LOCUS       gnlProkkaBJHFPPGC_13   16602 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|BJHFPPGC_13.
ACCESSION   gnlProkkaBJHFPPGC_13
VERSION     gnlProkkaBJHFPPGC_13
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2025-04-28 23:27:20
            Original ID  :: gnl|Prokka|BJHFPPGC_13
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16602
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16602
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[622:6602]"
                     /cutoff="20000"
                     /detection_rule="((LANC_like and (Lant_dehydr_N or
                     Lant_dehydr_C)) and not (YcaO or TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      623..6602
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="((LANC_like and (Lant_dehydr_N or
                     Lant_dehydr_C)) and not (YcaO or TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     cand_cluster    1..16602
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="((LANC_like and (Lant_dehydr_N or
                     Lant_dehydr_C)) and not (YcaO or TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..16602
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="lanthipeptide-class-i"
                     /region_number="1"
                     /rules="((LANC_like and (Lant_dehydr_N or Lant_dehydr_C))
                     and not (YcaO or TIGR03604))"
                     /tool="antismash"
     CDS             350..511
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03731"
                     /gene_functions="biosynthetic-additional (lanthipeptides)
                     predicted lanthipeptide"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg13_1"
                     /sec_met_domain="TIGR03731 (E-value: 2e-14, bitscore: 44.6,
                     seeds: 23, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATKDFNLDLVEVSKSNNGASTRITSHSFCSQACKTYKILGCNLL
                     THGCRFPR"
     CDS_motif       350..418
                     /prepeptide="leader"
                     /note="peptide class: {self.peptide_class}"
                     /note="predicted sequence: MATKDFNLDLVEVSKSNNGASTR"
                     /locus_tag="ctg13_1_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       419..511
                     /prepeptide="core"
                     /locus_tag="ctg13_1_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="21.80"
                     /molecular_weight="3277.8"
                     /monoisotopic_mass="3275.7"
                     /core_sequence="ITSHSFCSQACKTYKILGCNLLTHGCRFPR"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MATKDFNLDLVEVSKSNNGASTR"
                     /leader_location="[349:418](+)"
                     /alternative_weights="3295.9"
                     /alternative_weights="3313.9"
     CDS             623..3577
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155:Lantibiotic dehydratase domain protein (Score:
                     741.3; E-value: 2.5e-224)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg13_2"
                     /sec_met_domain="Lant_dehydr_N (E-value: 6.9e-93, bitscore:
                     303.0, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 5.5e-10,
                     bitscore: 31.2, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 9.5e-21, bitscore:
                     65.8, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINSFEARDFLVRNTYCSYKNEEFISYQQLVENCLLDQVFLEQLA
                     LANPKLFETLKRYSFGNLKKKREKSLFSSIFKYYKRSFQRSTPFGLFSETSIGKFAEEG
                     QSSLSSNTIKCVSLDSQWLIELVYKLENEFYESLSFSINGSNFESGDRIFQLYTVNNTD
                     LEEINIKLTNVYKIIEEACRDKFCSYSVILDKILKEYGLEYRSLAEQYILGLIKNHYLL
                     SNLQKDLVSRFNQENFIRILQNIDYEDKYTSSFKQIVSLINEYKTLKIGKGTNLLLDIY
                     QKMSSLVENENYLQVDLLSDSKVKLNVQHKKELERFANFIGNTQKSVRRSYLDDYRDKF
                     IEKYGVDQEVPLLELLDPTFGIGAPYGYVHPKSNFYENEPLTEFYSTQEQSKYLSEYIH
                     SIRENVDIDLEKFEDYYQLEENNKFNLQGLELFFNIVENNGKPAFSLSNIVGGSDIGSA
                     SGRFSILSDELRKYQKSLLDFIEEEDSTKKITSCEIEFIPENLRHRNIMRTMNVRDKTL
                     SLFTNNSKKQIHLKDIYIGINNEEKFYAKDIINNDIVKFHVTNMYNKMLFCNEIRFLYE
                     ISLDIDSINLPWELIYSNFDYVPRIMFGDIIVAPARWKICEGDIEKLSDINTFFINKRI
                     PQKFYLINGDNRILLSRKDKLDVEFIKNELIKKLKKDSIVELQEYIQDFGIFTKEVTDR
                     VADVVIPFVNNVKKDIGITAHAKRIDIESREKLPFDEWLYLKLYIGDNRQNEFIKEYLP
                     NIQEVVDSYQGELFYLRYADPNSHIRLRMKCDNLFDLYKQILNIISEGRKNRLISSVDI
                     STYDREIERYGGEDLLLEAEKIFCTDSRLMPRLLKICETNEMGFNLDSLSIVSVYLYLV
                     FFFDNDLHEIISFLETVSPKRNDKNKDINSDVKEYQKIIEANCNEKFFLCLKNPIKSLN
                     NKMLLNKLTKQQHYSIIDSIIHVHNNRLIGIDREKEKYIYFVLRRIFISKTHIK"
     CDS             3587..5425
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 165.8; E-value:
                     2.2e-50)"
                     /gene_kind="transport"
                     /locus_tag="ctg13_3"
                     /transl_table=11
                     /translation="MDKIESLTAKQFIRTILTIPNTLKLIFNIEKRYAIYLIILNVLTA
                     MSSLVSLIIFQELINSIYLSSSYLIFVVIIYFILQILISLLGQVESYIDGKFNFNLSYS
                     IDRKLMETINSLELSELEQSDMYNIIEKITQESTYKPYQLFNAILQVLSSVVTMISSLI
                     FIATWNISMAMLLGVIPIISLVMFLRIGQLEFLVQWERANEERETWYIRYLLTHDFSFK
                     EIKINDLSSYFIEKFSKFKQSFIKQDLKIARKKAYFNIILGIILNTINLFIALSIIIYV
                     RAGKLLIGNFVSLIQVVARVNSSSQSLIQNIYIVYNTSLFIEQLFEFMETNNVKKENKQ
                     ANITHLNKLDEINIHQLNYRYPNTEDYALKDINLSFTRGELVAIVGGNGSGKSTLVKLI
                     SGLYTPSSGVIEYDGMSGKFLDDTFYKENISVLFQDYVKYELSLRENIGLSDTNSMRKD
                     HEIIQLLEKLGLDFLKVNGSYDLDLQLGTWFRNGRQLSGGQWQKIALARTFFKKSSIYI
                     LDEPSSALDSISQKEIFDHFIELSKNDISIFVSHDLEAAKIADRIIVMRKGKVEDIGTH
                     SELFSRCKYYKELYKSQQYEEINEYGIKTTGYREDY"
     CDS             5382..6602
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140:Lanthionine synthetase C family protein (Score:
                     279.2; E-value: 8.7e-85)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg13_4"
                     /sec_met_domain="LANC_like (E-value: 6.3e-63, bitscore:
                     203.9, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNTELKQQAIEKIIEKWDRKLIENRNEMDFTELTFSSGIPGVVLL
                     LAEYGLREGFPNYSNKIETYIEYMVYKLSRYGMLTGSIYSGASGIALSILHLQEQPNYH
                     NLFNSLNDYIVYYVEEQIKSIDIDEISPLDYDIIEGLAGILNYLLLLNDSHYDEQKVKI
                     VNYLSNLANMEDKLLKFYIKSNNQMSELENNVYPTGCLNLGLAHGLSGVGCVLCYAYRK
                     GFGNNQTLIAIKNILNIYEDFELTDWQPFIWKDSLTKEEITTNKIIHQANFIRDAWCYG
                     SPGISLFYLYSGLILNDTYLKDKAEKILKASMDRLYGVDTNMLCHGYTGIIQICSLFKK
                     ILGTNSFNNYIEEFIGKEDEVIKSFGDDELEFLEGLSGCLLAFNELEDSTKLSYWKQPL
                     LLFEDFS"
     CDS             6615..7346
                     /locus_tag="ctg13_5"
                     /transl_table=11
                     /translation="MGRRTSIIVSILLVLLTGCGLNNTEKIEFSKTDFRHITFNHKDYS
                     ITDNEISKDSIRNVLVKDYKVIWINSHTGKILSKVSNNSCTLAIMNIFQTSDKLLCIGI
                     DDKYFQIAPKDQTSNLLNISRFSSKNTNIELDSGDDILIDDNNCRRIFYRGEAYYITSE
                     EVSSDKVGVYIDNLAEVRLFDAETGKKISNEERYAIYNKGEAKDRVNWFYGEVYSIKNS
                     KDDESLVVKINNVYRRAMKEE"
     CDS             7348..8946
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075:alkaline serine protease, subtilase family
                     (Score: 227.6; E-value: 5.8e-69)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg13_6"
                     /sec_met_domain="Peptidase_S8 (E-value: 3.2e-43, bitscore:
                     139.3, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRIIVLLFLVTCIGTVGVSYADTEDEPGGPIVSTKVFTDGELQN
                     KRENSSENKNINSDSNRLNDTSNQTGLRDDLSTDSDNADSTLINEESHSFWNYQWDMQY
                     VTDNGKSYEQYTPSKDISVGVIDSGITLDHPDLTNSLGSHLENFVPQNGFDGEEQEETG
                     VLNYVNDKLGHGTEVVGQITANGRVLGVSPGIIVNIYRVFGDSLADPKWINRAIRKAAD
                     DGNKVISLSMGQYLLISGSYDDGTNDLETYVIYKDAIDYASEKGSIVVASLGNEGLNEQ
                     DNSQMLHYLSSFHHVKEAGIVVDAPCIFDQVVAVGGLDMYGNISDFSNFTDKAIYAPAG
                     STINLKKYGPIEFLNKGFYLKDWIFTTSSTGWYQYVYGNSFAAPKVASAIALIADKYHI
                     TSPEQLKQFLFKNSPTINGNKVLKLTDLLNVGNADMFLYMSIENSISNFNIYSKSSIDH
                     SKITLQLKDVPKQLSYIITDTSIDHLNNKMLPPMGEKVGSDILLIGFLMIDLSALLICN
                     NLIIKYNSDKEVESA"
     CDS             8939..9625
                     /gene_functions="regulatory (smcogs) SMCOG1008:response
                     regulator (Score: 157.2; E-value: 8e-48)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg13_7"
                     /transl_table=11
                     /translation="MHKILIVDDDIDILKMMESALRLKNYKVETRSEINVPVRTQEFQG
                     FDVILLDIMMSNIEGTDICKCIRDSISTPIIFVSAKNDERDILTGFDVGGDDYITKPFS
                     LKQLVAKVEANIKREERRRGIHQTFTDVRRDFGPLTFYLEENRVCIDGKTIPFTSREYD
                     ILELLSSHPRKVFTIDDIYTRVYDEDADALLRSISEYIYQIRKKLSCYGVEPIKTVRGK
                     GYQWNV"
     CDS             9618..10955
                     /gene_functions="regulatory (smcogs) SMCOG1003:sensor
                     histidine kinase (Score: 110.6; E-value: 1.8e-33)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg13_8"
                     /transl_table=11
                     /translation="MFKRYSIRQRIWQFIVEIITGSLLVITLTMGMGVLLKQTGQLTLP
                     SSSSFSVDLGDVSISAINQKMRHIPYDYVIFDKKSGNILGGTYQKSDLLAYKLANNNSG
                     DVEKKGVTYTYASNEAVSIVVRHSTLPEFTNARLRHISYNKFSYVTVIVGIFLIIVVSV
                     YRLAREYQANFKEIQKLALNMGKSTLDFNNHLKILEFNDILNNLTEKNNELVYLINKER
                     HEKEDLSFQVGALSHDVRTPLTVLKGNIELLETTIISKEQSEFLEAMKRSLLRFDNYFS
                     QMMDYTKLLNEDDHKEYISLELFLSDTCLLLKEFANTYGVSYHEDIQVHNLDIYINSHA
                     LSRAITNIFVNACQYARKGSKQVYLNVYLKQDRLCFSIWNNGEPFSEGAKENASKLFYT
                     EDSGRTGKHYGIGLAFAKEVAFRHDGILELRNPPGGGAEVILQIKV"
     CDS             complement(11508..11675)
                     /locus_tag="ctg13_9"
                     /transl_table=11
                     /translation="MILSIVKSALQNAELKHKHSLDMARASGLFNMVLQATTTIFGVNM
                     KRIITLINSK"
     CDS             complement(11723..12718)
                     /locus_tag="ctg13_10"
                     /transl_table=11
                     /translation="MRQLTEICDFSFIYDELEKNFRPDFGRKTYSSIMMFKYLLLKDIY
                     KLSDVESFSNMAFKYFLGLSLEDSIIEPSSLTKFRKLRIKDERLLDLLITKSVQSALEH
                     SLIKSKILIMDATILKLTTIIRNPKRFSVNTQKSCVKQFTNAQKISKKFPSKPQEDNFE
                     DELRYIQELVSVLEKHKELITLLAVSQKLNYLKEAMEDDLEHLVSSVKEEDRLDHKSAN
                     SSFYGYKEHLAMTDERVITACVVTSSEKSDSPVLEELYHKSKDNGVSKEAILGDKAYSG
                     KDNIQFTKKECVHLVAKLHPAVSRGFRRKEDEFFYNKDAGLFVCPDTKES"
     CDS             complement(13025..13669)
                     /locus_tag="ctg13_11"
                     /transl_table=11
                     /translation="MLRSELLKLKNTTCLYLIISFSILQTLSIPLYVRFVPNGISLTNL
                     AILSFLCYPLLTAFLSILGIEQEKLANHYQEISSYPKKRLLWLVKLLITDLVLTLPSLF
                     GWLIINLLLKNWINGLLLMISSWMLIVFLNHFHYFIQVCLNSTSNIVISMVEIIFIIFA
                     SNKVFLTIHWLPITFPINSVLTTEWTPLNTLPYWLVGITLLFIYFVNFKYK"
     CDS             complement(13656..14384)
                     /locus_tag="ctg13_12"
                     /transl_table=11
                     /translation="MQKIFYSELLKLRHLGSNRFLIIIPFLTVLIAFLMGGLQIFVPFS
                     VYWWEAIFLYLVNGLLFIVDRRLEDQAGYFQNITNKHFTWKITLMKMVLIGMRTLISSL
                     FLLAFLYLVAFIYTDIIPINITKTSTSLILIWMTTLWNIPFLYLMSKYMSHFILLALNT
                     LVCLLIAPFIAQSPLWFVLPYTYHYKIAQFLLNLKPSGDVITNQNQTSILQVSLIIILS
                     MIMTLLLSYVLKRRESNATE"
     CDS             complement(14386..15063)
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 171.2; E-value:
                     4.8e-52)"
                     /gene_kind="transport"
                     /locus_tag="ctg13_13"
                     /transl_table=11
                     /translation="MQININQLSKSYKDKTILDNVTFTIESGTICGLLGVNGAGKSTLM
                     KILFGLVPKSDGEIQFDGLSKNKQSLGALIETPAIYHNLSAYDNLKTKALLYDIPDSKI
                     FETLEIIGLSNTGKKQAGKFSLGMKQRLGIGMAILTDPQFLILDEPTNGLDPDGINELL
                     NLIRSLKVTGMTILISSHQLLEISKIADHILILHQGKIQYDGKNKNVDSLESLFFKIVH
                     RGY"
     CDS             complement(15889..16071)
                     /locus_tag="ctg13_14"
                     /transl_table=11
                     /translation="MVHFYKFINELYILFNQLLTIFINNHFINLYFLIFPICKIKPEKK
                     HLVLDEMLSISINKF"
ORIGIN
        1 gtattactag ctattcactt tgtacaccag gatgcattac tggtgtactt atgggatgtc
       61 acatccaaag tattggatgt aatgttcatg tccatgtcag taaatagcgt aataatagtt
      121 tagaaaacat tctagtctta ttaagagagt ttcatcgctg aagtattaaa ggtaaacata
      181 agtcctcatt gtgtataaat aatagaagat caagaaataa ggaattctgt atattatctt
      241 acaaatattt attaatataa agttactaca cacgcactat ggtaacagtt tagtacttaa
      301 ttagcaagta ttctgtacta tactgataaa ttattaagga ggtgcttaaa tggctacaaa
      361 agattttaat ttagacttgg tagaagtctc aaaaagcaat aatggagctt caactcgaat
      421 tactagtcat tcattttgct cacaagcttg taagacttat aagattttag gatgtaattt
      481 actaacacac ggatgtaggt ttcctaggta ggaagacgct gaaatatttt gttggatagt
      541 gcatttttac actatcctat ttttataagt tactggaaat aggtatttaa taatttataa
      601 aagtaataaa ggagtcatta ttttgattaa ttcatttgaa gctagagatt ttttagttag
      661 aaatacatat tgttcatata aaaatgaaga atttatatcg taccaacaat tagttgaaaa
      721 ctgtttatta gatcaggtgt tcttagaaca gttagcctta gctaatccta agctattcga
      781 gacgttaaaa agatatagtt ttggcaatct aaaaaagaag agagaaaaaa gtttattttc
      841 gtctattttt aagtactata agaggagttt tcaacgctca acgccatttg gtttattcag
      901 tgaaacttca attggaaaat ttgctgaaga aggacaaagt agcttatcct ctaatactat
      961 taaatgtgtt tcacttgaca gtcagtggct aatagaactt gtctataaat tagagaatga
     1021 attttatgag tcactttcat ttagtattaa tggttcgaac tttgaatcag gtgatcgtat
     1081 ttttcaactt tatacagtga ataacacaga tttagaagaa attaatatca aattaactaa
     1141 tgtttataaa attattgaag aagcttgtag agataagttc tgtagttatt cagttatctt
     1201 agataaaatt ttaaaagagt atggacttga gtatcgcagt ttggcagaac agtatatttt
     1261 gggtctaatt aagaaccatt atttattatc taatttacag aaagacttag tttcgagatt
     1321 taatcaagag aattttataa gaatacttca gaatattgac tatgaggata aatatacttc
     1381 ttctttcaaa caaatagtaa gtttaattaa tgagtataaa acccttaaaa tcggaaaagg
     1441 aacaaacttg ttgttggaca tttatcaaaa aatgtctagt ctagttgaaa atgaaaatta
     1501 tcttcaagtt gatttgttaa gtgattctaa ggttaaacta aacgttcaac ataagaagga
     1561 acttgaacgt tttgctaact ttataggaaa tacacaaaag tcagttagac gcagctattt
     1621 ggatgattat agagataagt ttatcgagaa atatggagtt gatcaagagg ttccgttatt
     1681 agaattatta gatcctacgt ttggaatcgg tgctccgtat ggttatgtcc atccaaaaag
     1741 caatttctac gagaatgaac cgcttacaga gttttatagt actcaggagc aaagtaaata
     1801 tctgagtgaa tatatccatt caattagaga aaatgtagat atagacttag aaaaatttga
     1861 ggattattat caactagaag agaataataa gtttaatttg caaggtttgg aattattttt
     1921 taatattgtc gaaaataatg gaaaaccagc tttctcatta agtaatattg ttggtggaag
     1981 tgatattggt agtgcatcag gacgtttttc aattttatca gatgaactta ggaaatatca
     2041 aaaatcatta ttagatttta ttgaagaaga ggattcaact aagaaaatta cgtcctgtga
     2101 gattgaattt attcctgaaa atttaagaca tcggaatatc atgagaacaa tgaatgtaag
     2161 agataaaact ctttctttat ttactaataa tagtaagaaa caaattcatt tgaaagatat
     2221 ttatattggt ataaataatg aagaaaaatt ttacgccaaa gatataataa ataatgatat
     2281 tgtaaagttt catgttacga atatgtataa taaaatgtta ttttgtaatg aaattcgttt
     2341 tttgtatgaa atttctttag atattgattc tatcaattta ccatgggaat taatatatag
     2401 caatttcgat tatgtaccta gaattatgtt tggtgatatt atagttgctc ctgctagatg
     2461 gaaaatttgt gaaggagata tcgagaaact ttctgatatt aatacctttt tcataaataa
     2521 gcgaatccct cagaaatttt atcttatcaa tggagataat aggattttac tttcacgtaa
     2581 agacaaatta gacgttgaat ttattaaaaa tgagctaata aaaaaattaa aaaaagatag
     2641 tatcgtagaa ttacaagaat atattcagga ttttggaatt tttacaaagg aagtgactga
     2701 cagagtagct gacgtagtaa ttccgtttgt taataatgtg aaaaaagata ttggtataac
     2761 tgcacatgct aagagaatag atatagaatc acgagaaaaa ttaccttttg atgaatggtt
     2821 atatttgaaa ttatatattg gagataatag gcaaaatgag tttattaaag aatatctacc
     2881 taatattcaa gaggtagttg atagctatca aggagaattg ttttatctta ggtatgctga
     2941 tcccaattca catattcgac tacgcatgaa gtgtgataat ttatttgatt tgtataaaca
     3001 aattttaaat attatctctg aaggaagaaa gaatcgtttg atttcgagtg tagatatttc
     3061 tacatatgat cgtgagattg agagatatgg tggcgaggat ctgctgttgg aagccgaaaa
     3121 aattttttgt actgattcaa gattgatgcc acgattattg aagatttgtg aaacaaatga
     3181 aatggggttt aacttagaca gtctgtccat tgtaagtgtt tatttgtatc ttgtattctt
     3241 ctttgataat gaccttcatg agattatttc tttcttagag acagtgagtc ctaagagaaa
     3301 tgataaaaat aaagatataa atagtgatgt taaggagtat cagaaaatta ttgaagctaa
     3361 ttgtaatgaa aaattctttc tatgcttaaa aaatccaata aaaagcttaa acaataaaat
     3421 gttactaaat aaacttacaa agcaacaaca ttattcgata attgatagta ttattcatgt
     3481 tcataataat cgtttaattg ggattgatag agaaaaagaa aaatatattt attttgttct
     3541 tcgacgcata ttcattagta aaacacatat taagtaggag tatataatgg acaaaatcga
     3601 gagcctgact gcaaaacagt ttattaggac tatacttact attccaaata cattgaaatt
     3661 gattttcaat attgaaaaaa gatatgcgat ttatttaatt attttaaatg ttttgacagc
     3721 gatgtcttca ttggttagtc ttattatttt tcaagaattg attaattcta tttatttatc
     3781 atcaagttat ttaatttttg tagtaattat ttattttatt ttgcaaatac ttatctcatt
     3841 gttgggtcaa gttgagagtt atattgatgg gaaatttaat ttcaatctgt cctatagtat
     3901 tgatagaaaa ttaatggaaa cgattaactc ccttgagtta agtgaacttg agcagtctga
     3961 tatgtataac attattgaga aaataactca agaaagcacc tataaaccat atcaattatt
     4021 taatgcaatc ttacaggtgc tatcatcagt agttacgatg atatctagct tgatattcat
     4081 tgcaacatgg aatatcagta tggctatgtt attaggagtt attcctatta tttctttagt
     4141 aatgtttttg aggattggtc aattagaatt tttggttcaa tgggagagag ctaatgaaga
     4201 acgggagaca tggtacataa gatatctact tactcatgat ttttcattta aagagattaa
     4261 gataaatgat ttaagtagtt attttattga gaaattttca aaatttaaac aaagctttat
     4321 caagcaggat cttaagattg ctagaaaaaa agcatatttt aatataatct taggtatcat
     4381 attaaataca attaatttat ttattgcttt atcaattatt atttatgtaa gagcaggaaa
     4441 acttcttata ggtaattttg ttagtttaat acaggttgtt gcacgagtga atagttcctc
     4501 acagtcatta attcaaaata tctatatagt gtataataca agtttattta tcgagcaatt
     4561 atttgaattt atggagacta ataatgtaaa gaaagagaac aaacaagcta atattacgca
     4621 tctaaataag ttagatgaaa ttaatattca tcaacttaac tacagatacc caaatacaga
     4681 agattatgct ttaaaagaca tcaatttatc ctttacaagg ggtgaattag tagctattgt
     4741 tggtggaaat ggctcaggta agagtacact ggttaaatta atttcaggat tatatacacc
     4801 atcaagtggt gtaatagaat atgatggtat gtccggaaaa tttttggatg atacattcta
     4861 taaagagaat atatcagtgc tttttcaaga ttatgttaag tatgagttat cattaagaga
     4921 gaatatagga ctgagtgata ctaattcgat gagaaaggac cacgaaatta ttcaattatt
     4981 agaaaaattg ggactagatt ttcttaaagt taatggtagc tatgatcttg atttacaatt
     5041 aggtacatgg tttagaaatg gtagacaact gtcaggaggg cagtggcaaa aaattgctct
     5101 agcaagaact ttctttaaaa aatcatccat ctatatttta gatgaaccaa gttcggccct
     5161 tgattcaata tctcaaaaag aaatttttga tcatttcatt gagttgtcaa aaaatgatat
     5221 ctctattttt gtatcacatg atttagaagc agctaaaata gcagatagaa ttattgttat
     5281 gagaaaagga aaagttgagg acattggaac acacagtgaa ttattttcac gatgtaagta
     5341 ttataaagaa ctatataaat cacagcagta tgaggaaata aatgaatacg gaattaaaac
     5401 aacaggctat agagaagatt attgaaaagt gggatcgtaa acttatcgaa aatagaaatg
     5461 aaatggactt cacggagcta acattttcaa gtggtatacc aggagttgtt ctcttactag
     5521 cggagtatgg tctccgagag gggtttccaa attatagcaa taaaatagaa acttacatcg
     5581 agtatatggt ttataaatta tccagatatg gtatgttgac tggttcaatt tattccggag
     5641 ctagcggaat agcattaagt attcttcatt tacaagagca acctaattat cataatcttt
     5701 ttaatagtct taatgactat atagtatatt atgttgagga gcaaattaaa tctattgata
     5761 ttgatgaaat ctcacctcta gattatgata ttattgaggg attggcagga atactgaact
     5821 atttacttct cctaaacgat tctcactatg atgagcagaa agtaaagatt gtaaattact
     5881 tatcaaactt agctaatatg gaagataagc tattaaaatt ttatatcaaa tcaaataatc
     5941 aaatgtctga attggagaat aatgtatatc caacgggatg ccttaactta ggactagctc
     6001 acggcctttc tggtgttggt tgcgttttat gctatgcgta taggaaggga tttgggaata
     6061 atcagacttt aatagcaatt aagaatattc tcaatatata tgaagatttt gaattgacgg
     6121 attggcaacc gtttatttgg aaagattctt taactaagga agagattact actaataaga
     6181 ttatccatca ggcaaacttt ataagagatg cgtggtgtta tggtagtcca ggtataagct
     6241 tattttactt atatagtgga ttaattttaa atgataccta cttaaaagac aaggcggaaa
     6301 aaatattaaa ggcatctatg gatagattat atggtgtaga cacaaatatg ctttgtcatg
     6361 gttatactgg aataattcaa atctgttcat tatttaaaaa aattcttgga acgaattctt
     6421 ttaataacta tattgaagag tttattggga aagaggatga agtaataaag agttttggag
     6481 acgatgaatt agagtttctt gaaggactga gtggatgttt acttgctttt aatgaacttg
     6541 aagattcgac aaaattgtca tattggaaac aaccattact actttttgaa gattttagct
     6601 agaaaggaat ataaatggga cgacgaacaa gcattatagt gtctatttta cttgtattgt
     6661 tgacaggatg tggactaaat aatacggaga aaatagagtt ttctaaaaca gattttagac
     6721 atataacgtt taatcacaaa gattattcaa tcactgataa tgaaatttct aaagatagta
     6781 taaggaatgt tttggtaaaa gactataaag tgatttggat taactctcat acaggaaaaa
     6841 ttctctcaaa agtatcaaat aacagttgta cactggcaat aatgaatata tttcaaacaa
     6901 gtgataaact actgtgtatt ggtattgatg ataagtattt tcaaattgct ccgaaagatc
     6961 aaacatctaa tctgttaaat atatctagat tcagtagcaa aaacacaaat attgaattgg
     7021 acagtggaga cgatatttta atcgatgata ataattgtag gagaatattc taccgaggag
     7081 aagcttatta cataacaagt gaagaagtat cgagtgataa ggtaggagtt tatattgaca
     7141 atttggcaga ggtaagactc tttgatgctg agactggaaa gaaaatttcg aatgaggagc
     7201 gttatgcaat ttataataag ggagaagcta aagatcgagt gaattggttt tatggagaag
     7261 tatattccat aaagaattca aaagatgatg agtcccttgt ggttaagatt aataatgttt
     7321 acaggcgtgc aatgaaggaa gagtaggatg aaaagaatca tagttttatt gtttttggta
     7381 acttgtattg ggacagtagg agtaagctat gcagataccg aagatgaacc aggtggtccg
     7441 atagtttcta caaaagtatt tacagatgga gaattacaaa acaagaggga aaactcttca
     7501 gaaaataaga atatcaattc agattcaaat cgattaaatg atactagtaa tcaaactggc
     7561 ttaagggatg acttgtcaac tgatagtgat aatgctgata gtacactgat aaatgaagag
     7621 agtcatagtt tttggaatta tcagtgggac atgcagtatg ttaccgataa tggtaaaagc
     7681 tatgaacaat acactccttc taaggatatt tctgttggag taatcgattc aggtattact
     7741 ttggatcatc cggatttaac taatagttta ggtagccatt tagaaaattt tgttccccaa
     7801 aatggttttg atggtgaaga acaagaagaa acaggggtgc taaattatgt caatgataaa
     7861 ttgggacatg gtaccgaagt tgtagggcag ataacagcga atggacgagt tttgggagtc
     7921 tccccaggta tcattgtaaa tatttatcgt gtctttggag attcacttgc tgatcctaaa
     7981 tggattaata gggcaataag aaaagcagct gatgatggta ataaagttat ttcacttagt
     8041 atgggacaat atttattaat ttcaggttct tatgatgatg gaacgaatga tttggagact
     8101 tatgttatat ataaagatgc cattgattat gcaagtgaga aaggatccat tgtagttgct
     8161 tctctaggga atgagggttt aaatgaacaa gataattcac aaatgttgca ttatcttagc
     8221 agttttcatc atgtaaaaga agcagggata gtagtggatg cgccttgcat attcgaccag
     8281 gttgttgcgg tcggaggact cgatatgtat gggaatattt cagactttag taacttcact
     8341 gataaagcaa tctatgctcc tgcgggttca acaattaatc ttaaaaagta tggtcctata
     8401 gaatttttaa ataaaggttt ctatttaaaa gattggattt ttacaactag ttctacaggg
     8461 tggtatcagt atgtgtatgg aaattctttt gctgctccga aagttgcttc agctatagca
     8521 ttaatagcag ataagtatca tattacgtca ccagaacaat tgaaacaatt tctttttaaa
     8581 aactcaccga ctattaacgg aaataaggta ctaaaattaa ctgatctttt gaatgtggga
     8641 aatgcagata tgtttctcta tatgagtata gaaaatagta tatcaaactt taatatatat
     8701 tctaagtcga gtattgatca ttcaaagata acacttcaat taaaggatgt cccgaaacaa
     8761 ctttcttata ttattaccga tactagtatt gatcatctga ataataaaat gttgcctccg
     8821 atgggtgaga aggtaggctc tgatatattg ctaattggtt ttttgatgat tgatttgtct
     8881 gcattattaa tttgtaataa tttaattata aagtataata gtgataagga ggtagaaagt
     8941 gcataaaatt cttattgtag atgatgatat tgatatttta aaaatgatgg aatcagctct
     9001 tcgattaaaa aactataagg tggagacgcg atcagaaatt aatgttccag tacgaactca
     9061 agaatttcaa ggatttgatg ttatattatt agatattatg atgtcgaaca ttgaagggac
     9121 agatatctgt aaatgtatca gagattctat ttcaactcca ataatttttg ttagtgctaa
     9181 aaatgatgaa agagatattt taactggatt cgacgtaggt ggtgatgact acattactaa
     9241 accctttagt ttaaaacagc tagttgccaa agtagaagca aatattaagc gtgaggagcg
     9301 tcgtaggggg atacaccaaa cctttactga tgttagacgt gactttggac ctttaacctt
     9361 ctatctcgaa gagaatcgtg tttgcattga tggtaaaacg attcccttta ctagtaggga
     9421 atacgatatt ttggaacttt tatcaagcca tcctagaaaa gtatttacaa ttgatgatat
     9481 ttatacacgt gtttatgatg aggatgcgga tgcacttctt cgttctattt cggaatatat
     9541 ttatcaaata agaaaaaaac tatcatgtta tggtgtagaa cctataaaaa ccgttagagg
     9601 taaggggtac cagtggaatg tttaaacgat actctatacg ccaacgtatt tggcaattta
     9661 ttgttgaaat cataactggt tctcttcttg tgattactct taccatgggt atgggagtat
     9721 tgttgaaaca aacgggacaa ctgaccttac catcttcttc gagtttctcg gttgatttgg
     9781 gtgatgtctc tatatcagca attaaccaaa aaatgaggca cattccttat gactatgtaa
     9841 tctttgataa aaaatcaggt aatattttgg gtggaaccta tcaaaaaagt gatttactag
     9901 catataaact tgcaaataac aatagtggag atgttgaaaa aaagggggtt acttatacct
     9961 atgcaagtaa cgaggcagta tctatagttg taagacatag cactcttcca gaatttacca
    10021 atgctagact acgccatatt agttataaca agttttccta tgtaactgta attgttggaa
    10081 ttttcttaat aattgttgtt tcggtatatc gtttagctag ggaatatcag gctaatttta
    10141 aagaaattca aaaactagca ttaaatatgg gaaaatcaac tctagatttt aacaaccatt
    10201 taaaaatatt agaatttaac gatattttga acaatctaac agaaaaaaat aacgaattag
    10261 tatatttaat aaataaagag agacatgaaa aagaagattt atcatttcaa gtaggagcgc
    10321 tttcacatga tgtaagaaca cccttgactg ttctgaaggg taatatagag cttttggaaa
    10381 cgacgattat ttctaaggaa caaagtgagt ttttagaagc tatgaagcgt tcattgttac
    10441 gatttgataa ttatttttct caaatgatgg attatactaa attattaaat gaagatgatc
    10501 ataaggagta tatttcgtta gaattatttt tatcagatac atgcttatta ttaaaggagt
    10561 ttgctaatac gtatggtgtt tcctatcatg aagatattca agtccataac ttagatattt
    10621 atatcaatag tcatgctttg tcaagagcga taactaatat ttttgtaaat gcatgccaat
    10681 atgctagaaa aggtagtaaa caggtttatt taaacgtata tttgaaacaa gataggttat
    10741 gcttttcaat atggaataat ggggaaccat tttctgaagg tgcaaaagaa aatgcgagta
    10801 agctatttta tacagaggat tctggaagga ctggtaaaca ttatgggata ggcttagctt
    10861 ttgctaaaga agtagctttc agacatgatg gaattttaga gttgagaaat cccccagggg
    10921 gtggagcaga agtgatttta caaattaaag tatgatacga gaaaggttga agcaaatgat
    10981 aaactaccca aaagagatat tttagataaa agtgctctca agtatctgct gactccaaaa
    11041 aaattagaca aataatttaa gtggctcttt tctaccattt gtcaagtcta tcatgaaata
    11101 tgacagtagc ttttctgaag tcgctgtctt atttttaaca cttatttagc tataaaaggg
    11161 catgcaaaat aacacctcat ctaggtattt ttaaacaagg tgttacagta atacagcata
    11221 gacaactata tcgattatgg gcggaagagt aatcgtaaag tttgttatgc gtaatgaggt
    11281 aatagtaatg aggtaataca ttgtccgaat gagacgatgt atagagacaa tcgcatgtgg
    11341 cttggttgaa gctattgtgg ctctctgtca actgtagtgg gtaacgaaaa gctaacatct
    11401 agagaagacc ggatagggag cccactgaaa aagtaatctc tacagtttaa ataaaataaa
    11461 aaggagtaat ctacctaaat atgagataga tttctccttt tgtttactta ttttgaattt
    11521 attaaagtta taatcctctt catattgacc ccgaatatag ttgttgtcgc ttgtaacacc
    11581 atattgaaaa gacctgatgc tctagccata tcaagactat gtttgtgttt aagttccgca
    11641 ttttgaaggg cagatttgac aatacttaat atcaaaacag tgggtttcct gagaattata
    11701 tttccccgtt gttcttccta tcttagcttt ctttagtatc tggacaaaca aagagacctg
    11761 catccttgtt atagaagaat tcatcttctt tccgacgaaa gcctcttgaa acagcaggat
    11821 gtagcttagc gactaaatgc acacattctt ttttggtaaa ttgaatatta tctttcccag
    11881 aataggcctt atcccctaga atagcttctt tgcttacacc attatcctta gatttatgat
    11941 agagttcttc taagacagga ctatcacttt tttcactgga tgtcacgaca caggctgtga
    12001 tcacacgttc atctgtcatg gcgagatgct ctttatagcc ataaaaggaa ctattcgcag
    12061 atttatggtc aagacgatct tcttctttaa cagaggatac caagtgttct aaatcatcct
    12121 ccatagcttc tttaaggtaa tttaattttt gcgaaaccgc aagtaaagtt atcaattctt
    12181 tatgtttttc taggactgat accaactctt gtatatatct taattcatct tcaaaattat
    12241 cttcttgagg cttgctagga aacttctttg atatcttctg agcattggta aattgtttta
    12301 cgcaagactt ttgagtgttc acggagaacc tcttggggtt tcttatgatt gtagtgagct
    12361 ttagtatggt cgcatccata atgagaattt tacttttaat caagctatgc tcaagagcgc
    12421 tttgtacaga tttagtgatg agtaaatcaa gtaatcgttc atctttgatt cgaagtttgc
    12481 gaaatttagt caatgaagag ggttcaataa tgctatcctc tagagataga ccaaggaagt
    12541 atttaaaagc catattagaa aaggactcca catcggataa cttatagatg tcttttaata
    12601 agagatattt gaacatcata atcgacgaat aagttttacg tccaaagtca ggacgaaaat
    12661 tcttttctaa ctcatcgtaa ataaagctaa aatcacagat ttccgttagc tgacgcaaaa
    12721 aatgattctt tggaacaaca atatcatata gactggaata gggactaact tctaaagtta
    12781 actgattatc aagtatacaa tcacctcgag tttagtataa caaaaaagcc atcgattgat
    12841 gactttttca gtgggctccc ggctaggtct tctctttttt tatgttcaga gtcatgaata
    12901 cacgcttctt aaagctgatg aagtttctaa aaccgaagcc caggcgtttg atgtctttga
    12961 tcaacttatt agttgcttcg agtttcgcgt ttgaatagtc tgtttctagt gcatctttga
    13021 tgtattattt gtatttaaag tttacaaaat agataaataa tagcgtgatt cctacaagcc
    13081 aataaggaag agtgttgagt ggagtccact ctgtagtgag aacactgtta ataggaaaag
    13141 taataggaag ccaatgaata gttaagaaga ctttattact agcgaaaata ataaaaatga
    13201 tttcaaccat agaaataacg atgttactcg tactatttag acaaacttgt ataaaataat
    13261 gaaaatgatt aagaaagaca attagcatcc aacttgatat cattagcagg agaccattaa
    13321 tccaattctt aaggaggagg tttatgatta accacccaaa taaagaaggc agggtaagga
    13381 ctaagtctgt tattaaaagt ttgactagcc acaggagtct tttcttaggg taactagaga
    13441 tttcttgata atgattagcg agtttttctt gttcaattcc taaaatggat aagaaagctg
    13501 tcaatagagg ataacataaa aaggataaga tagctagatt agttagagaa atgccattag
    13561 ggacgaatct tacatagagg ggaattgaaa gagtttgtag tatagaaaaa ctgataataa
    13621 gatagagaca tgtagtattc tttaatttaa gtaactcact ccgtagcatt tgactccctc
    13681 ctttttagga catatgataa aagtaatgtc attatcattg ataaaataat aataagtgac
    13741 acttgcaaaa tgctggtttg gttttgattt gtaataacgt cgcccgatgg tttaaggttt
    13801 aataaaaatt gagctatttt atagtgatag gtatagggca agacgaacca gagtggactt
    13861 tgagcaataa atggtgctat taaaagacaa accagtgtat taagcgctaa tagaatgaaa
    13921 tgactcatgt atttagacat cagatacaga aaaggaatat tccataaagt tgtcatccaa
    13981 attaagatta atgaagtaga tgttttagta atgtttattg ggataatatc tgtgtaaata
    14041 aaagcaacga gatacaggaa agctagtaag aataaactag aaatcaatgt tctcattccg
    14101 ataagcacca ttttcatcaa ggtaattttc caagtgaaat gcttgttagt aatattttga
    14161 aaataccctg cctgatcttc caaacgtcta tcaactatga ataaaagacc atttacgaga
    14221 tataaaaaga tagcttccca ccaatagact gaaaaaggaa caaaaatctg tagtcctccc
    14281 attaaaaagg ctattaggac agttaaaaac ggtatgataa ttaagaatct attggatcct
    14341 aaatgtcgta atttgagcaa ttctgagtag aatatctttt gcatatcagt accccctatg
    14401 aacgatttta aagaataaac tttccagact atctacattc ttattcttac cgtcatattg
    14461 tatctttcct tgatgtagaa ttagaatgtg atcggcaatt ttgctgattt ctaaaagttg
    14521 atggctagaa atcagaattg tcatccctgt tacttttaat gaacgaataa ggtttaacag
    14581 ttcgtttata ccatcaggat caagtccatt agtaggctca tcgagaatta aaaattgggg
    14641 atcagttaaa atagccatgc caattcctag tctctgcttc atccctaatg aaaatttacc
    14701 cgcttgtttt ttcccggtgt tagaaagacc aattatttct aaggtttcaa aaatttttga
    14761 atcaggaatg tcatataata gcgctttcgt ttttaaattg tcataggctg aaaggttatg
    14821 ataaatagca ggtgtttcaa ttaatgcgcc taatgattgt ttgttttttg ataatccatc
    14881 aaattgaatc tctccatcac tttttggaac caaaccaaag agaattttca tcagagttga
    14941 cttaccagca ccattaaccc ctaatagacc acaaattgta cccgattcaa tggtaaaagt
    15001 gacattgtcc aatatagttt tatctttata ggattttgaa agttgattga tatttatttg
    15061 catgtgaatg cctcctatca gttattgtta cattcattat aagatctgat tttcagagtt
    15121 atgtcagaaa taactgttta aatggaagaa ttgactgcat cttcatagct agattgacta
    15181 tttagtgaat tattaaggaa cttatattga attactcaaa agttagcagt atttataaaa
    15241 tttctatggt actaacttgg tagcataaat ttttccaata ttataggatc aattcaatat
    15301 tacaggtaga aatattgtat cagtcttgaa aaatactgtg ttaggtcatt acagtaccaa
    15361 aataaagcac attaatcttt ttattgaaga tggggagttt aaatggatta tctattaaaa
    15421 atcgttttac aatctttgac atgagctacg attatgtatt tggaaagtta tatttagaaa
    15481 ttgaataata ctggttgaat atttctggtg aagatgccca gagcgtgaat atgtgataac
    15541 atatattttt actaaatttg tatctttagt tagaatgtta aattaacaga atagatatta
    15601 gtgactactg ttcatattga gaaaatttca gagaaactct acttttgata tggtttgaaa
    15661 ttaatttttg aattggaact attataaagt ggtagagata ctaaactatg taaacaaata
    15721 tttgttggaa tttccctcat ctagtaatac ctattaaaat tttttgaatt aaagaagtag
    15781 tataaaacgg ttagatgtta atatatggct attctaaaac tatatgaaat ttaaccctgt
    15841 caaaccaggc ttgaaaaaag cccgtaaagc gtcacaattt agtaaacgtt aaaacttatt
    15901 tatacttatt gaaagcattt cgtctaatac gagatgcttt ttttctggtt taattttaca
    15961 aattgggaaa attaaaaagt acaaattaat gaagtgatta ttgataaaaa tagttaataa
    16021 ttggttaaac aaaatatata actcgtttat aaatttatag aaatgaacca ttataaatct
    16081 cctcttaaat attgaaaaaa tcattggcag tggacatact ttaagactat atatttctga
    16141 aactagtttc acaatacaaa tattgacatg caattattaa ttggtggatt ttaagttgac
    16201 atctacaaag tttaatgtta gaatacattc aaaaatatat ttgaatgagg tgttttatga
    16261 ttcaaaatat tgttacttca ataatcctgt attctgggac agccgtagac ttacttatta
    16321 tcctaatgtt attttttgcc aaaagaaaaa gcagaaagga catcattaac atctatttag
    16381 gacaatttct aggctctgtt agtctaatat tcctaagttt gctttttgca tttgtcttaa
    16441 attatattcc tagtaaagag attttaggtt tactcggttt gattccaatt ttcctaggcc
    16501 tcaaagtttt gcttttagga gattctgatg gagaagctat tgcaaaagat ggtttgcgaa
    16561 aagacaataa aaacttgatt tttctagtcg ttatgattac tt
//
