LOCUS       gnlProkkaHDCEGNDM_1    15721 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|HDCEGNDM_1.
ACCESSION   gnlProkkaHDCEGNDM_1
VERSION     gnlProkkaHDCEGNDM_1
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2025-04-28 23:18:31
            Original ID  :: gnl|Prokka|HDCEGNDM_1
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15721
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15721
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[2919:5721]"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      2920..5721
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     cand_cluster    1..15721
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..15721
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="lanthipeptide-class-ii"
                     /region_number="1"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     CDS             complement(3..122)
                     /locus_tag="ctg1_1"
                     /transl_table=11
                     /translation="MNEDLVRAKNRLHKVLQVTFPELENLLSTPTGEQYWNLMM"
     CDS             complement(324..1694)
                     /gene_functions="regulatory (smcogs) SMCOG1003:sensor
                     histidine kinase (Score: 118.9; E-value: 5.6e-36)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg1_2"
                     /transl_table=11
                     /translation="MIMNQTKILRYSLKKFIFFSIIIFITNIILIASFVFYIREKQTAT
                     KTVKIISEHITITKNNVHIPKNDISSLKEQKLWLMVLDKQTGKQVYEQYKPTEVPSQFD
                     YGDILQFSRYYLSDYPVFSQIKGGYIIVVGFPKDKIARYSYNYLDIDSIRLIPLIAFGV
                     LLFNCLYFAFLYYYGVTHINRKIAPLVTAIQNLPDGLKNPINSISELEYLTTAINQTDT
                     LLKENEVFKEQWISGIAHDIKTPLSVIISNASLLNDSELDTQSEKHIRPILTESYYIQN
                     ILNDLNIVARLSSGHLQLNQTETKIIPFFKDILIHILNQEVWNDFELEFDYDYSLVNQS
                     IMIEQFLITRVIHNIIYNSVLHNEKGCTIRIHLFKKDTNVIVEIKDNGQGASPEKIAEL
                     NELSFKNIDISKIRTTGIGLKISKQIVDLHQGSISFASVQNEFFESIISLPIFNITN"
     CDS             complement(1691..2389)
                     /gene_functions="regulatory (smcogs) SMCOG1008:response
                     regulator (Score: 175.4; E-value: 2.1e-53)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg1_3"
                     /transl_table=11
                     /translation="MNFEQQLLNKHILIIDDDKILNSSIRDILTAYGFSNLTSAYDIES
                     SLDMIETEQFDLFLLDIMLPDGDGYTLAKHIRKKGDTPILFLTAKNNPEDEVAGFNAGG
                     DDYVMKPFIPKNLIYRIMALLRRSYKSEQEAIQIGQTLVSFRNATVQKNGAEISITPIE
                     IQILKKLYDNKNYIVSTESLCDTIWGVDSFGYENTLTVHIRKIREKIEENPSKPQYLKT
                     AKGLGYKLLS"
     CDS             2570..2740
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) L_biotic_A"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) leader_d"
                     /gene_functions="biosynthetic-additional (lanthipeptides)
                     predicted lanthipeptide"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg1_4"
                     /sec_met_domain="L_biotic_A (E-value: 1e-29, bitscore:
                     95.7, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="leader_d (E-value: 1.2e-06, bitscore:
                     22.0, seeds: 16, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAKQQMNLVEIEAMNSLQELTLEELDNVLGAGGGVIQTISHECRM
                     NSWQFLFTCCS"
     CDS_motif       2570..2662
                     /prepeptide="leader"
                     /note="peptide class: {self.peptide_class}"
                     /note="predicted sequence: MAKQQMNLVEIEAMNSLQELTLEELDNVLGA"
                     /locus_tag="ctg1_4_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       2663..2740
                     /prepeptide="core"
                     /locus_tag="ctg1_4_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="5.20"
                     /molecular_weight="2715.1"
                     /monoisotopic_mass="2713.2"
                     /core_sequence="GGGVIQTISHECRMNSWQFLFTCCS"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MAKQQMNLVEIEAMNSLQELTLEELDNVLGA"
                     /leader_location="[2569:2662](+)"
                     /alternative_weights="2733.1"
                     /alternative_weights="2751.1"
     CDS             2920..5721
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070:lanthionine synthetase C family protein (Score:
                     641.9; E-value: 3e-194)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg1_5"
                     /sec_met_domain="DUF4135 (E-value: 2.8e-80, bitscore:
                     263.6, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 3.9e-52, bitscore:
                     170.5, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MENTEKNKLFNKFTRNFIQTNFSEYDMQNCEIEFLEDKVLDIYMN
                     TLILLINEKRLLGILKGSTSEERYEYFNDVLCGKYIIDEIAKRFPKLVSRSLTQLKNYL
                     LLYRKVEQLFLKDVPKLIQNRFISNQCENFKMEDLQITVSGDFHNGSGVCILFYKGERV
                     IYKGKNNFANQLLIEIFSKLGDEFEESLEFLPRYIDCGDYYWEEYIEHTSIRNSNISAS
                     EYYKRFGYLLAVAYLLNISDLHFENILASGDIPKLVDVETIFNLQPYEILSETIADKDL
                     LKRNAESVLLTGLLPLAGSNEVFGGDTSGILGGKFVGEVRVIQNQMRDDISVKRQVVRK
                     TNKSHLPFYISEGEEQYFEVKDYLRELLFGFKKVTSYVENQKNTFLSIIEKYSEKIDVR
                     ILFRNTKDYSIVRTLLLSPKYSENDNIIFEKFKNKLVNYQSDELCESEIKQLEQMDIPY
                     FSMKSNSCDVYDLYGNAVWSTYYSPIELIRKKIQNLSVHIIEEQYKLIEFSISSTLRLY
                     NQEALPRINDVEDKSYSDSILYKGVQNIVDRLLGAIYLSNSDQTCNWLTLSINNVDCLE
                     LSPMDCTLYGGLSGVALALIESMTLLEEDYRKKVRSVLPYLYNSILKKYEYLTNDSFYM
                     GRMGVLYTLKKLSKEVGKDLDNWVNIEIDNVISRLNIGDTDFLTGISSVIPAIRLENLN
                     KVTFEELSDIYIKQAKEKDNFVFWGNEQSNNVSLAHGNLGIELALVRLIKVLDNSNNKE
                     TISTLLKKAINFDNLQRREHGWVDNRNFSHSANWCHGATGVLLSRIDLYNQLKNDKTAT
                     ISSTDLQQDVIHSLQDIKEVGLNLANFSLCHGVSGNLLTLVHTQNFFDENNIVNNYNLK
                     KFVRENFYKIHLYGLQNGWMCNFNTKYDSYALFTGISGILYATTLYLKNDIKSDVLLPN
                     IVS"
     CDS             5734..7815
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 137.8; E-value:
                     8.2e-42)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_6"
                     /sec_met_domain="Peptidase_C39 (E-value: 5.9e-37, bitscore:
                     119.9, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIILQNNESDCLLACYAMLLNNLGLEIPLYEIYKEDMIPADGLN
                     VSYLIKLNKRFKVGIKAYRILLKDIAVCLEKNIPVILHWNDNHFVVLLKIRNKKYTIID
                     PAIGKITYSEEEVLKHYSGICVTVFKGVEFKRIKYSNLFVEQLRQTIRLKPAMYFILAL
                     GLTQAGVFLFSITIRNILDVKYSFIASLLMLMSVVVVQLISVLIKNETISEFNNDFDEN
                     YVNKLFKMLLNKPLLYFRNMSNGVLGEKINLKSTIRDSITLKLLPSIVGFISLFVVILY
                     LLTISTKLTFILLILLIFYGIVSSVLYKKQNELNHAYLQYLIDFNSVLQTDLENIDFIK
                     IARKEEQIFKSWKSSNNLVTDKYSSILKVENFSQFVGSTFNYISLSLILILGIYFKAYF
                     EVSIPDLILYQTSVSLMISFFEQIKQSIFEIAKLQVYAEKQSDLFTNNASIEIPIDNEQ
                     SSVIRCDKVNFSYNNQKLYSGINLEILKGEKIAILGESGSGKSTLLLLLLGMLRYDGEL
                     TYGVSDFTSRIGVVLQNMTLVPDTILKNLDCAPSDEDLERILRDTGGERVIAKLPNKLF
                     SKVLKSGKNLSGGQIQKLLISRSLLNKRDIIFWDEAFSNLDEKSKKKIYTDVLSNPFYS
                     DKTMVIVSHQLDIVNYVDSIIFVDKSSGDVIKDTHDNLIYRNQNYRKLFGLKEKVHND"
     CDS             7808..8719
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 178.6; E-value:
                     2.6e-54)"
                     /gene_kind="transport"
                     /locus_tag="ctg1_7"
                     /transl_table=11
                     /translation="MISNVLQIKNLQKGFKDTQVVNLSSLSVQQGEIYGFLGPNGAGKT
                     TTMKMILSLISRTAGEIEVFGQSIGTDKQYLNQIGSMIEEPSYYPNLTGYENLLVFQKI
                     LGFDKKNIQETLKIVGLDQPKNKKKLVKDYSLGMKQRLALAFALVKKPRLLILDEPTNG
                     LDPAGIHEIRELIIKLAKEQGITVFISTHILSEVEHIADRVGIINHGQLVYEGEIRKIQ
                     SNKWLEVRGDFRDRREVISQVLFGYPCKMLEIQEDKLKLTNLADQQISSLLRDLIVEKV
                     PIYEVKQEQETLESIFLNLTKE"
     CDS             8725..9474
                     /locus_tag="ctg1_8"
                     /transl_table=11
                     /translation="MLNNLSIELLKAKRTKSFLISILVMGVGFAWAIVAATRYLSNPNI
                     HQISLIFYMIKEVNGLILPIVIALFVSRIVKNEKEGNTFKLLLANGENVRHIFLSKLGL
                     TMFVLAFLAFLEGVVVQLIAILSGLEMPVSLILWQIVIFLLASFVLTCLFLTLQFLLKK
                     QALILALGIFGGFLGVGFGHAPAILQLIFPFGGIGYLSLVDYQQVASQVSYVLVTNLGF
                     KLFTYLPIALIYLFLSLYLVEKKGGKL"
     CDS             9471..10199
                     /locus_tag="ctg1_9"
                     /transl_table=11
                     /translation="MMSYLSVEWRKTKKFSMLMIGICFLAFCSLIGLGIYFGSAYSIVA
                     ESEKVPVLWGQLTFYYSQLFFPILVSLYVAMMLGKEFDRKNIEFLRANNVSLGKLLLAK
                     EIVIILFIAVLQLFLFGIFYVSAHLAHLEISNLFTYLKWDLLGIFGTISMMAVQFFVTA
                     KTRVFSKSVGIGAIGTFVGFMMIFVSDKLSLIYPYSQAMVAMRSRNLIDFNLVEILLFI
                     IVNILLWGIFHTLSNKELHK"
     CDS             complement(10471..11319)
                     /gene_functions="other (smcogs) SMCOG1237:transposase
                     (Score: 166.5; E-value: 1.8e-50)"
                     /gene_kind="other"
                     /locus_tag="ctg1_10"
                     /transl_table=11
                     /translation="MRLQASIIDVFKPFLRTHTRLSPLEAKKQLDSLRVRKTDKIDAEK
                     LAKSQLVHNRKATYVQEEVYQHLRDLRCFYQNMIEDLVRTRNRLHKVLQVTFPELENLL
                     STPTGEQYWNLMMAFPCKEFVLSLSQSDLCEIIRQSTSKHISEKRIAYLTDKLIKLSKQ
                     SFCAIKKTSPMMEEVRYYAQELLRLSERRQVVLNNMVALVQPLPEYDILRSIPGIAETT
                     ATSIIGELGDMRCFQSTNPCHIAAISLTFMRNEKDNTFNKSSCSSFNTSSHSDNVLPYY
                     A"
     CDS             complement(11955..12218)
                     /locus_tag="ctg1_11"
                     /transl_table=11
                     /translation="MLCIRKSHSYIRKNNSNWIELIVKDNFDFTVKLQYSKKMRVSDIN
                     YDIGDNLFIYALIISSEKTINQKKRSYFNLMVEDMINKTNLK"
     CDS             12684..13442
                     /locus_tag="ctg1_12"
                     /transl_table=11
                     /translation="MSYSHLTITDRIKIETYLELGWKPCQIASKLGVHKSTISRELRRC
                     QNGYFAALAQEQYDHRAKQKGRKSCLTPELKKEIEDGLKSSWSPEQICGRYQLEQKPMV
                     AFKTIYNWLYAGLIDLDLSVLRRKGKTRQPKETRGTFRIGTSIAKRPKEVRNRETFGHW
                     ELDTVVSSRGKSKGCLATFLERKTRFYIAFKIPDRTAKSMFSAIRQLCKLFPKEALKTF
                     TSDRGKEFACYPLVENLGIPFFFADAYSSW"
     CDS             13918..14268
                     /locus_tag="ctg1_13"
                     /transl_table=11
                     /translation="MPNYPCEFEVTFLDDYHKKHNYPLFYESYLQNIMEFLESQDIKNG
                     ADAFVDDHQNLVFVLYGQGYRAEGKEGILTTQVTVKAYDEDNKPINLANLLDSLIVSEY
                     QMEANLWEVSHD"
     CDS             14261..14641
                     /locus_tag="ctg1_14"
                     /transl_table=11
                     /translation="MIDLYLSKNSQRNQLLLDFFQKYGIEVTPHSISEMTKDKLIEMMS
                     YSSDCFEYLSPNLLRFKNRDNLRLTDFVEMFLKNPELTIRLPLAVSNKRVYPNLNLEEA
                     RALLPRDTKQLIYIAQTHYLSS"
     CDS             14654..15190
                     /locus_tag="ctg1_15"
                     /transl_table=11
                     /translation="MAERFWENLSIILAERNISWIELTRKMFAGEFHYPSELNRLYQKI
                     VSLHAQSSTKADAMKKLRTKKTLMESQKIGEQQKLARTGIYLEKVGHVLESNIDEAEEL
                     LKTMTETGDKLFQTVFLIGVFGQDEEELKQALDTIQQVAGSNDLMIDKEVKAAKENLRN
                     CSPFMMRFPNYTKQS"
ORIGIN
        1 gccatcatta agttccaata ttgctctcca gtaggtgtgg ataatagatt ctccaattca
       61 ggaaaagtga cttgtagaac cttgtgcaga cggtttttag ctcgaacaag atcttcattc
      121 atattttcgt ggagggctat ggaatatatt tgttctttac agagactgaa ctttacacgg
      181 aagttttggc gcagaatgga ttatttggtt ttacgacttt ctttatcatc tttaaccttg
      241 ctttgcttgt cttggcaggc tgggcagggt ataagatgaa aaaaatggag aaaactctaa
      301 tggttcttct ccattttttt tatctaattg gtaatgttga aaatcggaag tgaaatgata
      361 ctttcaaaga attcattttg gacacttgca aatgaaatag agccctgatg caaatcaaca
      421 atttgttttg aaatttttag cccaattcca gtcgttctaa ttttagaaat atcaatgttt
      481 ttaaaagata attcattaag ttcagcaatt ttttctggtg aagctccctg tccattatct
      541 ttgatttcga caataacatt tgtatctttt ttgaacaagt ggattcttat tgtgcaaccc
      601 ttttcgttat gtaaaacaga gttgtagatg atattatgga taactcttgt gattaaaaac
      661 tgctcaatca tgatagattg attaacaagt gaataatcgt aatcaaattc aagttcaaaa
      721 tcattccaga cttcttgatt taaaatatgg atgagaatgt ctttgaagaa ggggataatt
      781 tttgtttcag tctgatttaa ttgaagatga ccggatgaaa ggcgagctac tatatttaag
      841 tcatttaaaa tattttggat gtaataggat tccgtcaata ttgggcgaat atgtttttca
      901 gactgtgtat ctagttcaga atcatttaac aaggacgcat tagaaatgat gacagaaaga
      961 ggtgttttga tatcgtgtgc aatacctgaa atccattgct ctttaaagac ttcattctct
     1021 ttgagtagag tatcggtttg attaattgca gttgtaagat attctagttc tgatatagaa
     1081 tttattggat ttttcaaacc atctgggaga ttctgaatag cagttacaag aggcgcaatt
     1141 ttacgattga tatgcgtcac accatagtag taaagaaaag cgaaataaag gcagttgaaa
     1201 agcaatactc caaatgctat tagtggaatc aagcgaatac tatctatatc taagtaatta
     1261 taactataac gagcaatttt atcttttgga aaaccaacaa caatgatgta gccacctttt
     1321 atctgactaa aaacaggata atctgaaaga taatagcgag aaaactgtaa aatgtctcca
     1381 tagtcaaatt gcgaaggaac ttctgtaggt ttatactgtt cgtacacttg ttttccagtc
     1441 tgcttatcca ataccatgag ccataacttt tgttctttta gactagaaat atcattttta
     1501 ggtatgtgga cgttattttt tgtgatggta atgtgttcag aaattatttt cacagtctta
     1561 gtagcagttt gcttttccct aatgtagaaa acaaaactgg caattagaat aatattggta
     1621 ataaagataa tgatggaaaa aaagataaat ttctttagtg aataccttaa aattttggtt
     1681 tggttcataa tcatgataac aatttatatc ccagcccttt agctgtcttt aaatattgag
     1741 gttttgaagg attttcttct attttttctc gaattttccg aatatgtaca gttaaagtgt
     1801 tttcataacc aaagctatcc actccccaaa tcgtatcaca gagagattcg gttgaaacga
     1861 tgtaattttt attatcgtaa agttttttca aaatctgaat ttcaattggc gtaatagaaa
     1921 tttctgctcc atttttttgt actgttgcat tccgaaaact caccaaagtc tgtccaatct
     1981 gtattgcttc ctgttctgat ttatagcttc tccggagcag agccataata cgatagataa
     2041 gattttttgg aatgaagggt ttcatgacat aatcatcacc accagcattg aaaccagcta
     2101 cctcatcttc aggattattt ttggcagtca aaaagaggat aggtgtatcg cctttttttc
     2161 ggatatgttt tgctaatgtg tagccatcac catcggggag cataatgtcc aaaaggaaaa
     2221 ggtcgaactg ctctgtttca atcatgtcca aactagattc tatatcatag gctgatgtta
     2281 ggttggaaaa tccgtaggca gtgagaatat ctcttatgga agagtttaaa attttatcgt
     2341 catcaatgat aaggatgtgc ttattcagga gttgttgttc gaaattcata atcttacctc
     2401 gcttatcaat attataccat ttaaaagagt gaaaaaaggc aaaacacttt catcttaatg
     2461 taaaattaag gttagcttag tttaaaatta atctagcatg tctataataa agacataacc
     2521 tagatagaga tacttctcaa ataaatttta atcagtgagg tatttccaaa tggctaaaca
     2581 acaaatgaat ctcgttgaga ttgaagcaat gaattctctt caagaattga ctcttgaaga
     2641 acttgataac gttcttggtg ctggtggtgg agtaatccaa accatttcac acgaatgtcg
     2701 catgaactca tggcagttct tgtttacttg ttgctcttaa ttacgttcta taagcctaaa
     2761 ttttagcacg taatttgact tttaagaatt ttaagggaga tatatttaaa ataatatctt
     2821 ctagaaattc taatagtatc acaatctaac aatgagaggt gtctctactc ttggttttat
     2881 ttatagaaat cttgttcatc atgaaaatag gtggtcaaaa tggaaaatac cgagaaaaat
     2941 aaattattta acaaatttac tagaaatttt atccaaacaa acttctcaga gtatgatatg
     3001 caaaactgtg agatagaatt tttagaagat aaagttttag atatttatat gaatacacta
     3061 atccttttga taaacgaaaa aagattatta ggaattttaa agggttcaac ttcggaagag
     3121 cggtatgaat attttaatga tgttttgtgt ggaaaatata tcattgatga aatcgctaaa
     3181 cgctttccta aacttgttag tagaagttta acacaattaa aaaactatct attactgtat
     3241 cgaaaagttg aacagctttt tttgaaggat gttcctaaat tgattcaaaa cagatttatt
     3301 tcaaaccaat gtgaaaattt taaaatggaa gatttacaaa ttactgtatc gggagatttt
     3361 cataatggtt caggcgtgtg tattttgttt tacaagggag agcgagttat ctataaagga
     3421 aaaaataatt tcgctaatca attgttgatt gaaatatttt ccaaacttgg agatgaattt
     3481 gaagagtcat tagagttttt accacgatat attgattgtg gtgattatta ttgggaagaa
     3541 tatatagagc atacttcgat aagaaactcg aacatatcag caagtgaata ctacaaaaga
     3601 tttgggtatt tattggcagt agcttattta ttgaatattt ctgatcttca ctttgaaaat
     3661 atattagcta gtggtgatat tccaaaatta gtagatgtag agactatttt caatttacaa
     3721 ccctatgaga ttctctcaga aacaattgcg gataaagatt tattaaagag aaatgcagaa
     3781 tcagtattgc tgacagggtt gttaccttta gctggttcta atgaagtatt cggtggagat
     3841 actagtggta tcctaggagg aaaatttgta ggagaagtta gagttatcca aaatcaaatg
     3901 agagatgaca tcagtgtgaa gaggcaagtt gttagaaaaa caaataagtc gcatcttcct
     3961 ttttatatct ctgagggcga agaacagtat tttgaggtca aagactatct tagggaactt
     4021 ttattcggtt ttaaaaaagt tacgagttat gttgaaaatc aaaaaaatac attcttatca
     4081 attatcgaaa aatattccga aaaaattgat gttcgtatat tatttaggaa tacaaaagat
     4141 tatagtattg tcagaacgct attactctct ccaaagtatt cagaaaacga taatataata
     4201 tttgagaaat ttaaaaataa acttgttaat tatcagtccg atgagttgtg tgaatcggaa
     4261 atcaaacaat tagaacaaat ggatatacca tacttcagta tgaaatcaaa ttcctgtgat
     4321 gtatatgatt tatatgggaa tgctgtatgg agtacatatt acagtccgat tgaactaata
     4381 agaaagaaaa tacaaaattt gagtgttcat ataattgagg agcagtataa acttattgaa
     4441 ttttctattt catcaactct taggctatac aatcaggaag ctttacctag aataaatgat
     4501 gtagaagata aaagttattc agatagtatt ttatataaag gtgtgcaaaa tatagttgat
     4561 cgtttgttgg gtgctattta tctttctaac agtgatcaga catgtaattg gttaactctt
     4621 tcaattaata atgtagattg tttggaatta agtccaatgg actgtacatt gtatggcgga
     4681 ctttctggag tggcattggc tttaatagaa tcaatgactc tattagaaga ggactatcgt
     4741 aaaaaagtca gaagcgttct accatatttg tataattcaa ttctaaaaaa atatgaatat
     4801 ttaactaatg attcttttta tatgggtagg atgggtgtgc tatatacact aaaaaaactt
     4861 tcgaaagagg ttgggaaaga tttagataat tgggtaaaca tagagattga taatgttatt
     4921 tcaaggttaa atatcgggga tactgatttt ttaactggta taagtagcgt gattcctgct
     4981 attaggttag aaaatttaaa taaggtaaca tttgaagaat tatcggatat ttacataaaa
     5041 caagcaaaag agaaagataa ttttgttttt tggggcaatg aacaatcaaa taatgtcagc
     5101 cttgcacatg ggaatttagg aattgaactt gctttagtta gacttataaa ggtgttggac
     5161 aactcaaaca ataaagagac tatttcaact cttcttaaaa aagctataaa ttttgacaat
     5221 cttcaaagga gagagcatgg ctgggtggat aatagaaatt tttctcatag cgcgaattgg
     5281 tgtcatggag caacaggagt gttactctct aggatagatt tatataatca acttaaaaat
     5341 gacaaaacag caactataag tagcactgat ttgcaacagg atgttattca ctctctacaa
     5401 gatattaaag aagtgggatt gaatcttgct aatttctccc tttgtcacgg agtaagtggg
     5461 aatctactaa ccttagtgca tacacagaac ttcttcgatg agaataatat tgtcaataac
     5521 tacaatttga aaaaatttgt tagagaaaat ttttataaaa tacatcttta tggtttgcaa
     5581 aatggttgga tgtgtaattt taatacaaag tatgattctt acgccctttt tactggaata
     5641 tcaggtattt tatatgctac cactctttac cttaaaaatg atataaaatc agatgtgtta
     5701 cttccgaata ttgtatctta agggagttta cttatgaaga tcatattgca aaataatgaa
     5761 tcagattgtt tgttggcatg ctatgctatg ttattaaata atctaggttt ggagatacca
     5821 ttgtatgaga tatacaagga agatatgata ccagcagatg gattaaatgt ttcctatttg
     5881 ataaagttga ataaacgttt caaagttggt atcaaggctt acagaatact gttgaaggat
     5941 attgctgttt gcttagaaaa aaacattcca gttattttac attggaatga taatcatttt
     6001 gttgtcttac tgaaaataag aaataaaaaa tatacaataa ttgatcctgc tataggtaag
     6061 attacttact cagaggaaga agttttaaaa cattattctg gtatttgcgt aacagttttt
     6121 aaaggagtag aatttaaaag aattaaatac tccaatctat ttgtggaaca attaaggcaa
     6181 actattagac tgaaaccagc aatgtatttt atattagcat tgggacttac acaagccgga
     6241 gtattcttgt tttccataac gattagaaat attctagatg tgaaatattc tttcattgct
     6301 tctttgttaa tgctcatgag tgtagtggtt gtacaattaa tttctgtctt aataaaaaac
     6361 gagactattt cagaatttaa taatgatttt gatgaaaatt atgtcaataa attattcaaa
     6421 atgttattaa ataaaccttt actatatttt agaaatatgt ccaatggagt attaggagaa
     6481 aaaattaatt taaaatcaac aataagggat agcatcacgt taaaacttct cccctctatt
     6541 gtaggattta tatcgttatt tgttgtgata ttatatctac taactatctc aactaaatta
     6601 acctttatac ttttaatctt attgattttt tatggtattg tttcatctgt attatataaa
     6661 aagcaaaacg aactgaatca tgcttattta caatatttga ttgattttaa ttctgtgctc
     6721 caaacagatt tagagaatat agattttatc aagattgcta gaaaggaaga acaaatcttt
     6781 aagtcatgga aatctagtaa taatttagtg acagataaat attctagtat tctaaaagta
     6841 gaaaattttt ctcaatttgt tggttctacc tttaattata tttctttatc cttaattctg
     6901 attttaggta tttattttaa agcttatttt gaagtatcaa taccagattt aatattatat
     6961 cagactagtg tatcgctgat gatatcgttt tttgagcaga ttaagcaatc tatatttgag
     7021 atagcgaaac tgcaagtcta tgcagaaaag cagagtgatt tgtttacaaa taatgctagt
     7081 atagagatac caatagataa cgagcaatct tctgtcatta gatgcgataa agtaaatttc
     7141 tcttataata accagaaact atatagtgga ataaatcttg aaatattaaa aggtgagaaa
     7201 attgctatat taggtgaatc gggttcaggt aagtccacat tgttgttact acttctagga
     7261 atgttaaggt atgatggaga gctaacgtat ggtgtcagtg atttcaccag tagaattggg
     7321 gttgtcttac aaaatatgac tttagtccct gatacaatct tgaaaaattt agattgtgct
     7381 cctagcgatg aggatttgga gagaatactt cgagatacag gtggtgaaag agttattgca
     7441 aaattgccta ataaactatt ttcaaaagtt ttgaagtcgg gcaagaactt atctggagga
     7501 caaattcaaa aattgctaat atcaagatca ctattaaata aacgagatat tattttttgg
     7561 gatgaagcct ttagtaacct agatgaaaaa agtaagaaaa aaatttatac agatgtttta
     7621 agtaatccat tttattcaga taaaacaatg gtaatagtga gtcaccaatt agatattgtg
     7681 aattatgttg attctatcat ttttgttgat aagagtagtg gggatgtaat caaggatact
     7741 catgataatt tgatttatag aaatcaaaat tatagaaaat tatttggttt aaaggagaaa
     7801 gttcataatg attagtaatg ttttacagat aaaaaactta caaaagggat ttaaggacac
     7861 tcaggtagtt aaccttagtt ccttatcagt tcaacaaggt gagatttatg gttttctagg
     7921 tccaaatgga gctgggaaaa caaccaccat gaagatgatt ttgtctttga tttctcgtac
     7981 agctggggag attgaagtgt tcggtcaatc tataggtacg gacaagcagt atcttaatca
     8041 gattggctct atgattgaag aaccgtctta ttatcctaat ttgacaggct atgaaaatct
     8101 cttggtcttc caaaaaatcc ttggatttga taagaaaaat attcaggaaa ccttgaaaat
     8161 tgtggggtta gatcaaccta aaaacaagaa aaaattggtt aaagattatt ctctgggtat
     8221 gaaacagcgt ttggctttag cctttgcctt agtcaagaaa ccacgtttgt tgatactgga
     8281 tgagccaaca aacgggctag acccagcagg gattcatgaa attcgagaac tgattatcaa
     8341 gttggcaaaa gaacagggca ttactgtctt catctctacc catatccttt ctgaagtaga
     8401 gcatatcgct gaccgtgtgg ggattatcaa tcatggtcaa ctggtttacg agggagaaat
     8461 tcgtaaaatt cagtccaata aatggctgga agtgcgtggg gattttagag atcgacgtga
     8521 agtcattagc caagtgttat ttggttatcc gtgcaagatg ttagagatac aagaggataa
     8581 actcaagctg actaaccttg ccgatcagca gatttctagt ttgttacgag atttaatagt
     8641 cgagaaagtt ccaatttatg aagtgaagca agaacaagaa accttggaat ctatcttcct
     8701 taacttaacc aaggagtgag tcttatgttg aataatttgt ctattgaatt gctcaaggca
     8761 aaacgaacca aatccttcct cattagcata ctagttatgg gagtcggatt tgcttgggca
     8821 attgtagccg ctacacgcta cctaagtaat ccaaacatac accagattag cctaattttc
     8881 tatatgataa aagaagtaaa tggcttgatt ctccctattg tgattgctct ctttgtatcg
     8941 cggattgtca agaacgagaa ggagggcaac actttcaaac tgcttttggc aaatggtgaa
     9001 aatgtacggc atatctttct gagtaagctt ggcctgacta tgttcgtttt ggcctttctc
     9061 gcttttttgg agggagtagt agtccagttg attgcaatct tatctggtct agaaatgcct
     9121 gttagcctaa tcctctggca aatcgtcatt ttcttgctag cctcttttgt cttgacctgt
     9181 ctgtttttga ctttgcagtt tttactgaaa aagcaggcat tgatactggc attagggatt
     9241 ttcggaggat ttcttggagt tggatttggt catgcaccag ctattctaca gctgattttc
     9301 ccttttggtg gtataggata tctgtctctg gtggattacc agcaagtcgc cagtcaagtg
     9361 agttatgttt tggtgacaaa cctaggattt aaactcttta catatttgcc aatagcccta
     9421 atctatctct tcttatctct ctatcttgtt gaaaagaaag gaggcaagct atgatgtctt
     9481 atctatcagt agaatggagg aaaaccaaaa aattttccat gttgatgatt ggtatttgct
     9541 tcttagcttt ttgtagcctg attggtcttg ggatttactt tggttcagct tattctattg
     9601 ttgcagaaag tgaaaaagtc cctgttttat ggggacaatt gaccttctat tatagccagc
     9661 ttttctttcc gattttggtc agcctttatg tagccatgat gttaggaaaa gagtttgata
     9721 gaaaaaatat tgaatttctc agagctaata atgtcagtct tgggaaatta ttattggcaa
     9781 aagaaatagt aattatcttg tttattgctg ttttacagtt gttcttgttt ggtatttttt
     9841 atgtcagtgc tcacctagct catttagaaa tttctaattt gttcacctac ctcaagtggg
     9901 atttattggg gatttttgga acaattagta tgatggcagt gcagttcttt gtgacagcta
     9961 aaactcgtgt tttcagtaaa tctgtgggaa ttggtgctat tggtactttc gtaggattta
    10021 tgatgatttt tgtatcagat aaattatctt taatctatcc ctactcccaa gctatggtgg
    10081 caatgcggtc acggaatttg atagacttta atttagtgga aatattgctg tttatcattg
    10141 taaatattct tctgtggggg atttttcata cattgagtaa taaagaattg cataagtaat
    10201 gcgaagactc ttcggagtct ttttcttgtg ataaaagctc caagctttat cggctctttt
    10261 ctaccatttg tcaagtctat cacggcttta agtaaaaaag agagaagaca gtagctattc
    10321 tgagattact gtcttatttt taacactttt tgatccataa aaaggtatgc taaaaaacac
    10381 ctcatctggt attttttgaa acaaggtgtt accctagtac ggcatagaca gccttatcta
    10441 ttttgggtca aagagtaatc gtaaagtttg ttaagcgtaa taaggtaata cattgtctga
    10501 atgagacgat gtattgaagg aactgcatga ggatttgttg aaggtattgt ctttttcgtt
    10561 tctcataaaa gtcagcgata tggcagcgat atggcaggga ttggtagact gaaagcaacg
    10621 catatctccc aattcgccaa tgatagatgt cgctgtggtt tctgcgatgc caggaattga
    10681 ccgtaagatg tcatactctg gtaaaggctg aactagagct accatgttgt ttaagacaac
    10741 ttgtctgcgt tcagaaagac gaagcaattc ttgagcatag taacggacct cttccatcat
    10801 gggagaggtt ttcttgattg cacaaaaaga ttgtttagag agctttataa gtttatcagt
    10861 caggtaagca atacgctttt cagagatatg tttggaggta gattgacgga taatttcaca
    10921 caagtcactt tgagataggc ttaatacaaa ttctttgcat ggaaaagcca tcattaagtt
    10981 ccaatattgc tctccagtag gtgtggataa tagattctcc aattcaggaa aagtgacttg
    11041 tagaaccttg tgcagacggt ttctagttcg aacaagatcc tctatcatat tttgatagaa
    11101 acatcttaaa tcacgcaggt gttgataaac ttcttcctgc acataagttg ctttacgatt
    11161 gtgcacaagc tgagatttag ctaacttttc agcgtcaatt ttatctgttt tacgaactcg
    11221 cagactgtcc aattgcttct tagcttccag aggacttagc cgtgtgtgag tcctcaagaa
    11281 aggcttgaag acgtcgataa tagacgcctg tagcctcaaa tataatctca gggttatgaa
    11341 cagttttcaa gtcgcccaac aggcgattga atccaatggt attattgagt atggtgtagc
    11401 catgaacctt ttcaccgttg actaaattgc cactcagaac ttgtcttact cacatcaatt
    11461 acaaaaattg cacgtatgac attatctctt ttggcttgaa taattccatg ttttattgat
    11521 tttattttca atacgcggcg tttagcgtcc tacatacttt gttcaaattc ctcctaaagc
    11581 aaggtatctt tcctgtttgt caagcgatgt ctagcgctat agtcccctaa gactatacaa
    11641 gacaccacta ctttaacata aagaaaaata gtgagtactc tcttccaccg gagatttctt
    11701 cactactaat cttagtatgt ttactatatg cttaatacga atttaatata agtttttctg
    11761 aagaagcact ttactgttat tagaaaatgc gggagatata attagtctta aataatagtc
    11821 atatagctat ttaattgcgg aatcctacta taccggtttt ttattgcgat aagcgattat
    11881 gagaaactgt ttgaattaat aggttcccta acaaaaaaac tgccaaaaat aaatttggca
    11941 gtttttttgt ttttctattt tagattggtt ttgtttatca tatcctctac catgagattg
    12001 aaatatgaac gctttttttg atttattgtc ttttcgcttg aaataattaa agcatatatg
    12061 aatagattgt ctcctatatc ataatttata tctgatactc gcattttttt actatattgg
    12121 agtttgactg tgaagtcaaa attgtcctta acaataagtt caatccaatt agaattattt
    12181 tttcgaatat atgaatgact tttccgtata cataacattt tgcatctgat ttgggatgtg
    12241 agaatcctaa tttcttttga ttatcaaaaa gtgctcagat agttcacttt gcgattcaga
    12301 aattgaatca attatgataa attgatcaat acctccaaaa ctattttgtt cattttcaat
    12361 atgtgctgta attatcacat atattcatat cgtgaatcaa tatattttat aacagtgagt
    12421 tttttattat tatttgagaa aatttgtaac ttggttccgt cgaactttat ttttcctttt
    12481 atgctaactt caactctatc taatcctaag aaagcggtcg tgttggaaaa acaatcatag
    12541 atatgttgct cattattaat gagatctttt tcgctatgtt tttttatcag ataaattgta
    12601 aaatatagtg caacaaaaaa actcatagcc tttcattggt gtaaactgta agtaaccaca
    12661 caaacagaac ccgaggaaaa actatgagct actcccatct taccataacc gaccgaataa
    12721 agatagaaac ctacttagaa ttaggttgga aaccttgcca aattgcaagt aaacttggcg
    12781 tccataagtc taccatttca agagaattaa gacgatgcca aaatggttat ttcgcagcct
    12841 tagcacagga acagtacgac cacagggcta aacaaaaagg tcggaagtct tgtttgacac
    12901 cagagttgaa aaaggaaatt gaggacggtt taaaatcctc ctggtcgcct gaacagattt
    12961 gtggccgcta tcagcttgaa caaaagccaa tggtagcttt taaaactatc tataactggc
    13021 tctatgctgg tttgattgat ctggatttaa gcgtccttcg tcgcaaagga aagactcgac
    13081 aacccaaaga aacacgtggg acatttagga ttggcacatc aattgccaaa cgtcctaaag
    13141 aggtcaggaa tcgtgagact tttggccact gggagcttga tactgtggtg tcttccagag
    13201 gcaaaagcaa gggctgttta gcgacctttc tggagcgaaa aacgcgcttt tacatagctt
    13261 tcaagatacc agacagaaca gccaaatcca tgttttcagc catcagacaa ctttgtaagc
    13321 tatttccaaa agaggctctt aaaaccttca cttcagacag gggaaaagag tttgcctgct
    13381 atcctctggt agagaactta ggaattccat ttttctttgc ggacgcctat tcatcctggt
    13441 agagaggagg caatgaaaac gcaaatggct tacttagaga atatttccca aagaaaacag
    13501 atttagccgc tatctctgag gaggctttga acaaagcctt atatgatatc aatcacagac
    13561 cgcgaaaatg tttagcttac agaactgctt gtgaagctct agaggatgag ttcgagtaaa
    13621 tgttgcactt attcttgcaa tttatcatca caaaagaata ttttcctttc gtttatgata
    13681 ttatgttgtt ttttacacat atttctttca attttgaaaa gcttaaagcg agaatgagag
    13741 tgacgcgtta actttttaag ttggtcagaa aaagtagtct agaataaaat aaaaaaagca
    13801 taatagaaaa taaaaggaat ttttcttgat tttgtgagct acaaataaaa ctatttttct
    13861 tctatataat aagtaagata aataataaaa taacagctgg atgaacaatt atttttgatg
    13921 cccaattatc catgtgagtt tgaagtgaca tttttagatg attaccataa aaaacacaac
    13981 tacccactat tttatgaatc ctatcttcaa aacattatgg aattccttga aagtcaggat
    14041 ataaagaacg gagctgatgc ctttgtagat gatcatcaaa atcttgtttt tgttttatat
    14101 ggacaaggct atcgagccga gggaaaagag ggaatactta caacccaagt aactgtaaaa
    14161 gcttatgatg aagacaataa accgattaac ctcgcaaatt tattagattc cttaatcgtc
    14221 tcagaatatc aaatggaagc gaatctttgg gaggtctctc atgattgatc tctatctaag
    14281 taaaaatagc caaagaaatc aacttctttt ggatttcttt caaaagtatg gcatagaggt
    14341 cactcctcat tctatttctg aaatgacaaa ggacaaatta attgaaatga tgagctattc
    14401 ttcagattgt tttgagtatt tatctcccaa tttattacga tttaagaacc gtgacaatct
    14461 aagattaacg gatttcgttg agatgttttt aaaaaatcct gaactaacca tcagacttcc
    14521 tcttgcggtt tcaaataagc gagtttatcc aaatctgaat ttggaagagg ctagagctct
    14581 attgccaaga gatacgaaac aattgattta catagcacaa acacattatt tatctagcta
    14641 aaggagaagc aatatggctg aacgattttg ggagaacttg tccattattt tggctgaaag
    14701 aaatatcagc tggattgagt taaccagaaa aatgtttgcg ggagagtttc actatccaag
    14761 tgaattgaat cgtttgtatc aaaagattgt gagtctccat gcacaaagtt cgaccaaagc
    14821 agatgccatg aagaaactac gaacaaagaa gaccttgatg gaatcccaaa agatcgggga
    14881 acaacaaaaa ctagctcgta caggtatcta tttggaaaaa gtaggtcatg tattagaaag
    14941 caatatcgat gaggctgagg agctattaaa aaccatgaca gagacaggag ataaactgtt
    15001 tcaaacagtc ttcttgattg gtgtctttgg tcaggatgaa gaagaactca aacaagctct
    15061 agacactatc caacaagtgg ccggctcaaa tgacctaatg attgataaag aagtcaaggc
    15121 cgcaaaagag aatctaagaa attgcagtcc atttatgatg cgatttccga attatactaa
    15181 gcagtcctga taggctgatt ttttgagaga ttatagatgt ttacaacatt ttttaagaaa
    15241 aaccaagaca gtggtgatat atttaagaag ctaattcacc gactatctga tatgtccgtc
    15301 ccagatcttg aaaaaataga cctactgata gatatcattt tcactccaaa tcaagaaacc
    15361 gaacaacttt aaagagaatc aacttataga gaagaaactt tggacgatac attaaaagaa
    15421 gctaagaatc aacttcataa ggaacaatta gagaagaatt tagagagatt taggaaaaat
    15481 agtcaataac gcaccaaaaa tggtgcattt gctttttcta aatgttataa tggtggtatc
    15541 aaataaaagg agtttgctat gattggaaaa aacataaaat ccttacgtaa aacacatggc
    15601 ttaacacaac ccgaatttgc ccgaattata ggaatttctc gaaatagctt aagccgttat
    15661 gaaaatggaa ctagttcagt atctacagaa ctaatagaca tcatttgtca gaagtttaat
    15721 g
//
