GCA_047463215.1 - 6 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

gnlProkkaCMHDLHII_1 (original name was: gnl|Prokka|CMHDLHII_1)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1.1	RiPP-like	54,914	73,756
Region 1.2	RiPP-like	152,990	163,286

gnlProkkaCMHDLHII_3 (original name was: gnl|Prokka|CMHDLHII_3)

Region	Type	From	To	Most similar known cluster		Similarity
Region 3.1	RiPP-like	102,411	114,507	quinolidomicin A	Polyketide	3%

gnlProkkaCMHDLHII_6 (original name was: gnl|Prokka|CMHDLHII_6)

Region	Type	From	To	Most similar known cluster		Similarity
Region 6.1	RaS-RiPP	1	13,897
Region 6.2	transAT-PKS,NRPS,RRE-containing	83,820	136,806	nisin Q	RiPP:Lanthipeptide	45%

gnlProkkaCMHDLHII_15 (original name was: gnl|Prokka|CMHDLHII_15)

Region	Type	From	To	Most similar known cluster		Similarity
Region 15.1	T3PKS	1	21,439

Region	Type	From	To	Most similar known cluster	Similarity
Region 1.1	RiPP-like	54,914	73,756
Region 1.2	RiPP-like	152,990	163,286
Region 3.1	RiPP-like	102,411	114,507	quinolidomicin A	Polyketide	3%
Region 6.1	RaS-RiPP	1	13,897
Region 6.2	transAT-PKS,NRPS,RRE-containing	83,820	136,806	nisin Q	RiPP:Lanthipeptide	45%
Region 15.1	T3PKS	1	21,439

No secondary metabolite regions were found in these records:: gnlProkkaCMHDLHII_2 (original name was: gnl|Prokka|CMHDLHII_2); gnlProkkaCMHDLHII_4 (original name was: gnl|Prokka|CMHDLHII_4); gnlProkkaCMHDLHII_5 (original name was: gnl|Prokka|CMHDLHII_5); gnlProkkaCMHDLHII_7 (original name was: gnl|Prokka|CMHDLHII_7); gnlProkkaCMHDLHII_8 (original name was: gnl|Prokka|CMHDLHII_8); gnlProkkaCMHDLHII_9 (original name was: gnl|Prokka|CMHDLHII_9); gnlProkkaCMHDLHII_10 (original name was: gnl|Prokka|CMHDLHII_10); gnlProkkaCMHDLHII_11 (original name was: gnl|Prokka|CMHDLHII_11); gnlProkkaCMHDLHII_12 (original name was: gnl|Prokka|CMHDLHII_12); gnlProkkaCMHDLHII_13 (original name was: gnl|Prokka|CMHDLHII_13); gnlProkkaCMHDLHII_14 (original name was: gnl|Prokka|CMHDLHII_14); gnlProkkaCMHDLHII_16 (original name was: gnl|Prokka|CMHDLHII_16); gnlProkkaCMHDLHII_17 (original name was: gnl|Prokka|CMHDLHII_17); gnlProkkaCMHDLHII_18 (original name was: gnl|Prokka|CMHDLHII_18); gnlProkkaCMHDLHII_19 (original name was: gnl|Prokka|CMHDLHII_19); gnlProkkaCMHDLHII_20 (original name was: gnl|Prokka|CMHDLHII_20); gnlProkkaCMHDLHII_21 (original name was: gnl|Prokka|CMHDLHII_21); gnlProkkaCMHDLHII_22 (original name was: gnl|Prokka|CMHDLHII_22); gnlProkkaCMHDLHII_23 (original name was: gnl|Prokka|CMHDLHII_23); gnlProkkaCMHDLHII_24 (original name was: gnl|Prokka|CMHDLHII_24); gnlProkkaCMHDLHII_25 (original name was: gnl|Prokka|CMHDLHII_25); gnlProkkaCMHDLHII_26 (original name was: gnl|Prokka|CMHDLHII_26); gnlProkkaCMHDLHII_27 (original name was: gnl|Prokka|CMHDLHII_27); gnlProkkaCMHDLHII_28 (original name was: gnl|Prokka|CMHDLHII_28); gnlProkkaCMHDLHII_29 (original name was: gnl|Prokka|CMHDLHII_29); gnlProkkaCMHDLHII_30 (original name was: gnl|Prokka|CMHDLHII_30); gnlProkkaCMHDLHII_31 (original name was: gnl|Prokka|CMHDLHII_31); gnlProkkaCMHDLHII_32 (original name was: gnl|Prokka|CMHDLHII_32); gnlProkkaCMHDLHII_33 (original name was: gnl|Prokka|CMHDLHII_33); gnlProkkaCMHDLHII_34 (original name was: gnl|Prokka|CMHDLHII_34)

Compact view

gnlProkkaCMHDLHII_1 - Region 1 - RiPP-like

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Location: 54,914 - 73,756 nt. (total: 18,843 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

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core biosynthetic genes

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Similar known gene clusters from MIBiG 3.1

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gnlProkkaCMHDLHII_1 - Region 2 - RiPP-like

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Location: 152,990 - 163,286 nt. (total: 10,297 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

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core biosynthetic genes

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transport-related genes

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resistance

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
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gnlProkkaCMHDLHII_3 - Region 1 - RiPP-like

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Location: 102,411 - 114,507 nt. (total: 12,097 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

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core biosynthetic genes

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resistance

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Similar known gene clusters from MIBiG 3.1

gnlProkkaCMHDLHII_6 - Region 1 - RaS-RiPP

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Location: 1 - 13,897 nt. (total: 13,897 nt) Show pHMM detection rules used

Region on contig edge.

RaS-RiPP: (PF04055 and TIGR01716)

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core biosynthetic genes

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
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gnlProkkaCMHDLHII_6 - Region 2 - NRPS,RRE-containing,transAT-PKS

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Location: 83,820 - 136,806 nt. (total: 52,987 nt) Show pHMM detection rules used

Region on contig edge.

transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))
NRPS: cds(Condensation and (AMP-binding or A-OX))
RRE-containing: minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])

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NRPS/PKS domains

KnownClusterBlast

NRPS/PKS modules

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 2, location 83819 - 136806:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X - mal) + (Cys) + (ohmal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

ctg6_108

AMP-binding (11..360): X

nrpys: Phe, Trp

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: Unpolar aromatic ring (Phe, Trp)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: IPWTILDTLK
Nearest Stachelhaus code(s):: 3,4-dohBza MPWAIGDVLK (47% 8Å match)
Stachelhaus code match:: 60% (weak)

ctg6_109

Search NORINE for peptide: strict or relaxed

AMP-binding (824..1226): Cys

nrpys: Cys

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Polar, uncharged (aliphatic with -SH) (Cys)
Small clusters prediction:: Polar, uncharged (aliphatic with -SH) (Cys)
Single AA prediction:: Polar, uncharged (aliphatic with -SH) (Cys)

Stachelhaus prediction details:

Stachelhaus sequence:: DLFNLSLVWK
Nearest Stachelhaus code(s):: Cys DLFNLSLVWK (76% 8Å match)
Stachelhaus code match:: 100% (strong)

ctg6_114

PKS_AT (6..282): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 79.2%; inactive: 70.8%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 67.0
inactive: 35.5
Methoxymalonyl-CoA: 15.9
Methylmalonyl-CoA: 11.2
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Propionyl-CoA: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

gnlProkkaCMHDLHII_15 - Region 1 - T3PKS

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Location: 1 - 21,439 nt. (total: 21,439 nt) Show pHMM detection rules used

Region on contig edge.

T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

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core biosynthetic genes

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
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Similar known gene clusters from MIBiG 3.1

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