNSFDDRQQILVSTEEFCAKIRAAKMAQQNDDFVLIARVEALIAK
                     LGQEEAYTRAKAYVHAGADAILIHSKEQSPDEIIEFVNNWDVDAPLVVVPTKYPTLSME
                     QLEKLGVKVSIYANQALRASVKAINDTFESIINNKSSLQIENDIVSVNEIFDIQDVPGM
                     KQLERLIHRQPAN"
     CDS             5943..7142
                     /NRPS_PKS="Domain: Aminotran_1_2 (32-388). E-value:
                     5.3e-70. Score: 228.2. Matches aSDomain:
                     nrpspksdomains_ctg4_44_Aminotran_1_2.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_1_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1019:aminotransferase (Score: 288.3; E-value:
                     1.5e-87)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg4_44"
                     /sec_met_domain="Aminotran_1_2 (E-value: 2.9e-69, bitscore:
                     228.0, seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 5.4e-11,
                     bitscore: 36.4, seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKRLSDRVMNIKPSATMSLNAKTKIMVKEGKDIINMSVGEPDLH
                     PPLTASYAGIQAIVKGKTGYTPAAGLIELRESIVRYLLNERGLEYKPNQIIASAGGKQP
                     LYNVFQAICDQDDEVILPSPYWVSYPEQIKLSGAVPVIVSCDETTNFKITPEKLAEVIT
                     PKTKAVVITSPNNPTGSVYSENELKALGNVLKDYSGIFIISDEIYDQFVYEGKHISLPL
                     IFPELLNRTIITNGFSKVFAMTGWRLGYIAAPSDIAEAIASFQSHATGSPSTISQYAGI
                     SALNGFDKSMVEEYKKRRDILVDGLNQIEGIQCTKPNGAFYAFPNVSQFFGTMFEDQQI
                     IDAETFCHLLLEKQHVSAVPGTAFGEPKNIRLNFAIPKDLITEALKRINNFTTQLAVKV
                     "
     aSDomain        6039..7106
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg4_44_Aminotran_1_2.1"
                     /evalue="5.30E-70"
                     /label="ctg4_44_Aminotran_1_2.1"
                     /locus_tag="ctg4_44"
                     /protein_end="388"
                     /protein_start="32"
                     /score="228.2"
                     /tool="antismash"
                     /translation="DIINMSVGEPDLHPPLTASYAGIQAIVKGKTGYTPAAGLIELRES
                     IVRYLLNERGLEYKPNQIIASAGGKQPLYNVFQAICDQDDEVILPSPYWVSYPEQIKLS
                     GAVPVIVSCDETTNFKITPEKLAEVITPKTKAVVITSPNNPTGSVYSENELKALGNVLK
                     DYSGIFIISDEIYDQFVYEGKHISLPLIFPELLNRTIITNGFSKVFAMTGWRLGYIAAP
                     SDIAEAIASFQSHATGSPSTISQYAGISALNGFDKSMVEEYKKRRDILVDGLNQIEGIQ
                     CTKPNGAFYAFPNVSQFFGTMFEDQQIIDAETFCHLLLEKQHVSAVPGTAFGEPKNIRL
                     NFAIPKDLITEALKRI"
     CDS             7207..8439
                     /gene_functions="transport (smcogs) SMCOG1202:major
                     facilitator transporter (Score: 254.7; E-value: 1.8e-77)"
                     /gene_kind="transport"
                     /locus_tag="ctg4_45"
                     /transl_table=11
                     /translation="MKGIRLRIHPVGWNIILGTLFSRMSVSMSIPFLSIYLTQVKGVSP
                     ALTGIIVSVSSLAGIVMSFYGGYLSDLFGRKIVMITSVFCWALVFVSFMFADSVLAFFV
                     INALNGLCQSIFEPASRALLSDISKEENRLKMFNLRYTAINIGVVFGPLLGLRLGAAKT
                     ALPFLFAGFTYFLYGLSLVFSFRKFKLDENNRKENKTTIATAFNVTRKDKVFLITLLGV
                     ILSISGYAHFSTTLPQYFAAKIEDGVTIFSWLLALNAIVVLIVQYPIVNIMKKFPPIHS
                     IILGNALISFSLLFFSLSSNPFIWGSIVVFFTIGEVLIFSMVDMLVDEIAKPGFKGTYF
                     GAAGFNRLGNVIGPWLGGILLSFFGVNGSFYMFLIIFITTASGIPVLFLAKKHLDKSGH
                     SKVDVTESHRS"
     CDS             8758..9291
                     /gene_functions="regulatory (smcogs) SMCOG1032:RNA
                     polymerase, sigma-24 subunit, ECF subfamily (Score: 107.1;
                     E-value: 1.3e-32)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg4_46"
                     /transl_table=11
                     /translation="MKEERLIKKAKKGDAAAFEKLITAHQDTLYKTAYLYLHHKEDTLD
                     AVQETAYKAFLHIAQLREPKYFKTWLIRILLHTIFAMRKKHGDVIPFEPQHDTRAENKN
                     IEEYIDLRNALETLDEHIQLTIQLYYFQDFSIAMIAEQTGMAEGTVKTHLHRARKALKQ
                     ELEKEDKHIWKSIK"
     CDS             9273..10715
                     /locus_tag="ctg4_47"
                     /transl_table=11
                     /translation="MEKHQMKQLYQDIDVPKAELKNVIHSAAVRAGKEGAVRRRWGRKL
                     INGLAVAAALFILYLSSGLFMPSVNTAMGNIPVAGQIYSLFQDKAGSALFKSNLVTKLN
                     EKAESRGITVTVKSVYYDSGQLVYNFTVDNLKSDEESISFQVDYKDPWNMLAEDYDNSN
                     MKKMKDGQYAGQLRLFTDGSKLKDGDKLPLVITQIKDIPGNWRFTLPIKKQKSVSLEGT
                     KAVNVNHGLYRFFDIRAENGTTGSALLYSIDFYDAAKNDAISIYEATDDAGNHYEMTAS
                     NIELGGRKNLPGGGKRIRGQTQFSKPIDPKAKTLFITGDIKTESEPGEIVPLKTKLPVS
                     YKTKHHHVGITIKKIKQQGRRVIVDYQFTGINYSKADEDQLINVGESIGLGNTKKMKTW
                     PSLNEYEKGYYLKGNKAKVTNLKTGEMESVFELDDSSNKDYSLRDFSFDSYALYVNQTV
                     MNLLADDKGITFAVPVRPADGK"
ORIGIN
        1 ggaactcgga tgcaccgtct gacaagcagc gtcaggaatc aaagccggaa aaagaggaaa
       61 agccgaaaaa gcgggatcac agcgcggcac cgcagcctgt gatccgcaac aaaaccgcgg
      121 cacagctatg gccgtatgca gccatcgtca ttgtgatttc agccgcggcg gcactcgcct
      181 ggctgctccg ggcgcgctgg attccgcacg ttacagcagc cagattgaag cggcgaacgg
      241 atgaagacgt ctttttcgac gcatatgccg cgctgctccg ccagctgaaa cgaaaagggt
      301 tcagcaggag agacggagaa acgctccgtg attttgccgc gagggttgac gaggcgcacc
      361 atacaaacga catgtccgag ctgacgctgc gctatgagcg tgcattatac cgcagcgata
      421 atgccgcaaa gctttggaat gaatcgggac agttgtggga aaatataatt aaaagaagat
      481 agtcttgacc gcatatcgtc ctgttgttag aataaatgaa tgttaaatgg gagcccggga
      541 gcgttaaaaa gccgggcttc cggacaagtc ttgccgacag agggctgaac gtgtgtcctc
      601 cgttttttct gtgtcaaaaa cttagaggag attaggtgac aaccatgacg aagttagtga
      661 atgaaatgat tcttgttctt gatttcggca gtcagtataa ccagctgatt acccgccgga
      721 tccgtgaatt tggcgtatat agcgagctgc atccccatac gttgacagct gaggaaatca
      781 aagaaatgaa tccaaaagga attatccttt caggcggacc aaacagtgta tatgatgaag
      841 ggtctttccg ctgtgatgaa aaaatctttg aacttgatat tcctgtattg ggcatctgct
      901 acggcatgca gctgatgact cattacctcg gagggaaagt cgaggcggca agccagcgcg
      961 aatacggaaa agcgaacatt cagattcaag gaactcctga cttgttcaaa gatcttccgg
     1021 aagaacaagt tgtctggatg agccacggcg acttagtcgt acaagtgccg gaagggttta
     1081 cggtagacgc gacaagccat cactgcccga actcggcgat gagcaaaaaa gacaaaaaat
     1141 ggtacggtgt tcagttccat ccggaagtcc gtcattcaga atacggaaat gaccttctga
     1201 aaaactttgt cttcgggcct tgtgaatgta aaggcgaatg gtcaatggaa aactttatcg
     1261 aaatcgaaat gcaaaaaatc cgcgaaacag tcggagacaa acaagtgctt tgcgctttga
     1321 gcggcggagt cgattcttct gtcgtagccg ttttgattca taaagcgatc ggcgaccagc
     1381 tgacttgtat tttcgtagat cacggccttc tccgcaaagg cgaagcggaa ggcgtcatga
     1441 aaacgttcag cgaaggcttt aatatgaatg tcattaaagt tgatgcgaaa gacagattct
     1501 taaacaagct gaaaggtgtt tctgatcctg agcaaaaacg caaaatcatc ggcaacgaat
     1561 tcatttacgt atttgatgat gaagcggaca ggctgaaagg aatcgactac cttgcgcaag
     1621 gaacgcttta cacagacatt attgaaagcg gaacggcaac tgcgcaaacg atcaaatcgc
     1681 accacaatgt cggcggactt cctgaagata tgcaatttga actgatcgaa ccgctgaaca
     1741 ctcttttcaa agatgaagtg cgcgcgctcg gcacagagct cggcatcccg gatgatatcg
     1801 tatggcgtca gccgttcccg ggccctggac ttggcatccg cgtactcggc gaagtaacgg
     1861 aagaaaaact tgagatcgtt cgtgaatcag acgcgattct gcgtgaagaa gtggcgaacc
     1921 acggccttga gcgcgacatc tggcagtact tcacggttct tcctgacatc cgcagcgtcg
     1981 gcgtcatggg agatgcgaga acgtatgatt acacaatcgg tatccgtgcc gtaacatcaa
     2041 ttgacggcat gacatctgac tgggcgcgta tcccttggga tgtgcttgaa gtgatttcga
     2101 cacggatcgt caatgaagtg aaacacatca acagagtggt gtacgatatt acttctaagc
     2161 cgcctgcaac aattgagtgg gaataatgag aaaagcctca aatcttttat ttataaagat
     2221 ttgaggcttt tttaatttac atggttctag gaataatagg ccttttatca ttaacaccgg
     2281 agaagatgtg cagcagtttt ttatatattc gagtttttta atcagttgta ttcctaatat
     2341 tctccctata atttcatttt ttctaataaa actgaattca taaaatattc atttaataac
     2401 aaataatgta tgttattatg aatatataca aataaaacat atgatggttt gtgttttcca
     2461 aggggttttt ttatcttctg cattcagttc tttagaaacg cagaaggttt ctaatttgca
     2521 gaaaaaaatg ttgaaagagg ctcggaagga tggaaaaaca tattttattt tttaatgcta
     2581 cttatattaa aaaaatttct actttggaga ctgctaaaaa tttgggcttg acggtttctg
     2641 ttgtcggccc tgaactgcct gaatggtcgc ggccattcgt tgaccattac atttccgcaa
     2701 atacttatca gattgatgag actatagctg ttctgaagga aactgccaaa gaaaatcctt
     2761 ttgatggagt cattacattc tgggatagag atgtggttcc ggtggcggta actgcccgag
     2821 aacttaactt aaagggcagt ccggtggaag cggcagaacg ggctcgaaac aaatggaaga
     2881 tgcgtcaatg tttgaaccgc gcacaagttc ctcatccaaa atattgcaaa tttacaaatt
     2941 ggaccgaatt atatcatgca agcattgata tggaataccc attgatcgtt aaacctgtgg
     3001 gtgcttctgc cagtaaaggc gtattccgaa tatcaaagcc tgaagattta aaccgcgcat
     3061 atcagcagct gttaaacgct gcggtgccgg aaaacgataa aatgttttct ttttatcaaa
     3121 acgagtatat tgttgaagag tttatgaacg gacaagaagt cagcattgag ggagtgattt
     3181 ccgacggagt cattcacttt gcaggtgtta ctgaaaaatg gacggatcag tatttcgaag
     3241 aataccagca tgcatttccc gccaggctgc cggaggctgt ggaacgtgaa ttattccaca
     3301 tcaccagtga agggataaaa gctttggagc tgaacaattg tggttttcat gccgaggtca
     3361 tgatcacaga gaaagggtgc aagattatcg agatcaacgg tcgtctgggc ggcgatttta
     3421 ttactaccca tttggttcct ctagccaaag gtataaatat aacgcgcgca aacctattgg
     3481 ctgtattagg agaaacaata agctttgaag cttcgaaaag aagagctgcc tgcgtcaggt
     3541 ttttaattgc agaccgtgct ggtgtgatag aaaagtggga aggtgtcgaa tcgatcaaag
     3601 aaatgcccgg ggtcgttgaa tttgttttag aaaagcagcc gggcgatcat gttggcctgc
     3661 cgcctgaaaa gtttcatgat tcccggattg cttatgtcat cacagaagcc gaagatacag
     3721 aaaaagcgat cgaatatgct gaaaatgctt tatctgaagt gaggtgtttc atcaatggag
     3781 aggaaaagac tgttcctgat cgggattcct gaaacgcata ttgagaaggc cgttacgagg
     3841 gcaaaacaac ttggttttga cgtcttatta ggagatacag aagcttcatt aaaaaaatat
     3901 gagcatttaa taaaggaagc tgaccaaaaa atcgcattag attataccaa tcatgagaat
     3961 ctattctcag tcgctaaaga aatccatgac aaagagcctt tagatgccat atttactttc
     4021 aaagaagccg gcttattcaa tgtatccaaa cttcagcagg catttcattt aaaaggaaat
     4081 cctccgtctg tggtgcaagc atgccttgat aaatatacaa cgcgccggct tttaaaaaag
     4141 gcaggactaa actctcccga ttttggattg tgcaggagcg tggaagacgt atacgatttt
     4201 tggaatacat ctcagcatcc tatcatttta aagccgagat ctcagcaagg cagtataggc
     4261 gtcataaaag ttgagaaaaa agaggacatt gaggcgtgtt ttaaagagtg ttcaaaacat
     4321 gacgaggaga agtcagtatt agccgaagaa tttatagaag ggcaggaaat ttcaatagaa
     4381 gccgttgtct gccaaggcaa ggtcgacata tttggtgtga ccgaaaagct gctatacccc
     4441 gggacttttg tagaatccgg gcatatatcg ccgtataaac ataaagaaaa acatcaggat
     4501 ttgtataaga atctggtcaa ggaagttgtt catgccatgg ggatcgtatt tgggcccttg
     4561 catattgaag ggtatcacac aaataaagga tttgtggttg gcgaggtaca cacccgctat
     4621 ggcggagaca acatagtgac cattacagaa atcgccatga aatgtgatat gcatacacct
     4681 atttttgcgg aactggcggg catcccatat caaccggaaa ggaaacatgc tcaaagcgaa
     4741 gtatgcgccg ttcgtttttt agaaacgaac caaggggttg tacgcgcaat caaagggatc
     4801 agcgatctca aaatgatggg gaatgtagta gattttcatg taaattgcag tgtcggtgat
     4861 agaatcagac cgatcaaaaa cagctacgat agagcaggat ggatgattgt aaaggggaaa
     4921 aatgagcgag aagtcaatca cgcattacat gatgcgattg acaaaataaa aataatcatt
     4981 aggtgaaggg gagaatgatg gtgaaaaaca gaaaatcatc aatttttaga gatgctttag
     5041 acagtaaagg tttggtgaaa gttgcgggag ctcatgacgg tttaagcgcc aaattagcag
     5101 agaaaaacgg atttaatgcc gtatgggcaa gcggtttggg aatctcggct gtgcaaactg
     5161 tacctgatgc cagtatatta acgatgactg aatttcttga agccgccgtc attatgaatg
     5221 aatcatgcaa tttgccggtc atcgctgact gtgattccgg ctacgggaac attcacaatg
     5281 tcacccgcat gatcaaaaaa tacgaagctg ctggtattgc cggagtttgt attgaagata
     5341 aagtatatcc aaaattaaac tcatttgacg acagacaaca gatccttgtc agtactgaag
     5401 aattttgcgc aaaaattaga gccgcaaaga tggctcagca aaatgacgat tttgtattga
     5461 ttgcccgtgt cgaagcttta attgctaaat tgggtcaaga agaagcctat acaagagcaa
     5521 aagcttatgt tcatgctgga gcagatgcaa ttttaattca ttcaaaagaa caatcgcctg
     5581 atgaaattat tgagtttgtt aacaattggg acgtggatgc gccgttggtt gtggttccga
     5641 ctaaatatcc gacgctctca atggaacagc ttgagaaatt gggagtgaag gtttccatct
     5701 atgcgaatca ggcgttgcgc gcttctgtta aggctataaa tgatacattc gaaagcatta
     5761 taaataataa atcgtctttg cagattgaaa atgacatcgt gagcgttaat gagatatttg
     5821 acattcaaga cgttccgggg atgaagcaac tggagcgttt gatccataga cagccggcta
     5881 actgaggttt ttgtatcgtg ctattttaag aatggcccat aaagacattg gaggcgtttg
     5941 aattgaataa aagattatcc gatagagtca tgaatataaa accttcggcc actatgtcat
     6001 taaatgccaa aacgaagata atggtaaaag aaggaaaaga cattataaat atgagtgtcg
     6061 gagaaccgga tcttcatccg ccattaacag cctcatatgc aggaattcag gcaatagtga
     6121 aggggaaaac cgggtatacg ccggcagcag ggctgattga attaagagaa tccattgtgc
     6181 gatatctgct taacgaacga ggtttagaat ataaaccaaa ccaaataatt gcatctgccg
     6241 ggggaaaaca gccgctatat aatgtttttc aagcaatttg tgatcaagac gacgaagtta
     6301 tcctcccttc accttactgg gtatcttatc cggaacaaat caaactgtcg ggggcggttc
     6361 ctgttattgt aagctgtgat gaaactacaa attttaaaat cacacccgag aagcttgcag
     6421 aagtaattac ccctaagaca aaagctgttg ttatcacatc tcccaataat ccgacagggt
     6481 ccgtttattc agaaaatgaa ctgaaagctt taggaaatgt gttgaaagat tattctggaa
     6541 tttttatcat ttccgatgag atttatgatc agtttgtgta tgagggcaag catatcagtc
     6601 tgccgctcat ttttcccgaa ttgctgaatc ggaccatcat aacgaatgga ttttccaaag
     6661 tctttgcaat gactggatgg aggctcggct atatcgcagc cccatcggat atagccgaag
     6721 ccattgccag ctttcaaagc catgctacag gcagcccgtc aactatttct caatatgccg
     6781 gtatttctgc tttaaacggt tttgacaagt cgatggtcga agaatacaaa aaaagacgcg
     6841 atatattagt cgatggttta aatcaaattg agggcattca atgcaccaaa ccaaatggag
     6901 ccttttatgc gtttccgaac gtttcacaat ttttcggaac aatgtttgaa gatcaacaaa
     6961 taattgatgc ggagacattt tgtcatcttc tgttggaaaa acagcacgtg tcagctgttc
     7021 ccggcacagc attcggagag ccgaaaaaca ttcgtttgaa ttttgccatc ccaaaggatc
     7081 ttatcacaga ggctttgaaa agaattaata attttacaac tcagctggca gttaaggtat
     7141 aacagagcgc tgaaagctta aacgagcctc tttatatctg catctaatgt ttaggcaggt
     7201 ggttttttga aaggcatacg attaagaatt caccctgtgg gctggaatat cattttaggc
     7261 accttgttta gcagaatgtc agtctcgatg agcattccct tcctttctat ttatctaaca
     7321 caagtaaaag gtgtttctcc tgctttaacc ggcatcattg tttcagtaag ttcgctggct
     7381 gggattgtaa tgagctttta cggagggtat ttgtctgatc tttttggcag gaaaattgtg
     7441 atgataacgt ctgtattttg ttgggcgctt gtttttgtaa gttttatgtt tgcagatagt
     7501 gtactcgcat tttttgtcat caatgcgctt aacgggctgt gtcaatctat ctttgaaccg
     7561 gcgtcaagag cattattatc cgatataagc aaagaagaaa atcgtttgaa gatgtttaat
     7621 ttgcgatata ctgcgattaa tatcggcgta gttttcggtc ctcttttagg ccttagattg
     7681 ggagctgcca agacggctct cccatttctg ttcgcaggtt ttacatattt tctttatggt
     7741 ctatctctcg tattttcatt ccgaaaattt aaattagacg agaacaatcg aaaagaaaat
     7801 aaaacgacta ttgctacggc ttttaatgtg acaaggaaag acaaggtttt tcttatcaca
     7861 ttacttggag tgatattatc aatatccgga tatgcgcact tttctacaac attgccccaa
     7921 tattttgccg ccaaaataga ggacggggtg accatatttt catggctttt agctttgaat
     7981 gcaattgtcg tcttaatcgt tcaataccct attgtgaata tcatgaaaaa gttcccgccg
     8041 attcattcaa tcattctggg aaatgcttta attagtttca gtttattatt tttttcgcta
     8101 tcgtccaacc cattcatatg gggctctatc gtcgtgtttt tcacaatagg ggaagttttg
     8161 attttttcga tggttgatat gctggtggat gaaattgcaa aaccaggctt caaagggaca
     8221 tactttggag cagcaggctt taaccgttta ggaaatgtaa tcggtccttg gctgggaggg
     8281 attcttcttt ccttttttgg tgtaaacggg tccttctata tgtttttgat catttttata
     8341 acgacagcct cgggaattcc ggttttattt ttggcaaaaa aacatcttga taagagcgga
     8401 cattcaaaag ttgatgtaac agaatctcat aggagttaaa tgttttaaca caatgaagaa
     8461 ttaatggcaa agtctttgaa cctcaaaggt ttaaaggctt ttttcttttc agcagcgccc
     8521 catcagaatg ggaaacaaga gtgtttatat ttttggggag aggaatacag actgaacggc
     8581 gaacaaagaa ggtattaatc taagggactg accccataag atgagacaaa taaaaaacac
     8641 cttcaagttt gaaaacggat cgttgttatc cgaaattaga ctttgaggcg tttttttttc
     8701 atctttttga aaccgttttg ccttgattca tatctaacag cataggaggt ggataaggtg
     8761 aaggaagaac gattgatcaa aaaggcgaaa aaaggtgatg ccgcagcctt tgaaaaactg
     8821 atcacagcac accaggatac tttatataaa acagcttatc tctatttgca tcacaaggaa
     8881 gatacactgg acgctgttca ggagacggct tacaaggctt ttcttcatat cgcgcagctg
     8941 agggagccga aatattttaa aacgtggctg atccggattt tgcttcatac gatttttgcg
     9001 atgaggaaaa agcacggaga cgtcatcccg tttgagccgc agcatgatac gcgcgcggag
     9061 aataagaaca ttgaagaata catagatctt cggaatgccc tggaaacgct tgacgaacat
     9121 atacagctga ccattcagct ttattatttt caagatttct cgattgctat gatcgctgaa
     9181 cagaccggta tggcggaagg cactgtaaaa acgcatctcc acagggcgag aaaagcattg
     9241 aagcaggagc tggaaaagga ggataaacat atatggaaaa gcatcaaatg aagcaattgt
     9301 atcaggacat tgacgtgccg aaagctgaat tgaaaaatgt gatacacagc gccgctgtcc
     9361 gtgccggaaa agaaggcgcc gtcagacgga gatggggaag aaaactgata aacggactcg
     9421 cggttgctgc tgctttgttt attctgtatt tgtcctcagg cttattcatg ccctccgtta
     9481 atacggctat gggaaacatt cctgttgccg gacaaattta cagtctgttt caggataagg
     9541 caggttctgc gctgtttaaa agcaatttgg tgacaaaact gaatgagaaa gcggaatcac
     9601 gcggaatcac ggtgacagtg aaaagtgtgt attacgacag cggacagctc gtttacaatt
     9661 ttaccgttga caatttgaaa tcagatgagg agagcatctc ttttcaagtt gattataaag
     9721 atccatggaa tatgttagca gaggattatg acaacagtaa tatgaaaaaa atgaaagacg
     9781 ggcagtacgc gggacagctt cgcctgttca cggacggctc aaagctgaaa gacggtgata
     9841 agcttccgct tgtcattaca caaatcaagg atatcccggg aaactggcgc tttacactcc
     9901 ctattaaaaa acaaaagtcc gtttctcttg aaggaacgaa agctgtgaat gtaaatcacg
     9961 gattataccg ctttttcgat atccgggcgg aaaacggaac gacgggatcg gctctcctgt
    10021 attctatcga cttctatgat gcagccaaaa atgatgccat ctcgatttac gaggcaacgg
    10081 atgatgccgg aaaccattat gaaatgacgg cgtcgaatat tgaacttggc ggcagaaaga
    10141 atcttcccgg cggcgggaaa agaatacgcg gccaaactca attcagcaaa ccgatagacc
    10201 cgaaagcgaa aacacttttc ataacgggcg atataaaaac agaatcagag ccgggagaaa
    10261 tcgtgcctct gaaaacaaaa ctgcccgtca gttataaaac gaaacatcat catgtcggca
    10321 tcaccatcaa aaagatcaaa cagcaaggca gacgggtgat cgtcgattat caattcacag
    10381 gaattaatta cagcaaagcg gatgaagatc agctgatcaa tgtcggtgag tcaatcggtc
    10441 tcggcaatac gaaaaaaatg aaaacctggc catcgcttaa tgagtatgaa aaaggctatt
    10501 atctgaaagg gaataaggcg aaagtcacga accttaaaac gggtgaaatg gaatccgttt
    10561 ttgaattgga tgattcatcc aataaagact attcgttgcg cgatttctca ttcgattcat
    10621 acgctttgta cgtcaatcaa acggttatga acttgctggc ggatgataag gggatcacat
    10681 tcgcggtgcc ggttcggcct gcggacggaa aatgatgtct ggaaggcggc ttttgccgtc
    10741 ttccattttt ggtcaattaa cgaataaacc aaattttttt aacgggattg ttcgtttttt
    10801 ttattgagtt ttcaaaattg aattgataca atagactcag aaatcaaata tgcagatatc
    10861 gtataatggc ggggatatgg cccgcaagtt tctaccaagc taccgtaaat ggcttgacta
    10921 cggatcaatc tcaatcgttt gatataaata atccattctt atttattcag actgaacgta
    10981 tgtagtcaag cgtcccaaat gtatttgggg cgttttttat ttggcggata acgggcagaa
    11041 taaatgggag agaatgaagg aggcaattgg cttgaagcaa ttttttcagt ttgatgagct
    11101 ggggacaagc tatcgtaatg aaatcatcgg cggtttaacg acctttttgt caatggcgta
    11161 cattctgttc gtcaatccgc tgacattgtc tttaaacggt gtgaagggat ttccggaagc
    11221 attaaaaatt gatcagggcg cggtgttcac cgctacagcc ttggcgtctg cggccggctg
    11281 tattttaatg gggctcattg caaagtatcc gatcgcgatt gcgccgggta tgggattaaa
    11341 tgcgtttttt gctttctctg tcgtcctcgg catggggatt tcatggcagg ctgcgctttc
    11401 cggcgtcttg atttccggaa ttatcttcgt ggcgctttcg ctgacgggac tgcgggaaaa
    11461 aatcattaat gcgattccgc ctgagctgaa attggcggtc ggcgcgggta tcggtttgtt
    11521 tatcacattt gtcggtttgc agggttcggg cattattgaa gcgaactcat cgactttggt
    11581 gtctatcggc aatattcaca gcggccctgt gctgctgacg gttttcggtg ttattgtgac
    11641 ggtcattctg atggtgcttc gcgtaaacgg cggcgtattt atcggaatgc ttctgacggc
    11701 ggttgccggc atggtctgcg gactgattcc ggttccgacg cacattgtcg gcagcgtgcc
    11761 gagtcttgcg ccgactttcg gacaggcgtg gatgcatctt ccggatatct tctccgtaca
    11821 aatgctgatt gtcattttaa ctttcttgtt cgtcgggttt ttcgatacgg ccggaacgct
    11881 ggtggctgta gcgacacagg ccgggctgat gaaggaaaac aaacttccgc gtgcgggaag
    11941 agcgcttctg gcagattcga catcaatcgt tatcggagcc gtactcggta cgtctacaac
    12001 gacttcttat gttgaatcca gctcaggcgt tgcggcgggg gcgcgctccg gcttcgcggc
    12061 tgttgtgacg ggcattctct ttttgctggc gatgtttttc tcgccgcttc tgtcagttgt
    12121 caccacgaat gtgacggctc cg
//
