LOCUS       c00005_gnlPro..        15135 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|IAJLEBKO_5.
ACCESSION   c00005_gnlPro..
VERSION     c00005_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2025-05-01 00:26:22
            Original ID  :: gnl|Prokka|IAJLEBKO_5
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15135
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(1..162)
                     /locus_tag="ctg5_1"
                     /transl_table=11
                     /translation="MGTRVSYPVEVKQKAVEMRLAGVPMKEILQELNIKNKTQVQTWVR
                     WYKAGDTHR"
     protocluster    1..15135
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1844:5135]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1845..5135
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..15135
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15135
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             476..661
                     /locus_tag="ctg5_2"
                     /transl_table=11
                     /translation="LKYAFAYKNHNIETIFCGKDELFEELKQFLITQCGLIIVEVSRAD
                     YYTEQEMNQWNDRYTL"
     CDS             1029..1169
                     /locus_tag="ctg5_3"
                     /transl_table=11
                     /translation="MPDNILFMTSLISYEIRTVYAYVCIKSLFNRTEYLTSMPEGQRKI
                     A"
     CDS             1845..3569
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg5_4"
                     /sec_met_domain="TPP_enzyme_C (E-value: 2.8e-55, bitscore:
                     180.7, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGTNVQADSLSADCTKTMNGALMLIESLKKENVEMIFGYPGGAVL
                     PIYDKLYQSGLVHILPRHEQGAIHAAEGYARVSGKPGVVIATSGPGATNLVTGLADAMI
                     DSLPLVVFTGQVATSVIGSDAFQEADILGITMPITKHSYQVRRPEDLPRVIKEAFHIAT
                     TGRPGPVLIDIPKDVAAFEGEFRYDHEISLPGYQPVKEPNYLQIRKLVEAVSSAKKPVI
                     LAGAGVLHGKASEDLKNYAEQQQIPVAHTLLGLGGFPADHPLFLGMAGMHGTYTANMAL
                     YHCDLLISIGARFDDRVTGNLKHFAKSAKVAHIDIDPAEIGKIIETQIPVVGDSKIVLQ
                     ELLKQNGKQGQTEEWKQQLSEWKEEYPLWYTDDREEGLKPQKLIEYIHQFTNGEAIVAT
                     DVGQHQMWAAQFYPFRKADKWVTSGGLGTMGFGLPAAIGAQLADRNATVVAILGDGGFQ
                     MTLQELDVIRQLNLPVKVVILNNECLGMVRQWQEIFYEERYSESKFSAQPDFVKLSEAY
                     GIKGVRISSEEEAEEELKKALSSKEPAVIDVRVAKSEKVFPMIAPGKGLHEMVGVKP"
     CDS             3566..4084
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg5_5"
                     /sec_met_domain="ALS_ss_C (E-value: 1e-30, bitscore: 100.2,
                     seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LKRIITLTVVNRSGVLNRITGLFTKRHYNIESITVGHTETSGVSR
                     ITFVVHVEGENDVEQLTKQLNKQIDVLKVTDITNQSIVQRELALIKVVSAPSARTEING
                     IIEPFRASVVDVSRDSIVVQVTGESNKIEALIELLKPYGIKEIARTGTTAFARGTQQKA
                     SSNKTISIV"
     CDS             4107..5135
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg5_6"
                     /sec_met_domain="IlvN (E-value: 3.9e-78, bitscore: 255.1,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 6.8e-68, bitscore: 221.9,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVKVYYNGDIKENVLAGKKVAIIGYGSQGHAHALNLKESGIDVIV
                     GVRQGKSFTQAQEDGHKVFSVREAAAQADIIMVLLPDEQQQKVYEAEIKDELTAGKSLV
                     FAHGFNVHFHQIVPPADVDVFLVAPKGPGHLVRRTYEQGAGVPALFAIYQDVSGEAKDT
                     ALAYAKGIGGARAGVLETTFKEETETDLFGEQAVLCGGLTALVKAGFETLTEAGYQPEL
                     AYFECLHELKLIVDLMYEEGLAGMRYSISDTAQWGDFVSGPRVVDAKVKESMKQVLTDI
                     QNGTFAKEWIVENQVNRPRFNAINASENEHQIEKVGRQLREMMPFVKQGKKKEAVVSVA
                     QN"
     CDS             5122..6678
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HMGL-like"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg5_7"
                     /sec_met_domain="HMGL-like (E-value: 3.2e-97, bitscore:
                     319.6, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LRKINVFDTTLRDGEQSPGVNLNSREKLAIAKQLERLGVDIIEAG
                     FPASSRGDFLAVQEIARTIKNCSVTGLARSVKGDIDAAWEALKDGVSPRIHIFIATSDI
                     HLKHKLKMTREEVKEKAVEMVKYAKERFPIVQWSAEDACRTELPFLAEIVEKVIDAGAS
                     VINLPDTVGYLTPAEYGNIFKYMKEHVPDISRVKLSAHCHDDLGMAVANSLSAIENGAD
                     QIECAINGIGERAGNAALEEIAVALHVRNDAHQADSSLNLHELKRTSDLVSKLTGMAVP
                     RNKAIVGDNAFAHESGIHQDGFLKEKSTYEIISPELVGVTADALVLGKHSGRHAFKDRL
                     NALGFQFDSEEINKFFTMFKELTEKKKEITDDDLISLILEEKVTDKKIGYEFLSLQVHY
                     GTSQVPTATVSLKNQENEQLIQEAATGAGSVEAVYNTLGRCIDKNIELTDYRIQSNRKG
                     EDALAQVYVRVTVNGKETSGRGIAQDVLEASAKAYLNAVNRQLVLDCNLDGLKRRTAVG
                     S"
     CDS             6699..7796
                     /locus_tag="ctg5_8"
                     /transl_table=11
                     /translation="LKKRIALLPGDGIGPEVAESAADVLKSVAEQFGHEFEFENGLIGG
                     AAIDAHQNPLPEETVALCERSDAILLGAVGGPKWDQNPPELRPEKGLLGIRKKLGLFAN
                     LRPVTVFESLSEASPLKKEYISGVDFVIVRELTGGLYFGEPSRQYVNEAGEKEAVDTLF
                     YKKEEIARVVREAFKMAAGRKGKVTSVDKANVLSSSRLWRETADEIAKEFPDVTLEHML
                     VDNAAMQLIYAPSQFDVIVTENMFGDILSDEASMLTGSLGMLPSASLSSSGLHLFEPVH
                     GSAPDIAGKGMANPFAAILSAAMLLRTSFGLENEAQAVEKAVAKVLADGSRTRDIARDG
                     QYAGTHDITEKVKAALAGSNTKSIV"
     CDS             7847..9265
                     /locus_tag="ctg5_9"
                     /transl_table=11
                     /translation="MMPRTIIEKIWDRHVVKSGEGKPDLLYIDLHLIHEVTSPQAFEGL
                     RQKGRKVRRPQNTFATMDHNIPTVNRFDIKDEVAKRQVTALERNCEEFGVRLADLHSAD
                     QGIVHVVGPELGLTLPGKTIVCGDSHTSTHGAFGALAFGIGTSEVEHVLSTQTLWQQRP
                     KTLEIRVDGTLQKGVTAKDVILSVIGKYGVKFGTGYVIEYTGEVFRNMSMDERMTVCNM
                     SIEAGARAGLIAPDDTTIEYCKNRKYAPKGEEFEKAAAEWKALKTDPGAVYDHSIVLDG
                     SEISPMVTWGVNPGMVLPVDAQIPAPETIDSEDGKKEAIRAYEYMGIAPNQKIEDIKVE
                     HVFIGSCTNSRMTDLRQAADMIKGRKVADSVRAIVVPGSQSVKQQAEEEGLHRVFLEAG
                     FEWRESGCSMCLSMNNDVVPEGERCASTSNRNFEGRQGKGARTHLVSPAMAAMAAIHGH
                     FVDVRKFYQEKTVV"
     CDS             9281..9880
                     /locus_tag="ctg5_10"
                     /transl_table=11
                     /translation="MEPLKTHKGKAAVLNRINVDTDQIIPKQFLKRIERTGYGRFAFFD
                     WRYLENGEPDPEFELNRKVYEGASILIAGENFGCGSSREHAPWALDDYGFKIIIAPSFA
                     DIFHQNCFKNGMLPIRMPYDQWKKLAGQYENQSLNMTVDLENQLIHDSEGKEISFEVDP
                     HWKEMLINGYDEISLTLLLEDDIQQFESKRSSWLQA"
     CDS             9999..11003
                     /locus_tag="ctg5_11"
                     /transl_table=11
                     /translation="MTHDKKKADIIPFPRLKERLVDKGMAAMKDKQYEEALELFSEAVS
                     HGDTESDVHLGMAICFLELGELEEAKQVCEKMLNEGYGHYFTVLQVYMTILIQLKQYEE
                     VKSTIEAVLEENQLPAESAEQFYRLLEFSRKMTDPDQQEEAWEEEYEDILDTEKVLNSP
                     AEQMNLIHSLKDRNIAKYTGLLKTILQDPGAHPLIKTMILTLMAEHDYSKPVHITKFGD
                     SMTAIPSETVQPDAAPILHRVLRVLDETLGNENPTLYAAVEELWRRHLYVLHPFMPKFL
                     NADLWAAALHKVGYEMHGIDIEPEELHMMYEFDSRELEEACTMIKDIEEISYL"
     CDS             11220..12494
                     /locus_tag="ctg5_12"
                     /transl_table=11
                     /translation="MSVKWEKQEGNEGVLTVEVDADTFKTALDDAFKKVVKQVSIPGFR
                     KGKVPRGLFEQRFGVEALYQDALDILLPVEYPKAVEEAGIEPVDRPEIDVEKIEKGESL
                     IFTAKVTVKPEVKLGDYKGLGIEKDDTAVTDEDVQNELKALQERQAELVVKEEGAVENG
                     DTVVLDFEGFVDGEAFEGGKAENYSLEVGSGSFIPGFEEQLTGLEAGAEKDVEVTFPEE
                     YHAEELAGKPAVFKVKIHEIKAKELPELNDEFAKDIDEEVETLAELTEKTKKRLEEAKE
                     NEADAKLREELVLKASENAEADVPQAMIDTELDRMLKEFEQRLQMQGMNLELYTQFSGQ
                     DENALKEQMKEDAAKRVKSNLTLEAIAQAENLEVTDEEVEAELTKMAEAYNMPVENIKQ
                     AIGSTDAMKEDLKVRKAIDFLVENR"
     CDS             12766..14028
                     /locus_tag="ctg5_13"
                     /transl_table=11
                     /translation="MFKFNEEKGQLKCSFCGKTQDQVRKLVAGPGVYICDECIELCTEI
                     VEEELGTEEEVEFKDVPKPQEIREILNEYVIGQDQAKKSLAVAVYNHYKRINSNSKVDD
                     VELSKSNISLIGPTGSGKTLLAQTLARILNVPFAIADATSLTEAGYVGEDVENILLKLI
                     QAADYDVEKAEKGIIYIDEIDKVARKSENPSITRDVSGEGVQQALLKILEGTVASVPPQ
                     GGRKHPHQEFIQIDTTNILFICGGAFDGIEQIIKRRLGQKVIGFGSDNKAADLEKEELL
                     SKVLPEDLLRFGLIPEFIGRLPVIASLEQLDETALVEILTKPKNALVKQYKKMLELDDV
                     ELEFEGEALSEIAKKAIERKTGARGLRSIIEGIMLDVMFDLPSRDDIEKCVITGATVAD
                     GEAPRLVLKDGTVVGQDKTSA"
ORIGIN
        1 tcgatgtgtg tccccagctt tataccacct gacccatgtc tgcacctgcg tcttattctt
       61 tatattcaat tcctgcagga tctctttcat aggtacgcct gccaatctca tttctacagc
      121 cttctgtttc acttcaaccg gataactcac tcttgtcccc atagaaaaaa cacctccaag
      181 tctaatttcg gataacaatc atccgtattc aaacttgaag gtgtttttat ttgtctcata
      241 ttatggggtc agtcccatgg gcttgaggtt tttttgtatt ttattgtacg aaacaaaagt
      301 cccgtatttg atgaaaattg taaagtaatt ttaatgtaaa tgaaacttaa tgtaatattt
      361 accgtaataa atatatgtat aaagatactt aaggcgccct tgagtgataa attatctgat
      421 ttctatcata cgttttgttg atgattgata gaaagacagc aggaggaatt agcttttgaa
      481 gtacgcattt gcatataaaa atcacaatat agaaacgatc ttttgcggaa aagacgagct
      541 gtttgaggaa ctgaaacaat ttttaatcac tcaatgcggt ttaatcattg ttgaggtttc
      601 aagggctgat tactatacgg agcaggaaat gaatcagtgg aatgaccgtt atactctgtg
      661 aataagaaaa gaaaccggcc gtgtgagacc ggtttttgta tcatctgaat ccgctcggag
      721 cgctgaagcc cccggcatgg ccgctgaaac cgcccccgag cgcgccggga tgtgccccgg
      781 cgccgaggct tccgccgacg tcactgaagg tttggccgta gtacccggat gtataagggt
      841 acggaacgaa ttgctgtccg gcgaatgaca gtgtgctttg cggggtctgc tgtccgtatc
      901 cggatggcgg aaatccctgc tgaaaagaag ggccgccttg atatggtgct gtatgcatcg
      961 gggccggagg atagtaagac tgcggcggta agaccggtaa aggcggaaat ccaggaggca
     1021 ggccctgcat gcctgataac atcttattca tgacatcact catttcttac gagataagaa
     1081 cagtgtatgc gtatgtctgt ataaagagcc tgttcaatcg aacggaatat ctgacaagca
     1141 tgccggaagg acagagaaaa atcgcgtaat aaaatgtgac atattcgtat atgaacggaa
     1201 aaatttcatg taatcttgag agattaataa aaaaaatata aaaactttta acatttgccg
     1261 atccttttat atcagtaatg aaagcgtata caaaatagat tgattaatct aaattgtcta
     1321 ataattataa aaatgctgtt gacactgtct gcaaacgggc gtaatatgag ttcaaacaaa
     1381 aataaataaa tgattcacgc taaaaagaaa aatcataaaa cactgaaaaa acaaacaaat
     1441 gaaggttctt ttttaataaa agagctgcca taataaaaag cgcagaagag gataagtagc
     1501 tttgctgaag tttttcacag agagccggta acgctgagag ccggtaaaac aaatcaaagt
     1561 gaactcccct cagagtgccg gtctgaaatg taaagagtag gactcggccg agtgaacgca
     1621 atgtttactc gttatcaaaa cggataatca ttatccatga gacggtctgc atatgaccgt
     1681 aaacaagggt ggtaccgcgg agagcaaagc cttttcgccc cttttggcta tcgcatgaaa
     1741 tgcttggctg aatgtgggtg ggaaggcttt tttatttgcg tcagccggcg ctgcgtttta
     1801 tgaattggat tttagaaggg aacattgaaa aggaggaact gaaaatgggc acaaatgtac
     1861 aggcggattc tttgtctgcc gattgtacaa aaacaatgaa cggggctctg atgctgattg
     1921 aatcattaaa gaaagaaaat gtcgagatga tcttcggcta tccgggggga gccgtccttc
     1981 cgatttacga taaactttat caatcaggat tggttcacat cctgccccgc cacgagcaag
     2041 gcgcgattca tgcggcagaa gggtatgcga gagtctccgg aaagccgggg gttgtgattg
     2101 ctacctccgg acccggagcg acaaatttag ttaccggtct tgcggatgcg atgattgatt
     2161 cactgccgct cgtagtgttt accggtcagg tcgccacttc ggtcatcggc agcgacgctt
     2221 tccaggaagc cgacatttta ggaattacga tgccgattac gaaacacagc taccaagtcc
     2281 gccgtccgga agatctcccc cgtgtgatta aagaggcgtt ccatatcgcc acgacgggaa
     2341 gaccgggccc ggtattaatt gatataccga aggatgtcgc agcatttgaa ggagaattca
     2401 gatatgatca cgagatcagc cttccgggtt atcagccggt aaaagagcct aactatctgc
     2461 agatccgaaa gctcgtggaa gctgtcagca gtgcgaaaaa gccggttatt ttagccggag
     2521 cgggtgtttt gcacggtaaa gcttcagaag atttaaaaaa ttatgccgaa cagcagcaaa
     2581 ttccggtagc gcacacgctt ctcggtttgg gcggtttccc ggcagaccat cctctttttc
     2641 tgggaatggc ggggatgcac ggcacataca cagcgaatat ggcgctttac cactgtgact
     2701 tgctgatcag catcggagcg cggttcgatg atcgcgtgac cggaaatctg aagcattttg
     2761 caaaatcggc caaagtagcg catatcgata ttgatcctgc tgaaatcgga aaaattattg
     2821 aaacgcagat tccggtggtc ggcgacagta aaatcgtcct tcaggaatta ttgaagcaaa
     2881 acggaaaaca gggacagaca gaggaatgga aacagcagct ttcagaatgg aaagaagagt
     2941 atccgctttg gtatacagac gacagagaag agggcttgaa accccaaaag ctgattgagt
     3001 atattcacca attcacaaac ggtgaggcga ttgtggcgac ggatgtcggc cagcaccaga
     3061 tgtgggcggc tcagttttat cctttccgaa aggctgataa gtgggtgacc tcgggggggc
     3121 tcggcacaat gggcttcggc cttccggcgg ccatcggagc gcagctggcc gatcgtaacg
     3181 ccacggtcgt tgccatcctc ggagacggcg gttttcagat gacccttcag gaattagatg
     3241 tcatccggca gctgaacctt cctgtcaaag tggttatctt gaacaacgaa tgtctgggca
     3301 tggtcagaca gtggcaggaa atcttctatg aagaacgcta ttctgaatcc aaattctcgg
     3361 cgcagcctga ctttgtcaaa ttgtcagaag cctacggcat taaaggcgtc cggatttcat
     3421 cggaagaaga ggcggaagaa gagcttaaaa aggcgctttc atcaaaagaa ccggccgtta
     3481 ttgacgtccg ggtcgccaaa agcgagaaag tattcccgat gattgcgccg ggtaaaggac
     3541 ttcatgaaat ggtgggggtg aaaccttgaa acgcattatc acattaacgg tggtcaaccg
     3601 ctcgggggta ttaaaccgga tcaccggcct gtttaccaaa agacactata atatcgaaag
     3661 catcactgta ggccacaccg aaacaagcgg tgtttcaagg attacatttg tcgtccatgt
     3721 ggaaggcgaa aatgacgtag agcagctgac aaagcagctt aacaaacaaa ttgacgtcct
     3781 gaaagtgacg gatattacaa atcaatcgat tgtacagcgt gagctggcat taatcaaagt
     3841 tgtttccgca ccgtcggcca gaacggaaat caatggaatc attgagccgt tcagagcttc
     3901 cgtcgttgat gtctcaagag acagcatcgt cgttcaggtt accggcgaat ctaataaaat
     3961 cgaagcgctc atagagcttc tcaaacctta cggaattaaa gaaatcgcga gaacgggcac
     4021 aacggctttt gcgaggggaa cccagcagaa ggcgtcatcc aataaaacaa tttcaattgt
     4081 ataacacaaa aaagggagag attaaaatgg taaaagtata ttataacggt gatatcaaag
     4141 agaacgtatt ggcaggtaaa aaagtagcga ttatcggtta cggttcacaa ggtcatgcac
     4201 acgcgctgaa cttaaaagaa agcggaattg atgtcattgt cggcgtcaga caaggtaaat
     4261 catttacaca ggcccaagaa gacggtcata aagtcttttc ggtaagagaa gcggctgccc
     4321 aggctgatat cattatggtt cttcttccgg atgagcagca gcaaaaagta tatgaagctg
     4381 aaatcaaaga tgaattgacg gcgggcaagt cattggtatt cgcacacgga tttaacgtcc
     4441 atttccatca gatcgtgcct cctgctgatg tggatgtatt ccttgtcgcc cctaaaggac
     4501 ctggacacct tgtcagaaga acatatgaac aaggcgcggg cgtaccggca ttgtttgcca
     4561 tctaccagga tgtatcaggc gaagcgaaag atacggctct tgcttatgca aaaggaatcg
     4621 gcggagcgcg tgcgggggtt cttgaaacaa catttaagga agaaacggaa acggatttgt
     4681 tcggtgagca ggctgttctg tgcggaggtt taacggcgct tgtcaaagcg ggttttgaaa
     4741 cgctgacaga agccggctac cagcctgaac tcgcatactt cgagtgtctg cacgaactga
     4801 agctgatcgt agacttgatg tatgaagaag gattggcggg catgagatac tctatttccg
     4861 atacggctca atggggagac tttgtatcag gaccgcgcgt agtcgatgcg aaggtaaaag
     4921 aatcgatgaa acaagtatta acggatattc aaaacggtac attcgcaaaa gaatggatcg
     4981 tggaaaacca agtgaaccgt cctcgtttca atgcgatcaa tgcaagcgaa aacgagcatc
     5041 agattgaaaa ggtcggcaga cagcttcgtg aaatgatgcc gtttgtcaaa caaggcaaaa
     5101 agaaggaagc ggtggtctcc gttgcgcaaa attaatgttt tcgacacgac ccttcgtgac
     5161 ggtgaacaat ctcccggggt caacctcaat tcccgggaga aactggcgat agccaagcag
     5221 cttgaaagac tcggggtgga cattattgaa gcgggatttc ccgcttcatc ccgaggtgat
     5281 tttttagccg tgcaggaaat cgcaagaacg attaaaaatt gttcggtaac agggcttgcc
     5341 cgatctgtca aaggtgacat tgacgcagcc tgggaagcgc tgaaagacgg ggtcagcccg
     5401 cgcattcaca tctttatcgc cacctctgac attcatctga agcataagct gaaaatgacg
     5461 cgggaagagg ttaaggaaaa agcggttgaa atggtgaagt atgcaaaaga acgctttccg
     5521 atcgttcaat ggtcggcaga agacgcatgc cgcaccgaac ttccgtttct ggctgaaatc
     5581 gtagaaaaag tgattgatgc cggcgcgagc gtcatcaacc tgccggacac tgtaggttac
     5641 ctgacgcctg ctgaatacgg aaacatcttt aaatatatga aggaacacgt tccggatatc
     5701 agccgggtaa agctctctgc ccattgccac gatgatctcg gaatggcggt tgccaactca
     5761 ctttcggcaa ttgagaacgg cgctgatcaa attgaatgcg ccattaacgg cataggagaa
     5821 agagccggga acgccgcgct agaggaaatc gccgttgcgc ttcatgtcag aaatgacgcg
     5881 catcaagccg attcatctct caatcttcat gaattgaagc ggacgagtga tcttgtcagc
     5941 aaactgacgg gcatggccgt tccccgcaac aaagcaatcg tcggagataa cgctttcgca
     6001 catgaatccg gcattcacca agacggtttc ctgaaagaaa aatcaacata tgaaatcatt
     6061 tcaccggaac ttgtcggcgt gactgctgat gcgctcgtac tcggaaagca ttccggacgc
     6121 catgcgttca aagaccgcct gaatgcgctt ggattccagt ttgatagtga ggaaatcaat
     6181 aaatttttta cgatgtttaa agaactgacc gaaaagaaaa aagaaatcac cgatgatgac
     6241 ttgatttctc ttattttaga agaaaaagtg acggacaaaa aaatcggcta tgaatttctg
     6301 tctctgcaag tgcattacgg aacgtctcag gtgccgactg caacagtctc tttgaaaaat
     6361 caggaaaacg aacagctgat tcaagaggcg gcaacggggg cgggcagcgt agaagccgtt
     6421 tataatacgc tcgggcgctg catcgataaa aatattgaac tgacagacta ccgcatccaa
     6481 tccaaccgga aaggcgaaga cgcgctggct caagtttatg tcagagtgac cgtgaacgga
     6541 aaagaaacat cagggcgggg aatcgcgcag gatgttctgg aagcttctgc taaagcttat
     6601 ctgaacgccg tgaaccggca gttggtgctg gattgcaatt tagacggatt aaagagacgg
     6661 actgcggtcg gctcgtaata gaaaggagaa cgtttgattt gaaaaaacgc attgctttgc
     6721 ttccaggtga cggaatcgga ccggaagtgg cggaatcagc ggcagatgta ttgaaaagcg
     6781 ttgctgaaca attcggacat gaatttgaat ttgaaaacgg gctgatcggg ggagcagcga
     6841 ttgacgccca tcaaaacccc cttcctgagg agacggtggc tctttgtgaa agatccgacg
     6901 ccatcctgct cggggcagtc ggcggaccga aatgggacca aaaccctccg gagctcagac
     6961 cggaaaaagg cctgctcggc atcagaaaaa agctcggcct gtttgccaat ctgcgtcctg
     7021 tgaccgtatt tgaaagcctg tctgaggcgt ctccgctgaa aaaagaatat atcagcggcg
     7081 tcgactttgt aatcgtcagg gaactgacgg gcggcctcta cttcggagaa ccgagcagac
     7141 agtatgtcaa tgaagcggga gaaaaggaag cggtcgatac ccttttttat aagaaagaag
     7201 aaatcgcacg cgttgtcaga gaagccttta agatggctgc cggcagaaaa ggaaaagtga
     7261 cgtccgttga taaggcgaat gtgctttctt caagcagact gtggcgtgaa acggcagatg
     7321 aaatcgcaaa agaatttcct gatgtgacgc ttgaacatat gcttgtcgat aatgccgcga
     7381 tgcagctcat ctacgctccg agccagtttg acgtcatcgt aactgaaaat atgttcggcg
     7441 atattttaag cgatgaagcc tccatgctga caggctcgct cggcatgctg ccgtcagcca
     7501 gtttatcaag ttcaggtctt cacttgtttg aacccgtgca tggatctgcg cctgacatcg
     7561 ccggtaaagg gatggccaat ccgtttgcgg cgattttatc agcggcgatg cttttgagaa
     7621 catctttcgg acttgaaaac gaagcgcagg cggtggaaaa ggcggtcgca aaggtgcttg
     7681 cagacggcag ccgtacacgt gatatcgccc gggacggcca atatgccgga acgcatgaca
     7741 ttactgaaaa agtaaaagcc gcattagccg gctcgaatac aaaatctata gtatgacgct
     7801 ttaaagaaag cggtcttagt tcaataggta gagggaggaa acaaagatga tgcctcgaac
     7861 aatcatcgaa aagatttggg atcggcatgt tgtaaaaagc ggtgaaggaa aacccgacct
     7921 tctctatatt gatctgcacc tcattcatga ggtgacgtct cctcaggcgt ttgaagggtt
     7981 aaggcagaag ggaagaaagg tcagacggcc gcagaacaca ttcgcgacga tggaccacaa
     8041 tattccgacc gtcaaccgtt ttgacattaa agatgaagtc gcaaagcgcc aagtaaccgc
     8101 gcttgaacga aattgcgagg agttcggcgt ccgtcttgcg gatcttcaca gcgcagacca
     8161 gggaatcgtt cacgtggtcg ggcctgagct tggtctgaca cttccgggaa aaacgatcgt
     8221 ttgcggagac agccatacat cgactcacgg cgcgttcgga gcgcttgcct tcggtatcgg
     8281 cacaagtgag gtggaacatg ttctttccac acagacatta tggcagcagc ggccgaaaac
     8341 gcttgaaatc cgcgttgacg gaacgctcca aaaaggagtg acagcgaagg atgtcatctt
     8401 gtcggtcatc ggaaaatacg gggtgaaatt cggtaccgga tatgtcattg aatacaccgg
     8461 ggaagtattc agaaacatgt ctatggacga acgcatgact gtctgcaata tgtcaataga
     8521 agcgggagcc cgtgcgggac tgatcgctcc tgatgacacg acgattgaat actgtaaaaa
     8581 ccgtaaatac gcgccaaaag gcgaggaatt tgaaaaagcc gccgcagaat ggaaagcgtt
     8641 aaaaaccgat ccgggcgccg tatacgatca ttccatcgtg ttagacggca gcgagatttc
     8701 tccaatggta acatggggtg tcaatcccgg catggttctt ccggtcgatg cccaaatacc
     8761 tgcgccggaa acgattgatt ctgaagacgg taaaaaagaa gccatccgcg cttacgaata
     8821 catggggatc gcgccgaatc aaaaaattga agatattaaa gtagagcatg tgtttatcgg
     8881 ctcctgtaca aattcacgga tgaccgatct tcgccaggct gcggatatga tcaaaggccg
     8941 aaaagtcgcc gacagcgtca gagccattgt ggtgccgggt tctcaaagcg tgaaacagca
     9001 ggccgaagaa gaagggctgc accgcgtgtt tctcgaggcc ggctttgaat ggagggaatc
     9061 aggctgcagc atgtgcctca gtatgaacaa tgatgtcgtg cctgaagggg aacgatgcgc
     9121 ttccacttcc aaccgcaact tcgaaggcag acagggaaaa ggcgcgagaa cacaccttgt
     9181 cagtccggcg atggcggcaa tggcggccat tcacgggcat ttcgtcgatg taagaaagtt
     9241 ttatcaagaa aaaacagttg tgtaaggagt gcgcgaaaag atggaacctt taaaaacgca
     9301 taagggaaaa gcggccgtct taaaccggat caacgtcgat acggaccaga ttattccgaa
     9361 acagtttttg aaaagaattg aaagaaccgg atacggcaga ttcgcgtttt ttgattggag
     9421 ataccttgag aacggtgagc ctgatcctga atttgaatta aaccgcaaag tctatgaagg
     9481 cgcgtccata ttaattgccg gagagaattt cggctgcgga tcatcccgtg agcacgctcc
     9541 ttgggcgctg gatgattacg gcttcaaaat catcattgct ccgtcatttg ccgatatttt
     9601 tcatcagaac tgttttaaaa acggtatgct tcccatccgt atgccgtatg atcagtggaa
     9661 aaaactcgcc ggtcaatatg aaaatcagtc tctaaatatg acggttgatt tggaaaacca
     9721 gctcattcac gacagtgaag gaaaagagat ttcatttgaa gtcgatccgc actggaagga
     9781 aatgctgatt aacggttatg atgaaatttc attaacgctt ctgctggagg acgacattca
     9841 gcagtttgaa tcgaaaagaa gttcatggct tcaagcctga aaaaagccgc ccggcatctg
     9901 tccggcggct ttttttaccg tgtgcatcat cctttcttgt gtttcatgac gcgtgttgat
     9961 acacttgaac aaaataagcg cctgaaagga aataaagtat gacgcatgac aagaaaaaag
    10021 ctgatatcat tcctttcccc cgtctgaaag aacgcttggt tgataaaggg atggccgcca
    10081 tgaaggataa acagtatgag gaggccctcg aactgttttc agaggcggta agccacggcg
    10141 ataccgagtc cgacgtacat ttaggcatgg cgatttgttt tctggaactc ggggaattgg
    10201 aagaagcaaa acaagtttgc gagaaaatgc tgaatgaagg gtacggccat tatttcaccg
    10261 tattgcaggt gtacatgacc attttaattc agctgaaaca atatgaagaa gtcaaaagca
    10321 caattgaagc tgtgctggaa gaaaaccagc tgcccgcaga aagtgcggag caattctacc
    10381 ggctgctcga attcagccgc aaaatgaccg atcccgatca gcaggaggag gcgtgggagg
    10441 aggaatacga ggacattctt gatacggaaa aagtgctgaa cagccccgct gaacaaatga
    10501 atctgattca ttctcttaaa gaccgcaata ttgcaaaata cacgggtctc ttaaaaacga
    10561 ttcttcaaga tccgggcgcg catcctctta ttaagacaat gattttgacg ctgatggccg
    10621 agcacgacta cagtaaaccg gtccatatta caaaattcgg cgattcaatg accgcgatac
    10681 cgagtgaaac ggtccagcct gatgcggctc cgattttgca tcgcgttctc cgggtgcttg
    10741 atgaaacgct gggcaatgaa aaccctacat tatatgctgc cgtcgaggag ctgtggagaa
    10801 gacatctgta cgtcctgcac ccttttatgc cgaagttttt gaacgcggat ttatgggcgg
    10861 cggcgcttca taaggtcggt tacgagatgc acggcattga cattgagccg gaggaacttc
    10921 atatgatgta cgagtttgac agccgcgaac tcgaagaagc ctgcacgatg attaaggata
    10981 ttgaagaaat ttcttatttg taaatcacac catatagttg aaagcggtag gcgttatgtt
    11041 ataatatagt ggttgtattt atgtatagcg gtttaactga aatgagaatt acggttggac
    11101 aggctgccag ttcattacat aatgattctg attcaaagcg gttttttctt tgacaaagcc
    11161 gcggattgct ttagaatgga agaccgacac aacctgaata gatttttgga gggaaacaca
    11221 tgtctgtaaa atgggaaaaa caagaaggca acgaaggcgt attaacggtt gaagttgatg
    11281 cggatacgtt caaaacagct cttgatgatg catttaaaaa agtagtaaaa caggtttcta
    11341 ttcctggatt ccgcaaaggg aaagttcccc gcggtttatt cgaacagcgt ttcggcgttg
    11401 aagctcttta ccaggatgct ttagatattt tacttcctgt agaataccct aaagcggttg
    11461 aagaagccgg cattgagcct gtagaccgcc ctgaaatcga tgttgaaaaa atcgaaaaag
    11521 gcgaaagctt aattttcact gcaaaagtga ctgtaaaacc ggaagtgaaa cttggcgatt
    11581 acaaaggctt aggaatcgaa aaagatgaca ctgccgttac tgacgaagat gtacaaaacg
    11641 aacttaaagc gcttcaagag cgtcaggctg agcttgtcgt gaaagaagaa ggcgctgttg
    11701 aaaacggcga tacagtcgtt cttgacttcg aaggtttcgt tgacggcgaa gcgtttgaag
    11761 gcggaaaagc tgagaactac tcacttgaag taggatcagg ttcattcatc ccgggcttcg
    11821 aagagcagtt aacaggcctt gaagcaggcg ctgaaaagga tgttgaagta acattccctg
    11881 aagagtacca cgctgaagag cttgccggaa aaccagctgt tttcaaagtg aaaattcatg
    11941 aaatcaaagc gaaagagctt cctgagctta acgacgaatt cgcaaaagac attgacgaag
    12001 aagttgaaac gcttgctgaa ttaaccgaga aaacaaaaaa acgccttgaa gaagcaaaag
    12061 aaaacgaagc tgacgctaaa ttgcgtgaag agcttgttct gaaagcatct gaaaacgctg
    12121 aagctgatgt tcctcaagcg atgatcgaca ctgagcttga ccgcatgctg aaagaattcg
    12181 aacagcgtct gcaaatgcaa ggcatgaacc ttgagcttta cactcaattc tcaggccaag
    12241 acgaaaacgc gttaaaagag caaatgaaag aagatgccgc aaaacgcgta aaatcaaacc
    12301 tgactcttga agcgatcgct caagcagaaa accttgaagt aacggacgaa gaagttgaag
    12361 cagagctgac taaaatggct gaagcttaca acatgccggt tgaaaacatc aagcaggcaa
    12421 tcggttcaac tgacgcgatg aaagaagatt taaaagttcg aaaagcaatt gattttcttg
    12481 tagaaaaccg ttaatatggt tcataataat agacataata aaacagggcg cgattaattc
    12541 gtgccttgtt ttgtacaatt atgatataac tctttttctt ggggcaagat agtcattgcc
    12601 gggctgtttt tcgtcataca tatagaatgt gcaagtgcga aacacattgt taccgtctta
    12661 ctggaaagta tggtaaaatg caatacatac tcgatcgtag caagaaccgt tttcttttgc
    12721 ccttcaggta aaagaaaaag tgagacaaga ttaaggggtg aaagaatgtt taaattcaac
    12781 gaggaaaaag gacaattgaa atgctcgttc tgcggaaaaa cgcaagatca ggttcgtaag
    12841 ctggttgcag gaccgggtgt atatatatgc gacgaatgta ttgagctctg tacagaaatc
    12901 gtagaggaag agcttggtac ggaagaagaa gtcgaattta aagacgttcc gaagccgcag
    12961 gaaatccgtg agattctgaa tgaatatgtc atcggacagg atcaggcgaa gaaatcactt
    13021 gcggttgcgg tatacaacca ttacaaacgc atcaattcca acagtaaagt ggatgatgtt
    13081 gagctttcta aaagtaatat ttctttaatc ggaccgactg gaagcgggaa aacacttctt
    13141 gcccagacgc ttgcgcgtat tctgaacgtt ccgtttgcga tcgcggacgc tacatctctg
    13201 actgaagccg gatatgtcgg tgaggacgta gaaaacatcc tcctcaagct gattcaggca
    13261 gcagactatg atgtggaaaa agcagaaaaa ggcattatct atatcgatga aatcgataaa
    13321 gtagcgcgaa aatctgaaaa cccgtccatt acacgcgatg tatcaggcga aggcgttcag
    13381 caggcgctgc tgaaaattct tgaaggaacg gttgcaagcg tgccgcctca aggaggacgc
    13441 aaacatcctc atcaggaatt catccagatc gatacgacga acattctgtt catttgcggc
    13501 ggtgcatttg atggcatcga acaaatcatc aaacgccgtc tcggacaaaa agtcatcggc
    13561 ttcggctctg ataataaagc ggcagacctg gaaaaagaag aactgctttc taaagttctt
    13621 ccggaagacc tgctccgttt cggtctgatt cctgaattca tcggccgtct tcctgtcatt
    13681 gcaagccttg agcagcttga cgaaacggca ctggttgaaa ttctgactaa accgaaaaac
    13741 gcactcgtca aacaatacaa gaaaatgtta gaacttgatg atgtcgagct tgaatttgaa
    13801 ggcgaggcat tatctgaaat tgcgaaaaaa gcgatcgagc gtaaaacagg cgcacgcggc
    13861 ctgcgttcta tcattgaagg catcatgctt gacgtcatgt ttgatctgcc gtcccgcgat
    13921 gatattgaaa aatgtgtcat taccggagcg acagtcgcag acggtgaagc gccgcgtctt
    13981 gtattaaaag acggcactgt tgtcggccaa gataaaacat cagcataaca cgacaaaacc
    14041 tcctgacccg aattaatcag gaggtttttt tcttgtcctg acccttctga aaatgtttat
    14101 tccgggcttt gctgggagat actagcggac agaggaatga attggataca taaatcgttt
    14161 tttcaggagg gaccagcatg agttggacag ggatcgcatt atttgtacag ctgtttttcg
    14221 ggatagtcat cggactatat ttttggaatc tgctcaaaaa ccagcgaaca caaaaagtga
    14281 cgatagataa agaatcaaaa aaggaaatgg aacagctgcg caaaatgcgc gccatcagtt
    14341 tatcagaacc tttatcagaa aaggtgcggc cgaaaagctt tcaggacatt gtcggccagg
    14401 aagacggaat taaagcgtta aaagcagcgc tttgcggacc gaacccgcag cacgtcatta
    14461 tttacggtcc tccgggagtc ggtaaaacgg ctgcggcgcg gttggtattg gaagaagcga
    14521 aaaagcataa acagtcaccg tttcaaaagc aggctgtttt tgttgaactt gatgcgacga
    14581 ccgcgcgatt tgatgaacgg gggattgccg atccgcttat cggttcagtg catgatccga
    14641 tttatcaggg agcgggtgcg atgggccaag caggcattcc gcagccgaaa cagggggctg
    14701 tgacccatgc tcacggcggg gtattgttta ttgatgaaat cggcgagctt cacccgattc
    14761 agatgaataa aatgctgaag gtgcttgaag accgaaaagt atttttagac agtgcgtatt
    14821 acagtgaaga aaatacgcaa ataccgaatc acatccatga tatttttcaa aatgggcttc
    14881 cggcggattt ccgtttgatc ggagcgacaa cgagaatgcc gactgaaatt cctccggcca
    14941 tccgttcgcg ctgtcttgaa gtatttttcc gcgagctgga aaaggatgaa cttaaaatcg
    15001 ttgcgaaaaa agcagccgac aaaattcaga aagagatttc tgacgaagct ctcagcgtgc
    15061 tgaccgcata tacgagaaac ggacgtgaag ccgtcaatat gatccagatc gctgccggca
    15121 tggcggtgac tgagg
//
