LOCUS       gnlProkkaMCGBOIFP_4    12142 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|MCGBOIFP_4.
ACCESSION   gnlProkkaMCGBOIFP_4
VERSION     gnlProkkaMCGBOIFP_4
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2025-04-28 22:35:43
            Original ID  :: gnl|Prokka|MCGBOIFP_4
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 216266
            Orig. end    :: 228408
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12142
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:7142]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..7142
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..12142
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..12142
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             complement(1428..2870)
                     /locus_tag="ctg4_213"
                     /transl_table=11
                     /translation="MEKHQMKQLYQDIDVPKAELKNVIHSAAVRAGKEGAVRRRWGRKL
                     INGLAVAAALFILYLSSGLFMPSVNTAMGNIPVAGQIYSLFQDKAGSALFKSNLVTKLN
                     EKAESRGITVTVKSVYYDSGQLVYNFTVDNLKSDEESISFQVDYKDPWNMLAEDYDNSD
                     MKKMKDGQYAGQLRLFTDGSKLKDGDKLPLVITQIKDIPGNWRFTLPIKKQKSVSLEGT
                     KAVNVNHGLYRFFDIRAENGTTGSALLYSIDFYDAAKNDAISIYEATDDAGNHYEMTAS
                     NIELGGRKNLPGGGKRIRGQTQFSKPIDPKAKTLFITGDIKTESEPGEIVPLKTKLPVS
                     YKTKHHHVGITIKKIKQQGRRVIVDYQFTGINYSKADEDQLINVGESIGLGNTKKMKTW
                     PSLNEYEKGYYLKGNKAKVTNLKTGEMESVFELDDSSNKDYSLRDFSFDSYALYVNQTV
                     MNLLADDKGITFAVPVRSADGK"
     CDS             complement(2852..3385)
                     /gene_functions="regulatory (smcogs) SMCOG1032:RNA
                     polymerase, sigma-24 subunit, ECF subfamily (Score: 106.1;
                     E-value: 2.6e-32)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg4_214"
                     /transl_table=11
                     /translation="MKEERLIKKAKKGDAAAFEKLITAHQETLYKTAYLYLHHKEDTLD
                     AVQETAYKAFLHIAQLKEPKYFKTWLIRILLHTIFAMRKKHGDVIPFEPQHDTRAENKN
                     IEEYIDLRNALETLDEHIQLTIQLYYFQDFSIAMIAEQTGMAEGTVKTHLHRARKALKQ
                     ELEKEDKHIWKSIK"
     CDS             complement(3704..4936)
                     /gene_functions="transport (smcogs) SMCOG1202:major
                     facilitator transporter (Score: 254.7; E-value: 1.8e-77)"
                     /gene_kind="transport"
                     /locus_tag="ctg4_215"
                     /transl_table=11
                     /translation="MKGIRLRIHPVGWNIILGTLFSRMSVSMSIPFLSIYLTQVKGVSP
                     ALTGIIVSVSSLAGIVMSFYGGYLSDLFGRKIVMITSVFCWALVFVSFMFADSVLAFFV
                     INALNGLCQSIFEPASRALLSDISKEENRLKMFNLRYTAINIGVVFGPLLGLRLGAAKT
                     ALPFLFAGFTYFLYGLSLVFSFRKFKLDENNRKENKTTIATAFNVTRKDKVFLITLLGV
                     ILSISGYAHFSTTLPQYFAAKIEDGVTIFSWLLALNAIVVLIVQYPIVNIMKKFPPIHS
                     IILGNALISFSLLFFSLSSNPFIWGSIVVFFTIGEVLIFSMVDMLVDEIAKPGFKGTYF
                     GAAGFNRLGNVIGPWLGGILLSFFGVNGSFYMFLIIFITTASGIPVLFLAKKHLDKSGH
                     SKVDVTESHRS"
     CDS             complement(5001..6200)
                     /NRPS_PKS="Domain: Aminotran_1_2 (32-388). E-value:
                     5.6e-70. Score: 228.1. Matches aSDomain:
                     nrpspksdomains_ctg4_216_Aminotran_1_2.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_1_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1019:aminotransferase (Score: 288; E-value: 1.9e-87)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg4_216"
                     /sec_met_domain="Aminotran_1_2 (E-value: 2.9e-69, bitscore:
                     227.9, seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 6.7e-11,
                     bitscore: 36.0, seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKRLSDRVMNIKPSATMSLNAKTKIMVKEGKDIINMSVGEPDLH
                     PPLTASYAGIQAIVKGKTGYTPAAGLIELRESIVRYLLNERGLEYKPNQIIASAGGKQP
                     LYNVFQAICDQDDEVILPSPYWVSYPEQIKLSGAVPVIVSCDETTNFKITPEKLAEVIT
                     PKTKAVVITSPNNPTGSVYSENELKALGNVLKDYSEIFIISDEIYDQFVYEGKHISLPL
                     IFPELLNRTIITNGFSKVFAMTGWRLGYIAAPSDIAEAIASFQSHATGSPSTISQYAGI
                     SALNGFDKSMVEEYKKRRDILVDGLNQIEGIQCTKPNGAFYAFPNVSQFFGTMFEDQQI
                     IDAETFCHLLLEKQHVSAVPGTAFGEPNNIRLNFAIPKDLITEALKRINNFTTQLAVKV
                     "
     aSDomain        complement(5037..6104)
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg4_216_Aminotran_1_2.1"
                     /evalue="5.60E-70"
                     /label="ctg4_216_Aminotran_1_2.1"
                     /locus_tag="ctg4_216"
                     /protein_end="388"
                     /protein_start="32"
                     /score="228.1"
                     /tool="antismash"
                     /translation="DIINMSVGEPDLHPPLTASYAGIQAIVKGKTGYTPAAGLIELRES
                     IVRYLLNERGLEYKPNQIIASAGGKQPLYNVFQAICDQDDEVILPSPYWVSYPEQIKLS
                     GAVPVIVSCDETTNFKITPEKLAEVITPKTKAVVITSPNNPTGSVYSENELKALGNVLK
                     DYSEIFIISDEIYDQFVYEGKHISLPLIFPELLNRTIITNGFSKVFAMTGWRLGYIAAP
                     SDIAEAIASFQSHATGSPSTISQYAGISALNGFDKSMVEEYKKRRDILVDGLNQIEGIQ
                     CTKPNGAFYAFPNVSQFFGTMFEDQQIIDAETFCHLLLEKQHVSAVPGTAFGEPNNIRL
                     NFAIPKDLITEALKRI"
     CDS             complement(6258..7142)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) phosphonates-like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 264.8;
                     E-value: 1.5e-80)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg4_217"
                     /sec_met_domain="phosphonates (E-value: 3.4e-109, bitscore:
                     358.3, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates-like (E-value: 2.1e-127,
                     bitscore: 417.8, seeds: 13, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 1.4e-68, bitscore:
                     225.0, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNRKSSIFRDALNSKGLVKVAGAHDGLSAKLAEKNGFNAVWASG
                     LGISAVQTVPDASILTMTEFLEAAVIMNESCNLPVIADCDSGYGNIHNVTRMIKKYEAA
                     GIAGVCIEDKVYPKLNSFDDRQQILVSTEEFCAKIRAAKMAQQNDDFVLIARVEALIAK
                     LGQEEAYTRAKAYVHAGADAILIHSKEQSPDEIIEFVNNWDVDAPLVVVPTKYPTLSME
                     QLEKLGVKVSIYANQALRASVKAINDTFESIINNKSSLQIENDIVSVNEIFDIQDVPGM
                     KQLERLIHRQPAN"
     CDS             complement(7157..8368)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Dala_Dala_lig_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg4_218"
                     /sec_met_domain="ATP-grasp_3 (E-value: 3.9e-15, bitscore:
                     50.3, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="Dala_Dala_lig_C (E-value: 4.4e-10,
                     bitscore: 33.4, seeds: 12, tool: rule-based-clusters)"
                     /sec_met_domain="ATP-grasp (E-value: 8.6e-10, bitscore:
                     32.5, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MERKRLFLIGIPETHIEKAVTRAKQLGFDVLLGDTEASLKKYEHL
                     IKEADQKIALDYTNHENLFSVAKEIHDKEPLDAIFTFKEAGLFNVSKLQQAFHLKGNPP
                     SVVQACLDKYTTRRLLKKAGLNSPDFGLCRSVEDVYDFWNTSQHPIILKPRSQQGSIGV
                     IKVEKKEDIEACFKECSKHDEEKSVLAEEFIEGQEISIEADVCQGKVDIFGVTEKLLYP
                     GTFVESGHISPYKHKEKHQDLYKNLVKEVVHAMGIVFGPLHIEGYHTNKGFVVGEVHTR
                     YGGDNIVTITEIAMKCDMHTPIFAELAGIPYQPERKHAQSEVCAVRFLETNQGVVRAIK
                     GISDLKMMGNVVDFHVNCSVGDRIRPIKNSYDRAGWMIVKGKNEREVNHALHDAIDKIK
                     IIIR"
     CDS             complement(8331..9593)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Dala_Dala_lig_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1063:argininosuccinate lyase/adenylosuccinate lyase
                     (Score: 75.6; E-value: 6.8e-23)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg4_219"
                     /sec_met_domain="ATP-grasp_3 (E-value: 1.9e-13, bitscore:
                     44.8, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="ATP-grasp (E-value: 7.2e-09, bitscore:
                     29.4, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Dala_Dala_lig_C (E-value: 1.2e-07,
                     bitscore: 25.4, seeds: 12, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEKHILFFNATYIKKISTLETAKNLGLTVSVVGPELPEWSRPFVD
                     HYISANTYQIDETIAVLKETAKENPFDGVITFWDRDVVPVAVTARELNLKGSPVEAAER
                     ARNKWKMRQCLNRAQVPHPKYCKFTNWTELYHASIDMEYPLIVKPVGASASKGVFRISK
                     PEDLNRAYQQLLNAAVPENDKMFSFYQNEYIVEEFMNGQEVSIEGVISDGVIHFAGVTE
                     KWTDQYFEEYQHAFPARLPEAVERELFHITSEGIKALELNNCGFHAEVMITEKGCKIIE
                     INGRLGGDFITTHLVPLAKGINITRANLLAVLGETISFEASKRRAACVRFLIADRAGVI
                     EKWEGVESIKEMPGVVEFVLEKQPGDHVGLPPEKFHDSRIAYVITEAEDTEKAIEYAEN
                     ALSEVRCFINGEEKTVPDRDS"
     CDS             complement(9956..11506)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1249:carbamoyl phosphate synthase small subunit
                     (Score: 385.1; E-value: 4.6e-117)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg4_220"
                     /transl_table=11
                     /translation="MTTMTKLVNEMILVLDFGSQYNQLITRRIREFGVYSELHPHTLTA
                     EEIKEMNPKGIILSGGPNSVYDEGSFRCDEKIFELDIPVLGICYGMQLMTHYLGGKVEA
                     ASQREYGKASIQIQGTPDLFKDLPEEQVVWMSHGDLVVQVPEGFTVDATSHHCPNSAMS
                     KKDKKWYGVQFHPEVRHSEYGNDLLKNFVFGPCECKGEWSMENFIEIEMQKIRETVGDK
                     QVLCALSGGVDSSVVAVLIHKAIGDQLTCIFVDHGLLRKGEAEGVMKTFSEGFNMNVIK
                     VDAKDRFLNKLKGVSDPEQKRKIIGNEFIYVFDDEADRLKGIDYLAQGTLYTDIIESGT
                     ATAQTIKSHHNVGGLPEDMQFELIEPLNTLFKDEVRALGTELGIPDDIVWRQPFPGPGL
                     GIRVLGEVTEEKLEIVRESDAILREEVANHGLERDIWQYFTVLPDIRSVGVMGDARTYD
                     YTIGIRAVTSIDGMTSDWARIPWDVLEVISTRIVNEVKHINRVVYDITSKPPATIEWE"
ORIGIN
        1 cggagccgtc acattcgtgg tgacaactga cagaagcggc gagaaaaaca tcgccagcaa
       61 aaagagaatg cccgtcacaa cagccgcgaa gccggagcgc gcccccgccg caacgcctga
      121 gctggattca acataagaag tcgttgtaga cgtaccgagt acggctccga taacgattga
      181 tgtcgaatct gccagaagcg ctcttcccgc acgcggaagt ttgttttcct tcatcagccc
      241 ggcctgtgtc gctacagcca ccagcgttcc ggccgtatcg aaaaacccga cgaacaagaa
      301 agttaaaatg acaatcagca tttggacgga gaagatatcc ggaagatgca tccacgcctg
      361 tccgaaagtc ggcgcaagac tcggcacgct gccgacaatg tgcgtcggaa ccggaatcag
      421 tccgcagacc atgccggcaa ccgccgtcag aagcattccg ataaatacgc cgccgtttac
      481 gcgaagcacc atcagaatga ccgtcacaat aacaccgaaa accgtcagca gcacagggcc
      541 gctgtgaata ttgccgatag acaccaaagt cgatgagttc gcttcaataa tgcccgaacc
      601 ctgcaaaccg acaaatgtga taaacaaacc gatacccgcg ccgaccgcca atttcagctc
      661 aggcggaatc gcattaatga ttttttcccg cagtcccgtc agcgaaagcg ccacgaagat
      721 aattccggaa atcaagacgc cggaaagcgc agcctgccat gaaatcccca tgccgaggac
      781 gacagagaaa gcaaaaaacg catttaatcc catacccggc gcaatcgcga tcggatactt
      841 tgcaatgagc cccattaaaa tacagccggc cgcagacgcc aaggctgtag cggtgaacac
      901 cgcgccctga tcaattttta atgcttccgg aaatcccttc acaccgttta aagacaatgt
      961 cagcggattg acgaacagaa tgtacgccat tgacaaaaag gtcgttaaac cgccgatgat
     1021 ttcattacga tagcttgtcc ccagctcatc aaactgaaaa aattgcttca agccaattgc
     1081 ctccttcatt ctctcccatt tattctgccc gttatccgcc aaataaaaaa cgccccaaat
     1141 acatttggga cgcttgacta catacgttca gtctgaataa ataagaatgg attatttata
     1201 tcaaacgatt gagattgatc cgtagtcaag ccatttacgg tagcttggta gaaacttgcg
     1261 ggccatatcc ccgccattat acgatatctg catatttgat ttctgagtct attgtatcaa
     1321 ttcaattttg aaaactcaat aaaaaaaacg aacaatcccg ttaaaaaaat ttggtttatt
     1381 cgttaattga ccaaaaatgg aagacggcaa aagccgcctt ccagacatca ttttccgtcc
     1441 gcagaccgaa ccggcaccgc gaatgtgatc cccttatcat ccgccagcaa gttcataacc
     1501 gtttgattga cgtacaaagc gtatgaatcg aatgagaaat cgcgcaacga atagtcttta
     1561 ttggatgaat catccaattc aaaaacggat tccatttcac ccgttttaag gttcgtgact
     1621 ttcgccttat tccctttcag ataatagcct ttttcatact cattaagcga tggccaggtt
     1681 ttcatttttt tcgtattgcc gagaccgatt gactcaccga cattgatcag ctgatcttca
     1741 tccgctttgc tgtaattaat tcctgtgaat tgataatcga cgatcacccg tctgccttgc
     1801 tgtttgatct ttttgatggt gatgccgaca tgatgatgtt tcgttttata actgacgggc
     1861 agttttgttt tcagaggcac gatttctccc ggctctgatt ctgtttttat atcgcccgtt
     1921 atgaaaagtg ttttcgcttt cgggtctatc ggtttgctga attgagtttg gccgcgtatt
     1981 cttttcccgc cgccgggaag attctttctg ccgccaagtt caatattcga cgccgtcatt
     2041 tcataatggt ttccagcatc atccgttgcc tcgtaaatcg agatggcatc atttttggct
     2101 gcatcataga agtcgataga atacaggaga gccgatcccg tcgttccgtt ttccgccctg
     2161 atatcgaaaa agcggtataa tccgtgattt acattcacgg ctttcgttcc ttccagagaa
     2221 acggactttt gttttttaat aggtagtgta aagcgccagt ttccggggat atccttgatt
     2281 tgtgtaatga caagcggaag cttatcaccg tctttcagct ttgagccgtc cgtgaacagg
     2341 cgaagctgtc ccgcgtactg cccgtctttc atttttttca tatcactgtt gtcataatcc
     2401 tctgctaaca tattccatgg atctttataa tcaacttgaa aagagatgct ctcctcatct
     2461 gatttcaaat tgtcaacggt aaaattgtaa acgagctgtc cgctgtcgta atacacactt
     2521 ttcactgtca ccgtgattcc gcgtgattcc gctttctcat tcagttttgt caccaaattg
     2581 cttttaaaca gcgcagaacc tgccttatcc tgaaacagac tgtaaatttg tccggcaaca
     2641 ggaatgtttc ccatagccgt attaacggag ggcatgaata agcctgagga cagatacaga
     2701 ataaacaaag cagcagcaac cgcgagtccg tttatcagtt ttcttcccca tctccgtctg
     2761 acggcgcctt cttttccggc acggacagcg gcgctgtgta tcacattttt caattcagct
     2821 ttcggcacgt caatgtcctg atacaattgc ttcatttgat gcttttccat atatgtttat
     2881 cctccttttc cagctcctgc ttcaatgctt ttctcgccct gtgcagatgc gtttttacag
     2941 tgccttccgc cataccggtc tgttcagcga tcatagcaat cgagaaatct tgaaaataat
     3001 aaagctgaat ggtcagctgt atatgttcgt caagcgtttc cagggcattc cgaagatcta
     3061 tgtattcttc aatgttctta ttctccgcgc gcgtatcatg ctgcggctca aacgggatga
     3121 cgtcaccgtg ctttttcctc atcgcaaaaa ttgtatgaag caaaatccgg atcagccacg
     3181 ttttaaaata tttcggctcc ttcagttgcg cgatatgaag aaaagccttg taagccgttt
     3241 cctgaacagc gtccagtgta tcttccttgt gatgcaaata gagataagct gttttatata
     3301 aagtctcctg atgagctgtg atcagttttt caaaggctgc ggcatcacct tttttcgcct
     3361 ttttgatcaa tcgttcttcc ttcaccttat ccacctccta tgctgttaga tatgaatcaa
     3421 ggcaaaacgg tttcaaaaag atgaaaaaaa aacgcctcaa agtctaattt cggataacaa
     3481 cgatccgttt tcaaacttga aggtgttttt tatttgtctc atcttatggg gtcagtccct
     3541 tagattaata ccttctttgt tcgccgttca gtctgtattc ctctccccaa aaatataaac
     3601 actcttgttt cccattctga tggggcgctg ctgaaaagaa aaaagccttt aaacctttga
     3661 ggttcaaaga ctttgccatt aattcttcat tgtgttaaaa catttaactc ctatgagatt
     3721 ctgttacatc aacttttgaa tgtccgctct tatcaagatg tttttttgcc aaaaataaaa
     3781 ccggaattcc cgaggctgtc gttataaaaa tgatcaaaaa catatagaag gacccgttta
     3841 caccaaaaaa ggaaagaaga atccctccca gccaaggacc gattacattt cctaaacggt
     3901 taaagcctgc tgctccaaag tatgtccctt tgaagcctgg ttttgcaatt tcatccacca
     3961 gcatatcaac catcgaaaaa atcaaaactt cccctattgt gaaaaacacg acgatagagc
     4021 cccatatgaa tgggttggac gatagcgaaa aaaataataa actgaaacta attaaagcat
     4081 ttcccagaat gattgaatga atcggcggga actttttcat gatattcaca atagggtatt
     4141 gaacaattaa gacgacaatt gcattcaaag ctaaaagcca tgaaaatatg gtcaccccgt
     4201 cctctatttt ggcggcaaaa tattggggca atgttgtaga aaagtgcgca tatccggata
     4261 ttgataatat cactccaagt aatgtgataa gaaaaacctt gtctttcctt gtcacattaa
     4321 aagccgtagc aatagtcgtt ttattttctt ttcgattgtt ctcgtctaat ttaaattttc
     4381 ggaatgaaaa tacgagagat agaccataaa gaaaatatgt aaaacctgcg aacagaaatg
     4441 ggagagccgt cttggcagct cccaatctaa ggcctaaaag aggaccgaaa actacgccga
     4501 tattaatcgc agtataccgc aaattaaaca tcttcaaacg attttcttct ttgcttatat
     4561 cggataataa tgctcttgac gccggttcaa agatagattg acacagcccg ttaagcgcat
     4621 tgatgacaaa aaatgcgagt acactatctg caaacataaa acttacaaaa acaagcgccc
     4681 aacaaaatac agacgttatc atcacaattt tcctgccaaa aagatcagac aaataccctc
     4741 cgtaaaagct cattacaatc ccagccagcg aacttactga aacaatgatg ccggtcaaag
     4801 caggagaaac accttttact tgtgttaggt aaatagaaag gaagggaatg ctcatcgaga
     4861 ctgacattct gctaaacaag gtgcctaaaa tgatattcca gcccacaggg tgaattctta
     4921 atcgtatgcc tttcaaaaaa ccacctgcct aaacattaga tgcagatata aagaggctcg
     4981 tttaagcttt cagcgctctg ttatacctta actgccagct gagttgtaaa attattaatt
     5041 cttttcaaag cctctgtgat aagatccttt gggatggcaa aattcaaacg aatgttgttc
     5101 ggctctccga atgctgtgcc gggaacagct gacacgtgct gtttttccaa cagaagatga
     5161 caaaatgtct ccgcatcaat tatttgttga tcttcaaaca ttgttccgaa aaattgtgaa
     5221 acgttcggaa acgcataaaa ggctccattt ggtttggtgc attgaatgcc ctcaatttga
     5281 tttaaaccat cgactaatat atcgcgtctt tttttgtatt cttcgaccat cgacttgtca
     5341 aaaccgttta aagcagaaat accggcatat tgagaaatag ttgacgggct gcctgtagca
     5401 tggctttgaa agctggcaat ggcttcggct atatccgatg gggctgcgat atagccgagc
     5461 ctccatccag tcattgcaaa gactttggaa aatccattcg ttatgatggt ccgattcagc
     5521 aattcgggaa aaatgagcgg cagactgata tgcttgccct catacacaaa ctgatcataa
     5581 atttcgtcgg aaatgataaa aatttcagaa taatctttca acacatttcc taaagctttc
     5641 agttcatttt ctgaataaac ggaccctgtc ggattattgg gagatgtgat aacaacagct
     5701 tttgtcttag gggtaattac ttctgcaagc ttctcgggtg tgattttaaa atttgtagtt
     5761 tcatcacagc ttacaataac aggaaccgcc cccgacagtt tgatttgttc cggataagat
     5821 acccagtaag gtgaagggag gataacttcg tcgtcttgat cacaaattgc ttgaaaaaca
     5881 ttatatagcg gctgttttcc cccggcagat gcaattattt ggtttggttt atattctaaa
     5941 cctcgttcgt taagcagata tcgcacaatg gattctctta attcaatcag ccctgctgcc
     6001 ggcgtatacc cggttttccc cttcactatt gcctgaattc ctgcatatga ggctgttaat
     6061 ggcggatgaa gatccggttc tccgacactc atatttataa tgtcttttcc ttcttttacc
     6121 attatcttcg ttttggcatt taatgacata gtggccgaag gttttatatt catgactcta
     6181 tcggataatc ttttattcaa ttcaaacgcc tccaatgtct ttatgggcca ttcttaaaat
     6241 agcacgatac aaaaacctca gttagccggc tgtctatgga tcaaacgctc cagttgcttc
     6301 atccccggaa cgtcttgaat gtcaaatatc tcattaacgc tcacgatgtc attttcaatc
     6361 tgcaaagacg atttattatt tataatgctt tcgaatgtat catttatagc cttaacagaa
     6421 gcgcgcaacg cctgattcgc atagatggaa accttcactc ccaatttctc aagctgttcc
     6481 attgagagcg tcggatattt agtcggaacc acaaccaacg gcgcatccac gtcccaattg
     6541 ttaacaaact caataatttc atcaggcgat tgttcttttg aatgaattaa aattgcatct
     6601 gctccagcat gaacataagc ttttgctctt gtataggctt cttcttgacc caatttagca
     6661 attaaagctt cgacacgggc aatcaataca aaatcgtcat tttgctgagc catctttgcg
     6721 gctctaattt tcgcgcaaaa ttcttcagta ctgacaagaa tctgttgtct gtcgtcaaat
     6781 gagtttaatt ttggatatac tttatcttca atacaaactc cggcaatacc agcagcttcg
     6841 tattttttga tcatgcgggt gacattgtga atgttcccgt agccggaatc acagtcagcg
     6901 atgaccggca aattgcatga ttcattcata atgacggcgg cttcaagaaa ttcagtcatc
     6961 gttaatatac tggcatcagg tacagtttgc acagccgaga ttcccaaacc gcttgcccat
     7021 acggcattaa atccgttttt ctctgctaat ttggcgctta aaccgtcatg agctcccgca
     7081 actttcacca aacctttact gtttaaagca tctctaaaaa ttgatgattt tctgtttttc
     7141 accatcattc tccccttcac ctaatgatta tttttatttt gtcaatcgca tcatgtaatg
     7201 cgtgattgac ttctcgctca tttttcccct ttacaatcat ccatcctgct ctatcgtagc
     7261 tgtttttgat cggtctgatt ctatcaccga cactgcaatt tacatgaaaa tctactacat
     7321 tccccatcat tttgagatcg ctgatccctt tgattgcgcg tacaacccct tggttcgttt
     7381 ctaaaaaacg aacggcgcat acttcgcttt gagcatgttt cctttccggt tgatatggga
     7441 tgcccgccag ttccgcaaaa ataggtgtat gcatatcaca tttcatggcg atttctgtaa
     7501 tggtcactat gttgtctccg ccatagcggg tgtgtacctc gccaaccaca aatcctttat
     7561 ttgtgtgata cccttcaata tgcaaggggc caaatacgat ccccatggca tgaacaactt
     7621 ccttgaccag attcttatac aaatcctgat gtttttcttt atgtttatac ggcgatatat
     7681 gcccagattc tacaaaagtc ccggggtata gcaacttttc ggtcacacca aatatgtcga
     7741 ccttgccttg gcagacatcg gcttctattg aaatttcctg cccttctata aattcttcgg
     7801 ctaatactga cttctcctcg tcatgttttg aacactcttt aaaacacgcc tcaatgtcct
     7861 cttttttctc aacttttata acgcctatac tgccttgctg agatctcggc tttaaaatga
     7921 taggatgttg agatgtattc caaaaatcgt atacgtcttc cacgctcctg cacaatccaa
     7981 aatcgggaga gtttagtcct gcctttttta aaagccggcg cgttgtatat ttatcaaggc
     8041 atgcttgcac cacagacgga ggatttcctt ttaaatgaaa tgcctgctga agtttggata
     8101 cattgaataa gccggcttct ttgaaagtaa atatggcatc taaaggctct ttgtcatgga
     8161 tttctttagc gactgagaat agattctcat gattggtata atctaatgcg attttttggt
     8221 cagcttcctt tattaaatgc tcatattttt ttaatgaagc ttctgtatct cctaataaga
     8281 cgtcaaaacc aagttgtttt gccctcgtaa cggccttctc aatatgcgtt tcaggaatcc
     8341 cgatcaggaa cagtcttttc ctctccattg atgaaacacc tcacttcaga taaagcattt
     8401 tcagcatatt cgatcgcttt ttctgtatct tcggcttctg tgatgacata agcaatccgg
     8461 gaatcatgaa acttttcagg cggcaggcca acatgatcgc ccggctgctt ttctaaaaca
     8521 aattcaacga ccccgggcat ttctttgatc gattcgacac cttcccactt ttctatcaca
     8581 ccagcacggt ctgcaattaa aaacctgacg caggcagctc ttcttttcga agcttcaaag
     8641 cttattgttt ctcctaatac agccaatagg tttgcgcgcg ttatatttat acctttggct
     8701 agaggaacca aatgggtagt aataaaatcg ccgcccagac gaccgttgat ctcgataatc
     8761 ttgcaccctt tctctgtgat catgacctcg gcatgaaaac cacaattgtt cagctccaaa
     8821 gcttttatcc cttcactggt gatgtggaat aattcacgtt ccacagcctc cggcagcctg
     8881 gcgggaaatg catgctggta ttcttcgaaa tactgatccg tccatttttc agtaacacct
     8941 gcaaagtgaa tgactccgtc ggaaatcact ccctcaatgc tgacttcttg tccgttcata
     9001 aactcttcaa caatatactc gttttgataa aaagaaaaca ttttatcgtt ttccggcacc
     9061 gcggcgttta acagctgctg atatgcgcga tttaaatctt caggctttga tattcggaat
     9121 acgcctttac tggcagaagc acccacaggt ttaacgatca atgggtattc catatcaatg
     9181 cttgcatgat ataattcggt ccaatttgta aatttgcaat attttggatg aggaacttgt
     9241 gcgcggttca aacattgacg catcttccat ttgtttcgag cccgttctgc cgcttccacc
     9301 ggactgccct ttaagttaag ttctcgggca gttaccgcca ccggaaccac atctctatcc
     9361 cagaatgtaa tgactccatc aaaaggattt tctttggcag tttccttcag aacagctata
     9421 gtctcatcaa tctgataagt atttgcggaa atgtaatggt caacgaatgg ccgcgaccat
     9481 tcaggcagtt cagggccgac aacagaaacc gtcaagccca aatttttagc agtctccaaa
     9541 gtagaaattt ttttaatata agtagcatta aaaaataaaa tatgtttttc catccttccg
     9601 agcctctttc aacatttttt tctgcaaatt agaaaccttc tgcgtttcta aagaactgaa
     9661 tgcagaagat aaaaaacccc ttggaaaact caaaccatca tatgttttat ttgtatatat
     9721 tcataataac atacattatt tgttattaaa tgaatatttt atgaattcag ttttattaga
     9781 aaaaatgaaa ttatagggag aatattagga atacaactga ttaaaaaact cgaatatata
     9841 aaaaactgct gcacatcttc tccggtgtta atgataaaag gcccattatt cctagaacca
     9901 tgtaaattaa aaaagcctca aatctttata aataaaagat ttgaggcttt tctcattatt
     9961 cccactcaat cgttgcaggc ggcttgctcg taatgtcata cacgacgcgg ttgatgtgtt
    10021 tcacttcatt gacgatccgt gtcgaaatca cttcaagcac atcccaaggg atacgcgccc
    10081 agtcagatgt catgccgtca attgatgtta cggcacggat accgattgtg taatcatacg
    10141 ttctcgcatc tcccatgacg ccgacgctgc ggatgtcagg aagaaccgtg aagtactgcc
    10201 agatgtcgcg ctcaaggccg tggttcgcca cttcttcacg cagaatcgcg tctgattcac
    10261 gaacgatctc aagtttttct tccgttactt cgccgagtac gcggatgcca agtccagggc
    10321 ccgggaacgg ctgacgccat acgatatcat ccgggatgcc gagctctgtg ccgagcgcgc
    10381 gcacttcatc tttgaaaaga gtgttcagcg gttcgatcag ctcaaactgc atatcttcag
    10441 gaagtccgcc gacattgtgg tgcgatttga tcgtttgcgc agttgccgtt ccgctttcaa
    10501 taatgtctgt gtaaagcgtt ccttgtgcaa ggtagtcgat tcctttcagc ctgtccgctt
    10561 catcatcaaa cacgtaaatg aattcgttgc cgatgatttt gcgtttttgc tcaggatcag
    10621 aaacaccttt cagcttgttt aagaatctgt ctttcgcatc aactttaatg acattcatat
    10681 taaagccttc gctgaacgtt ttcatgacgc cttccgcttc gcctttgcgg agaaggccgt
    10741 gatctacgaa aatacaagtc agctggtcgc cgatcgcttt atgaatcaaa acggctacga
    10801 cagaagaatc gactccgccg ctcaaagcgc aaagcacttg tttgtctccg acggtttcgc
    10861 ggattttttg catttcgatt tcgataaagt tttccattga ccattcgcct ttacattcac
    10921 aaggcccgaa gacaaagttt ttcagaaggt catttccgta ttctgaatga cggacttccg
    10981 gatggaactg aacaccgtac cattttttgt cttttttgct catcgccgag ttcgggcagt
    11041 gatggcttgt cgcgtctacc gtaaaccctt ccggcacttg tacgactaag tcgccgtggc
    11101 tcatccagac aacttgttct tccggaagat ctttgaacaa gtcaggagtt ccttgaatct
    11161 gaatgctcgc ttttccgtat tcgcgctggc ttgccgcctc gactttccct ccgaggtaat
    11221 gagtcatcag ctgcatgccg tagcagatgc ccaatacagg aatatcaagt tcaaagattt
    11281 tttcatcaca gcggaaagac ccttcatcat atacactgtt tggtccgcct gaaaggataa
    11341 ttccttttgg attcatttct ttgatttcct cagctgtcaa cgtatgggga tgcagctcgc
    11401 tatatacgcc aaattcacgg atccggcggg taatcagctg gttatactga ctgccgaaat
    11461 caagaacaag aatcatttca ttcactaact tcgtcatggt tgtcacctaa tctcctctaa
    11521 gtttttgaca cagaaaaaac ggaggacaca cgttcagccc tctgtcggca agacttgtcc
    11581 ggaagcccgg ctttttaacg ctcccgggct cccatttaac attcatttat tctaacaaca
    11641 ggacgatatg cggtcaagac tatcttcttt taattatatt ttcccacaac tgtcccgatt
    11701 cattccaaag ctttgcggca ttatcgctgc ggtataacgc acgctcatag cgcagcgtca
    11761 gctcggacat gtcgtttgta tggtgcgcct cgtcaaccct cgcggcaaaa tcacggagcg
    11821 tttctccgtc tcccctgctg aacccttttc gtttcagctg tcggagcagt gcggcatatg
    11881 cgtcgaaaaa gacgtcttca tccgttcgcc gcttcaatct ggctgctgta acgtgcggaa
    11941 tccagcgcgc ccggagcagc caggcgagtg ccgccgcggc tgaaatcaaa atgacgatgg
    12001 ctgcatacgg ccatagctgt gccgcggttt tgttgcggat cacaggctgc ggtgccgcgc
    12061 tgtgatcccg ctttttcggc ttttcctctt tttccggctt tgtttcctga cgctgcttgt
    12121 cagacggttc atccgagttc cc
//
